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https://www.readbyqxmd.com/read/28822204/comparative-2-d-electrophoresis-of-salivary-proteins-in-triatoma-dimidiata-and-rhodnius-prolixus-hemiptera-reduviidae-and-major-cross-reactive-antigens
#1
Victor Monteon, Ivan May-Gil, Karla Acosta-Viana, Angel Ramos-Logonio, Oscar Hernandez, Ruth Lopez
An immune response to triatomine’s saliva is an immunological marker of exposure to triatomine bites. However, considerable variability in salivary protein profiles did exist among species. In the present work, we compare salivary proteins from Mexican Triatoma dimidiata and Rhodnius prolixus using 2-D electrophoresis. A clear differential saliva profile was found to exist between these two triatomine species. Fewer protein spots were detected in R. prolixus than in T. dimidiata. More than half of the proteins had an isoelectric point between 5 and 7 and a molecular weight between 10 and 30 kDa in T...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28821531/cd28-and-41bb-costimulation-enhances-the-effector-function-of-cd19-specific-engager-t-cells
#2
Mireya Paulina Velasquez, Arpad Szoor, Abishek Vaidya, Aarohi Thakkar, Phuong Nguyen, Meng-Fen Wu, Hao Liu, Stephen Gottschalk
T cells expressing CD19-specific chimeric antigen receptors (CARs) with endodomains that encode a signaling domain derived from CD3zeta and CD28 or 41BB have potent antitumor activity in early phase clinical studies for B-cell malignancies. Besides CD19-specific CARs, other approaches are actively being pursued to redirect T cells to CD19, including recombinant bispecific T-cell engager (BiTE) proteins or T cells genetically modified to express BiTEs (engager [ENG] T cells). Since BiTEs provide no costimulation, we investigated here if provision of costimulation through CD28 and 41BB enhances the effector function of CD19-ENG T cells...
August 18, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28821272/novel-immunotherapies-for-adult-patients-with-b-lineage-acute-lymphoblastic-leukemia
#3
REVIEW
Guoqing Wei, Jiasheng Wang, He Huang, Yanmin Zhao
The past decade witnessed the rapid development of adult B-lineage acute lymphoblastic leukemia (ALL) treatment. Beyond the development of chemotherapy regimens, immunotherapy is starting a new era with unprecedented complete remission (CR) rate. Targeting B-lineage-specific surface markers such as CD19, CD20, CD22, or CD52, immunotherapy has been demonstrating promising clinical results. Among the immunotherapeutic methods, naked monoclonal antibodies (mAbs), antibody-drug conjugate (ADC), bispecific T cell engager (BiTE), and chimeric antigen receptor (CAR) T cells are the main types...
August 18, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28819502/pattern-and-outcome-of-dog-bite-injuries-among-children-in-ado-ekiti-southwest-nigeria
#4
Ezra Olatunde Ogundare, Oladele Simeon Olatunya, Isaac Oluwadare Oluwayemi, Adekoya Joshua Inubile, Adekunle Bamidele Taiwo, Oyinkansola Tolulope Agaja, Alfred Airemionkhale, Adewale Fabunmi
INTRODUCTION: Dog bites in humans are a major public health problem. Globally, millions of people are bitten by dogs but most of the fatal cases occur in children. There is paucity of data on dog bite related diseases among Nigerian children. Objectives: to determine the pattern of dog bite injuries and associated health problems among children seen at Ekiti State University Teaching Hospital. METHODS: This is a retrospective study on the clinical data of patients managed for dog bite related injuries between January 2010 and June 2014...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28817066/consistency-of-eating-rate-oral-processing-behaviours-and-energy-intake-across-meals
#5
Keri McCrickerd, Ciaran G Forde
Faster eating has been identified as a risk factor for obesity and the current study tested whether eating rate is consistent within an individual and linked to energy intake across multiple meals. Measures of ad libitum intake, eating rate, and oral processing at the same or similar test meal were recorded on four non-consecutive days for 146 participants (117 male, 29 female) recruited across four separate studies. All the meals were video recorded, and oral processing behaviours were derived through behavioural coding...
August 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28815684/cognitive-psychophysiological-treatment-of-bodily-focused-repetitive-behaviors-in-adults-an-open-trial
#6
Kieron O'Connor, Marc Lavoie, Benoît Desaulniers, Jean-Sébastien Audet
BACKGROUND: Body-focused repetitive behaviors (BFRBs), such as hair pulling, skin picking, and nail biting, are repetitive, destructive, and nonfunctional habits that cause significant distress. Separate BFRBs form a cohesive group and could be assessed as part of the Tourette/tic spectrum or obsessive-compulsive spectrum of disorders. The treatment of choice is either antidepressant or behavioral treatment, both of which have shown effectiveness. The cognitive psychophysiological (CoPs) model focuses on the tension and emotional build up that triggers habits by addressing cognitive-behavioral, emotional and psychophysiological processes preceding onset rather than the habit itself...
August 16, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28815016/erratum-to-dog-bite-injuries-to-humans-and-the-use-of-breed-specific-legislation-a-comparison-of-bites-from-legislated-and-non-legislated-dog-breeds
#7
Nanci Creedon, Páraic S Ó Súilleabháin
[This corrects the article DOI: 10.1186/s13620-017-0101-1.].
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28815000/african-tick-bite-fever-in-returning-swedish-travellers-report-of-two-cases-and-aspects-of-diagnostics
#8
Kenneth Nilsson, Katarina Wallménius, Pernilla Rundlöf-Nygren, Susanne Strömdahl, Carl Påhlson
Introduction: African tick-bite fever, caused by Rickettsia africae, is endemic in rural areas of sub-Saharan Africa and a possible cause of fever in returning Swedish travellers. Two patients are presented, and the advantages and disadvantages of different diagnostic methods are discussed. Patients and methods: Two middle-aged men fell ill with fever after returning home from South Africa. Both had single eschars and one also presented with a lymph node swelling. Samples were taken for serology, general bacterial culture from the wound (Patient 1) using a swab and additionally for Patient 2 PCR of a skin biopsy from the eschar...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/28813570/experimental-and-numerical-characterization-of-the-mechanical-masseter-muscle-response-during-mastication
#9
Johannes Weickenmeier, Mahmood Jabareen, Benjamin J D Le Révérend, Marco Ramaioli, Edoardo Mazza
Predictive simulations of the mastication system would significantly improve our understanding of temporomandibular joint disorders and the planning of cranio-maxillofacial surgery procedures. Respective computational models must be validated by experimental data from in-vivo characterization of the mastication system's mechanical response. The present work introduces a combined experimental and numerical procedure for the validation of a computer model of the masseter muscle during biting. The proposed experimental setup enables simultaneous bite force measurements and ultrasound-based visualization of masseter deformation for the direct comparison with the numerically predicted masseter response...
August 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28813431/skeleton-of-an-unusual-cat-sized-marsupial-relative-metatheria-marsupialiformes-from-the-middle-eocene-lutetian-44-43-million-years-ago-of-turkey
#10
A Murat Maga, Robin M D Beck
We describe a near-complete, three-dimensionally preserved skeleton of a metatherian (relative of modern marsupials) from the middle Eocene (Lutetian: 44-43 million years ago) Lülük member of the Uzunçarşıdere Formation, central Turkey. With an estimated body mass of 3-4 kg, about the size of a domestic cat (Felis catus) or spotted quoll (Dasyurus maculatus), it is an order of magnitude larger than the largest fossil metatherians previously known from the Cenozoic of the northern hemisphere. This new taxon is characterised by large, broad third premolars that probably represent adaptations for hard object feeding (durophagy), and its craniodental morphology suggests the capacity to generate high bite forces...
2017: PloS One
https://www.readbyqxmd.com/read/28811962/an-ror1-bi-specific-t-cell-engager-provides-effective-targeting-and-cytotoxicity-against-a-range-of-solid-tumors
#11
Satyen Harish Gohil, Solange Rosa Paredes-Moscosso, Micaela Harrasser, Marzia Vezzalini, Aldo Scarpa, Emma Morris, Andrew M Davidoff, Claudio Sorio, Amit Chunilal Nathwani, Marco Della Peruta
We have developed a humanized bi-specific T-cell engager (BiTE) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a cell surface antigen present on a range of malignancies and cancer-initiating cells. Focusing initially on pancreatic cancer, we demonstrated that our ROR1 BiTE results in T cell mediated and antigen-specific cytotoxicity against ROR1-expressing pancreatic cancer cell lines in vitro at exceedingly low concentrations (0.1 ng/mL) and low effector to target ratios. Our BiTE prevented engraftment of pancreatic tumor xenografts in murine models and reduced the size of established subcutaneous tumors by at least 3-fold...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811247/pharmacological-analysis-of-poecilotheria-spider-venoms-in-mice-provides-clues-for-human-treatment
#12
Alexander Andreev-Andrievskiy, Anfisa Popova, Evgeniia Lagereva, Daniil Osipov, Antonina Berkut, Eugene Grishin, Alexander Vassilevski
Bites of tiger spiders belonging to Poecilotheria genus cause moderate to severe pain and long-lasting local or generalized muscle cramps in humans. Bites occur in regions of the spiders' natural habitat, India and Sri Lanka, but the popularity of these colorful tarantulas as pets leads to reports of envenomation cases worldwide. Treatment is predominantly symptomatic and often inadequate since there is almost no clinical or toxicology research data available, and physicians outside India or Sri Lanka typically have no experience in treating such cases...
August 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28810997/cutaneous-leishmaniasis-in-a-saudi-arabian-soldier-stationed-in-the-united-states
#13
Kelly Laurent, Jason Susong, Eric Fillman, Simon Ritchie
BACKGROUND: Leishmaniasis is a common parasitic disease seen in many parts of the world, especially in areas where current U.S. and international forces are deployed. Approximately 350 million people are thought to be at risk of cutaneous leishmaniasis (CL) with an annual incidence of 1.5 million cases. Over 90% of cutaneous infections with Leishmania occur in the Middle East, Brazil, and Peru. Outbreaks of CL may occur in military personnel deployed to endemic areas. Since the incubation period for symptomatic CL ranges from weeks to months, symptoms may not appear until well after returning to the United States...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810679/association-of-endotoxin-and-allergens-with-respiratory-and-skin-symptoms-a-descriptive-study-in-laboratory-animal-workers
#14
Anne Oppliger, Fabio Barresi, Marion Maggi, Peter Schmid-Grendelmeier, Francois Huaux, Philipp Hotz, Holger Dressel
Background: In laboratory animal work, allergens are classically considered to play a prominent role in generation of respiratory and skin symptoms. However, recent development may have changed working conditions and require an updating of preventive measures. Objective: In workers exposed to a range of animals besides laboratory mice and rats the relative role of endotoxin, irritants, and allergens in symptom generation was assessed for updating preventative measures and health surveillance...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28810671/beyond-the-p-value-and-the-sound-bite-learning-from-negative-clinical-trials
#15
Akshay S Desai, Marc A Pfeffer
No abstract text is available yet for this article.
August 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28807935/function-of-the-hypobranchial-muscles-and-hyoidiomandibular-ligament-during-suction-capture-and-bite-processing-in-white-spotted-bamboo-sharks-chiloscyllium-plagiosum
#16
Jason B Ramsay, Cheryl D Wilga
Suction feeding in teleost fish is a power dependant behavior, requiring rapid and forceful expansion of the orobranchial cavity by the hypobranchial and trunk muscles. To increase power production for expansion, many species employ in-series tendons and catch mechanisms to store and release elastic strain energy. Suction feeding sharks such as Chiloscyllium plagiosum lack large in-series tendons on the hypobranchials, yet two of the hypobranchials, the coracohyoideus and coracoarcualis (CH, CA; hyoid depressors), are arranged in-series, and run deep and parallel to a third muscle, the coracomandibularis (CM, jaw depressor)...
August 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28806618/public-sentiment-and-discourse-about-zika-virus-on-instagram
#17
E K Seltzer, E Horst-Martz, M Lu, R M Merchant
OBJECTIVE: Social media have strongly influenced the awareness and perceptions of public health emergencies, and a considerable amount of social media content is now shared through images, rather than text alone. This content can impact preparedness and response due to the popularity and real-time nature of social media platforms. We sought to explore how the image-sharing platform Instagram is used for information dissemination and conversation during the current Zika outbreak. STUDY DESIGN: This was a retrospective review of publicly posted images about Zika on Instagram...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28806430/a-randomized-controlled-trial-of-mastication-with-complete-dentures-made-by-a-conventional-or-an-abbreviated-technique
#18
Cristiane Machado Mengatto, Gustavo Hauber Gameiro, Mario Brondani, C Peter Owen, Michael I MacEntee
PURPOSE: The aim of this randomized clinical trial was to test the hypothesis that there are no statistically significant differences after 3 and 6 months in masticatory performance or chewing ability of people with new complete dentures made by an abbreviated or a conventional technique. MATERIALS AND METHODS: The trial included 20 edentulous participants at a dental school in Brazil assigned randomly to receive dentures made by either a conventional technique involving six clinical sessions or by an abbreviated technique involving three clinical sessions...
August 14, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28805302/torix-group-rickettsia-are-widespread-in-culicoides-biting-midges-diptera-ceratopogonidae-reach-high-frequency-and-carry-unique-genomic-features
#19
Jack Pilgrim, Mats Ander, Claire Garros, Matthew Baylis, Gregory D D Hurst, Stefanos Siozios
There is increasing interest in the heritable bacteria of invertebrate vectors of disease as they present novel targets for control initiatives. Previous studies on biting midges (Culicoides spp.), known to transmit several RNA viruses of veterinary importance, have revealed infections with the endosymbiotic bacteria, Wolbachia and Cardinium. However, rickettsial symbionts in these vectors are underexplored. Here, we present the genome of a previously uncharacterized Rickettsia endosymbiont from Culicoides newsteadi (RiCNE)...
August 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28799315/glucose-6-phosphate-dehydrogenase-deficiency-unveiled-by-diabetic-ketoacidosis-a-dual-dilemma
#20
Pankti Mehta, Vishal Srivastav, Priya Bhate, Vishal Gupta, Milind Y Nadkar
An 18 year old male, known case of Type 1 Diabetes Mellitus was admitted in view of diabetic ketoacidosis. With normalization of blood sugars patient developed gross reddish discoloration of urine. Urine routine microscopy did not reveal RBCs or RBC casts. Peripheral blood smear revealed bite cells, Heinz bodies and spherocytes. Thus a diagnosis of hemolytic anemia with hemoglobinuria was made. Patient's glucose-6-phosphate dehydrogenase (G6PD) levels were below the normal range. G6PD, an enzyme of the HMP shunt, is the most common enzyme defect causing hemolytic anemia...
August 2017: Journal of the Association of Physicians of India
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