Damian Di Florio, David Gorelov, Elizabeth McCabe, Danielle Beetler, Katie Shapiro, Katelyn Bruno, Isha Chekuri, Angita Jain, Emily Whelan, Gary Salomon, Sami Khatib, Natalie Bonvie-Hill, Presley Giresi, Varsini Balamurugan, Gabriel Weigel, Jessica Fliess, Ashley Darakjian, Brandy Edenfield, Christian Kocsis, Christopher McLeod, Leslie Cooper, Etienne Audet-Walsh, Michael Coronado, Jon Sin, DeLisa Fairweather
Background Myocarditis is an inflammation of the heart muscle most often caused by an immune response to viral infections. Sex differences in the immune response during myocarditis have been well described but upstream mechanisms in the heart that might influence sex differences in disease are not completely understood. Methods Male and female BALB/c wild type mice received an intraperitoneal injection of heart-passaged coxsackievirus B3 (CVB3) or vehicle control. Bulk-tissue RNA-sequencing was conducted to better understand sex differences in CVB3 myocarditis...
December 19, 2023: Research Square