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Coxsackie b

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https://www.readbyqxmd.com/read/28068282/serological-and-molecular-biological-studies-of-parvovirus-b19-coxsackie-b-viruses-and-adenoviruses-as-potential-cardiotropic-viruses-in-bulgaria
#1
Stefka Kr Ivanova, Svetla G Angelova, Asya P Stoyanova, Irina L Georgieva, Lubomira K Nikolaeva-Glomb, Zafira G Mihneva, Neli St Korsun
BACKGROUND: Inflammatory diseases of the heart (myocarditis, pericarditis) are commonly caused by viruses. Among the human cardiotropic viruses, parvovirus B19, Coxsackie B viruses, and adenoviruses play a leading role. AIM: The aim of the present study was to determine the presumptive causative role of parvovirus B19, Coxsackie B viruses, and adenoviruses in the development of myocarditis, pericarditis and dilated cardiomyopathy by demonstrating the presence of specific antiviral antibodies or viral DNA in patients' serum samples...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28039136/laboratory-surveillance-of-polio-and-other-enteroviruses-in-high-risk-populations-and-environmental-samples
#2
Vasiliki Pogka, Stavroula Labropoulou, Mary Emmanouil, Androniki Voulgari-Kokota, Alexandra Vernardaki, Theano Georgakopoulou, Andreas F Mentis
: In the context of poliomyelitis eradication, a reinforced supplementary laboratory surveillance of enteroviruses was implemented in Greece. From 2008 to 2014, the Hellenic Polioviruses/Enteroviruses Reference Laboratory performed detailed supplementary surveillance of circulating enteroviruses among healthy individuals in high-risk population groups, among immigrants from poliovirus endemic countries as well as in environmental samples. In total, 722 stool samples and 179 sewage water samples were included in the study...
December 30, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27987278/clozapine-associated-cardiac-dysfunction-during-a-gastroenteritis-outbreak
#3
Anthony M Szema, Charles Marboe, Paul Fritz, Tram N B Nguyen
We report that two young adult patients who were initiated with clozapine for severe psychosis during a hospital-wide gastroenteritis outbreak went into severe shock. Neither patient had troponin elevation. Each required left ventricular assist device support for myocarditis. Endomyocardial biopsy revealed lymphocytic myocarditis in one patient and eosinophilic myocarditis in the other. The former patient expired. Polymerase chain reaction testing was negative for Coxsackie virus. These two patients illustrate that myocarditis can occur at usual incipient doses and that there may be an epidemiologic risk associated with gastroenteritis...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27933184/coxsackie-adenovirus-receptor-expression-is-enhanced-in-pancreas-from-patients-with-type-1-diabetes
#4
M Hodik, M Anagandula, J Fuxe, L Krogvold, K Dahl-Jørgensen, H Hyöty, L Sarmiento, G Frisk
OBJECTIVES: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what conditions that would change the expression. DESIGN: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27773751/soluble-coxsackie-and-adenovirus-receptor-scar-fc-a-highly-efficient-compound-against-laboratory-and-clinical-strains-of-coxsackie-b-virus
#5
Sandra Pinkert, Babette Dieringer, Sabine Diedrich, Heinz Zeichhardt, Jens Kurreck, Henry Fechner
Coxsackie-B-viruses (CVB) cause a wide variety of diseases, ranging from mild syndromes to life-threatening conditions such as pancreatitis, myocarditis, meningitis and encephalitis. Especially newborns and young infants develop severe diseases and long-term sequelae may occur among survivors. Due to lack of specific antiviral therapy the current treatment of CVB infection is limited to symptomatic treatment. Here we analyzed the antiviral activity of a soluble receptor fusion protein, containing the extracellular part of the coxsackievirus and adenovirus receptor (CAR) fused to the constant domain of the human IgG - sCAR-Fc - against laboratory and clinical CVB strains...
October 20, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27725476/clinical-features-of-acute-and-fulminant-myocarditis-in-children%C3%A3-2nd-nationwide-survey-by-japanese-society-of-pediatric-cardiology-and-cardiac-surgery
#6
Hiroyuki Matsuura, Fukiko Ichida, Tsutomu Saji, Shunichi Ogawa, Kenji Waki, Masahide Kaneko, Masahiro Tahara, Takashi Soga, Yasuo Ono, Satoshi Yasukochi
BACKGROUND: The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery of acute or fulminant myocarditis (AMC/FMC) in children revealed that the survival rate of FMC was only 51.6%. The 2nd nationwide survey was performed to evaluate the recent outcomes of pediatric myocarditis.Methods and Results:Questionnaires regarding patients aged ≤18 years with AMC/FMC during the period from January 2006 to December 2011 were mailed. A total of 221 cases (age 6...
October 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27617209/coxsackie-b5-infection-in-an-adult-with-fever-truncal-rash-diarrhea-and-splenomegaly-with-highly-elevated-ferritin-levels
#7
Paul K Valestra, Scarlet Herrarte Fornos, John Gian, Burke A Cunha
Coxsackie viruses are enteroviruses most common in children. Coxsackie B viral infections often present with biphasic fever, headache, pharyngitis, nausea/vomiting, diarrhea and a maculopapular rash that spares the palms and soles. These clinical features may be present in other viral infections. We present a case of a hospitalized adult with rash and fever with highly elevated ferritin levels later found to be due to Coxsackie B5. We believe this is the first case of Coxsackie B infection with otherwise unexplained highly elevated ferritin levels...
2016: IDCases
https://www.readbyqxmd.com/read/27604323/incomplete-immune-response-to-coxsackie-b-viruses-associates-with-early-autoimmunity-against-insulin
#8
Michelle P Ashton, Anne Eugster, Denise Walther, Natalie Daehling, Stephanie Riethausen, Denise Kuehn, Karin Klingel, Andreas Beyerlein, Stephanie Zillmer, Anette-Gabriele Ziegler, Ezio Bonifacio
Viral infections are associated with autoimmunity in type 1 diabetes. Here, we asked whether this association could be explained by variations in host immune response to a putative type 1 etiological factor, namely coxsackie B viruses (CVB). Heterogeneous antibody responses were observed against CVB capsid proteins. Heterogeneity was largely defined by different binding to VP1 or VP2. Antibody responses that were anti-VP2 competent but anti-VP1 deficient were unable to neutralize CVB, and were characteristic of children who developed early insulin-targeting autoimmunity, suggesting an impaired ability to clear CVB in early childhood...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27580327/absence-of-poliovirus-in-apparently-healthy-school-children-in-bauchi-state-nigeria
#9
Idris Abdullahi Nasir, Muhammad Sagir Shehu, Yunusa Thairu
INTRODUCTION: Poliovirus infections have been established to be in circulation in the remaining three polio-endemic nations. These pathogens have been associated with several chronic diseases, particularly acute flaccid paralysis of children. This study sought to ascertain whether polioviruses are silently shed by apparently healthy schoolchildren in Bauchi, Katagum, and Misau local government areas of Bauchi state, Nigeria. METHODOLOGY: This was a cross-sectional prospective study that involved 200 stool samples collected from apparently healthy schoolchildren...
August 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27507316/50-years-ago-in-thejournal-ofpediatrics-an-outbreak-of-coxsackie-b-5-virus-infection-in-a-newborn-nursery
#10
Sarah S Long
No abstract text is available yet for this article.
August 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27503532/effusive-constrictive-pericarditis-hepatitis-and-pancreatitis-in-a-patient-with-possible-coxsackievirus-b-infection-a-case-report
#11
Jon Persichino, Roger Garrison, Rajagopal Krishnan, Made Sutjita
BACKGROUND: Coxsackie B is a viral pathogen that presents with various invasive diseases in adults. Historically, the majority of adult cases with pericarditis or myocarditis have been attributed to coxsackievirus B. The presentation of this viral infection causing effusive-constrictive pericarditis, hepatitis or pancreatitis is rare. This case report is the first to describe a patient with concomitant effusive-constrictive pericarditis, hepatitis and pancreatitis from possible coxsackievirus B infection...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27501319/soluble-vascular-cell-adhesion-molecule-1-vcam-1-as-a-biomarker-in-the-mouse-model-of-experimental-autoimmune-myocarditis-eam
#12
U Grabmaier, G Kania, J Kreiner, J Grabmeier, A Uhl, B C Huber, K Lackermair, N Herbach, A Todica, U Eriksson, L T Weckbach, S Brunner
Vascular cell adhesion molecule-1 (VCAM-1) is strongly upregulated in hearts of mice with coxsackie virus-induced as well as in patients with viral infection-triggered dilated cardiomyopathy. Nevertheless, the role of its soluble form as a biomarker in inflammatory heart diseases remains unclear. Therefore, we investigated whether plasma levels of soluble VCAM-1 (sVCAM-1) directly correlated with disease activity and progression of cardiac dysfunction in the mouse model of experimental autoimmune myocarditis (EAM)...
2016: PloS One
https://www.readbyqxmd.com/read/27486657/increased-echogenicity-and-radiodense-foci-on-echocardiogram-and-microct-in-murine-myocarditis
#13
Angela K Peter, William H Bradford, Nancy D Dalton, Yusu Gu, Chieh-Ju Chao, Kirk L Peterson, Kirk U Knowlton
OBJECTIVES: To address the question as to whether echocardiographic and/or microcomputed tomography (microCT) analysis can be utilized to assess the extent of Coxsackie B virus (CVB) induced myocarditis in the absence of left ventricular dysfunction in the mouse. BACKGROUND: Viral myocarditis is a significant clinical problem with associated inflammation of the myocardium and myocardial injury. Murine models of myocarditis are commonly used to study the pathophysiology of the disease, but methods for imaging the mouse myocardium have been limited to echocardiographic assessment of ventricular dysfunction and, to a lesser extent, MRI imaging...
2016: PloS One
https://www.readbyqxmd.com/read/27367546/predominance-of-enterovirus-b-and-echovirus-30-as-cause-of-viral-meningitis-in-a-uk-population
#14
Christopher W Holmes, Sharon S F Koo, Husam Osman, Steven Wilson, Jacqueline Xerry, Chris I Gallimore, David J Allen, Julian W Tang
BACKGROUND/OBJECTIVES: Enteroviruses are the most common cause of aseptic or lymphocytic meningitis, particularly in children. With reports of unusually severe neurological disease in some patients infected with enterovirus D68 in North America, and a recent increase in the number of paediatric enterovirus meningitis cases presenting in this UK Midlands population, a retrospective regional surveillance study was performed. STUDY DESIGN: Cerebrospinal fluid (CSF) samples received were tested using the polymerase chain reaction (PCR) for HSV-1/2, VZV, enteroviruses and parechoviruses...
August 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27289561/domain-i-of-the-5-non-translated-genomic-region-in-coxsackievirus-b3-rna-is-not-required-for-productive-replication
#15
L Jaramillo, S Smithee, S Tracy, N M Chapman
Domain I is a cloverleaf-like secondary structure at the 5' termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5' genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality.
September 2016: Virology
https://www.readbyqxmd.com/read/27246444/enteroviruses-and-rhinoviruses-molecular-epidemiology-of-the-most-influenza-like-illness-associated-viruses-in-senegal
#16
Amary Fall, Ndongo Dia, Ousmane Kébé, Fatoumata Diene Sarr, Davy E Kiori, El Hadj Abdoul Khadir Cissé, Sara Sy, Deborah Goudiaby, Vincent Richard, Ousmane Madiagne Diop, Mbayame Ndiaye Niang
Different viruses have been identified as etiologic agents of respiratory tract infections, including severe cases. Among these, human rhinoviruses (HRVs) and human enteroviruses (HEVs) are recognized as leading causes. The present study describes the molecular epidemiology of HRVs and HEVs in Senegal over a 3-year surveillance period. From January 2012 to December 2014, nasopharyngeal and oropharyngeal swabs specimen were collected from patients with influenza-like illness (ILI). A real-time reverse transcription polymerase chain reaction was performed for HRV and HEV detection using the RV16 kit...
August 3, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27203670/efficacy-of-cd46-targeting-chimeric-ad5-35-adenoviral-gene-therapy-for-colorectal-cancers
#17
Young-Suk Cho, Manh-Hung Do, Se-Young Kwon, Changjong Moon, Kwonseop Kim, Keesook Lee, Sang-Jin Lee, Silvio Hemmi, Young-Eun Joo, Min Soo Kim, Chaeyong Jung
CD46 is a complement inhibitor membrane cofactor which also acts as a receptor for various microbes, including species B adenoviruses (Ads). While most Ad gene therapy vectors are derived from species C and infect cells through coxsackie-adenovirus receptor (CAR), CAR expression is downregulated in many cancer cells, resulting inefficient Ad-based therapeutics. Despite a limited knowledge on the expression status of many cancer cells, an increasing number of cancer gene therapy studies include fiber-modified Ad vectors redirected to the more ubiquitously expressed CD46...
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27109973/multiple-organ-failure-associated-with-coxsackie-virus-in-a-kidney-transplant-patient-case-report
#18
R Pretagostini, L Quirino, L Pettorini, M Garofalo, L Poli, F Melandro, G M Montalto, P B Berloco
INTRODUCTION: Viral myocarditis can emerge with various symptoms, including fatal arrhythmia and cardiogenic shock, potentially evolving in chronic myocarditis or dilatative cardiomyopathy. We report a case of a kidney transplant patient affected by coxsackie viral myocarditis. METHODS: A 49-year-old man was admitted to our hospital with dyspnea and fever in August 2014. He underwent living donor kidney transplantation in 1986 and polar graft resection for papillary carcinoma in 2012...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27030267/the-coxsackievirus-and-adenovirus-receptor-glycosylation-and-the-extracellular-d2-domain-are-not-required-for-coxsackievirus-b3-infection
#19
Sandra Pinkert, Carsten Röger, Jens Kurreck, Jeffrey M Bergelson, Henry Fechner
UNLABELLED: The coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin superfamily (IgSF) and functions as a receptor for coxsackie B viruses (CVBs). The extracellular portion of CAR comprises two glycosylated immunoglobulin-like domains, D1 and D2. CAR-D1 binds to the virus and is essential for virus infection; however, it is not known whether D2 is also important for infection, and the role of glycosylation has not been explored. To understand the function of these structural components in CAR-mediated CVB3 infection, we generated a panel of human (h) CAR deletion and substitution mutants and analyzed their functionality as CVB receptors, examining both virus binding and replication...
June 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27021682/halofuginone-alleviates-acute-viral-myocarditis-in-suckling-balb-c-mice-by-inhibiting-tgf-%C3%AE-1
#20
Xiao-Hua Sun, Jia Fu, Da-Qing Sun
Viral myocarditis (VMC) is an inflammation of heart muscle in infants and young adolescents. This study explored the function of halofuginone (HF) in Coxsackievirus B3 (CVB3) -treated suckling mice. HF-treated animal exhibited higher survival rate, lower heart/body weight, and more decreased blood sugar concentration than CVB3 group. HF also reduced the expressions of interleukin(IL)-17 and IL-23 and the numbers of Th17 cells. Moreover, HF downregulated pro-inflammatory cytokine levels and increased anti-inflammatory cytokine levels...
April 29, 2016: Biochemical and Biophysical Research Communications
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