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https://www.readbyqxmd.com/read/28638457/upregulation-of-coxsackie-adenovirus-receptor-sensitizes-cisplatin-resistant-lung-cancer-cells-to-crad-induced-inhibition
#1
Ali Sakhawat, Yanan Liu, Ling Ma, Tahir Muhammad, Shensen Wang, Lina Zhang, Xianling Cong, Yinghui Huang
Objective. Conditionally replicating adenoviruses (CRAds) have been proven potent oncolytic viruses in previous studies. They selectively replicate in the tumor cells because of incorporated survivin promoter and ultimately lead to their killing with minimal side effects on normal tissue. Chemotherapy with cisplatin is commonly employed for treating tumors, but its cytotoxic effects and development of resistance remained major concerns to be dealt with. The aim of this study was to explore the anticancer potential of survivin regulated CRAd alone or in combination with cisplatin in the A549 lung cancer cell line and cisplatin-resistant lung cancer cell line, A549-DDPR...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28623282/a-nationwide-study-of-severe-and-protracted-diarrhoea-in-patients-with-primary-immunodeficiency-diseases
#2
Wen-I Lee, Chien-Chang Chen, Tang-Her Jaing, Liang-Shiou Ou, Chuen Hsueh, Jing-Long Huang
Diarrhoea lasting longer than 14 days and failing to respond to conventional management is defined as severe and protracted diarrhoea (SD). In this study, we investigated the prevalence, pathogens and prognosis of SD in primary immunodeficiency diseases (PIDs). Among 246 patients with predominantly paediatric-onset PIDs from 2003-2015, 21 [Btk (six), IL2RG (four), WASP, CD40L, gp91 (three each), gp47, RAG2 (one each)] and five [CVID (four), SCID (one)] without identified mutations had SD before prophylactic treatment...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28581455/attenuation-of-rna-viruses-by-redirecting-their-evolution-in-sequence-space
#3
Gonzalo Moratorio, Rasmus Henningsson, Cyril Barbezange, Lucia Carrau, Antonio V Bordería, Hervé Blanc, Stephanie Beaucourt, Enzo Z Poirier, Thomas Vallet, Jeremy Boussier, Bryan C Mounce, Magnus Fontes, Marco Vignuzzi
RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential. We describe a strategy to attenuate RNA viruses by altering their evolutionary potential. We rationally altered the genomes of Coxsackie B3 and influenza A viruses to redirect their evolutionary trajectories towards detrimental regions in sequence space. Specifically, viral genomes were engineered to harbour more serine and leucine codons with nonsense mutation targets: codons that could generate Stop mutations after a single nucleotide substitution...
June 5, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28579231/optimized-production-and-purification-of-coxsackievirus-b1-vaccine-and-its-preclinical-evaluation-in-a-mouse-model
#4
Minna M Hankaniemi, Olli H Laitinen, Virginia M Stone, Amirbabak Sioofy-Khojine, Juha A E Määttä, Pär G Larsson, Varpu Marjomäki, Heikki Hyöty, Malin Flodström-Tullberg, Vesa P Hytönen
Coxsackie B viruses are among the most common enteroviruses, causing a wide range of diseases. Recent studies have also suggested that they may contribute to the development of type 1 diabetes. Vaccination would provide an effective way to prevent CVB infections, and the objective of this study was to develop an efficient vaccine production protocol for the generation of novel CVB vaccines. Various steps in the production of a formalin-inactivated Coxsackievirus B1 (CVB1) vaccine were optimized including the Multiplicity Of Infection (MOI) used for virus amplification, virus cultivation time, type of cell growth medium, virus purification method and formulation of the purified virus...
June 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28574589/enterovirus-genotypes-among-patients-with-severe-acute-respiratory-illness-influenza-like-illness-and-asymptomatic-individuals-in-south-africa-2012-2014
#5
Orienka Hellferscee, Stefano Tempia, Sibongile Walaza, Ebrahim Variava, Halima Dawood, Nicole Wolter, Shabir A Madhi, Mignon du Plessis, Cheryl Cohen, Florette K Treurnicht
Enteroviruses can cause outbreaks of severe acute respiratory illness (SARI) and EV-A, -B, -C and -D species have different pathogenic profiles and circulation patterns. We aimed to characterize and determine the prevalence of enterovirus genotypes among South African patients with respiratory illness and controls during June 2012 to July 2014. Syndromic SARI and influenza-like illness (ILI) surveillance was performed at two sentinel sites. At each site nasopharyngeal/oropharyngeal specimens were collected from SARI and ILI patients as well as controls...
June 2, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28540170/indole-alkaloid-sulfonic-acids-from-an-aqueous-extract-of-isatis-indigotica-roots-and-their-antiviral-activity
#6
Lingjie Meng, Qinglan Guo, Yufeng Liu, Minghua Chen, Yuhuan Li, Jiandong Jiang, Jiangong Shi
Six new indole alkaloid sulfonic acids (1-6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28539455/functional-consequences-of-rna-5-terminal-deletions-on-coxsackievirus-b3-rna-replication-and-ribonucleoprotein-complex-formation
#7
Nicolas Lévêque, Magali Garcia, Alexis Bouin, Joseph H C Nguyen, Genevieve P Tran, Laurent Andreoletti, Bert L Semler
Group B coxsackieviruses are responsible for chronic cardiac infections. However, the molecular mechanisms by which the virus can persist in the human heart long after the signs of acute myocarditis have abated are still not completely understood. Recently, coxsackievirus B3 strains with 5' terminal deletions in genomic RNAs were isolated from a patient suffering from idiopathic dilated cardiomyopathy, suggesting that such mutant viruses may be the forms responsible for persistent infection. These deletions lacked portions of 5' stem-loop I, which is an RNA secondary structure required for viral RNA replication...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28533530/the-impact-of-hand-foot-and-mouth-disease-control-policies-in-singapore-a-qualitative-analysis-of-public-perceptions
#8
Karen Siegel, Alex R Cook, Hanh La
Hand foot and mouth disease (HFMD) is a widespread pediatric disease in Asia. Most cases are relatively mild and caused by Coxsackie viruses, but in epidemics caused by Enterovirus 71, severe complications can occur. In response to the deaths of dozens of children in a 1997 outbreak (Podin in BMC Public Health 6:180,1 Abubakar in Virus Res 61(1):1-9,2 WHO in3), Singapore practices childcare centre surveillance, case-isolation, and short-term closure of centres. We conducted 44 in-depth interviews with teachers, principals, and parents at four childcare centres in Singapore to better understand experiences with current control policies...
May 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28511156/the-role-of-the-persistent-enterovirus-infection-in-development-of-acute-stroke
#9
Natalia G Andriushkova, Nataliia S Turchyna, Vadym A Poniatowski, Ludmyla V Dolinchuk, Valentyna V Melnyk, Volodymyr P Shyrobokov, Nataliia V Zakharchenko
INTRODUCTION: The role of enteroviruses in development of dilated cardiomyopathy, myocardial infarction, myocarditis, pericarditis is known. THE AIM: To examine the role of chronic enterovirus infections in development of acute stroke. MATERIAL AND METHODS: Blood samples from 72 patients with acute stroke (study group) and 35 patients without vascular disease (control group) were investigated by reverse transcription polymerase chain reaction for the presence of enterovirus RNA, by using virological method to detect enteroviruses, by ELISA for the levels of IgM and IgG antibodies to enteroviruses...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28475367/diglycosidic-indole-alkaloid-derivatives-from-an-aqueous-extract-of-isatis-indigotica-roots
#10
Ling-Jie Meng, Qing-Lan Guo, Cheng-Bo Xu, Cheng-Gen Zhu, Yu-Feng Liu, Ming-Hua Chen, Sheng Lin, Yu-Huan Li, Jian-Dong Jiang, Jian-Gong Shi
Six new indole alkaloid diglycosides named isatigotindolediosides A-F (1-6), along with three known analogs (7-9), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures including the absolute configurations were determined by comprehensive spectroscopic data analysis, combined with enzyme or acid hydrolysis, and comparison of experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. In the preliminary assays, compounds 3, 5, and 8 showed antiviral activity against Coxsackie virus B3...
May 5, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28468063/-health-related-quality-of-life-on-severe-hand-foot-and-mouth-disease-patients
#11
Y M Zheng, J Yang, Q H Liao
Objective: To evaluate the health related quality of life (HRQoL) for severe hand, foot and mouth disease (HFMD) patients with different complications. Methods: A national telephone interview under the EQ-5D proxy2 questionnaire (EQ-SD and EQ-VAS), was conducted to obtain the HRQoL of lab-confirmed severe HFMD patients, aged between six months and five-year-olds from the national communicable disease surveillance system from January 1, 2012 to December 31, 2013. Results: A total of 685 severe HFMD cases were included in the study...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28435072/development-of-a-pseudovirus-based-assay-for-measuring-neutralizing-antibodies-against-coxsackievirus-b5
#12
Pan Chen, Xing Wu, Yao Su, Xiaotian Hao, Qunying Mao, Zhenglun Liang
Coxsackievirus B5 (CV-B5), an important Coxsackie B virus from genus Enteroviruse within the family Picornaviridae, has also been isolated from Hand, Foot, and Mouth Disease (HFMD) patients, and often associated with neurological manifestations. In this study, we found out that Coxsackievirus B3 (CV-B3) replicon RNA could be encapsidated with CV-B5 capsid to assemble infectious CV-B5 pseudovirus. We then utilized this single round infection system of CV-B5 to develop a neutralizing antibody quantification assay...
April 20, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28370198/diclofenac-based-hydrazones-and-spirothiazolidinones-synthesis-characterization-and-antimicrobial-properties
#13
Ayşe Kocabalkanlı, Gökçe Cihan-Üstündağ, Lieve Naesens, Emel Mataracı-Kara, Mebble Nassozi, Gültaze Çapan
We report here the synthesis, structural characterization, and biological evaluation of novel diclofenac-based hydrazone (4a-f) and spirothiazolidinone (5a-f, 6a-f) derivatives designed as potential antimicrobial agents. The compounds were evaluated in vitro for their antiviral activity against a wide spectrum of DNA and RNA viruses. They were further screened in vitro against different strains of bacteria and fungi. The hydrazone derivatives, 4a and 4c-f, were found to be active against herpesviruses (HSV-1, HSV-2, and HSV-1 TK(-) ), vaccinia virus, and Coxsackie B4 virus, with EC50 values between 6...
March 30, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28359509/autosomal-recessive-cardiomyopathy-presenting-as-acute-myocarditis
#14
Serkan Belkaya, Amy R Kontorovich, Minji Byun, Sonia Mulero-Navarro, Fanny Bajolle, Aurelie Cobat, Rebecca Josowitz, Yuval Itan, Raphaelle Quint, Lazaro Lorenzo, Soraya Boucherit, Cecile Stoven, Sylvie Di Filippo, Laurent Abel, Shen-Ying Zhang, Damien Bonnet, Bruce D Gelb, Jean-Laurent Casanova
BACKGROUND: Myocarditis is inflammation of the heart muscle that can follow various viral infections. Why children only rarely develop life-threatening acute viral myocarditis (AVM), given that the causal viral infections are common, is unknown. Genetic lesions might underlie such susceptibilities. Mouse genetic studies demonstrated that interferon (IFN)-α/β immunity defects increased susceptibility to virus-induced myocarditis. Moreover, variations in human TLR3, a potent inducer of IFNs, were proposed to underlie AVM...
April 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28352303/paediatric-virology-a-rapidly-increasing-educational-challenge
#15
Ioannis N Mammas, Maria Theodoridou, Anna Kramvis, Prakash Thiagarajan, Sharryn Gardner, Georgia Papaioannou, Angeliki Melidou, Maria Koutsaki, Georgia Kostagianni, Vassilis Achtsidis, Chryssie Koutsaftiki, Marcos Calachanis, Apostolos Zaravinos, Anne Greenough, Demetrios A Spandidos
The '2nd Workshop on Paediatric Virology', which took place on Saturday the 8th of October 2016 in Athens, Greece, provided an overview on recent views and advances on Paediatric Virology. Emphasis was given to HIV-1 management in Greece, a country under continuous financial crisis, hepatitis B vaccination in Africa, treatment options for hepatitis C virus in childhood, Zika virus in pregnancy and infancy, the burden of influenza on childhood, hand-foot-mouth disease and myocarditis associated with Coxsackie viruses...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28303224/aromatic-compounds-from-an-aqueous-extract-of-ban-lan-gen-and-their-antiviral-activities
#16
Yufeng Liu, Minghua Chen, Qinglan Guo, Yuhuan Li, Jiandong Jiang, Jiangong Shi
A pair of new diphenyl glycerol ether enantiomers (-)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (-)-(R)- and (+)-(S)-isatindigotrioic acid [(-)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (-)-1 and (+)-1 were assigned based on the CD exciton chirality method...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28298229/a-novel-benzo-heterocyclic-amine-derivative-n30-inhibits-influenza-virus-replication-by-depression-of-inosine-5-monophospate-dehydrogenase-activity
#17
Jin Hu, Linlin Ma, Huiqiang Wang, Haiyan Yan, Dajun Zhang, Zhuorong Li, Jiandong Jiang, Yuhuan Li
BACKGROUD: Influenza virus is still a huge threat to the world-wide public health. Host inosine-5'- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target to inhibit the replication of viruses. Herein, we evaluated antiviral activity of a benzo-heterocyclic amine derivative N30, which was designed to inhibit IMPDH. RESULTS: The results demonstrated that N30 inhibited the replication of H1N1, H3N2, influenza B viruses, including oseltamivir and amantadine resistant strains in vitro...
March 15, 2017: Virology Journal
https://www.readbyqxmd.com/read/28263801/umifenovir-effectively-inhibits-il-10-dependent-persistent-coxsackie-b4-virus-infection
#18
Shilin Zhang, Chenyang Zhi, Hongrui Li, Dianshuai Huang, Qingjie Fan, Jiuwei Cui, Chongyang Liang
Coxsackie virus cannot be completely eliminated due to restrictive replication and impaired immune response, thus causing persistent infection. IL-10 plays a decisive role in the course of persistent viral infection. Umifenovir is a broad-spectrum antiviral drug, with certain treatment effects on Coxsackie virus infection. Previously, we showed that in addition to inhibiting Coxsackie B4 (CVB4) infection, Umifenovir also down-regulates IL-10 induced by persistent CVB4 virus infection in vitro and in vivo...
March 2, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28218574/corrigendum-three-capsid-amino-acids-notably-influence-coxsackie-b3-virus-stability
#19
Steven D Carson, Steven Tracy, Zac G Kaczmarek, Abdulaziz Alhazmi, Nora M Chapman
No abstract text is available yet for this article.
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28196967/coxsackie-myocarditis-and-hepatitis-with-reactivated-epstein-bar-virus-ebv-a-case-report
#20
Varunsiri Atti, Nathan M Anderson, Mathew B Day
BACKGROUND Myocarditis, defined as inflammation of myocardial tissue of the heart, is an uncommon cardiac presentation and is due to a variety of causes. It affects 1% of the US population, 50% of which is caused by coxsackie B virus. Cardiac tissue is the prime target, and destruction of myocardium results in cardiac failure with fluid overload. CASE REPORT Our patient was a 57-year-old woman with fever, headache, neck pain, and generalized malaise. Her white blood cell count was 13×10³ cells/mm³. Interestingly, lumbar puncture ruled out meningitis...
February 15, 2017: American Journal of Case Reports
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