keyword
https://read.qxmd.com/read/38457543/coxsackie-b-virus-induced-myocarditis-in-a-patient-with-a-history-of-lymphoma-a-case-report-and-review-of-literature
#1
JOURNAL ARTICLE
Qian Zhang, Jia Yuan, Wei Zhao, Weiwei Ouyang, Bowen Chen, Yehong Li, Junling Tao, Xianjun Chen, Guangsu Li, Zhendong Guo, Ying Liu
INTRODUCTION: In rare occasions, coxsackievirus infections can cause serious illness, such as encephalitis and myocarditis. The immunotherapies of cancer could increase the risk of myocarditis, especially when applying immune checkpoint inhibitors. Herein, we report a rare case of Coxsackie B virus-induced myocarditis in a patient with a history of lymphoma. CASE PRESENTATION: A 32-year-old woman was admitted to the hospital with recurrent fever for more than 20 days, and she had a history of lymphoma...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38388418/kaposi-varicelliform-eruption-an-unusual-presentation-caused-by-varicella-zoster-virus-in-a-healthy-adult-patient-a-case-report
#2
JOURNAL ARTICLE
Hassan El-Masry, Safia Essam, Hamed Gaber, Nour Shaheen, Ahmed Abdelbary, Naglaa Mohamed Sayed, Salma Samir Omar
BACKGROUND: Kaposi Varicelliform Eruptions (KVE), also known as eczema herpeticum, is a rare and potentially life-threatening dermatological condition primarily attributed to herpes simplex virus (HSV) infection, with less frequent involvement of Coxsackie A16, vaccinia, Varicella Zoster, and smallpox viruses. Typically associated with pre-existing skin diseases, especially atopic dermatitis, KVE predominantly affects children but can manifest in healthy adults. Characterized by painful clusters of vesicles and sores on the skin and mucous membranes, it often masquerades as other dermatological disorders...
February 22, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38369573/safety-tolerability-and-immunogenicity-of-prv-101-a-multivalent-vaccine-targeting-coxsackie-b-viruses-cvbs-associated-with-type-1-diabetes-a-double-blind-randomised-placebo-controlled-phase-i-trial
#3
RANDOMIZED CONTROLLED TRIAL
Heikki Hyöty, Susanna Kääriäinen, Jutta E Laiho, Gail M Comer, Wei Tian, Taina Härkönen, Jussi P Lehtonen, Sami Oikarinen, Leena Puustinen, Michele Snyder, Francisco León, Mika Scheinin, Mikael Knip, Miguel Sanjuan
AIMS/HYPOTHESIS: Infection with coxsackie B viruses (CVBs) can cause diseases ranging from mild common cold-type symptoms to severe life-threatening conditions. CVB infections are considered to be prime candidates for environmental triggers of type 1 diabetes. This, together with the significant disease burden of acute CVB infections and their association with chronic diseases other than diabetes, has prompted the development of human CVB vaccines. The current study evaluated the safety and immunogenicity of the first human vaccine designed against CVBs associated with type 1 diabetes in a double-blind randomised placebo-controlled Phase I trial...
May 2024: Diabetologia
https://read.qxmd.com/read/38353537/strain-specific-requirements-of-susceptibility-to-rhesus-enteric-calicivirus-infection
#4
JOURNAL ARTICLE
Tibor Farkas, Vinod Srivastava
Recently, we identified the coxsackie and adenovirus receptor (CAR) as the entry receptor for rhesus enteric calicivirus (ReCV) isolate FT285 and demonstrated that co-expression of the CAR and the type B histo-blood group antigen (HBGA) is required to convert the resistant CHO cell line susceptible to infection. To address whether the CAR is also the functional entry receptor for other ReCV isolates and the requirement for specific HBGAs or other glycans, here we used a panel of recombinant CHO cell lines expressing the CAR and the type A, B, or H HBGAs alone or in combination...
February 14, 2024: Journal of Virology
https://read.qxmd.com/read/38323814/structural-insights-into-the-interaction-between-adenovirus-c5-hexon-and-human-lactoferrin
#5
JOURNAL ARTICLE
Arun Dhillon, B David Persson, Alexander N Volkov, Hagen Sülzen, Alan Kádek, Petr Pompach, Sami Kereïche, Martin Lepšík, Katarina Danskog, Charlotte Uetrecht, Niklas Arnberg, Sebastian Zoll
Adenovirus (AdV) infection of the respiratory epithelium is common but poorly understood. Human AdV species C types, such as HAdV-C5, utilize the Coxsackie-adenovirus receptor (CAR) for attachment and subsequently integrins for entry. CAR and integrins are however located deep within the tight junctions in the mucosa where they would not be easily accessible. Recently, a model for CAR-independent AdV entry was proposed. In this model, human lactoferrin (hLF), an innate immune protein, aids the viral uptake into epithelial cells by mediating interactions between the major capsid protein, hexon, and yet unknown host cellular receptor(s)...
February 7, 2024: Journal of Virology
https://read.qxmd.com/read/38236264/retinopathy-associated-with-coxsackie-b-virus-infection
#6
JOURNAL ARTICLE
Adam Hanif, Aristomenis Thanos
No abstract text is available yet for this article.
January 1, 2024: JAMA Ophthalmology
https://read.qxmd.com/read/38074126/eucalyptus-derived-essential-oils-alleviate-microbes-and-modulate-inflammation-by-suppressing-superoxide-and-elastase-release
#7
JOURNAL ARTICLE
Shaimaa Fayez, Mariam I Gamal El-Din, Saad A Moghannem, Faizul Azam, Mohamed El-Shazly, Michal Korinek, Yu-Li Chen, Tsong-Long Hwang, Nouran M Fahmy
The Eucalyptus tree, belonging to the myrtle family, grows all over the world for its pharmaceutical and industrial benefits. In this article, we present a comparative analysis of the chemical composition of the hydrodistilled oils obtained from three different Eucalyptus species growing in Egypt viz. E. citriodora , E. camaldulensis , and E. ficifolia . Gas Chromatography-Mass Spectrometric guided analysis resulted in the identification of a total of 20 metabolites in E. citriodora oil with citronellal (54...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38021765/unusual-presentation-of-coxsackievirus-b-and-methicillin-sensitive-staphylococcus-aureus-cellulitis-causing-sepsis
#8
Britton A Ethridge, Cory J Dixon, Paul Q Vu, Michael B Steadman, Aaron P Tillman, Natalie S Barefield, Matthew C Ragan
The clinical association between Coxsackievirus B (CVB) and methicillin-sensitive Staphylococcus aureus (MSSA) has not been well established in the current literature. Here, we report a case of a 29-year-old male who presented with fever and malaise 24 hours after noticing a pruritic lesion on the anterior foreleg that resembled a mosquito bite. After multiple ED visits, laboratory studies, and imaging tests, the patient was admitted for treatment of high fevers and pancytopenia. The final diagnosis was viral sepsis complicated by co-infection with MSSA...
October 2023: Curēus
https://read.qxmd.com/read/37987819/-lethal-lymphocytic-myocarditis-an-underestimated-diagnosis-in-infancy-and-childhood
#9
REVIEW
R Dettmeyer
In the past, histological diagnosis of (post-)viral myocarditis was based on the so-called Dallas criteria, which have been criticized because of high interobserver variability and sampling error. Immunohistochemical qualification and quantification of interstitial intramyocardial leucocytes was established and standard values concerning adults were published. Fatal casualties due to a viral myocarditis are rare as far as babies and children are concerned (sudden unexpected death in infancy; SUDI). Cases of sudden unexpected death in the first year of life are frequently regarded as sudden infant death syndrome (SIDS)...
November 21, 2023: Pathologie (Heidelb)
https://read.qxmd.com/read/37970829/clinical-features-and-outcomes-of-omicron-associated-croup-in-children
#10
JOURNAL ARTICLE
Yue Huang, Shuhua Su, Zhengmin Xu, Wenxia Chen
Objective: This study was aimed to describe the clinical features and outcomes of Omicron-associated croup in children. Methods: A total of 105 children aged 3-60 months (median age 11 months) with coronavirus disease 2019 (COVID-19) and cough were admitted to our hospital from December 16, 2022, to December 31, 2022. Their clinical features, treatment, and outcomes were reviewed. These children were followed up for 8 months. Results: Among the cases, 5 had complex medical histories, while the other children were generally healthy...
November 16, 2023: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/37944448/ngr-bearing-human-adenovirus-type-5-infects-cells-in-flotillin-or-caveolin-mediated-manner-depending-on-the-ngr-insertion-site
#11
JOURNAL ARTICLE
Ksenija Božinović, Davor Nestić, Elodie Grellier, Najat Raddi, Gaétan Cornilleau, Andreja Ambriović-Ristov, Karim Benihoud, Dragomira Majhen
Human adenoviruses represent attractive candidates for the design of cancer gene therapy vectors. Modification of adenovirus tropism by incorporating a targeting ligand into the adenovirus capsid proteins allows retargeting of adenovirus towards the cells of interest. Human adenovirus type 5 (HAdV-C5) bearing NGR containing peptide (CNGRCVSGCAGRC) inserted into the fiber (AdFNGR) or the hexon (AdHNGR) protein demonstrated an increased transduction of endothelial cells showing expression of aminopeptidase N, also known as CD13, and αvβ3 integrin both present on tumor vasculature, indicating that NGR-bearing adenoviruses could be used as tools for anti-angiogenic cancer therapy...
November 3, 2023: Biomater Adv
https://read.qxmd.com/read/37928846/antimicrobial-and-antiviral-evaluation-of-compounds-from-holoptelea-integrifolia-in-silico-supported-in-vitro-study
#12
JOURNAL ARTICLE
Hala Sh Mohammed, Eman F S Taha, Fatma S Mahrous, Rehab Sabour, Marwa M Abdel-Aziz, Lotfy D Ismail
Holoptelea integrifolia , also known as the Indian Elm Tree, has been used in Ayurvedic medicine for its medicinal properties. In this study, two biologically active metabolites, 5(6) dihydrostigmast 22en 3- O -β-glucoside (DHS) and 1- O -eicosanoyl glycerol-2'- O -β-galactouronic (EGG), were isolated for the first time from the n -butanol fraction of H. integrifolia using a chromatographic technique and identified by NMR, and HRESI-MS. The antiviral and multidrug-resistant activities of these metabolites were evaluated as well as the n -butanol fraction...
October 31, 2023: RSC Advances
https://read.qxmd.com/read/37906052/inhibition-of-lysosome-tethered-ragulator-rag-3d-complex-restricts-the-replication-of-enterovirus-71-and-coxsackie-a16
#13
JOURNAL ARTICLE
Xinhui Wang, Zhilin Hu, Wei Zhang, Shuwei Wu, Yongjin Hao, Xia Xiao, Jingjing Li, Xiaoliang Yu, Chengkui Yang, Jingfeng Wang, Huiying Zhang, Feng Ma, Weifeng Shi, Jianwei Wang, Xiaobo Lei, Xiaohu Zhang, Sudan He
Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) are two major causative agents of hand, foot, and mouth disease (HFMD) in young children. However, the mechanisms regulating the replication and pathogenesis of EV71/CVA16 remain incompletely understood. We performed a genome-wide CRISPR-Cas9 knockout screen and identified Ragulator as a mediator of EV71-induced apoptosis and pyroptosis. The Ragulator-Rag complex is required for EV71 and CVA16 replication. Upon infection, the Ragulator-Rag complex recruits viral 3D protein to the lysosomal surface through the interaction between 3D and RagB...
December 4, 2023: Journal of Cell Biology
https://read.qxmd.com/read/37898798/evaluation-of-viral-infection-as-an-etiology-of-me-cfs-a-systematic-review-and-meta-analysis
#14
REVIEW
Jae-Hyun Hwang, Jin-Seok Lee, Hyeon-Muk Oh, Eun-Jung Lee, Eun-Jin Lim, Chang-Gue Son
BACKGROUND: Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a long-term disabling illness without a medically explained cause. Recently during COVID-19 pandemic, many studies have confirmed the symptoms similar to ME/CFS in the recovered individuals. To investigate the virus-related etiopathogenesis of ME/CFS, we conducted a systematic assessment of viral infection frequency in ME/CFS patients. METHODS: We conducted a comprehensive search of PubMed and the Cochrane Library from their inception through December 31, 2022, using selection criteria of viral infection prevalence in ME/CFS patients and controls...
October 28, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37881026/first-description-and-phylogenetic-analysis-of-coxsackie-virus-a-non-polio-enteroviruses-and-parechoviruses-a-in-south-sudanese-children
#15
JOURNAL ARTICLE
Karen Couderé, Kimberley Benschop, Astrid van Steen, Jaco J Verweij, Suzan Pas, Jeroen Cremer, Arthur W D Edridge, Gasim O E Abd-Elfarag, Michaël B van Hensbroek, Dasja Pajkrt, Jean-Luc Murk, Katja C Wolthers
Enteroviruses (EV) and parechoviruses A (PeV-A) are commonly circulating viruses able to cause severe disease. Surveillance studies from sub-Saharan Africa are limited and show high but variable infection rates and a high variation in genotypes. This is the first study to describe EV and PeV-A circulation in children in South Sudan. Of the fecal samples collected, 35% and 10% were positive for EV and PeV-A, respectively. A wide range of genotypes were found, including several rarely described EV and PeV-A types...
October 2023: Journal of Medical Virology
https://read.qxmd.com/read/37859383/-analysis-of-the-common-respiratory-viruses-in-children-with-acute-respiratory-infection-in-a-hospital-in-lanzhou-city-from-2021-to-2022
#16
JOURNAL ARTICLE
L Y Wang, Z Y Liu, J J Yin, L W Yan, P P Wang, Y S Shi, Y Zhang, H M Zhao
To explore the situation of 8 common respiratory pathogens in children with acute respiratory infection (ARI) from 2021 to 2022.The retrospective study selected 8 710 ARI patients from September 2021 to August 2022 in the Maternal and Child Health Hospital of Gansu Province as the study object, patients aged 0 to 17 years old, including 5 048 male children and 3 662 female children. Indirect immunofluorescence was used to detect 8 common respiratory pathogens, including influenza virus A (FluA), influenza virus B (FluB), parainfluenza virus (PIV), respiratory syncytial virus (RSV), adenovirus (ADV), Mycoplasma pneumoniae (MP), Chlamydia pneumoniae (CP), and Coxsackie virus group B (CoxB) IgM antibodies...
October 6, 2023: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/37846284/coxsackie-b-virus-induced-cardiac-tamponade-and-adrenal-insufficiency
#17
Su Hyun Jeong, Fernando J Fuentes
We report a case involving a young male patient without a significant medical history who exhibited symptoms of fatigue, shortness of breath, chest and back pain, and syncope with vomiting. He was found to have adrenal insufficiency and cardiac tamponade requiring pericardiocentesis. Further inpatient workup revealed the patient had positive IgM and IgG antibody titers for the coxsackie B virus, which we believe caused his presentation. The coxsackie B virus strain can cause mild gastrointestinal to more severe cardiac and neurological complications, including meningitis and myocarditis...
September 2023: Curēus
https://read.qxmd.com/read/37806501/experimental-infection-of-foot-and-mouth-disease-virus-fmdv-upregulates-the-expression-of-coxsackie-and-adenovirus-receptor-car-in-the-myocardium-of-suckling-mice
#18
JOURNAL ARTICLE
Mahadappa Priyanka, H B Ranjitha, M Karikalan, S Chandramohan, Subhasmitha Behera, V Gnanavel, R P Tamilselvum, V Umapathi, H J Dechamma, Narayanan Krishnaswamy
The relative overexpression of coxsackie and adenoviral receptor (CAR) predisposes children to viral myocarditis. As the foot and mouth disease virus (FMDV) causes fatal myocarditis in calves, lambs, and piglets and belongs to the same family as the Coxsackie virus, we investigated the role of CAR in FMDV induced myocarditis in the suckling mice model. Swiss albino suckling mice of 5 days (n = 24) were divided into two equal groups. One group was inoculated with suckling mice adapted FMDV serotype O at 10 LD50 , while the other group served as uninfected control...
October 6, 2023: Microbial Pathogenesis
https://read.qxmd.com/read/37791760/rapid-and-sensitive-on-site-detection-of-sars-cov-2-rna-from-environmental-surfaces-using-portable-laboratory-devices
#19
JOURNAL ARTICLE
Kouichi Kitamura, Minami Kikuchi Ueno, Hiromu Yoshida
Monitoring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA on inanimate surfaces plays a crucial role in environmental surveillance, enabling the indirect detection of infected individuals and facilitating rapid infection control responses. However, developing a practical on-site, end-to-end method for detection remains a challenge. In this study, we established protocols for on-site detection of SARS-CoV-2 RNA on surfaces using two portable laboratory devices: The PicoGene PCR1100 and Bento Lab...
October 4, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37768558/increased-reports-of-severe-myocarditis-associated-with-enterovirus-infection-in-neonates-united-kingdom-27-june-2022-to-26-april-2023
#20
JOURNAL ARTICLE
Anika Singanayagam, Catherine Moore, Susannah Froude, Cristina Celma, Julia Stowe, Erjola Hani, Khuen Foong Ng, Peter Muir, Marion Roderick, Simon Cottrell, David F Bibby, Barry Vipond, Sophie Gillett, Peter J Davis, Jack Gibb, Mai Barry, Phillippa Harris, Frances Rowley, Jiao Song, Ananda Giri Shankar, Danielle McMichael, Jonathan M Cohen, Abirami Manian, Ciaran Harvey, Louise Shaw Primrose, Stefanie Wilson, Declan T Bradley, Karthik Paranthaman, Stuart Beard, Maria Zambon, Mary Ramsay, Vanessa Saliba, Shamez Ladhani, Christopher Williams
Enteroviruses are a common cause of seasonal childhood infections. The vast majority of enterovirus infections are mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is a rare complication of enterovirus infection. Between June 2022 and April 2023, twenty cases of severe neonatal enteroviral myocarditis caused by coxsackie B viruses were reported in the United Kingdom. Sixteen required critical care support and two died. Enterovirus PCR on whole blood was the most sensitive diagnostic test...
September 2023: Euro Surveillance
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