keyword
https://read.qxmd.com/read/38376142/statement-of-retraction-the-protective-effects-of-olmesartan-against-interleukin-29-il-29-induced-type-2-collagen-degradation-in-human-chondrocytes
#1
(no author information available yet)
No abstract text is available yet for this article.
December 2024: Bioengineered
https://read.qxmd.com/read/38290406/evaluation-of-the-serum-levels-of-ccl2-ccl3-and-il-29-after-first-and-second-administrations-of-the-covid-19-vaccine-oxford-astrazeneca
#2
JOURNAL ARTICLE
Zahra Bagheri-Hosseinabadi, Ayat Kaeidi, Mahdi Rezvani, Gholamhossein Taghipour Khaje Sharifi, Mitra Abbasifard
BACKGROUND: Previous studies show that chemokines and cytokines play a very important role in eliciting an appropriate response against viruses. Vaccination causes inflammation in the person receiving the vaccine, accompanied with production of inflammatory molecules by immune cells. The more and better the production and expression of chemokines and cytokines by immune cells, the better the response of the acquired immune system. Chemokines and cytokines are critical in promoting the innate immune response against the COVID-19...
January 28, 2024: Immunobiology
https://read.qxmd.com/read/38281234/up-and-away-with-cervical-cancer-il-29-is-a-promising-cytokine-for-immunotherapy-of-cervical-cancer-due-to-its-powerful-upregulation-of-p18-p27-and-trailr1
#3
JOURNAL ARTICLE
Jackie L Ha, Erin Kaser, Tianyun Guan, Trenton G Mayberry, Luke A Smith, Kyle D'mello, Qian Bai, Mark R Wakefield, Lijun Dong, Yujiang Fang
Cervical cancer is one of the most common types of female cancers worldwide. IL-29 is an interesting cytokine in the IFNλ family. Its role in the pathogenesis of neoplasia is complicated and has been studied in other cancers, such as lung cancer, gastric cancer, and colorectal cancer. IL-29 has been previously reported to promote the growth of pancreatic cancer. However, the direct role of IL-29 in cervical cancer has not been studied yet. This study was performed to investigate the direct effect on cervical cancer cell growth...
January 28, 2024: Medical Oncology
https://read.qxmd.com/read/38271827/ifnl1-rs30461-polymorphism-as-a-risk-factor-for-covid-19-severity-a-cross-sectional-study
#4
JOURNAL ARTICLE
Maha O Hammad, Mahmoud M Alseoudy, Asmaa M Borg, Ahmed El-Mesery, Mohamed Elgamal, Dalia A Abdelghany, Dina Elzeiny
INTRODUCTION: The molecular basis of the progression of some COVID-19 patients to worse outcomes is not entirely known. Interferons-lambda-1/interleukin-29 (IFN-λ1/IL-29) is a member of the type III IFNs with a strong antiviral activity. Given the scant data on the potential role of IFN-λ1/IL-29 in COVID-19, we investigated the association of IFN-λ1/IL-29 serum level and the IFNL1 single-nucleotide polymorphism (SNP) (rs30461) with severe course of COVID-19. MATERIAL AND METHODS: This cross-sectional study included 400 COVID-19 patients, in which 262 mild COVID-19 patients and 138 severe COVID-19 patients were recruited and compared...
January 24, 2024: Cytokine
https://read.qxmd.com/read/38266104/the-csf-1r-inhibitor-pexidartinib-affects-flt3-dependent-dc-differentiation-and-may-antagonize-durvalumab-effect-in-patients-with-advanced-cancers
#5
JOURNAL ARTICLE
Aurélien Voissière, Carlos Gomez-Roca, Sylvie Chabaud, Céline Rodriguez, Axelle Nkodia, Justine Berthet, Laure Montane, Anne-Sophie Bidaux, Isabelle Treilleux, Lauriane Eberst, Catherine Terret, Iphigénie Korakis, Gwenaelle Garin, David Pérol, Jean-Pierre Delord, Christophe Caux, Bertrand Dubois, Christine Ménétrier-Caux, Nathalie Bendriss-Vermare, Philippe A Cassier
Tumor-associated macrophages (TAMs) are a critical determinant of resistance to PD-1/PD-L1 blockade. This phase 1 study (MEDIPLEX, NCT02777710) investigated the safety and efficacy of pexidartinib, a CSF-1R-directed tyrosine kinase inhibitor (TKI), and durvalumab (anti-PD-L1) in patients with advanced colorectal and pancreatic carcinoma with the aim to enhance responses to PD-L1 blockade by eliminating CSF-1-dependent suppressive TAM. Forty-seven patients were enrolled. No unexpected toxicities were observed, one (2%) high microsatellite instability CRC patient had a partial response, and seven (15%) patients experienced stable disease as their best response...
January 24, 2024: Science Translational Medicine
https://read.qxmd.com/read/38006022/bestatin-a-pluripotent-immunomodulatory-small-molecule-drives-robust-and-long-lasting-immune-responses-as-an-adjuvant-in-viral-vaccines
#6
JOURNAL ARTICLE
Hyeong Won Kim, Mi-Kyeong Ko, So Hui Park, Seokwon Shin, Su-Mi Kim, Jong-Hyeon Park, Min Ja Lee
An inactivated whole-virus vaccine is currently used to prevent foot-and-mouth disease (FMD). Although this vaccine is effective, it offers short-term immunity that requires regular booster immunizations and has several side effects, including local reactions at the vaccination site. To address these limitations, herein, we evaluated the efficacy of bestatin as a novel small molecule adjuvant for inactivated FMD vaccines. Our findings showed that the FMD vaccine formulated with bestatin enhanced early, intermediate-, and particularly long-term immunity in experimental animals (mice) and target animals (pigs)...
November 4, 2023: Vaccines
https://read.qxmd.com/read/37878533/exploring-cytokine-networks-in-resistant-hypertension
#7
JOURNAL ARTICLE
Linda P Bolin, Patricia B Crane, Laura H Gunn
BACKGROUND: Controlling high blood pressure (BP) continues to be a major concern because the associated complications can lead to an increased risk of heart, brain, and kidney disease. Those with hypertension, despite lifestyle and diet modifications and pharmacotherapy, defined as resistant hypertension, are at increased risk for further risk for morbidity and mortality. Understanding inflammation in this population may provide novel avenues for treatment. OBJECTIVES: This study aimed to examine a broad range of cytokines in adults with cardiovascular disease and identify specific cytokines associated with resistant hypertension...
October 26, 2023: Nursing Research
https://read.qxmd.com/read/37773570/alpha-fetoprotein-as-a-factor-of-differentiation-and-functional-activity-of-myeloid-derived-suppressor-cells
#8
JOURNAL ARTICLE
K Yu Shardina, S A Zamorina, V P Timganova, M S Bochkova, S V Uzhviyuk, V A Chereshnev
We studied the role of alpha-fetoprotein (AFP) in regulation of differentiation and functional activity of human myeloid-derived suppressor cells (MDSC) in vitro. To obtain MDSC, CD11b+ cells were isolated from the peripheral blood of healthy donors followed by cytokine induction (IL-1β+GM-CSF) into the MDSC phenotype. The cell functions were assessed by the expression of indoleamine 2,3-dioxygenase (IDO) and arginase-1 (Arg1) and cytokine profile of the cell cultures. Native AFP did not affect the total number of MDSC and the percentage of polymorphonuclear MDSC (PMN-MDSC), but increased the number of monocytic MDSC (M-MDSC)...
September 29, 2023: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/37738756/a-comparison-of-serum-inflammatory-parameters-in-progressive-forms-of-multiple-sclerosis
#9
JOURNAL ARTICLE
Maria Nowak-Kiczmer, Natalia Niedziela, Zenon P Czuba, Paweł Sowa, Krzysztof Wierzbicki, Michał Lubczyński, Monika Adamczyk-Sowa
INTRODUCTION: Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central nervous system. Primary progressive MS (PPMS) is diagnosed in approximately 10-15 % of MS patients. Disease-modifying therapies (DMT) are less effective in modifying the course of progressive types of MS. It seems that inflammatory processes differ in the MS subtypes. OBJECTIVES: The objective of this study was to assess differences in the inflammatory parameters between PPMS and other courses of MS...
November 2023: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/37690425/importance-of-screening-severe-covid-19-patients-for-ifn-%C3%AE-1-il-6-and-anti-s1-igg-levels
#10
JOURNAL ARTICLE
Olcay Buse Kenanoğlu, Aytül Gül, Hüseyin Can, Muhammet Karakavuk, Sedef Erkunt Alak, Gülay Korukluoğlu, Ayşe Başak Altaş, Hüsnü Pullukçu, Aysu Değirmenci Döşkaya, Tuğba Karakavuk, Ceren Gül, Candan Çiçek, Mehmet Sezai Taşbakan, Akın Çinkooğlu, Cemal Ün, Adnan Yüksel Gürüz, Mahmut Avcı, Ercüment Karasulu, Şaban Tekin, Mert Döşkaya, Meltem Işıkgöz Taşbakan
Cytokine storm is an important cause of death in COVID-19 patients. A recent clinical study showed that administration of recombinant interferon lambda 1 (IFN-λ1 or IL-29) may prevent severe COVID-19. On the other hand, IL-6 has been associated as a prognostic marker of worsening for COVID-19 patients. The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies...
September 8, 2023: Cytokine
https://read.qxmd.com/read/37659419/dynamics-of-inflammatory-responses-after-sars-cov-2-infection-by-vaccination-status-in-the-usa-a-prospective-cohort-study
#11
JOURNAL ARTICLE
Xianming Zhu, Kelly A Gebo, Alison G Abraham, Feben Habtehyimer, Eshan U Patel, Oliver Laeyendecker, Thomas J Gniadek, Reinaldo E Fernandez, Owen R Baker, Malathi Ram, Edward R Cachay, Judith S Currier, Yuriko Fukuta, Jonathan M Gerber, Sonya L Heath, Barry Meisenberg, Moises A Huaman, Adam C Levine, Aarthi Shenoy, Shweta Anjan, Janis E Blair, Daniel Cruser, Donald N Forthal, Laura L Hammitt, Seble Kassaye, Giselle S Mosnaim, Bela Patel, James H Paxton, Jay S Raval, Catherine G Sutcliffe, Matthew Abinante, Patrick Broderick, Valerie Cluzet, Marie Elena Cordisco, Benjamin Greenblatt, Joann Petrini, William Rausch, David Shade, Karen Lane, Amy L Gawad, Sabra L Klein, Andrew Pekosz, Shmuel Shoham, Arturo Casadevall, Evan M Bloch, Daniel Hanley, David J Sullivan, Aaron A R Tobian
BACKGROUND: Cytokines and chemokines play a critical role in the response to infection and vaccination. We aimed to assess the longitudinal association of COVID-19 vaccination with cytokine and chemokine concentrations and trajectories among people with SARS-CoV-2 infection. METHODS: In this longitudinal, prospective cohort study, blood samples were used from participants enrolled in a multi-centre randomised trial assessing the efficacy of convalescent plasma therapy for ambulatory COVID-19...
September 2023: The Lancet. Microbe
https://read.qxmd.com/read/37611859/maternal-di-2-ethylhexyl-phthalate-exposure-elicits-offspring-ifn-%C3%AE-upregulation-insights-from-birth-cohort-murine-model-and-in-vitro-mechanistic-analysis
#12
JOURNAL ARTICLE
Fu-Chen Kuo, Mei-Lan Tsai, Shin-Ting Wu, Sih-Syuan Li, Chia-Fang Wu, Shu-Lin Wang, Michael W Y Chan, Jau-Ling Suen, Ming-Tsang Wu, Chih-Hsing Hung
Maternal exposure to di-(2-ethylhexyl)-phthalate (DEHP), an environmental endocrine disruptor, may lead to developmental immunotoxicity in offspring. The causal relationship and underlying mechanism require further study. A subset of Taiwan Maternal and Infant Cohort Study data (n = 283) was analyzed and found a significant association between urinary DEHP metabolite levels from the third trimester of pregnancy and plasma levels of IL-28 A and IL-29, named IFNλs, in cord blood. A trans-maternal murine model mimicking human DEHP exposure way showed that bone marrow-derived dendritic cells from maternal DEHP-exposed F1 offspring secreted higher IL-28 A levels than control cells, indicating a potential causal relationship...
August 21, 2023: Food and Chemical Toxicology
https://read.qxmd.com/read/37610337/the-cooperation-of-il-29-and-plga-nanoparticles-improves-the-protective-immunity-of-the-gd-1-dna-vaccine-against-herpes-simplex-virus-type-1-in-mice
#13
JOURNAL ARTICLE
Parisa Amir Kalvanagh, Hesam Karimi, Hoorieh Soleimanjahi, Massoumeh Ebtekar, Parviz Kokhaei, Zahra Matloubi, Roghieh Rahimi, Nazanin Atieh Kazemi-Sefat, Hajar Rajaei
In clinical practice, the low immunogenicity and low stability of the DNA plasmid vaccine candidates are two significant shortcomings in their application against infectious diseases. To overcome these two disadvantages, the plasmid expressing IL-29 (pIL-29) as a genetic adjuvant and polylactic-co-glycolic acid (PLGA) as a non-viral delivery system were used, respectively. In this study, the pIL-29 encapsulated in PLGA nanoparticles (nanoIL-29) and the pgD1 encapsulated in PLGA nanoparticles (nanoVac) were simultaneously applied to boost immunologic responses against HSV-1...
August 23, 2023: Immunological Investigations
https://read.qxmd.com/read/37589127/effects-of-monolaurin-on-intestinal-barrier-blood-biochemical-profile-immunity-and-antioxidant-function-in-porcine-epidemic-diarrhea-virus-infected-piglets
#14
JOURNAL ARTICLE
Chao Wang, Qian Zhang, Changzheng Ji, Yuyan Hu, Dan Yi, Tao Wu, Lei Wang, Di Zhao, Yongqing Hou
The effects of monolaurin (ML) on the health of piglets infected with porcine epidemic diarrhea virus (PEDV) has not been fully understood. This study aimed to investigate its role in blood biochemical profile, intestinal barrier function, antioxidant function and the expression of antiviral genes in piglets infected with PEDV. Thirty-two piglets were randomly divided into four groups: control group, ML group, PEDV group and ML + PEDV group. Piglets were orally administrated with ML at a dose of 100 mg/kg·BW for 7 days before PEDV infection...
August 17, 2023: British Journal of Nutrition
https://read.qxmd.com/read/37470105/sex-specific-differences-in-myocardial-injury-incidence-after-covid-19-mrna-1273-booster-vaccination
#15
JOURNAL ARTICLE
Natacha Buergin, Pedro Lopez-Ayala, Julia R Hirsiger, Philip Mueller, Daniela Median, Noemi Glarner, Klara Rumora, Timon Herrmann, Luca Koechlin, Philip Haaf, Katharina Rentsch, Manuel Battegay, Florian Banderet, Christoph T Berger, Christian Mueller
AIMS: To explore the incidence and potential mechanisms of oligosymptomatic myocardial injury following COVID-19 mRNA booster vaccination. METHODS AND RESULTS: Hospital employees scheduled to undergo mRNA-1273 booster vaccination were assessed for mRNA-1273 vaccination-associated myocardial injury, defined as acute dynamic increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration above the sex-specific upper limit of normal on day 3 (48-96 h) after vaccination without evidence of an alternative cause...
October 2023: European Journal of Heart Failure
https://read.qxmd.com/read/37465671/establishment-of-a-porcine-bronchial-epithelial-cell-line-and-its-application-to-study-innate-immunity-in-the-respiratory-epithelium
#16
JOURNAL ARTICLE
Kohtaro Fukuyama, Tao Zhuang, Eita Toyoshi, Fernanda Raya Tonetti, Sudeb Saha, Binghui Zhou, Wakako Ikeda-Ohtsubo, Keita Nishiyama, Hisashi Aso, Julio Villena, Haruki Kitazawa
In vitro culture models that precisely mirror the porcine respiratory epithelium are needed to gain insight into how pathogens and host interact. In this study, a new porcine bronchial epithelial cell line, designated as PBE cells, was established from the respiratory tract of a neonatal pig. PBE cells assumed a cobblestone-epithelial like morphology with close contacts between the cells when they reached confluence. The PBE cell line was characterized in terms of its expression of pattern recognition receptors (PRRs) and its ability to respond to the activation of the Toll-like receptor 3 (TLR3) and TLR4 signaling pathways, which are key PRRs involved in the defense of the respiratory epithelium against pathogens...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37434164/low-grade-inflammation-is-associated-with-a-heterogeneous-lipoprotein-subclass-profile-in-an-apparently-healthy-population-sample
#17
JOURNAL ARTICLE
Daniel L Pontzen, Martin Bahls, Diana Albrecht, Stephan B Felix, Marcus Dörr, Till Ittermann, Matthias Nauck, Nele Friedrich
BACKGROUND AND AIMS: Prevention measures for cardiovascular diseases (CVD) have shifted their focus from lipoproteins to the immune system. However, low-grade inflammation and dyslipidemia are tightly entangled. The objective of this study was to assess the relations between a broad panel of inflammatory biomarkers and lipoprotein subclass parameters. METHODS: We utilized data from the population-based Study of Health in Pomerania (SHIP-TREND, n = 403)...
July 11, 2023: Lipids in Health and Disease
https://read.qxmd.com/read/37394182/evaluation-of-exosomes-encapsulated-recombinant-interleukin-29-for-its-in-vitro-anticancer-studies
#18
JOURNAL ARTICLE
Nao Akusa Fujimura, Seerat E Fatima, Nadeem Ahmed, Muhammad Akram, Saad Tahir, Mohsin Ahmad Khan, Imran Amirzada, Tariq Nadeem, Hamid Bashir, Kausar Malik
Exosomes have recently been considered ideal biotherapeutic nanocarriers that broaden the frontiers of current drug delivery systems to overcome the shortcomings associated with cytokine-based immunotherapy. Using this approach, the current study aimed to assess anti-proliferative activity of purified IL-29 and exosomes encapsulated IL-29. The IL-29+pET-28a construct was transformed into Rosetta 2(DE3) cells which was used for the large-scale production of IL-29. Exosomes isolated from H1HeLa, and SF-767 cells using Total Exosome Isolation reagent were loaded with IL-29 via sonication...
June 30, 2023: Journal of Biotechnology
https://read.qxmd.com/read/37266881/enhanced-soluble-expression-of-active-recombinant-human-interleukin-29-using-champion-pet-sumo-system
#19
JOURNAL ARTICLE
Ayesha Munir, Nadeem Ahmed, Muhammad Akram, Nao Akusa Fujimura, Saad Tahir, Kausar Malik
Current research focuses on the soluble and high-level expression of biologically active recombinant human IL-29 protein in Escherichia coli. The codon-optimized IL-29 gene was cloned into the Champion™ pET SUMO expression system downstream of the SUMO tag under the influence of the T7 lac promoter. The expression of SUMO-fused IL-29 protein was compared in E. coli Rosetta 2(DE3), Rosetta 2(DE3) pLysS, and Rosetta-gami 2(DE3). The release of the SUMO fusion partner resulted in approximately 98 mg of native rhIL-29 protein with a purity of 99% from 1 l of fermentation culture...
June 2, 2023: Biotechnology Letters
https://read.qxmd.com/read/37147714/systematic-levels-of-il-29-and-microrna185-5p-were-not-associated-with-severe-covid-19-in-the-iranian-population
#20
JOURNAL ARTICLE
Omidreza Sarrafi, Ashraf Kariminik, Mohammad Kazemi Arababadi
BACKGROUND: Increased systematic pro-inflammatory cytokines is the main cause of the inflammatory conditions of the hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this project, serum levels of IL-29 and whole blood levels of microRNA-185-5p (miR-185-5p) were evaluated in the hospitalized SARS-CoV-2 infected patients. METHODS: This project was performed on the 60 hospitalized SARS-CoV-2 infected patients and 60 healthy controls to evaluate IL-29 and miR185-5p expression levels...
May 5, 2023: Virology Journal
keyword
keyword
35530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.