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https://www.readbyqxmd.com/read/28753407/il-29-enhances-cxcl10-production-in-tnf-%C3%AE-stimulated-human-oral-epithelial-cells
#1
Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki, Takashi Matsuo
Interleukin-29 (IL-29) is a cytokine belonging to the Type III interferon family. It was recently detected in the gingival crevicular fluid of periodontitis patients. However, the role of IL-29 in the pathogenesis of periodontal disease remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We measured CXCL10 production in TR146 cells, which is a human oral epithelial cell line, using an enzyme-linked immunosorbent assay...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28678391/interferon-lambda1-il-29-and-inorganic-polyphosphate-are-novel-regulators-of-neutrophil-driven-thromboinflammation
#2
Akrivi Chrysanthopoulou, Konstantinos Kambas, Dimitrios Stakos, Ioannis Mitroulis, Alexandros Mitsios, Veroniki Vidali, Iliana Angelidou, Magdalena Bochenek, Stella Arelaki, Athanasios Arampatzioglou, Ioanna-Evdokia Galani, Panagiotis Skendros, Elias A Couladouros, Stavros Konstantinides, Evangelos Andreakos, Katrin Schäfer, Konstantinos Ritis
Neutrophils and neutrophil-released meshwork structures termed neutrophil extracellular traps (NETs) are major mediators of thromboinflammation and emerging targets for therapy, yet the mechanisms and pathways that control the role of neutrophils in thromboinflammation remain poorly understood. Here, we explored the role of IFN-λ1/IL-29, a major antiviral cytokine recently shown to suppress the neutrophil migratory capacity, in prothrombotic and proNETotic functions of neutrophils. In an ex vivo human experimental setting of acute ST-segment elevation myocardial infarction (STEMI), we show that IFN-λ1/IL-29 hinders NET release and diminishes the amount of cytoplasmic TF in neutrophils...
September 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28648005/-components-of-human-placental-extract-and-its-protective-effect-to-rat-from-d-galn-induced-acute-liver-injury
#3
H Q Lei, M L Cheng, J Li, P P Zhou, X H Luo, F Yu
Objective: To evaluate the effect of human placental extracts (HPE) on the protection from acute liver injury (ALI) induced by D-GalN and analyze the components of HPE. Methods: (1)Fourty male mice were randomly divided into five groups (Blank, Model, MgIG, HPE and HPE+ MgIG) for the ALI model and treatments.The serum alanine aminotransferase (ALT) and aspartate transaminase (AST) were determined by biochemical assays.Nitric monoxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (T-AOC) in serum and hepatic tissue were detected by assay kits...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28421993/increased-expression-of-interferon-%C3%AE-in-minor-salivary-glands-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-and-its-synergic-effect-with-interferon-%C3%AE-on-salivary-gland-epithelial-cells
#4
You-Jung Ha, Yong Seok Choi, Eun Ha Kang, Jin-Haeng Chung, Seunghee Cha, Yeong Wook Song, Yun Jong Lee
OBJECTIVES: To investigate the expressions of interferon (IFN)-λs and their receptor, IL28RA, in minor salivary glands (MSG) of pSS patients and their effects on the salivary gland cells. METHODS: The expressions of IFN-λs and IL28RA were evaluated in MSG by immunohistochemistry in 15 patients with pSS and in 5 patients with non-SS sicca. Poly(I:C)-induced IL-28A and IL-29 expressions were determined in immortalized human salivary gland acinar (NS-SV-AC) and ductal (NS-SV-DC) cell lines...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28388308/identification-of-type-iii-interferon-ifn-%C3%AE-in-chinese-goose-gene-structure-age-dependent-expression-profile-and-antiviral-immune-characteristics-in-vivo-and-in-vitro
#5
Qin Zhou, Wei Zhang, Shun Chen, Anqi Wang, Lipei Sun, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen, Anchun Cheng
Type III interferons (IFN-λ1/λ2/λ3, also known as IL-29/28A/28B, and IFN-λ4) are a recently discovered interferon group. In this study, we first identified the Chinese goose IFN-λ (goIFN-λ). The full-length sequence of goIFN-λ was found to be 823 bp. There was only one open reading frame that contained 570 bp, and, encoded 189 amino acids. The predicted goIFN-λ protein showed 78%, 67%, and 40% amino acid identity with duIFN-λ, chIFN-λ, and hIFN-λ3, respectively. The tissue distribution of goIFN-λ existed as a parallel distribution with goIFNLR1 as its functional receptor, which was mainly expressed in epithelium-rich tissues, such as lung, gizzard, proventriculus, skin and pancreas, and immune tissues, such as harderian gland and thymus...
June 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28373098/a-comprehensive-evaluation-of-nasal-and-bronchial-cytokines-and-chemokines-following-experimental-rhinovirus-infection-in-allergic-asthma-increased-interferons-ifn-%C3%AE-and-ifn-%C3%AE-and-type-2-inflammation-il-5-and-il-13
#6
Trevor T Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico Del-Rosario, Jaideep Dhariwal, Paul D W Kirk, Michael P H Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M Hunt, Trevor L Hunt, Duncan G Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J Jackson, Sebastian L Johnston
BACKGROUND: Rhinovirus infection is a major cause of asthma exacerbations. OBJECTIVES: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. METHODS: We used nasosorption on days 0, 2-5 and 7 and bronchosorption at baseline and day 4 to sample mucosal lining fluid to investigate airway mucosal responses to rhinovirus infection in patients with allergic asthma (n=28) and healthy non-atopic controls (n=11), by using a synthetic absorptive matrix and measuring levels of 34 cytokines and chemokines using a sensitive multiplex assay...
May 2017: EBioMedicine
https://www.readbyqxmd.com/read/28330867/influenza-vaccines-differentially-regulate-the-interferon-response-in-human-dendritic-cell-subsets
#7
Shruti Athale, Romain Banchereau, LuAnn Thompson-Snipes, Yuanyuan Wang, Karolina Palucka, Virginia Pascual, Jacques Banchereau
Human dendritic cells (DCs) play a fundamental role in the initiation of long-term adaptive immunity during vaccination against influenza. Understanding the early response of human DCs to vaccine exposure is thus essential to determine the nature and magnitude of maturation signals that have been shown to strongly correlate with vaccine effectiveness. In 2009, the H1N1 influenza epidemics fostered the commercialization of the nonadjuvanted monovalent H1N1 California vaccine (MIV-09) to complement the existing nonadjuvanted trivalent Fluzone 2009-2010 vaccine (TIV-09)...
March 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28289419/cytokine-signatures-in-mucocutaneous-and-ocular-beh%C3%A3-et-s-disease
#8
Giuseppe Lopalco, Orso Maria Lucherini, Antonio Lopalco, Vincenzo Venerito, Claudia Fabiani, Bruno Frediani, Mauro Galeazzi, Giovanni Lapadula, Luca Cantarini, Florenzo Iannone
Behçet's disease (BD) is a multi-systemic inflammatory disorder consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis; however, many other organs may be affected. Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. On this basis, the primary aim of our study was to compare a core set of pro-inflammatory cytokines between patients with BD and healthy control (HC)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28238051/il-28-and-il-29-as-protective-markers-in-subject-with-dengue-fever
#9
Chih-Hsing Hung, Chung-Hao Huang, Lin Wang, Chun-Chi Huang, Meng-Chieh Wu, Yi-Ying Chin, Chun-Yu Lin, Ko Chang, Deng-Chyang Wu, Yen-Hsu Chen
About 400 million people every year are estimated to contract dengue virus infection, which causes prolonged morbidity and sometimes mortality. Interleukin (IL)-28 and IL-29 are relatively newly discovered cytokines and play an important role in our immune defense against pathogens, especially for viral infection. In the present study, we investigated serum IL-28 and IL-29 expression and the relationship to clinical and laboratory parameters in patients with dengue virus infection. Adult patients with dengue (n = 45) and control group (n = 24) were included prospectively...
February 25, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28154345/elevated-serum-levels-of-interleukin-29-are-associated-with-disease-activity-in-rheumatoid-arthritis-patients-with-anti-cyclic-citrullinated-peptide-antibodies
#10
Qiong-Jie Chang, Cheng Lv, Feng Zhao, Ting-Shuang Xu, Ping Li
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that may lead to progressive joint destruction. The anti-cyclic citrullinated peptide (anti-CCP) antibody is an essential marker for the diagnosis of RA and has a crucial role in the bone destruction in RA. Recent studies have shown that interleukin (IL)-29, a vital member of type III interferon (IFN) family, could enhance proinflammatory cytokine production and might be involved in the joint destruction in RA. Therefore, in this study, we aimed to examine the role of IL-29 in RA patients with anti-CCP antibodies...
February 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27637354/the-role-of-il-29-in-immunity-and-cancer
#11
REVIEW
Noah E Kelm, Ziwen Zhu, Vivi A Ding, Huaping Xiao, Mark R Wakefield, Qian Bai, Yujiang Fang
Interleukin-29 (IL-29) is a new member of the recently discovered interferon λ (IFNλ) family. It is produced predominantly by maturing dendritic cells and macrophages. It has been implicated in numerous immunological responses and has shown antiviral activity similar to the Type I interferons, although its target cell population is more limited than the Type I interferons. In recent years, the role of IL-29 in the pathogenesis of various cancers has also been extensively studied. In this review, we will discuss the recent advances of IL-29 in immunological processes and the pathogenesis of various cancer...
October 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27622317/raised-interferon-%C3%AE-type-3-interferon-and-interferon-stimulated-genes-evidence-of-innate-immune-activation-in-neutrophilic-asthma
#12
J da Silva, C Hilzendeger, C Moermans, F Schleich, M Henket, T Kebadze, P Mallia, M R Edwards, S L Johnston, R Louis
BACKGROUND: Interferons play an important role in innate immunity. Previous studies report deficiency in virus induction of interferon (IFN)-α, IFN-β and IFN-λ in bronchial epithelial and bronchial lavage cells in atopic asthmatics. It is now recognized that asthma is a heterogeneous disease comprising different inflammatory phenotypes, some of which may involve innate immune activation in the absence of overt infection. OBJECTIVE: The aim of this study was to investigate whether the severity of asthma or a specific cellular sputum pattern may be linked to evidence of innate immune activation...
March 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27617784/increased-serum-levels-of-il-28-and-il-29-and-the-protective-effect-of-il28b-rs8099917-polymorphism-in-patients-with-hashimoto-s-thyroiditis
#13
Dilek Arpaci, Sevim Karakas Celik, Murat Can, Gunes Cakmak Genc, Fatih Kuzu, Mustafa Unal, Taner Bayraktaroglu
Hashimoto's thyroiditis (HT) is thought to result from decreased T helper type 2 (Th2) responses, leading to the progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) are recently described members of the IFN-λ family and have been shown to decrease the production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in HT remain unknown. The purpose of this study was to examine whether IL29 and IL28B gene polymorphisms are susceptibility genes for the development of HT...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27583440/il-28b-genetic-variants-determine-the-extent-of-monocyte-induced-activation-of-nk-cells-in-hepatitis-c
#14
Benjamin Krämer, Claudia Finnemann, Beatriz Sastre, Philipp Lutz, Andreas Glässner, Franziska Wolter, Felix Goeser, Pavlos Kokordelis, Dominik Kaczmarek, Hans-Dieter Nischalke, Christian P Strassburg, Ulrich Spengler, Jacob Nattermann
BACKGROUND: Immuno-genetic studies suggest a functional link between NK cells and λ-IFNs. We recently showed that NK cells are negative for the IFN-λ receptor IFN-λR1 and do not respond to IFN-λ, suggesting a rather indirect association between IL-28B genotype and NK cell activity. METHODS: A total of 75 HCV(+) patients and 67 healthy controls were enrolled into this study. IL-28B (rs12979860) and IFNL-4 (rs368234815) genotypes were determined by rtPCR. Total PBMC, monocytes, and NK cells were stimulated with IL-29, the TLR-7/8 agonist R848, or a combination of both...
2016: PloS One
https://www.readbyqxmd.com/read/27561689/anti-tumor-immunity-elicited-by-direct-intratumoral-administration-of-a-recombinant-adenovirus-expressing-either-il-28a-ifn-%C3%AE-2-or-il-29-ifn-%C3%AE-1
#15
K Hasegawa, M Tagawa, K Takagi, H Tsukamoto, Y Tomioka, T Suzuki, Y Nishioka, T Ohrui, M Numasaki
Interleukin (IL)-28A/interferon (IFN)-λ2 and IL-29/IFN-λ1 have been demonstrated to elicit direct and indirect anti-tumor actions. In this study, we constructed an adenovirus vector expressing either IL-28A/IFN-λ2 (AdIL-28A) or IL-29/IFN-λ1 (AdIL-29) to evaluate the therapeutic properties of intratumoral injection of recombinant adenovirus to apply for the clinical implementation of cancer gene therapy. Despite the lack of an anti-proliferative effect on MCA205 and B16-F10 cells, a retarded growth of established subcutaneous tumors was observed following multiple injections of either AdIL-28A or AdIL-29 when compared with AdNull...
August 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27466422/replication-of-human-norovirus-rna-in-mammalian-cells-reveals-lack-of-interferon-response
#16
Lin Qu, Kosuke Murakami, James R Broughman, Margarita K Lay, Susana Guix, Victoria R Tenge, Robert L Atmar, Mary K Estes
UNLABELLED: Human noroviruses (HuNoVs), named after the prototype strain Norwalk virus (NV), are a leading cause of acute gastroenteritis outbreaks worldwide. Studies on the related murine norovirus (MNV) have demonstrated the importance of an interferon (IFN) response in host control of virus replication, but this remains unclear for HuNoVs. Despite the lack of an efficient cell culture infection system, transfection of stool-isolated NV RNA into mammalian cells leads to viral RNA replication and virus production...
October 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27454079/tlr9-re-expression-in-cancer-cells-extends-the-s-phase-and-stabilizes-p16-ink4a-protein-expression
#17
P Parroche, G Roblot, F Le Calvez-Kelm, I Tout, M Marotel, M Malfroy, G Durand, J McKay, M Ainouze, C Carreira, O Allatif, A Traverse-Glehen, M Mendiola, J J Pozo-Kreilinger, C Caux, M Tommasino, N Goutagny, U A Hasan
Toll-like receptor 9 (TLR9) recognizes bacterial, viral or cell damage-associated DNA, which initiates innate immune responses. We have previously shown that TLR9 expression is downregulated in several viral induced cancers including HPV16-induced cervical neoplasia. Findings supported that downregulation of TLR9 expression is involved in loss of anti-viral innate immunity allowing an efficient viral replication. Here we investigated the role of TLR9 in altering the growth of transformed epithelial cells. Re-introducing TLR9 under the control of an exogenous promoter in cervical or head and neck cancer patient-derived cells reduced cell proliferation, colony formation and prevented independent growth of cells under soft agar...
2016: Oncogenesis
https://www.readbyqxmd.com/read/27433031/interleukin-29-enhances-synovial-inflammation-and-cartilage-degradation-in-osteoarthritis
#18
Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang
We have recently shown that IL-29 was an important proinflammatory cytokine in pathogenesis of rheumatoid arthritis (RA). Inflammation also contributes to the pathogenesis of osteoarthritis (OA). The aim of this study was to investigate the effect and mechanism of IL-29 on cytokine production and cartilage degradation in OA. The mRNA levels of IL-29 and its specific receptor IL-28Ra in peripheral blood mononuclear cells (PBMCs) were significantly increased in OA patients when compared to healthy controls (HC)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27418822/reduced-sputum-expression-of-interferon-stimulated-genes-in-severe-copd
#19
Clarissa Hilzendeger, Jane da Silva, Monique Henket, Florence Schleich, Jean Louis Corhay, Tatiana Kebadze, Michael R Edwards, Patrick Mallia, Sebastian L Johnston, Renaud Louis
BACKGROUND: Exacerbations of COPD are frequent and commonly triggered by respiratory tract infections. The purpose of our study was to investigate innate immunity in stable COPD patients. METHODS: Induced sputum was collected from 51 stable consecutive COPD patients recruited from the COPD Clinic of CHU Liege and 35 healthy subjects. Expression of interferons beta (IFN-β) and lambda1 (IL-29), IFN-stimulated genes (ISGs) MxA, OAS, and viperin were measured in total sputum cells by reverse transcription quantitative polymerase chain reaction (RT-qPCR)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27094154/clinical-and-cytokine-profile-evaluation-in-northeast-brazilian-psoriasis-plaque-type-patients
#20
Pablo Ramon Gualberto Cardoso, Emerson Vasconcelos de Andrade Lima, Mariana Modesto de Andrade Lima, Moacyr Jesus Barreto de Melo Rêgo, Claudia Diniz Lopes Marques, Ivan da Rocha Pitta, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta
Psoriasis is a common, enigmatic, and recurrent disease. The precise etiology and pathogenesis of psoriasis are still unclear. Psoriasis has been treated as an inflammatory disorder related to an underlying Th1/Th17-dominated immune response. Interleukins are involved in the development of psoriasis lesions through Th-17-associated inflammation. Th1 and Th17 cytokines are found in skin lesions and in the peripheral blood of psoriasis patients. We sought to analyze serum levels of IL-1-β, IL-8, IL-9, IL-27, IL-29, IL-35, IFN-γ, TNF and TGF-β in patients with psoriasis and healthy control volunteers...
March 1, 2016: European Cytokine Network
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