keyword
https://read.qxmd.com/read/32468318/interleukin-29-regulates-t-follicular-helper-cells-by-repressing-bcl6-in-rheumatoid-arthritis-patients
#21
JOURNAL ARTICLE
Tingshuang Xu, Tianyi Yan, Ping Li
INTRODUCTION: We aimed to investigate whether Interleukin-29 (IL-29) directly affects T follicular helper (Tfh) cell frequency in rheumatoid arthritis (RA), which are both related to RA-specific antibody responses. METHODS: Here, we explored the effect of IL-29 on Tfh cell production in RA patients using a combination of enzyme-linked immunosorbent assay (ELISA), flow cytometry (FCM), CD4+ T cell culture, western blotting, and reverse transcription-polymerase chain reaction (RT-PCR)...
May 28, 2020: Clinical Rheumatology
https://read.qxmd.com/read/31827765/rhinovirus-species-and-tonsillar-immune-responses
#22
JOURNAL ARTICLE
Emilia Mikola, Oscar Palomares, Riitta Turunen, Matti Waris, Lotta E Ivaska, Antti Silvoniemi, Tuomo Puhakka, Beate Rückert, Tytti Vuorinen, Mübeccel Akdis, Cezmi A Akdis, Tuomas Jartti
BACKGROUND: Rhinovirus A and C infections are important contributors to asthma induction and exacerbations. No data exist on the interaction of local immune responses in rhinovirus infection. Therefore, we aimed to determine the tonsillar immune responses according to rhinovirus A, B and C infections. METHODS: We collected tonsillar samples, nasopharyngeal aspirates and peripheral blood from 42 rhinovirus positive tonsillectomy patients. Fifteen respiratory viruses or their types were investigated from nasopharynx and tonsil tissue, and rhinovirus species were typed...
2019: Clinical and Translational Allergy
https://read.qxmd.com/read/31642723/single-nucleotide-polymorphisms-rs12979860-and-rs8099917-in-il-28b-and-spontaneous-clearance-of-hepatitis-c-genotype-4
#23
JOURNAL ARTICLE
A R Youssef, S S Hamam, R M Elkholy
No abstract text is available yet for this article.
April 2020: British Journal of Biomedical Science
https://read.qxmd.com/read/31551080/correlation-between-interleukin-28-gene-polymorphism-with-interleukin-28-cytokine-levels-and-viral-genotypes-among-hcv-patients-in-yazd-iran
#24
JOURNAL ARTICLE
Mansour Moghimi, Forough Tavakoli, Masoud Doosti, Abbas Ahmadi-Vasmehjani, Mohsen Akhondi-Meybodi
OBJECTIVES: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. RESULT: The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a...
September 24, 2019: BMC Research Notes
https://read.qxmd.com/read/31383827/the-role-of-hepatitis-c-virus-ns5a-region-mutation-and-snp-il-28b-of-host-to-support-successful-pegylated-interferon-and-ribavirin-treatment-in-patients-with-hcv-hiv-coinfection-a-prospective-cohort-study
#25
JOURNAL ARTICLE
Juferdy Kurniawan, Rino A Gani, Samsuridjal Djauzi, Fera Ibrahim, Kuntjoro Harimurti, Nafrialdi Nafrialdi, Suzanna Imannuel
BACKGROUND: HIV infection in HCV-infected patients accelerates disease progression and reduces the success rate of Peg-IFN/RBV treatment. HCV mutation in NS5A-ISDR/PKR-BD region improved the outcome in HCV monoinfection treated with Peg-IFN/RBV. SNP-IL28B polymorphism is predicted to have an effect on HCV quasispecies evolution. However, the role of NS5A mutation and SNP IL-28B in HIV-HCV coinfection is still unclear. The aim of the study is to determine the role of HCV NS5A-ISDR/PKR-BD mutation and SNP IL-28 polymorphism on the successfulness of Peg-IFN/RBV therapy in HCV-HIV coinfection...
April 2019: Acta Medica Indonesiana
https://read.qxmd.com/read/31269695/ns5a-gene-analysis-by-next-generation-sequencing-in-hcv-nosocomial-transmission-clusters-of-hcv-genotype-1b-infected-patients
#26
JOURNAL ARTICLE
Maria Concetta Bellocchi, Marianna Aragri, Luca Carioti, Lavinia Fabeni, Rosaria Maria Pipitone, Giuseppina Brancaccio, Maria Chiara Sorbo, Silvia Barbaliscia, Velia Chiara Di Maio, Fabrizio Bronte, Stefania Grimaudo, Walter Mazzucco, Ferdinando Frigeri, Marco Cantone, Antonio Pinto, Carlo Federico Perno, Antonio Craxì, Giovanni Battista Gaeta, Vito Di Marco, Francesca Ceccherini-Silberstein
Background : The aim of the study was to investigate the intra-host variability through next-generation-sequencing (NGS) of the NS5A-gene in nosocomial transmission-clusters observed in two Italian hospitals among hepatitis C virus (HCV)-genotype-1b infected patients. Methods : HCV-sequencing was performed by Sanger-sequencing (NS3 + NS5A + NS5B) and by NGS (NS5A, MiSeq-Illumina) in 15 HCV-1b infected patients [five acute with onco-hematologic-disease and 10 (4/6 acute/chronic) with β-thalassemia]. Resistance-associated-substitutions (RAS) were analysed by Geno2pheno-algorithm...
July 2, 2019: Cells
https://read.qxmd.com/read/31196204/association-of-polymorphisms-in-inflammatory-cytokines-encoding-genes-with-severe-cases-of-influenza-a-h1n1-and-b-in-an-iranian-population
#27
JOURNAL ARTICLE
Mohsen Keshavarz, Haideh Namdari, Mohammad Farahmand, Parvaneh Mehrbod, Talat Mokhtari-Azad, Farhad Rezaei
BACKGROUND: The increased levels of blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A, influenza B and people with influenza-like illness (ILI). Functional genetic polymorphisms caused by single nucleotide polymorphisms (SNPs) in inflammatory cytokines genes can influence their functions either qualitatively or quantitatively, which is associated with the possibility of severe influenza infections. The aim of the present case-control study was to investigate the association of polymorphisms in inflammatory cytokines genes with influenza patients and ILI group in an Iranian population...
June 13, 2019: Virology Journal
https://read.qxmd.com/read/31121287/interleukin-28-is-a-potential-therapeutic-target-for-sepsis
#28
JOURNAL ARTICLE
Qin Luo, Yi Liu, Shuang Liu, Yibing Yin, Banglao Xu, Ju Cao
Identification of new therapeutic targets for the treatment of sepsis is imperative. We report here that cytokine IL-28 (IFN-λ) levels were elevated in clinical and experimental sepsis. Neutralization of IL-28 protected mice from lethal sepsis induced by cecal ligation and puncture (CLP), which was associated with improved bacterial clearance and enhanced neutrophil infiltration. Conversely, administration of recombinant IL-28 aggravated mortality, facilitated bacterial dissimilation and limited neutrophil recruitment, in the model of sepsis induced by CLP...
May 20, 2019: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/30632069/il28ra-inhibits-human-epidermal-keratinocyte-proliferation-by-inhibiting-cell-cycle-progression
#29
JOURNAL ARTICLE
Xueli Yin, Shengquan Zhang, Bao Li, Yaohua Zhang, Xuejun Zhang
Interleukin (IL) 28 receptor α (IL28RA) is a well-known candidate for psoriasis susceptibility based on previous genome-wide association study (GWAS) analysis. However, the function of IL28RA in psoriasis has not been elucidated. In the present study, the expression of IL28RA was significantly decreased in lesional tissues from patients with plaque psoriasis when compared with the expression observed in adjacent non-lesional tissues. In vitro studies further demonstrated that in the presence of IL-29, HaCaT keratinocytes with IL28RA knockdown exhibited a faster rate of proliferation than control cells, and an enhanced ratio of cells in the S and G2/M phase...
January 10, 2019: Molecular Biology Reports
https://read.qxmd.com/read/30503785/regeneration-after-radiation-and-immune-mediated-tissue-injury-is-not-enhanced-by-type-iii-interferon-signaling
#30
JOURNAL ARTICLE
Julius C Fischer, Chia-Ching Lin, Simon Heidegger, Alexander Wintges, Martin Schlapschy, Matthias Beudert, Stephanie E Combs, Florian Bassermann, Arne Skerra, Tobias Haas, Hendrik Poeck
PURPOSE: Type I interferon (IFN-I) and IL-22 modulate regeneration of the thymus and intestinal epithelial cells (IECs) after cytotoxic stress like irradiation. Radiation-induced damage to thymic tissues and IECs is a crucial aspect during the pathogenesis of inadequate immune reconstitution and acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with myeloablative total body irradiation (TBI), respectively. IL-22 and IFN-I reduce severity of acute GVHD after allo-HSCT with myeloablative TBI...
November 29, 2018: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30478788/factors-related-to-fatalities-and-clinical-progression-of-crimean-congo-hemorrhagic-fever-patients-and-the-effects-of-il-28-b-gene-polymorphism
#31
JOURNAL ARTICLE
Feyza Yıldız Aytekin, Hüseyin Şener Barut, Aydın Rüstemoğlu, Ayfer Atay, Özgür Günal, Fazilet Duygu
Mortality rates of Crimean-Congo hemorrhagic fever (CCHF) vary from 5% to 80%. However, there is no clear information available about why this disease is fatal for some people while others recover. In this study, the factors related to fatalities and serious clinical progression of CCHF patients and the correlation between serious prognosis and IL 28-B gene polymorphism were investigated. The study included 107 patients with a preliminary diagnosis of CCHF, and the patients were found positive for CCHFV RNA based on polymerase chain reaction (PCR) analysis...
November 26, 2018: Archives of Virology
https://read.qxmd.com/read/30234791/the-effectiveness-of-ledipasvir-sofosbuvir-in-youth-with-genotype-4-hepatitis-c-virus-a-single-egyptian-center-study
#32
JOURNAL ARTICLE
Hanan Fouad, Amal Mohamed, Magda Sabry, Hossam Abdel Aziz, Basem Eysa, Mohamed Rabea
BACKGROUND: Licensure of ledipasvir/sofosbuvir for chronic hepatitis C virus (HCV) infection in adolescents, was based upon clinical trials on patients mainly with genotype-1. We aimed to evaluate the effectiveness and short-term safety of this newly approved antiviral in adolescents with HCV genotype-4. METHOD: This was a study of 51 HCV-infected adolescents, who received the adult dose of ledipasvir/sofosbuvir, once daily for 12 weeks, and were followed-up for 12 weeks post-treatment...
September 18, 2018: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/30001863/interleukin-29-inhibits-rankl-induced-osteoclastogenesis-via-activation-of-jnk-and-stat-and-inhibition-of-nf-%C3%AE%C2%BAb-and-nfatc1
#33
JOURNAL ARTICLE
Qiuyue Peng, Aishu Luo, Zihao Zhou, Wenhua Xuan, Ming Qiu, Qin Wu, Lingxiao Xu, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang
Interleukin (IL)-29 is known to modulate immune functions of monocytes or macrophages. In this study, we investigated the effect and its underlying mechanism of IL-29 on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis using murine macrophage cell line RAW264.7 cells and bone-marrow-derived monocyte/macrophage precursor cells (BMMs), and human peripheral blood mononuclear cells (PBMCs). In response to human recombinant IL-29, cell viability and apoptosis were assessed by Cell Counting Kit-8 and flow cytometry; the osteoclast formation and activity by tartrate-resistant acid phosphatase (TRAP) staining and pit formation assay, respectively; the expression and activation of molecules that associated with osteoclastogenesis by real time-PCR, immunoblotting or immunofluorescent analysis...
July 9, 2018: Cytokine
https://read.qxmd.com/read/29942488/tonsillar-cytokine-expression-between-patients-with-tonsillar-hypertrophy-and-recurrent-tonsillitis
#34
JOURNAL ARTICLE
Emilia Mikola, Varpu Elenius, Maria Saarinen, Oscar Palomares, Matti Waris, Riitta Turunen, Tuomo Puhakka, Lotta Ivaska, Beate Rückert, Alar Aab, Tero Vahlberg, Tytti Vuorinen, Tobias Allander, Carlos A Camargo, Mübeccel Akdis, Cezmi A Akdis, Tuomas Jartti
Background: Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis. Methods: Tonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed...
2018: Clinical and Translational Allergy
https://read.qxmd.com/read/29517696/role-of-il-28b-genetic-variants-in-hcv-related-liver-disease-severity-in-patients-with-different-viral-genotypes
#35
JOURNAL ARTICLE
Ching-I Huang, Chung-Feng Huang, Ming-Lun Yeh, Yi-Hung Lin, Po-Cheng Liang, Shang-Yin Vanson Liu, Meng-Hsuan Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Wan-Long Chuang, Chia-Yen Dai, Ming-Lung Yu
Reports of the role of host interleukin 28B (IL-28B) genetic variants in liver disease severity in patients with chronic hepatitis C (CHC) have obtained conflicting results. The impact of IL-28B in Asian patients with different viral genotypes remains elusive.We try to elucidate the effect of IL-28B genetic variants in a large Asian cohort with different viral genotypes.The association between the IL-28B rs8099917 genotype and liver fibrosis was investigated in 1288 patients with biopsy-proven CHC.Patients with hepatitis C virus genotype 1 (HCV-1) infection comprised 59...
March 2018: Medicine (Baltimore)
https://read.qxmd.com/read/29405153/effect-of-interleukin-28b-polymorphism-on-interleukin-28-expression-and-immunological-recovery-amongst-hiv-1-infected-individuals-following-antiretroviral-therapy
#36
JOURNAL ARTICLE
B V Srinidhi, G John Fletcher, Jaiprasath Sachidanantham, Priscilla Rupali, Veena Vadhini Ramalingam, J P Demosthenes, O C Abraham, Susanne A Pulimood, Grace Rebekah, Rajesh Kannangai
PURPOSE: Type III interferon is well known to have diverse antiviral and immunomodulatory activities. Studies describing the association of interleukin (IL)-28 polymorphisms in treatment-experienced HIV participants are limited. This study was aimed to determine the association of IL-28B gene polymorphisms with immunological recovery in HIV patients on 6-9 months of antiretroviral therapy (ART). METHODS: Eighty treatment-naive HIV patients were recruited, of which 48 patients were followed up after 6-9 months of ART...
October 2017: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/29302255/species-specific-antiviral-activity-of-porcine-interferon-%C3%AE-8-ifn%C3%AE-8
#37
JOURNAL ARTICLE
Eunhye Kim, Hyunjhung Jhun, Joohee Kim, Unjoo Park, Seunghyun Jo, Areum Kwak, Sinae Kim, Tam T Nguyen, Yongsun Kang, Insoo Choi, Joongbok Lee, Heijun Kim, Younghyun Kim, Siyoung Lee, Soohyun Kim
Interferons (IFNs) have been known as antiviral genes and they are classified by type 1, type 2, and type 3 IFN. The type 1 IFN consists of IFNα, IFNβ, IFNτ, and IFNω whereas the type 2 IFN consists of only IFNγ, which is a key cytokine driving T helper cell type 1 immunity. IFNλ belongs to the type 3 IFN, which is also known as IL-28 and IL-29 possessing antiviral activities. Type 1 IFN is produced by viral infection whereas type 2 IFN is induced by mitogenic or antigenic T-cell stimuli. The IFNτ of bovine was first discovered in an ungulate ruminant recognition hormone...
December 2017: Immune Network
https://read.qxmd.com/read/29191501/immunoprecipitation-high-performance-liquid-chromatographic-analysis-of-healing-process-in-chronic-suppurative-osteomyelitis-of-the-jaw
#38
JOURNAL ARTICLE
Soung Min Kim, Mi Young Eo, Yun Ju Cho, Yeon Sook Kim, Suk Keun Lee
PURPOSE: Chronic suppurative osteomyelitis (CSO) of the jaw is one of the most difficult infectious diseases to manage, because it causes progressive bony destruction and is associated with bacterial inhabitation of the sequestra. A combination of antibiotic therapy and surgical debridement is often used to treat CSO. Nevertheless, various systemic conditions can lead to life-threatening complications. METHODS: The present study aimed to explore the wound healing progress in 16 cases of CSO through protein expression analysis of postoperative exudates (POE) that were collected 6 h, 1 day, and 2 days after saucerization and/or decortication...
January 2018: Journal of Cranio-maxillo-facial Surgery
https://read.qxmd.com/read/28894041/analysis-of-the-relationship-between-single-nucleotide-polymorphism-of-the-cd209-il-10-il-28-and-ccr5-d32-genes-with-the-human-predisposition-to-developing-tick-borne-encephalitis
#39
JOURNAL ARTICLE
Piotr Czupryna, Miłosz Parczewski, Sambor Grygorczuk, Sławomir Pancewicz, Joanna Zajkowska, Justyna Dunaj, Maciej Kondrusik, Katarzyna Krawczuk, Anna Moniuszko-Malinowska
<b>Introduction: </b>It is known that in the pathogenesis of tick-borne encephalitis (TBE) various molecules play a significant role. The most prominent factors include IL-10, IL-28B, CD-209 and CCR5. It is reasonable to search for genetic predispositions to the development of various clinical forms of TBE related to the genetic variation of IL-10, IL-28B, CD-209 and CCR5. In this study we aimed to search for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Δ 32) with the human predisposition to development of various clinical presentations of TBE...
January 4, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://read.qxmd.com/read/28647850/wound-healing-protein-profiles-in-the-postoperative-exudate-of-bisphosphonate-related-osteonecrosis-of-mandible
#40
JOURNAL ARTICLE
Soung Min Kim, Mi Young Eo, Yun Ju Cho, Yeon Sook Kim, Suk Keun Lee
Recurrent bacterial infections in cases of bisphosphonate-related osteonecrosis of jaw (BRONJ) frequently occur. Therefore, BRONJ are usually treated by radical saucerization followed by intensive antibiotic medications without bisphosphonate therapy. The postoperative exudate (POE) from BRONJ lesions may directly indicate the inflammatory status of osteomyelitis in patients, but so far, the POE has rarely been examined for its expression of various cytokines and wound healing proteins. A total of 27 cases of BRONJ, which involved the mandible, were selected and their individual POE collected 6 h, 1 day, and 2 days after surgical intervention was analyzed by immunoprecipitation high performance liquid chromatography (IP-HPLC)...
September 2017: European Archives of Oto-rhino-laryngology
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