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IL-28

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https://www.readbyqxmd.com/read/27622317/raised-interferon-%C3%AE-type-3-interferon-and-interferon-stimulated-genes-evidence-of-innate-immune-activation-in-neutrophilic-asthma
#1
J da Silva, C Hilzendeger, C Moermans, F Schleich, M Henket, T Kebadze, P Mallia, M R Edwards, S L Johnston, R Louis
BACKGROUND: Interferons play an important role in innate immunity. Previous studies report deficiency in virus induction of interferon (IFN)-α, IFN-β and IFN-λ in bronchial epithelial and bronchial lavage cells in atopic asthmatics. It is now recognized that asthma is a heterogeneous disease comprising different inflammatory phenotypes, some of which may involve innate immune activation in the absence of overt infection. OBJECTIVE: The aim of this study was to investigate whether the severity of asthma or a specific cellular sputum pattern may be linked to evidence of innate immune activation...
September 13, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27617784/increased-serum-levels-of-il-28-and-il-29-and-the-protective-effect-of-il28b-rs8099917-polymorphism-in-patients-with-hashimoto-s-thyroiditis
#2
Dilek Arpaci, Sevim Karakas Celik, Murat Can, Gunes Cakmak Genc, Fatih Kuzu, Mustafa Unal, Taner Bayraktaroglu
Hashimoto's thyroiditis (HT) is thought to result from decreased T helper type 2 (Th2) responses, leading to the progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) are recently described members of the IFN-λ family and have been shown to decrease the production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in HT remain unknown. The purpose of this study was to examine whether IL29 and IL28B gene polymorphisms are susceptibility genes for the development of HT...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27155288/seasonal-influenza-a-h3n2-virus-infection-and-il-1%C3%AE-il-10-il-17-and-il-28-polymorphisms-in-iranian-population
#3
Lawal Dahiru Rogo, Farhad Rezaei, Seyed Mahdi Marashi, Mir Saeed Yekaninejad, Maryam Naseri, Nastaran Ghavami, Talat Mokhtari-Azad
Increased blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A/H3N2 virus infection. The study was aimed to investigate the polymorphisms of IL-1β, IL-10, IL-17 and IL-28 genes to find the possibility of their association with the clinical outcome of influenza A/H3N2 virus infection among the infected patients in Iran. This is a Case-Control study in which influenza A/H3N2 virus positive confirmed with real time PCR were the cases. DNA samples from groups were genotyped for polymorphisms in rs16944 (IL-1β), rs1800872 (IL-10), rs2275913 (IL-17) and rs8099917 (IL-28)...
May 7, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/26861017/lambda-interferon-restructures-the-nasal-microbiome-and-increases-susceptibility-to-staphylococcus-aureus-superinfection
#4
Paul J Planet, Dane Parker, Taylor S Cohen, Hannah Smith, Justinne D Leon, Chanelle Ryan, Tobin J Hammer, Noah Fierer, Emily I Chen, Alice S Prince
UNLABELLED: Much of the morbidity and mortality associated with influenza virus respiratory infection is due to bacterial coinfection with pathogens that colonize the upper respiratory tract such as methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae. A major component of the immune response to influenza virus is the production of type I and III interferons. Here we show that the immune response to infection with influenza virus causes an increase and restructuring of the upper respiratory microbiota in wild-type (WT) mice but not in Il28r(-/-) mutant mice lacking the receptor for type III interferon...
2016: MBio
https://www.readbyqxmd.com/read/26387177/-effects-of-total-flavonoids-of-propolis-on-apoptosis-of-myocardial-cells-of-chronic-heart-failure-and-its-possible-mechanism-in-rats
#5
Hai-hua Wang, Jin Zeng, Hai-zhen Wang, Yu-xin Jiang, Jing Wang, Ping-ping Zhou
OBJECTIVE: To investigate the effects of total flavonoids of propolis (TFP) on apoptosis of myocardial cells of chronic heart failure and its possible mechanism in rats. METHODS: Six male SD rats were randomly selected as normal control group, the remaining rats were made as chronic heart failure (CHF) model by intraperitoneal injection of adriamycin. The rats in the successful model were randomly divided into five groups (n = 6): CHF group, total flavonoids of propolis low dose group (LD group), total flavonoids of propolis middle dose group (MD group), total flavonoids of propolis high dose group (HD group), digoxin group (DIG group)...
May 2015: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/26386320/combination-therapy-with-inolimomab-and-etanercept-for-severe-steroid-refractory-acute-graft-versus-host-disease
#6
Lenneke F J van Groningen, Aleida M Liefferink, Anton F J de Haan, Nicolaas P M Schaap, J Peter Donnelly, Nicole M A Blijlevens, Walter J F M van der Velden
Steroid-refractory acute graft-versus-host disease (aGVHD) remains an important cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). A protocol on the management of aGVHD was introduced in our center that incorporated a prospective study on combination therapy with inolimomab (anti-IL-2Rα) and etanercept (anti-tumor necrosis factor-α) for steroid-refractory aGVHD. We evaluated the efficacy and safety in 21 consecutively treated patients. The patients had developed refractory aGVHD after SCT (n = 16) or donor lymphocyte infusion (n = 5), and aGVHD was classified as severe in all patients, mostly due to gastrointestinal involvement stages 2 to 4...
January 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26385753/biologic-associated-infections-in-pediatric-rheumatology
#7
REVIEW
Gerd Horneff
During the past 15 years, biologics for juvenile idiopathic arthritis (JIA) therapy has led to new options. However, despite the high effectiveness and safety profile of these agents, infections are of great concern. The risk for bacterial infections, which appears to be increased in JIA patients as a result of the disease itself, seems to be increased further by antirheumatic treatment. Combining data from several sources, infection rates appear to be comparable for abatacept (1.33/100 person-years (PY); 95 % confidence interval (CI) = 0...
November 2015: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26384383/mesenteric-fat-lipolysis-mediates-obesity-associated-hepatic-steatosis-and-insulin-resistance
#8
Stephan Wueest, Flurin Item, Fabrizio C Lucchini, Tenagne D Challa, Werner Müller, Matthias Blüher, Daniel Konrad
Hepatic steatosis and insulin resistance are among the most prevalent metabolic disorders and are tightly associated with obesity and type 2 diabetes. However, the underlying mechanisms linking obesity to hepatic lipid accumulation and insulin resistance are incompletely understood. Glycoprotein 130 (gp130) is the common signal transducer of all interleukin 6 (IL-6) cytokines. We provide evidence that gp130-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin resistance. In obese mice, adipocyte-specific gp130 deletion reduced basal lipolysis and enhanced insulin's ability to suppress lipolysis from mesenteric but not epididymal adipocytes...
January 2016: Diabetes
https://www.readbyqxmd.com/read/26382922/relationship-of-ykl-40-and-adiponectin-and-subclinical-atherosclerosis-in-asymptomatic-patients-with-type-1-diabetes-mellitus-from-a-european-mediterranean-population
#9
Eva Aguilera, Enric Serra-Planas, M Luisa Granada, Silvia Pellitero, Jordi L Reverter, Núria Alonso, Berta Soldevila, Dídac Mauricio, Manel Puig-Domingo
BACKGROUND: The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations of both markers have been reported in patients with type 1 diabetes (T1D). AIM: To assess the possible role of YKL-40 and adiponectin as a marker of subclinical cardiovascular disease in asymptomatic patients with type 1 diabetes with no history of ischemic or macrovascular heart disease and its relationship with other classic inflammatory biomarkers...
September 18, 2015: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26382031/dexamethasone-induces-apoptosis-in-pulmonary-arterial-smooth-muscle-cells
#10
Laura C Price, Dongmin Shao, Chao Meng, Frederic Perros, Benjamin E Garfield, Jie Zhu, David Montani, Peter Dorfmuller, Marc Humbert, Ian M Adcock, Stephen J Wort
BACKGROUND: Dexamethasone suppressed inflammation and haemodynamic changes in an animal model of pulmonary arterial hypertension (PAH). A major target for dexamethasone actions is NF-κB, which is activated in pulmonary vascular cells and perivascular inflammatory cells in PAH. Reverse remodelling is an important concept in PAH disease therapy, and further to its anti-proliferative effects, we sought to explore whether dexamethasone augments pulmonary arterial smooth muscle cell (PASMC) apoptosis...
September 18, 2015: Respiratory Research
https://www.readbyqxmd.com/read/26381232/immunity-and-clinical-efficacy-of-an-inactivated-enterovirus-71-vaccine-in-healthy-chinese-children-a-report-of-further-observations
#11
RANDOMIZED CONTROLLED TRIAL
Longding Liu, Zhaojun Mo, Zhenglun Liang, Ying Zhang, Rongcheng Li, Kien Chai Ong, Kum Thong Wong, Erxia Yang, Yanchun Che, Jingjing Wang, Chenghong Dong, Min Feng, Jing Pu, Lichun Wang, Yun Liao, Li Jiang, Soon Hao Tan, Perera David, Teng Huang, Zhenxin Zhou, Xuanyi Wang, Jielai Xia, Lei Guo, Ling Wang, Zhongping Xie, Wei Cui, Qunying Mao, Yan Liang, Hongling Zhao, Ruixiong Na, Pingfang Cui, Haijing Shi, Junzhi Wang, Qihan Li
BACKGROUND: To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy. METHODS: A sub-cohort of 1,100 volunteers from Guangxi Province in China was eligible for enrolment and randomly administered either the EV71 vaccine or a placebo on days 0 and 28 in a phase III clinical trial and then observed for the following 2 years with approval by an independent ethics committee of Guangxi Zhuang Autonomous Region, China...
2015: BMC Medicine
https://www.readbyqxmd.com/read/26380815/association-between-pro-il-8-and-anti-inflammatory-il-10-cytokine-variants-and-their-serum-levels-and-h-pylori-related-gastric-carcinogenesis-in-northern-india
#12
Sushil Kumar, Niraj Kumari, Rama Devi Mittal, Samir Mohindra, Uday C Ghoshal
BACKGROUND: Interleukin (IL)-8 -251 T/A and IL-10 (-1082 G/A and -819/592 C/T) polymorphisms and their expression may influence gastritis, atrophy, intestinal metaplasia (IM) and gastric cancer (GC) following H. pylori infection. METHODS: Genotyping of these genes was performed (ASO-PCR) in 200, 182 and 250 with GC, functional dyspepsia (FD) and healthy controls (HC), respectively. Anti-H. pylori IgG-antibody was tested in all and serums IL-8 and IL-10 were measured randomly in 60 subjects of each group by ELISA...
December 2015: Meta Gene
https://www.readbyqxmd.com/read/26380557/impaired-spatial-learning-memory-after-isoflurane-anesthesia-or-appendectomy-in-aged-mice-is-associated-with-microglia-activation
#13
Hui-Lin Wang, Rui-Hua Ma, Hao Fang, Zhang-Gang Xue, Qing-Wu Liao
Postoperative cognitive dysfunction (POCD) has been one of the most common problems in elderly patients following surgery. But the specific mechanism of POCD is still not clear. To further understand the reason of these postoperative behavioral deficits, we evaluated the spatial learning memory of both adult (3 months) and aged (18 months) male mice, 3 or 28 days after isoflurane (Iso) exposure for two hours or appendectomy (App). Hippocampal microglia activation and IL-1β, TNF-α, and IFN-γ expression were also evaluated at day 3, day 14 and day 28 after Iso exposure or appendectomy...
2015: Journal of Cell Death
https://www.readbyqxmd.com/read/26379954/effects-of-dexmedetomidine-on-anesthesia-recovery-period-and-postoperative-cognitive-function-of-patients-after-robot-assisted-laparoscopic-radical-cystectomy
#14
Lingling Ding, Hong Zhang, Weidong Mi, Tao Wang, Yan He, Xu Zhang, Xin Ma, Hongzhao Li
OBJECTIVE: The purpose of the study was to evaluate the neuroprotective effect of dexmedetomidine on anesthesia recovery period and postoperative cognitive function of patients after robot-assisted laparoscopic radical cystectomy and ileal conduit diversion. METHODS: A total of 40 elective patients who would undergo robot-assisted laparoscopic radical cystectomy and ileal conduit diversion. They were randomly divided into two groups in a double-blind manner. After pneumoperitoneum established, all patients adopted 40° trendelenberg position...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26379842/prognostic-significance-of-interleukin-17-in-solid-tumors-a-meta-analysis
#15
Yunhui Zeng, Qiongwen Zhang, Hong Wang, Minxun Lu, Hongyu Kong, Yingyi Zhang, Huashan Shi
BACKGROUND: The prognostic significance of intratumoral and peripheral interleukin-17 (IL-17) in tumors has been studied worldwide during these years, providing un-uniformed conclusions. METHODS: We conducted a meta-analysis of published literatures that evaluated the correlation between IL-17 and clinical staging, overall survival (OS) and/or disease free survival (DFS). RESULTS: A total of 28 studies enrolling 2902 patients were included...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26375113/sep-11-anti-ros-treatment-by-specific-mitochondria-targeted-antioxidants-skq1-and-mitotempo-exacerbate-mortality-in-the-acute-murine-polymicrobial-sepsis
#16
P Rademann, A Weidinger, S Drechsler, A Klotz, M Jafarmadar, J Zipperle, A Hacobian, S Dumitrescu, S Bahrami, A Kozlov, M F Osuchowski
INTRODUCTION: Altered mitochondrial function by excessive production of reactive oxygen species (ROS) has been considered an important factor in pathogenesis of organ failure in sepsis. METHODS: We investigated effects of two specific mitochondria-targeted antioxidants (SkQ1: lipophilic; MitoTEMPO: hydrophilic) on outcome, inflammatory response and organ homeostasis in a mouse model of cecal ligation and puncture (CLP) sepsis. 3-month old female CD-1 mice (n=90) were subjected to moderate-severity CLP, and treated intraperitoneally with SkQ1 (5nmol/kg), MitoTEMPO (50nmol/kg) or saline at 1 h, 12 h, 24 h, 36 h, 48 h post-CLP...
October 2015: Shock
https://www.readbyqxmd.com/read/26375064/hem-2-beneficial-therapeutic-effect-of-an-apoptotic-peripheral-blood-mononuclear-cells-secretome-aposec-supplemented-resuscitation-after-hemorrhagic-traumatic-shock-in-rats
#17
C Penzenstadler, M Ashmwe, A Klotz, M Jafarmadar, M M Kasiri, H J Ankersmit, H Redl, S Bahrami
INTRODUCTION: Hemorrhagic traumatic shock (HTS) and reperfusion is often associated with general inflammatory response and organ dysfunction. Recent preclinical studies have shown that APOSEC exerts cytoprotective and/or immunomodulating effects. We evaluated the therapeutic potential of APOSEC in a HTS model in rats. METHODS: Rats were subjected to HTS (MAP 30-35 mmHg until decompensation) and a resuscitation protocol that includes a prehospital restrictive reperfusion (30 ml/kg/h, MAP maintained at 50-55 mmHg for 40 min) followed by an adequate reperfusion phase (75 ml/kg/h over 60 min, MAP to baseline)...
October 2015: Shock
https://www.readbyqxmd.com/read/26374116/the-food-supplement-coenzyme-q10-and-suppression-of-antitubercular-drug-induced-hepatic-injury-in-rats-the-role-of-antioxidant-defence-system-anti-inflammatory-cytokine-il-10
#18
Udhaya Lavinya Baskaran, Evan Prince Sabina
INTRODUCTION: Isoniazid (INH) and rifampicin (RIF), the most common anti-tubercular therapy, causes hepatotoxicity through a multi-step mechanism in certain individuals. The present study was an attempt to evaluate the hepatoprotective effect of coenzyme Q10 against INH + RIF-induced hepatotoxicity in Wistar albino rats. METHODS: Hepatotoxicity was induced by the oral administration of INH + RIF (50 mg/kg b.w. each/day) in normal saline water for 28 days...
October 2015: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/26373328/fattori-professionali-alla-base-di-alterazioni-dell-umore-e-dell-ansia-tra-i-giovani-medici
#19
Richard Pougnet, Laurence Pougnet, Margaux Kerrien, David Jousset, Brice Loddé, Jean-Dominique Dewitte, Ronan Garlantézec
«Fattori professionali alla base di alterazioni dell'umore e dell'ansia tra i giovani medici». I giovani medici sono esposti a molteplici rischi occupazionali. Scopo del presente studio è valutare i fattori di rischio e i fattori protettivi per i disturbi depressivi e di ansia tra i giovani medici. Materiali e metodi: Tra l'ottobre 2011 e il giugno 2012 abbiamo condotto uno studio trasversale mediante un questionario anonimo online. Sono stati considerati tutti i giovani medici della nostra facoltà. Il questionario verteva su informazioni relative a dati demografici e di salute...
November 2015: La Medicina del Lavoro
https://www.readbyqxmd.com/read/26373327/test-antidroga-su-campioni-di-urina-nei-luoghi-di-lavoro-evidenze-per-migliorare-l-efficacia-di-un-programma-di-screening-di-primo-livello
#20
Valeria Crespi, Ramòna Consuèlo Maio, Giovanni Veronesi, Francesco Gianfagna, Stefano Taborelli, Marco Mario Ferrario
UNLABELLED: Introduzione: Le analisi tossicologiche di primo livello su campioni di urina hanno mostrato una scarsa performance nell'individuare lavoratori che utilizzano sostanze d'abuso. In questo studio sono stati valutati: (i) la prevalenza della positività alle sostanze d'abuso prima e dopo normalizzazione per creatinina urinaria media; (ii) i fattori associati al riscontro di campioni positivi o diluiti (creatinina ≤20 mg/dL). Metodi: I campioni di urina dei lavoratori sono stati raccolti tra il 2008 e il 2012 sul luogo di lavoro o nel nostro laboratorio accreditato...
November 2015: La Medicina del Lavoro
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