Xander Bertels, Ahmed Edris, Judith Garcia-Aymerich, Rosa Faner, Howraman Meteran, Torben Sigsgaard, Peter Alter, Claus Vogelmeier, Nuria Olvera, Nazanin Zounemat Kermani, Alvar Agusti, Gavin C Donaldson, Jadwiga A Wedzicha, Guy G Brusselle, Helena Backman, Eva Rönmark, Anne Lindberg, Judith M Vonk, Kian Fan Chung, Ian M Adcock, Maarten van den Berge, Lies Lahousse
BACKGROUND: The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts. METHODS: This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1 /FVC <0.7 in population-based and clinic-based cohorts, respectively. Clinical characteristics and comorbidities of AO were compared with asthma without airflow obstruction (asthma-only) and chronic obstructive pulmonary disease (COPD) without asthma history (COPD-only)...
August 2023: BMJ Open Respiratory Research