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eosinophil oesophagitis

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https://www.readbyqxmd.com/read/28877359/food-elimination-diets-are-effective-for-long-term-treatment-of-adults-with-eosinophilic-oesophagitis
#1
C C Reed, C Fan, N T Koutlas, N J Shaheen, E S Dellon
BACKGROUND: Limited data describe the long-term efficacy of dietary elimination in eosinophilic oesophagitis (EoE). AIM: To assess the long-term outcomes of food elimination diets for treatment of adults with EoE. METHODS: We conducted a retrospective cohort study at our centre analysing all EoE patients receiving a food elimination diet without concomitant steroids. Baseline data were abstracted using standardised collection forms. Follow-up data from a mean 24...
September 6, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28851715/oesophageal-mastocytosis-eosinophilic-oesophagitis-without-eosinophils
#2
Donevan Westerveld, Jian Li, Sarah Glover
A 59-year-old male with a history of lifelong asthma, allergic rhinitis and hypercholesterolaemia presented to the emergency department for management of severe substernal chest pain with radiating pain to his left arm, nausea and diaphoresis. Physical examination was unrevealing and a cardiac workup including cardiac enzymes, ECG, chest radiographs were negative for an underlying ischaemic event. A subsequent gastrointestinal workup including oesophageal manometry and oesophagogastroduodenoscopy revealed elevated lower oesophageal pressures and histopathology suggestive of mast cell proliferation, respectively...
August 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28776738/editorial-oesophageal-dilation-in-eosinophilic-oesophagitis-can-and-should-but-when-and-how-authors-reply
#3
EDITORIAL
F J Moawad, A J Lucendo, J Molina-Infante
No abstract text is available yet for this article.
September 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28776736/editorial-oesophageal-dilation-in-eosinophilic-oesophagitis-can-and-should-but-when-and-how
#4
EDITORIAL
L Kia, I Hirano
No abstract text is available yet for this article.
September 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28761563/the-emerging-role-of-the-eosinophil-and-its-measurement-in-chronic-cough
#5
REVIEW
Mahboobeh H Sadeghi, Alyn H Morice
Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28639700/systematic-review-health-related-quality-of-life-in-children-and-adults-with-eosinophilic-oesophagitis-instruments-for-measurement-and-determinant-factors
#6
REVIEW
A J Lucendo, L Arias-González, J Molina-Infante, Á Arias
BACKGROUND: Several measures have been used to assess the health-related quality of life (HRQoL) of patients with eosinophilic oesophagitis (EoE). AIMS: To systematically review these HRQoL measures, to appraise measurement properties of specific instruments and to evaluate determinant factors influencing HRQoL in paediatric and adult EoE patients. METHODS: We searched the PubMed, Embase, Scopus, Web of Science (WOS) and PsycINFO databases for documents providing original information on the development of measurement tools and/or evaluation of HRQoL outcomes in EoE patients of all ages...
August 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28628545/salbutamol-therapy-for-food-impaction-in-eosinophilic-oesophagitis
#7
Jorge Amil Dias, Sofia Fernandes, Susana Corujeira, Eunice Trindade, Marta Tavares, Simon Murch
No abstract text is available yet for this article.
June 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28614019/eosinophilic-oesophagitis-an-otolaryngologist-s-perspective
#8
REVIEW
T Gnanasekaran, S Gnanasekaran, J M Wood, P Friedland
Eosinophilic oesophagitis is a diagnosis that is being made more frequently in the assessment of dysphagia in both adults and children. It is unclear whether this is a result of increased prevalence or improved diagnostic methods. Children present commonly to paediatric institutions with foreign body impaction. Research indicates that food impaction may predispose to eosinophilic oesophagitis. This article presents eosinophilic oesophagitis from an otolaryngologist's point of view. It details the clinical features present in the disease as well as how it is diagnosed and managed...
June 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28572918/multi-morbidities-of-allergic-rhinitis-in-adults-european-academy-of-allergy-and-clinical-immunology-task-force-report
#9
REVIEW
C Cingi, P Gevaert, R Mösges, C Rondon, V Hox, M Rudenko, N B Muluk, G Scadding, F Manole, C Hupin, W J Fokkens, C Akdis, C Bachert, P Demoly, J Mullol, A Muraro, N Papadopoulos, R Pawankar, P Rombaux, E Toskala, L Kalogjera, E Prokopakis, P W Hellings, J Bousquet
This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28547386/dupilumab-first-global-approval
#10
REVIEW
Matt Shirley
Dupilumab (Dupixent(®)) is a fully human monoclonal antibody directed against the interleukin (IL)-4 receptor α (IL-4Rα) subunit. Dupilumab inhibits the signalling of the type 2 cytokines IL-4 and IL-13 and was co-developed by Regeneron Pharmaceuticals and Sanofi as a potential therapeutic agent for the treatment of atopic or allergic diseases. In March 2017 dupilumab received its first global approval, in the USA, for use in the treatment of adult patients with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable...
July 2017: Drugs
https://www.readbyqxmd.com/read/28536485/management-of-refractory-eosinophilic-oesophagitis
#11
REVIEW
Evan S Dellon
The goal of this Review is to discuss the clinical approach to patients who do not respond to treatment for eosinophilic oesophagitis (EoE). Refractory EoE is challenging to manage as there are limited data to guide decision-making. In this Review, refractory EoE is defined as persistent eosinophilia in the setting of incomplete resolution of the primary presenting symptoms and incomplete resolution of endoscopic findings following a PPI trial, and after treatment with either topical steroids or dietary elimination...
August 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513085/systematic-review-with-meta-analysis-endoscopic-dilation-is-highly-effective-and-safe-in-children-and-adults-with-eosinophilic-oesophagitis
#12
REVIEW
F J Moawad, J Molina-Infante, A J Lucendo, S E Cantrell, L Tmanova, K M Douglas
BACKGROUND: Oesophageal dilation is frequently used as an adjunct treatment to alleviate symptoms that develop from fibrostenotic remodelling in eosinophilic oesophagitis (EoE). Earlier reports described an increased risk of complications associated with dilation. AIM: Perform a systematic review and meta-analysis to assess the efficacy and safety of endoscopic dilation in children and adults with EoE. METHODS: Professional librarians searched MEDLINE, EMBASE, the Cochrane library, Scopus, and Web of Science for articles in any language describing studies of dilation in EoE through December 2016...
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28502417/analysis-of-bronchial-biopsies-in-chronic-cough
#13
Patricia Macedo, Qingling Zhang, Junpei Saito, Zhike Liang, Lorrette Ffolkes, Andrew G Nicholson, Kian Fan Chung
BACKGROUND: Chronic cough is commonly associated with asthma, gastro-oesophageal reflux disease and postnasal drip, but in a significant proportion, no associated cause can be found. We determined whether examination of bronchial biopsies would be useful in determining the cause associated with chronic cough. METHODS: 100 consecutive patients referred to a specialist cough clinic underwent a systematic assessment including a fiberoptic bronchoscopy for bronchial biopsies...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28470372/food-allergy-in-south-africa
#14
REVIEW
Claudia L Gray
PURPOSE OF THE REVIEW: Whilst food allergy seems to have increased significantly in many developed countries in the past few decades, quality data on the burden of food allergy in many developing countries is scanty. Until recently, South Africa had a dearth of robustly designed food allergy studies. This article summarizes some of the recent research and observations regarding food allergy from the South African setting. RECENT FINDINGS: South Africa has recently seen two important food allergy prevalence studies in selected and unselected populations...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28404554/oesophageal-eosinophilia-in-children-with-coeliac-disease
#15
Anne Ari, Sara Morgenstern, Gabriel Chodick, Manar Matar, Ari Silbermintz, Amit Assa, Yael Mozer-Glassberg, Firas Rinawi, Vered Nachmias-Friedler, Raanan Shamir, Noam Zevit
OBJECTIVES: An association between coeliac disease (CD) and eosinophilic oesophagitis (EoE)/oesophageal eosinophilia (EE) has been suggested. We sought to characterise children with CD+EE in-depth and assess the contribution of each condition to the clinical presentation and treatment response. STUDY DESIGN: Medical records of children with both CD+EE, or isolated EoE diagnosed between 2000 and 2014, were retrospectively reviewed and compared with patients with isolated CD or epigastric pain...
April 12, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28370355/a-visual-analogue-scale-and-a-likert-scale-are-simple-and-responsive-tools-for-assessing-dysphagia-in-eosinophilic-oesophagitis
#16
C C Reed, W A Wolf, C C Cotton, E S Dellon
BACKGROUND: While symptom scores have been developed to evaluate dysphagia in eosinophilic oesophagitis (EoE), their complexity may limit clinical use. AIM: To evaluate a visual analogue scale (VAS) and a 10-point Likert scale (LS) for assessment of dysphagia severity before and after EoE treatment. METHODS: We conducted a prospective cohort study enrolling consecutive adults undergoing out-patient endoscopy. Incident cases of EoE were diagnosed per consensus guidelines...
June 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28339136/eosinophilic-esophagitis-phenotypes-ready-for-prime-time
#17
REVIEW
Dan Atkins, Glenn T Furuta, Chris A Liacouras, Jonathan M Spergel
Eosinophilic esophagitis (EoE) is one of the most common causes of reflux-like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1:2500. Therapeutic options include diet, use of swallowed corticosteroids, or dilation. In the last several years, recent clinical and translational researches have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggest that various phenotypes may also exist in patients with EoE...
June 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28326578/editorial-elemental-diets-for-eosinophilic-oesophagitis
#18
EDITORIAL
D A Katzka
No abstract text is available yet for this article.
April 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28326569/the-dynamics-of-the-oesophageal-squamous-epithelium-normalisation-process-in-patients-with-gastro-oesophageal-reflux-disease-treated-with-long-term-acid-suppression-or-anti-reflux-surgery
#19
RANDOMIZED CONTROLLED TRIAL
L Mastracci, R Fiocca, C Engström, S Attwood, C Ell, J P Galmiche, J G Hatlebakk, G Långström, S Eklund, T Lind, L Lundell
BACKGROUND: Proton pump inhibitors and laparoscopic anti-reflux surgery (LARS) offer long-term symptom control to patients with gastro-oesophageal reflux disease (GERD). AIM: To evaluate the process of 'normalisation' of the squamous epithelium morphology of the distal oesophagus on these therapies. METHODS: In the LOTUS trial, 554 patients with chronic GERD were randomised to receive either esomeprazole (20-40 mg daily) or LARS. After 5 years, 372 patients remained in the study (esomeprazole, 192; LARS, 180)...
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28126881/eosinophilic-oesophagitis-an-insidious-but-treatable-cause-of-sore-throat
#20
Carla J Swift, John Ong
No abstract text is available yet for this article.
February 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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