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eosinophil oesophagitis

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https://www.readbyqxmd.com/read/27896821/clinical-symptom-tool-that-raises-the-index-of-suspicion-for-eosinophilic-oesophagitis-in-adults-and-drives-earlier-biopsy-for-definitive-diagnosis
#1
U von Arnim, F-W Röhl, S Miehlke, D Jechorek, D Reinhold, T Wex, P Malfertheiner
BACKGROUND: Eosinophilic oesophagitis (EoE) and gastro-oesophageal reflux disease (GERD) present with overlapping symptomatology and it is challenging to distinguish EoE from GERD clinically before endoscopy. AIM: To investigate the prognostic value of a set of clinical symptoms and laboratory values in patients with EoE and GERD. METHODS: In this prospective, single-centre, observational study, we compared clinical and laboratory data from 202 patients with EoE or GERD (10 relevant characteristics)...
November 29, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27888864/oesophageal-disease-gastroesophageal-reflux-disease-barrett-s-oesophagus-achalasia-and-eosinophilic-oesophagitis
#2
Xavier Calvet
The most interesting conclusions and/or advances presented at Digestive Disease Week 2016 were the following: a) gastroesophageal reflux disease: proton pump inhibitor-refractory reflux disease is frequently associated with poor treatment adherence, psychiatric comorbidities and functional gastrointestinal disorders. These possible entities should be investigated in all cases of proton pump inhibitor-refractory reflux disease; b) Barrett's oesophagus: the efficacy of screening remains unclear; however, new minimally-invasive techniques such as the cytosponge allow more effective detection, both of Barrett's oesophagus and Barrett's oesophagus-associated dysplasia or neoplasia; c) achalasia: evidence indicates that peroral endoscopic myotomy is as effective as surgery and is a safer alternative; d) eosinophilic oesophagitis: high-dose proton pump inhibitors are required to rule out proton pump inhibitor-responsive eosinophilic oesophagitis; montelukast is not clearly effective in the treatment of eosinophilic oesophagitis, although moderate efficacy cannot be ruled out...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27878833/presence-of-intraepithelial-food-antigen-in-patients-with-active-eosinophilic-oesophagitis
#3
E V Marietta, D M Geno, T C Smyrk, A Becker, J A Alexander, M Camilleri, J A Murray, D A Katzka
BACKGROUND: Although eosinophilic oesophagitis (EoE) is putatively mediated by an abnormal response to food antigen, the oesophagus is considered relatively impermeable to large molecules. AIM: To assess whether food antigens penetrate the oesophageal mucosa in patients with EoE. METHODS: Anti-gliadin staining was performed in three groups: active EoE, inactive EoE and EoE patients on a low or gluten free diet. To appraise the specificity of our results, we also performed gliadin staining on six patients without oesophageal disease who were consuming gluten...
November 22, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27868307/effects-of-eosinophilic-oesophagitis-on-quality-of-life-in-an-adult-uk-population-a-case-control-study
#4
R Hewett, C Alexakis, A D Farmer, J Ainley, V Chhaya, J O Hayat, A Poullis, J-Y Kang
Eosinophilic oesophagitis (EoE) is a chronic immune-mediated esophageal disease, characterized by symptoms related to esophageal dysfunction and histologically by eosinophil predominant inflammation. Current evidence for an adverse impact on quality of life (QoL) is conflicting and there are no data from a UK population regarding QoL. We conducted a prospective cross-sectional observational study using the Short Form-36 Health Survey, Hospital Dysphagia/Odynophagia Questionnaire, and the EoE Adult Quality of Life Questionnaire to assess QoL and severity of dysphagia in EoE patients, compared to age and gender matched healthy control subjects...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27868216/the-endoscopic-reference-score-shows-modest-accuracy-to-predict-either-clinical-or-histological-activity-in-adult-patients-with-eosinophilic-oesophagitis
#5
J Rodríguez-Sánchez, J Barrio-Andrés, O Nantes Castillejo, E Valdivieso-Cortazar, I Pérez-Martínez, A Boumidi, J A Olmos-Jérez, G Payeras-Llodra, N Alcaide-Suarez, L Ruiz-Rebollo, B Madrigal-Rubiales, E Gonzalez-Obeso, E de la Santa Belda, B López Viedma, J Molina-Infante
BACKGROUND: Conflicting results have been recently reported for the accuracy of the Endoscopic Reference Score (EREFS), an standardised endoscopic classification, to predict the histological activity of eosinophilic oesophagitis (EoE). AIM: To evaluate the accuracy of the EREFS to predict either histological or clinical activity of EoE. METHODS: Prospective multicentre study conducted in eight Spanish centres evaluating adult EoE patients, either naïve or after treatment...
November 20, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27758725/-dysphagia-in-children
#6
E Ten Velde, B C Gonera-de Jong
In this case report we discuss two children with dysphagia. Both presented with difficulties in swallowing and oesophageal impaction of solid food. The first case involves a 16-year-old boy who suffered from dysphagia for many years. After a long diagnostic journey, during which a psychogenic cause was suspected, he was diagnosed with oesophageal achalasia. After a balloon dilatation of the lower oesophageal sphincter his complaints persisted and the treatment procedure was repeated. The second case involves a 15-year-old girl, who presented with a food impaction in the distal oesophagus...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27605525/the-role-of-microaspiration-in-the-pathogenesis-of-gastroesophageal-reflux-related-chronic-cough
#7
Pelin Özdemir, Münevver Erdinç, Rukiye Vardar, Ali Veral, Serdar Akyıldız, Özer Özdemir, Serhat Bor
Background/Aims: Gastroesophageal reflux disease (GERD) is one of the main causes of chronic cough. We evaluated the role of microaspiration in the pathogenesis of reflux-related cough by determining the amount of lipid-laden macrophages in bronchoalveolar lavage specimens. Methods: A total of 161 cases of chronic cough were evaluated, and 36 patients (average age 48.2 years) were recruited for this single center prospective study. Patients with a history of smoking, angiotensin converting enzyme inhibitor usage, any abnormality on pulmonary function tests, abnormal chest X-ray, occupational or environmental exposures, or upper airway cough syndrome were excluded...
September 8, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27592279/primary-eosinophilic-gastrointestinal-disorders-in-children-who-have-received-food-oral-immunotherapy
#8
L Á Echeverría-Zudaire, S Fernández-Fernández, A Rayo-Fernández, C Muñóz-Archidona, R Checa-Rodriguez
BACKGROUND: Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL AND METHODS: A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg...
November 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27471274/lymphocytic-oesophagitis-eosinophilic-oesophagitis-and-compound-lymphocytic-eosinophilic-oesophagitis-i-histological-and-immunohistochemical-findings
#9
C A Rubio, T Ichiya, P T Schmidt
AIMS: To report four histological-immunohistochemical oesophagitis phenotypes. METHODS: Oesophageal biopsies from 311 patients were stained with H&E and with CD3, a T cell marker. Additional immunohistochemical stains (n=413) were performed in 77 cases. RESULTS: Four histological-immunohistochemical oesophagitis phenotypes were recorded: lymphocytic oesophagitis (LyE, ≥40 CD3+ lymphocytes/HPF in CD3 immunostain), eosinophilic oesophagitis (EoE, ≥15 eosinophils/HPF in H&E stain), lymphocytic infiltration (≤39 CD3+/HPF) and compound lymphocytic oesophagitis-eosinophilic oesophagitis (Co LyE-EoE)...
July 28, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27417524/range-of-pathologies-diagnosed-using-a-minimally-invasive-capsule-sponge-to-evaluate-patients-with-reflux-symptoms
#10
Anna L Paterson, Pierre Lao-Sirieix, Maria O'Donovan, Irene Debiram-Beecham, Massimiliano di Pietro, Ahmad Miremadi, Stephen E Attwood, Fiona M Walter, Peter D Sasieni, Rebecca C Fitzgerald
AIMS: Reflux symptoms are highly prevalent and non-specific hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study evaluated whether a non-endoscopic Cytosponge could detect benign oesophageal pathologies and thus have future potential in triaging patients with persistent symptoms. METHODS AND RESULTS: Two complementary cohorts were recruited: 1) Patients with reflux symptoms and no prior endoscopy (n=409); 2) Patients with reflux symptoms referred for endoscopy (n=411)...
July 15, 2016: Histopathology
https://www.readbyqxmd.com/read/27388380/eosinophilic-oesophagitis
#11
REVIEW
Aaron S Bancil, Rhys Hewett, Jamal O Hayat, Andrew Poullis
Eosinophilic oesophagitis is a chronic immune-mediated inflammatory disorder of the oesophagus, characterized by symptoms of dysphagia or food bolus obstruction. Diagnosis is supported by typical histological findings. This article covers pertinent aspects of the disease, pathogenic explanations and treatment options.
July 2016: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/27373195/the-gerdq-questionnaire-and-high-resolution-manometry-support-the-hypothesis-that-proton-pump-inhibitor-responsive-oesophageal-eosinophilia-is-a-gerd-related-phenomenon
#12
E V Savarino, S Tolone, O Bartolo, C de Cassan, R Caccaro, F Galeazzi, L Nicoletti, R Salvador, M Martinato, M Costantini, V Savarino
BACKGROUND: Little is known about the relationship between proton pump inhibitor-responsive oesophageal eosinophilia (PPI-REE), eosinophilic esophagitis (EoE) and gastro-oesophageal reflux disease (GERD). AIM: To compare high resolution manometry features and symptom profiles of patients with EoE, PPI-REE and GERD. METHODS: Consecutive patients diagnosed with EoE or PPI-REE according to international criteria (presence of at least one typical symptom of oesophageal dysfunction; at least 15 eosinophils per high-power field at mid/proximal oesophagus, persistence or resolution of eosinophils after an 8-week PPI trial), and a group of patients with proven GERD and oesophageal eosinophilia, prospectively completed the GerdQ questionnaire and underwent high resolution manometry...
September 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27296681/editorial-management-of-eosinophilic-oesophagitis-efficacy-vs-effectiveness-authors-reply
#13
EDITORIAL
H Philpott, P R Gibson
No abstract text is available yet for this article.
July 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27296680/editorial-management-of-eosinophilic-oesophagitis-efficacy-vs-effectiveness
#14
EDITORIAL
R D Frazier, R Fass
No abstract text is available yet for this article.
July 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27253660/a-new-formulation-of-oral-viscous-budesonide-in-treating-of-paediatric-eosinophilic-oesophagitis-a-pilot-study
#15
Salvatore Oliva, Danilo Rossetti, Paola Papoff, Antonio Tiberti, Paolo Rossi, Sara Isoldi, Jorge Amil Dias, Sandra Lucarelli, Salvatore Cucchiara
BACKGROUND: Oral Viscous Budesonide (OVB) is a recent therapeutic option for Eosinophilic Oesophagitis (EoE) versus dietary restriction and inhaled steroids. This single center, open label, not blinded study aims to evaluate the efficacy and safety of a new, pre-prepared oral viscous budesonide suspension (PVB) in children and adolescents with EoE. METHODS: We treated with PVB 36 children (29 male; median age 12 years) with EoE diagnosed according to ESPGHAN guidelines...
June 2, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27247257/allergy-tests-do-not-predict-food-triggers-in-adult-patients-with-eosinophilic-oesophagitis-a-comprehensive-prospective-study-using-five-modalities
#16
H Philpott, S Nandurkar, S G Royce, F Thien, P R Gibson
BACKGROUND: The use of allergy tests to guide dietary treatment for eosinophilic oesophagitis (EoE) is controversial and data are limited. Aeroallergen sensitisation patterns and food triggers have been defined in Northern Hemisphere cohorts only. AIMS: To determine if allergy tests that are routinely available can predict food triggers in adult patients with EoE. To define the food triggers and aeroallergen sensitisation patterns in a novel Southern Hemisphere (Australian) cohort of patients...
August 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27246069/indications-for-gastrointestinal-endoscopy-in-childhood
#17
D Belsha, R Bremner, M Thomson
Endoscopic examination of the gastrointestinal tract (GIT) for diagnostics and therapy in children has evolved markedly over the last 20 or so years and is now usually undertaken by paediatric endoscopists. Updated diagnostic and management guidelines for common disorders including coeliac disease, gastro-oesophageal reflux disease, eosinophilic oesophagitis and inflammatory bowel disease highlight the central role of endoscopy. Therapeutic endoscopic approaches are also now widely available and further broaden the referral spectrum to include treatment of GIT bleeding, gastrostomy insertion, dilation of strictures and polypectomy...
May 31, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27242158/-first-case-report-of-oesophageal-actinomycosis-in-a-patient-with-active-eosinophilic-oesophagitis
#18
Iago Rodríguez-Lago, Ángel Calderón, Juan Cazallas, María Eulalia Camino, Inmaculada Barredo, José Luis Cabriada
No abstract text is available yet for this article.
May 27, 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27193351/prospective-assessment-of-serum-periostin-as-a-biomarker-for-diagnosis-and-monitoring-of-eosinophilic-oesophagitis
#19
E S Dellon, L L Higgins, R Beitia, S Rusin, J T Woosley, R Veerappan, S R Selitsky, J S Parker, R M Genta, R H Lash, R Aranda, R J Peach, M Grimm
BACKGROUND: Periostin is highly expressed in eosinophilic oesophagitis (EoE), but has not been extensively studied as a non-invasive biomarker. AIM: To assess whether serum periostin distinguished EoE from controls at baseline, had utility for monitoring treatment response, or was associated with IL-13 levels. METHODS: This was a sub-analysis of a prospective cohort study of adults undergoing out-patient upper endoscopy. Incident cases of EoE were diagnosed per consensus guidelines...
July 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27137722/editorial-unravelling-the-mystery-of-the-aetiology-of-eosinophilic-oesophagitis
#20
EDITORIAL
J E Richter
No abstract text is available yet for this article.
June 2016: Alimentary Pharmacology & Therapeutics
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