keyword
MENU ▼
Read by QxMD icon Read
search

Retinal image analysis

keyword
https://www.readbyqxmd.com/read/28542697/incidence-of-atrophic-lesions-in-stargardt-disease-in-the-progression-of-atrophy-secondary-to-stargardt-disease-progstar-study-report-no-5
#1
Rupert W Strauss, Beatriz Muñoz, Alex Ho, Anamika Jha, Michel Michaelides, Saddek Mohand-Said, Artur V Cideciyan, David Birch, Amir H Hariri, Muneeswar G Nittala, SriniVas Sadda, Hendrik P N Scholl
Importance: Outcome measures that are sensitive to disease progression are needed as clinical end points for future treatment trials in Stargardt disease. Objective: To examine the incidence of atrophic lesions of the retinal pigment epithelium in patients with Stargardt disease as determined by fundus autofluorescence imaging. Design, Setting, and Participants: In this retrospective multicenter cohort study, 217 patients 6 years and older at baseline at tertiary referral centers in Europe, the United States, and the United Kingdom who were harboring disease-causing variants in the adenosine triphosphate (ATP)-binding cassette subfamily A member 4 (ABCA4) gene and who met the following criteria were enrolled: (1) at least 1 well-demarcated area of atrophy with a minimum diameter of 300 µm, with the total area of all atrophic lesions being less than or equal to 12 mm2 in at least 1 eye at the most recent visit, and (2) fundus autofluorescence images for at least 2 visits with a minimum of 6 months between at least 2 visits...
May 25, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28542676/detailed-clinical-phenotype-and-molecular-genetic-findings-in-cln3-associated-isolated-retinal-degeneration
#2
Cristy A Ku, Sarah Hull, Gavin Arno, Ajoy Vincent, Keren Carss, Robert Kayton, Douglas Weeks, Glenn W Anderson, Ryan Geraets, Camille Parker, David A Pearce, Michel Michaelides, Robert E MacLaren, Anthony G Robson, Graham E Holder, Elise Heon, F Lucy Raymond, Anthony T Moore, Andrew R Webster, Mark E Pennesi
Importance: Mutations in genes traditionally associated with syndromic retinal disease are increasingly found to cause nonsyndromic inherited retinal degenerations. Mutations in CLN3 are classically associated with juvenile neuronal ceroid lipofuscinosis, a rare neurodegenerative disease with early retinal degeneration and progressive neurologic deterioration, but have recently also been identified in patients with nonsyndromic inherited retinal degenerations. To our knowledge, detailed clinical characterization of such cases has yet to be reported...
May 25, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28542141/an-enhanced-bioluminescence-based-annexin-v-probe-for-apoptosis-detection-in-vitro-and-in-vivo
#3
Trajen Head, Peter Dau, Stephanie Duffort, Pirouz Daftarian, Pratibha M Joshi, Roberto Vazquez-Padron, Sapna K Deo, Sylvia Daunert
The process of controlled cellular death known as apoptosis has an important central role not only in normal homeostatic maintenance of tissues, but also in numerous diseases such as cancer, neurodegenerative, autoimmune, and cardiovascular diseases. As a result, new technologies with the capability to selectively detect apoptotic cells represent a central focus of research for the study of these conditions. We have developed a new biosensor for the detection of apoptotic cells, incorporating the targeted selectivity for apoptotic cells from Annexin V with the sensitivity of bioluminescence signal generation from a serum-stable mutant of Renilla luciferase (RLuc8)...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28538262/parafoveal-microvascular-features-on-optical-coherence-tomography-angiography-in-eyes-with-circumscribed-choroidal-hemangioma
#4
Kareem Sioufi, Emil A T Say, Sandor C Ferenczy, Carol L Shields
PURPOSE: To evaluate parafoveal microvasculature in eyes with circumscribed choroidal hemangioma using optical coherence tomography angiography. METHODS: Fourteen eyes with unilateral circumscribed choroidal hemangioma were imaged using OCT for central macular thickness and optical coherence tomography angiography for superficial and deep foveal avascular zone area, and superficial and deep capillary density (CD), comparing affected and paired fellow eyes. RESULTS: Mean patient age was 53 years, and mean visual acuity was 20/60 in the involved eye and 20/25 in the fellow eye...
May 19, 2017: Retina
https://www.readbyqxmd.com/read/28532448/the-effects-of-a-treatment-combination-of-anti-vegf-injections-laser-coagulation-and-cryotherapy-on-patients-with-type-3-coat-s-disease
#5
Songfeng Li, Guangda Deng, Jinghua Liu, Yan Ma, Hai Lu
BACKGROUND: To examined the curative effect of vitreous injection with ranibizumab,laser coagulation and cryotherapy in treating stage 3 Coats' disease with exudative retinal detachment. METHODS: Seventeen patients with stage 3 Coats' disease were enrolled in the study. All eyes were treated with vitreous injection of ranibizumab as initial treatment, and subsequent treatment depended on the absorption of subretinal fluid, Including cryotherapy and laser photocoagulation...
May 22, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28529759/high-frequency-based-features-for-low-and-high-retina-haemorrhage-classification
#6
Salim Lahmiri
Haemorrhages (HAs) presence in fundus images is one of the most important indicators of diabetic retinopathy that causes blindness. In this regard, accurate grading of HAs in fundus images is crucial for appropriate medical treatment. The purpose of this Letter is to assess the relative performance of statistical features obtained with three different multi-resolution analysis (MRA) techniques and fed to support vector machine in grading retinal HAs. Considered MRA techniques are the common discrete wavelet transform (DWT), empirical mode decomposition (EMD), and variational mode decomposition (VMD)...
February 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28525561/decade-long-profile-of-imaging-biomarker-use-in-ophthalmic-clinical-trials
#7
Edoardo Villani, Domenico Massaro, Matteo Scaramuzzi, Pedram Hamrah, Felipe A Medeiros, Paolo Nucci
Purpose: The purpose of this study was to investigate the use of imaging biomarkers in published clinical trials (CTs) in ophthalmology and its eventual changes during the past 10 years. Methods: We sampled from published CTs in the fields of cornea, retina, and glaucoma between 2005-2006 and 2015-2016. Data collected included year of publication, phase, subspecialty, location, compliance with Consolidated Standards for Reporting Trials, impact factor, presence and use of imaging biomarkers (diagnostic, prognostic and predictive; primary and secondary surrogate endpoints), and use of centralized reading centers...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28525557/retinal-vascular-branching-in-healthy-and-diabetic-subjects
#8
Ting Luo, Thomas J Gast, Tyler J Vermeer, Stephen A Burns
Purpose: To measure the effect of nonproliferative diabetic retinopathy (NPDR) on retinal branching. To compare vascular branching in healthy and diabetic subjects with established biophysical models. Methods: Vascular bifurcations in arteries and veins were imaged in 17 NPDR and 26 healthy subjects with the Indiana adaptive optics scanning laser ophthalmoscope (AOSLO). Vessel measurements were grouped according to parent vessel diameters into large (≤50 ∼ <100 μm) and small (≤20 ∼ <50 μm) sizes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28524134/-oct-morphometric-and-angiographic-parallels-between-different-variants-of-central-serous-chorioretinopathy
#9
I E Panova, T B Shaimov, V A Shaimova
Central serous chorioretinopathy (CSCR) is a frequent cause of vision deterioration. Often it is associated with type 1 neovascularization under the pigment retinal epithelium (RPE). Optical coherence tomography angiography (OCT-angiography) enables non-invasive and contrast-free detection of neovessels in any retinal layer, which makes the method appropriate for diagnostics in CSCR. AIM: to investigate OCT-morphometric and angiographic parallels between different CSCR courses. MATERIAL AND METHODS: The study included 37 patients with CSCR...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28494564/-clinical-observation-and-related-factors-analysis-of-neonatal-asphyxia-complicated-with-retinal-hemorrhage
#10
Q L Pu, Q Y Zhou, J Liu, P Li, H F Huang, H Q Jiang
Objective: To observe and analyze related factors of neonatal asphyxia complicated with retinal hemorrhage. Methods: It was a retrospective case series. Seven hundred and twenty-one cases with neonatal asphyxia after 72 hours of birth were enrolled in this study. Fundus examination was performed on these newborns using the third generation wide-angle digital retina imaging system (RetCamⅢ), and the bleeding level was divided into level I, level Ⅱ and level Ⅲ. The conditions of the newborn and the mother during pregnancy were correlatively analyzed...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28492429/three-dimensional-analysis-of-submacular-perforating-scleral-vessels-by-enhanced-depth-imaging-optical-coherence-tomography
#11
Simon P Rothenbuehler, Peter Maloca, Hendrik P N Scholl, Cyrill Gyger, Andreas Schoetzau, Lorenz Kuske, Nathanael Mosimann, Sandrine A Zweifel, Daniel Barthelmes, Adnan Tufail, Pascal W Hasler
PURPOSE: To analyze submacular perforating scleral vessels (PSVs) using enhanced depth imaging spectral domain optical coherence tomography (EDI-SDOCT). METHODS: Twenty-two eyes of 11 healthy women were included in this retrospective study. Central EDI-SDOCT scans (3 × 4.5 × 1.9 mm, 13.5 mm scan area) were acquired and postprocessed by denoising, manual sclera segmentation, and PSV investigated by five graders. RESULTS: Mean age was 22.4 ± 6...
May 10, 2017: Retina
https://www.readbyqxmd.com/read/28492427/quantitative-optical-coherence-tomography-analysis-of-retinal-degenerative-changes-in-diabetic-macular-edema-and-neovascular-age-related-macular-degeneration
#12
Ernest V Boiko, Dmitrii S Maltsev
PURPOSE: To investigate the relationship of the pre-anti-vascular endothelial growth factor (VEGF) retinal tissue area (RTA) and optical density (ODRT) of the retinal optical slice portion located in the central subfield, and their ratio (RTA/ODRT), in the presence of diabetic macular edema or of inraretinal cystic fluid in neovascular age-related macular degeneration, to central retinal thickness and best-corrected visual acuity after anti-VEGF treatment with ME resolution. METHODS: The optical coherence tomography images and medical records of 33 patients (41 eyes) with neovascular age-related macular degeneration, 15 (21 eyes) with diabetic macular edema and 9 healthy individuals (15 eyes) were retrospectively analyzed...
May 10, 2017: Retina
https://www.readbyqxmd.com/read/28484225/multimodality-analysis-of-hyper-reflective-foci-and-hard-exudates-in-patients-with-diabetic-retinopathy
#13
Sijie Niu, Chenchen Yu, Qiang Chen, Songtao Yuan, Jiang Lin, Wen Fan, Qinghuai Liu
To investigate the correlations between hyper-reflective foci and hard exudates in patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) by spectral-domain optical coherence tomography (SD OCT) images. Hyper-reflective foci in retinal SD OCT images were automatically detected by the developed algorithm. Then, the cropped CFP images generated by the semi-automatic registration method were automatically segmented for the hard exudates and corrected by the experienced clinical ophthalmologist...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481929/horizontal-and-vertical-optic-disc-rotation-the-beijing-eye-study
#14
Yuan Yuan Fan, Jost B Jonas, Ya Xing Wang, Chang Xi Chen, Wen Bin Wei
PURPOSE: To measure the optic disc rotation around the vertical and horizontal disc axis and to evaluate associations with general and ocular parameters. DESIGN: Population-based study. METHODS: In the Beijing Eye Study, 3468 participants (mean age:64.6±9.8 years; range:50-93 years) underwent an ophthalmological examination which included spectral-domain optical coherence tomography (OCT) with enhanced depth imaging. Using the OCT images, we determined the amount of the rotation of the optic disc (defined as Bruch´s membrane opening (BMO)) around the vertical axis and horizontal axis...
2017: PloS One
https://www.readbyqxmd.com/read/28475043/color-retinal-image-enhancement-based-on-luminosity-and-contrast-adjustment
#15
Mei Zhou, Kai Jin, Shaoze Wang, Juan Ye, Dahong Qian
OBJECTIVE: Many common eye diseases and cardiovascular diseases can be diagnosed through retinal imaging. However, due to uneven illumination, image blurring, and low contrast, retinal images with poor quality are not useful for diagnosis, especially in automated image analyzing systems. Here we propose a new image enhancement method to improve color retinal image luminosity and contrast. METHODS: A luminance gain matrix, which is obtained by gamma correction of the value channel in the HSV (Hue, Saturation, and Value) color space, is used to enhance the R, G, and B (Red, Green and Blue) channels, respectively...
May 3, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28474130/blood-vessel-segmentation-in-color-fundus-images-based-on-regional-and-hessian-features
#16
Syed Ayaz Ali Shah, Tong Boon Tang, Ibrahima Faye, Augustinus Laude
PURPOSE: To propose a new algorithm of blood vessel segmentation based on regional and Hessian features for image analysis in retinal abnormality diagnosis. METHODS: Firstly, color fundus images from the publicly available database DRIVE were converted from RGB to grayscale. To enhance the contrast of the dark objects (blood vessels) against the background, the dot product of the grayscale image with itself was generated. To rectify the variation in contrast, we used a 5 × 5 window filter on each pixel...
May 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28474119/optical-coherence-tomography-angiography-analysis-of-retinal-vascular-plexuses-and-choriocapillaris-in-patients-with-type-1-diabetes-without-diabetic-retinopathy
#17
Adriano Carnevali, Riccardo Sacconi, Eleonora Corbelli, Livia Tomasso, Lea Querques, Gianpaolo Zerbini, Vincenzo Scorcia, Francesco Bandello, Giuseppe Querques
AIMS: To analyze retinal vascular plexuses and choriocapillaris by optical coherence tomography angiography (OCT-A) and retinal nerve fiber layer and ganglion cell layer (GCL) by structural optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (T1DM) without diabetic retinopathy (DR). METHODS: A total of 25 eyes of 25 consecutive T1DM patients without signs of DR were prospectively recruited and compared to 25 healthy subjects (control eyes)...
May 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28460051/quantitatively-measured-anatomic-location-and-volume-of-optic-disc-drusen-an-enhanced-depth-imaging-optical-coherence-tomography-study
#18
Lasse Malmqvist, Anne-Sofie Wessel Lindberg, Vedrana Andersen Dahl, Thomas Martini Jørgensen, Steffen Hamann
Purpose: Optic disc drusen (ODD) are found in up to 2.4% of the population and are known to cause visual field defects. The purpose of the current study was to investigate how quantitatively estimated volume and anatomic location of ODD influence optic nerve function. Methods: Anatomic location, volume of ODD, and peripapillary retinal nerve fiber layer and macular ganglion cell layer thickness were assessed in 37 ODD patients using enhanced depth imaging optical coherence tomography...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28460032/association-of-retinal-architecture-intrathecal-immunity-and-clinical-course-in-multiple-sclerosis
#19
Benjamin Knier, Gildas Leppenetier, Carmen Wetzlmair, Lilian Aly, Muna-Miriam Hoshi, Verena Pernpeintner, Viola Biberacher, Achim Berthele, Mark Mühlau, Claus Zimmer, Bernhard Hemmer, Thomas Korn
Importance: Biomarkers to estimate long-term outcomes in patients with multiple sclerosis (MS) and to assign patients to individual treatment regimens are urgently needed. Objective: To assess whether retinal layer volumes are correlated with immune cell subsets and immunoglobulin indices in the cerebrospinal fluid and whether retinal layer volumes alone or in combination with intrathecal variables are associated with worsening of disease in patients with relapsing-remitting MS...
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28459688/a-framework-for-classification-and-segmentation-of-branch-retinal-artery-occlusion-in-sd-oct
#20
Jingyun Guo, Weifang Zhu, Fei Shi, Dehui Xiang, Haoyu Chen, Xinjian Chen
Branch retinal artery occlusion (BRAO) is an ocular emergency which could lead to blindness. Quantitative analysis of BRAO region in the retina is necessary for assessment of the severity of retinal ischemia. In this paper, a fully automatic framework was proposed to segment BRAO regions based on 3D spectral-domain optical coherence tomography (SD-OCT) images. To the best of our knowledge, this is the first automatic 3D BRAO segmentation framework. First, the input 3D image is automatically classified into BRAO of acute phase, BRAO of chronic phase or normal retina using AdaBoost classifier based on combining local structural, intensity, textural features with our new feature distribution analyzing strategy...
April 25, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
keyword
keyword
35500
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"