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Retinal image analysis

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https://www.readbyqxmd.com/read/27906811/measurement-of-radial-peripapillary-capillary-density-in-the-normal-human-retina-using-optical-coherence-tomography-angiography
#1
Tarannum Mansoori, Jayanthi Sivaswamy, Jahnavi Sai Gamalapati, Satish Gooty Agraharam, Nagalla Balakrishna
AIM: To image the radial peripapillary capillary (RPC) network with optical coherence tomography angiography (OCTA) and measure its capillary density (CD) in the normal human retina. MATERIALS AND METHODS: Fifty-two normal participants underwent OCTA imaging with RTVue XR 100 Avanti OCT. The angioflow enface RPCs network was extracted from OCTA and 8 peripapillary sectors with a sector angle of 45 degrees were selected for quantitative analysis: superior nasal, superior temporal, temporal upper, temporal lower, nasal upper, nasal lower, inferior nasal, and inferior temporal...
November 30, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27898471/green-disease-in-optical-coherence-tomography-diagnosis-of-glaucoma
#2
Mohamed S Sayed, Michael Margolis, Richard K Lee
PURPOSE OF REVIEW: Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression. RECENT FINDINGS: Conditions in which OCT color coding may be falsely negative (i...
November 24, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27895460/preoperative-optical-coherence-tomography-visualization-of-epiretinal-membranes-enhances-surgical-strategies
#3
Norihiro Suzuki, Yoshio Hirano, Miyu Ichida, Taneto Tomiyasu, Yuya Esaki, Tsutomu Yasukawa, Yuichiro Ogura
PURPOSE: The aim of this study was to evaluate the usefulness of preoperative optical coherence tomography (OCT) findings in patients with macular epiretinal membrane (ERM) for the planning of surgical strategy. PATIENTS AND METHODS: One hundred twenty-three eyes of 121 patients (49 men, 72 women; mean age, 66 years) with an idiopathic ERM were enrolled. All patients underwent an ophthalmic examination including indirect ophthalmoscopy and OCT (Cirrus HD-OCT 4000 and/or 5000)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27893108/choroidal-thickness-influences-near-infrared-reflectance-intensity-in-eyes-with-geographic-atrophy-due-to-age-related-macular-degeneration
#4
Rosa Dolz-Marco, Orly Gal-Or, K Bailey Freund
Purpose: To evaluate the effects of retinal and choroidal thickness on near-infrared reflectance (NIR) scanning laser ophthalmoscopy in eyes with geographic atrophy (GA) secondary to non-neovascular age-related macular degeneration (AMD). Methods: This was a cross-sectional review of the clinical records and multimodal imaging data of eyes diagnosed with GA secondary to non-neovascular AMD. Imaging modalities included color fundus photography, fundus autofluorescence, NIR, and structural spectral-domain optical coherence tomography (SD-OCT)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27886184/a-view-of-the-current-and-future-role-of-optical-coherence-tomography-in-the-management-of-age-related-macular-degeneration
#5
REVIEW
U Schmidt-Erfurth, S Klimscha, S M Waldstein, H Bogunović
Optical coherence tomography (OCT) has become an established diagnostic technology in the clinical management of age-related macular degeneration (AMD). OCT is being used for primary diagnosis, evaluation of therapeutic efficacy, and long-term monitoring. Computer-based advances in image analysis provide complementary imaging tools such as OCT angiography, further novel automated analysis methods as well as feature detection and prediction of prognosis in disease and therapy by machine learning. In early AMD, pathognomonic features such as drusen, pseudodrusen, and abnormalities of the retinal pigment epithelium (RPE) can be imaged in a qualitative and quantitative way to identify early signs of disease activity and define the risk of progression...
November 25, 2016: Eye
https://www.readbyqxmd.com/read/27882258/dysmorphic-facial-features-and-other-clinical-characteristics-in-two-patients-with-pex1-gene-mutations
#6
Mehmet Gunduz, Ozlem Unal
Peroxisomal disorders are a group of genetically heterogeneous metabolic diseases related to dysfunction of peroxisomes. Dysmorphic features, neurological abnormalities, and hepatic dysfunction can be presenting signs of peroxisomal disorders. Here we presented dysmorphic facial features and other clinical characteristics in two patients with PEX1 gene mutation. Follow-up periods were 3.5 years and 1 year in the patients. Case I was one-year-old girl that presented with neurodevelopmental delay, hepatomegaly, bilateral hearing loss, and visual problems...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27880076/correlation-of-ultra-widefield-fundus-autofluorescence-patterns-with-the-underlying-genotype-in-retinal-dystrophies-and-retinitis-pigmentosa
#7
George Trichonas, Elias I Traboulsi, Justis P Ehlers
PURPOSE: Ultra-widefield fundus autofluorescence (UW-FAF) allows the characterization of the peripheral retinal features of vitreoretinal diseases. The purpose of this study was to examine possible genotypic/phenotypic correlations of UW-FAF patterns in patients with a variety of retinal dystrophies and retinitis pigmentosa (RP). METHODS: An IRB-approved retrospective consecutive case series study was performed of genetically characterized retinal dystrophy or RP patients who underwent UW-FAF imaging...
November 23, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27872047/detection-of-mild-papilloedema-in-posterior-uveitis-using-spectral-domain-optical-coherence-tomography
#8
A Philiponnet, C Vardanian, A Malcles, C Pochat, R Sallit, L Kodjikian
OBJECTIVE: To compare two methods for diagnosing mild papilloedema (PO) using peripapillary total retinal (PTR) and retinal nerve fibre layer (RNFL) thickness measurement by spectral domain optical coherence tomography (OCT) in patients suffering from posterior uveitis. METHODS: 17 eyes in 17 patients with PO caused by posterior uveitis, 15 eyes in 15 patients with uveitis but with no PO based on slit lamp analysis were studied. High-quality OCT fundus images were analysed and graded by three masked observers using the Modified Frisén Scale...
November 21, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27871762/clinical-and-histopathologic-ocular-findings-in-disseminated-mycobacterium-chimaera-infection-after-cardiothoracic-surgery
#9
Sandrine A Zweifel, Daniela Mihic-Probst, Christine A Curcio, Daniel Barthelmes, Andrea Thielken, Peter M Keller, Barbara Hasse, Christian Böni
PURPOSE: To investigate and characterize clinical and histopathologic ocular findings in patients with disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery. DESIGN: Observational case series. PARTICIPANTS: Five white patients (10 eyes). METHODS: Analysis of clinical ocular findings, including visual acuity, slit-lamp biomicroscopy, spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence (FAF), and fluorescein angiography/indocyanine green (ICG) angiography findings, of patients with a disseminated M...
November 18, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27867732/dynamic-contrast-optical-coherence-tomography-images-transit-time-and-quantifies-microvascular-plasma-volume-and-flow-in-the-retina-and-choriocapillaris
#10
Conrad W Merkle, Conor Leahy, Vivek J Srinivasan
Despite the prevalence of optical imaging techniques to measure hemodynamics in large retinal vessels, quantitative measurements of retinal capillary and choroidal hemodynamics have traditionally been challenging. Here, a new imaging technique called dynamic contrast optical coherence tomography (DyC-OCT) is applied in the rat eye to study microvascular blood flow in individual retinal and choroidal layers in vivo. DyC-OCT is based on imaging the transit of an intravascular tracer dynamically as it passes through the field-of-view...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27865693/-point-by-point-approach-to-structure-function-correlation-of-glaucoma-on-the-ganglion-cell-complex-in-the-posterior-pole
#11
M Zeitoun
PURPOSE: To try to establish a "point by point" relationship between the local thickness of the retinal ganglion cell complex and its sensitivity. MATERIALS AND METHODS: In total, 104 glaucomatous eyes of 89 patients with a confirmed 24-2 visual field, were measured by superimposing the visual field, using imaging software, with the Wide 40° by 30° measurements of retinal ganglion cell complex obtained from the Topcon(©) 3D 2000 OCT, after upward adjustment, inversion and scaling...
November 16, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27862073/n-methyl-n-nitrosourea-induces-retinal-degeneration-in-the-rat-via-the-inhibition-of-nf-%C3%AE%C2%BAb-activation
#12
Yu Xiong, Hong-Pei Ji, Wei-Tao Song, Ye-Wei Yin, Chao-Hua Xia, Bei Xu, Yi Xu, Xiao-Bo Xia
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. N-methyl-N-nitrosourea (MNU) is an alkylating toxicant that induces photoreceptor cell death resembling hereditary RP. This study aimed to investigate the role of nuclear factor κB (NF-κB) in MNU-induced photoreceptor degeneration. Adult rats received a single intraperitoneal injection of MNU (60 mg/kg bodyweight). Hematoxylin and eosin staining demonstrated progressive outer nuclear layer (ONL) loss after MNU treatment...
November 13, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27858248/morphology-filter-bank-for-extracting-nodular-and-linear-patterns-in-medical-images
#13
Ryutaro Hashimoto, Yoshikazu Uchiyama, Keiichi Uchimura, Gou Koutaki, Tomoki Inoue
PURPOSE: Using image processing to extract nodular or linear shadows is a key technique of computer-aided diagnosis schemes. This study proposes a new method for extracting nodular and linear patterns of various sizes in medical images. METHODS: We have developed a morphology filter bank that creates multiresolution representations of an image. Analysis bank of this filter bank produces nodular and linear patterns at each resolution level. Synthesis bank can then be used to perfectly reconstruct the original image from these decomposed patterns...
November 17, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27854139/foveal-layer-morphology-detected-on-spectral-domain-optical-coherence-tomography-and-its-correlation-with-visual-acuity-in-asian-indian-premature-infants-in-their-first-year-of-life
#14
Chaitra Jayadev, Anand Vinekar, Shwetha Mangalesh, Mathew Kurian Kummelil, Anupama Kiran Kumar, Vasudha Kemmanu, Munusamy Sivakumar, Padmamalini Mahendradas, Kavitha Avadhani, Noel Bauer, Carroll Ab Webers, Bhujang Shetty
PURPOSE: To report foveal microanatomy imaged on handheld spectral domain optical coherence tomography (SDOCT) and correlate it with visual acuity in Asian Indian premature infants. METHODS: A retrospective analysis of 32 Asian Indian premature infants, 10 with Type 2 retinopathy of prematurity (ROP), were imaged between 3 and 12 months of corrected postmenstrual age (PMA) on the handheld SDOCT (Envisu 2300, Bioptigen, DNC, USA). The foveal findings on these images were correlated with visual acuity measured using Teller acuity cards...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27852400/-diagnostic-performance-of-laser-retinal-imaging-in-the-epiretinal-membrane
#15
Y J Huo, L L Yang, W B Wei
Objective: To determine the diagnostic performance of confocal scanning laser ophthalmoscope (cSLO)-based retinal imaging in the epiretinal membrane (ERM) patients. Methods: Prospective case series study. Twenty-six patients (32 eyes) with ERM determined by spectral domain optical coherence tomography (SD-OCT) were recruited from June 2015 to October 2015 in the Beijing Tongren Eye Center. All subjects underwent retinal imaging using the cSLO-based Heidelberg MultiColor (Spectralis HRA-2; Heidelberg Engineering) technology and the traditional color fundus camera...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847640/choroidal-thickness-in-older-patients-with-central-serous-chorioretinopathy
#16
Caio V Regatieri, Eduardo A Novais, Lauren Branchini, Mehreen Adhi, Emily D Cole, Ricardo Louzada, Mark Lane, Elias Reichel, Jay S Duker
BACKGROUND: To investigate the choroidal thickness in older patients with central serous chorioretinopathy (CSCR) compared to age-matched normal subjects. METHODS: Fifteen patients (30 eyes) with CSCR, all aged ≥60 years, and 21 age-matched normal subjects (21 eyes) underwent high-definition raster scanning using SD-OCT. Both eyes from CSCR patients were included in the analysis. The eyes in patients with CSCR were divided into two groups: active CSCR (17 eyes) if there was foveal-involving subretinal fluid and inactive contralateral eye group (13 eyes)...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847626/correlation-of-biomarkers-thiobarbituric-acid-reactive-substance-nitric-oxide-and-central-subfield-and-cube-average-thickness-in-diabetic-retinopathy-a-cross-sectional-study
#17
Surabhi Ruia, Sandeep Saxena, S Prasad, Shashi R Sharma, Levent Akduman, Vinay K Khanna
BACKGROUND: To evaluate the role of thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) as biochemical biomarkers and central subfield (CST) and cube average thickness (CAT) as biomarkers for medical imaging in diabetic retinopathy. METHODS: Forty consecutive cases of diabetic retinopathy and 20 healthy controls were included. Cases were divided into two groups: non proliferative diabetic retinopathy (n = 20) and proliferative diabetic retinopathy (n = 20) according to ETDRS classification...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27843286/effect-of-cataract-surgery-on-subfoveal-choroidal-and-ganglion-cell-complex-thicknesses-measured-by-enhanced-depth-imaging-optical-coherence-tomography
#18
Erkan Celik, Burcin Cakır, Elif Betul Turkoglu, Emine Doğan, Gursoy Alagoz
PURPOSE: We aimed to evaluate the effect of cataract surgery on subfoveal choroidal thickness (CT) and ganglion cell complex (GCC) thickness, as measured by enhanced depth imaging-optical coherence tomography (OCT). METHODS: This prospective study included 30 eyes of 30 patients who had undergone uneventful phacoemulsification surgery for senile cataract but had no previous ocular surgery or other ocular abnormality. Best-corrected visual acuity, slit-lamp biomicroscopy, intraocular pressure, axial length, and central corneal thickness were measured preoperatively...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27834640/speckle-reduction-in-3d-optical-coherence-tomography-of-retina-by-a-scan-reconstruction
#19
Jun Cheng, Dacheng Tao, Ying Quan, Damon Wing Kee Wong, Gemmy Chui Ming Cheung, Masahiro Akiba, Jiang Liu
Optical coherence tomography (OCT) is a micrometer-scale, cross-sectional imaging modality for biological tissue. It has been widely used for retinal imaging in ophthalmology. Speckle noise is problematic in OCT. A raw OCT image/volume usually has very poor image quality due to speckle noise, which often obscures the retinal structures. Overlapping scan is often used for speckle reduction in a 2D line-scan. However, it leads to an increase of the data acquisition time. Therefore, it is unpractical in 3D scan as it requires a much longer data acquisition time...
October 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27833968/posterior-vitreous-detachment-and-macular-anatomical-changes-a-tomographic-electroretinographic-study
#20
Alin Ştefan Ştefănescu-Dima, Cornelia Andreea Corîci, Maria Rodica Mănescu, Teodor Nicuşor Sas, Maria Iancău, Carmen LuminiŢa Mocanu
AIM: Posterior vitreous detachment (PVD) is a physiological phenomenon due to aging characterized by separation of the vitreous cortex from the retina and may induce a variety of pathological events at the vitreoretinal junction. The aim of this study is to highlight in vivo anatomical and functional changes in early stages of PVD allowing the correct treatment. MATERIAL AND METHODS: Non-consecutive case series; optical coherence tomography (OCT) relies on analyzing the reflectivity of coherent light from different anatomical interfaces within posterior vitreous and retinal histological layers, thus acquiring transverse sections through vitreoretinal interface, sensory retina, retinal pigment epithelium and choroid...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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