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Christian Enders, Achim Schneider, Oliver Keis, Claudia Grab-Kroll, Max Loidl, Jürgen Kampmeier, Gerhard K Lang, Jens Ulrich Werner
BACKGROUND: An increased demand for young physicians in Germany is causing increased competition to attract the best minds, even during their undergraduate studies. Therefore, it is the task of the university hospitals to offer their students the best possible courses in order to arouse interest in the relevant subject area. We therefore examined the impact of an ophthalmosurgical wet lab on teaching undergraduate medical students. MATERIAL/METHODS: Undergraduate medical students were offered voluntary participation in the ophthalmosurgical wet lab during an ophthalmology block week...
July 19, 2018: Klinische Monatsblätter Für Augenheilkunde
Kimberly Burnside, Kristyn Wright, Diane Poulin-Dubois
According to the social motivation theory, orienting toward social elements of the environment should be related to sociocognitive abilities, such as theory of mind (ToM), in both typically developing children and children with autism spectrum disorder. The objective of the current study was to assess whether social orienting skills predict ToM abilities in preschoolers by using two social orienting tasks (biological motion and face preference) and an implicit false belief task. A total of 38 children, aged 2-4 years, participated in this study...
July 12, 2018: Journal of Experimental Child Psychology
Katrine Bjune, Hilde Sundvold, Trond P Leren, Soheil Naderi
BACKGROUND AND AIMS: Induction of low-density lipoprotein receptor (LDLR) plays a significant role in reduction of plasma LDL-cholesterol (LDL-C) levels. Therefore, strategies that enhance the protein level of LDLR provide an attractive therapeutic target for the treatment of hypercholesterolemia. With this aim in mind, we concentrated our effort on studying the role of AKT kinase in regulation of LDLR levels and proceeded to examine the effect of MK-2206, an allosteric and highly selective AKT inhibitor, on LDLR expression...
July 7, 2018: Atherosclerosis
Antoine de Weck, Javad Golji, Michael D Jones, Joshua M Korn, Eric Billy, E Robert McDonald, Tobias Schmelzle, Hans Bitter, Audrey Kauffmann
Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-function viability screens. However, a bias exists that makes it difficult to assess the true essentiality of genes located in amplicons, since the entire amplified region can exhibit lethal scores. These false-positive hits can either be discarded from further analysis, which in cancer models can represent a significant number of hits, or methods can be developed to rescue the true-positives within amplified regions. We propose two methods to rescue true positive hits in amplified regions by correcting for this copy number artefact...
July 19, 2018: PLoS Computational Biology
Mathew P Varghese, Ragavendrasamy Balakrishnan, Subramanya Pailoor
Background Type 2 diabetes mellitus [T2DM] is one of the leading causes for mortality. This study examined the role of an self-awareness based guided meditation practice, Cyclic Meditation [CM] on perceived stress, anxiety, depression, sleep and quality of life in T2DM patients. Design A single arm pre-post design was used for the study. Setting The study was conducted in an auditorium for general public diagnosed with T2DM in Ernakulam, Kerala, India. Subjects Subjects were 30 T2DM patients, both male and female of age 50...
July 19, 2018: Journal of Complementary & Integrative Medicine
Gökhan Yırgın, İhsan Ateş, Bilal Katipoğlu, Burak Furkan Demir, Nisbet Yılmaz
A 29-year-old male patient was treated and followed up for a pulmonary embolism. The patient had no relevant medical history, other than the fact that he had smoked bonzai, a synthetic cannabinoid derivative, for 2 years. Hypercoagulability tests were normal. The use of synthetic cannabinoids is increasing in the young population and should be kept in mind among the causes of pulmonary embolism.
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Stefano Fedi, Martina Cappelletti, Federica Sandri, Raymond J Turner, Davide Zannoni
Kimura and co-workers (Kimura N et al. Int J Syst Evol Microbiol 2018;68:1429-1435) recently proposed renaming the obligate aerobe Pseudomonas pseudoalcaligenes KF707 as Pseudomonas furukawiisp. nov. type strain KF707. Since the first quasi-complete genome sequence of KF707 was reported in 2012 (accession number: PRJNA83639) numerous reports on chemotaxis and function/composition of the respiratory redox chain of KF707 have been published, demonstrating that KF707 contains three cheA genes for aerobic motility, four cytochrome oxidases of c(c)aa3- and cbb3-type and one bd-type quinol oxidase...
July 19, 2018: International Journal of Systematic and Evolutionary Microbiology
Meirav Hen
Teachers in hospitals are a unique phenomenon. Their students are sick, hospitalized children with a range of physical, emotional, and cognitive needs. Teachers are expected to be dynamic, flexible, creative, open-minded, and efficient to function in the most appropriate manner. However, a recent study showed that these teachers tend to procrastinate on some of the most common tasks that teachers perform on a daily basis in the regular school system. The present study was an initial investigation into the reasons for procrastination in teachers who work in two hospitals in Israel...
July 2018: Journal of Prevention & Intervention in the Community
Ekaterina Denkova, Emily G Brudner, Kristen Zayan, Joseph Dunn, Amishi P Jha
Mind wandering (MW) has been recently investigated in many studies. It has been suggested that, during MW, processing of perceptual stimuli is attenuated in favor of internal thoughts, a phenomenon referred to as perceptual decoupling. Perceptual decoupling has been investigated in ERP studies, which have used relatively simple perceptual stimuli, yet it remains unclear if MW can impact the perceptual processing of complex stimuli with real-world relevance. Here, we investigated the impact of MW on behavioral and neural responses to faces...
July 19, 2018: Journal of Cognitive Neuroscience
Sudeep Bhatia
This article examines how semantic memory processes influence the items that are considered by decision makers in memory-based preferential choice. Experiments 1A through 1C ask participants to list the choice items that come to their minds while deliberating in a variety of everyday choice settings. These experiments use semantic space models to quantify the semantic relatedness between pairs of retrieved items and find that choice item retrieval displays robust semantic clustering effects, with retrieved items increasing the retrieval probabilities of related items...
July 19, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
Seung Suk Kang, Christopher R Erbes, Greg J Lamberty, Paul Thuras, Scott R Sponheim, Melissa A Polusny, Amy C Moran, Abraham C Van Voorhis, Kelvin O Lim
OBJECTIVE: Transcendental Meditation (TM) is a mental technique using a mantra to facilitate meditation. TM has a potential for treating symptoms of posttraumatic stress disorder (PTSD), but its clinical efficacy remains to be clarified. This pilot study evaluated the acceptability, preliminary effectiveness, and neurophysiology of TM for veterans with PTSD. METHOD: Twenty-nine veterans (20.7% female) were recruited from a major medical center and enrolled in the study...
July 19, 2018: Psychological Trauma: Theory, Research, Practice and Policy
Sangar M Faroq Abdulrahman, Serkan Teksöz, Sina Ferahman, Süleyman Demiryas, Yusuf Bükey, Ateş Özyiğin
Missed gland is an extremely rare condition. It is a mediastinal thyroid mass found after total thyroidectomy. We report a case of missed gland. The patient underwent total thyroidectomy due to multinodular goiter and thyroid stimulating hormone levels did not increase after surgery. Pathological tests revealed a micropapillary carcinoma. Thyroid ultrasonography and scintigraphy scan revealed mediastinal thyroid mass. The patient underwent redo surgery without sternotomy and there was no morbidity after the second surgical procedure...
2018: Turkish Journal of Surgery
Cemal Kaya, Emre Bozkurt, Pınar Yazıcı, Ufuk Oğuz İdiz, Mert Tanal, Mehmet Mihmanlı
Objective: To evaluate the diagnostic and treatment approaches for patients diagnosed with mesenteric panniculitis. Material and Methods: We retrospectively reviewed all patients diagnosed with mesenteric panniculitis between January 2010 and March 2016. We recorded the demographic features, clinical symptoms, laboratory values, radiological methods, treatment approach, and outcomes of the patients. Results: We evaluated 22 patients (17 male and five female) with a mean age of 45...
2018: Turkish Journal of Surgery
Richard D Sontheimer
James Neil Gilliam, MD, was an American academic physician who was trained in internal medicine, dermatology, dermatopathology and rheumatology. This "quadruple-threat" profile of postgraduate medical training provided him with a rather unique perspective on genetically-complex, environmentally-impacted human autoimmune disorders such as lupus erythematosus (LE). Both the skin and vital internal organs can be damaged by LE autoimmunity. And, LE is clinically-expressed quite variably from one individual to another making prognosis difficult...
June 2018: Annals of Translational Medicine
Marilia Carabotti, Rosario Cuomo, Giovanni Barbara, Fabio Pace, Paolo Andreozzi, Cesare Cremon, Bruno Annibale
Background: Clinical features and lifestyle factors associated with diverticulosis compared to diverticular disease (DD), either symptomatic uncomplicated diverticular disease (SUDD) or in patients who have had previous diverticulitis (PD), are unclear. Objective: The objective of this article is to compare cross-sectionally demographic and clinical features and quality of life (QoL) in diverticulosis, SUDD and PD patients. Methods: The REMAD Registry is a prospective, observational, multicentre, cohort study...
July 2018: United European Gastroenterology Journal
Ruta Sawant, Sujit Sansgiry
Background: Medication side-effects often arouse fear in the minds of consumers and therefore need to be communicated in a manner such that the intended message is clearly understood, without causing undue fear. Objectives: Considering the message format and contextual factors that influence perceptions of risk, this study aimed at assessing the interaction effects of message format and contextual factors (rate of occurrence and severity) on risk perception of medication side-effects...
April 2018: Pharmacy Practice
Carina Remmers, Johannes Zimmermann, Alice Buxton, Hans-Peter Unger, Sander L Koole, Christine Knaevelsrud, Johannes Michalak
BACKGROUND: Mindfulness-based interventions (MBIs) are effective in treating major depression. Because mindfulness involves monitoring and accepting current experiences, it may lead people resolve incongruencies between emotional responses that would otherwise remain unnoticed. Mindfulness may thus foster congruence between implicit and explicit emotions. The current randomized controlled trial tested this notion. METHODS: N = 39 patients with an acute depressive episode were randomly assigned to an 8-week MBI (n = 24) or a psychopharmacological consultation condition (n = 15)...
July 18, 2018: Clinical Psychology & Psychotherapy
Haruhiro Inoue, Hironari Shiwaku, Katsuhiko Iwakiri, Manabu Onimaru, Yasutoshi Kobayashi, Hitomi Minami, Hiroki Sato, Seigo Kitano, Ryuichi Iwakiri, Nobuo Omura, Kazunari Murakami, Norio Fukami, Kazuma Fujimoto, Hisao Tajiri
Peroral endoscopic myotomy (POEM) is a novel technique developed in Japan; it is used to treat esophageal achalasia and esophageal motility disorders. This technique has been rapidly accepted and widely disseminated throughout our clinical practice because of its low invasiveness, technical novelty, and high efficacy. Since the advent of POEM, there have been no clinical guidelines that clearly indicated its standard of care, and these guidelines have been anticipated both nationally and internationally by clinicians who engage in POEM practice...
July 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Roberto J Rivero-Soto, JoAnn Coleman, Vanita Ahuja
The Society of Surgical Alimentary Tract (SSAT) Resident Education Committee aim is to facilitate resident participation in the annual meeting and foster the education of the next generation of gastrointestinal. The SSAT "Residents Corner" was developed as a video-blog highlighting areas of interest for surgical trainees looking to focus on a career in gastrointestinal surgery. The topics covered are to make surgical education more accessible, one way is to highlight leaders in the field who discuss their journey...
July 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Myrthe Faber, Caitlin Mills
No abstract text is available yet for this article.
July 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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