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Optic disc detection

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https://www.readbyqxmd.com/read/29140751/further-delineation-of-the-oculoauricular-syndrome-phenotype-a-new-family-with-a-novel-truncating-hmx1-mutation
#1
Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Mennat I Mehrez, Ahmad M Kamal, Mohamed B Taher, Hanan H Afifi
Biallelic HMX1 mutations cause a very rare autosomal recessive genetic disorder termed as oculoauricular syndrome (OAS) because it is characterized only by the combination of eye and ear anomalies. We identified a new family bringing to three the total families reported with this disorder. Our proband presented with anteriorly protruded ears and malformed ear pinnae in association with microphthalmia, congenital cataract, microcornea, and iris and optic disc colobomata. Additionally, he had high and broad forehead with asymmetry giving a recognizable facial gestalt...
November 15, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29136839/chromisense-a-colourimetric-lab-on-a-disc-sensor-for-chromium-speciation-in-water
#2
G Duffy, I Maguire, Brendan Heery, Pauline Gers, J Ducrée, F Regan
The development of a centrifugal device for quantitative analysis of both chromium (III) and (VI) species in water is reported. ChromiSense is a colourimetric sensor system that has been applied to the measurement of chromium in spiked river water samples. For analysis, the sample is loaded into a reservoir on the disposable microfluidic disc, along with reagents. A centrifugal force is created by spinning the disc to pump liquids through microchannels, causing them to mix and react to form a coloured product...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29124453/a-machine-learning-ensemble-classifier-for-early-prediction-of-diabetic-retinopathy
#3
Somasundaram S K, Alli P
The main complication of diabetes is Diabetic retinopathy (DR), retinal vascular disease and it leads to the blindness. Regular screening for early DR disease detection is considered as an intensive labor and resource oriented task. Therefore, automatic detection of DR diseases is performed only by using the computational technique is the great solution. An automatic method is more reliable to determine the presence of an abnormality in Fundus images (FI) but, the classification process is poorly performed...
November 9, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29122818/optical-coherence-tomographic-angiography-identifies-peripapillary-microvascular-dilation-and-focal-non-perfusion-in-giant-cell-arteritis
#4
Eric D Gaier, Aubrey L Gilbert, Dean M Cestari, John B Miller
AIMS: We set out to determine the optical coherence tomographic angiography (OCT-A) characteristics of arteritic anterior ischaemic optic neuropathy (AAION) in the context of giant cell arteritis (GCA). METHODS: This is an observational case series of four patients with AAION secondary to GCA, three with unilateral AAION and one with bilateral AAION. We reviewed the charts, fundus photography, visual fields, fluorescein angiography (FA) and OCT-A images for all patients to identify a unifying theme in a range of AAION clinical severity...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29120977/use-of-a-scan-ultrasound-and-optical-coherence-tomography-to-differentiate-papilledema-from-pseudopapilledema
#5
Roberto Saenz, Han Cheng, Thomas C Prager, Laura J Frishman, Rosa A Tang
SIGNIFICANCE: Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions. PURPOSE: To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT) in differentiating papilledema associated with idiopathic intracranial hypertension from pseudopapilledema...
November 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29109901/posterior-polar-central-choroidal-dystrophy-a-case-report
#6
Funda Dikkaya, Mustafa Özsütçü, Merve Özbek, Sevil Karaman Erdur, Fevzi Şentürk
A 52-year-old male presented with a 25-year history of decreasing vision. Best corrected visual acuity was 0.3 in his right and 0.2 in his left eye. Fundoscopic examination showed bilateral symmetric atrophy of the retinal pigment epithelium and choriocapillaris in the posterior polar areas between vascular arcades and surrounding the optic disc. On fluorescein angiography, the large choroidal vessels beneath these affected regions were easily seen. Fundus autofluorescence imaging showed clearly defined hypoautofluorescent areas that corresponded to the aforementioned lesions...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29099668/successful-conservative-treatment-of-massive-choroidal-relapse-in-2-retinoblastoma-patients-monitored-by-ultrasound-biomicroscopy-and-or-spectral-domain-optic-coherence-tomography
#7
Christina Stathopoulos, Marie-Claire Gaillard, Francesco Puccinelli, Philippe Maeder, Doris Hadjistilianou, Maja Beck-Popovic, Francis L Munier
PURPOSE: To report the occurrence and management of secondary choroidal infiltration in two retinoblastoma (rb) patients. METHODS: Fundus examination and imaging with spectral domain optical coherence tomography (SD-OCT), B-scan ultrasonography (B-scan), and ultrasound biomicroscopy (UBM). RESULTS: Case 1: A 19-month-old girl with multifocal unilateral group B rb pretreated with intravenous chemotherapy (IVC) was referred for further management...
November 3, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29090107/optic-disc-image-subtraction-as-an-aid-to-detect-glaucoma-progression
#8
Navid Amini, Reza Alizadeh, Nucharee Parivisutt, EunAh Kim, Kouros Nouri-Mahdavi, Joseph Caprioli
PURPOSE: To present a digital image subtraction technique to alert clinicians to signs of glaucomatous optic disc progression. METHODS: Ninety-two glaucomatous eyes (65 patients) were included. Thirty-three eyes were identified as progressive and 59 as stable based on comparison of baseline and follow-up stereoscopic disc photographs by three masked glaucoma specialists. The disc images were aligned and converted to gray scale and underwent histogram matching to enhance contrast and account for illumination differences...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29090058/central-retinal-vein-occlusion-like-appearance-a-precursor-stage-in-evolution-of-frosted-branch-angiitis
#9
Babulal Kumawat, Koushik Tripathy, Pradeep Venkatesh, Rohan Chawla, Yog Raj Sharma
PURPOSE: To report a young man with a central retinal vein occlusion (CRVO)-like appearance which later evolved to frosted branch angiitis (FBA). CASE REPORT: As 28-year-old Indian man presented with optic disc swelling, hyperemia, peripapillary hemorrhages, and dilated tortuous veins in the left eye, 6 months after being diagnosed with idiopathic FBA in the right eye. Within 3 days of presentation, the left eye developed FBA, which was promptly and successfully treated with oral steroids...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29073912/automatic-non-proliferative-diabetic-retinopathy-screening-system-based-on-color-fundus-image
#10
Zhitao Xiao, Xinpeng Zhang, Lei Geng, Fang Zhang, Jun Wu, Jun Tong, Philip O Ogunbona, Chunyan Shan
BACKGROUND: Non-proliferative diabetic retinopathy is the early stage of diabetic retinopathy. Automatic detection of non-proliferative diabetic retinopathy is significant for clinical diagnosis, early screening and course progression of patients. METHODS: This paper introduces the design and implementation of an automatic system for screening non-proliferative diabetic retinopathy based on color fundus images. Firstly, the fundus structures, including blood vessels, optic disc and macula, are extracted and located, respectively...
October 26, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29050924/-progression-of-nerve-fiber-layer-defects-in-retrobulbar-optic-neuritis-by-the-macular-ganglion-cell-complex
#11
D Hong, C Bosc, F Chiambaretta
INTRODUCTION: Recent studies with SD OCT had shown early axonal damage to the macular ganglion cell complex (which consists of the three innermost layers of the retina: Inner Plexiform Layer [IPL], Ganglion Cell Layer [GCL], Retinal Nerve Fibre layer [RNFL]) in optic nerve pathology. Retrobulbar optic neuritis (RBON), occurring frequently in demyelinating diseases, leads to atrophy of the optic nerve fibers at the level of the ganglion cell axons, previously described in the literature...
November 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29049716/bone-marrow-derived-cell-recruitment-to-the-neurosensory-retina-and-retinal-pigment-epithelial-cell-layer-following-subthreshold-retinal-phototherapy
#12
Sergio Caballero, David L Kent, Nilanjana Sengupta, Sergio Li Calzi, Lynn Shaw, Eleni Beli, Leni Moldovan, James M Dominguez, Ramana S Moorthy, Maria B Grant
Purpose: We investigated whether subthreshold retinal phototherapy (SRPT) was associated with recruitment of bone marrow (BM)-derived cells to the neurosensory retina (NSR) and RPE layer. Methods: GFP chimeric mice and wild-type (WT) mice were subjected to SRPT using a slit-lamp infrared laser. Duty cycles of 5%, 10%, 15%, and 20% (0.1 seconds, 250 mW, spot size 50 μm) with 30 applications were placed 50 to 100 μm from the optic disc. In adoptive transfer studies, GFP+ cells were given intravenously immediately after WT mice received SRPT...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29044550/proliferative-diabetic-retinopathy-characterization-based-on-fractal-features-evaluation-on-a-publicly-available-data-set
#13
José Ignacio Orlando, Karel van Keer, João Barbosa Breda, Hugo Luis Manterola, Matthew B Blaschko, Alejandro Clausse
PURPOSE: Diabetic retinopathy (DR) is one of the most widespread causes of preventable blindness in the world. The most dangerous stage of this condition is proliferative DR (PDR), in which the risk of vision loss is high and treatments are less effective. Fractal features of the retinal vasculature have been previously explored as potential biomarkers of DR, yet the current literature is inconclusive with respect to their correlation with PDR. In this study we experimentally assess their discrimination ability to recognize PDR cases...
October 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29027884/accuracy-and-reliability-of-a-handheld-nonmydriatic-fundus-camera-for-the-remote-detection-of-optic-disc-edema
#14
Lulu Bursztyn, Maria A Woodward, Wayne T Cornblath, Hilary M Grabe, Jonathan D Trobe, Leslie Niziol, Lindsey B De Lott
BACKGROUND: Optic disc edema can be an important indicator of serious neurological disease, but is poorly detected using the direct ophthalmoscope. Portable fundus photography may overcome this difficulty. INTRODUCTION: The purpose of this study was to determine the sensitivity and specificity of a handheld, nonmydriatic fundus camera for the detection of optic disc edema. MATERIALS AND METHODS: Retrospective review of nonmydriatic optic disc photographs taken with a portable fundus camera (Pictor Plus; Volk Optical, Mentor, OH) from the University of Michigan Neuro-Ophthalmology Clinics...
October 13, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28986994/microvasculature-dropout-detected-by-the-optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#15
Yi Song, Jing-Yu Min, Lei Mao, Yuan-Yuan Gong
OBJECTIVE: To investigate microcirculation characteristics of peripapillary superficial retina and optic disc in eyes with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA). METHODS: Forty-one eyes of 30 NAION patients and 30 eyes of 30 normal subjects were evaluated with OCTA (AngioVue, Optovue). The whole vessel density, inside disc vessel density, peripapillary vessel density, and vessel densities based on the sectorial division in the nerve head mode peripapillary superficial retina and RPC mode optic disc were measured respectively...
October 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28984710/risk-factors-associated-with-glaucomatous-progression-in-pseudoexfoliation-patients
#16
Yeji Moon, Kyung Rim Sung, Joon Mo Kim, Seong Hee Shim, Chungkwon Yoo, Ji Hye Park
PURPOSE: To investigate risk factors associated with glaucomatous progression in pseudoexfoliation glaucoma (PXG) patients. PATIENTS AND METHODS: A retrospective observational study with a total of 48 PXG patients and age-, sex-, and visual-field (VF) test mean-deviation (MD)-matched 48 primary open angle glaucoma (POAG) patients recruited from three university-based hospitals. Glaucomatous progression was defined by two criteria, either optic disc/retinal nerve fiber layer photographic assessment or serial VF data...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28982124/prevalence-of-retinal-nerve-fiber-layer-defects-the-korea-national-health-and-nutrition-examination-survey-2008-2012
#17
Kyeong Ik Na, Jin Wook Jeoung, Won June Lee, Young Kook Kim, Chan Yun Kim, Ki Ho Park
PURPOSE: To investigate the prevalence and associated factors of retinal nerve fiber layer defects (RNFLDs) in a Korean population. METHODS: The Korea National Health and Nutrition Examination Survey (KNHANES) is a population-based study using a complex, stratified, multistage, probability-cluster survey. We performed a review of 2008-2012 data from the KNHANES. Two masked ophthalmologists evaluated fundus photography to detect RNFLDs. All participants underwent ocular and systemic evaluations...
2017: PloS One
https://www.readbyqxmd.com/read/28980561/-heidelberg-retinal-tomography-of-the-optic-disc-in-the-early-diagnosis-of-glaucoma
#18
V A Machekhin, O L Fabrikantov
AIM: To analyze anatomical and topographic optic disc parameters with account to the disc area in glaucoma suspects. MATERIAL AND METHODS: The study included 302 patients (408 eyes) aged 25 to 76 years (the mean age of 50.5±12.5 years); men and women roughly equal in number. The eyes were divided into 8 groups depending on the disc area, which ranged from 0.89 to 3.5 mm2. With HRT, 11 global and sector optic disc parameters were examined, 4 of which (disc area, rim area, cup/disc ratio, mean RNFL thickness) are presented in this paper...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28965293/pca-based-localization-approach-for-segmentation-of-optic-disc
#19
Varun P Gopi, M S Anjali, S Issac Niwas
PURPOSE: The optic disc is the origin of the optic nerve, where the axons of retinal ganglion cells join together. The size, shape and contour of optic disc are used for classification and identification of retinal diseases. Automatic detection of eye disease requires development of an efficient algorithm. This paper proposes an efficient method for optic disc segmentation and detection for the diagnosis of retinal diseases. METHODS: The methodology involves optic disc localization, blood vessel inpainting and optic disc segmentation...
September 30, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28957111/electron-beam-excited-photon-emission-from-monopole-modes-of-a-plasmonic-nano-disc
#20
Xianglong Miao, Kai Guo, Cheng Qian, Jin Wang, Degang Zhao, Kin Hung Fung
Plasmonic dark modes are not easy to be observed in the far field due to their weak photon emission. By contrast, it has been shown that a dark mode can be excited effectively by a near-field source such as an electron beam. In this Letter, we show theoretically that the photon emission from the monopole-like dark mode supported on a plasmonic nano-disc could be unexpectedly strong when excited by an electron beam through its hole. Even though this monopole mode is considered to be dark, it is found that the emission can be even "brighter" than the dipolar bright modes when the electron speed is higher than 0...
September 1, 2017: Optics Letters
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