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https://www.readbyqxmd.com/read/28823136/identification-of-polymorphisms-in-mitf-and-dct-genes-and-their-associations-with-plumage-colors-in-asian-duck-breeds
#1
Hasina Sultana, Dongwon Seo, Nu-Ri Choi, Md Shamsul Alam Bhuiyan, Seung Hwan Lee, Kang Nyeong Heo, Jun Heon Lee
Objective: The aim of this study was to investigate the effect of single nucleotide polymorphisms (SNPs) of the MITF and DCT genes on plumage coloration in Asian native duck breeds. MITF encodes a protein for microphthalmia-associated transcription factor, which regulates the development and function of melanocytes for pigmentation of skin, hair, and eyes. Among the tyrosinase-related family genes, dopachrome tautomerase (DCT) is a pigment cell-specific gene that plays important roles in the melanin synthesis pathway and the expression of skin, feather, and retina color...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28823106/mitochondrial-outer-membrane-permeabilization-a-focus-on-the-role-of-mitochondrial-membrane-structural-organization
#2
REVIEW
Siti Haji Suhaili, Hamed Karimian, Matthew Stellato, Tzong-Hsien Lee, Marie-Isabel Aguilar
Apoptosis is important in regulating cell death turnover and is mediated by the intrinsic and death receptor-based extrinsic pathways which converge at the mitochondrial outer membrane (MOM) leading to mitochondrial outer membrane permeabilization (MOMP). MOMP results in the release of apoptotic proteins that further activate the downstream pathway of apoptosis. Thus, tight regulation of MOMP is crucial in controlling apoptosis, and a lack of control may lead to tissue and organ malformation and the development of cancers...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28823102/the-etiology-of-primary-hyperhidrosis-a-systematic-review
#3
REVIEW
Moshe Hashmonai, Alan E P Cameron, Cliff P Connery, Noel Perin, Peter B Licht
PURPOSE: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. METHODS: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed...
August 19, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28823069/current-status-of-cattle-production-system-in-nyagatare-district-rwanda
#4
Eugene Mazimpaka, Francis Mbuza, Tukei Michael, Eugene N Gatari, E M Bukenya, Okwee-Acai James
A study was conducted to characterize the cattle production systems in Nyagatare District, Eastern Province of Rwanda using pre-tested questionnaires, interviews with key informants as well as focus group discussions in a period of 2 months. The respondents were selected by multi-stage sampling at sector and cell levels. Based on the procedure of Krejcie and Morgan (Educational and Psychological Measurement 30:607-610, 1970) to determine the overall sample size, the result indicated that the majority (98.3%) of farms were privately owned by large families of five to seven members, and most farmers (53...
August 19, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28822987/effects-of-a-water-extract-of-lepidium-meyenii-root-in-different-models-of-persistent-pain-in-rats
#5
Barbara Tenci, Lorenzo Di Cesare Mannelli, Mario Maresca, Laura Micheli, Giuseppe Pieraccini, Nadia Mulinacci, Carla Ghelardini
Lepidium meyenii (Walp.), commonly called maca, is an Andean crop belonging to the Brassicaceae family. Maca hypocotils are habitually consumed as customary food as well as traditional remedies for pathological conditions such as infertility. Moreover, the characterization of maca extracts revealed the presence of compounds that are able to modulate the nervous system. Aimed to evaluate the efficacy of L. meyenii in persistent pain, the present study analyzed the effects of a commercial root extract from maca in different animal models reproducing the most common causes of chronic painful pathologies...
August 21, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28822973/pai-1-levels-are-related-to-insulin-resistance-and-carotid-atherosclerosis-in-subjects-with-familial-combined-hyperlipidemia
#6
Arturo Carratala, Sergio Martinez-Hervas, Enrique Rodriguez-Borja, Esther Benito, José T Real, Guillermo T Saez, Rafael Carmena, Juan F Ascaso
Familial combined hyperlipidemia (FCH) is a primary atherogenic dyslipidemia with insulin resistance and increased cardiovascular risk. Plasminogen activator inhibitor type 1 (PAI-1) and myeloperoxidase (MPO) activity are associated with proinflammatory and atherothrombotic risk. Our aim was to study the role played by PAI-1 and MPO activity in the carotid atherosclerosis prevalence in FCH subjects. 36 FCH unrelated subjects (17 women) were matched by age and body weight with 36 healthy normolipidemic subjects (19 female)...
August 19, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28822971/second-hand-smoke-exposure-in-homes-with-children-assessment-of-airborne-nicotine-in-the-living-room-and-children-s-bedroom
#7
Teresa Arechavala, Xavier Continente, Mónica Pérez-Ríos, Anna Schiaffino, Esteve Fernandez, Núria Cortés-Francisco, Francesc Centrich, Glòria Muñoz, Maria J López
BACKGROUND: The introduction of 'smoke-free laws' has reduced the population's exposure to second-hand smoke (SHS), although SHS is still an issue in homes and other public places. Children are vulnerable to its health effects, and their greatest exposure occurs at home. OBJECTIVES: To assess airborne nicotine concentration of the living room and children's bedroom of homes with children under 13 years of age, and to analyse factors associated with these levels...
August 19, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28822916/wip1-dependent-modulation-of-macrophage-migration-and-phagocytosis
#8
Yiting Tang, Bing Pan, Xin Zhou, Kai Xiong, Qian Gao, Lei Huang, Ying Xia, Ming Shen, Shulin Yang, Honglin Liu, Tao Tan, Jianjie Ma, Xuehong Xu, Yulian Mu, Kui Li
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains a major challenge for treatment of atherosclerotic diseases. Here, we show that Wip1, a member of the PP2C family of Ser/Thr protein phosphatases, modulates macrophage migration and phagocytosis associated with atherosclerotic plaque formation. Wip1 deficiency increases migratory and phagocytic activities of the macrophage under stress conditions. Enhanced migration of Wip1(-/-) macrophages is mediated by Rac1-GTPase and PI3K/AKT signalling pathways...
August 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28822909/variation-in-basal-body-localisation-and-targeting-of-trypanosome-rp2-and-for20-proteins
#9
Jane Harmer, Xin Qi, Gabriella Toniolo, Aysha Patel, Hannah Shaw, Fiona E Benson, Michael L Ginger, Paul G McKean
TOF-LisH-PLL motifs define FOP family proteins; some members are involved in flagellum assembly. The critical role of FOP family protein FOR20 is poorly understood. Here, we report relative localisations of the four FOP family proteins in parasitic Trypanosoma brucei: TbRP2, TbOFD1 and TbFOP/FOP1-like are mature basal body proteins whereas TbFOR20 is present on pro- and mature basal bodies - on the latter it localises distal to TbRP2. We discuss how the data, together with published work for another protist Giardia intestinalis, informs on likely FOR20 function...
July 13, 2017: Protist
https://www.readbyqxmd.com/read/28822891/comparative-toxicity-of-the-plasticizer-dibutyl-phthalate-to-two-freshwater-algae
#10
Shurui Gu, Hao Zheng, Qingqing Xu, Cuizhu Sun, Mei Shi, Zhenyu Wang, Fengmin Li
Phthalate esters (PAEs), a family of emerging environmental contaminants, have been frequently detected in soils and water. However, intensive studies on the toxicity of PAEs have focused on growth response of terrestrial and aquatic animals, while only limited attention has been paid to aquatic plants, especially phytoplankton, the primary producer in aquatic ecosystems. Therefore, the acute toxic effects and underlying mechanisms of dibutyl phthalate (DBP) at different concentrations (0-20mgL(-1)) on two typical freshwater algae (Scenedesmus obliquus and Chlorella pyrenoidosa) were investigated...
August 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28822857/exploring-associations-of-clinical-and-social-parameters-with-violent-behaviors-among-psychiatric-patients
#11
Hong-Jie Dai, Emily Chia-Yu Su, Mohy Uddin, Jitendra Jonnagaddala, Chi-Shin Wu, Shabbir Syed-Abdul
Evidence has revealed interesting associations of clinical and social parameters with violent behaviors of patients with psychiatric disorders. Men are more violent preceding and during hospitalization, whereas women are more violent than men throughout the 3 days following a hospital admission. It has also been proven that mental disorders may be a consistent risk factor for the occurrence of violence. In order to better understand violent behaviors of patients with psychiatric disorders, it is important to investigate both the clinical symptoms and psychosocial factors that accompany violence in these patients...
August 16, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28822851/-why-are-we-not-doing-more-for-them-genocide-prevention-lessons-from-the-kindertransport
#12
J Angel, D P Evans
OBJECTIVES: Genocide remains one of the most widespread forms of preventable mortality and morbidity for children today. Despite the creation of multiple human rights treaties, genocide has not been eliminated and its effects disproportionally impact children. The Kindertransport was a series of rescue efforts that brought thousands of refugee children to the United Kingdom from Nazi Germany between 1938 and 1940. This qualitative study asks what public health professionals can learn from the prevention efforts of the Kindertransport by examining the experiences and reflections of individuals rescued as children...
August 17, 2017: Public Health
https://www.readbyqxmd.com/read/28822850/an-assessment-of-food-safety-information-provision-for-uk-chemotherapy-patients-to-reduce-the-risk-of-foodborne-infection
#13
E W Evans, E C Redmond
OBJECTIVES: Given the increased risk of foodborne infection to cancer patients receiving chemotherapy treatment, and the risk of listeriosis reportedly five-times greater to this immunocompromised patient group, there is a need to ensure the implementation of domestic food safety practices among chemotherapy patients and their family caregivers. However, information regarding the adequacy of resources to inform and enable patients to implement domestic food safety practices to reduce the risk of foodborne infection is limited...
August 17, 2017: Public Health
https://www.readbyqxmd.com/read/28822827/host-genes-regulate-transcription-of-sperm-introduced-hepatitis-b-virus-genes-in-embryo
#14
Ying Zhong, Dong-Ling Liu, Mohamed Morsi M Ahmed, Peng-Hao Li, Xiao-Ling Zhou, Qing-Dong Xie, Xiao-Qing Xu, Ting-Ting Han, Zhi-Wei Hou, Chen-Yao Zhong, Ji-Hua Huang, Fei Zeng, Tian-Hua Huang
Hepatitis B virus (HBV) can invade the male germline, and sperm-introduced HBV genes could be transcribed in embryo. This study was to explore whether viral gene transcription is regulated by host genes. Embryos were produced by in vitro fertilization of hamster oocytes with human sperm containing the HBV genome. Total RNA extracted from test and control embryos were subjected to SMART-PCR, SSH, microarray hybridization, sequencing and BLAST analysis. Twenty-nine sequences showing significant identity to five human gene families were identified, with CSH2, EIF4G2, PCBD2, PSG4 and TTN selected to represent target genes...
August 16, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28822785/next-generation-sequencing-based-detection-of-germline-copy-number-variations-in-brca1-brca2-validation-of-a-one-step-diagnostic-work-flow
#15
Ane Y Schmidt, Thomas V O Hansen, Lise B Ahlborn, Lars Jønson, Christina W Yde, Finn C Nielsen
Genetic testing of BRCA1/2 includes screening for single nucleotide variants and small indels as well as larger copy number variations (CNVs), primarily by Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA). With the advent of next-generation sequencing (NGS), it has become feasible to provide CNV information as well as sequence data using a single platform. We report the use of NGS gene panel sequencing on the Illumina MiSeq platform and JSI SeqPilot SeqNext software to call germline CNVs in BRCA1 and BRCA2...
August 16, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28822781/inpatient-versus-outpatient-parenteral-antibiotic-therapy-at-home-for-acute-infections-in-children-a-systematic-review
#16
REVIEW
Penelope A Bryant, Naomi T Katz
Inpatient management is necessary in many situations, but medical and allied-health treatments are increasingly being used on an outpatient basis to allow patients who would traditionally have been admitted to hospital to remain at home. Home-based clinical management has many potential benefits, including reduced hospital-acquired infections, cost savings, and patient and family satisfaction. Studies in adults provide evidence for the benefits of home-based versus hospital-based intravenous antibiotics, but few studies inform practice in home-based intravenous antibiotic therapy for children...
August 16, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28822712/socioeconomic-inequality-in-childhood-obesity-and-its-determinants-in-iran-a-blinder-oaxaca-decomposition
#17
Roya Kelishadi, Mostafa Qorbani, Ramin Heshmat, Shirin Djalalinia, Ali Sheidaei, Saeid Safiri, Nastaran Hajizadeh, Mohammad Esmaeil Motlagh, Gelayol Ardalan, Hamid Asayesh, Morteza Mansourian
OBJECTIVE: Childhood obesity has become a priority health concern worldwide. Socioeconomic status (SES) is one of its main determinants. This study aimed to assess the socioeconomic inequality of obesity in children and adolescents at national and provincial levels in Iran. METHODS: This multicenter cross-sectional study was conducted in 2011-2012, as part of a national school-based surveillance program performed in 40,000 students, aged 6-18-years, from urban and rural areas of 30 provinces of Iran...
August 17, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28822393/identifying-futile-interfacility-surgical-transfers
#18
Kristy Kummerow Broman, Sharon E Phillips, Jesse M Ehrenfeld, Mayur B Patel, Oscar M Guillamondegui, Kenneth W Sharp, Richard A Pierce, Benjamin K Poulose, Michael D Holzman
Surgeons perceive that some surgical transfers are futile, but the incidence and risk factors of futile transfer are not quantified. Identifying futile interfacility transfers could save cost and undue burdens to patients and families. We sought to describe the incidence and factors associated with futile transfers. We conducted a retrospective cohort study from 2009 to 2013 including patients transferred to a tertiary referral center for general or vascular surgical care. Futile transfers were defined as resulting in death or hospice discharge within 72 hours of transfer without operative, endoscopic, or radiologic intervention...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822352/vibrio-vulnificus-martx-cytotoxin-causes-inactivation-of-phagocytosis-related-signaling-molecules-in-macrophages
#19
Chun-Liang Chen, Shu-Chun Chien, Tzeng-Horng Leu, Hans I-Chen Harn, Ming-Jer Tang, Lien-I Hor
BACKGROUND: Vibrio vulnificus is a marine bacterial species that causes opportunistic infections manifested by serious skin lesions and fulminant septicemia in humans. We have previously shown that the multifunctional autoprocessing repeats in toxin (MARTXVv1) of a biotype 1 V. vulnificus strain promotes survival of this organism in the host by preventing it from engulfment by the phagocytes. The purpose of this study was to further explore how MARTXVv1 inhibits phagocytosis of this microorganism by the macrophage...
August 19, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28822253/clout-or-doubt-perspectives-on-an-infant-mental-health-service-for-young-children-placed-in-foster-care-due-to-abuse-and-neglect
#20
Fiona Turner-Halliday, Gary Kainth, Genevieve Young-Southward, Richard Cotmore, Nicholas Watson, Lynn McMahon, Helen Minnis
Despite knowledge about the profound effects of child abuse and neglect, we know little about how best to assess whether maltreated children should return home. The effectiveness of the New Orleans Intervention Model (NIM) is being tested in a randomized controlled trial where the comparison is social work 'services as usual.' The future trial results will tell us which approach produces the best outcomes for children; meanwhile qualitative process evaluation is generating intriguing findings about the perceived impact of NIM on decision-making about childrens' futures...
August 16, 2017: Child Abuse & Neglect
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