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https://www.readbyqxmd.com/read/29046009/-experiences-of-patients-with-invasive-and-non-invasive-home-mechanical-ventilation-a-systematic-review-of-qualitative-research
#1
V Nelißen, S Metzing, W Schnepp
Aim of the study Human beings can be ventilated outside of a hospital after a lung failure or due to a neurodegenerative disease. This can be done in different living conditions. This article examines the question of what experiences such patients have made with invasive home mechanical ventilation, and how they have adapted their new lives. Methodology On the basis of a systematic literature research, qualitative studies were analyzed that depict the social reality of patients with invasive and non-invasive home mechanical ventilation...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/29045990/electronic-health-record-impacts-on-family-medicine-teachers-survey-of-third-year-medical-student-clerkship-preceptors-at-an-academic-medical-center
#2
Elizabeth Curry, Tamara K Oser, Sean M Oser
BACKGROUND AND OBJECTIVES: Electronic Health Record (EHR) use in clinical practice has accelerated in recent years. While several aspects of EHR use have been extensively studied, there is little data on EHR impacts on medical student educators, especially those involved in outpatient family medicine. This study evaluated perceived impacts of EHR use on clinician teachers of outpatient family medicine. METHODS: The study used a mixed methods survey of clinicians who teach third-year medical students during the required family and community medicine outpatient clerkship at a Mid-Atlantic medical school...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045989/human-papillomavirus-vaccination-training-experience-among-family-medicine-residents-and-faculty
#3
Monica L Kasting, Courtney L Scherr, Karla N Ali, Paige Lake, Teri L Malo, Tracy Johns, Richard G Roetzheim, Gwendolyn P Quinn, Susan T Vadaparampil
BACKGROUND AND OBJECTIVES: Residency training is a pivotal time to establish skills for career-long practices, particularly for challenging skills such as human papillomavirus (HPV) vaccine recommendation. Training experience and preferences related to delivering HPV vaccine recommendations were examined for family medicine (FM) residents and faculty. METHODS: Residents (n=28) and faculty (n=19) were identified through a national FM residency directory and recruited from training programs in Florida...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045987/perspectives-of-family-medicine-clerkship-directors-regarding-forward-feeding-a-cera-study
#4
Lisa D Mims, Alexei O DeCastro, Ann G Kelly
BACKGROUND AND OBJECTIVES: Forward feeding signifies sharing information about learners for purposes of professional and academic advancement, and promotes progression toward a competency-based educational continuum. The aim of this study is to assess reasons for difficulty or failure of the family medicine clerkship and investigate utilization and methods of forward feeding. Reasons behind medical school policies regarding forward feeding are also evaluated. METHODS: Data were collected through the 2013 Council of Academic Family Medicine (CAFM) Educational Research Alliance (CERA) Family Medicine Clerkship Director survey...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045986/impact-of-residency-training-redesign-on-residents-clinical-knowledge
#5
Elaine Waller, M Patrice Eiff, Eve Dexter, Jason C B Rinaldo, Miguel Marino, Roger Garvin, Alan B Douglass, Robert Phillips, Larry A Green, Patricia A Carney
BACKGROUND AND OBJECTIVES: The In-training Examination (ITE) is a frequently used method to evaluate family medicine residents' clinical knowledge. We compared family medicine ITE scores among residents who trained in the 14 programs that participated in the Preparing the Personal Physician for Practice (P4) Project to national averages over time, and according to educational innovations. METHODS: The ITE scores of 802 consenting P4 residents who trained in 2007 through 2011 were obtained from the American Board of Family Medicine...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29045887/polymorphism-intermolecular-interactions-and-spectroscopic-properties-in-crystal-structures-of-sulfonamides
#6
C Ignacio Sainz-Díaz, Misaela Francisco-Márquez, Catalina Soriano-Correa
The antibiotics family of sulfonamides has been used worldwide intensively in human therapeutics and farm livestock during decades. Intermolecular interactions of these sulfamides are important to understand their bioactivity and biodegradation. These interactions are also responsible for their supramolecular structures. The intermolecular interactions in the crystal polymorphs of the sulfonamides, sulfamethoxypyridazine and sulfamethoxydiazine, as models of sulfonamides, have been studied by using quantum mechanical calculations...
October 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29045866/how-many-protein-sequences-fold-to-a-given-structure-a-coevolutionary-analysis
#7
Pengfei Tian, Robert B Best
Quantifying the relationship between protein sequence and structure is key to understanding the protein universe. A fundamental measure of this relationship is the total number of amino acid sequences that can fold to a target protein structure, known as the "sequence capacity," which has been suggested as a proxy for how designable a given protein fold is. Although sequence capacity has been extensively studied using lattice models and theory, numerical estimates for real protein structures are currently lacking...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045862/the-two-state-prehensile-tail-of-the-antibacterial-toxin-colicin-n
#8
Christopher L Johnson, Alexandra S Solovyova, Olli Hecht, Colin Macdonald, Helen Waller, J Günter Grossmann, Geoffrey R Moore, Jeremy H Lakey
Intrinsically disordered regions within proteins are critical elements in many biomolecular interactions and signaling pathways. Antibacterial toxins of the colicin family, which could provide new antibiotic functions against resistant bacteria, contain disordered N-terminal translocation domains (T-domains) that are essential for receptor binding and the penetration of the Escherichia coli outer membrane. Here we investigate the conformational behavior of the T-domain of colicin N (ColN-T) to understand why such domains are widespread in toxins that target Gram-negative bacteria...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045859/role-of-condensing-particles-in-polymer-confinement-a-model-for-virus-packed-minichromosomes
#9
Sanjin Marion, Carmen San Martín, Antonio Šiber
Confined mixtures of a polymer and nonspecifically binding particles (condensers) are studied as models for viruses containing double-stranded DNA (polymer) and condensing proteins (particles). We explore a model in which all interactions between the packed content (polymer and particles) and its confinement are purely repulsive, with only a short-range attraction between the condensers and polymer to simulate binding. In the range of physical parameters applicable to viruses, the model predicts reduction of pressure in the system effected by the condensers, despite the reduction in free volume...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045760/biological-imaging-with-medium-sensitive-bichromatic-flexible-fluorescent-flexfluor-dyes
#10
Yang Cao, Xiaozhu Wang, Xiaolei Shi, Suzanne M Clee, Patrick L McGeer, Michael O Wolf, Chris Orvig
A new family of environment-sensitive shape-shifting molecules have been developed as flexible fluorescent (FlexFluor) dyes for biological imaging applications. These compounds feature a flexible bithiophene-based fluorophore that gives rise to different emission colors in lipophilic or hydrophilic environments, as well as side-groups that can be easily synthetically modified. As the first fluorescent dyes in which emission color can be used to indicate lipid/water environments, the behavior of FlexFluor dyes in different solvents has been studied, and used to simultaneously highlight lipid and water contents in adipose and brain tissues using optical fluorescence microscopy...
October 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29045753/association-between-the-rs1229984-polymorphism-in-the-alcohol-dehydrogenase-b-adh1b-gene-and-risk-for-restless-legs-syndrome
#11
Félix Javier Jiménez-Jiménez, Javier Gómez-Tabales, Hortensia Alonso-Navarro, Martín Zurdo, Laura Turpín-Fenoll, Jorge Millán-Pascual, Teresa Adeva-Bartolomé, Esther Cubo, Francisco Navacerrada, Ana Rojo-Sebastián, Lluisa Rubio, Mónica Díez-Fairén, Pau Pastor, Marisol Calleja, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente, Margarita Arroyo-Solera, Esteban García-Albea, José A G Agúndez, Elena García-Martín
Background/Objective: Several studies have raised the possibility of an association between alcohol consumption and the risk of developing restless legs syndrome (RLS). Moreover, an important percentage of patients under alcohol detoxification therapy develop RLS symptoms fulfil the criteria for idiopathic RLS during alcohol withdrawal. We have aimed to establish the possible association between 2 common single nucleotide polymorphisms (SNPs) in the alcohol-dehydrogenase 1B (ADH1B) gene, and the risk for RLS...
October 16, 2017: Sleep
https://www.readbyqxmd.com/read/29045622/international-exchanges-in-primary-care-learning-from-thy-neighbour
#12
Bernadeta Bridgwood, John Park, Claire Hawcroft, Natasha Kay, Eugene Tang
This systematic review describes how international exchange programmes in primary care have been received and evaluated. Electronic databases (MEDLINE, Embase, PsycINFO, EBM reviews, CAB abstracts and PubMED) were searched to identify articles where the main focus of the study was exchanges undertaken in primary care/family medicine until March 2016. Articles were included if they (i) discussed participant exchanges in primary care; (ii) presented associated outcome data-this included (a) individual/group experience of exchange; (b) mechanism of exchange and (c) observations during the exchange...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29045571/zinc-induced-metallothionein-in-centenarian-offspring-from-a-large-european-population-the-mark-age-project
#13
Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Alexander Bürkle, Maria Moreno-Villanueva, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Claudio Franceschi, Antti Hervonen, Eline Slagboom, Fabio Ciccarone, Michele Zampieri, Paola Caiafa, Eugène Jansen, Martijn E T Dollé, Nicolle Breusing, Eugenio Mocchegiani, Marco Malavolta
Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO)...
October 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29045487/the-psychosocial-impact-of-leg-ulcers-in-patients-with-sickle-cell-disease-i-don-t-want-them-to-know-my-little-secret
#14
Nkeiruka I Umeh, Brittany Ajegba, Ashley J Buscetta, Khadijah E Abdallah, Caterina P Minniti, Vence L Bonham
BACKGROUND: Sickle cell disease (SCD) impacts millions of individuals worldwide and more than 100,000 people in the United States. Leg ulcers are the most common cutaneous manifestation of SCD. The health status of individuals living with chronic leg ulcers is not only influenced by clinical manifestations such as pain duration and intensity, but also by psychosocial factors. Garnering insights into the psychosocial impact can provide a more holistic view of their influence on quality of life...
2017: PloS One
https://www.readbyqxmd.com/read/29045473/identification-of-functionally-important-micrornas-from-rice-inflorescence-at-heading-stage-of-a-qdty4-1-qtl-bearing-near-isogenic-line-under-drought-conditions
#15
Boon Huat Cheah, Sudhir Jadhao, Madavan Vasudevan, Ratnam Wickneswari, Kalaivani Nadarajah
A cross between IR64 (high-yielding but drought-susceptible) and Aday Sel (drought-tolerant) rice cultivars yielded a stable line with enhanced grain yield under drought screening field trials at International Rice Research Institute. The major effect qDTY4.1 drought tolerance and yield QTL was detected in the IR77298-14-1-2-10 Backcrossed Inbred Line (BIL) and its IR87705-7-15-B Near Isogenic Line (NIL) with 93.9% genetic similarity to IR64. Although rice yield is extremely susceptible to water stress at reproductive stage, currently, there is only one report on the detection of drought-responsive microRNAs in inflorescence tissue of a Japonica rice line...
2017: PloS One
https://www.readbyqxmd.com/read/29045471/parental-and-offspring-contribution-of-genetic-markers-of-adult-blood-pressure-in-early-life-the-family-study
#16
Sébastien Robiou-du-Pont, Sonia S Anand, Katherine M Morrison, Sarah D McDonald, Stephanie A Atkinson, Koon K Teo, David Meyre
Previous genome wide association studies (GWAS) identified associations of multiple common variants with diastolic and systolic blood pressure traits in adults. However, the contribution of these loci to variations of blood pressure in early life is unclear. We assessed the child and parental contributions of 33 GWAS single-nucleotide polymorphisms (SNPs) for blood pressure in 1,525 participants (515 children, 406 mothers and 237 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) study followed-up for 5 years...
2017: PloS One
https://www.readbyqxmd.com/read/29045440/parental-depressive-symptoms-children-s-emotional-and-behavioural-problems-and-parents-expressed-emotion-critical-and-positive-comments
#17
Lamprini Psychogiou, Nicholas J Moberly, Elizabeth Parry, Selina Nath, Angeliki Kallitsoglou, Ginny Russell
This longitudinal study examined whether mothers' and fathers' depressive symptoms predict, independently and interactively, children's emotional and behavioural problems. It also examined bi-directional associations between parents' expressed emotion constituents (parents' child-directed positive and critical comments) and children's emotional and behavioural problems. At time 1, the sample consisted of 160 families in which 50 mothers and 40 fathers had depression according to the Structured Clinical Interview for DSM-IV...
2017: PloS One
https://www.readbyqxmd.com/read/29045434/opportunities-challenges-and-systems-requirements-for-developing-post-abortion-family-planning-services-perceptions-of-service-stakeholders-in-china
#18
Hong Jiang, Jieshuang Xu, Esther Richards, Xu Qian, Weihong Zhang, Lina Hu, Shangchun Wu, Rachel Tolhurst
Post-abortion family planning (PAFP) has been proposed as a key strategy to decrease unintended pregnancy and repeat induced abortions. However, the accessibility and quality of PAFP services remain a challenge in many countries including China where more than 10 million unintended pregnancies occur each year. Most of these unwanted pregnancies end in repeated induced abortions. This paper aims to explore service providers' perceptions of the current situation regarding family planning and abortion service needs, provision, utilization, and the feasibility and acceptability of high quality PAFP in the future...
2017: PloS One
https://www.readbyqxmd.com/read/29045349/male-specific-association-between-fat-free-mass-index-and-faecal-microbiota-in-2-to-3-year-old-australian-children
#19
Paula Smith-Brown, Mark Morrison, Lutz Krause, Peter S W Davies
OBJECTIVES: Maturation of the gut microbiota has been shown to influence childhood growth while alterations in microbiota composition are proposed to be causally related to the development of overweight and obesity. The objective of this study is to explore the association between microbiota profile, body size and body composition in young children. METHODS: Faecal microbiota was examined by 16S rRNA gene sequencing while body composition was assessed using the deuterium oxide dilution technique in a cohort of 37 well-nourished 2 to 3 year old Australian children...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29045322/longitudinal-associations-between-physical-activity-and-educational-outcomes
#20
Jaana T Kari, Jaakko Pehkonen, Nina Hutri-Kähönen, Olli T Raitakari, Tuija H Tammelin
PURPOSE: This longitudinal study examined the role of leisure-time physical activity in academic achievement at the end of compulsory basic education and educational attainment in adulthood. METHODS: The data were drawn from the ongoing longitudinal Cardiovascular Risk in Young Finns Study, which was combined with register-based data from Statistics Finland. The study consisted of children who were 12 yr (n = 1723, 49% boys) and 15 yr (n = 2445, 48% boys) of age at the time when physical activity was measured...
November 2017: Medicine and Science in Sports and Exercise
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