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https://www.readbyqxmd.com/read/29694979/promotion-of-tumor-growth-by-adamts4-in-colorectal-cancer-focused-on-macrophages
#1
Jianjun Chen, Yang Luo, Yong Zhou, Shaolan Qin, Yier Qiu, Ran Cui, Minhao Yu, Jun Qin, Ming Zhong
BACKGROUND/AIMS: ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions. The aim of the present study was to investigate: 1) the mutation, copy-number alterations, and expression profile of ADAMTSs in colorectal cancer and 2) whether ADAMTSs participate in colorectal cancer (CRC) progression and invasion. METHODS: The mutation, copy-number alterations, and expression profile of ADAMTSs in CRC were analyzed in the TCGA cohort using cBioportal...
April 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29694886/multiplexed-quantitation-of-intraphagocyte-mycobacterium-tuberculosis-secreted-protein-effectors
#2
Fadel Sayes, Catherine Blanc, Louis S Ates, Nathalie Deboosere, Mickael Orgeur, Fabien Le Chevalier, Matthias I Gröschel, Wafa Frigui, Ok-Ryul Song, Richard Lo-Man, Florence Brossier, Wladimir Sougakoff, Daria Bottai, Priscille Brodin, Pierre Charneau, Roland Brosch, Laleh Majlessi
The pathogenic potential of Mycobacterium tuberculosis largely depends on ESX secretion systems exporting members of the multigenic Esx, Esp, and PE/PPE protein families. To study the secretion and regulation patterns of these proteins while circumventing immune cross-reactions due to their extensive sequence homologies, we developed an approach that relies on the recognition of their MHC class II epitopes by highly discriminative T cell receptors (TCRs) of a panel of T cell hybridomas. The latter were engineered so that each expresses a unique fluorescent reporter linked to specific antigen recognition...
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29694709/identification-of-n-acyl-homoserine-lactone-degrading-bacteria-isolated-from-rainbow-trout-oncorhynchus-mykiss
#3
Somayeh Torabi Delshad, Siyavash Soltanian, Hassan Sharifiyazdi, Masoud Haghkhah, Peter Bossier
AIMS: A variety of pathogens use quorum sensing (QS) to control the expression of their virulence factors. QS interference has hence been proposed as a promising anti-virulence strategy. The specific aim of this study was to isolate bacteria from trout tissue able to degrade N-Acyl Homoserine Lactones (AHL), a QS molecule family. METHODS AND RESULTS: In total 132 isolates were screened for AHL degradation using Chromobacterium violaceum CV026 as a biosensor. Twenty four quorum quenching (QQ) isolates were identified biochemically and characterized using 16S rDNA sequencing...
April 25, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29694607/clinical-and-laboratory-characteristics-associated-with-referral-of-hospitalized-elderly-to-palliative-care
#4
Suelen Pereira Arcanjo, Luis Alberto Saporetti, José Antonio Esper Curiati, Wilson Jacob-Filho, Thiago Junqueira Avelino-Silva
Objective To investigate clinical and laboratory characteristics associated with referral of acutely ill older adults to exclusive palliative care. Methods A retrospective cohort study based on 572 admissions of acutely ill patients aged 60 years or over to a university hospital located in São Paulo, Brazil, from 2009 to 2013. The primary outcome was the clinical indication for exclusive palliative care. Comprehensive geriatric assessments were used to measure target predictors, such as sociodemographic, clinical, cognitive, functional and laboratory data...
2018: Einstein
https://www.readbyqxmd.com/read/29694606/cardiovascular-abnormalities-in-patients-with-oral-cleft-a-clinical-electrocardiographic-echocardiographic-study
#5
Gisele C P Leite, Marcela A G Ururahy, João F Bezerra, Valéria M G D M Lima, Maria I F Costa, Sandra S C Freire, André D Luchessi, Jussara M C Maia, Maria E F Brito, Vera L Gil-da-Silva-Lopes, Adriana A Rezende
OBJECTIVES: The present study aims to describe the clinical, electrocardiographic, and echocardiographic cardiological findings in a group of patients with oral clefts. METHODS: This is a prospective cross-sectional study on 70 children (age range from 13 days to 19 years) with oral clefts who attended the multidisciplinary program of a university hospital from March 2013 to September 2014. The patients were evaluated by a pediatric cardiologist and underwent detailed anamnesis, physical examination, electrocardiogram, and echocardiogram...
2018: Clinics
https://www.readbyqxmd.com/read/29694601/distribution-and-risk-factors-of-ascarididae-and-other-geohelminths-in-the-soil-of-uberlandia-minas-gerais-brazil
#6
Kelem Cristina Pereira Mota, Daliane Faria Grama, Natália M Nasser Fava, Letícia Pereira Úngari, Elaine Silva Marques Faria, Márcia Cristina Cury
Among the geohelminths, parasites from the Ascarididae family have a significant role in the human and animal health. This research aims to determine the prevalence of Ascarididae species in the soil in different areas located in a city of Minas Gerais State, Brazil (South America). The study was developed in squares, parks, sports clubs, orchards and municipal children's schools. Samples of sand/soil/grass were collected from January to August 2014. The optical microscope screening was performed through formal-ether and spontaneous sedimentation techniques...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29694599/-circumstances-and-consequences-of-care-characterization-of-the-family-caregiver-in-palliative-care
#7
Mayra Delalibera, António Barbosa, Isabel Leal
Family caregivers play an important role in advanced disease patient care. The goal of this study was to characterize the family caregiver in palliative care, evaluating the circumstances and consequences of care and preparation for the loss of the loved one. This is a quantitative, prospective and longitudinal study. The sample consisted of 60 family caregivers, mostly women, married with an average age of 44.53 years. Most caregivers cohabit with the patient, and they spend the greater part of their day caring for the patient and a significant part quit their jobs or reduce working hours to be with the patient...
April 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29694597/-pregnancy-and-abortion-experience-among-children-adolescents-and-youths-living-on-the-streets
#8
Lucas Neiva-Silva, Lauro Miranda Demenech, Laísa Rodrigues Moreira, Adriano Trassantes Oliveira, Fernanda Torres de Carvalho, Simone Dos Santos Paludo
The aim of this study is to identify the prevalence of pregnancy and abortion experience, along with associated factors among street children, adolescents and youths in Porto Alegre and Rio Grande, RS, Brazil. The sampling method in this cross-sectional study was Respondent-Driven Sampling (RDS), innovative in research about hidden populations. Interviews were conducted with 307 subjects, aged 10 to 21 years. In multivariate analysis, Poisson regression with a robust error variance was used. Most of this sample were males, with no contact with school and family...
April 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29694584/-factors-associated-with-the-need-for-oral-treatment-of-elderly-brazilians-a-multilevel-analysis
#9
Chaiane Emilia Dalazen, Alessandro Diogo De Carli, Rafael Aiello Bomfim
The aims of this study were to estimate the prevalence of prosthetic requirements and dental treatment needs among the elderly Brazilian population and the associations with contextual and individual determinants. Data were taken from the Brazilian Oral Health Survey (SB Brasil 2010) and a sample of 7,619 Brazilian people aged 65-74 years were investigated. Multilevel logistic regression models were used to estimate the odds ratio (OR) and 95% confidence intervals between treatment needs and contextual variables (Municipal Human Development Index, Gini coefficient and oral health coverage in the Family Health Strategy) and individual (gender, income, education and skin color)...
April 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29694582/-satisfaction-with-care-received-in-pediatric-emergency-services-impact-of-family-interaction-and-emotional-disturbance
#10
Antonio Fernández-Castillo, María J Vílchez-Lara
This study addresses the relationship between two key elements in satisfaction with pediatric emergency services, namely emotional disturbance and family interaction. The main goal is to determine whether family cohesion and adaptability and anger may be associated with differential levels of satisfaction among parents whose children were attended in pediatric emergency units. It is a descriptive study for which a sample of 711 parents whose children were attended in 6 pediatric emergency services was studied...
April 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29694578/-trajectory-in-narratives-experiences-of-mental-illness-and-the-city-of-belo-horizonte
#11
Amanda Elias Arruda, Ana Lúcia Modesto, Cláudio Santiago Dias Júnior
The article seeks to understand the relationships established between mentally ill patients cared for in the open community service network and the city of Belo Horizonte, state capital of Minas Gerais. It is understood that the experience of mental illness is capable of generating narratives that seek to give meaning to suffering and help people to negotiate everyday decisions. The biographical method was used for the construction of narratives of life trajectories of the three participants of the study. The biographical narratives revealed diverse experiences associated with mental illness as well as different meanings attributed to this condition...
April 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29694558/traditional-knowledge-and-uses-of-medicinal-plants-by-the-inhabitants-of-the-islands-of-the-s%C3%A3-o-francisco-river-brazil-and-preliminary-analysis-of-rhaphiodon-echinus-lamiaceae
#12
I D S L Pio, A L Lavor, C M D Damasceno, P M N Menezes, F S Silva, G L A Maia
This study aimed to carry out an ethnobotanical survey of medicinal plants used by inhabitants of the Rodeadouro Island, Jatoba Island and Massangano Island, located in The Submedium São Francisco River Valley. Also phytochemicals and preliminary pharmacological tests were performed to species most cited by the community. Ethnobotanical data were collected through observation visits and semi-structured interviews with 12 key informants. We calculated the relative importance (RI), the percentage of agreement related to the main uses (cAMU) and use value (UV)...
April 19, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29694494/asilidae-diptera-of-two-atlantic-forest-protected-areas-of-rio-de-janeiro-southeastern-brazil
#13
Danilo P Moreira-Junior, Valéria C Maia
As few Asilidae inventories of Rio de Janeiro areas have been published, there are many data gaps. This paper aims to contribute to the knowledge of richness, abundance and distribution of this family in this State. From January 2013 to March 2014, insects were collected monthly using Malaise traps and every two months using entomological nets in the Reserva Biológica União (REBIO), and Estação Ecológica Estadual de Guaxindiba (EEEG). 682 specimens of Asilidae were collected in the present study, distributed in 31 genera and 51 species (20 identified and 31 unidentified), 527 of REBIO (in 19 genera and 38 species - 14 identified and 24 unidentified), and 155 specimens of EEEG (in 12 genera and 19 species - 6 identified and 13 unidentified)...
April 23, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29694438/-that-s-what-you-do-for-people-you-love-a-qualitative-study-of-social-support-and-recovery-from-a-musculoskeletal-injury
#14
Khic-Houy Prang, Sharon Newnam, Janneke Berecki-Gisolf
BACKGROUND: Social support has been identified as a significant factor in facilitating better health outcomes following injury. However, research has primarily focused on the role of social support from the perspective of the person experiencing an injury. Limited research has examined the experiences of the family members and friends of a person with injury. This study aims to explore the perceptions and experiences of social support and recovery following a transport-related musculoskeletal injury (MSI) in a population of injured persons and their family members and friends...
2018: PloS One
https://www.readbyqxmd.com/read/29694416/the-chloroplast-genome-sequence-of-bittersweet-solanum-dulcamara-plastid-genome-structure-evolution-in-solanaceae
#15
Ali Amiryousefi, Jaakko Hyvönen, Péter Poczai
Bittersweet (Solanum dulcamara) is a native Old World member of the nightshade family. This European diploid species can be found from marshlands to high mountainous regions and it is a common weed that serves as an alternative host and source of resistance genes against plant pathogens such as late blight (Phytophthora infestans). We sequenced the complete chloroplast genome of bittersweet, which is 155,580 bp in length and it is characterized by a typical quadripartite structure composed of a large (85,901 bp) and small (18,449 bp) single-copy region interspersed by two identical inverted repeats (25,615 bp)...
2018: PloS One
https://www.readbyqxmd.com/read/29694324/do-cooperative-learning-and-family-involvement-improve-variables-linked-to-academic-performance
#16
Miguel A Santos Rego, María J Ferraces Otero, Agustín Godas Otero, María M Lorenzo Moledo
BACKGROUND: One of the most serious problems in the Spanish education system is the high percentage of school failure in Compulsory Secondary Education. The aim of this study is to analyze the influence of a socio-educational program based on cooperative learning and family involvement on a series of variables related to academic performance, paying particular attention to the differences between retained and non-retained students. METHODOLOGY: A two-group quasi-experimental design incorporating pre-testing and post-testing was used...
May 2018: Psicothema
https://www.readbyqxmd.com/read/29693968/determinants-of-breast-cancer-screening-by-mammography-in-women-referred-to-health-centers-of-urmia-iran
#17
Fatemeh Moghaddam Tabrizi, Sakineh Vahdati, Shahriar Khanahmadi, Samira Barjasteh
Background: In women, breast cancer accounts for 30 percent of all cancers and it is the second leading cause of mortality. Mammography is considered an effective procedure to detect early breast cancer recommended by World Health Organization. This study was aimed to evaluate breast cancer screening determinants in women referred to health centers of Urmia for mammography in 2017. Materials and Methods: In this descriptive-analytic cross-sectional study, 348 women referred to health centers of Urmia were selected using multistage sampling...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29693750/protein-phosphatase-2a-mediates-js-k-induced-apoptosis-by-affecting-bcl-2-family-proteins-in-human-hepatocellular-carcinoma-hepg2-cells
#18
Ling Liu, Zile Huang, Jingjing Chen, Jiangang Wang, Shuying Wang
Protein phosphatase 2A (PP2A) is an important enzyme within various signal transduction pathways. The present study was investigated PP2A mediates JS-K-induced apoptosis by affecting Bcl-2 family protein. JS-K showed diverse inhibitory effects in five HCC cell lines, especially HepG2 cells. JS-K caused a dose- and time-dependent reduction in cell viability and increased in levels of LDH release. Meanwhile, JS-K- induced apoptosis was characterized by mitochondrial membrane potential reduction, Hoechst 33342+ /PI+ dual staining, release of cytochrome c (Cyt c), and activation of cleaved caspase-9/3...
April 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29693726/uterotonic-agents-for-preventing-postpartum-haemorrhage-a-network-meta-analysis
#19
REVIEW
Ioannis D Gallos, Helen M Williams, Malcolm J Price, Abi Merriel, Harold Gee, David Lissauer, Vidhya Moorthy, Aurelio Tobias, Jonathan J Deeks, Mariana Widmer, Özge Tunçalp, Ahmet Metin Gülmezoglu, G Justus Hofmeyr, Arri Coomarasamy
BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide. Prophylactic uterotonic drugs can prevent PPH, and are routinely recommended. There are several uterotonic drugs for preventing PPH but it is still debatable which drug is best. OBJECTIVES: To identify the most effective uterotonic drug(s) to prevent PPH, and generate a ranking according to their effectiveness and side-effect profile. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (1 June 2015), ClinicalTrials...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29693716/parental-divorce-and-family-history-of-alcohol-disorder-associations-with-young-adults-alcohol-problems-marijuana-use-and-interpersonal-relations
#20
Michael Windle, Rebecca C Windle
BACKGROUND: This study used prospective data from 706 young adults to evaluate the impact of parental divorce and family history of alcoholism (FH+) on the outcomes of offspring alcohol problems, marijuana use, and interpersonal relationships with parents. METHODS: Assessments of parental divorce were based on parent reports, and young adult outcomes were collected from an offspring cohort (n = 706; X age = 33.25 years; females = 53%) via computer-based individual interviews (CAPI and ACASI)...
April 25, 2018: Alcoholism, Clinical and Experimental Research
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