keyword
https://read.qxmd.com/read/38643704/milligram-scale-enantioresolution-of-promethazine-and-its-main-metabolites-determination-of-their-absolute-configuration-and-assessment-of-enantioselective-effects-on-human-sy-sy5y-cells
#1
JOURNAL ARTICLE
Maria Miguel Coelho, Inês Costa, Ana Carolina Ferreira de Albuquerque, Fernando Martins Dos Santos Junior, Bárbara Silva, Renata Silva, Carla Fernandes, Fernando Remião, Maria Elizabeth Tiritan
The misuse of pharmaceuticals has significantly increased in recent decades, becoming a major public health concern. The risks associated with medication misuse are particularly high in cases of overdose, especially when the active substances are chiral, as enantioselectivity plays an important role in toxicity. Promethazine (PMZ) is a chiral antihistamine marketed as a racemate and it is misused in "Purple Drank", a recreational drug beverage, that combines codeine and/or PMZ, with soda or alcohol leading to serious health consequences and fatalities in consumers around the world, particularly among teenagers...
April 15, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38642974/teenage-boy-with-a-painful-forearm
#2
JOURNAL ARTICLE
Chien-Yu Liao, Tou-Yuan Tsai, Yi-Kung Lee, Yu-Ting Chen
No abstract text is available yet for this article.
May 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38642024/dysmenorrhea-in-tunisian-high-school-adolescent-girls-frequency-effects-and-absence-from-school
#3
JOURNAL ARTICLE
Badra Bannour, Nour Rouis, Rania Bannour, Chourouk Alouane, Souhir Saadouli, Imen Bannour
OBJECTIVES: Dysmenorrhea is a known phenomenon and not just recently, and investigations conducted recently have shown that female adolescents are very susceptible to this condition. Our goal is to determine the prevalence of dysmenorrhea in Tunisia, its risk factors, its impact on truancy rates, and the therapeutic attitudes of girls attending high school about this illness using an epidemiological survey. METHODS: This eight-month study, which spans from October 2022 to May 2023, focuses on 160 high school girls between the ages of 13 and 21...
April 22, 2024: International Journal of Adolescent Medicine and Health
https://read.qxmd.com/read/38641857/express-pro-inflammatory-cytokine-alterations-in-recent-onset-anorexia-nervosa-adolescent-female-patients-before-and-after-6-months-of-integrated-therapy-a-case-control-study
#4
JOURNAL ARTICLE
Alice Di Paolo, Valentina Membrino, Sonila Alia, Laura Nanetti, Lucia Emanuela Svarca, Massimo Leone Perrone, Luca Aquilanti, Laura Mazzanti, Arianna Vignini, Eleonora Salvolini, Michele Severini
Anorexia nervosa (AN) is a complex disorder affecting mainly, but not only, teenagers. Researchers agree that AN is deeply associated with a pro-inflammatory state following an impaired immune system, resulting from altered levels of cytokines such as IL-1β and TNF-α, also impacted by the frequent depressive states. Thus, the aim of the present case-control study was to evaluate the relationship between patients suffering from AN undergoing specialized eating disorder (ED) treatment for AN and pro-inflammatory cytokines...
April 19, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/38639794/child-participation-during-outpatient-consultations-a-mixed-methods-study
#5
JOURNAL ARTICLE
Maud M Koenis, Heleen Vroman, Paul L P Brand, Christiaan S van Woerden
UNLABELLED: Although children wish to be included in their own healthcare, they recognize a gap between their right to be heard and their ability to become involved. Despite adaptation of medical consultation styles which suit a more patient-centered approach, data on the current state of child participation in clinical encounters are missing. We aimed to assess actual child participation in a Dutch pediatric clinic. Children aged 4-18 years visiting a pediatric outpatient clinic for consultation after general practitioner's referral were included...
April 19, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38639691/qualitative-exploration-of-health-professionals-perceptions-of-addressing-malnutrition-within-the-first-1-000-days
#6
JOURNAL ARTICLE
Marian Joyce Nyarko, Wilma Ten Ham-Baloyi, Dalena R M van Rooyen
OBJECTIVE: Explore health professionals' perceptions toward how to address malnutrition within the first 1,000 days of life in underresourced communities. DESIGN: A qualitative explorative-descriptive study using 8 face-to-face focus group discussions. SETTING: Health facilities serving underresourced communities within Nelson Mandela Bay, Eastern Cape Province, South Africa. PARTICIPANTS: Fifty-six health professionals (n = 13 doctors, n = 28 nurses, n = 6 dietitians, and n = 9 social workers) aged between 20 and 60 years, with 1-16 years (5 years average) of working experience...
April 19, 2024: Journal of Nutrition Education and Behavior
https://read.qxmd.com/read/38636834/halogenated-aromatic-pollutants-in-routine-animal-derived-food-of-south-china-occurrence-sources-and-dietary-intake-risks
#7
JOURNAL ARTICLE
Li-Na Zhang, Ping-An Peng, Hui-Ru Li, Ming-Yang Liu, Jian-Fang Hu
Halogenated aromatic pollutants (HAPs) including polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated dibenzo-p-dioxins/furans (PBDD/Fs), and polybrominated diphenyl ethers (PBDEs) exhibit diverse toxicities and bio-accumulation in animals, thereby imposing risks on human via animal-derived food (ADF) consumption. Here we examined these HAPs in routine ADFs from South China and observed that PBDEs and PCBs showed statistically higher concentrations than PCDD/Fs and PBDD/Fs...
April 16, 2024: Environmental Pollution
https://read.qxmd.com/read/38634489/access-to-adolescent-sexual-and-reproductive-health-services-in-accra-ghana-an-exploratory-qualitative-study
#8
JOURNAL ARTICLE
Divya Parmar, Semira Berhe, Susan Bradley, Ama Fenny, Lydia Aziato, Haddijatou Ceesay
Nearly 31% of the Ghanaian population are adolescents, and these populations persistently face high rates of teenage pregnancies and unsafe abortions. This is despite sexual and reproductive health (SRH) being taught in the school curriculum. In this qualitative study, we explore the factors affecting adolescents' access to, and experiences of, SRH services in Accra, Ghana. We conducted 12 focus group discussions (FGDs) with adolescents and 13 key informant interviews (KIs) in Ghana. The FGDs were conducted with school-going and out-of-school adolescents...
January 2024: Global Public Health
https://read.qxmd.com/read/38634103/the-impact-of-new-regulations-on-prevention-and-control-of-e-cigarettes-on-adolescents-in-middle-schools-a-city-in-china-2022-2023
#9
JOURNAL ARTICLE
Meng Lyu, Wenlong Lu, Lanhua Zou, Jingfan Xiong, Jie Yang
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: To protect the health of young people from the harmful impacts of electronic cigarettes (e-cigarettes), China has enacted various policies and regulations since 2018. As of October 1, 2022, the Electronic Cigarette Management Measures were put into action. They prohibited the sale of flavored e-cigarettes, permitting only those of plain tobacco flavor to be sold. WHAT IS ADDED BY THIS REPORT?: The illegal market for flavored e-cigarettes, often disguised as milk tea cups, cola cans, and violent bear images, continues to flourish...
April 5, 2024: China CDC weekly
https://read.qxmd.com/read/38634100/injury-mortality-of-children-and-adolescents-aged-0-19-years-china-2010-2021
#10
JOURNAL ARTICLE
Jingtao Zhou, Min Zhao, Hao Huang, David C Schwebel, Peishan Ning, Zhenzhen Rao, Peixia Cheng, Li Li, Guoqing Hu
INTRODUCTION: To examine the recent trends in child injury mortality in China. METHODS: Injury mortality data of 2010-2021 for children and adolescents aged 0-19 years were from the China Health Statistics Yearbook. Injury mortality disparities across urban vs. rural locations, gender, and age groups were scrutinized. Annual percent change (APC), average annual percent change (AAPC), and their 95% confidence intervals (95% CI ) were estiamted usimg Joinpoint regression models...
April 5, 2024: China CDC weekly
https://read.qxmd.com/read/38634095/acute-acalculous-cholecystitis-complicated-by-infectious-mononucleosis-caused-by-cytomegalovirus
#11
Noriko Ide, Risa Hirata, So Motomura, Masaki Tago
KEY CLINICAL MESSAGE: When seeing patients who present with atypical lymphocytes and abdominal pain without accompanying symptoms of pharyngitis or lymphadenopathy, acalculous cholecystitis caused by CMV infection should be considered as a differential diagnosis. ABSTRACT: A teenage man presented with a fever and epigastric pain. The patient tested positive for cytomegalovirus IgG and IgM. Abdominal ultrasonography and contrast-enhanced CT revealed hepatosplenomegaly and gallbladder wall thickening...
April 2024: Clinical Case Reports
https://read.qxmd.com/read/38633972/osteosarcoma-in-a-teenage-athlete-with-a-swollen-knee-joint
#12
Amresh Gul, Zahid Khan
Osteosarcoma is a malignant mesenchymal tumour. This primarily manifests in the formation of immature osteoid cells by tumour cells. Osteosarcoma is the most common primary bone tumour in children and adolescents. It tends to occur in the metaphysis of long shafts, shows osteoblastic differentiation, and produces malignant osteoid material. We present the case of a 17-year-old male who presented to our clinic who had left knee pain for a few days. An initial radiograph of the knee joint revealed a lytic lesion in the proximal tibia and further imaging was advised...
March 2024: Curēus
https://read.qxmd.com/read/38633379/bilateral-tapia-syndrome-in-teenager-with-post-traumatic-hangman-s-fracture-and-carotid-artery-dissection
#13
Francesco Perrotta, Donato Piscopiello, Gaetano Iosa, Daniele Gemma, Daniela Rizzo, Francesca De Salvo, Davide D'Antini, Emanuele Scarano, Fabio Colonna
BACKGROUND: Tapia syndrome (TS) is a rare condition characterized by unilateral hypoglossal and recurrent laryngeal nerve palsy, leading to tongue deviation, swallowing difficulty and dysphonia. CASE REPORT: We describe a case of a 17-year-old boy who reported a bilateral TS following head and neck trauma with Hangman's fracture and right common carotid artery dissection. The confirmation occurred only after complete cognitive and motor recovery, verifying the inability to protrude the tongue and swallow, associated with complete paralysis of the vocal cords, diagnosed with fiber optic laryngoscopy...
June 2024: Trauma Case Reports
https://read.qxmd.com/read/38633058/the-effect-of-whey-protein-supplements-on-acne-vulgaris-among-male-adolescents-and-young-adults-a-case-control-study-from-north-of-jordan
#14
JOURNAL ARTICLE
Jihan Muhaidat, Almutazballlah Qablan, Faris Gharaibeh, Ghaith H Albataineh, Nour Abdo, Diala Alshiyab, Firas Al-Qarqaz
BACKGROUND: Young people and athletes willing to gain muscle mass and strength are likely to consume whey protein supplements. The effect of milk as a dietary source of whey protein on acne is still controversial. At the same time, a few studies have suggested an acnegenic impact of whey protein supplements. OBJECTIVES: To examine the association of whey protein supplements on acne risk among male adolescents and young adults. MATERIALS AND METHODS: 201 male teenagers and young adults attending fitness centers in Irbid/Jordan were involved in an observational case-control research; those with acne were deemed cases, and those without acne were considered controls...
2024: Dermatology Research and Practice
https://read.qxmd.com/read/38632671/health-related-quality-of-life-in-paediatric-patients-on-peritoneal-dialysis-data-from-a-tertiary-centre
#15
JOURNAL ARTICLE
Elias Hajj, Marijke Awouters, Melodie Mosca, Sacha Flammier, Sarra Rachedi, Justine Bacchetta, Aurelie De Mul, Bruno Ranchin
Kidney failure has a negative impact on both children and families' quality of life (QOL). We evaluated the burden of home peritoneal dialysis (PD) using two local questionnaires and the French version of PedsQL3.0 end-stage kidney disease module and family impact module. Data are expressed as median (min-max). We reviewed the charts of 12 patients, at a median age of 8.8 (1.2-16.7) years, undergoing maintenance PD for 8 (1-42) months. Parathyroid hormone and haemoglobin levels were 215 (17-606) ng/L and 117 (104-141) g/L, respectively...
April 17, 2024: Peritoneal Dialysis International
https://read.qxmd.com/read/38631641/urinary-phthalate-dinch-metabolites-associations-with-kisspeptin-and-reproductive-hormones-in-teenagers-a-cross-sectional-study-from-the-hbm4eu-aligned-studies
#16
JOURNAL ARTICLE
Andrea Rodríguez-Carrillo, Sylvie Remy, Gudrun Koppen, Natasha Wauters, Vicente Mustieles, Anteneh Desalegn, Nina Iszatt, Elly den Hond, Veerle J Verheyen, Lucia Fábelová, Lubica Palkovicova Murinova, Susana Pedraza-Díaz, Marta Esteban, Rafael M Poyatos, Eva Govarts, Alexander L N van Nuijs, Adrian Covaci, Greet Schoeters, Nicolás Olea, Mariana F Fernández
BACKGROUND: Exposure to phthalate/DINCH metabolites can induce human reproductive toxicity, however, their endocrine-disrupting mechanisms are not fully elucidated. OBJECTIVE: To investigate the association between concentrations of phthalate/DINCH metabolites, serum kisspeptin, and reproductive hormones among European teenagers from three of the HBM4EU Aligned Studies. METHODS: In 733 Belgian (FLEHS IV study), Slovak (PCB cohort follow-up), and Spanish (BEA study) teenagers, ten phthalate and two DINCH metabolites were measured in urine by high-performance liquid chromatography-tandem mass spectrometry...
April 15, 2024: Science of the Total Environment
https://read.qxmd.com/read/38631089/phthalates-and-substitute-plasticizers-main-achievements-from-the-european-human-biomonitoring-initiative-hbm4eu
#17
REVIEW
Antje Gerofke, Rosa Lange, Nina Vogel, Phillipp Schmidt, Till Weber, Madlen David, Hanne Frederiksen, Kirsten Baken, Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Žanna Martinsone, Tiina Santonen, Greet Schoeters, Martin Scheringer, Elena Domínguez-Romero, Marta Esteban López, Argelia Castaño Calvo, Holger M Koch, Petra Apel, Marike Kolossa-Gehring
Phthalates and the substitute plasticizer DINCH belong to the first group of priority substances investigated by the European Human Biomonitoring Initiative (HBM4EU) to answer policy-relevant questions and safeguard an efficient science-to-policy transfer of results. Human internal exposure levels were assessed using two data sets from all European regions and Israel. The first collated existing human biomonitoring (HBM) data (2005-2019). The second consisted of new data generated in the harmonized "HBM4EU Aligned Studies" (2014-2021) on children and teenagers for the ten most relevant phthalates and DINCH, accompanied by a quality assurance/quality control (QA/QC) program for 17 urinary exposure biomarkers...
April 16, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38631035/fostering-digital-life-skills-through-social-media-with-adolescents-in-6-german-states-protocol-for-an-accessibility-study-according-to-the-re-aim-framework
#18
JOURNAL ARTICLE
Elizabeth Zimmermann, Samuel Tomczyk
BACKGROUND: Social media is essential in the lives of adolescents, with 97% of US teenagers engaging daily. While it facilitates communication, learning, and identity development, it also poses risks like harmful content exposure and psychological distress, particularly for adolescents in their critical developmental stage. Teaching digital life skills innovatively counters these risks, adapting traditional competencies such as decision-making, problem-solving, creative and critical thinking, communication, interpersonal skills, self-awareness, empathy, and emotional and stress management to digital challenges...
April 17, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38630744/teenage-blues-predictors-of-depression-among-adolescents-in-nigeria
#19
JOURNAL ARTICLE
Adefunke DadeMatthews, Chukwuemeka Nzeakah, Lucky Onofa, Oluwagbemiga DadeMatthews, Temitope Ogundare
BACKGROUND: Depressive disorders, with a prevalence of 15-21%, are among the most common disorders in children and adolescents, and increases the risk of suicide, the second leading cause of death in children aged 10 to 19. AIM: To determine the prevalence and correlates of depressive disorders among senior students attending secondary schools in Abeokuta. METHOD: The study was conducted in five schools randomly selected from a representative sample and was carried out in 2 phases...
2024: PloS One
https://read.qxmd.com/read/38629108/-it-made-me-feel-like-a-shit-parent-an-intersectional-analysis-of-pandemic-mothering
#20
JOURNAL ARTICLE
Holly Thorpe, Nikki Barrett, Mihi Joy Nemani, Grace O'Leary, Nida Ahmad
The COVID-19 pandemic brought to the fore the everyday and exceptional challenges for mothers. Rarely, however, did research or social commentary acknowledge the multiplicities of motherhood during this prolonged period of risk, disruption, and uncertainty. This paper draws upon interviews with 24 mothers living in Aotearoa New Zealand during the pandemic, including women who were pregnant and gave birth during lockdowns, teenage mothers, single and low-income mothers, and working mothers. The sample was intentionally diverse, including Māori, Pacific, Asian and migrant mothers...
2024: Frontiers in sociology
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