keyword
MENU ▼
Read by QxMD icon Read
search

Espirituality

keyword
https://www.readbyqxmd.com/read/28092244/-depression-and-burden-on-primary-caregivers-of-elderly-persons-with-physical-dependence-of-the-umf-171
#1
Cristina Navarro-Sandoval, Lizbeth Carlota Uriostegui-Espíritu, Edna Gabriela Delgado-Quiñones, Minerva Natalia Sahagún-Cuevas
BACKGROUND: According to the National Health and Nutrition Survey of 2012, more than a quarter of older adults (26.9%) have some degree of disability, requiring a primary caregiver to perform basic activities of daily living. The aim is to determine the prevalence of depression and burden on primary caregivers of elderly persons with physical dependence. METHODS: A descriptive cross-sectional study with non-probability sampling that included the primary caregivers of elderly patients with physical dependence...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28068672/genomic-hallmarks-of-localized-non-indolent-prostate-cancer
#2
Michael Fraser, Veronica Y Sabelnykova, Takafumi N Yamaguchi, Lawrence E Heisler, Julie Livingstone, Vincent Huang, Yu-Jia Shiah, Fouad Yousif, Xihui Lin, Andre P Masella, Natalie S Fox, Michael Xie, Stephenie D Prokopec, Alejandro Berlin, Emilie Lalonde, Musaddeque Ahmed, Dominique Trudel, Xuemei Luo, Timothy A Beck, Alice Meng, Junyan Zhang, Alister D'Costa, Robert E Denroche, Haiying Kong, Shadrielle Melijah G Espiritu, Melvin L K Chua, Ada Wong, Taryne Chong, Michelle Sam, Jeremy Johns, Lee Timms, Nicholas B Buchner, Michèle Orain, Valérie Picard, Helène Hovington, Alexander Murison, Ken Kron, Nicholas J Harding, Christine P'ng, Kathleen E Houlahan, Kenneth C Chu, Bryan Lo, Francis Nguyen, Constance H Li, Ren X Sun, Richard de Borja, Christopher I Cooper, Julia F Hopkins, Shaylan K Govind, Clement Fung, Daryl Waggott, Jeffrey Green, Syed Haider, Michelle A Chan-Seng-Yue, Esther Jung, Zhiyuan Wang, Alain Bergeron, Alan Dal Pra, Louis Lacombe, Colin C Collins, Cenk Sahinalp, Mathieu Lupien, Neil E Fleshner, Housheng H He, Yves Fradet, Bernard Tetu, Theodorus van der Kwast, John D McPherson, Robert G Bristow, Paul C Boutros
Prostate tumours are highly variable in their response to therapies, but clinically available prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 whole-genome sequences and 277 additional whole-exome sequences from localized, non-indolent prostate tumours with similar clinical risk profiles, and carried out RNA and methylation analyses in a subset. These tumours had a paucity of clinically actionable single nucleotide variants, unlike those seen in metastatic disease. Rather, a significant proportion of tumours harboured recurrent non-coding aberrations, large-scale genomic rearrangements, and alterations in which an inversion repressed transcription within its boundaries...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/28067867/germline-brca2-mutations-drive-prostate-cancers-with-distinct-evolutionary-trajectories
#3
Renea A Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G Lawrence, Lee Timms, Declan G Murphy, Mark Frydenberg, Julia F Hopkins, Damien Bolton, David Clouston, John D McPherson, Theodorus van der Kwast, Paul C Boutros, Gail P Risbridger, Robert G Bristow
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, here we profile the genomes and methylomes of localized PCa from 14 carriers of deleterious germline BRCA2 mutations (BRCA2-mutant PCa). We show that BRCA2-mutant PCa harbour increased genomic instability and a mutational profile that more closely resembles metastastic than localized disease. BRCA2-mutant PCa shows genomic and epigenomic dysregulation of the MED12L/MED12 axis, which is frequently dysregulated in metastatic castration-resistant prostate cancer (mCRPC)...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/27970006/tct-631-a-robust-ex-vivo-functional-mitral-valve-model-to-test-novel-transcatheter-mitral-valve-devices
#4
Daniella Espiritu, Kirthana Suresh, Qi He, Daisuke Onohara, Muralidhar Padala
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27922225/study-of-the-chemical-space-of-selected-bacteriostatic-sulfonamides-from-an-information-theory-point-of-view
#5
Sheila López-Rosa, Moyocoyani Molina-Espíritu, Rodolfo O Esquivel, Catalina Soriano-Correa, Jésus S Dehesa
The relative structural location of a selected group of 27 sulfonamide-like molecules in a chemical space defined by three information theory quantities (Shannon entropy, Fisher information, and disequilibrium) is discussed. This group is composed of 15 active bacteriostatic molecules, 11 theoretically designed ones, and para-aminobenzoic acid. This endeavor allows molecules that share common chemical properties through the molecular backbone, but with significant differences in the identity of the chemical substituents, which might result in bacteriostatic activity, to be structurally classified and characterized...
December 5, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27900107/preclinical-trial-on-the-use-of-doxycycline-for-the-treatment-of-adenocarcinoma-of-the-duodenum
#6
Hector R Galván-Salazar, Alejandro D Soriano-Hernández, Daniel A Montes-Galindo, Gabriel Ceja Espíritu, José Guzman-Esquivel, Iram P Rodríguez-Sánchez, Oscar A Newton-Sánchez, Margarita L Martinez-Fierro, Xóchitl G Briseño Gómez, Augusto Rojas-Martínez, Iván Delgado-Enciso
Adenocarcinoma of the duodenum comprises 50-70% of duodenal tumors. There is an increase in extracellular matrix metalloproteinases in this disease and it has been suggested that they play an important role in the development and pathology. Therefore, new therapeutic recommendations based on inhibitors of these enzymes, such as doxycycline, are under investigation. The cytotoxic effect of doxycycline was evaluated in the HuTu-80 duodenal adenocarcinoma cell line and its antitumor effect was determined in an immunodeficient murine model...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27673252/poster-511-evaluating-burnout-in-physical-medicine-and-rehabilitation-residents
#7
Daniel J Kao, Kevin Franzese, Young Il Seo, Neil V Mandalaywala, Kunal Oak, Alex Moroz, Tracy Espiritu, Derek J Ho
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27672840/poster-72-teetering-on-the-edge-rehabilitation-in-a-medically-complex-patient-with-familial-dysautonomia-hereditary-sensory-autonomic-neuropathy-type-iii-a-case-report
#8
Derek J Ho, Daniel J Kao, Tracy Espiritu
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27672839/poster-71-new-frontiers-inpatient-comprehensive-rehabilitation-after-full-face-transplantation-a%C3%A2-case-report
#9
Tracy Espiritu McKay, Matina Balou, Daniel J Kao, Derek J Ho, Jeffrey Cohen, Eduardo D Rodriguez
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27670898/soluble-adenylyl-cyclase-is-essential-for-proper-lysosomal-acidification
#10
Nawreen Rahman, Lavoisier Ramos-Espiritu, Teresa A Milner, Jochen Buck, Lonny R Levin
Lysosomes, the degradative organelles of the endocytic and autophagic pathways, function at an acidic pH. Lysosomes are acidified by the proton-pumping vacuolar ATPase (V-ATPase), but the molecular processes that set the organelle's pH are not completely understood. In particular, pH-sensitive signaling enzymes that can regulate lysosomal acidification in steady-state physiological conditions have yet to be identified. Soluble adenylyl cyclase (sAC) is a widely expressed source of cAMP that serves as a physiological pH sensor in cells...
October 2016: Journal of General Physiology
https://www.readbyqxmd.com/read/27651985/seasonal-changes-in-fish-assemblage-structure-at-a-shallow-seamount-in-the-gulf-of-california
#11
Salvador J Jorgensen, A Peter Klimley, Arturo Muhlia-Melo, Steven G Morgan
Seamounts have generally been identified as locations that can promote elevated productivity, biomass and predator biodiversity. These properties attract seamount-associated fisheries where elevated harvests can be obtained relative to surrounding areas. There exists large variation in the geological and oceanographic environment among the thousands of locations that fall within the broad definition of seamount. Global seamount surveys have revealed that not all seamounts are hotspots of biodiversity, and there remains a strong need to understand the mechanisms that underlie variation in species richness observed...
2016: PeerJ
https://www.readbyqxmd.com/read/27601372/sterol-dependent-membrane-association-of-the-marine-sponge-derived-bicyclic-peptide-theonellamide-a-as-examined-by-1-h-nmr
#12
Kimberly Cornelio, Rafael Atillo Espiritu, Yasuto Todokoro, Shinya Hanashima, Masanao Kinoshita, Nobuaki Matsumori, Michio Murata, Shinichi Nishimura, Hideaki Kakeya, Minoru Yoshida, Shigeki Matsunaga
Theonellamide A (TNM-A) is an antifungal bicyclic dodecapeptide isolated from a marine sponge Theonella sp. Previous studies have shown that TNM-A preferentially binds to 3β-hydroxysterol-containing membranes and disrupts membrane integrity. In this study, several (1)H NMR-based experiments were performed to investigate the interaction mode of TNM-A with model membranes. First, the aggregation propensities of TNM-A were examined using diffusion ordered spectroscopy; the results indicate that TNM-A tends to form oligomeric aggregates of 2-9 molecules (depending on peptide concentration) in an aqueous environment, and this aggregation potentially influences the membrane-disrupting activity of the peptide...
November 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27563989/tunable-symmetries-of-integer-and-fractional-quantum-hall-phases-in-heterostructures-with-multiple-dirac-bands
#13
Petr Stepanov, Yafis Barlas, Tim Espiritu, Shi Che, Kenji Watanabe, Takashi Taniguchi, Dmitry Smirnov, Chun Ning Lau
The copresence of multiple Dirac bands in few-layer graphene leads to a rich phase diagram in the quantum Hall regime. Using transport measurements, we map the phase diagram of BN-encapsulated ABA-stacked trilayer graphene as a function charge density n, magnetic field B, and interlayer displacement field D, and observe transitions among states with different spin, valley, orbital, and parity polarizations. Such a rich pattern arises from crossings between Landau levels from different subbands, which reflect the evolving symmetries that are tunable in situ...
August 12, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27547922/discovery-of-lre1-as-a-specific-and-allosteric-inhibitor-of-soluble-adenylyl-cyclase
#14
Lavoisier Ramos-Espiritu, Silke Kleinboelting, Felipe A Navarrete, Antonio Alvau, Pablo E Visconti, Federica Valsecchi, Anatoly Starkov, Giovanni Manfredi, Hannes Buck, Carolina Adura, Jonathan H Zippin, Joop van den Heuvel, J Fraser Glickman, Clemens Steegborn, Lonny R Levin, Jochen Buck
The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally in independently regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP: G-protein-regulated transmembrane adenylyl cyclases and bicarbonate-, calcium- and ATP-regulated soluble adenylyl cyclase (sAC). Because each type of cyclase regulates distinct microdomains, methods to distinguish between them are needed to understand cAMP signaling...
October 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27323809/the-metabolic-ph-sensor-soluble-adenylyl-cyclase-is-a-tumor-suppressor-protein
#15
Lavoisier Ramos-Espiritu, Ana Diaz, Charlee Nardin, Anthony J Saviola, Fiona Shaw, Tamar Plitt, Xia Yang, Jedd Wolchok, Edyta C Pirog, Garrett Desman, Andrea Sboner, Tuo Zhang, Jenny Xiang, Taha Merghoub, Lonny R Levin, Jochen Buck, Jonathan H Zippin
cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27276017/vulnerability-to-alcohol-consumption-spiritual-transcendence-and-psychosocial-well-being-test-of-a-theory
#16
Luz Patricia Díaz Heredia, Alba Idaly Muñoz Sanchez
OBJECTIVE: to demonstrate the relations among vulnerability, self-transcendence and well-being in the young adult population and the effect of each of these variables on the adoption of low-risk consumption conducts. METHOD: quantitative and cross-sectional correlation study using structural equations analysis to test the relation among the variables. RESULTS: an inverse relation was evidenced between vulnerability to alcohol consumption and spiritual transcendence (β-0...
June 7, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27271997/t-boc-synthesis-of-huwentoxin-i-through-native-chemical-ligation-incorporating-a-trifluoromethanesulfonic-acid-cleavage-strategy
#17
Parashar Thapa, Chino C Cabalteja, Edwin E Philips, Michael J Espiritu, Steve Peigneur, Bea G Mille, Jan Tytgat, Theodore R Cummins, Jon-Paul Bingham
Tert-butyloxycarbonyl (t-Boc)-based native chemical ligation (NCL) techniques commonly employ hydrogen fluoride (HF) to create the thioester fragment required for the ligation process. Our research aimed to assess the replacement of HF with Trifluoromethanesulfonic acid (TFMSA). Here we examined a 33 amino acid test peptide, Huwentoxin-I (HwTx-I) as a novel candidate for our TFMSA cleavage protocol. Structurally HwTx-I has an X-Cys(16) -Cys(17) -X sequence mid-region, which makes it an ideal candidate for NCL...
September 2016: Biopolymers
https://www.readbyqxmd.com/read/27262620/computational-predictions-suggest-that-structural-similarity-in-viral-polymerases-may-lead-to-comparable-allosteric-binding-sites
#18
Jodian A Brown, Marie V Espiritu, Joel Abraham, Ian F Thorpe
The identification of ligand-binding sites is often the first step in drug targeting and design. To date there are numerous computational tools available to predict ligand binding sites. These tools can guide or mitigate the need for experimental methods to identify binding sites, which often require significant resources and time. Here, we evaluate four ligand-binding site predictor (LBSP) tools for their ability to predict allosteric sites within the Hepatitis C Virus (HCV) polymerase. Our results show that the LISE LBSP is able to identify all three target allosteric sites within the HCV polymerase as well as a known allosteric site in the Coxsackievirus polymerase...
August 15, 2016: Virus Research
https://www.readbyqxmd.com/read/27234818/transcatheter-mitral-valve-repair-therapies-evolution-status-and-challenges
#19
Daniella Espiritu, Daisuke Onohara, Kanika Kalra, Eric L Sarin, Muralidhar Padala
Mitral regurgitation is a common cardiac valve lesion, developing from primary lesions of the mitral valve or secondary to cardiomyopathies. Moderate or higher severity of mitral regurgitation imposes significant volume overload on the left ventricle, causing permanent structural and functional deterioration of the myocardium and heart failure. Timely correction of regurgitation is essential to preserve cardiac function, but surgical mitral valve repair is often delayed due to the risks of open heart surgery...
May 27, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27159918/membrane-permeabilizing-action-of-amphidinol-3-and-theonellamide-a-in-raft-forming-lipid-mixtures
#20
Rafael A Espiritu
Amphidinol 3 (AM3) and theonellamide A (TNM-A) are potent antifungal compounds produced by the dinoflagellate Amphidinium klebsii and the sponge Theonella spp., respectively. Both of these metabolites have been demonstrated to interact with membrane lipids ultimately resulting in a compromised bilayer integrity. In this report, the activity of AM3 and TNM-A in ternary lipid mixtures composed of 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (POPC):brain sphingomyelin:cholesterol at a mole ratio of 1:1:1 or 3:1:1 exhibiting lipid rafts coexistence is presented...
May 9, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
keyword
keyword
35481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"