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Iván A Valdespino, Christian A López, Adriel M Sierra, Jorge Ceballos
We describe four new species in the genus Selaginella (i.e., S . agioneuma, S. magnafornensis , S . ventricosa , and S . zartmanii ) from Brazil, all presently classified in subg. Stachygynandrum . For each of the new taxa we discuss taxonomic affinities and provide information on habitat, distribution, and conservation status. In addition, line drawings and scanning electron microscope (SEM) images of stems sections, leaves, and spores (when present) are included. Selaginella agioneuma and S. magnafornensis are from the State of Espíritu Santo where they inhabit premontane to montane Atlantic rain forests in the Reserva Biológica Augusto Ruschi and Parque Estadual Forno Grande, respectively...
2018: PeerJ
Shadrielle Melijah G Espiritu, Lydia Y Liu, Yulia Rubanova, Vinayak Bhandari, Erle M Holgersen, Lesia M Szyca, Natalie S Fox, Melvin L K Chua, Takafumi N Yamaguchi, Lawrence E Heisler, Julie Livingstone, Jeff Wintersinger, Fouad Yousif, Emilie Lalonde, Alexandre Rouette, Adriana Salcedo, Kathleen E Houlahan, Constance H Li, Vincent Huang, Michael Fraser, Theodorus van der Kwast, Quaid D Morris, Robert G Bristow, Paul C Boutros
The majority of newly diagnosed prostate cancers are slow growing, with a long natural life history. Yet a subset can metastasize with lethal consequences. We reconstructed the phylogenies of 293 localized prostate tumors linked to clinical outcome data. Multiple subclones were detected in 59% of patients, and specific subclonal architectures associate with adverse clinicopathological features. Early tumor development is characterized by point mutations and deletions followed by later subclonal amplifications and changes in trinucleotide mutational signatures...
May 3, 2018: Cell
Uriel A López-Lemus, Raquel Garza-Guajardo, Oralia Barboza-Quintana, Alejandrina Rodríguez-Hernandez, Alejandro García-Rivera, Violeta M Madrigal-Pérez, José Guzmán-Esquivel, Laura E García-Labastida, Alejandro D Soriano-Hernández, Margarita L Martínez-Fierro, Iram P Rodríguez-Sánchez, Elizabeth Sánchez-Duarte, Ariana Cabrera-Licona, Gabriel Ceja-Espiritu, Iván Delgado-Enciso
Metabolic syndrome (MS) has been associated with testicular damage. Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease that affects different organs, but its effect on the testes is unknown. A study analyzing germ cell involvement on BALB/c mice was carried out. A parallel comparative study was conducted that investigated alterations in the germinal epithelium of male humans that died from an unrelated acute event. The complete medical histories and histologic samples of the thoracic aorta, liver tissue, and testicular tissue from the deceased subjects were collected...
March 1, 2018: American Journal of Men's Health
Natasha Shapiro, Elena V Wachtel, Sean M Bailey, Michael M Espiritu
OBJECTIVE: To assess whether neonatologists show implicit racial and/or socioeconomic biases and whether these are predictive of recommendations at extreme periviability. STUDY DESIGN: A nationwide survey using a clinical vignette of a woman in labor at 232/7 weeks of gestation asked physicians how likely they were to recommend intensive vs comfort care. Participants were randomized to 1 of 4 versions of the vignette in which racial and socioeconomic stimuli were varied, followed by 2 implicit association tests (IATs)...
March 20, 2018: Journal of Pediatrics
Yanmeng Shi, Shi Che, Kuan Zhou, Supeng Ge, Ziqi Pi, Timothy Espiritu, Takashi Taniguchi, Kenji Watanabe, Yafis Barlas, Roger Lake, Chun Ning Lau
As the Fermi level and band structure of two-dimensional materials are readily tunable, they constitute an ideal platform for exploring the Lifshitz transition, a change in the topology of a material's Fermi surface. Using tetralayer graphene that host two intersecting massive Dirac bands, we demonstrate multiple Lifshitz transitions and multiband transport, which manifest as a nonmonotonic dependence of conductivity on the charge density n and out-of-plane electric field D, anomalous quantum Hall sequences and Landau level crossings that evolve with n, D, and B...
March 2, 2018: Physical Review Letters
Ivan Delgado-Enciso, Brenda Paz-Michel, Valery Melnikov, Jose Guzman-Esquivel, Francisco Espinoza-Gomez, Alejandro D Soriano-Hernandez, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Gabriel Ceja-Espiritu, Bertha A Olmedo-Buenrostro, Hector R Galvan-Salazar, Osiris G Delgado-Enciso, Josuel Delgado-Enciso, Uriel A Lopez-Lemus, Daniel A Montes-Galindo
Arthralgia is a potentially incapacitating condition and a persistent symptom in chronic or acute episodes of Chikungunya fever caused by infection with the Chikungunya virus (CHIKV). To the best of our knowledge, there are no reports on risk factors associated with the intensity of arthralgias in typical acute episodes of the disease. Although a number of studies have reported on risk factors associated with the development of the chronic stage of the disease, smoking habits have not been analyzed. Smoking is an interesting factor to consider since it is the main environmental risk factor for the development of rheumatoid arthritis (RA), a similar disease to CHIKV in many aspects...
March 2018: Experimental and Therapeutic Medicine
Iván Delgado-Enciso, Violeta M Madrigal-Perez, Agustin Lara-Esqueda, Martha G Diaz-Sanchez, Jose Guzman-Esquivel, Luis E Rosas-Vizcaino, Oscar O Virgen-Jimenez, Juleny Kleiman-Trujillo, Maria R Lagarda-Canales, Gabriel Ceja-Espiritu, Viridiana Rangel-Salgado, Uriel A Lopez-Lemus, Josuel Delgado-Enciso, Agustin D Lara-Basulto, Alejandro D Soriano Hernández
Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. The control group (n=10) was treated with the current standard treatment, which comprises of measures for reducing pressure in the ulcerated area, daily cleansing of the ulcer with potable water and antiseptic wash solution, and the application of a disinfectant solution on the entire surface area of the ulcer; while the intervention group (n=15) received the standard treatment plus 5% topical potassium permanganate solution applied once a day for 21 days...
February 2018: Biomedical Reports
Hwa I Han, Lauren B Skvarca, Eugenel B Espiritu, Alan J Davidson, Neil A Hukriede
Acute kidney injury (AKI) is defined by a rapid decline in renal function. Regardless of the initial cause of injury, the influx of immune cells is a common theme during AKI. While an inflammatory response is critical for the initial control of injury, a prolonged response can negatively affect tissue repair. In this review, we focus on the role of macrophages, from early inflammation to resolution, during AKI. These cells serve as the innate defense system by phagocytosing cellular debris and pathogenic molecules and bridge communication with the adaptive immune system by acting as antigen-presenting cells and secreting cytokines...
January 30, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Rui-Yang Zhang, Parashar Thapa, Michael J Espiritu, Vinay Menon, Jon-Paul Bingham
Cyclic peptides and cyclotides are becoming common identities within the present efforts seen in peptide engineering - as we seek approaches to achieve potent biological activity, pharmacological selectivity, structurally stability and oral bioavailability. Yet this unique family of peptides has faced uncommon hurdles in their discovery, synthesis and bioengineering, retaining to characteristics that truly deviate these from their linear counterparts. In this mini-review we take a board spectrum approach to introduce this novel family of biomolecules and the troubles that they face in their sequence and disulfide connectivity assignment, together highlighting the present combined strategies involved in cyclic peptide/cyclotide synthesis and modification...
March 15, 2018: Bioorganic & Medicinal Chemistry
Cesar Ramon G Espiritu, Joanne G Bolinao
Purpose: To evaluate posterior and anterior segment safety of an intracameral injection of levofloxacin 0.5% ophthalmic solution as prophylaxis for patients undergoing cataract extraction and intraocular lens implantation. Setting: This study was conducted at Manila Doctors Hospital, Ermita, Manila, Philippines. Design: This was a prospective interventional study. Methods: Eyes undergoing standard phacoemulsification cataract surgery with intraocular lens implantation were treated with intracameral levofloxacin 0...
2017: Clinical Ophthalmology
Eduardo Espiritu, Tien L Olson, JoAnn C Williams, James P Allen
The ability of an artificial four-helix bundle Mn-protein, P1, to bind and transfer an electron to photosynthetic reaction centers from the purple bacterium Rhodobacter sphaeroides was characterized using optical spectroscopy. Upon illumination of reaction centers, an electron is transferred from P, the bacteriochlorophyll dimer, to QA , the primary electron acceptor. The P1 Mn-protein can bind to the reaction center and reduce the oxidized bacteriochlorophyll dimer, P+ , with a dissociation constant of 1.2 μM at pH 9...
December 12, 2017: Biochemistry
Amanda L Woerman, Smita Patel, Sabeen A Kazmi, Abby Oehler, Yevgeniy Freyman, Lloyd Espiritu, Robert Cotter, Julian A Castaneda, Steven H Olson, Stanley B Prusiner
Importance: Accumulation of the protein tau is a defining characteristic of several neurodegenerative diseases. Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical for establishing the models used for testing anti-tau therapeutics in vivo. Objective: To define a consistent mouse model of disease for use in future compound efficacy studies. Design, Setting, and Participants: In this time course study, cohorts of Tg and control mice were euthanized at defined intervals...
December 1, 2017: JAMA Neurology
Jeff DeFalco, Michael Harbell, Amy Manning-Bog, Gilson Baia, Alexander Scholz, Beatriz Millare, May Sumi, Danhui Zhang, Felix Chu, Christine Dowd, Patricia Zuno-Mitchell, Dongkyoon Kim, Yvonne Leung, Shuwei Jiang, Xiaobin Tang, Kevin S Williamson, Xiaomu Chen, Sean M Carroll, Gregg Espiritu Santo, Nicole Haaser, Ngan Nguyen, Eldar Giladi, David Minor, Yann Chong Tan, Jeremy B Sokolove, Lawrence Steinman, Tito A Serafini, Guy Cavet, Norman M Greenberg, Jacob Glanville, Wayne Volkmuth, Daniel E Emerling, William H Robinson
There is significant debate regarding whether B cells and their antibodies contribute to effective anti-cancer immune responses. Here we show that patients with metastatic but non-progressing melanoma, lung adenocarcinoma, or renal cell carcinoma exhibited increased levels of blood plasmablasts. We used a cell-barcoding technology to sequence their plasmablast antibody repertoires, revealing clonal families of affinity matured B cells that exhibit progressive class switching and persistence over time. Anti-CTLA4 and other treatments were associated with further increases in somatic hypermutation and clonal family size...
February 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Tien L Olson, Eduardo Espiritu, Selvakumar Edwardraja, Elizabeth Canarie, Marco Flores, JoAnn C Williams, Giovanna Ghirlanda, James P Allen
To better understand metalloproteins with Mn-clusters, we have designed artificial four-helix bundles to have one, two, or three dinuclear metal centers able to bind Mn(II). Circular dichroism measurements showed that the Mn-proteins have substantial α-helix content, and analysis of electron paramagnetic resonance spectra is consistent with the designed number of bound Mn-clusters. The Mn-proteins were shown to catalyze the conversion of hydrogen peroxide into molecular oxygen. The loss of hydrogen peroxide was dependent upon the concentration of protein with bound Mn, with the proteins containing multiple Mn-clusters showing greater activity...
December 2017: Biochimica et Biophysica Acta
Federica Valsecchi, Csaba Konrad, Marilena D'Aurelio, Lavoisier S Ramos-Espiritu, Anna Stepanova, Suzanne R Burstein, Alexander Galkin, Jordi Magranè, Anatoly Starkov, Jochen Buck, Lonny R Levin, Giovanni Manfredi
cAMP regulates a wide variety of physiological functions in mammals. This single second messenger can regulate multiple, seemingly disparate functions within independently regulated cell compartments. We have previously identified one such compartment inside the matrix of the mitochondria, where soluble adenylyl cyclase (sAC) regulates oxidative phosphorylation (OXPHOS). We now show that sAC knockout fibroblasts have a defect in OXPHOS activity and attempt to compensate for this defect by increasing OXPHOS proteins...
November 1, 2017: Journal of Cell Science
Sarah-Grace Rota, Alessia Roma, Iulia Dude, Christina Ma, Robert Stevens, Janet MacEachern, Joanna Graczyk, Shaundrei Mabriel G Espiritu, Praveen N Rao, Mark D Minden, Elena Kreinin, David A Hess, Andrew C Doxey, Paul A Spagnuolo
Acute myeloid leukemia (AML) is a devastating disease characterized by poor patient outcome and suboptimal chemotherapeutics. Here, a high-throughput screen identified diosmetin, a citrus flavonoid, with anti-AML activity. Diosmetin imparted selective toxicity against leukemia and leukemia stem cells in vitro and in vivo with no effect on normal hematopoietic stem cells. Mechanistically, we demonstrated that diosmetin targets estrogen receptor (ER) β. ERβ expression conferred cell sensitivity, as patient-derived AML cells with high levels of ERβ were sensitive, whereas cells with low ERβ were insensitive to diosmetin...
November 2017: Molecular Cancer Therapeutics
Katarzyna Ibanez, Noel Espiritu, Regine L Souverain, Laura Stimler, Lauren Ward, Elyn R Riedel, Rachel Lehrman, Farid Boulad, Michael Dean Stubblefield
OBJECTIVE: To analyze the relation between platelet counts, intensities of physical therapy (PT) and occupational therapy (OT) services received, and frequencies of bleeding complications in children undergoing hematopoietic stem cell transplant (HSCT) during a period of severe thrombocytopenia. DESIGN: Retrospective review study. SETTING: Tertiary care hospital. PARTICIPANTS: Children (N=63; age, <18y) hospitalized for HSCT in 2010 and 2011 who received PT and OT services while markedly thrombocytopenic (platelet count, ≤50K/mcL)...
February 2018: Archives of Physical Medicine and Rehabilitation
Michael M Espiritu, Sean Bailey, Elena V Wachtel, Pradeep V Mally
BACKGROUND: Due to the extremely low incidence of TORCH (toxoplasmosis, rubella, CMV, herpes simplex virus) infections, diagnostic testing of all small for gestational age (SGA) infants aimed at TORCH etiologies may incur unnecessary tests and cost. OBJECTIVE: To determine the frequency of urine CMV PCR and total IgM testing among infants with birth weight <10% and the rate of test positivity. To evaluate the frequency of alternative etiologies of SGA in tested infants...
January 26, 2018: Journal of Perinatal Medicine
Calíope Pilger, Renata Ohana Pereira Dos Santos, Maicon Henrique Lentsck, Sueli Marques, Luciana Kusumota
Objective: To analyze the relationship between spiritual well-being, sociodemographic, economic, religious, and health variables and the quality of life of older adults undergoing hemodialysis. Method: This was a cross-sectional and correlational study conducted with 169 older adults undergoing hemodialysis. The researchers conducted interviews to collect sociodemographic, economic, religious, and health data and applied the Spiritual Well-Being Scale (SWBS) and the WHO quality of life assessment (WHOQOL-BREF and WHOQOL-OLD)...
July 2017: Revista Brasileira de Enfermagem
Chante Stubbs, Mavis N Schorn, Jacinta P Leavell, Elena Wong Espiritu, Gerald Davis, Chad K Gentry, Elisa Friedman, Traci Patton, Ali Graham, Ron Crowder, Consuelo H Wilkins
Many health professions programmes have begun integrating interprofessional learning into their curricula; however, community-based interprofessional education (IPE) initiatives are relatively scarce. The Meharry-Vanderbilt Alliance IPE Faculty Collaborative, comprised of faculty from five institutions, developed a community-based IPE programme that allowed students to engage in meaningful interprofessional activities while exposing them to social determinants of health. Thirty students from ten professions were divided into six teams and paired with three community organisations...
August 9, 2017: Journal of Interprofessional Care
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