keyword
https://read.qxmd.com/read/38508490/evaluation-of-the-analgesic-effects-of-diclofenac-as-a-premedication-drug-in-dogs-undergoing-ovariohysterectomy
#1
JOURNAL ARTICLE
C Mansour, R Najjar, R Chaaya
Pre-emptive analgesia consists of administering drugs such as opioids and nonsteroid anti-inflammatory drugs. This study aims to evaluate the intraoperative antinociceptive effects of diclofenac administered alone in premedication or combined with morphine along with its potential influence on recovery of dogs undergoing ovariohysterectomy. A total of 34 dogs (ASA I or II) admitted for ovariohysterectomy were randomly allocated into three groups according to the drugs given in premedication: Diclofenac (D) (n=11), Morphine (M) (n=13) and Diclofenac-Morphine (DM) (n=10) groups...
March 18, 2024: Topics in Companion Animal Medicine
https://read.qxmd.com/read/37480390/morphological-phytochemical-and-transcriptome-analyses-provide-insights-into-the-biosynthesis-of-monoterpenes-in-monarda-citriodora
#2
JOURNAL ARTICLE
Priyanka Sharma, Mir Abdul Wajid, Mohd Fayaz, Sheetal Bhat, Abhishek Kumar Nautiyal, Sabha Jeet, Arvind Kumar Yadav, Deepika Singh, Ravi Shankar, Sumeet Gairola, Prashant Misra
Morphological, phytochemical, and transcriptome analyses revealed candidate genes involved in the biosynthesis of volatile monoterpenes and development of glandular trichomes in Monarda citriodora. Monarda citriodora Cerv. ex Lag. is a valuable aromatic plant due to the presence of monoterpenes as major constituents in its essential oil (EO). Thus, it is of sheer importance to gain knowledge about the site of the biosynthesis of these terpenoid compounds in M. citriodora, as well as the genes involved in their biosynthesis...
July 22, 2023: Planta
https://read.qxmd.com/read/37464581/feasibility-evaluation-of-novel-ai-based-deep-learning-contouring-algorithm-for-radiotherapy
#3
JOURNAL ARTICLE
Luis A Maduro Bustos, Abhirup Sarkar, Laura A Doyle, Kelly Andreou, Jodie Noonan, Diana Nurbagandova, SunJay A Shah, Omoruyi Credit Irabor, Firas Mourtada
PURPOSE: To evaluate the clinical feasibility of the Siemens Healthineers AI-Rad Companion Organs RT VA30A (Organs-RT) auto-contouring algorithm for organs at risk (OARs) of the pelvis, thorax, and head and neck (H&N). METHODS: Computed tomography (CT) datasets from 30 patients (10 pelvis, 10 thorax, and 10 H&N) were collected. Four sets of OARs were generated on each scan, one set by Organs-RT and the others by three experienced users independently. A physician (expert) then evaluated each contour by assigning a score from the following scale: 1-Must Redo, 2-Major Edits, 3-Minor Edits, 4-Clinically usable...
July 18, 2023: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/37384599/the-cerv-protein-of-cer1-a-c-elegans-ltr-retrotransposon-is-required-for-nuclear-export-of-viral-genomic-rna-and-can-form-giant-nuclear-rods
#4
JOURNAL ARTICLE
Bing Sun, Haram Kim, Craig C Mello, James R Priess
Retroviruses and closely related LTR retrotransposons export full-length, unspliced genomic RNA (gRNA) for packaging into virions and to serve as the mRNA encoding GAG and POL polyproteins. Because gRNA often includes splice acceptor and donor sequences used to splice viral mRNAs, retroelements must overcome host mechanisms that retain intron-containing RNAs in the nucleus. Here we examine gRNA expression in Cer1, an LTR retrotransposon in C. elegans which somehow avoids silencing and is highly expressed in germ cells...
June 2023: PLoS Genetics
https://read.qxmd.com/read/36986824/comparative-hplc-dad-esi-qtof-ms-ms-analysis-of-bioactive-phenolic-compounds-content-in-the-methanolic-extracts-from-flowering-herbs-of-monarda-species-and-their-free-radical-scavenging-and-antimicrobial-activities
#5
JOURNAL ARTICLE
Małgorzata Kozyra, Anna Biernasiuk, Magdalena Wiktor, Wirginia Kukula-Koch, Anna Malm
Comparative analysis of flavonoids and phenolic acids composition, in plants of six species of Monarda from family Lamiaceae was carried out. The 70% ( v/v ) methanolic extracts of flowering herbs of Monarda citriodora Cerv. ex Lag., Monarda bradburiana L.C. Beck, Monarda didyma L., Monarda media Willd., Monarda fistulosa L. and Monarda punctata L. were analyzed for their polyphenol composition as well as antioxidant capacity and antimicrobial effect. Liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-DAD-ESI-QTOF/MS/MS) was used to identify phenolic compounds...
March 16, 2023: Pharmaceutics
https://read.qxmd.com/read/36894719/using-the-deformity-index-of-vital-structures-to-predict-outcome-of-patients-with-large-vestibular-schwannomas-after-gamma-knife-radiosurgery
#6
JOURNAL ARTICLE
Hao-Chun Chang, Weir Chiang You, Chiung-Chyi Shen, Ying Ju Chen, Ming-His Sun, Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Kuo-Chih Su, Hung-Chuan Pan
PURPOSE: Microsurgery is the mainstay of treatment for large vestibular schwannomas (VS), but the benefits of radiosurgery remain incompletely defined. Here, we aim to use automated volumetric analysis software to quantify the degree of brain stem deformity to predict long-term outcomes of patients with large VS following GKRS. METHODS: Between 2003 and 2020, 39 patients with large VS (volume > 8 cc) undergoing GKRS with a margin dose of 10-12 Gy were analyzed...
March 9, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/35901043/development-of-an-advance-directive-communication-tool-relevant-for-patients-with-advanced-cancer-in-six-european-countries-experiences-from-the-action-trial
#7
JOURNAL ARTICLE
Caroline Moeller Arnfeldt, Mogens Groenvold, Anna Thit Johnsen, Branka Červ, Luc Deliens, Lesley Dunleavy, Agnes van der Heide, Marijke C Kars, Urška Lunder, Guido Miccinesi, Kristian Pollock, Judith A C Rietjens, Jane Seymour
BACKGROUND: The ACTION trial evaluated the effect of a modified version of the Respecting Choices´ advance care planning programme in patients with advanced cancer in six European countries. For this purpose, an advance directive acceptable for all six ACTION countries to be used for documenting the wishes and preferences of patients and as a communication tool between patients, their caregivers and healthcare staff, was needed. AIM: To describe the development of a multinational cancer specific advance directive, the ´My Preferences form´, which was first based on the 2005 Wisconsin 'Physician Orders of Life Sustaining Treatment´ Form, to be used within the ACTION trial...
2022: PloS One
https://read.qxmd.com/read/35586321/%C3%AF-relationships-among-calibrachoa-fabiana-and-petunia-petunieae-tribe-solanaceae-and-a-new-generic-placement-of-argentinean-endemic-petuniapatagonica
#8
JOURNAL ARTICLE
Alejandrina Alaria, John H Chau, Richard G Olmstead, Iris E Peralta
Calibrachoa Cerv., Fabiana Ruiz & Pav., and Petunia Juss. form a clade within tribe Petunieae (Solanaceae). Phylogenetic studies of Petunieae, either as part of a family-wide analysis or focusing on the genera Calibrachoa and Petunia , have either left Fabiana unsampled or included only a single species. These studies have found conflicting relationships among the three genera with all three possible topologies obtained. Petuniapatagonica (Speg.) Millán, originally described in the genus Nierembergia Ruiz & Pav...
2022: PhytoKeys
https://read.qxmd.com/read/35522952/first-report-of-grapevine-algerian-latent-virus-in-carnation-in-new-zealand
#9
JOURNAL ARTICLE
Joe Tang, Sonia Lilly, Stella Veerakone, Deepika Kanchiraopally, Michelle Kelly, Catia Delmiglio, Jeremy R Thompson
Carnation (Dianthus caryophyllus) is a popular ornamental plant widely used as a cut flower and in landscaping. In New Zealand, several viruses are known to infect plants of the genus Dianthus: arabis mosaic virus, carnation etched ring virus (CERV), carnation latent virus, carnation mottle virus, carnation necrotic fleck virus, carnation ringspot virus, carnation vein mottle virus and cucumber mosaic virus (Veerakone et al. 2015). In October 2020, a carnation sample with leaf chlorotic spots and distortion from a home garden in Auckland, New Zealand was submitted to the Plant Health and Environment Laboratory (PHEL) for virus testing...
May 6, 2022: Plant Disease
https://read.qxmd.com/read/34677633/spinal-pathology-and-outcome-post-tha-does-segment-of-arthrodesis-matter
#10
JOURNAL ARTICLE
Tom Schmidt-Braekling, Matthew J Coyle, Johanna Dobransky, Cheryl Kreviazuk, Wade Gofton, Philippe Phan, Paul E Beaulé, George Grammatopoulos
INTRODUCTION: The presence of lumbar spine arthrodesis (SA) is associated with abnormal spinopelvic characteristics and inferior outcome post total hip arthroplasty (THA). However, whether patients with upper segment SA are also at increased risk of complications is unknown. This study aims to (1) determine if upper segment SA is associated with inferior THA outcomes; (2) assess spino-pelvic characteristics; and (3) test whether static or dynamic spinopelvic characteristics correlate with outcome post-THA...
October 22, 2021: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/33186365/advance-care-planning-in-patients-with-advanced-cancer-a-6-country-cluster-randomised-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Ida J Korfage, Giulia Carreras, Caroline M Arnfeldt Christensen, Pascalle Billekens, Louise Bramley, Linda Briggs, Francesco Bulli, Glenys Caswell, Branka Červ, Johannes J M van Delden, Luc Deliens, Lesley Dunleavy, Kim Eecloo, Giuseppe Gorini, Mogens Groenvold, Bud Hammes, Francesca Ingravallo, Lea J Jabbarian, Marijke C Kars, Hana Kodba-Čeh, Urska Lunder, Guido Miccinesi, Alenka Mimić, Polona Ozbič, Sheila A Payne, Suzanne Polinder, Kristian Pollock, Nancy J Preston, Jane Seymour, Anja Simonič, Anna Thit Johnsen, Alessandro Toccafondi, Mariëtte N Verkissen, Andrew Wilcock, Marieke Zwakman, Agnes van der Heide, Judith A C Rietjens
BACKGROUND: Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. METHODS AND FINDINGS: To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015-2018...
November 2020: PLoS Medicine
https://read.qxmd.com/read/32859636/expression-patterns-of-cd44-and-areg-under-treatment-with-selective-tyrosine-kinase-inhibitors-in-hpv-and-hpv-squamous-cell-carcinoma
#12
JOURNAL ARTICLE
Benjamin Kansy, Christoph Aderhold, Lena Huber, Sonja Ludwig, Richard Birk, Anne Lammert, Stephan Lang, Nicole Rotter, Benedikt Kramer
BACKGROUND: We investigated the expression patterns of cluster of differentiation (CD) 44 and amphiregulin (AREG), two signaling molecules essential for cell proliferation and differentiation, under the influence of selective tyrosine kinase inhibitors (TKIs) in human papillomavirus (HPV)+ and HPV- squamous carcinoma cell lines. MATERIALS AND METHODS: The protein expression of CD44 and AREG was determined by sandwich enzyme-linked immunosorbent assay in HPV- cell lines UMSCC-11A and UMSCC-14C, and HPV+ CERV-196 cells after TKI treatment...
September 2020: Cancer Genomics & Proteomics
https://read.qxmd.com/read/32649666/videogame-related-experiences-among-regular-adolescent-gamers
#13
JOURNAL ARTICLE
José Antonio Ponce-Blandón, Inocencio Espejel-Hernández, Macarena Romero-Martín, María de Las Mercedes Lomas-Campos, Nerea Jiménez-Picón, Juan Gómez-Salgado
The objective of this study was to identify the videogame-related experiences expressed by regular adolescent gamers and to explore the socio-family factors related to these experiences. A cross-sectional observational and descriptive study was carried out with a convenience sample of regular Spanish videogamers between 16 and 18 years old. To measure the use of videogames for evasion and its negative consequences, the Questionnaire of Videogame-Related Experiences (Cuestionario de Experiencias Relacionadas con Videojuegos, CERV) was used and socio-family variables collected, evaluating their relationship with the results of the CERV...
2020: PloS One
https://read.qxmd.com/read/32624592/nanoencapsulated-monarda-citriodora-cerv-ex-lag-essential-oil-as-potential-antifungal-and-antiaflatoxigenic-agent-against-deterioration-of-stored-functional-foods
#14
JOURNAL ARTICLE
Deepika, Akanksha Singh, Anand Kumar Chaudhari, Somenath Das, Nawal Kishore Dubey
In vitro antifungal activity of the essential oil from Monarda citriodora (MCEO) with possible mode of action was evaluated against A. flavus (AF-LHP-SH1) and 15 other storage molds for controlling postharvest deterioration of stored functional food samples. The chemical profiling of MCEO as done through GC-MS analysis revealed caryophyllene (19.15%) as the major component. The MCEO showed broad spectrum fungitoxicity and completely inhibited the growth of all tested molds and aflatoxin B1 (AFB1 ) production by AF-LHP-SH1 at 1...
August 2020: Journal of Food Science and Technology
https://read.qxmd.com/read/31672145/trained-facilitators-experiences-with-structured-advance-care-planning-conversations-in-oncology-an-international-focus-group-study-within-the-action-trial
#15
JOURNAL ARTICLE
M Zwakman, K Pollock, F Bulli, G Caswell, B Červ, J J M van Delden, L Deliens, A van der Heide, L J Jabbarian, H Koba-Čeh, U Lunder, G Miccinesi, C A Møller Arnfeldt, J Seymour, A Toccafondi, M N Verkissen, M C Kars
BACKGROUND: In oncology, Health Care Professionals often experience conducting Advance Care Planning (ACP) conversations as difficult and are hesitant to start them. A structured approach could help to overcome this. In the ACTION trial, a Phase III multi-center cluster-randomized clinical trial in six European countries (Belgium, Denmark, Italy, the Netherlands, Slovenia, United Kingdom), patients with advanced lung or colorectal cancer are invited to have one or two structured ACP conversations with a trained facilitator...
October 31, 2019: BMC Cancer
https://read.qxmd.com/read/31663183/coping-strategies-of-patients-with-advanced-lung-or-colorectal-cancer-in-six-european-countries-insights-from-the-action-study
#16
JOURNAL ARTICLE
Lea J Jabbarian, Ida J Korfage, Branka Červ, Johannes J M van Delden, Luc Deliens, Guido Miccinesi, Sheila Payne, Anna Thit Johnsen, Mariëtte N Verkissen, Andrew Wilcock, Agnes van der Heide, Judith A C Rietjens
OBJECTIVE: Even when medical treatments are limited, supporting patients' coping strategies could improve their quality of life. Greater understanding of patients' coping strategies, and influencing factors, can aid developing such support. We examined the prevalence of coping strategies and associated variables. METHODS: We used sociodemographic and baseline data from the ACTION trial, including measures of Denial, Acceptance, and Problem-focused coping (COPE; Brief COPE inventory), of patients with advanced cancer from six European countries...
February 2020: Psycho-oncology
https://read.qxmd.com/read/31316815/on-chip-crystallization-for-serial-crystallography-experiments-and-on-chip-ligand-binding-studies
#17
JOURNAL ARTICLE
Julia Lieske, Maximilian Cerv, Stefan Kreida, Dana Komadina, Janine Fischer, Miriam Barthelmess, Pontus Fischer, Tim Pakendorf, Oleksandr Yefanov, Valerio Mariani, Thomas Seine, Breyan H Ross, Eva Crosas, Olga Lorbeer, Anja Burkhardt, Thomas J Lane, Sebastian Guenther, Julian Bergtholdt, Silvan Schoen, Susanna Törnroth-Horsefield, Henry N Chapman, Alke Meents
Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption and shorter data collection times owing to higher hit rates. Here, a new method of on-chip crystallization is reported which allows the efficient and reproducible growth of large numbers of protein crystals directly on micro-patterned silicon chips for in-situ serial crystallography experiments...
July 1, 2019: IUCrJ
https://read.qxmd.com/read/30979589/the-mito-cerv-2-trial-a-randomized-phase-ii-study-of-cetuximab-plus-carboplatin-and-paclitaxel-in-advanced-or-recurrent-cervical-cancer
#18
RANDOMIZED CONTROLLED TRIAL
Sandro Pignata, Giovanni Scambia, Domenica Lorusso, Ugo De Giorgi, Maria Ornella Nicoletto, Rossella Lauria, Anna Maria Mosconi, Cosimo Sacco, Claudia Omarini, Pierosandro Tagliaferri, Gabriella Ferrandina, Saverio Cinieri, Antonella Savarese, Giorgio Valabrega, Carmela Pisano, Vanda Salutari, Francesco Raspagliesi, Barbara Kopf, Sabrina Chiara Cecere, Giulia Amadio, Giuseppa Maltese, Marilena Di Napoli, Stefano Greggi, Simona Signoriello, Gennaro Daniele, Alessandra Sacco, Simona Losito, Nicola Normanno, Francesco Perrone, Ciro Gallo, Maria Carmela Piccirillo
BACKGROUND: Cervical cancer cells often express Epidermal Growth Factor Receptor (EGFR). Cetuximab (CET), an anti-EGFR antibody, can be safely combined with carboplatin (C) and paclitaxel (P), a standard treatment for advanced/recurrent cervical cancer (ARCC) patients. PATIENTS AND METHODS: ARCC patients, ECOG PS ≤ 1, were randomized to CP for 6 cycles with or without CET (400 mg/m2 one week before starting CP, then 250 mg/m2 weekly) until disease progression or unacceptable toxicity...
June 2019: Gynecologic Oncology
https://read.qxmd.com/read/30962124/corrigendum-to-design-of-va-cooperative-study-591-cerv-ptsd-comparative-effectiveness-research-in-veterans-with-ptsd-contemp-clin-trials-41-2015-75-84
#19
Paula P Schnurr, Kathleen M Chard, Josef I Ruzek, Bruce K Chow, Mei-Chiung Shih, Patricia A Resick, Edna B Foa, Brian P Marx, Grant D Huang, Ying Lu
No abstract text is available yet for this article.
May 2019: Contemporary Clinical Trials
https://read.qxmd.com/read/29316357/cerebrovascular-events-in-systemic-lupus-erythematosus-results-from-an-international-inception-cohort-study
#20
MULTICENTER STUDY
John G Hanly, Qiuju Li, Li Su, Murray B Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, M A Dooley, Kristjan Steinsson, Rosalind Ramsey-Goldman, Asad A Zoma, Susan Manzi, Ola Nived, Andreas Jonsen, Munther A Khamashta, Graciela S Alarcón, Winn Chatham, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Manuel Ramos-Casals, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Soren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Chris Theriault, Vernon Farewell
OBJECTIVE: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis...
October 2018: Arthritis Care & Research
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