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https://www.readbyqxmd.com/read/28429908/pre-pregnancy-body-mass-index-as-a-predictor-of-low-birth-weight-infants-in-japan
#1
Utako Murai, Kyoko Nomura, Michiko Kido, Takeaki Takeuchi, Mitsuhiro Sugimoto, Mahbubur Rahman
BACKGROUND AND OBJECTIVES: The prevalence of low birth weight (LBW) infants in Japan has doubled in the last several decades. The objective of this study was to examine the effects of pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on LBW infants of Japanese women. METHODS AND STUDY DESIGN: This retrospective study was conducted using data on 1,336 mothers (mean age, 34.0 years)whose pre-pregnancy BMI was less than 23 kg/m2 and their singleton infants were born at full term between January and December in 2011...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429366/analysis-of-transcriptional-activities-of-angiogenic-biomarkers-during-intrauterine-complications-leading-to-preterm-birth
#2
M Rabajdová, R Dudič, P Urban, V Dudičová, P Urdzík, M Mareková
OBJECTIVE: Pre-eclampsia, growth retardation and preterm delivery are the most common reasons leading to increased maternal and perinatal mortality. The increased expression of hypoxia induced factors, such as HIF-1, triggers the overexpression of anti-angiogenic genes. The aim of this study was to determine the transcriptional activity of individual pro- and anti-angiogenic markers (VEGF, HIF-1, sEng, Flt-1, PlGF-1) in maternal blood samples from patients with spontaneous preterm labor, preterm labor in combination with pre-eclampsia and fetal growth restriction in comparison with physiologically terminated pregnancies...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28427711/maternal-and-perinatal-characteristics-of-infants-who-later-in-life-developed-multiple-sclerosis-record-linkage-study
#3
Alexander Goldacre, Julia Pakpoor, Michael Goldacre
BACKGROUND: Pre-natal and early life factors may have a role in multiple sclerosis (MS) pathogenesis in some people. However, the reporting of any influence of maternal and perinatal factors on MS risk has been limited. We aimed to study maternal and perinatal characteristics of babies who went on to develop MS. METHODS: Data were analysed from the historical Oxford Record Linkage Study dataset 1970-1989, which incorporated a specialised maternity dataset with record linkage between mother and baby, covering a population of 850,000...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28421136/time-from-pre-eclampsia-diagnosis-to-delivery-affects-future-health-prospects-of-children
#4
Birgitte Hollegaard, Jacob A Lykke, Jacobus J Boomsma
Background and objectives: Pre-eclampsia often has detrimental health effects for pregnant women and their fetuses, but whether exposure in the womb has long-term health-consequences for children as they grow up remains poorly understood. We assessed overall morbidity of children following exposure to either mild or severe pre-eclampsia up to 30 years after birth and related disease risks to duration of exposure, i.e. the time from diagnosis to delivery. Methodology: We did a registry-based retrospective cohort study in Denmark covering the years 1979-2009, using the separate diagnoses of mild and severe pre-eclampsia and the duration of exposure as predictor variables for specific and overall risks of later disease...
2017: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/28418814/ionizing-radiation-exposure-during-pregnancy-effects-on-postnatal-development-and-life
#5
Shayenthiran Sreetharan, Christopher Thome, Sujeenthar Tharmalingam, Devon E Jones, Adomas V Kulesza, Neelam Khaper, Simon J Lees, Joanna Y Wilson, Douglas R Boreham, T C Tai
Reliable human data on the effects of prenatal exposure to ionizing radiation are largely based on high-dose exposures. Exposure to low doses may produce effects that are not easily observable at birth, and may persist over the course of the offspring's postnatal life. This is important when considering fetal programing, a phenomenon characterized by changes in offspring phenotype due to a stress experienced in utero. In this review, we briefly summarize the known effects of both high- and low-dose exposure to ionizing radiation during pregnancy in humans...
April 18, 2017: Radiation Research
https://www.readbyqxmd.com/read/28411062/incidence-and-characteristics-of-positive-pressure-ventilation-delivered-to-newborns-in-a-us-tertiary-academic-hospital
#6
Dana E Niles, Courtney Cines, Elena Insley, Elizabeth E Foglia, Okan U Elci, Christiane Skåre, Theresa Olasveengen, Anne Ades, Michael Posencheg, Vinay M Nadkarni, Jo Kramer-Johansen
INTRODUCTION: The Neonatal Resuscitation Program (NRP) guidelines recommend positive pressure ventilation (PPV) in the first 60s of life to support perinatal transition in non-breathing newborns. Our aim was to describe the incidence and characteristics of newborn PPV using real-time observation in the delivery unit. METHODS: Prospective, observational, quality improvement study conducted at a tertiary academic hospital. Deliveries during randomized weekday/evening 8-h shifts were attended by a trained observer...
April 12, 2017: Resuscitation
https://www.readbyqxmd.com/read/28398697/effects-of-targeting-lower-versus-higher-arterial-oxygen-saturations-on-death-or-disability-in-preterm-infants
#7
REVIEW
Lisa M Askie, Brian A Darlow, Peter G Davis, Neil Finer, Ben Stenson, Maximo Vento, Robin Whyte
BACKGROUND: The use of supplemental oxygen in the care of extremely preterm infants has been common practice since the 1940s. Despite this, there is little agreement regarding which oxygen saturation (SpO₂) ranges to target to maximise short- or long-term growth and development, while minimising harms. There are two opposing concerns. Lower oxygen levels (targeting SpO₂ at 90% or less) may impair neurodevelopment or result in death. Higher oxygen levels (targeting SpO₂ greater than 90%) may increase severe retinopathy of prematurity or chronic lung disease...
April 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28398243/neonatal-citrulline-supplementation-and-later-exposure-to-a-high-fructose-diet-in-rats-born-with-a-low-birth-weight-a-preliminary-report
#8
Nhat-Thang Tran, Marie-Cécile Alexandre-Gouabau, Anthony Pagniez, Khadija Ouguerram, Clair-Yves Boquien, Norbert Winer, Dominique Darmaun
A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age...
April 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28397763/endoplasmic-reticulum-stress-and-homeostasis-in-reproductive-physiology-and-pathology
#9
REVIEW
Elif Guzel, Sefa Arlier, Ozlem Guzeloglu-Kayisli, Mehmet Selcuk Tabak, Tugba Ekiz, Nihan Semerci, Kellie Larsen, Frederick Schatz, Charles Joseph Lockwood, Umit Ali Kayisli
The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts directly or indirectly with several cell organelles i.e., Golgi bodies, mitochondria and proteasomes. The ER is usually associated with large numbers of attached ribosomes. During evolution, ER developed as the specific cellular site of synthesis, folding, modification and trafficking of secretory and cell-surface proteins. The ER is also the major intracellular calcium storage compartment that maintains cellular calcium homeostasis...
April 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28392200/longitudinal-growth-of-french-singleton-children-born-after-in-vitro-fertilization-and-intracytoplasmic-sperm-injection-body-mass-index-up-to-5-years-of-age
#10
L Meddeb, V Pauly, P Boyer, D Montjean, B Devictor, L Curel, P Seng, R Sambuc, M Gervoise Boyer
BACKGROUND: The literature presents conflicting results on the epigenetic effect of in vitro fertilization (IVF) on the short-term and mid-term growth of children. These contradictory results may be related to the use of heterogeneous methodologies and non-longitudinal data. The goal of this study was to compare the body mass index (BMI) of children conceived via IVF and spontaneous conception (SC) children, using longitudinal data from birth to 5 years. METHODS: This study compared 118 singleton children born after in vitro fertilization, with or without intracytoplasmic sperm injection (ICSI), selected from a pre-existing single-center cohort to 320 SC children from the same geographic area...
April 6, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28385334/live-birth-derived-from-oocyte-spindle-transfer-to-prevent-mitochondrial-disease
#11
John Zhang, Hui Liu, Shiyu Luo, Zhuo Lu, Alejandro Chávez-Badiola, Zitao Liu, Mingxue Yang, Zaher Merhi, Sherman J Silber, Santiago Munné, Michalis Konstandinidis, Dagan Wells, Taosheng Huang
Mutations in mitochondrial DNA (mtDNA) are maternally inherited and can cause fatal or debilitating mitochondrial disorders. The severity of clinical symptoms is often associated with the level of mtDNA mutation load or degree of heteroplasmy. Current clinical options to prevent transmission of mtDNA mutations to offspring are limited. Experimental spindle transfer in metaphase II oocytes, also called mitochondrial replacement therapy, is a novel technology for preventing mtDNA transmission from oocytes to pre-implantation embryos...
April 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28382052/comparative-investigation-of-indicators-of-growth-and-behavioral-disorders-in-children-with-normal-low-and-very-low-birth-weight-at-pre-school-age-in-isfahan-during-2015
#12
Marzieh Yousefi, Zahra Abdeyazdan, Soheila Ehsanpour
INTRODUCTION: Birth weight is one of the most important indicators of infant's health and could predict their health condition in future. This study was conducted to determine and compare indicators of growth [weight, height, and body mass index (BMI)] and behavioral disorders in children with normal, low, and very low birth weight at pre-school age. MATERIALS AND METHODS: In this descriptive analytical study, 236 children (126 with normal weight, 100 with low birth weight, and 10 with very low birth weight) at pre-school age were investigated in three groups...
January 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28367068/from-scientific-article-to-press-release-to-media-coverage-advocating-alcohol-abstinence-and-democratising-risk-in-a-story-about-alcohol-and-pregnancy
#13
Ellie Lee, Robbie M Sutton, Bonny L Hartley
In this article, we follow the approach taken by Riesch and Spiegalhalter in "Careless pork costs lives': Risk stories from science to press release to media' published in this journal, and offer an assessment of one example of a 'risk story'. Using content and thematic qualitative analysis, we consider how the findings of an article 'Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study' were framed in the article itself, the associated press release, and the subsequent extensive media coverage...
August 17, 2016: Health, Risk & Society
https://www.readbyqxmd.com/read/28363609/maternal-fetal-monitoring-of-opioid-exposed-pregnancies-analysis-of-a-pilot-community-based-protocol-and-review-of-the-literature
#14
Gareth Ryan, Joe Dooley, Rory Windrim, Megan Bollinger, Lianne Gerber Finn, Len Kelly
OBJECTIVES: To describe/analyse a novel, community-based prenatal monitoring protocol for opioid-exposed pregnancies developed by our centre in 2014 to optimize prenatal care for this population. A literature review of published monitoring protocols for this population is also presented. METHODS: Retrospective comparison of pre-protocol (n = 215) and post-protocol (n = 251) cohorts. Medline and Embase were searched between 2000-2016 using MeSH terms: [fetal monitoring OR prenatal care] AND [opioid-related disorders OR substance-related disorders] in Medline and [fetal monitoring OR prenatal care] AND [opiate addiction OR substance abuse] in Embase, producing 518 results...
March 28, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28358381/success-of-labor-induction-for-pre-eclampsia-at-preterm-and-term-gestational-ages
#15
C Roland, C R Warshak, E A DeFranco
OBJECTIVE: Determine the impact of gestational age (GA) on vaginal delivery following induction of labor (IOL) for pre-eclampsia, and evaluate factors that influence successful induction. STUDY DESIGN: Population-based retrospective cohort of 1 034 552 live births in Ohio (2006-2012). The rate of vaginal delivery in women with pre-eclampsia who underwent induction was calculated with 95% confidence intervals, stratified by week of GA at birth. Factors associated with the decision to undergo IOL, and success of IOL were evaluated, and multivariable logistic regression estimated the strength of association...
March 30, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28346268/long-term-recall-of-pregnancy-related-events
#16
Helen B Chin, Donna D Baird, D Robert McConnaughey, Clarice R Weinberg, Allen J Wilcox, Anne Marie Jukic
BACKGROUND: Early-life factors can be associated with future health outcomes and are often measured by maternal recall. METHODS: We used data from the North Carolina Early Pregnancy Study and Follow-up to characterize long-term maternal recall. We used data from the Early Pregnancy Study as the gold standard to evaluate the accuracy of pre-pregnancy weight, early pregnancy behaviors, symptoms and duration of pregnancy, and child's birthweight reported at follow-up, for 109 women whose study pregnancies had resulted in a live birth...
March 23, 2017: Epidemiology
https://www.readbyqxmd.com/read/28343180/oxygen-saturation-trends-in-normal-healthy-term-newborns-normal-vaginal-delivery-vs-elective-cesarean-section
#17
Rashi Bhargava, Madhu Mathur, Jyoti Patodia
OBJECTIVES: To study the normal oxygen saturation trends and fetomaternal correlates in healthy term newborns within 30 min of life born by normal vaginal delivery (NVD) and elective cesarean section (CS). MATERIALS AND METHODS: A cross-sectional study was conducted on 200 healthy term newborns born by NVD and elective CS at a tertiary care centre. Routine care as per the Neonatal Resuscitation Program (NRP) 2015 (Wyckoff MH, Aziz K, Escobedo MB, Kapadia VS, Kattwinkel J, Perlman JM, et al...
March 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28343094/effects-of-posted-point-of-sale-warnings-on-alcohol-consumption-during-pregnancy-and-on-birth-outcomes
#18
Gulcan Cil
In 23 states and Washington D.C., alcohol retailers are required by law to post alcohol warning signs (AWS) that warn against the risks of drinking during pregnancy. Using the variation in the adoption of these laws across states and within states over time, I find a statistically significant reduction in prenatal alcohol use associated with AWS. I then use this plausibly exogenous change in drinking behavior to establish a causal link between prenatal alcohol exposure and birth outcomes. I find that AWS laws are associated with decreases in the odds of very low birth weight and very pre-term birth...
March 18, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28338584/spring-assisted-cranioplasty-for-the-correction-of-non-syndromic-scaphocephaly-a-quantitative-analysis-of-100-consecutive-cases
#19
W Rodgers, G E Glass, S Schievano, A Borghi, N Rodriguez-Florez, A Tahim, F Angullia, W Breakey, P Knoops, M Tenhagen, J O'Hara, A Ponniah, G James, D J Dunaway, Nuo Jeelani
BACKGROUND: Spring-assisted cranioplasty has been proposed as an alternative to total calvarial remodelling for sagittal craniosynostosis. Advantages include its minimally invasive nature, reduced morbidity and hospital stay. Potential drawbacks include the need for a second procedure for removal and the lack of published long-term follow-up. We present a single institution experience of 100 consecutive cases using a novel spring design. METHODS: All patients treated at our institution between April 2010 and September 2014 were evaluated retrospectively...
March 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28333279/inhibition-of-pim1-kinase-attenuates-inflammation-induced-pro-labour-mediators-in-human-fetal-membranes-in-vitro
#20
Ratana Lim, Gillian Barker, Martha Lappas
STUDY QUESTION: Does proviral integration site for Moloney murine leukemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery? SUMMARY ANSWER: PIM1 kinase plays a critical role in fetal membranes in regulating pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY: Infection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes...
March 9, 2017: Molecular Human Reproduction
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