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https://www.readbyqxmd.com/read/29144056/oropharyngeal-dysphagia-profiles-in-individuals-with-oculopharyngeal-muscular-dystrophy
#1
L C Tabor, E K Plowman, C Romero-Clark, S Youssof
BACKGROUND: Although dysphagia represents a hallmark manifestation of oculopharyngeal muscular dystrophy (OPMD), limited knowledge exists regarding the underlying nature of oropharyngeal swallowing impairments in this patient population. We aimed to delineate global pharyngeal dysphagia profiles in OPMD and identify the prevalence and physiologic associations of impairments in swallowing safety and efficiency. METHODS: Twenty-two individuals with OPMD completed a videofluoroscopic swallowing evaluation...
November 16, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29143399/buprenorphine-naloxone-treatment-responses-differ-between-young-adults-with-heroin-and-prescription-opioid-use-disorders
#2
Mauricio Romero-Gonzalez, Abtin Shahanaghi, Gregory J DiGirolamo, Gerardo Gonzalez
BACKGROUND AND OBJECTIVES: Opioid use disorder among young adults is rising sharply with an increase in morbidity and mortality. This study examined differences in treatment response to a fixed dose of buprenorphine-naloxone between heroin (HU) and prescriptions opioids (POU) users. METHODS: Eighty opioid dependent young adults (M = 22 years) were treated with buprenorphine-naloxone 16-4 mg/day for 8 weeks. Differences between HU (N = 17) and POU (N = 63) on changes in weekly opioid use, opioid craving, withdrawal, and depression symptoms were analyzed with mixed-effects regression models...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29143244/correction-to-the-role-of-nuclear-medicine-in-assessments-of-cardiac-dyssynchrony
#3
Masanao Naya, Osamu Manabe, Kazuhiro Koyanagawa, Nagara Tamaki
Some of the values in Table 3 of the original publication inadvertently contained discrepancies with the literature from which they were taken. A corrected version of Table 3 can be found below; the values which have been corrected now appear in bold text (row: Romero-Farina G).
November 15, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29143170/circumferential-strain-acquired-by-cmr-early-after-acute-myocardial-infarction-adds-incremental-predictive-value-to-late-gadolinium-enhancement-imaging-to-predict-late-myocardial-remodeling-and-subsequent-risk-of-sudden-cardiac-death
#4
Anthony A Holmes, Jorge Romero, Jeffrey M Levsky, Linda B Haramati, Newton Phuong, Leila Rezai-Gharai, Stuart Cohen, Lina Restrepo, Luis Ruiz-Guerrero, John D Fisher, Cynthia C Taub, Luigi Di Biase, Mario J Garcia
PURPOSE: Late adverse myocardial remodeling after acute myocardial infarction (AMI) is strongly associated with sudden cardiac death (SCD). Cardiac magnetic resonance (CMR) performed early after AMI can predict late remodeling and SCD risk with moderate accuracy. This study assessed the ability of CMR-measured circumferential strain (CS) to add incremental predictive information to late gadolinium enhancement (LGE). METHODS: Patients with an AMI and LVEF < 50% were screened for inclusion...
November 15, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29142972/a-drug-development-tool-for-trial-enrichment-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#5
Ronald D Perrone, Mohamad-Samer Mouksassi, Klaus Romero, Frank S Czerwiec, Arlene B Chapman, Berenice Y Gitomer, Vicente E Torres, Dana C Miskulin, Steve Broadbent, Jean F Marier
Introduction: Total kidney volume (TKV) is a promising imaging biomarker for tracking and predicting the natural history of patients with autosomal dominant polycystic kidney disease. Methods: A drug development tool was developed by linking longitudinal TKV measurements to the probability of a 30% decline of estimated glomerular filtration rate (eGFR) or end-stage renal disease. Drug development tools were developed based on observational data collected over multiple decades for an eGFR decline and end-stage renal disease in 641 and 866 patients with autosomal dominant polycystic kidney disease, respectively...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142971/total-kidney-volume-is-a-prognostic-biomarker-of-renal-function-decline-and-progression-to-end-stage-renal-disease-in%C3%A2-patients-with-autosomal-dominant-polycystic-kidney-disease
#6
Ronald D Perrone, Mohamad-Samer Mouksassi, Klaus Romero, Frank S Czerwiec, Arlene B Chapman, Berenice Y Gitomer, Vicente E Torres, Dana C Miskulin, Steve Broadbent, Jean F Marier
Introduction: Autosomal dominant polycystic kidney disease is the most common hereditary kidney disease. TKV is a promising imaging biomarker for tracking and predicting the natural history of autosomal dominant polycystic kidney disease. The prognostic value of TKV was evaluated, in combination with age and eGFR, for the outcomes of 30% decline in eGFR and progression to ESRD. Observational data including 2355 patients with TKV measurements were available. Methods: Multivariable Cox models were developed to assess the prognostic value of age, TKV, height-adjusted TKV, eGFR, sex, race, and genotype for the probability of a 30% decline in eGFR or ESRD...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142508/proteomic-characterisation-of-bovine-and-avian-purified-protein-derivatives-and-identification-of-specific-antigens-for-serodiagnosis-of-bovine-tuberculosis
#7
José Antonio Infantes-Lorenzo, Inmaculada Moreno, María de Los Ángeles Risalde, Álvaro Roy, Margarita Villar, Beatriz Romero, Nieves Ibarrola, José de la Fuente, Eugenia Puentes, Lucía de Juan, Christian Gortázar, Javier Bezos, Lucas Domínguez, Mercedes Domínguez
Background: Bovine purified protein derivative (bPPD) and avian purified protein derivative (aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about their qualitative and quantitative characteristics, which makes their standardisation difficult. In addition, bPPD can give false-positive tuberculosis results because of sequence homology between Mycobacterium bovis (M. bovis) and M. avium proteins. Thus, the objective of this study was to carry out a proteomic characterisation of bPPD, aPPD and an immunopurified subcomplex from bPPD called P22 in order to identify proteins contributing to cross-reactivity among these three products in tuberculosis diagnosis...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/29141083/vegetating-darier-disease-treated-with-botulinum-toxin
#8
Lidia Ossorio-García, Cristina Collantes-Rodríguez, Isabel Villegas-Romero, Mario Linares-Barrios
No abstract text is available yet for this article.
November 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29139224/a-polyelectrolyte-multilayer-platform-for-investigating-growth-factor-delivery-modes-in-human-liver-cultures
#9
Christine Lin, Raimundo Romero, Lioudmila V Sorokina, Kimberly R Ballinger, Laura W Place, Matt J Kipper, Salman R Khetani
Polyelectrolyte multilayers (PEMs) of chitosan and heparin are useful for mimicking growth factor (GF) binding to extracellular matrix (ECM) as in vivo. Here, we developed a PEM platform for delivering bound/adsorbed GFs to monocultures of primary human hepatocytes (PHHs) and PHH/non-parenchymal cell (NPC) co-cultures, which are useful for drug development and regenerative medicine. The effects of ECM protein coating (collagen I, fibronectin, and Matrigel®) and terminal PEM layer on PHH attachment/functions were determined...
November 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29138750/markers-of-alzheimer-s-disease-in-primary-visual-cortex-in-normal-aging-in-mice
#10
Luis Fernando Hernández-Zimbrón, Montserrat Perez-Hernández, Abigail Torres-Romero, Elisa Gorostieta-Salas, Roberto Gonzalez-Salinas, Rosario Gulias-Cañizo, Hugo Quiroz-Mercado, Edgar Zenteno
Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-β peptide 1-42 (Aβ42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of the brain and, more recently reported, in the visual cortex. Recently, Aβ42 peptide overproduction has been involved in visual loss. Similar to AD, in normal aging, there is a significant amyloid deposition related to the overactivation of the aforementioned mechanisms. However, the mechanisms associated with visual loss secondary to age-induced visual cortex affectation are not completely understood...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29138252/apical-polarization-and-lumenogenesis-the-apicosome-sheds-new-light
#11
Alejandra I Romero-Morales, Natalya A Ortolano, Vivian Gama
Establishment of apico-basal polarity is critical for the lumenal epiblast-like morphogenesis of human pluripotent stem cells (hPSCs). In this issue, Taniguchi et al. (2017. J Cell Biol. https://doi.org/10.1083.jcb201704085) describe a structure called the apicosome, generated in single hPSCs, that allows them to self-organize and form the lumenal epiblast-like stage.
November 14, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29137638/virus-triggered-exacerbation-in-allergic-asthmatic-children-neutrophilic-airway-inflammation-and-alteration-of-virus-sensors-characterize-a-subgroup-of-patients
#12
Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq, Philippe Gosset
BACKGROUND: Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this defect remain unclear. The objective of this study was to compare in virus-infected and not-infected allergic asthmatic children, aged 6 to 16 years, admitted to hospital for a severe exacerbation, the innate immune response and especially the expression of pattern recognition receptor (PRR) and their function...
November 14, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29136613/increasing-incidence-and-prevalence-of-multiple-sclerosis-in-puerto-rico-2013-2016
#13
Angel Chinea, Carlos F Ríos-Bedoya, Ivonne Vicente, Cristina Rubí, Guillermo García, Ana Rivera, Astrid Díaz, Eduardo Estades Romero, Yatzka Hernández Silvestrini, Yaritza Díaz
BACKGROUND: The incidence of multiple sclerosis (MS) has been increasing worldwide over the past decades. However, this upward trend has not been examined at the country level in Latin America and the Caribbean (LAC). The aims of this study are to examine trends of MS incidence over 4 years and to provide age- and gender-standardized incidence rate estimates for a Caribbean island. METHODS: Data from the Puerto Rico (PR) MS Foundation's registry was used to identify all newly diagnosed MS cases between 2013 and 2016...
November 14, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29134958/immunotherapy-nice-to-see-you-evolving-mhc-i-peptide-presentation
#14
Diana Romero
No abstract text is available yet for this article.
November 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29132968/canaliculitis-due-to-gemella-haemolysans-in-a-single-isolate
#15
J L Romero-Trevejo, J Somavilla-Lupiáñez
CASE REPORT: An 84 year-old woman was referred for evaluation of a painless swelling with small purulent discharge in her left upper canaliculus, and an associated epiphora of one-month duration. The patient was diagnosed with acute primary canaliculitis. She was treated with topical and oral antibiotics, as well as topical corticoids for three months, with little response. Surgical treatment with left upper canaliculotomy and curettage was then performed, and Gemella haemolysans was identified from the curetted material...
November 10, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29132933/long-term-follow-up-of-the-advance-%C3%A2-advancexp-%C3%A2-sling-what-are-the-surgeons-impressions-what-are-the-patients
#16
A Romero Hoyuela, L Reina Alcaina, E Izquierdo Morejon, A Rosino Sanchez, C Carrillo George, A Rivero Guerra, I Barcelo Bayonas, A Pardo Martinez, V Muñoz Guillermo, B Pietricica, T Fernandez Aparicio, G Hita Villaplana, B Miñana Lopez
OBJECTIVES: To analyse the safety, efficacy and quality of life of patients with male stress urinary incontinence after radical prostatectomy treated with the AdVance(®) and AdvanceXP(®) slings. PATIENTS AND METHOD: The study included 92 patients with stress urinary incontinence after radical prostatectomy treated with the AdVance(®) and AdVanceXP(®) sling between May 2008 and December 2015. A perineal repositioning test was performed in all cases with sphincter coaptation of≥1...
November 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29132932/apoptotic-effect-as-biomarker-of-disease-severity-and-follow-up-in-interstitial-cystitis
#17
C Di Capua-Sacoto, A Sanchez-Llopis, J E Oconnor, A Martinez-Romero, J L Ruiz-Cerdá
OBJECTIVE: To determine whether the apoptotic effect test could serve as a biomarker of severity in bladder pain syndrome/interstitial cystitis. MATERIAL AND METHODS: A prospective study was conducted between January 2010 and January 2015, which included 57 patients diagnosed with interstitial cystitis and 49 diagnosed with chronic pelvic pain of gynaecological origin. The urine was exposed to cell cultures, and the urine's capacity for inducing apoptosis in the cultures was analysed...
November 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29132852/topical-15-resorcinol-for-hidradenitis-suppurativa-an-uncontrolled-prospective-trial-with-clinical-and-ultrasonographic-follow-up
#18
José C Pascual, Belén Encabo, Rosa F Ruiz de Apodaca, David Romero, Juan Selva, Gregor B Jemec
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29132400/hospitalization-causes-and-outcomes-in-hiv-patients-in-the-late-antiretroviral-era-in-colombia
#19
María Fernanda Álvarez Barreneche, Carlos Andrés Restrepo Castro, Alicia Hidrón Botero, Juan Pablo Villa Franco, Ivan Mauricio Trompa Romero, Laura Restrepo Carvajal, Alejandro Eusse García, Adriana Ocampo Mesa, Lina María Echeverri Toro, Glenys Patricia Porras Fernández de Castro, Jaime Mauricio Ramírez Rivera, Carlos Andrés Agudelo Restrepo
BACKGROUND: Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This study describes the patient population, admission diagnosis and hospital course of HIV patients in Colombia in the ART era. METHODS: Patients admitted with HIV/AIDS at six hospitals in Medellin, Colombia between August 1, 2014 and July 31, 2015 were included...
November 13, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29131211/pharmaco-genomic-investigations-of-organo-iridium-anticancer-complexes-reveal-novel-mechanism-of-action
#20
Jessica M Hearn, George M Hughes, Isolda Romero-Canelón, Alison F Munro, Belén Rubio-Ruiz, Zhe Liu, Neil O Carragher, Peter J Sadler
Resistance to platinum drugs (used in >50% of cancer chemotherapies) is a clinical problem. Other precious metal complexes with distinct mechanisms of action might overcome this. Half-sandwich organometallic complexes containing arene or cyclopentadienyl (Cp) ligands show promise. We screened two iridium(iii) complexes [Ir(Cp(Xbiph))(ppy)Cl] (ZL49, 1, ppy = phenylpyridine) and [Ir(Cp(Xph))(azpyNMe2)Cl]PF6 (ZL109, 2, azpyNMe2 = N,N-dimethylphenylazopyridine) in 916 cancer cell lines from 28 tissue types. On average, complex 2 was 78× more potent than 1, 36× more active than cisplatin (CDDP), and strongly active (nanomolar) in patient-derived ovarian cancer cell lines...
November 13, 2017: Metallomics: Integrated Biometal Science
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