keyword
https://read.qxmd.com/read/38547201/similarity-and-dissimilarity-in-alterations-of-the-gene-expression-profile-associated-with-inhalational-anesthesia-between-sevoflurane-and-desflurane
#1
JOURNAL ARTICLE
Takehiro Nogi, Kousuke Uranishi, Ayumu Suzuki, Masataka Hirasaki, Tina Nakamura, Tomiei Kazama, Hiroshi Nagasaka, Akihiko Okuda, Tsutomu Mieda
Although sevoflurane is one of the most commonly used inhalational anesthetic agents, the popularity of desflurane is increasing to a level similar to that of sevoflurane. Inhalational anesthesia generally activates and represses the expression of genes related to xenobiotic metabolism and immune response, respectively. However, there has been no comprehensive comparison of the effects of sevoflurane and desflurane on the expression of these genes. Thus, we used a next-generation sequencing method to compare alterations in the global gene expression profiles in the livers of rats subjected to inhalational anesthesia by sevoflurane or desflurane...
2024: PloS One
https://read.qxmd.com/read/38546535/nk1-tachykinin-receptor-antagonist-treatment-reduces-cerebral-edema-and-intracranial-pressure-in-an-ovine-model-of-ischemic-stroke
#2
JOURNAL ARTICLE
Annabel J Sorby-Adams, Oana C Marian, Isabella M Bilecki, Levi E Elms, Nawaf Yassi, Rebecca J Hood, Janet K Coller, Shannon M Stuckey, W Taylor Kimberly, Tracy D Farr, Anna V Leonard, Emma Thornton, Robert Vink, Renée J Turner
Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 tachykinin receptor (NK1-R), with administration of an NK1-R antagonist shown to ameliorate BBB dysfunction and cerebral edema in rodent and permanent ovine stroke models. Given the importance of reperfusion in clinical stroke, this study examined the efficacy of NK1-R antagonist treatment in reducing cerebral edema and ICP in an ovine model of transient middle cerebral artery occlusion (tMCAo)...
March 28, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38546072/integrative-bioinformatics-analysis-reveals-potential-target-genes-and-pten-signaling-in-breast-cancer-and-effect-of-zingiber-officinale-ginger-and-allium-sativum-garlic-extract-on-it
#3
JOURNAL ARTICLE
Katayoon Sheybatzadeh, Seyed Ali Asghar Moshtaghie, Kahin Shahanipour, Fereshteh Golab
INTRODUCTION: Breast cancer is the most common type of cancer in women. The construction of a competing gene network is an important step in the identification of the role of hub genes in breast cancers. In the current research, we used a number of bioinformatics tools to construct this network in breast cancer and investigated the combined effect of garlic and ginger on mice model of breast cancer. MATERIALS AND METHODS: We chose female mice weighing 18-20 g that were divided into 7 groups including; the cancer group receiving normal saline, different doses of ginger extract (100 and 500 mg/kg), different doses of garlic (50 and 100 mg/kg), tamoxifen (10 mg/ kg) and simultaneous garlic (100 mg/kg) and ginger (500 mg/kg) for 3 weeks intraperitoneal...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38545055/comparison-of-micro-ct-image-enhancement-after-use-of-different-vascular-casting-agents
#4
JOURNAL ARTICLE
Ryan Margolis, Brian Merlo, Dara Chanthavisay, Chastity Chavez, Brian Trinh, Junjie Li
BACKGROUND: Microvascular visualization is crucial in understanding the mechanisms of several pathologies. For instance, visualization of the tumor microenvironment is important in understanding angiogenesis and role in cancer progression. Visualization would provide insights to cancer diagnosis, predicting metastatic growth, and evaluating therapeutic protocols. Similarly, understanding the microvascular network could be beneficial for study of degenerative diseases and tissue repair...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38544650/epidural-anesthesia-for-neuromyelitis-optica-in-obstetrics-a-case-report-and-literature-review
#5
Aliki Tympa Grigoriadou, Thalis Asimakopoulos, Christina Orfanou, Aikaterini Melemeni, Athanasia Tsaroucha
Neuromyelitis optica (NMO), also known as Devic disease, poses unique challenges in obstetrical anesthesia, with limited research available. This case report presents the anesthetic management of a 43-year-old gravida 2 para 1 (G2P1) woman with NMO undergoing labor induction at 39 weeks of gestation. Having received uneventful epidural labor analgesia in her first pregnancy, she faced the delicate decision of neuraxial anesthesia in light of her NMO diagnosis, which was made following her initial pregnancy...
February 2024: Curēus
https://read.qxmd.com/read/38544610/thyroid-lobectomy-under-local-anesthesia-before-lung-transplantation-owing-to-diffuse-panbronchiolitis-a-case-report
#6
Tsuyoshi Kojima, Yo Kishimoto, Keigo Honda, Atsushi Suehiro, Koichi Omori
We herein report a case of thyroid lobectomy performed under local anesthesia for thyroid cancer in a patient who was at a high risk for general anesthesia due to diffuse panbronchiolitis. Although thyroid surgery has been performed in the past under local anesthesia in low-risk patients, thyroid surgery is now rarely performed under local anesthesia. If they are performed, thyroid surgery under local anesthesia is usually performed under monitored anesthesia care; sedation is considered safe and does not cause discomfort to patients...
February 2024: Curēus
https://read.qxmd.com/read/38543149/a-common-neuronal-ensemble-in-the-lateral-habenula-regulates-ciprofol-anesthesia-in-mice
#7
JOURNAL ARTICLE
Kang Zhou, Lin-Chen Zhang, He Zhu, Bei Wen, Jia-Li Tang, Ping-Chuan Yuan, A-Fang Zhu, Yu-Guang Huang
General anesthetics were first used over 170 years ago; however, the mechanisms of how general anesthetics induce loss of consciousness (LOC) remain unclear. Ciprofol, a novel intravenous anesthetic, has been developed by incorporating cyclopropyl into the chemical structure of propofol. This modification offers the benefits of rapid onset and minimal injection pain. Recent studies have revealed that the glutamatergic neurons of the lateral habenula (LHb) play a crucial role in modulating the LOC induced by propofol and sevoflurane...
March 11, 2024: Pharmaceuticals
https://read.qxmd.com/read/38541844/evaluating-glicopro-tear-substitute-derived-from-helix-aspersa-snail-mucus-in-alleviating-severe-dry-eye-disease-a-first-in-human-study-on-corneal-esthesiometry-recovery-and-ocular-pain-relief
#8
JOURNAL ARTICLE
Antonio Ballesteros-Sánchez, José-María Sánchez-González, Giovanni Roberto Tedesco, Carlos Rocha-de-Lossada, Gianluca Murano, Antonio Spinelli, Cosimo Mazzotta, Davide Borroni
Background: To evaluate the effects of 10% GlicoPro tear substitute therapy in patients with severe dry eye disease (DED). Methods: In this prospective longitudinal study, 30 individuals receiving 10% GlicoPro four times daily for DED were evaluated. The ocular surface disease index (OSDI) questionnaire, average non-invasive break-up time (A-NIBUT), non-anesthetic and anesthetic corneal esthesiometry (CE), ocular pain, and the presence of conjunctivochalasis (CCH) were used as clinical endpoints. Treatment compliance using dosing diaries and AEs was assessed...
March 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541784/clinical-efficacy-and-tolerability-of-a-new-experimental-mucoadhesive-patch-for-topical-anesthesia-of-oral-mucosa-in-pediatric-dentistry
#9
JOURNAL ARTICLE
Gianmaria Fabrizio Ferrazzano, Giuseppe Di Fabio, Sara Caruso, Roberto Gatto, Varinder Goyal, Silvia Caruso
Background : The injection of local anesthetics is the procedure that still causes the most fear and anxiety in a dental session; to minimize this problem, we can use topical anesthesia. The aim of this study is to analyze the tolerability and the clinical efficacy in the control of pain, during the subsequent injection of the local anesthetic, of an experimental anesthetic patch with a new formulation, which was previously tested in gel formula. Methods : A total of 150 children, aged 4 to 9 years, were included in the study...
March 8, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541084/caesarean-delivery-a-narrative-review-on-the-choice-of-neuraxially-administered-opioid-and-its-implications-for-the-multimodal-peripartum-pain-concept
#10
REVIEW
Mark Ulrich Gerbershagen, Hanaa Baagil
Nowadays, obstetrical anesthesia-related mortality is a very rare complication in industrialized countries. The recommended choice of intrathecal opioid for spinal anesthesia in the context of a multimodal peripartum pain management concept is discussed in this narrative review. Nowadays, there is a consensus that a perioperative multimodal pain concept should be used for caesarean delivery. This pain concept should include neuraxial opioids for spinal anesthesia, acetaminophen, NSAIDs, intravenous dexamethasone, and postoperative local or regional anesthetic procedures...
February 21, 2024: Medicina
https://read.qxmd.com/read/38540293/comparison-of-intact-fish-skin-graft-and-allograft-as-temporary-coverage-for-full-thickness-burns-a-non-inferiority-study
#11
JOURNAL ARTICLE
Randolph Stone, Emily C Saathoff, David A Larson, John T Wall, Nathan A Wienandt, Skuli Magnusson, Hilmar Kjartansson, Robert J Christy, Shanmugasundaram Natesan
The extent and depth of burn injury may mandate temporary use of cadaver skin (allograft) to protect the wound and allow the formation of granulation tissue while split-thickness skin grafts (STSGs) are serially harvested from the same donor areas. However, allografts are not always available and have a high cost, hence the interest in identifying more economical, readily available products that serve the same function. This study evaluated intact fish skin graft (IFSG) as a temporary cover to prepare the wound bed for STSG application...
March 18, 2024: Biomedicines
https://read.qxmd.com/read/38540122/ribonucleic-acid-sequencing-reveals-the-upregulation-and-resolution-of-inflammation-and-extracellular-matrix-remodeling-in-lidocaine-treated-human-acute-monocytic-leukemia-cell-line-thp-1
#12
JOURNAL ARTICLE
Sheng-Wei Feng, Wei-Chun Lin, I-Ta Lee, Sheng-Dean Luo, Ching-Shuen Wang
Lidocaine, a local anesthetic widely used in dentistry, is esteemed for its efficacy and safety. Recent research reveals its additional role in modulating the immune system, and particularly in reducing inflammation crucial for protecting tooth-supporting tissues. Notably, monocytes and macrophages, essential cellular components overseeing various physiological and pathological processes, stand as potential mediators of lidocaine's effects. Therefore, this study aimed to investigate how lidocaine influences cell behavior using RNA sequencing...
February 23, 2024: Biomedicines
https://read.qxmd.com/read/38540075/assessment-of-the-effective-tissue-concentrations-of-injectable-lidocaine-and-a-lidocaine-impregnated-latex-band-for-castration-in-calves
#13
JOURNAL ARTICLE
Joseph A Ross, Steven M Roche, Kendall Beaugrand, Crystal Schatz, Ann Hammad, Brenda J Ralston, Andrea M Hanson, Nicholas Allan, Merle Olson
This study aimed to assess the effective tissue concentrations of the current standard of care for pain mitigation in calves during castration (injectable lidocaine) and to assess the ability of a lidocaine-loaded elastration band (LLB) to deliver effective concentrations into the scrotal tissue over time. This study comprised two different trials: (1) effective concentrations of injectable lidocaine in the scrotal tissue; and (2) the in vivo delivery of effective concentrations of lidocaine from LLBs placed on the calf scrotums...
March 21, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539920/correlation-of-blood-hemoglobin-values-with-non-invasive-co-oximetry-measurement-of-sphb-in-dogs-undergoing-elective-ovariohysterectomy
#14
JOURNAL ARTICLE
María Fernanda Espinosa-Morales, Agatha Elisa Miranda-Cortés, Daniel Mota-Rojas, Alejandro Casas-Alvarado, Alejandro Jiménez-Yedra, Alicia Pamela Pérez-Sánchez, Ismael Hernández-Ávalos
Cardiovascular function monitoring has been suggested as a key parameter to determine patient stability during the anesthetic process. However, the use of pulse co-oximetry has been suggested as a technology to complement the monitoring of this system as a direct way to assess hemoglobin (Hb) blood concentration. Therefore, this study aimed to correlate and determine the measurement bias between Hb blood levels with continuously determined blood hemoglobin concentration (SpHb) and arterial oxygen content values (SpOC), both obtained by noninvasive co-oximetry in dogs undergoing elective ovariohysterectomy (OVH)...
March 7, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539354/acute-and-persistent-postoperative-functional-decline-in-children-with-severe-neurological-impairment-a-qualitative-exploratory-study
#15
JOURNAL ARTICLE
Liisa Holsti, Sarah England, Mackenzie Gibson, Bethany McWilliams, Anne-Mette Hermansen, Harold Siden
BACKGROUND: Children with severe neurologic impairment (SNI) regularly require major surgery to manage their underlying conditions. Anecdotal evidence suggests that children with SNI experience unexpected and persistent postoperative functional changes long after the postoperative recovery period; however, evidence from the perspective of caregivers is limited. The purpose of the study was to explore the functional postoperative recovery process for children with SNI. METHODS: Eligible participants were English-speaking caregivers of children with SNI between 6 months and 17 years who were nonverbal, Gross Motor Function Classification Scale level IV/V, and who had surgery/procedure requiring general anesthetic at a tertiary children's hospital between 2012 and 2022...
March 7, 2024: Children
https://read.qxmd.com/read/38539087/accelerated-lymph-flow-from-infusion-of-crystalloid-fluid-during-general-anesthesia
#16
JOURNAL ARTICLE
Robert G Hahn
BACKGROUND: Kinetic analysis of crystalloid fluid yields a central distribution volume (Vc ) of the same size as the expected plasma volume (approximately 3 L) except during general anesthesia during which Vc might be only half as large. The present study examined whether this difference is due to influence of the intravascular albumin balance. METHODS: A population volume kinetic analysis according to a three-compartment model was performed based on retrospective data from 160 infusion experiments during which 1-2...
March 27, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38539078/prevention-of-postoperative-nausea-and-vomiting-after-orthognathic-surgery-a-scoping-review
#17
JOURNAL ARTICLE
Peng-Fei Gao, Le Zhao, Shi-Yue Li, Yue Li, Ming-Kai Chen, Jing Fu, Yang Ji
INTRODUCTION: Postoperative nausea and vomiting (PONV) is one of the most common adverse events following orthognathic surgery. It's a distressing feeling for patients and continues to be the cause of postoperative complications such as bleeding, delayed healing, and wound infection. This scoping review aims to identify effective PONV prophylaxis strategies during orthognathic surgery that have emerged in the past 15 years. METHODS: We searched Pubmed, Cochrane Controlled Register of Trials, and Embase from 2008 to May 2023...
March 28, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38539076/the-value-of-local-dexmedetomidine-as-an-adjuvant-to-ultrasound-guided-wide-awake-local-anesthesia-no-tourniquet-walant-in-flexor-tendon-repair-surgeries-a-randomized-controlled-trial
#18
JOURNAL ARTICLE
Mahmoud Mohammed Alseoudy, Elsayed Mohamed Abdelkarime, Khaled Nour, May Elsherbiny Badr
BACKGROUND: The Wide-Awake Local Anesthesia No Tourniquet (WALANT) technique allows intraoperative motor assessment of tendon repair integrity of the hand compared with general anesthesia or brachial plexus block. No studies have tested the effect of adding dexmedetomidine to lidocaine on the analgesic properties of the WALANT technique, which is the aim of our study. METHODS: A total of 128 patients aged more than 18 years were scheduled for surgical flexor tendon injury repair using WALANT technique...
March 27, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38539065/thoracolumbar-interfascial-plane-tlip-block-verses-other-paraspinal-fascial-plane-blocks-and-local-infiltration-for-enhanced-pain-control-after-spine-surgery-a-systematic-review
#19
Tarika D Patel, Meagan N McNicholas, Peyton A Paschell, Paul M Arnold, Cheng-Ting Lee
Spinal surgeries are accompanied by excessive pain due to extensive dissection and muscle retraction during the procedure. Thoracolumbar interfascial plane (TLIP) blocks for spinal surgeries are a recent addition to regional anesthesia to improve postoperative pain management. When performing a classical TLIP (cTLIP) block, anesthetics are injected between the muscle (m.) multifidus and m. longissimus. During a modified TLIP (mTLIP) block, anesthetics are injected between the m. longissimus and m. iliocostalis instead...
March 28, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38538813/new-technologies-developed-for-treatment-of-premature-ejaculation
#20
REVIEW
Arik Shechter, Ilan Gruenwald
Premature ejaculation (PE), lifelong and acquired, is the most common male sexual disorder, with serious impacts on the patient and his partner's quality of life, sexual well-being, and psychosocial health. The most popular treatment options are on-demand topical anesthetics and off-label daily or on-demand selective serotonin reuptake inhibitors (SSRIs), followed by behavioral therapy. While SSRI treatments are reportedly safe, they are associated with limited efficacy and provide only a temporary delay in ejaculation latency time...
March 27, 2024: International Journal of Impotence Research
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