Annabel J Sorby-Adams, Oana C Marian, Isabella M Bilecki, Levi E Elms, Nawaf Yassi, Rebecca J Hood, Janet K Coller, Shannon M Stuckey, W Taylor Kimberly, Tracy D Farr, Anna V Leonard, Emma Thornton, Robert Vink, Renée J Turner
Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 tachykinin receptor (NK1-R), with administration of an NK1-R antagonist shown to ameliorate BBB dysfunction and cerebral edema in rodent and permanent ovine stroke models. Given the importance of reperfusion in clinical stroke, this study examined the efficacy of NK1-R antagonist treatment in reducing cerebral edema and ICP in an ovine model of transient middle cerebral artery occlusion (tMCAo)...
March 28, 2024: Journal of Cerebral Blood Flow and Metabolism