Srivatsan Parthasarathy, Pradtahna Saenjamsai, Hongping Hao, Anna Ferkul, Jessica J Pfannenstiel, Ellen L Suder, Daniel S Bejan, Yating Chen, Nancy Schwarting, Masanori Aikawa, Elke Muhlberger, Robin C Orozco, Christopher S Sullivan, Michael S Cohen, David J Davido, Adam J Hume, Anthony R Fehr
UNLABELLED: PARP14 is a 203 kDa multi-domain protein that is primarily known as an ADP-ribosyltransferase, and is involved in a variety of cellular functions including DNA damage, microglial activation, inflammation, and cancer progression. In addition, PARP14 is upregulated by interferon (IFN), indicating a role in the antiviral response. Furthermore, PARP14 has evolved under positive selection, again indicating that it is involved in host-pathogen conflict. We found that PARP14 is required for increased IFN-I production in response to coronavirus infection lacking ADP-ribosylhydrolase (ARH) activity and poly(I:C), however, whether it has direct antiviral function remains unclear...
April 26, 2024: bioRxiv