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https://www.readbyqxmd.com/read/28922800/changes-in-fibre-adherent-and-fluid-associated-microbial-communities-and-fermentation-profiles-in-the-rumen-of-cattle-fed-diets-differing-in-hay-quality-and-concentrate-amount
#1
Fenja Klevenhusen, Renee M Petri, Maria-Theresia Kleefisch, Ratchaneewan Khiaosa-Ard, Barbara U Metzler-Zebeli, Qendrim Zebeli
The rumen microbiota enable important metabolic functions to the host cattle. Feeding of starch-rich concentrate feedstuffs to cattle has been demonstrated to increase the risk of metabolic disorders and to significantly alter the rumen microbiome. Thus, alternative feeding strategies like the use of high-quality hay, rich in sugars, as an alternative energy source need to be explored. The aim of this study was to investigate changes in rumen microbial abundances in the liquid and solid-associated fraction of cattle fed two hay qualities differing in sugar content with graded amounts of starchy concentrate feeds using Illumina MiSeq sequencing and quantitative polymerase chain reaction...
September 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28921996/treatments-for-internet-gaming-disorder-and-internet-addiction-a-systematic-review
#2
Kristyn Zajac, Meredith K Ginley, Rocio Chang, Nancy M Petry
Problems related to excessive use of the Internet and video games have recently captured the interests of both researchers and clinicians. The goals of this review are to summarize the literature on treatment effectiveness for these problems and to determine whether any treatments meet the minimum requirement of an evidence-based treatment as defined by Chambless et al. (1998). Studies of treatments for Internet gaming disorder (IGD) and Internet addiction were examined separately, as past studies have linked IGD to more severe outcomes...
September 18, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28919060/sglt2-inhibitors-in-type-1-diabetes-knocked-down-but-up-again
#3
John R Petrie
No abstract text is available yet for this article.
September 13, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28918502/the-refinement-glossary-of-terms-an-international-terminology-for-mental-health-systems-assessment
#4
Ilaria Montagni, Luis Salvador-Carulla, David Mcdaid, Christa Straßmayr, Florian Endel, Petri Näätänen, Jorid Kalseth, Birgitte Kalseth, Tihana Matosevic, Valeria Donisi, Karine Chevreul, Amélie Prigent, Raluca Sfectu, Carmen Pauna, Mencia R Gutiérrez-Colosia, Francesco Amaddeo, Heinz Katschnig
Comparing mental health systems across countries is difficult because of the lack of an agreed upon terminology covering services and related financing issues. Within the European Union project REFINEMENT, international mental health care experts applied an innovative mixed "top-down" and "bottom-up" approach following a multistep design thinking strategy to compile a glossary on mental health systems, using local services as pilots. The final REFINEMENT glossary consisted of 432 terms related to service provision, service utilisation, quality of care and financing...
September 16, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28918240/contingency-management-treatment-in-cocaine-using-methadone-maintained-patients-with-and-without-legal-problems
#5
Meredith K Ginley, Carla J Rash, Todd A Olmstead, Nancy M Petry
BACKGROUND: Legal difficulties and cocaine use are prevalent in methadone maintenance patients, and they are related to one another, as well as to poor response to methadone treatment. Contingency management (CM) is efficacious for decreasing cocaine use, but the relation of CM treatment to criminal activities has rarely been studied. METHODS: This study evaluated whether baseline legal problems are related to subsequent substance use and illegal activities for cocaine using methadone maintained patients and whether CM differentially improves outcomes depending on baseline legal problems...
September 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28915269/the-biometric-antecedents-to-happiness
#6
Petri Böckerman, Alex Bryson, Jutta Viinikainen, Christian Hakulinen, Mirka Hintsanen, Jaakko Pehkonen, Jorma Viikari, Olli Raitakari
It has been suggested that biological markers are associated with human happiness. We contribute to the empirical literature by examining the independent association between various aspects of biometric wellbeing measured in childhood and happiness in adulthood. Using Young Finns Study data (n = 1905) and nationally representative linked data we examine whether eight biomarkers measured in childhood (1980) are associated with happiness in adulthood (2001). Using linked data we account for a very rich set of confounders including age, sex, body size, family background, nutritional intake, physical activity, income, education and labour market experiences...
2017: PloS One
https://www.readbyqxmd.com/read/28910320/differential-gene-expression-following-tlr-stimulation-in-rag1-mutant-zebrafish-tissues-and-morphological-descriptions-of-lymphocyte-like-cell-populations
#7
Preeti J Muire, Larry A Hanson, Robert Wills, Lora Petrie-Hanson
In the absence of lymphocytes, rag1-/- mutant zebrafish develop protective immunity to bacteria. In mammals, induction of protection by innate immunity can be mediated by macrophages or natural killer (NK) cells. To elucidate potential responsive cell populations, we morphologically characterized lymphocyte-like cells (LLCs) from liver, spleen and kidney hematopoietic tissues. In fish, these cells include NK cells and Non-specific cytotoxic cells (NCCs). We also evaluated the transcriptional expression response of select genes that are important indicators of NK and macrophage activation after exposure to specific TLR ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28906241/tracking-of-noise-tolerance-to-measure-hearing-aid-benefit
#8
Francis Kuk, Eric Seper, Chi-Chuen Lau, Petri Korhonen
BACKGROUND: The benefits offered by noise reduction (NR) features on a hearing aid had been studied traditionally using test conditions that set the hearing aids into a stable state of performance. While adequate, this approach does not allow the differentiation of two NR algorithms that differ in their timing characteristics (i.e., activation and stabilization time). PURPOSE: The current study investigated a new method of measuring noise tolerance (Tracking of Noise Tolerance [TNT]) as a means to differentiate hearing aid technologies...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28904393/microrna-pharmacogenomics-based-integrated-model-of-mir-17-92-cluster-in-sorafenib-resistant-hcc-cells-reveals-a-strategy-to-forestall-drug-resistance
#9
Faryal Mehwish Awan, Anam Naz, Ayesha Obaid, Aqsa Ikram, Amjad Ali, Jamil Ahmad, Abdul Khaliq Naveed, Hussnain Ahmed Janjua
Among solid tumors, hepatocellular carcinoma (HCC) emerges as a prototypical therapy-resistant tumor. Considering the emerging sorafenib resistance crisis in HCC, future studies are urgently required to overcome resistance. Recently noncoding RNAs (ncRNAs) have emerged as significant regulators in signalling pathways involved in cancer drug resistance and pharmacologically targeting these ncRNAs might be a novel stratagem to reverse drug resistance. In the current study, using a hybrid Petri net based computational model, we have investigated the harmonious effect of miR-17-92 cluster inhibitors/mimics and circular RNAs on sorafenib resistant HCC cells in order to explore potential resistance mechanisms and to identify putative targets for sorafenib-resistant HCC cells...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899540/moving-into-poverty-during-childhood-is-associated-with-later-sleep-problems
#10
Børge Sivertsen, Tormod Bøe, Jens Christoffer Skogen, Keith J Petrie, Mari Hysing
OBJECTIVE: A social gradient in sleep has been demonstrated across the life span, but previous studies have been cross-sectional and used self-reported socioeconomic status (SES) indicators. Using registry-based data on family income trajectories, the current study examined the association between relative poverty in childhood and subsequent sleep in adolescence. METHODS: Data on family income during 2004-2010 was obtained from the National Income Registry. Poverty was defined as household income <60% of the mean national income...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28895760/application-of-a-semi-automatic-cartilage-segmentation-method-for-biomechanical-modeling-of-the-knee-joint
#11
Mimmi K Liukkonen, Mika E Mononen, Petri Tanska, Simo Saarakkala, Miika T Nieminen, Rami K Korhonen
Manual segmentation of articular cartilage from knee joint 3D magnetic resonance images (MRI) is a time consuming and laborious task. Thus, automatic methods are needed for faster and reproducible segmentations. In the present study, we developed a semi-automatic segmentation method based on radial intensity profiles to generate 3D geometries of knee joint cartilage which were then used in computational biomechanical models of the knee joint. Six healthy volunteers were imaged with a 3T MRI device and their knee cartilages were segmented both manually and semi-automatically...
September 12, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28894974/foxp3-t-cells-are-present-in-kidney-biopsy-samples-in-children-with-tubulointerstitial-nephritis-and-uveitis-syndrome
#12
Sari H Rytkönen, Petri Kulmala, Helena Autio-Harmainen, Pekka Arikoski, Kira Endén, Janne Kataja, Tuomo Karttunen, Matti Nuutinen, Timo Jahnukainen
BACKGROUND: Tubulointerstitial nephritis (TIN) is an inflammatory disease of unknown pathogenesis. To evaluate a possible role of regulatory T cells (Tregs) in the pathophysiology of TIN with (TINU) and without uveitis, we investigated the presence and quantity of FOXP3(+) T regulatory lymphocytes in diagnostic kidney biopsies from pediatric patients. METHODS: A total of 33 patients (14 TIN and 19 TINU) were enrolled. The quantity of CD4(+), FOXP3(+) and double-positive T cells in formalin-fixed kidney biopsies was determined using double label immunohistochemistry with anti-human CD4 and FOXP3 antibodies...
September 11, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28893266/myocardial-performance-index-in-female-athletes
#13
Zahraa Alsafi, Andreas Malmgren, Petri Gudmundsson, Martin Stagmo, Magnus Dencker
BACKGROUND: Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissue Doppler imaging (TDI) in female elite athletes compared to sedentary controls. METHODS: The study consisted of 32 athletes (mean age 20 ± 2 years) and 34 sedentary controls (mean age 23 ± 2 years)...
September 11, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28892895/effectivity-of-titanium-oxide-based-nano-particles-on-e-coli-from-clinical-samples
#14
Hima Bindu Mantravadi
INTRODUCTION: Nanoparticles composed of Titanium Oxide (TiO2) are non toxic, durable, stable and have a high refractive index with a lot of scope in biomedical applications. Due to their antibacterial effects, they can be applied to inanimate objects like glass, metal and even biomedical implants. AIM: This study was conducted to assess the antibacterial effect of Titanium Oxide (TiO2) alone or with Silver (Ag) as an additive on Escherichia coli. MATERIALS AND METHODS: Escherichia coli isolates (n=25) sensitive to most of the drugs including first generation cephalosporins, ampicillin and amoxycillin from various samples like pus, urine, sputum and blood were placed onto the glass slides containing TiO2 annealed at 200°C, 400°C, TiO2 with 0...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28887295/photoaging-mobile-apps-in-school-based-melanoma-prevention-pilot-study
#15
Titus Josef Brinker, Christian Martin Brieske, Christoph Matthias Schaefer, Fabian Buslaff, Martina Gatzka, Maximilian Philip Petri, Wiebke Sondermann, Dirk Schadendorf, Ingo Stoffels, Joachim Klode
BACKGROUND: Around 90% of melanomas are caused by exposure to ultraviolet (UV) radiation and are therefore eminently preventable. Tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to malignant melanoma and other skin cancers are too far in the future to fathom. Given the substantial amount of time children and adolescents spend in schools, as well as with their mobile phones, addressing melanoma prevention via both of these ways is crucial...
September 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28880251/studying-electrotaxis-in-microfluidic-devices
#16
REVIEW
Yung-Shin Sun
Collective cell migration is important in various physiological processes such as morphogenesis, cancer metastasis and cell regeneration. Such migration can be induced and guided by different chemical and physical cues. Electrotaxis, referring to the directional migration of adherent cells under stimulus of electric fields, is believed to be highly involved in the wound-healing process. Electrotactic experiments are conventionally conducted in Petri dishes or cover glasses wherein cells are cultured and electric fields are applied...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28877440/bimodal-grain-size-scaling-of-thermal-transport-in-polycrystalline-graphene-from-large-scale-molecular-dynamics-simulations
#17
Zheyong Fan, Petri Hirvonen, Luiz Felipe C Pereira, Mikko M Ervasti, Ken R Elder, Davide Donadio, Ari Harju, Tapio Ala-Nissila
Grain boundaries in graphene are inherent in wafer-scale samples prepared by chemical vapor deposition. They can strongly influence the mechanical properties and electronic and heat transport in graphene. In this work, we employ extensive molecular dynamics simulations to study thermal transport in large suspended polycrystalline graphene samples. Samples of different controlled grain sizes are prepared by a recently developed efficient multiscale approach based on the phase field crystal model. In contrast to previous works, our results show that the scaling of the thermal conductivity with the grain size implies bimodal behavior with two effective Kapitza lengths...
September 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28877248/flying-foxes-create-extensive-seed-shadows-and-enhance-germination-success-of-pioneer-plant-species-in-deforested-madagascan-landscapes
#18
Ryszard Oleksy, Luca Giuggioli, Thomas J McKetterick, Paul A Racey, Gareth Jones
Seed dispersal plays a significant role in forest regeneration and maintenance. Flying foxes are often posited as effective long-distance seed dispersers due to their large home ranges and ability to disperse seeds when flying. We evaluate the importance of the Madagascan flying fox Pteropus rufus in the maintenance and regeneration of forests in one of the world's priority conservation areas. We tested germination success of over 20,000 seeds from the figs Ficus polita, F. grevei and F. lutea extracted from bat faeces and ripe fruits under progressively more natural conditions, ranging from petri-dishes to outdoor environments...
2017: PloS One
https://www.readbyqxmd.com/read/28877230/decision-impact-and-feasibility-of-different-asco-recommended-biomarkers-in-early-breast-cancer-prospective-comparison-of-molecular-marker-endopredict-and-protein-marker-upa-pai-1
#19
Johannes Ettl, Evelyn Klein, Alexander Hapfelmeier, Kirsten Grosse Lackmann, Stefan Paepke, Christoph Petry, Katja Specht, Laura Wolff, Heinz Höfler, Marion Kiechle
BACKGROUND: Adjuvant therapy decisions in early breast cancer are based on accurate risk assessment. Urokinase plasminogen activator (uPA) and plaminogen activator inhibitor-1 (PAI-1) have been the first biomarkers in hormone receptor (HR) positive breast cancer to reach highest level of evidence. The EndoPredict test (EPclin) combines gene expression information with nodal status and tumor size. The aim of this prospective study was to compare uPA/PAI-1 and EPclin as prognostic biomarkers with regard to feasibility, risk stratification and impact on adjuvant therapy recommendation...
2017: PloS One
https://www.readbyqxmd.com/read/28876340/cisplatin-and-transplatin-interaction-with-methionine-bonding-motifs-assayed-by-vibrational-spectroscopy-in-the-isolated-ionic-complexes
#20
Roberto Paciotti, Davide Corinti, Alberto De Petris, Alessandra Ciavardini, Susanna Piccirillo, Cecilia Coletti, Nazzareno Re, Philippe Maitre, Bruno Bellina, Perdita Barran, Barbara Chiavarino, Maria Elisa Crestoni, Simonetta Fornarini
Cisplatin and transplatin (cis- and trans-[PtCl2(NH3)2]) have been allowed to react with methionine (Met) in water solution in a study aimed to characterize the monofunctional complex primarily formed. The thioether function of methionine is known to have a very high affinity for square planar platinum(ii) and sulfur-containing biomolecules have been proposed as a cisplatin drug reservoir on the way to platination at DNA. Both cisplatin and transplatin yield [PtCl(NH3)2Met](+) complexes, delivered by electrospray ionization in the gas phase and sampled as isolated species using tools based on mass spectrometry...
September 6, 2017: Physical Chemistry Chemical Physics: PCCP
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