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https://www.readbyqxmd.com/read/29774396/tumor-volume-as-a-prognostic-marker-in-p16-positive-and-p16-negative-oropharyngeal-cancer-patients-treated-with-definitive-intensity-modulated-radiotherapy
#1
Timo Carpén, Kauko Saarilahti, Caj Haglund, Antti Markkola, Jussi Tarkkanen, Jaana Hagström, Petri Mattila, Antti Mäkitie
PURPOSE: To investigate the impact of primary gross tumor volume (pGTV) and nodal gross tumor volume (nGTV) in oropharyngeal squamous cell carcinoma (OPSCC) and the difference in their role between human papillomavirus (HPV)-positive and HPV-negative patients. METHODS: The patient cohort consists of 91 OPSCC patients treated with definitive radiochemotherapy or radiotherapy using intensity-modulated radiotherapy (IMRT). All patients had a minimum follow-up of 31 months...
May 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29773134/developmental-capacity-of-ascaridia-galli-eggs-is-preserved-after-anaerobic-storage-in-faeces
#2
B Tarbiat, S Rahimian, D S Jansson, P Halvarsson, J Höglund
The reliability of the results of in vitro studies such as detection of anthelmintic resistance often depends on the ability of the parasite eggs to develop under laboratory conditions. The aim of this study was to assess the embryonation capability of the chicken roundworm Ascaridia galli eggs after storage under different conditions. Two storage media for parasite eggs were used; faeces or water. Eggs in petri dishes (90 dishes in total) containing faces or water media were first exposed either to aerobic or anaerobic conditions at different temperatures (4 °C /+O2 , 4 °C /-O2 , 25 °C/-O2 ) for a maximum of 72 days...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772696/the-effect-of-negative-pressure-wound-therapy-with-and-without-instillation-on-mature-biofilms-in-vitro
#3
Shamaila Tahir, Matthew Malone, Honghua Hu, Anand Deva, Karen Vickery
BACKGROUND: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. METHODS: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w / v equivalent to 1% w / v available iodine, BETADINE® , Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan® , B Braun Medical, Melsungen, Germany), Gentamicin 1 µg/mL (GM) (G1264 Sigma-Aldrich Pty Ltd...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29770474/improving-medication-safety-for-home-nursing-clients-a-prospective-observational-study-of-a-novel-clinical-pharmacy-service-the-visiting-pharmacist-vip-study
#4
C Y Lee, C Beanland, D Goeman, N Petrie, B Petrie, F Vise, J Gray, R A Elliott
WHAT IS KNOWN AND OBJECTIVE: Polypharmacy, medication errors and adverse events are common in older people receiving home nursing medication management support. Access to clinical pharmacists is limited. In Australia, few home nursing clients receive a general practitioner (GP)-initiated pharmacist-led Home Medicines Review, despite their eligibility and community nurses' (CN) efforts to facilitate this. An integrated home nursing clinical pharmacy service, in which CNs directly referred clients to a pharmacist, was therefore developed and piloted...
May 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29767678/identification-of-etiology-specific-diarrhea-associated-with-linear-growth-faltering-in-bangladeshi-infants
#5
Amanda E Schnee, Rashidul Haque, Mami Taniuchi, Jashim Uddin, Masud Alam, Jie Liu, Elizabeth T Rogawski, Beth Kirkpatrick, Eric R Houpt, William A Petri, James A Platts-Mills
Childhood diarrhea in low-resource settings has been variably linked to linear growth shortfalls. However, the association between etiology-specific diarrhea and growth has not been comprehensively evaluated. We tested diarrheal stools collected from the Performance of Rotavirus and Oral Polio Vaccines in Developing Countries study from 2011-2013 in Dhaka, Bangladesh by quantitative polymerase chain reaction for a broad range of enteropathogens to characterize diarrhea etiology and examine the association between etiology-specific diarrhea and linear growth and systemic inflammation...
May 15, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29765616/quantifying-the-burden-of-steroid-related-damage-in-sle-in-the-hopkins-lupus-cohort
#6
Julie E Davidson, Qinggong Fu, Sapna Rao, Laurence S Magder, Michelle Petri
Objective: Corticosteroids are a mainstay of SLE treatment; however, cumulative steroid exposure may lead to organ damage. This study aimed to quantify the risk of new diabetes, hypertension, cataracts, osteoporosis and avascular necrosis that is attributable to cumulative corticosteroid exposure in SLE. Methods: Using data from the Hopkins Lupus Cohort, a longitudinal study of lupus activity, organ damage and quality of life in patients with SLE, five matched case-control analyses nested within a prospectively enrolled SLE cohort were performed...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29762724/aai-profiler-fast-proteome-wide-exploratory-analysis-reveals-taxonomic-identity-misclassification-and-contamination
#7
Alan J Medlar, Petri Törönen, Liisa Holm
We present AAI-profiler, a web server for exploratory analysis and quality control in comparative genomics. AAI-profiler summarizes proteome-wide sequence search results to identify novel species, assess the need for taxonomic reclassification and detect multi-isolate and contaminated samples. AAI-profiler visualises results using a scatterplot that shows the Average Amino-acid Identity (AAI) from the query proteome to all similar species in the sequence database. Taxonomic groups are indicated by colour and marker styles, making outliers easy to spot...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29761716/from-cheese-curls-to-fatty-acid-structure-using-commonplace-analogies-to-teach-science-to-nonmajors
#8
Kathleen Petri Seiler, Jane Huggins
No abstract text is available yet for this article.
June 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29761460/a-primer-for-the-rat-genome-database-rgd
#9
Stanley J F Laulederkind, G Thomas Hayman, Shur-Jen Wang, Jennifer R Smith, Victoria Petri, Matthew J Hoffman, Jeff De Pons, Marek A Tutaj, Omid Ghiasvand, Monika Tutaj, Jyothi Thota, Melinda R Dwinell, Mary Shimoyama
The laboratory rat, Rattus norvegicus, is an important model of human health and disease, and experimental findings in the rat have relevance to human physiology and disease. The Rat Genome Database (RGD, http://rgd.mcw.edu ) is a model organism database that provides access to a wide variety of curated rat data including disease associations, phenotypes, pathways, molecular functions, biological processes and cellular components for genes, quantitative trait loci, and strains. We present an overview of the database followed by specific examples that can be used to gain experience in employing RGD to explore the wealth of functional data available for the rat...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29758452/evaluation-of-machine-learning-algorithms-for-improved-risk-assessment-for-down-s-syndrome
#10
Aki Koivu, Teemu Korpimäki, Petri Kivelä, Tapio Pahikkala, Mikko Sairanen
Prenatal screening generates a great amount of data that is used for predicting risk of various disorders. Prenatal risk assessment is based on multiple clinical variables and overall performance is defined by how well the risk algorithm is optimized for the population in question. This article evaluates machine learning algorithms to improve performance of first trimester screening of Down syndrome. Machine learning algorithms pose an adaptive alternative to develop better risk assessment models using the existing clinical variables...
May 4, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29756867/strong-neutron-pairing-in-core-4n-nuclei
#11
A Revel, F M Marqués, O Sorlin, T Aumann, C Caesar, M Holl, V Panin, M Vandebrouck, F Wamers, H Alvarez-Pol, L Atar, V Avdeichikov, S Beceiro-Novo, D Bemmerer, J Benlliure, C A Bertulani, J M Boillos, K Boretzky, M J G Borge, M Caamaño, E Casarejos, W N Catford, J Cederkäll, M Chartier, L Chulkov, D Cortina-Gil, E Cravo, R Crespo, U Datta Pramanik, P Díaz Fernández, I Dillmann, Z Elekes, J Enders, O Ershova, A Estradé, F Farinon, L M Fraile, M Freer, D Galaviz, H Geissel, R Gernhäuser, P Golubev, K Göbel, J Hagdahl, T Heftrich, M Heil, M Heine, A Heinz, A Henriques, A Ignatov, H T Johansson, B Jonson, J Kahlbow, N Kalantar-Nayestanaki, R Kanungo, A Kelic-Heil, A Knyazev, T Kröll, N Kurz, M Labiche, C Langer, T Le Bleis, R Lemmon, S Lindberg, J Machado, J Marganiec, A Movsesyan, E Nacher, M Najafi, T Nilsson, C Nociforo, S Paschalis, A Perea, M Petri, S Pietri, R Plag, R Reifarth, G Ribeiro, C Rigollet, M Röder, D Rossi, D Savran, H Scheit, H Simon, I Syndikus, J T Taylor, O Tengblad, R Thies, Y Togano, P Velho, V Volkov, A Wagner, H Weick, C Wheldon, G Wilson, J S Winfield, P Woods, D Yakorev, M Zhukov, A Zilges, K Zuber
The emission of neutron pairs from the neutron-rich N=12 isotones ^{18}C and ^{20}O has been studied by high-energy nucleon knockout from ^{19}N and ^{21}O secondary beams, populating unbound states of the two isotones up to 15 MeV above their two-neutron emission thresholds. The analysis of triple fragment-n-n correlations shows that the decay ^{19}N(-1p)^{18}C^{*}→^{16}C+n+n is clearly dominated by direct pair emission. The two-neutron correlation strength, the largest ever observed, suggests the predominance of a ^{14}C core surrounded by four valence neutrons arranged in strongly correlated pairs...
April 13, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756076/gap-junctional-communication-is-involved-in-differentiation-of-osteoclasts-from-bone-marrow-and-peripheral-blood-monocytes
#12
Elina Kylmäoja, Miho Nakamura, Hanna Kokkonen-Puuperä, Veli-Pekka Ronkainen, Petri Lehenkari, Juha Tuukkanen
Aims: The aim of the study was to compare the influence of gap junctional communication (GJC) in osteoclastogenesis from bone marrow (BM) and peripheral blood (PB) monocytes. These widely used sources differ in purity, since BM cultures contain a significant number of stromal cells. We studied whether stimulation of GJC in BM monocyte/stromal cell cultures differs from the effect in pure PB monocyte cultures. We compared the differentiation also in acidosis, which is a known inducer of bone resorption...
May 2018: Heliyon
https://www.readbyqxmd.com/read/29755205/enumerating-viable-phytoplankton-using-a-culture-based-most-probable-number-assay-following-ultraviolet-c-treatment
#13
Hugh L MacIntyre, John J Cullen, Trina J Whitsitt, Brian Petri
Ballast water management systems (BWMS) must be tested to assess their compliance with standards for the discharge of organisms, for example in the ≥ 10- and < 50-μm size category, which is dominated by phytoplankton. Assessment of BWMS performance with the vital stains fluorescein diacetate + 5-chlorofluorescein diacetate, required by regulations in the USA, is problematic in the case of ultraviolet-C (UVC) radiation. This is because UVC targets nucleotides-and thus reproduction, hence viability-rather than membrane integrity, which is assayed by the stains...
2018: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29754390/the-importance-of-contextual-relational-and-cognitive-factors-for-novice-nurses-emotional-state-and-affective-commitment-to-the-profession-a-multilevel-study
#14
Yvonne Ten Hoeve, Jasperina Brouwer, Petrie F Roodbol, Saskia Kunnen
AIM: This study explored the effects of contextual, relational and cognitive factors derived from novice nurses' work experiences on emotions and affective commitment to the profession. BACKGROUND: With an increasing demand for well-trained nurses, it is imperative to investigate which work-related factors most affect their commitment to develop effective strategies to improve work conditions, work satisfaction and emotional attachment. DESIGN: A repeated-measures within subjects design...
May 13, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29751365/the-interplay-between-risk-and-preventive-factors-explains-why-some-children-develop-allergies-to-certain-foods-and-others-show-tolerance
#15
REVIEW
Sami Remes, Petri Kulmala
AIM: A number of studies have clarified the tolerance mechanisms and risk factors for food allergies. Our aim was to explore food allergy symptoms by target organs, together with the risk factors and how to prevent food allergies and induce tolerance. METHODS: We carried out a thorough review of studies on paediatric food allergies published in the last decade. RESULTS: Food allergy symptoms may affect the skin, nasal and oral mucosa, conjunctivae, gastrointestinal tract, or, in severe cases, the respiratory tract and cardiovascular organs...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29751209/differential-involvement-of-forearm-muscles-in-als-does-not-relate-to-sonographic-structural-nerve-alterations
#16
Stefanie Schreiber, Frank Schreiber, Grazyna Debska-Vielhaber, Cornelia Garz, Nathalie Hensiek, Judith Machts, Susanne Abdulla, Reinhard Dengler, Susanne Petri, Peter J Nestor, Stefan Vielhaber
OBJECTIVE: We aimed to assess whether differential peripheral nerve involvement parallels dissociated forearm muscle weakness in amyotrophic lateral sclerosis (ALS). METHODS: The analysis comprised 41 ALS patients and 18 age-, sex-, height- and weight-matched healthy controls. Strength of finger-extension and -flexion was measured using the Medical Research Council (MRC) scale. Radial, median and ulnar nerve sonographic cross-sectional area (CSA) and echogenicity, expressed by the hypoechoic fraction (HF), were determined...
May 1, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29750150/-in-vitro-lethal-activity-of-the-nematophagous-fungus-clonostachys-rosea-ascomycota-hypocreales-against-nematodes-of-five-different-taxa
#17
Rosalia Rodríguez-Martínez, Pedro Mendoza-de-Gives, Liliana Aguilar-Marcelino, María Eugenia López-Arellano, Marcela Gamboa-Angulo, Greta Hanako Rosas-Saito, Manuela Reyes-Estébanez, Virginia Guadalupe García-Rubio
This study was aimed to evaluate the in vitro lethal activity of the nematophagous fungi Clonostachys rosea against 5 nematodes species belonging to different taxa. Two groups of 35 Petri dishes (PD) each were divided into 5 series of 7 (PD). Group 1 (series 1, 2, 3, 4, and 5) contained only water agar; meanwhile group 2 plates (series 6, 7, 8, 9, and 10) contained C. rosea cultures growth on water agar. Every plate from the two groups was added with 500 nematodes corresponding to the following genera/specie: Haemonchus contortus , Caenorhabditis elegans, Rhabditis sp...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29748996/exposure-response-analysis-for-evaluation-of-semaglutide-dose-levels-in-type-2-diabetes
#18
Kristin C C Petri, Steen H Ingwersen, Anne Flint, Jeppe Zacho, Rune V Overgaard
AIMS: Semaglutide is a glucagon-like peptide-1 analogue approved for the treatment of type 2 diabetes. To evaluate dose levels, we examined the effects of demographic factors on efficacy and safety in an exposure-response analysis. METHODS: We analysed data from 1552 adults from four randomised phase 3 trials of 30-56 weeks' duration investigating once-weekly semaglutide doses 0.5 and 1.0 mg. Exposure-response relationships were investigated using graphical and model-based techniques to assess the two dose levels and subgroups with the highest and lowest exposure and response...
May 11, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29748788/biological-response-of-an-in-vitro-human-3d-lung-cell-model-exposed-to-brake-wear-debris-varies-based-on-brake-pad-formulation
#19
Hana Barosova, Savvina Chortarea, Pavlina Peikertova, Martin J D Clift, Alke Petri-Fink, Jana Kukutschova, Barbara Rothen-Rutishauser
Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic automotive brake pads used in mid-size passenger cars by a full-scale brake dynamometer with an environmental chamber simulating urban driving and to deduce their potential hazard in vitro...
May 10, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29748031/multimorbidity-is-associated-with-uptake-of-influenza-vaccination
#20
Samantha M Harrison, Melissa Y Wei, Lois E Lamerato, Joshua G Petrie, Emily Toth Martin
OBJECTIVE: Patients with chronic conditions have higher rates of severe influenza-related illness and mortality. However, influenza vaccination coverage in high-risk populations continues to be suboptimal. We describe the association between cumulative disease morbidity, measured by a previously validated multimorbidity index, and influenza vaccination among community-dwelling adults. METHODS: We obtained interview and medical record data for participants  ≥18 years who sought outpatient care for influenza-like illness between 2011 and 2016 as part of an outpatient-based study of influenza vaccine effectiveness...
May 7, 2018: Vaccine
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