Shuanzhi Wu, Tenghua Wang, Jieyun Li, Zhixin Zhang, Chen Li, Shuangshuang Xiao, Jin He, Xuan Wang, Zhiqin Hu, Xiaole Wang, Sichao Zheng, Xintong Liang, Guiying Chen, Yongmei Li, Xianbo Li, Yaoxuan Zhan, Qinwen Zou, Hongliang Jiang, Qingshan Zheng, Li Ban, Haiyan Liu, Yi Fang
BACKGROUND: SAR107375E is a direct dual inhibitor of both Factor Xa and Factor IIa and has shown potent anticoagulation activity in vitro and animals. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending intravenous doses of SAR107375E in healthy Chinese adult subjects. METHODS: In this randomized, double-blind, placebo-controlled trial, 60 healthy Chinese adult subjects were administered intravenously single ascending doses (0...
November 13, 2023: Expert Opinion on Investigational Drugs