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White matter hyperintensities

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https://www.readbyqxmd.com/read/28324763/interaction-of-apoe-e4-and-poor-glycemic-control-predicts-white-matter-hyperintensity-growth-from-73-to-76
#1
Simon R Cox, Stuart J Ritchie, David Alexander Dickie, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Sarah E Harris, Maria Valdés Hernández, Alan J Gow, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio...
February 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28324197/the-spectrum-of-magnetic-resonance-findings-in-cerebrotendinous-xanthomatosis-redefinition-and-evidence-of-new-markers-of-disease-progression
#2
Andrea Mignarri, Maria Teresa Dotti, Antonio Federico, Nicola De Stefano, Marco Battaglini, Irene Grazzini, Paolo Galluzzi, Lucia Monti
Cerebrotendinous xanthomatosis (CTX) is a metabolic disease characterized by systemic signs and neurological impairment, which can be prevented if chenodeoxycholic acid (CDCA) treatment is started early. Despite brain MRI represents an essential diagnostic tool, the spectrum of findings is worth to be reappraised, and follow-up data are needed. We performed clinical evaluation and brain MRI in 38 CTX patients. Sixteen of them who were untreated at baseline examination underwent clinical and MRI follow-up after long-term treatment with CDCA...
March 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28323582/white-matter-integrity-in-high-altitude-pilots-exposed-to-hypobaria
#3
Stephen A McGuire, Goldie R E Boone, Paul M Sherman, David F Tate, Joe D Wood, Beenish Patel, George Eskandar, S Andrea Wijtenburg, Laura M Rowland, Geoffrey D Clarke, Patrick M Grogan, John H Sladky, Peter V Kochunov
INTRODUCTION: Nonhypoxic hypobaric (low atmospheric pressure) occupational exposure, such as experienced by U.S. Air Force U-2 pilots and safety personnel operating inside altitude chambers, is associated with increased subcortical white matter hyperintensity (WMH) burden. The pathophysiological mechanisms underlying this discrete WMH change remain unknown. The objectives of this study were to demonstrate that occupational exposure to nonhypoxic hypobaria is associated with altered white matter integrity as quantified by fractional anisotropy (FA) measured using diffusion tensor imaging and relate these findings to WMH burden and neurocognitive ability...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28320161/circulating-autoantibodies-against-the-nr2-peptide-of-the-nmda-receptor-are-associated-with-subclinical-brain-damage-in-hypertensive-patients-with-other-pre-existing-conditions-for-vascular-risk
#4
S González-García, A González-Quevedo, Z Hernandez-Diaz, L Alvarez Camino, M Peña-Sanchez, A Cordero-Eiriz, M Brown, J A Gaya, M Betancourt-Losa, I Fernandez-Almirall, M C Menendez-Sainz, R Fernandez-Carriera
Arterial hypertension (HT) and other vascular pre-existing conditions (PEC) generate asymptomatic brain damage which increases the occurrence of stroke and cognitive decline. The aim of this work was to explore if serum antibodies against the NR2 subunit of the NMDA receptor (NR2Ab) could predict subclinical brain damage (SBD) in hypertensive patients with PEC. Forty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319156/differential-impact-of-serum-total-bilirubin-level-on-cerebral-atherosclerosis-and-cerebral-small-vessel-disease
#5
Jonguk Kim, Seung-Jae Yoon, Min-Hee Woo, Sang-Heum Kim, Nam-Keun Kim, Jinkwon Kim, Ok-Joon Kim, Seung-Hun Oh
BACKGROUND: A low serum total bilirubin (T-bil) level is associated with an increased risk of atherosclerosis. However, the differential impact of the serum T-bil level on cerebral atherosclerosis and cerebral small vessel disease (SVD) is still unclear. METHODS: We evaluated serum T-bil levels from 1,128 neurologically healthy subjects. Indices of cerebral atherosclerosis (extracranial arterial stenosis [ECAS] and intracranial arterial stenosis [ICAS]), and indices of SVD (silent lacunar infarct [SLI], and moderate-to-severe white matter hyperintensities [msWMH]) were evaluated by the use of brain magnetic resonance imaging (MRI) and MR angiography...
2017: PloS One
https://www.readbyqxmd.com/read/28318355/dementia-incidence-and-predictors-in-cerebral-amyloid-angiopathy-patients-without-intracerebral-hemorrhage
#6
Li Xiong, Gregoire Boulouis, Andreas Charidimou, Duangnapa Roongpiboonsopit, Michael J Jessel, Marco Pasi, Yael D Reijmer, Panagiotis Fotiadis, Alison Ayres, Emily Merrill, Kristin Schwab, Deborah Blacker, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
Cerebral amyloid angiopathy (CAA) is a common cause of cognitive impairment in older individuals. This study aimed to investigate predictors of dementia in CAA patients without intracerebral hemorrhage (ICH). A total of 158 non-demented patients from the Stroke Service or the Memory Clinic who met the modified Boston Criteria for probable CAA were included. At baseline, neuroimaging markers, including lobar microbleeds (cerebral microbleeds (CMBs)), white matter hyperintensities (WMH), cortical superficial siderosis (cSS), magnetic resonance imaging (MRI)-visible centrum semiovale perivascular spaces (CSO-PVS), lacunes, and medial temporal atrophy (MTA) were assessed...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28316994/multiple-factors-involved-in-the-pathogenesis-of-white-matter-lesions
#7
REVIEW
Jing Lin, Dilong Wang, Linfang Lan, Yuhua Fan
White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28315460/classification-and-characterization-of-periventricular-and-deep-white-matter-hyperintensities-on-mri-a-study-in-older-adults
#8
REVIEW
Ludovica Griffanti, Mark Jenkinson, Sana Suri, X X, Abda Mahmood, Nicola Filippini, Claire E Sexton, Anya Topiwala, Charlotte Allan, Mika Kivimäki, Archana Singh-Manoux, Klaus P Ebmeier, Clare E Mackay, Giovanna Zamboni
White matter hyperintensities (WMH) are frequently divided into periventricular (PWMH) and deep (DWMH), and the two classes have been associated with different cognitive, microstructural, and clinical correlates. However, although this distinction is widely used in visual ratings scales, how to best anatomically define the two classes is still disputed. In fact, the methods used to define PWMH and DWMH vary significantly between studies, making results difficult to compare. The purpose of this study was twofold: first, to compare four current criteria used to define PWMH and DWMH in a cohort of healthy older adults (mean age: 69...
March 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28298048/carotid-atherosclerotic-plaque-instability-and-cognition-determined-by-ultrasound-measured-plaque-strain-in-asymptomatic-patients-with-significant-stenosis
#9
Robert J Dempsey, Tomy Varghese, Daren C Jackson, Xiao Wang, Nirvedh H Meshram, Carol C Mitchell, Bruce P Hermann, Sterling C Johnson, Sara E Berman, Stephanie M Wilbrand
OBJECTIVE This article describes the use of ultrasound measurements of physical strain within carotid atherosclerotic plaques as a measure of instability and the potential for vascular cognitive decline, microemboli, and white matter changes. METHODS Asymptomatic patients with significant (> 60%) carotid artery stenosis were studied for dynamic measures of plaque instability, presence of microemboli, white matter changes, and vascular cognitive decline in comparison with normative controls and premorbid state...
March 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28291429/pathophysiological-consideration-of-medullary-streaks-on-flair-imaging-in-pediatric-moyamoya-disease
#10
Hime Suzuki, Takeshi Mikami, Tomoyoshi Kuribara, Kazuhisa Yoshifuji, Katsuya Komatsu, Yukinori Akiyama, Hirofumi Ohnishi, Kiyohiro Houkin, Nobuhiro Mikuni
OBJECTIVE Medullary streaks detected on fluid-attenuated inversion recovery (FLAIR) imaging have been considered to be reflected ischemic regions in pediatric moyamoya disease. The purpose of this study was to evaluate these medullary streaks both clinically and radiologically and to discuss associated pathophysiological concerns. METHODS The authors retrospectively reviewed data from 14 consecutive pediatric patients with moyamoya disease treated between April 2009 and June 2016. Clinical and radiological features and postoperative imaging changes were analyzed...
March 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28290939/susceptibility-weighted-imaging-and-white-matter-abnormality-findings-in-service-members-with-persistent-cognitive-symptoms-following-mild-traumatic-brain-injury
#11
David F Tate, Maria Gusman, Jonathan Kini, Matthew Reid, Carmen S Velez, Ann Marie Drennon, Douglas B Cooper, Jan E Kennedy, Amy O Bowles, Erin D Bigler, Jeffrey D Lewis, John Ritter, Gerald E York
Mild traumatic brain injury (mTBI) is a major health concern among active duty service members and Veterans returning from combat operations, and it can result in variable clinical and cognitive outcomes. Identifying biomarkers that can improve diagnosis and prognostication has been at the forefront of recent research efforts. The purpose of this study was to compare the sensitivity and specificity of abnormalities identified using more traditional magnetic resonance imaging (MRI) sequences such as fluid attenuation inversion recovery (FLAIR) to more advanced MRI sequences such as susceptibility weighted imaging (SWI) among a cohort of active duty service members experiencing persistent cognitive symptoms after mTBI...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28289478/cerebral-white-matter-hyperintensities-on-mri-and-acceleration-of-epigenetic-aging-the-atherosclerosis-risk-in-communities-study
#12
Abhay Raina, Xiaoping Zhao, Megan L Grove, Jan Bressler, Rebecca F Gottesman, Weihua Guan, James S Pankow, Eric Boerwinkle, Thomas H Mosley, Myriam Fornage
BACKGROUND: Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and dementia. We investigated the association of cerebral WMH burden on MRI with a DNA methylation-based biomarker of aging, termed DNA methylation age acceleration, which represents the deviation of the DNA methylation-predicted age from the chronologic age. RESULTS: In this cross-sectional observational study of 713 African-American participants of the Atherosclerosis Risk in Communities study, aged 51-73 years, estimates of predicted age were obtained based on two algorithms (Hannum et al...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28285092/visceral-to-subcutaneous-fat-ratio-is-independently-related-to-small-and-large-cerebrovascular-lesions-even-in-healthy-subjects
#13
Satoshi Higuchi, Yusuke Kabeya, Kiyoe Kato
BACKGROUND AND AIMS: The severity of obesity is evaluated by visceral-to-subcutaneous fat ratio (VS ratio), which may be useful for predicting atherosclerosis. However, it is unclear how VS ratio affects different types of cerebrovascular lesions. This study was conducted to evaluate the clinical impact of visceral fat accumulation on the cerebrovascular lesions. METHODS: This cross-sectional study included 980 apparently healthy Japanese adults who underwent a health check-up program focused toward atherosclerosis, between 2011 and 2014...
March 2, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28282807/radiological-pathological-correlation-in-alzheimer-s-disease-systematic-review-of-antemortem-magnetic-resonance-imaging-findings
#14
Caroline Dallaire-Théroux, Brandy L Callahan, Olivier Potvin, Stephan Saikali, Simon Duchesne
BACKGROUND: The standard method of ascertaining Alzheimer's disease (AD) remains postmortem assessment of amyloid plaques and neurofibrillary degeneration. Vascular pathology, Lewy bodies, TDP-43, and hippocampal sclerosis are frequent comorbidities. There is therefore a need for biomarkers that can assess these etiologies and provide a diagnosis in vivo. OBJECTIVE: We conducted a systematic review of published radiological-pathological correlation studies to determine the relationship between antemortem magnetic resonance imaging (MRI) and neuropathological findings in AD...
March 6, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28282640/longitudinal-segmentation-of-age-related-white-matter-hyperintensities
#15
Carole H Sudre, M Jorge Cardoso, Sebastien Ourselin
Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns...
February 24, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28279605/memory-alterations-and-white-matter-hyperintensities-in-elderly-patients-with-hypertension-the-adelahyde-2-study
#16
João Pedro Ferreira, Anna Kearney Schwartz, Ghassan Watfa, Lamiral Zohra, Jacques Felblinger, Jean-Marc Boivin, Serge Bracard, Gabriella Hossu, Antoine Verger, Laure Joly, Faiez Zannad, Patrick Rossignol, Athanase Benetos
OBJECTIVES: The longitudinal ADELAHYDE-2 study aims to identify the factors associated with cognitive impairment/decline and white matter hyperintensities burden. METHODS: Longitudinal single-center study comprising two visits separated by approximately 7 years. A total of 131 patients completed the two visits. The primary outcome was global memory composite scale, while the secondary outcome was white matter hyperintensities (WMH/Fazekas scale) load. RESULTS: Global memory at visit 2 (V2) was largely influenced by age, smoking status, glycated hemoglobin, and history of stroke already present at visit 1 (V1)...
March 6, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28276131/different-clinical-effect-of-four-antidementia-drugs-for-alzheimer-s-disease-patients-depending-on-white-matter-severity
#17
Yusuke Fukui, Nozomi Hishikawa, Jin Ichinose, Kota Sato, Yumiko Nakano, Ryuta Morihara, Yasuyuki Ohta, Toru Yamashita, Koji Abe
AIM: To examine the clinical effect of four antidementia drugs (donepezil, galantamine, rivastigmine and memantine) in Alzheimer's disease patients who were divided into subgroups based on their periventricular hyperintensity (PVH) severity. METHODS: A total of 551 Alzheimer's disease patients (201 men and 350 women) were divided into four subgroups based on their PVH severity (0-III). They received monotherapy for 12 months. We compared the clinical effects at the baseline, and at 3, 6 and 12 months after initiation...
March 9, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28275700/peripheral-inflammatory-markers-indicate-microstructural-damage-within-periventricular-white-matter-hyperintensities-in%C3%A2-alzheimer-s-disease-a-preliminary-report
#18
Walter Swardfager, Di Yu, Joel Ramirez, Hugo Cogo-Moreira, Gregory Szilagyi, Melissa F Holmes, Christopher J M Scott, Gustavo Scola, Pak C Chan, Jialun Chen, Parco Chan, Demetrios J Sahlas, Nathan Herrmann, Krista L Lanctôt, Ana C Andreazza, Jacqueline A Pettersen, Sandra E Black
INTRODUCTION: White matter hyperintensities (WMH) presumed to reflect cerebral small vessel disease and increased peripheral inflammatory markers are found commonly in Alzheimer's disease (AD), but their interrelationships remain unclear. METHODS: Inflammatory markers were assayed in 54 elderly participants (n = 16 with AD). Periventricular WMH were delineated from T1, T2/proton density, and fluid-attenuated magnetic resonance imaging using semiautomated fuzzy lesion extraction and coregistered with maps of fractional anisotropy (FA), a measure of microstructural integrity assessed using diffusion tensor imaging...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28271327/hypoxia-and-inflammation-indicate-significant-differences-in-the-severity-of-obstructive-sleep-apnea-within-similar-apnea-hypopnea-index-groups
#19
Aynur Yilmaz Avci, Suat Avci, Huseyin Lakadamyali, Ufuk Can
PURPOSE: We determined whether hypoxia parameters are associated with C-reactive protein (CRP), mean platelet volume (MPV), white matter hyperintensity (WMH), and the severity of obstructive sleep apnea (OSA), and also evaluated whether hypoxia parameters, CRP, MPV, and WMH differ in patients with similar apnea-hypopnea index (AHI) scores. METHODS: A total of 297 patients, who were evaluated using polysomnography, were assessed retrospectively. The measured hypoxia parameters included total sleep time with oxygen saturation <90% (ST90), percentage of cumulative time with oxygen saturation <90% (CT90), and lowest oxygen saturation (min SaO2)...
March 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28268289/a-challenging-issue-detection-of-white-matter-hyperintensities-in-neonatal-brain-mri
#20
Baptiste Morel, Yongchao Xu, Alessio Virzi, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch
The progress of magnetic resonance imaging (MRI) allows for a precise exploration of the brain of premature infants at term equivalent age. The so-called DEHSI (diffuse excessive high signal intensity) of the white matter of premature brains remains a challenging issue in terms of definition, and thus of interpretation. We propose a semi-automatic detection and quantification method of white matter hyperintensities in MRI relying on morphological operators and max-tree representations, which constitutes a powerful tool to help radiologists to improve their interpretation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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