Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Lisa C Silbert, Natalie E Roese, Victoria Krajbich, Justin Hurworth, David Lahna, Daniel L Schwartz, Hiroko H Dodge, Randall L Woltjer
INTRODUCTION: Age-related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH and surrounding normal appearing white matter (NAWM), with a focus on astroglial phenotypes. METHODS: Brain samples from 51 oldest old Oregon Alzheimer's Disease Research Center participants who came to autopsy underwent post mortem (PM) 7 tesla MRI with targeted histopathological sampling of WMHs and NAWM...
April 17, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#2
Ghadah Alnosair, Khalid A Alanazi, Fatima I Alhumaid, Bayan S Alshuhayb
Multiple sclerosis (MS) is the most common demyelinating disease affecting the central nervous system. It has a wide range of manifestations and commonly affects the visual system. Many patients with MS report decreased vision, diplopia, nystagmus, and abnormal ocular motility. Nevertheless, bilateral horizontal gaze palsies are exceptionally rarely seen. We present the case of a 24-year-old female who came to our pediatric ophthalmology clinic complaining of bilateral horizontal gaze palsy, photophobia, and eye pain for 2 days...
2024: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
#3
JOURNAL ARTICLE
Hao Li, Mina A Jacob, Mengfei Cai, Roy P C Kessels, David G Norris, Marco Duering, Frank-Erik De Leeuw, Anil Man Tuladhar
BACKGROUND AND OBJECTIVES: Previous studies have linked the MRI measures of perivascular spaces (PVSs), diffusivity along the perivascular spaces (DTI-ALPS), and free water (FW) to cerebral small vessel disease (SVD) and SVD-related cognitive impairments. However, studies on the longitudinal associations between the three MRI measures, SVD progression, and cognitive decline are lacking. This study aimed to explore how PVS, DTI-ALPS, and FW contribute to SVD progression and cognitive decline...
May 2024: Neurology
#4
JOURNAL ARTICLE
Zenghui Fu, Yan Jin, Zaihong Lin, Yan Jiang, Shu DU, Jing Liu, Guangping Zhang, Yang Liu, Huili Yu
OBJECTIVES: Migraine and tremor share some genetic mutation sites, and clinical studies have also confirmed their correlation. This study aims to explore the clinical and electrophysiological characteristics of migraine patients with concomitant tremor, and to analyze the relevant influential factors of tremor occurrence. METHODS: We retrospectively analyzed the clinical data of 217 migraine patients who visited the Third Affiliated Hospital of Qiqihar Medical University from June 2022 to October 2023...
January 28, 2024: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
#5
JOURNAL ARTICLE
Mohamad Gamal Nada, Yassir Edrees Almalki, Mohammad Abd Alkhalik Basha, Maha Ibrahim Metwally, Riham Dessouky, Mohamed Hesham Saleh Saleh Radwan, Mohamed M A Zaitoun, Ahmed A El-Hamid M Abdalla, Ahmed A A Bessar, Engy Fathy Tantwy, Mostafa Mohamad Assy, Bassant Mahmoud Dawoud, Diana Hanna, Mahmoud M Gohary, Sharifa Khalid Alduraibi, Alaa K Lduraibi, Diaa Bakry Eldib, Hamada M Khater, Noha T Sarhan, Dina Esmat Hamed, Sara F Saadawy, Mohammed A Huneif, Ahmed M Abdelkhalik Basha, Yasmin Ibrahim Libda
RATIONALE AND OBJECTIVES: Neurological complications associated with coronavirus disease (COVID-19) have been reported in children; however, data on neuroimaging findings remain limited. This study aimed to comprehensively examine neuroimaging patterns of COVID-19 in children and their relationship with clinical outcomes. MATERIALS AND METHODS: This retrospective cross-sectional study involved reviewing the medical records and MRI scans of 95 children who developed new neurological symptoms within 2-4 weeks of clinical and laboratory confirmation of COVID-19...
April 12, 2024: Academic Radiology
#6
JOURNAL ARTICLE
Juan Du, Changhua Qu, Ziwei Xu, Zhengxin Liu, Mingxuan Lv, Dan Wang, Wenshi Wei, Yu Duan, Jun Shen
OBJECTIVES: The relationship between cognitive function and frailty in moyamoya disease (MMD) remains unclear, and the underlying mechanism is poorly understood. This study aims to investigate whether white matter hyperintensities (WMHs) mediate the association between frailty and cognitive impairment in MMD. METHODS: Patients with MMD were consecutively enrolled in our study from January 2021 to May 2023. Pre-admission frailty and cognition were assessed using the Clinical Frailty Scale (CFS) and cognitive tests, respectively...
April 9, 2024: Clinical Neurology and Neurosurgery
#7
JOURNAL ARTICLE
Joyce R Chong, Yuek Ling Chai, Amelia T Y Yam, Saima Hilal, Henri Vrooman, Narayanaswamy Venketasubramanian, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Christopher P Chen, Mitchell K P Lai
INTRODUCTION: While elevated blood glial fibrillary acidic protein (GFAP) has been associated with brain amyloid pathology, whether this association occurs in populations with high cerebral small vessel disease (CSVD) concomitance remains unclear. METHODS: Using a Singapore-based cohort of cognitively impaired subjects, we assessed associations between plasma GFAP and neuroimaging measures of brain amyloid and CSVD, including white matter hyperintensities (WMH)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#8
JOURNAL ARTICLE
Chin Hong Tan, Jacinth J X Tan
BACKGROUND: White matter hyperintensities (WMHs) represent diffuse small vessel disease implicating the cardiac, systemic, and cerebral vasculatures. As the brain may be the end-organ of cumulative vascular disease, and higher education is protective of both cardiovascular and brain health, we aim to clarify their intertwining relationships. METHODS: We evaluated participants (mean age = 64) from the UK Biobank with neuroimaging measures of WMHs, left ventricular ejection fraction (LVEF) quantified using cardiovascular MRI, and arterial stiffness index (ASI) quantified using finger photoplethysmography...
April 9, 2024: International Journal of Cardiology
#9
JOURNAL ARTICLE
Ruixue Zhou, Qingqing Cai, Chen Liu, Jingni Hui, Meijuan Kang, Yifan Gou, Ye Liu, Panxing Shi, Bingyi Wang, Feng Zhang
Although previous studies have explored the associations of white matter hyperintensity with psychiatric disorders, the sample size is small and the conclusions are inconsistent. The present study aimed to further systematically explore the association in a larger sample. All data were extracted from the UK Biobank. First, general linear regression models and logistic regression models were used to assess the association between white matter hyperintensity volume and anxiety/depression. White matter hyperintensity has been classified into periventricular white matter hyperintensity and deep white matter hyperintensity...
April 1, 2024: Cerebral Cortex
#10
JOURNAL ARTICLE
Shiraz Vered, Sharon Sznitman, Galit Weinstein
BACKGROUND: Cannabis use has increased in recent years. However, the long-term implications of cannabis use on brain health remain unknown. We explored the associations of cannabis use with volumetric brain magnetic resonance imaging (MRI) measures in dementia-free older adults. METHODS: This cross-sectional and longitudinal study included dementia-free participants of the UK Biobank aged ≥60 years. Linear regression models were used to evaluate the association of cannabis use and patterns of use with volumetric brain MRI measures...
April 1, 2024: Age and Ageing
#11
JOURNAL ARTICLE
Muhammad Febrian Rachmadi, Michal Byra, Henrik Skibbe
In this study, we introduce "instance loss functions", a new family of loss functions designed to enhance the training of neural networks in the instance-level segmentation and detection of objects in biomedical image data, particularly those of varied numbers and sizes. Intended to be utilized conjointly with traditional loss functions, these proposed functions, prioritize object instances over pixel-by-pixel comparisons. The specific functions, the instance segmentation loss (Linstance ), the instance center loss (Lcenter ), the false instance rate loss (Lfalse ), and the instance proximity loss (Lproximity ), serve distinct purposes...
April 8, 2024: Computers in Biology and Medicine
#12
JOURNAL ARTICLE
Zhang Zhi, Xiao Liang, Muhua Huang, Lin Wu, Fuqing Zhou
The objective of this study is to explore the relationship between the glymphatic system and alterations in the structure and function of the brain in white matter hyperintensity (WMH) patients. MRI data were collected from 27 WMH patients and 23 healthy controls. We calculated the along perivascular space (ALPS) indices, the anterior corner distance of the lateral ventricle, and the width of the third ventricle for each subject. The DPABISurf tool was used to calculate the cortical thickness and cortical area...
May 8, 2024: Neuroreport
#13
JOURNAL ARTICLE
Abigail Dove, Jie Guo, Jiao Wang, Davide Liborio Vetrano, Sakura Sakakibara, Erika J Laukka, David A Bennett, Weili Xu
INTRODUCTION: The presence of multiple cardiometabolic diseases (CMDs) has been linked to increased dementia risk, but the combined influence of CMDs on cognition and brain structure across the life course is unclear. METHODS: In the UK Biobank, 46,562 dementia-free participants completed a cognitive test battery at baseline and a follow-up visit 9 years later, at which point 39,306 also underwent brain magnetic resonance imaging. CMDs (diabetes, heart disease, and stroke) were ascertained from medical records...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#14
Zulaikha Abdul Rahman, Shahidatul-Adha Mohamad, Hanisah Abdul Hamid
This is a report on remarkable visual recovery from blindness in a case of isolated optic perineuritis (OPN). A 68-year-old Chinese lady presented with a two-week history of progressive painless bilateral vision loss. Her vision was 6/18 on the right eye and no perception of light (NPL) on the left eye with positive relative afferent pupillary defect (RAPD). Fundus showed hyperaemic and swollen optic disc bilaterally. MRI of the brain and orbit revealed hyperintense periventricular white matter lesions, possibly early changes of multiple sclerosis (MS), and perineural enhancement of optic nerve bilaterally, consistent with OPN...
March 2024: Curēus
#15
Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca, Ewoud van der Lelij, Frederik Barkhof, Thomas Benke, Christopher P L H Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G Exalto, Evan F Fletcher, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L Koek, Andrea B Maier, Pauline M Maillard, Cheryl R McCreary, Janne M Papma, Yolande A L Pijnenburg, Anna Rubinski, Reinhold Schmidt, Eric E Smith, Rebecca M E Steketee, Esther van den Berg, Wiesje M van der Flier, Vikram Venkatraghavan, Narayanaswamy Venketasubramanian, Meike W Vernooij, Frank J Wolters, Xu Xin, Andreas Horn, Kaustubh R Patil, Simon B Eickhoff, Götz Thomalla, J Matthijs Biesbroek, Geert Jan Biessels, Bastian Cheng
INTRODUCTION: White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating cognitive health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH to these deficits remain unclear. We propose that lesion network mapping (LNM), enabling the inference of brain networks disconnected by lesions, represents a promising technique for enhancing our understanding of the role of WMH in cognitive disorders...
March 28, 2024: medRxiv
#16
JOURNAL ARTICLE
Gaotan Ke, Si Jian, Tingxin Yang, Xu Zhao
OBJECTIVES: To analyze the clinical and imaging characteristics of autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A). METHODS: Forty-three patients diagnosed with GFAP-A between March 2017 and July 2023 were retrospectively recruited. The clinical characteristics and magnetic resonance imaging (MRI) features were collected. RESULTS: Twenty-one patients (61.8%) had a fever and 16 (47.1%) had a headache. Five patients (14.7%) had coexisting neural autoantibodies and one patient (2...
2024: Frontiers in Neurology
#17
JOURNAL ARTICLE
Yachen Shi, Jingyu Deng, Haixia Mao, Yan Han, Qianqian Gao, Siyuan Zeng, Lin Ma, Wei Ji, Yang Li, Guangjun Xi, Lei Li, Yiping You, Junfei Shao, Kefei Chen, Xiangming Fang, Feng Wang
As the pathogenesis of cerebral small vessel disease with cognitive impairment (CSVD-CI) remains unclear, identifying effective biomarkers can contribute to the clinical management of CSVD-CI. This study recruited 54 healthy controls (HCs), 60 CSVD-CI patients, and 57 CSVD cognitively normal (CSVD-CN) patients. All participants underwent neuropsychological assessments and multimodal magnetic resonance imaging. Macrophage migration inhibitory factors (MIFs) were assessed in plasma. The least absolute shrinkage and selection operator model was used to determine a composite marker...
April 2, 2024: ACS Omega
#18
JOURNAL ARTICLE
Xiaofang Cheng, Quanhui Chen, Qiuxia Ren, Haoyuan Ma, Yan Zhao, Shusheng Jiao
BACKGROUND: Cerebral small vessel disease (CSVD) is prevalent in the population, especially among the elderly. Various types of CSVD markers commonly coexist, and the neurological function outcome is affected by their combined effect. Studies investigating the association between total CSVD burden and stroke outcomes in large vessel occlusion (LVO) stroke receiving endovascular treatment (EVT) are expanding but have not been systematically assessed. METHODS: We systematically searched the PubMed, Embase, and Cochrane databases for relevant clinical studies...
April 6, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
#19
JOURNAL ARTICLE
Neus Falgàs, Luca Sacchi, Tiziana Carandini, Nuria Montagut, Giorgio Conte, Fabio Triulzi, Daniela Galimberti, Andrea Arighi, Raquel Sanchez-Valle, Giorgio Giulio Fumagalli
INTRODUCTION: Differential diagnosis among subjects with Primary Progressive Aphasia (PPA) can be challenging. Structural MRI can support the clinical profile. Visual rating scales are a simple and reliable tool to assess brain atrophy in the clinical setting. The aims of the study were to establish to what extent the visual rating scales could be useful in the differential diagnosis of PPA, to compare the clinical diagnostic impressions derived from routine MRI interpretations with those obtained using the visual rating scale and to correlate results of the scales in a voxel-based morphometry (VBM) analysis...
April 6, 2024: Alzheimer's Research & Therapy
#20
JOURNAL ARTICLE
Min Chu, Deming Jiang, Haitian Nan, Lulu Wen, Li Liu, Miao Qu, Liyong Wu
BACKGROUND: Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in sporadic behavioral variant frontotemporal dementia (bvFTD) remains unclear. The aim of this study was to systematically explore vascular dysfunction, including changes in white matter hyperintensities (WMHs) and peripheral vascular markers in bvFTD. METHODS: Thirty-two patients with bvFTD who with no vascular risk factors were enrolled in this cross-sectional study and assessed using positron emission tomography/magnetic resonance (PET/MRI) imaging, peripheral plasma vascular/inflammation markers, and neuropsychological examinations...
April 5, 2024: Alzheimer's Research & Therapy
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
