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White matter hyperintensities

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https://www.readbyqxmd.com/read/28230421/medicare-expenditure-correlates-of-atrophy-and-cerebrovascular-disease-in-older-adults
#1
Briana S Last, Maria-José García Rubio, Carolyn W Zhu, Stephanie Cosentino, Jennifer J Manly, Charles DeCarli, Yaakov Stern, Adam M Brickman
: Background/Study Context: Magnetic resonance imaging (MRI) markers of cerebrovascular disease and atrophy are common in older adults and are associated with cognitive and medical burden. However, the extent to which they are related to health care expenditures has not been examined. We studied whether increased Medicare expenditures were associated with brain markers of atrophy and cerebrovascular disease in older adults. METHODS: A subset of participants (n = 592; mean age = 80 years; 66% women) from the Washington Heights Inwood Columbia Aging Project (WHICAP), a community-based observational study of aging in upper Manhattan, received high-resolution MRI and had Medicare expenditure data on file...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28228568/mri-visible-perivascular-spaces-in-cerebral-amyloid-angiopathy-and-hypertensive-arteriopathy
#2
Andreas Charidimou, Gregoire Boulouis, Marco Pasi, Eitan Auriel, Ellis S van Etten, Kellen Haley, Alison Ayres, Kristin M Schwab, Sergi Martinez-Ramirez, Joshua N Goldstein, Jonathan Rosand, Anand Viswanathan, Steven M Greenberg, M Edip Gurol
OBJECTIVE: To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different topographical patterns (in the centrum semiovale [CSO] and basal ganglia [BG]) in 2 common microangiopathies: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). METHODS: Consecutive patients with spontaneous intracerebral hemorrhage (ICH) from a prospective MRI cohort were included. Small vessel disease MRI markers, including cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), and white matter hyperintensities (WMH), were rated...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28226446/a-challenging-issue-detection-of-white-matter-hyperintensities-in-neonatal-brain-mri
#3
Baptiste Morel, Yongchao Xu, Alessio Virzi, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch, Baptiste Morel, Yongchao Xu, Alessio Virzi, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch, Alessio Virzi, Yongchao Xu, Thierry Geraud, Catherine Adamsbaum, Isabelle Bloch, Baptiste Morel
The progress of magnetic resonance imaging (MRI) allows for a precise exploration of the brain of premature infants at term equivalent age. The so-called DEHSI (diffuse excessive high signal intensity) of the white matter of premature brains remains a challenging issue in terms of definition, and thus of interpretation. We propose a semi-automatic detection and quantification method of white matter hyperintensities in MRI relying on morphological operators and max-tree representations, which constitutes a powerful tool to help radiologists to improve their interpretation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224419/a-retrospective-study-of-branch-atheromatous-disease-analyses-of-risk-factors-and-prognosis
#4
Yang Liu, Yuan-Teng Fan, Yu-Min Liu, Tao Wang, Hong-Liang Feng, Guang-Zhi Liu, Bin Mei
The theory of branch atheromatous disease (BAD) has been commonly underused in clinical practice and research since it was proposed in 1989. In this study, we sought to explore clinical characteristics of its substypes and biomarkers for prognosis of BAD. A total of 176 consecutive patients with BAD were classified into two groups: paramedianpontine artery group (PPA group, n=70) and lenticulostriate artery group (LSA group, n=106). Bivariate analyses were used to explore the relationship between white matter hyperintensities (WMHs), National Institutes of Health Stroke Scale (NIHSS) scores and prognosis evaluated by the modified Rank Scale (mRS) at 6th month after stroke...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28222778/sample-size-considerations-for-trials-using-cerebral-white-matter-hyperintensity-progression-as-an-intermediate-outcome-at-1%C3%A2-year-after-mild-stroke-results-of-a-prospective-cohort-study
#5
Francesca M Chappell, Maria Del Carmen Valdés Hernández, Stephen D Makin, Kirsten Shuler, Eleni Sakka, Martin S Dennis, Paul A Armitage, Susana Muñoz Maniega, Joanna M Wardlaw
BACKGROUND: White matter hyperintensities (WMHs) are commonly seen on in brain imaging and are associated with stroke and cognitive decline. Therefore, they may provide a relevant intermediate outcome in clinical trials. WMH can be measured as a volume or visually on the Fazekas scale. We investigated predictors of WMH progression and design of efficient studies using WMH volume and Fazekas score as an intermediate outcome. METHODS: We prospectively recruited 264 patients with mild ischaemic stroke and measured WMH volume, Fazekas score, age and cardiovascular risk factors at baseline and 1 year...
February 21, 2017: Trials
https://www.readbyqxmd.com/read/28222518/differential-regional-distribution-of-juxtacortical-white-matter-signal-abnormalities-in-aging-and-alzheimer-s-disease
#6
Emily R Lindemer, Douglas N Greve, Bruce Fischl, Jean C Augustinack, David H Salat
BACKGROUND: White matter signal abnormalities (WMSA) (also known as 'hyperintensities') on MRI are commonly seen in normal aging and increases have been noted in Alzheimer's disease (AD), but whether there is a spatial specificity to these increases is unknown. OBJECTIVE: To discern whether or not there is a spatial pattern of WMSA in the brains of individuals with AD that differs from those who exhibit cognitively healthy aging. METHOD: Structural MRI data from the Alzheimer's Disease Neuroimaging Initiative public database were used to quantify WMSA in 35 regions of interest (ROIs)...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222510/visuospatial-functioning-in-cerebral-amyloid-angiopathy-a-pilot-study
#7
Raffaella Valenti, Andreas Charidimou, Li Xiong, Gregoire Boulouis, Panagiotis Fotiadis, Alison Ayres, Grace Riley, Hugo J Kuijf, Yael D Reijmer, Leonardo Pantoni, M Edip Gurol, Sigurros Davidsdottir, Steven M Greenberg, Anand Viswanathan
Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23% on Benton Facial Recognition Test [BFRT] and 13.6% on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28217385/silent-ischemic-lesion-laterality-in-asymptomatic-internal-carotid-artery-stenosis-relates-to-reduced-cerebral-vasoreactivity
#8
Makoto Isozaki, Hiroharu Kataoka, Kazuhito Fukushima, Hatsue Ishibashi-Ueda, Naoaki Yamada, Hidehiro Iida, Koji Iihara
BACKGROUND: We investigated the relationship between silent ischemic lesions, defined as hyperintense lesions on T2-weighted magnetic resonance imaging scans of brain white matter and cerebral hemodynamics (baseline cerebral blood flow and cerebral vasoreactivity). METHODS: Between January 2007 and December 2012, 61 patients with asymptomatic internal carotid artery stenosis were evaluated for asymptomatic silent ischemic lesions, acute infarction, and cerebral hemodynamics...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28215260/moderate-to-severe-obstructive-sleep-apnea-is-associated-with-cerebral-small-vessel-disease
#9
Tae-Jin Song, Jung-Hyun Park, Kang Hyun Choi, Yoonkyung Chang, Jangsup Moon, Ju-Hee Kim, Yunseo Choi, Yong-Jae Kim, Hyang Woon Lee
BACKGROUND: Cerebral small vessel disease (SVD) is associated with increased risk of cerebral infarction and hemorrhage. Obstructive sleep apnea (OSA) is known to increase the risk of cerebrovascular disease. This study aimed to investigate the association between cerebral SVD and severity of OSA. METHODS: A total of 170 patients were included from the patient registry at the present Sleep Center; these patients underwent both magnetic resonance imaging (MRI) of the brain and polysomnography (PSG) for suspected OSA...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28208146/serum-lipid-fractions-and-cerebral-microbleeds-in-a-healthy-japanese-population
#10
Shingo Mitaki, Atsushi Nagai, Hiroaki Oguro, Shuhei Yamaguchi
BACKGROUND: Cerebral microbleeds (CMBs) are associated with focal hemosiderin deposits and represent a form of cerebral small vessel disease. To date, indefinite and inconsistent reports are available regarding the association between serum lipid fractions and CMBs. In addition, these previous studies did not include Asian populations, who may have a higher risk of cerebral hemorrhage. The purpose of this study was to examine the associations between serum lipid fractions and CMBs in healthy Japanese subjects...
February 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28208139/mri-based-neuroanatomical-predictors-of-dysphagia-dysarthria-and-aphasia-in-patients-with-first-acute-ischemic-stroke%C3%A2
#11
Heather L Flowers, Mohammed A AlHarbi, David Mikulis, Frank L Silver, Elizabeth Rochon, David Streiner, Rosemary Martino
BACKGROUND: Due to the high post-stroke frequency of dysphagia, dysarthria, and aphasia, we developed comprehensive neuroanatomical, clinical, and demographic models to predict their presence after acute ischemic stroke. METHODS: The sample included 160 randomly selected first-ever stroke patients with confirmed infarction on magnetic resonance imaging from 1 tertiary stroke center. We documented acute lesions within 12 neuroanatomical regions and their associated volumes...
February 16, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/28202818/-hypoglycemic-hemiplegia
#12
Eriko Sugawara, Yosuke Kudo, Ken Johkura
Hypoglycemia may cause acute hemiplegia. The most common diffusion-weighted MR imaging finding in patients with hypoglycemic hemiplegia is the hyperintense lesion involving the internal capsule, mimicking acute ischemic stroke. Thus, in patients with acute onset hemiplegia, it is important to differentiate hypoglycemia on arrival by immediate blood glucose measurement. It has recently been shown that hypoglycemic brain injury start in large white matter tracts such as internal capsule and spread throughout the whole brain, including the gray matter...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28196940/intravoxel-incoherent-motion-imaging-in-small-vessel-disease-microstructural-integrity-and-microvascular-perfusion-related-to-cognition
#13
C Eleana Zhang, Sau May Wong, Renske Uiterwijk, Julie Staals, Walter H Backes, Erik I Hoff, Tobien Schreuder, Cécile R L P N Jeukens, Jacobus F A Jansen, Robert J van Oostenbrugge
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously...
February 14, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28188307/early-life-risk-factors-for-cerebrovascular-disease-a-systematic-review-and-meta-analysis
#14
Ellen V Backhouse, Caroline A McHutchison, Vera Cvoro, Susan D Shenkin, Joanna M Wardlaw
OBJECTIVE: Cerebrovascular disease (CVD) causes subclinical brain vascular lesions detected using neuroimaging and childhood factors may increase later CVD risk. METHODS: We searched MEDLINE, PsycINFO, and EMBASE, and meta-analyzed all available evidence on childhood (premorbid) IQ, socioeconomic status (SES), education, and subclinical CVD in later life. Overall odds ratios (OR), mean difference or correlation, and 95% confidence intervals (CIs) were calculated using random effects methods...
February 10, 2017: Neurology
https://www.readbyqxmd.com/read/28180080/simultaneous-investigation-of-microvasculature-and-parenchyma-in-cerebral-small-vessel-disease-using-intravoxel-incoherent-motion-imaging
#15
Sau May Wong, C Eleana Zhang, Frank C G van Bussel, Julie Staals, Cécile R L P N Jeukens, Paul A M Hofman, Robert J van Oostenbrugge, Walter H Backes, Jacobus F A Jansen
INTRODUCTION: Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD to assess the microvasculature and parenchymal microstructure. METHODS: Seventy-three patients with cSVD (age 70 ± 11 y) and thirty-nine controls (age 69 ± 12 y) underwent IVIM imaging (3T)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28174033/acute-hypotonia-in-an-infant
#16
Jimme Sierakowski, Jason Arthur, Todd Wylie
BACKGROUND: Acute flaccid myelitis (AFM) is increasing in incidence in the United States and presenting to emergency departments (EDs) across the country. This clinical entity presents as acute paralysis, with magnetic resonance imaging changes in the gray matter only in children younger than 21 years of age. The etiology is unknown, although preceding viral illnesses are common. There are no consensus guidelines regarding treatment. CASE REPORT: A 4-month-old girl presented with decreased bilateral arm movement...
February 4, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28169884/mri-progression-of-cerebral-small-vessel-disease-and-cognitive-decline-in-patients-with-hypertension
#17
Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W de Leeuw, Abraham A Kroon, Robert J van Oostenbrugge
OBJECTIVE: Hypertension is associated with cognitive deficits, probably because it is a major risk factor for the development of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds, which are MRI markers of cerebral small vessel disease. Studies into associations between presence or progression of these MRI markers and cognitive decline in hypertensive patients are rare. We investigated the association of baseline presence and progression of MRI markers of cerebral small vessel disease with cognitive decline over 4 years in patients with hypertension...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28168372/high-b-value-diffusion-weighted-imaging-in-progressive-multifocal-leukoencephalopathy-in-hiv-patients
#18
Claudia Godi, Enrico De Vita, Enrico Tombetti, Indran Davagnanam, Lewis Haddow, Hans Rolf Jäger
OBJECTIVES: An ill-defined hyperintense edge and hypointense core on diffusion-weighted imaging (DWI) is typical of progressive multifocal leukoencephalopathy (PML). We aimed to investigate whether a b-value of 3,000 s/mm(2) (b3000) can improve visualisation of PML, or provide different structural information compared to 1,000 s/mm(2) (b1000). METHODS: We retrospectively identified HIV-positive patients with confirmed PML studied under a clinical protocol including both b1000 and b3000 DWI...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28166312/association-between-subclinical-cardiac-biomarkers-and-clinically-manifest-cardiac-diseases-with-cortical-cerebral-microinfarcts
#19
Saima Hilal, Yuek Ling Chai, Susanne van Veluw, Muhammad Amin Shaik, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Arthur Mark Richards, Geert Jan Biessels, Christopher Chen
Importance: Subclinical and clinical cardiac diseases have been previously linked to magnetic resonance imaging (MRI) manifestations of cerebrovascular disease, such as lacunes and white matter hyperintensities, as well as dementia. Cortical cerebral microinfarcts (CMIs), a novel MRI marker of cerebral vascular disease, have not been studied, to date, in relation to subclinical and clinical cardiac diseases. Objective: To examine the association of blood biomarkers of subclinical cardiac disease and clinically manifest cardiac diseases with CMIs graded on 3-T MRI in a memory clinic population...
February 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28157096/only-white-matter-hyperintensities-predicts-post-stroke-cognitive-performances-among-cerebral-small-vessel-disease-markers-results-from-the-tabasco-study
#20
Jeremy Molad, Efrat Kliper, Amos D Korczyn, Einor Ben Assayag, Dafna Ben Bashat, Shani Shenhar-Tsarfaty, Orna Aizenstein, Ludmila Shopin, Natan M Bornstein, Eitan Auriel
BACKGROUND: White matter hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA). However, WMH are only one among other radiological markers of cerebral small vessel disease (SVD). OBJECTIVE: The aim of this study was to determine whether adding other SVD markers to WMH improves prediction of post-stroke cognitive performances. METHODS: Consecutive first-ever stroke or TIA patients (n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) study were enrolled...
February 1, 2017: Journal of Alzheimer's Disease: JAD
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