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Borderline ovarian tumor lymph node

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https://www.readbyqxmd.com/read/29680231/accuracy-of-intraoperative-frozen-section-diagnosis-of-borderline-ovarian-tumors-by-hospital-type
#1
Jaimin Shah, Michael Mackelvie, David M Gershenson, Preetha Ramalingam, Marylee M Kott, Jubilee Brown, Polly Gauthier, Elizabeth Nugent, Lois M Ramondetta, M Frumovitz
STUDY OBJECTIVE: To compare the accuracy of frozen section diagnosis of borderline ovarian tumors among three distinct types of hospital-academic hospital with gynecologic pathologists, academic hospital with non-gynecologic pathologists, and community hospital with non-gynecologic pathologists-and to determine if surgical staging alters patient care or outcomes for women with a frozen section diagnosis of borderline ovarian tumor. DESIGN: Retrospective study DESIGN CLASSIFICATION: Level II1 SETTING: Tertiary care, academic, and community hospitals PATIENTS: Women with an intraoperative frozen section diagnosis of borderline ovarian tumor at one of the aforementioned three types of hospital from April 1998 through June 2016...
April 19, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29581788/increased-he4-mrna-expression-correlates-with-high-level-of-eif3a-mrna-and-better-survival-in-women-with-epithelial-ovarian-cancer
#2
Chen-Hui Luo, Min Zhao, Yu-Xi Tang, Shohreh Shahabi, Kai-Ning Fang, Yan Chen, Yan Tang, Xiao-Yan Chen, Jing Wang, Hong-Hao Zhou
Human epididymis protein 4 (HE4) is one of the most promising biomarkers for epithelial ovarian cancer (EOC). The majority of previous studies utilized the serum level or tissue protein expression of HE4 based upon immunohistochemistry (IHC) to evaluate the role of HE4 in the diagnosis, prognosis, and surveillance of EOC, but very little is known about HE4 mRNA expression. Eukaryotic translation initiation factor 3a (eIF3a) is implicated in oncogenesis and has been investigated extensively as a potential biomarker for malignancy...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29194193/clinical-predictors-of-recurrence-and-prognostic-value-of-lymph-node-involvement-in-the-serous-borderline-ovarian-tumor
#3
Xue-Qian Qian, Xiao-Ping Hua, Juan-Hong Wu, Yuan-Ming Shen, Xiao-Dong Cheng, Xiao-Yun Wan
AIM: This study was aimed to evaluate the risk factors of recurrence and the value of nodal involvement in patients with serous borderline ovarian tumors (SBOT). METHODS: Two hundred twenty-five patients who underwent surgery and were diagnosed with SBOT were retrospectively studied. Univariate and multivariate analyses were used to assess the risk factors for recurrence. Patients' clinical pathologic characteristics were compared between the patients who presented lymph node involvement and those who did not...
February 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29194190/an-evaluation-of-frozen-section-and-lymph-node-dissection-results-for-mucinous-ovarian-tumors
#4
Marisa R Moroney, Miriam D Post, Amber A Berning, Jeanelle Sheeder, Bradley R Corr
OBJECTIVES: Intraoperative frozen section has greater than 90% accuracy for ovarian tumors; however, mucinous histology has been shown to be associated with increased frozen section inaccuracy. Recent data demonstrate that primary ovarian mucinous carcinomas have no lymph node involvement, even when extraovarian disease is present, and therefore may not require lymph node dissection. Our primary objective is to evaluate the accuracy of identifying mucinous histology on frozen section...
January 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29192414/outcomes-of-patients-with-advanced-stage-ovarian-cancer-with-intestinal-metastasis
#5
Eyüp Kebapcı, Varol Gülseren, Cem Tuğmen, Mehmet Gökçü, Ulaş Solmaz, İsmail Sert, Mustafa Kocaer, Mehmet Özer, Mustafa Ölmez, Muzaffer Sancı
OBJECTIVES: The aim of this study is to evaluate the results of advanced stage (stage IIIB-IVB) ovarian cancer (OC) patients with intestinal metastasis, and to investigate the factors that affect survival. MATERIAL AND METHODS: Patients who underwent cytoreductive surgery (CS) for FIGO stage IIIB-IVB OC with metastasis in the intestinal system, at Tepecik Research and Treatment Hospital between 2008-2014, were analyzed retrospectively. Patients with borderline ovarian tumor; those who had previously undergone radiation therapy and/or hysterectomy and patients having secondary or tertiary cytoreduction were excluded and 49 patients were included and analyzed in this study...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28804555/imp3-is-upregulated-in-primary-ovarian-mucinous-carcinoma-and-promotes-tumor-progression
#6
Qin Zhu, Yuqing Qu, Qiongyan Zhang, Linghui Lu, Weiwei Weng, Hao Zhang, Lihong Zhang, Yan Ning, Yiqin Wang
OBJECTIVE: Primary ovarian mucinous tumors progress from benign adenoma to borderline tumors to invasive mucinous carcinoma. A proper differential diagnosis is crucial to discriminate malignancies at the early stages of disease. However, few biomarkers are clinically available. We designed this study to analyze the clinical application of the oncogene IMP3 in monitoring early malignancies in ovarian primary mucinous tumors. METHODS: We collected 250 samples of ovarian primary mucinous tumors along with the corresponding clinicopathological information between 2009 and 2015 at the Gynecology and Obstetrics Hospital of Fudan University and performed immunochemical assays...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28612563/-expression-and-clinical-significance-of-numb-and-p53-proteins-in-epithelial-ovarian-carcinoma
#7
Min Xu, Hong-Ju He, Huan Zhang, Ao Wang, Jie Chen
OBJECTIVES: To investigate the expression and clinical significance of Numb and P53 proteins in epithelial ovarian carcinoma. METHODS: We co-tested the expressions of Numb and P53 proteins in epithelial ovarian tissues by immunohistochemistry, including 20 cases of normal tissues, 29 cases of benign tumors, 35 cases of borderline ovarian tumors and 87 cases of epithelial ovarian carcinoma. Their clinical significance was analyzed. RESULTS: The positive expression rates of Numb protein in normal ovarian tissues, benign ovarian tumors, borderline ovarian tumors and epithelial ovarian carcinoma were 5%, 13...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28598117/-expression-level-of-membrane-associated-proteins-numb-in-epithelial-ovarian-carcinoma-and-its-relationship
#8
Hong Jing, Xiao-Yu Liu, Ya-Li Chen, Li-Ping Bai, Ai Zheng
OBJECTIVES: To explore the expression level of membrane-associated protein Numb in epithelial ovarian carcinoma and its relationship with ovarian cancer stem cell markers CD117,CD133,acetaldehyde dehydrogenase 1(ALDH1). METHODS: A total of 136 patients who had ovarian tumors and 22 patients who had not ovarian tumors in Department of Gynaecology and Obstetrics,West China Second University Hospital,Sichuan University were chosen as the study subjects.According to the histopathologic examination results,they were divided into epithelial ovarian carcinoma group (n=92),ovarian borderline tumor group (n=23),ovarian benign tumor group (n=21) and normal ovary group (n=22)...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28025670/ovarian-borderline-tumors-in-the-2014-who-classification-evolving-concepts-and-diagnostic-criteria
#9
REVIEW
Steffen Hauptmann, Katrin Friedrich, Raymond Redline, Stefanie Avril
Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. Since BOT were first identified >40 years ago, they have inspired controversies disproportionate to their incidence. This review discusses diagnostic criteria for the histologic subtypes of BOT, highlighting areas of diagnostic challenges, ongoing controversies, and changes in terminology implemented by the recent 2014 WHO Classification of Tumours of the Female Genital Organs...
February 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27756415/borderline-ovarian-tumors-clinical-characteristics-management-and-outcomes-a-multicenter-study
#10
MULTICENTER STUDY
Mehmet Gokcu, Kemal Gungorduk, Osman Aşıcıoğlu, Nilüfer Çetinkaya, Tayfun Güngör, Gonca Pakay, Zeliha Fırat Cüylan, Tayfun Toptaş, Ramazan Özyurt, Elif Ağaçayak, Aykut Ozdemir, Onur Erol, Anıl Turan, Varol Gülseren, Mehmet Sait İcen, Taylan Şenol, Hakan Güraslan, Burcu Yücesoy, Ahmet Sahbaz, Ozgu Gungorduk, Berhan Besimoğlu, Kaan Pakay, Osman Temizkan, Muzaffer Sancı, Tayup Şimşek, Mehmet Mutlu Meydanlı, Mehmet Harma, Levent Yaşar, Birtan Boran, Aysel Derbent Uysal, Ateş Karateke
BACKGROUND: The optimal surgical management and staging of borderline ovarian tumors (BOTs) are controversial. Institutions have different surgical approaches for the treatment of BOTs. Here, we performed a retrospective review of clinical characteristics, surgical management and surgical outcomes, and sought to identify variables affecting disease-free survival (DFS) and overall survival (OS) in patients with BOTs. METHODS: A retrospective review of ten gynecological oncology department databases in Turkey was conducted to identify patients diagnosed with BOTs...
October 18, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27604260/lymphatic-mapping-and-sentinel-node-biopsy-in-ovarian-tumors-a-study-using-intra-operative-tc-99m-phytate-and-lymphoscintigraphy-imaging
#11
Malihe Hassanzadeh, Elham Hosseini Farahabadi, Zohreh Yousefi, Sima Kadkhodayan, Leili Zarifmahmoudi, Ramin Sadeghi
BACKGROUND: Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. METHODS: Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study. The radiotracer was injected just after laparotomy and before removal of the tumor either beneath the normal cortex (10 patients) or in the utero-ovarian and suspensory ligaments of the ovary just beneath the peritoneum two injections of the radiotracer (25 patients)...
September 7, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27563339/fine-needle-aspiration-cytology-of-cervical-lymph-node-involvement-by-ovarian-serous-borderline-tumor
#12
Longwen Chen, Kristina A Butler, Debra A Bell
Serous borderline tumor (SBT) involving a cervical lymph node is extremely rare. In addition, fine needle aspiration (FNA) cytology of the involved cervical lymph node shares tremendous morphologic similarity with other low-grade papillary carcinomas. Thus, it can be easily misdiagnosed as metastatic carcinoma. A 42-year-old female had a history of bilateral SBT and postbilateral salpingo-oophorectomy. She presented with left cervical lymphadenopathy 6 months later. FNA cytology showed a low-grade papillary neoplasm with psammoma bodies...
2016: CytoJournal
https://www.readbyqxmd.com/read/27446467/overexpression-of-rab27b-is-correlated-with-distant-metastasis-and-poor-prognosis-in-ovarian-cancer
#13
Ping Ren, Xiao-Qing Yang, Xiao-Lu Zhai, Yu-Quan Zhang, Jian-Fei Huang
The secretory small guanosine-5'-triphosphate-binding enzyme, Rab27B, has been identified to be an oncogene that is involved in the progression of certain tumors. The current study was designed to evaluate the expression pattern of Rab27B in ovarian cancer (OC), borderline tumors and benign ovarian adenoid tumors, as well as its association with survival prognosis and clinical parameters. The expression of Rab27B protein was examined by immunohistochemistry in 204 patients who had undergone ovarian resection without preoperative systemic chemotherapy at the Surgical Department of the Affiliated Hospital of Nantong University (Nantong, China), including 57 benign ovarian adenoid tumors, 44 borderline tumors and 103 malignant tumors...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27428735/classification-of-extraovarian-implants-in-patients-with-ovarian-serous-borderline-tumors-tumors-of-low-malignant-potential-based-on-clinical-outcome
#14
Jesse K McKenney, C Blake Gilks, Steve Kalloger, Teri A Longacre
The classification of extraovarian disease into invasive and noninvasive implants predicts patient outcome in patients with high-stage ovarian serous borderline tumors (tumors of low malignant potential). However, the morphologic criteria used to classify implants vary between studies. To date, there has been no large-scale study with follow-up data comparing the prognostic significance of competing criteria. Peritoneal and/or lymph node implants from 181 patients with high-stage serous borderline tumors were evaluated independently by 3 pathologists for the following 8 morphologic features: micropapillary architecture; glandular architecture; nests of epithelial cells with surrounding retraction artifact set in densely fibrotic stroma; low-power destructive tissue invasion; single eosinophilic epithelial cells within desmoplastic stroma; mitotic activity; nuclear pleomorphism; and nucleoli...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27172753/ovarian-large-cell-neuroendocrine-carcinoma-in-the-youngest-woman
#15
Y S Kwon, K S Im, D I Choi
Large cell neuroendocrine carcinoma (LCNC) of the ovary is a rare tumor in gynecologic oncologic field. An 18-year-old woman presented with abdominal distention and a pelvic mass measuring ten cm in diameter, who previously underwent laparoscopic ovarian cystectomy due to large borderline mucinous ovarian neoplasm 18 months prior. A debulking operation was optimally performed, which included total abdominal hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, bilateral paraaortic lymph node dissection, omentectomy, optimal debulking of gastrohepatic mass and subdiaphragmatic mass, and pelvic peritonectomy...
2016: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/27052022/clinicopathologic-features-of-ovarian-neoplasms-with-emphasis-on-borderline-ovarian-tumors-an-institutional-perspective
#16
Atif Ali Hashmi, Zubaida Fida Hussain, Aneel Roy Bhagwani, Muhammad Muzzammil Edhi, Naveen Faridi, Syed Danish Hussain, Mehmood Khan
BACKGROUND: Ovarian cancer is the most lethal gynecologic malignancy and it represents third most common malignancy in Karachi (after breast and oral cancer). Due to lack of well established cancer registry in our country, changing trends of ovarian tumors has not been determined. Therefore we aimed to establish the current trends and classification of ovarian tumors in our setup according to latest WHO guidelines. METHODS: We retrospectively analyzed 162 cases of ovarian tumors that underwent surgical resection from January 2009 till December 2014...
April 6, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/26815661/survivin-and-cycline-d1-expressions-are-associated-with-malignant-potential-in-mucinous-ovarian-neoplasms
#17
Mehmet Kanter, Gulay Turan, Ceyda Usta, Akin Usta, H Hasan Esen, Lema Tavlı, Cetin Celik, Yusuf Demirkol, Betül Kanter
The most prevalent malignant ovarian neoplasms are epithelial ovarian cancers which is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of survivin and cycline D1 biomarkers in mucinous ovarian neoplasms and their correlations with clinicopathological variables in mucinous ovarian cancers. We analyzed pathological specimens of 98 patients with benign (n = 34), borderline (n = 22) and malignant (n = 42) mucinous ovarian neoplasms...
April 2016: Journal of Molecular Histology
https://www.readbyqxmd.com/read/26675395/-protein-levels-and-its-clinical-significance-of-septin-9-and-clusterin-in-peripheral-blood-of-epithelial-ovarian-cancer-patients
#18
Nenan Lyu, Hongwen Yao, Ting Xiao, Yanning Gao, Lingying Wu
OBJECTIVE: To evaluate septin-9 and clusterin protein levels in the peripheral blood samples from epithelial ovarian cancer patients, and explore its clinical significance. METHODS: Clinical data of 200 patients in Cancer Hospital, Chinese Academy of Medical Sciences from Jan. 29, 2008 to Feb. 1, 2010 were collected. The peripheral blood samples were obtained from 137 epithelial ovarian cancer patients, 12 borderline ovarian tumor patients, 10 benign ovarian tumor patients, 41 benign pelvic lesion patients and 58 healthy women...
September 2015: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/26646473/clinically-occult-primary-fallopian-tube-carcinoma-presenting-as-a-malignant-pleural-effusion
#19
Robert Hiensch, Klaus Meinhof, Anatoly Leytin, George Hagopian, Eva Szemraj, Oleg Epelbaum
We report the first known case of malignant pleural effusion (MPE) as the sole presenting feature of clinically occult primary fallopian tube carcinoma (PFTC). A 57-year-old healthy woman was admitted with dyspnea. Evaluation demonstrated a right pleural effusion, fluid of which was malignant. The immunohistochemical profile, including negative calretinin, favored metastatic adenocarcinoma over mesothelioma but could not identify the primary tumor site. Pleural biopsy was not pursued as it would not have helped localize the primary...
December 8, 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26609483/lewis-y-antigen-modified-cd47-is-an-independent-risk-factor-for-poor-prognosis-and-promotes-early-ovarian-cancer-metastasis
#20
Mingzi Tan, Liancheng Zhu, Huiyu Zhuang, Yingying Hao, Song Gao, Shuice Liu, Qing Liu, Dawo Liu, Juanjuan Liu, Bei Lin
CD47 is a membrane receptor that belongs to the immunoglobulin superfamily and plays an important role in the mechanisms of tumor immune escape. CD47 participates in tumor immune escape by combining with SIRPα to reduce the phagocytic activity of macrophages. There are six potential N-glycosylation sites on CD47, and glycosylation is known to be necessary for its membrane localization. However, it is still unknown to what extent glycosylation influences CD47 ligand binding properties and subsequent signaling...
2015: American Journal of Cancer Research
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