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https://www.readbyqxmd.com/read/29684368/order-of-draw-practices-in-venous-blood-sampling-at-clinical-biochemistry-departments-in-the-danish-health-care-system
#1
Katja Kemp Jacobsen, Ida Brandt, Anne Vindahl Christensen, Bjørk Anine Rimsø, Camilla Julie Krøier, Michelle Sørensen, Julie Smith, Kathrine Overgaard Foss Jensen, Jeppe Madura Larsen
BACKGROUND: Deviation in blood collection procedures is a central source of preanalytical variation affecting overall analytical and diagnostic precision. The order of draw of venous sampling is suspected to affect analytical results, in particular for coagulation analysis. Here we compare the procedures in venous blood sampling among clinical biochemistry departments to assess the uniformity of order of blood draw and adherence to international guidelines in the Danish health care system...
April 20, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29684356/clinical-laboratorial-and-immunological-aspects-of-severe-malaria-in-children-from-guinea-bissau
#2
Janine Domingos, Anaxore Casimiro, Daniela Portugal-Calisto, Luís Varandas, Fátima Nogueira, Marcelo Sousa Silva
Malaria is a parasitic disease of which Plasmodium falciparum causes the most severe form of the disease. The immune response against Plasmodium spp. is complex and remains unclear. The present report aimed to better understand the humoral immune response in severe malaria and analyse new immunodominant antigen candidates as possible serological marker in severe malaria in children. This study included children aged 0-16 years from Guinea-Bissau with clinical signs of severe malaria. Serological and immunochemical characterisation of different anti-P...
April 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29684201/dysregulation-of-epstein-barr-virus-infection-in-hypomorphic-zap70-mutation
#3
Akihiro Hoshino, Takehiro Takashima, Kenichi Yoshida, Akira Morimoto, Yuta Kawahara, Tzu-Wen Yeh, Tsubasa Okano, Motoi Yamashita, Noriko Mitsuiki, Kohsuke Imai, Takashi Sakatani, Atsuko Nakazawa, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Tomohiro Morio, Hirokazu Kanegane
Background: Some patients with genetic defects develop Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD)/lymphoma as the main feature. Hypomophic mutations can cause different clinical and laboratory manifestations from null mutations in the same genes. Methods: We sought to describe the clinical and immunologic phenotype of a 21-month-old boy having EBV-associated LPD who was in good health till then. A genetic and immunologic analysis was performed...
April 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29684118/spontaneous-endometriosis-in-cynomolgus-monkeys-as-a-clinically-relevant-experimental-model
#4
A Nishimoto-Kakiuchi, S Netsu, S Okabayashi, K Taniguchi, H Tanimura, A Kato, M Suzuki, T Sankai, R Konno
STUDY QUESTION: Does spontaneous endometriosis in cynomolgus monkeys have the characteristics required of a good experimental model? SUMMARY ANSWER: Spontaneous endometriosis in cynomolgus monkeys exhibited similar clinicopathological characteristics to the human disease and was useful as an experimental model. WHAT IS KNOWN ALREADY: The prevalence of endometriosis in autopsied cynomolgus monkeys (Macaca fascicularis) in a breeding colony was reported to be 28...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684090/predictors-of-poor-outcome-in-patients-with-pulmonary-arterial-hypertension-a-single-center-study
#5
Emilia Stepnowska, Ewa Lewicka, Alicja Dąbrowska-Kugacka, Ludmiła Daniłowicz-Szymanowicz, Paweł Zagożdżon, Rafał Kamiński, Zuzanna Lewicka-Potocka, Paweł Miękus, Dariusz Kozłowski, Wojciech Potocki, Grzegorz Raczak
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a rare disorder with unfavorable prognosis despite implementation of specific PAH-oriented therapy. The aim of the study was to define predictors of poor prognosis in patients from one center treated according to the Polish National Health Fund program. PATIENTS AND METHODS: Forty-seven consecutive patients (30 women; aged 39±17 years) with PAH diagnosis were enrolled to the study. Clinical assessment, laboratory measurements, electrocardiogram, echocardiography, 6-minute walk test, 24-hour Holter monitoring, cardiopulmonary exercise test and microvolt T-wave alternans test were performed during routine visits...
2018: PloS One
https://www.readbyqxmd.com/read/29683954/a-retrospective-analysis-of-sociodemographic-and-hematologic-characteristics-associated-with-achieving-optimal-hydroxyurea-therapy-in-children-with-sickle-cell-disease
#6
Paul E George, Juan C Bazo-Alvarez, Vivien A Sheehan
Hydroxyurea (HU) has proven hematologic and clinical benefits, especially when escalated to the maximum tolerated dose (MTD). We reviewed clinical data from patients with sickle cell disease (January 2011 to 2016) to determine baseline sociodemographic and laboratory parameters associated with reaching HU MTD without significant delays. In total, 210 patients (mean HU start age, 6.6 y) were included. Initial Kaplan-Meier event analysis showed 1 year to be an inflection point for reaching MTD. In total, 116 patients (55%) reached MTD in <1 year, with 56 (27%) taking >1 year to reach MTD and 38 (18%) patients not successfully reaching MTD during follow-up...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683919/hiit-in-the-real-world-outcomes-from-a-12-month-intervention-in-overweight-adults
#7
Melyssa Roy, Sheila M Williams, Rachel C Brown, Kim A Meredith-Jones, Hamish Osborne, Michelle Jospe, Rachael W Taylor
PURPOSE: Although high-intensity interval training (HIIT) and moderate-intensity continuous exercise have comparable health outcomes in the laboratory setting, effectiveness studies in real-world environments are lacking. The aim of this study was to determine the effectiveness of an unsupervised HIIT programme in overweight/obese adults over 12 months. METHODS: 250 overweight/obese adults could choose HIIT or current exercise guidelines of 30 minutes/day moderate-intensity exercise...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683797/uncertainty-evaluation-in-clinical-chemistry-immunoassay-hematology-and-coagulation-analytes-using-only-external-quality-assessment-data
#8
Yanyan Qin, Rui Zhou, Wei Wang, Hongyi Yin, Yanmin Yang, Yuhong Yue, Qing Tong, Lu Liu, Yali Jin, Yankun Shi, Shunli Zhang, Jianping Zhang, Rui Zhang, Chang Zuo, Tingting Jia, Ning Wang, Qingtao Wang
BACKGROUND: Measurement uncertainty (MU) is a parameter associated with the result of a measurement that characterizes its dispersion. We report results for estimating MU following the application of a top-down procedure using only proficiency test data to establish uncertainty levels for various analytes. METHODS: Data were obtained from 142 laboratories participating in the Beijing Center for Clinical Laboratory (BCCL) proficiency testing/external quality assessment (PT/EQA) schemes...
April 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29683226/low-incidence-of-heparin-induced-skin-lesions-in-orthopedic-surgery-patients-with-low-molecular-weight-heparins
#9
M Schindewolf, M Paulik, H Kroll, R Kaufmann, M Wolter, W-H Boehncke, E Lindhoff-Last, A Recke, R J Ludwig
BACKGROUND: Heparins are widely prescribed for prevention and therapy of arterial and venous thromboembolic diseases. Heparin-induced skin lesions are the most frequent adverse effects of subcutaneous heparin treatment in non-surgical patients (7.5-39.8%); no data exist on surgical patients. Commonly, they are due to a delayed-type hypersensitivity reaction (DTH), but may also be a manifestation of life-threatening heparin-induced thrombocytopenia (HIT). Lesions of both entities resemble initially...
April 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29683224/evaluating-the-role-of-subacromial-impingement-in-rotator-cuff-tendinopathy-development-and-analysis-of-a-novel-murine-model
#10
Guang-Ting Cong, Amir H Lebaschi, Christopher L Camp, Camila B Carballo, Yusuke Nakagawa, Susumu Wada, Xiang-Hua Deng, Scott A Rodeo
Subacromial impingement of the rotator cuff is understood as a contributing factor in the development of rotator cuff tendinopathy. However, changes that occur in the impinged tendon are poorly understood and warrant further study. To enable further study of rotator cuff tendinopathy, we performed a controlled laboratory study to determine feasibility and baseline characteristics of a new murine model for subacromial impingement. This model involves surgically inserting a microvascular clip into the subacromial space in adult C57Bl/6 mice...
April 23, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29683194/clinical-experience-with-multigene-carrier-panels-in-the-reproductive-setting
#11
Catherine Terhaar, Nicole Teed, Rachel Allen, Lindsay Dohany, Christina Settler, Carol Holland, Ryan E Longman
OBJECTIVES: Expanded carrier testing is acknowledged as an acceptable strategy for carrier testing by the American College of Obstetrics and Gynecology. Limited studies have investigated positivity rates of expanded carrier panels. We describe our experience with three commercial laboratory panels varying in size from 3 to 218 disorders. METHODS: We reviewed outcomes for three multigene carrier screening panels: Trio (3 diseases), Standard (23 diseases), and Global (218 diseases)...
April 23, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29682837/massive-transfusion-changing-practice-in-a-single-norwegian-centre-2002-2015
#12
H Doughty, T O Apelseth, J Sivertsen, K Annaniasen, T Hervig
OBJECTIVES: To describe the change in massive transfusion (MT) practice in a single Norwegian centre throughout the period 2002-2015. BACKGROUND: MT support for traumatic haemorrhage has changed since the mid-2000s. However, life-threatening haemorrhage may occur in other clinical specialties. In 2007, Haukeland University Hospital (HUS) introduced a universal MT programme including education, Acute Transfusion Packages (ATPs) and thromboelastography. METHODS/MATERIALS: A retrospective review was performed of all MT episodes defined as ≥10 red cell concentrates (RCC) in 24 h...
April 23, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29682796/phase-2a-randomized-double-blind-placebo-controlled-multicenter-parallel-group-study-of-an-h-4-r-antagonist-jnj-39758979-in-adults-with-uncontrolled-asthma
#13
Alexa P Kollmeier, Andrew Greenspan, Xie L Xu, Philip E Silkoff, Elliot Barnathan, Matthew J Loza, Jingzhi Jiang, Bei Zhou, Bin Chen, Robin L Thurmond
BACKGROUND: The effects of H4 R antagonists in preclinical asthma models support the study of antagonists of the H4 R in the treatment of asthma in humans. JNJ-39758979 is a potent and highly-selective oral H4 R antagonist. OBJECTIVE: We sought to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult patients with uncontrolled asthma. METHODS: One hundred and fifteen eligible patients were randomly assigned to JNJ-39758979 300 mg or placebo once daily for 12 weeks in this phase 2a, double-blind, multicenter, placebo-controlled study...
April 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29682788/dot-enzyme-linked-immunosorbent-assay-strip-as-a-screening-tool-for-detection-of-autoantibody-to-interferon-gamma-in-sera-of-suspected-cases-of-adult-onset-immunodeficiency
#14
Kritsadee Rattanathammethee, Kriangkrai Chawansuntati, Romanee Chaiwarith, Jutarat Praparattanapan, Khuanchai Supparatpinyo, Jiraprapa Wipasa
BACKGROUND: Being able to detect the presence of autoantibodies to interferon (IFN)-γ in serum is essential for evaluating patients with suspected adult-onset immunodeficiency (AOID) with unusual intracellular infections. Most reported patients with AOID have been Asian, although the exact prevalence of this illness is unknown. To date, no standard assay exists to detect autoantibodies to IFN-γ. An easy-to-use, low-cost assay that can be performed in any laboratory would be a valuable tool for clinical management of AOID, as well as better reveal its prevalence...
April 22, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29682619/path-of-least-resistance-how-computerised-provider-order-entry-can-lead-to-and-reduce-wasteful-practices
#15
Joseph Choi, Cori Rebecca Atlin
Background: Computerised provider order entry (CPOE) is rapidly becoming the mainstay in clinical care and has the potential to improve provider efficiency and accuracy. However, this hinges on careful planning and implementation. Poorly planned CPOE order sets can lead to undetected errors and waste. In our emergency department (ED), lactate dehydrogenase (LDH) was bundled into various blood work panels but had little clinical value. Objectives: This quality improvement initiative aimed to reduce unnecessary LDH testing in the ED...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29682608/-hallucinations-following-acute-cannabis-dosing-a-case-report-and-comparison-to-other-hallucinogenic-drugs
#16
Frederick S Barrett, Nicolas J Schlienz, Natalie Lembeck, Muhammad Waqas, Ryan Vandrey
Introduction: Cannabis has been historically classified as a hallucinogen. However, subjective cannabis effects do not typically include hallucinogen-like effects. Empirical reports of hallucinogen-like effects produced by cannabis in controlled settings, particularly among healthy research volunteers, are rare and have mostly occurred after administration of purified Δ-9 tetrahydrocannabinol (THC) rather than whole plant cannabis. Methods: The case of a healthy 30-year-old male who experienced auditory and visual hallucinations in a controlled laboratory study after inhaling vaporized cannabis that contained 25 mg THC (case dose) is presented...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29682451/cerebro-facio-thoracic-dysplasia-pascual-castroviejo-syndrome-identification-of-a-novel-mutation-use-of-facial-recognition-analysis-and-review-of-the-literature
#17
Jennifer A F Tender, Carlos R Ferreira
BACKGROUND: Cerebro-facio-thoracic dysplasia (CFTD) is a rare, autosomal recessive disorder characterized by facial dysmorphism, cognitive impairment and distinct skeletal anomalies and has been linked to the TMCO1 defect syndrome. OBJECTIVE: To describe two siblings with features consistent with CFTD with a novel homozygous p.Arg114* pathogenic variant in the TMCO1 gene. METHODS: We conducted a literature review and summarized the clinical features and laboratory results of two siblings with a novel pathogenic variant in the TMCO1 gene...
April 13, 2018: Translational Science of Rare Diseases
https://www.readbyqxmd.com/read/29682429/when-why-and-how-foot-orthoses-fos-should-be-prescribed-for-children-with-flexible-pes-planus-a-delphi-survey-of-podiatrists
#18
Sindhrani Dars, Hayley Uden, Saravana Kumar, Helen A Banwell
Background: Flexible pes planus (flat feet) in children is a common reason parents and caregivers seek health professionals consult and a frequent reason podiatrists prescribe foot orthoses. Yet no universal agreement exists on the diagnosis of this condition, or when and how foot orthoses should be prescribed. The aim of this study was to garner consensus and agreement among podiatrists on the use of FOs for paediatric flexible pes planus. Methods: A three round Delphi consensus survey was undertaken with 15 podiatry experts from Australia, New Zealand and the United Kingdom...
2018: PeerJ
https://www.readbyqxmd.com/read/29682419/inducible-nitric-oxide-synthase-nos2-knockout-mice-as-a-model-of-trichotillomania
#19
Plinio C Casarotto, Caroline Biojone, Karina Montezuma, Fernando Q Cunha, Samia R L Joca, Eero Castren, Francisco S Guimaraes
Background: Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal hyperactivity and hypoactivation of the prefrontal cortex. Methods: In this study, we evaluated the BB in knockout mice for the inducible isoform of nitric oxide synthase (NOS2KO) and the consequences of silencing this enzyme in PC12 cell differentiation...
2018: PeerJ
https://www.readbyqxmd.com/read/29682031/solitary-fibrous-tumors-of-the-orbit-and-central-nervous-system-a-case-series-analysis
#20
Marisa Brum, Hipólito Nzwalo, Edson Oliveira, Maria Rita Pelejão, Pedro Pereira, João Paulo Farias, José Pimentel
Introduction: Solitary fibrous tumor (SFT) is rarely diagnosed in clinical practice. Since its initial descriptions in the central nervous system (CNS) and the orbits, very few case reports and small case series have expanded their clinical and pathological characterization. We sought to describe a cases series of SFT from a single laboratory of neuropathology belonging to a tertiary university hospital. Methods: Retrospective clinical and histopathological description of eight cases of CNS and orbital SFT diagnosed over a 21-year period of time...
April 2018: Asian Journal of Neurosurgery
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