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https://www.readbyqxmd.com/read/27891609/role-of-trpm7-in-cerebral-ischaemia-and-hypoxia
#1
Hong-Shuo Sun
Transient receptor potential melastatin 7 (TRPM7) channel, a calcium-permeable non-selective divalent cation channel, is broadly expressed in various cells and tissues, including the brain. TRPM7 is thought to be coupled to the metabolic state and regulate calcium homeostasis in the cell. TRPM7 takes part in a wide range of cell biology processes that affect cell growth and proliferation, as well as in embryonic development and skeleton formation. TRPM7 plays a significant role in ischaemic and hypoxic brain injury and neuronal cell death...
November 27, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27818786/trpm7-is-down-regulated-in-both-left-atria-and-left-ventricle-of-ischaemic-cardiomyopathy-patients-and-highly-related-to-changes-in-ventricular-function
#2
Ana Ortega, Esther Roselló-Lletí, Estefanía Tarazón, Carolina Gil-Cayuela, Francisca Lago, Jose-Ramón González-Juanatey, Luis Martinez-Dolz, Manuel Portolés, Miguel Rivera
AIMS: The kinase ion channel transient receptor potential melastatin 7 (TRPM7) is considered a modulator of cardiac fibrosis progression; nevertheless, we lack of studies analysing its role in human ischaemic cardiomyopathy (ICM). Our objective was to analyse the expression of genes encoding cardiac ion channels in human ICM, focusing on the alterations in mRNA levels of TRPM7 and its relationship with changes in the ventricular function. METHODS AND RESULTS: RNA-sequencing was carried out in 13 left ventricular (LV) samples of patients with ICM compared with a control group (n = 10)...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27803760/carvacrol-alleviates-prostate-cancer-cell-proliferation-migration-and-invasion-through-regulation-of-pi3k-akt-and-mapk-signaling-pathways
#3
Yun Luo, Jie-Ying Wu, Min-Hua Lu, Zhi Shi, Ning Na, Jin-Ming Di
TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27754098/os-21-03-effects-of-the-trpm7-kinase-domain-in-vascular-dysfunction-and-cardiac-fibrosis-induced-by-aldosterone-and-salt
#4
Francisco J Rios, Katie Y Hood, A Karvey, Karla B Neves, Panagiota Anyfanti, Ryszard Nosalski, Livia L Camargo Ll, Augusto C Montezano, Rhian M Touyz
OBJECTIVE: TRPM7 is cation channel with intrinsic kinase activity important for cellular Mg homeostasis. We recently showed that TRPM7-kinase plays a role in aldosterone-mediated vascular effects and inflammation. Here we explored the putative role of TRPM7-kinase in cardiac fibrosis and vascular function in aldosterone-induced hypertension in mice. DESIGN AND METHOD: Wild-type (WT) or heterozygote TRPM7-kinase domain (TRPM7+/-) mice were treated with infused aldosterone (600 μg/Kg/day) and NaCl 1% in drinking water (aldo/salt) for 4 weeks...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27693494/bradykinin-promotes-migration-and-invasion-of-hepatocellular-carcinoma-cells-through-trpm7-and-mmp2
#5
Yijie Chen, Yang Yu, Shuya Sun, Zhaotong Wang, Peiqing Liu, Shenglan Liu, Jianmin Jiang
Tumor metastasis is the main reason of death for hepatocellular carcinoma (HCC) patients. Cell migration and invasion are two prerequisites for tumor metastasis, in which TRPM7 and MMPs play an important role. In our study, we found that bradykinin (BK) could upregulate the expression of TRPM7 and dynamically regulate the phosphorylation of non-muscle myosin IIA heavy chain (NMHC-IIA) Ser-1943 in HepG2 cells. The influx of Ca(2+) via TRPM7 was necessary for elevating the activity of m-calpain and μ-calpain...
September 30, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27681336/trpm7-like-channels-are-functionally-expressed-in-oocytes-and-modulate-post-fertilization-embryo-development-in-mouse
#6
Ingrid Carvacho, Goli Ardestani, Hoi Chang Lee, Kaitlyn McGarvey, Rafael A Fissore, Karin Lykke-Hartmann
The Transient Receptor Potential (TRP) channels are a family of cationic ion channels widely distributed in mammalian tissues. In general, the global genetic disruption of individual TRP channels result in phenotypes associated with impairment of a particular tissue and/or organ function. An exception is the genetic ablation of the TRP channel TRPM7, which results in early embryonic lethality. Nevertheless, the function of TRPM7 in oocytes, eggs and pre-implantation embryos remains unknown. Here, we described an outward rectifying non-selective current mediated by a TRP ion channel in immature oocytes (germinal vesicle stage), matured oocytes (metaphase II eggs) and 2-cell stage embryos...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27662662/decreased-trpm7-inhibits-activities-and-induces-apoptosis-of-bladder-cancer-cells-via-erk1-2-pathway
#7
Rui Cao, Zhe Meng, Tongzu Liu, Gang Wang, Guofeng Qian, Tingting Cao, Xinyuan Guan, Hancai Dan, Yu Xiao, Xinghuan Wang
Transient receptor potential melastatin 7 (TRPM7) functions as a Mg2+/Ca2+-permeable channel fused with a kinase domain and regulates various physical processes and diseases. However, its effects on pathogenesis of human bladder cancer (BCa) has not been clarified yet. Our microarray analysis has suggested that calcium signaling pathway is connected with bladder cancer via MAPK pathway. Therefore, we aim to investigate the mechanism of TRPM7 in BCa tumorigenesis by using BCa tissues compared with normal bladder epithelium tissues, as well as using distinct BCa cell lines (EJ, 5637 and T24)...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27651019/the-mechanosensor-of-mesenchymal-stem-cells-mechanosensitive-channel-or-cytoskeleton
#8
E Xiao, Chider Chen, Yi Zhang
Mesenchymal stem cells (MSCs) are multipotent adult stem cells. MSCs and their potential for use in regenerative medicine have been investigated extensively. Recently, the mechanisms by which MSCs detect mechanical stimuli have been described in detail. As in other cell types, both mechanosensitive channels, such as transient receptor potential melastatin 7 (TRPM7), and the cytoskeleton, including actin and actomyosin, have been implicated in mechanosensation in MSCs. This review will focus on discussing the precise role of TRPM7 and the cytoskeleton in mechanosensation in MSCs...
September 20, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27643023/os-21-03-effects-of-the-trpm7-kinase-domain-in-vascular-dysfunction-and-cardiac-fibrosis-induced-by-aldosterone-and-salt
#9
Francisco J Rios, Katie Y Hood, A Karvey, Karla B Neves, Panagiota Anyfanti, Ryszard Nosalski, Livia L Camargo Ll, Augusto C Montezano, Rhian M Touyz
OBJECTIVE: TRPM7 is cation channel with intrinsic kinase activity important for cellular Mg homeostasis. We recently showed that TRPM7-kinase plays a role in aldosterone-mediated vascular effects and inflammation. Here we explored the putative role of TRPM7-kinase in cardiac fibrosis and vascular function in aldosterone-induced hypertension in mice. DESIGN AND METHOD: Wild-type (WT) or heterozygote TRPM7-kinase domain (TRPM7+/-) mice were treated with infused aldosterone (600 μg/Kg/day) and NaCl 1% in drinking water (aldo/salt) for 4 weeks...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27631550/neuroprotective-role-of-microrna-22-in-a-6-hydroxydopamine-induced-cell-model-of-parkinson-s-disease-via-regulation-of-its-target-gene-trpm7
#10
Chao Ping Yang, Zhen Hua Zhang, Li Hua Zhang, Han Chen Rui
Parkinson's disease (PD), the second most prevalent neurodegenerative disorder with only symptomatic treatment available, is characterized by a progressive loss of dopaminergic neurons in the midbrain. Ample evidence indicated that microRNAs (miRs) could regulate post-transcriptional gene expression and neuronal disease. In the present study, we have evaluated the effects and mechanism of miR-22 in PC12 pheochromocytoma cells treated with 6-hydroxydopamine (6-OHDA) to mimic PD. RT-PCR results showed that the expression of miR-22 is downregulated in 6-OHDA-treated PC12 cells, and the overexpression of miR-22 significantly promoted the survival and proliferation of 6-OHDA-induced PC12 cells, whereas miR-22 inhibitor reversed these effects...
September 8, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27629139/trpm7-channel-inhibition-mediates-midazolam-induced-proliferation-loss-in-human-malignant-glioma
#11
Jingkao Chen, Yunling Dou, Xiaoke Zheng, Tiandong Leng, Xiaofang Lu, Ying Ouyang, Huawei Sun, Fan Xing, Jialuo Mai, Jiayu Gu, Bingzheng Lu, Guangmei Yan, Jun Lin, Wenbo Zhu
The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or apoptosis of some cancers, indicating the potential of TRPM7 as an anti-anaplastic target. Here, we identified the characteristic TRPM7 channel currents in human malignant glioma MGR2 cells, which could be blocked by a pharmacologic inhibitor Gd(3+). We mined the clinical sample data from Oncomine Database and found that human malignant glioma tissues expressed higher TRPM7 mRNA than normal brain ones. Importantly, we identified a widely used clinical anesthetic midazolam as a TRPM7 inhibitor...
September 14, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27628598/the-coiled-coil-domain-of-zebrafish-trpm7-regulates-mg%C3%A2-nucleotide-sensitivity
#12
Chad Jansen, Jaya Sahni, Sayuri Suzuki, F David Horgen, Reinhold Penner, Andrea Fleig
TRPM7 is a member of the Transient-Receptor-Potential Melastatin ion channel family. TRPM7 is a unique fusion protein of an ion channel and an α-kinase. Although mammalian TRPM7 is well characterized biophysically and its pivotal role in cancer, ischemia and cardiovascular disease is becoming increasingly evident, the study of TRPM7 in mouse models has been hampered by embryonic lethality of transgenic ablations. In zebrafish, functional loss of TRPM7 (drTRPM7) manifests itself in an array of non-lethal physiological malfunctions...
September 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27614570/aripiprazole-inhibits-polyi-c-induced-microglial-activation-possibly-via-trpm7
#13
Mina Sato-Kasai, Takahiro A Kato, Masahiro Ohgidani, Yoshito Mizoguchi, Noriaki Sagata, Shogo Inamine, Hideki Horikawa, Kohei Hayakawa, Norihiro Shimokawa, Sota Kyuragi, Yoshihiro Seki, Akira Monji, Shigenobu Kanba
Viral infections during fetal and adolescent periods, as well as during the course of schizophrenia itself have been linked to the onset and/or relapse of a psychosis. We previously reported that the unique antipsychotic aripiprazole, a partial D2 agonist, inhibits the release of tumor necrosis factor (TNF)-α from interferon-γ-activated rodent microglial cells. Polyinosinic-polycytidylic acid (polyI:C) has recently been used as a standard model of viral infections, and recent in vitro studies have shown that microglia are activated by polyI:C...
September 7, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27604090/recent-advances-in-oncogenic-roles-of-the-trpm7-chanzyme
#14
Mathieu Gautier, Marianne Perrière, Michael Monet, Alison Vanlaeys, Irina Korichneva, Isabelle Dhennin-Duthille, Halima Ouadid-Ahidouch
Transient Receptor Potential Melastatin-related 7 (TRPM7) is a non-selective cation channel fused with a functional kinase domain. Physiologically, TRPM7 channel is involved in magnesium homeostasis, cell survival and gastrulation. The channel part is responsible for calcium, magnesium, and metal trace entries. Cation current through TRPM7 channel is inhibited by both intracellular magnesium and magnesium complexed with nucleotides. In parallel, the kinase is able to phosphorylate cytoskeleton proteins like myosin chain regulating cell tension and motility...
September 7, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27574117/intersection-of-calorie-restriction-and-magnesium-in-the-suppression-of-genome-destabilizing-rna-dna-hybrids
#15
Karan J Abraham, Janet N Y Chan, Jayesh S Salvi, Brandon Ho, Amanda Hall, Elva Vidya, Ru Guo, Samuel A Killackey, Nancy Liu, Jeffrey E Lee, Grant W Brown, Karim Mekhail
Dietary calorie restriction is a broadly acting intervention that extends the lifespan of various organisms from yeast to mammals. On another front, magnesium (Mg(2+)) is an essential biological metal critical to fundamental cellular processes and is commonly used as both a dietary supplement and treatment for some clinical conditions. If connections exist between calorie restriction and Mg(2+) is unknown. Here, we show that Mg(2+), acting alone or in response to dietary calorie restriction, allows eukaryotic cells to combat genome-destabilizing and lifespan-shortening accumulations of RNA-DNA hybrids, or R-loops...
October 14, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27571347/implant-derived-magnesium-induces-local-neuronal-production-of-cgrp-to-improve-bone-fracture-healing-in-rats
#16
Yifeng Zhang, Jiankun Xu, Ye Chun Ruan, Mei Kuen Yu, Micheal O'Laughlin, Helen Wise, Di Chen, Li Tian, Dufang Shi, Jiali Wang, Sihui Chen, Jian Q Feng, Dick Ho Kiu Chow, Xinhui Xie, Lizhen Zheng, Le Huang, Shuo Huang, Kwoksui Leung, Na Lu, Lan Zhao, Huafang Li, Dewei Zhao, Xia Guo, Kaiming Chan, Frank Witte, Hsiao Chang Chan, Yufeng Zheng, Ling Qin
Orthopedic implants containing biodegradable magnesium have been used for fracture repair with considerable efficacy; however, the underlying mechanisms by which these implants improve fracture healing remain elusive. Here we show the formation of abundant new bone at peripheral cortical sites after intramedullary implantation of a pin containing ultrapure magnesium into the intact distal femur in rats. This response was accompanied by substantial increases of neuronal calcitonin gene-related polypeptide-α (CGRP) in both the peripheral cortex of the femur and the ipsilateral dorsal root ganglia (DRG)...
October 2016: Nature Medicine
https://www.readbyqxmd.com/read/27555537/trpm7-functions-in-non-neuronal-and-neuronal-systems-perspectives-on-its-role-in-the-adult-brain
#17
Nashat Abumaria, Wei Li, Yuqiang Liu
Transient receptor potential melastatin-like 7 (TRPM7) has a unique dual protein structure. It is an ion channel that has biophysical characteristics enabling divalent cations transport and a kinase domain involved in molecular events starting from modulating signaling pathways to inducing chromatin remodeling. Over the past 15 years, significant progress in the molecular and functional characterization of TRPM7 has been made in peripheral tissue and/or cell lines. TRPM7 appears to be involved in a plethora of physiological and pathological processes including embryonic development, organogenesis, cell proliferation and survival, and cell death following certain triggers...
August 20, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27513275/the-effects-of-bupivacaine-combined-with-different-adjuvants-on-block-onset-and-duration-and-on-ion-channel-expressions-scn9a-trpm-in-sciatic-nerve-block-in-rats
#18
Nurgül Dolu, Levent Şahin, Davut Sinan Kaplan, Tuncer Demir, Hasan Şimşek, Mehrican Şahin, Beyhan Cengiz
BACKGROUND/AIM: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. MATERIALS AND METHODS: Rats were divided into five groups: Group S (sham), saline solution; Group B, bupivacaine; Group BD, bupivacaine + dexmedetomidine; Group BC, bupivacaine + clonidine; and Group BE, bupivacaine + epinephrine...
April 19, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27466368/aldosterone-upregulates-transient-receptor-potential-melastatin-7-trpm7
#19
William C Valinsky, Anna Jolly, Perrine Miquel, Rhian M Touyz, Alvin Shrier
Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed Mg(2+)-permeable ion channel fused to a C-terminal α-kinase domain. Recently, aldosterone was shown to increase intracellular Mg(2+) levels and alter inflammatory signaling in TRPM7-expressing HEK293 cells. This study was undertaken to assess whether these effects were related to an aldosterone-mediated increase of TRPM7 current and/or plasma membrane localization. Using HEK293 cells stably expressing WT-TRPM7, we found that 18-h application of aldosterone significantly increased TRPM7 current and TRPM7 plasma membrane protein expression by 48% and 34%, respectively...
September 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27464700/expression-of-transient-receptor-potential-channels-in-the-purified-human-pancreatic-%C3%AE-cells
#20
Francesco Marabita, Md Shahidul Islam
OBJECTIVE: Members of the transient receptor potential (TRP) channels are involved in mediating the electrical excitability and stimulus-secretion coupling in the pancreatic β-cells. The expression and the relative abundance of different TRP channels in the human β-cells are unknown. The objective of this study was to examine the expression of the TRP channels and their relative abundance in the human β-cell. METHODS: RNA sequencing data obtained from human islets, fluorescence-activated cell sorting-purified human β-cell and human pancreatic acinar cells were analyzed...
July 25, 2016: Pancreas
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