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https://www.readbyqxmd.com/read/29917255/an-avatar-based-education-application-to-improve-patients-knowledge-of-and-response-to-heart-attack-symptoms-a-pragmatic-randomized-controlled-trial-protocol
#1
Jintana Tongpeth, Huiyun Du, Robyn Clark
AIM: To evaluate the effectiveness of an interactive, avatar based education application to improve knowledge of and response to heart attack symptoms in people who are at risk of a heart attack. BACKGROUND: Poor knowledge of heart attack symptoms is recognised as a significant barrier to timely medical treatment. Numerous studies have demonstrated that technology can assist in patient education to improve knowledge and self-care. DESIGN: A single-center, non-blinded, two parallel groups, pragmatic randomized controlled trial...
June 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29917118/considering-systemic-barriers-to-treating-tobacco-use-in-clinical-settings-in-the-united-states
#2
Alana M Rojewski, Steffani R Bailey, Steven L Bernstein, Nina A Cooperman, Ellen R Gritz, Maher A Karam-Hage, Megan E Piper, Nancy A Rigotti, Graham W Warren
The Comorbidity Workgroup of the Tobacco Treatment Research Network, within the Society for Research on Nicotine and Tobacco, previously highlighted the need to provide tobacco treatment to patients diagnosed with comorbid physical and mental health conditions. Yet, systemic barriers in the United States healthcare system prevent many patients who present for medical treatment from getting the evidence-based tobacco treatment that they need. The identified barriers include insufficient training in the epidemiologic impact of tobacco use, related disorders, and pharmacological and behavioral treatment approaches; misunderstanding among clinicians about the effectiveness of tobacco treatment; lack of therapeutic support from clinical staff; insufficient use of health information technology to improve tobacco use identification and treatment; and limited time and reimbursement for clinicians to provide treatment...
June 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29916597/preliminary-report-on-left-ventricular-assist-devices-are-patients-and-caregivers-psychosocial-needs-adequately-addressed
#3
Silvia Rossi Ferrario, Gianluigi Balestroni, Chiara Gattoni, Giovanna Omarini, Pierangela Omarini, Paola Cerutti, Massimo Pistono
OBJECTIVES: Patients implanted with a Left Ventricular Assist Device (LVAD) constitute a new population of chronic heart failure (HF) patients requiring continuous medical support and representing heavy costs - both direct and indirect - for the healthcare system. If there is consensus about the increased survival, the psychosocial outcomes, in terms of psychological wellbeing, behavioral and social functioning of both patients and caregivers, are still unclear. Overall, it is not clear if local health and social services are equipped to support them in their needs...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916428/prophylactic-hydration-to-protect-renal-function-from-intravascular-iodinated-contrast-material
#4
Akshay D Baheti, Bhavin Jankharia
Nijssen EC, Rennenberg RJ, Nelemans PJ, Essers BA, Janssen MM, Vermeeren MA, van Ommen V, Wildberger JE. (Departments of Radiology and Nuclear Medicine, Internal Medicine, Epidemiology, Clinical Epidemiology and Medical Technology Assessment, and Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.) Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): A prospective, randomised, phase 3, controlled, open-label, non-inferiority trial...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916292/process-of-medical-simulator-development-an-approach-based-on-personal-experience
#5
Dinker R Pai, Chau P N Minh, Morten B S Svendsen
With increasing demand for simulators from the healthcare community and increasingly sophisticated technology being used in the manufacture of medical simulators, the manufacture of healthcare simulators has become a multifaceted undertaking. Based on our experience in the field and our diverse backgrounds, we explore the processes and issues related to the development of these simulators and suggest ways for the developing teams to collaborate and coordinate with each other to achieve a successful outcome.
June 19, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29915997/synthetic-biology-advances-and-applications-in-the-biotechnology-industry-a-perspective
#6
Leonard Katz, Yvonne Y Chen, Ramon Gonzalez, Todd C Peterson, Huimin Zhao, Richard H Baltz
Synthetic biology is a logical extension of what has been called recombinant DNA (rDNA) technology or genetic engineering since the 1970s. As rDNA technology has been the driver for the development of a thriving biotechnology industry today, starting with the commercialization of biosynthetic human insulin in the early 1980s, synthetic biology has the potential to take the industry to new heights in the coming years. Synthetic biology advances have been driven by dramatic cost reductions in DNA sequencing and DNA synthesis; by the development of sophisticated tools for genome editing, such as CRISPR/Cas9; and by advances in informatics, computational tools, and infrastructure to facilitate and scale analysis and design...
June 18, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29915933/an-electronic-dashboard-to-monitor-patient-flow-at-the-johns-hopkins-hospital-communication-of-key-performance-indicators-using-the-donabedian-model
#7
Diego A Martinez, Erin M Kane, Mehdi Jalalpour, James Scheulen, Hetal Rupani, Rohit Toteja, Charles Barbara, Bree Bush, Scott R Levin
Efforts to monitoring and managing hospital capacity depend on the ability to extract relevant time-stamped data from electronic medical records and other information technologies. However, the various characterizations of patient flow, cohort decisions, sub-processes, and the diverse stakeholders requiring data visibility create further overlying complexity. We use the Donabedian model to prioritize patient flow metrics and build an electronic dashboard for enabling communication. Ten metrics were identified as key indicators including outcome (length of stay, 30-day readmission, operating room exit delays, capacity-related diversions), process (timely inpatient unit discharge, emergency department disposition), and structural metrics (occupancy, discharge volume, boarding, bed assignation duration)...
June 18, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29915644/right-ventricular-dysplasia-management-and-treatment-in-light-of-current-evidence
#8
REVIEW
Amr Idris, Syed Raza Shah, Ki Park
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare cardiovascular disease that predisposes to ventricular arrhythmias potentially leading to sudden cardiac death (SCD). ARVC varies considerably with multiple clinical presentations, ranging from no symptoms to cardiac arrhythmias to SCD. ARVC prevalence is not well known, but the estimated prevalence in the general population is 1:5000. Diagnosis of ARVC can be made by using the Revised European Society of Cardiology criteria for ARVC that includes ventricular structural and functional changes, ECG abnormalities, arrhythmias, family and genetic factors...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915349/development-of-a-computer-aided-tool-for-the-pattern-recognition-of-facial-features-in-diagnosing-turner-syndrome-comparison-of-diagnostic-accuracy-with-clinical-workers
#9
Shi Chen, Zhou-Xian Pan, Hui-Juan Zhu, Qing Wang, Ji-Jiang Yang, Yi Lei, Jian-Qiang Li, Hui Pan
Technologies applied for the recognition of facial features in diagnosing certain disorders seem to be promising in reducing the medical burden and improve the efficiency. This pilot study aimed to develop a computer-assisted tool for the pattern recognition of facial features for diagnosing Turner syndrome (TS). Photographs of 54 patients with TS and 158 female controls were collected from July 2016 to May 2017. Finally, photographs of 32 patients with TS and 96 age-matched controls were included in the study that were further divided equally into training and testing groups...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914449/hiv-rapid-testing-in-community-and-outreach-sites-results-of-a-nationwide-demonstration-project-in-italy
#10
Paola Scognamiglio, Giacomina Chiaradia, Marta Giovanetti, Emidio Albertini, Antonella Camposeragna, Massimo Farinella, Daniela Lorenzetti, Massimo Oldrini, Laura Rancilio, Anna Caraglia, Francesco Paolo Maraglino, Giuseppe Ippolito, Enrico Girardi
BACKGROUND: Globally the access to HIV testing has greatly increased over the past 30 years. Nonetheless, a high proportion of people living with HIV remains undiagnosed, even in resource rich countries. To increase the proportion of people aware of their HIV serostatus and their access to medical care, several strategies have been proposed including HIV rapid test programs offered outside health facilities. The aim of this project was to evaluate the feasibility and efficacy of the HIV rapid testing offered in community and outreach settings in Italy...
June 18, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29914357/algorithms-designed-for-compressed-gene-data-transformation-among-gene-banks-with-different-references
#11
Qiuming Luo, Chao Guo, Yi Jun Zhang, Ye Cai, Gang Liu
BACKGROUND: With the reduction of gene sequencing cost and demand for emerging technologies such as precision medical treatment and deep learning in genome, it is an era of gene data outbreaks today. How to store, transmit and analyze these data has become a hotspot in the current research. Now the compression algorithm based on reference is widely used due to its high compression ratio. There exists a big problem that the data from different gene banks can't merge directly and share information efficiently, because these data are usually compressed with different references...
June 18, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#12
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29912733/a-paradigm-shift-toward-terminally-sterilized-devices
#13
Aakash Agarwal, Adam MacMillan, Vijay Goel, Anand K Agarwal, Chris Karas
Given the complexity of the sterilization process, and the risk involved in absence of strict adherence to the protocol described by the medical device manufacturers, terminally sterilized devices are emerging and being promoted in the field of medical practices. The characteristics associated with conventional reprocessing are demanding logistics, costs of delay, operations and adverse events, and unacceptable liability. Demanding logistics were a result of decoupled staff between the operating room and sterilize processing department, understaffed and high-volume processing with an additional burden due to inventory management and inefficient training...
June 15, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29911696/plasmid-dna-vaccines-where-are-we-now
#14
F Ghaffarifar
DNA vaccines are considered as third-generation vaccines. The recombinant DNA technology plays an important role in the production of DNA vaccines. These vaccines are intended to increase DNA insertion and translation in the cell, activate CD4+ T cells, and enhance cytotoxic T-lymphocyte induction and antibody production. DNA vaccines are safe with few side effects in humans and animals. Their immunogenicity can be improved by the use of suitable adjuvants and proper delivery systems. In recent years, strategies have been developed to increase the efficacy of DNA vaccines through electroporation, as well as the use of cytokines, genetically engineered vectors, liposomes, and micro- or nanoparticles...
May 2018: Drugs of Today
https://www.readbyqxmd.com/read/29910957/perspectives-on-human-regeneration
#15
James F Stark
Regeneration is a concept that has fascinated humans for centuries. Whether we have been trying to bring things back to life, extract additional resources from the world, or remodel our living spaces-domestic and urban-it is often presented as an unproblematic force for good. But what exactly does it mean to regenerate a body, mind or space? This paper, which introduces a collection of contributions on the theme of human regeneration, explores the limits and possibilities of regeneration as a conceptual tool for understanding the biological realm...
June 12, 2018: Palgrave Communications
https://www.readbyqxmd.com/read/29910692/measuring-the-impact-of-the-home-health-nursing-shortage-on-family-caregivers-of-children-receiving-palliative-care
#16
Meaghann S Weaver, Brittany Wichman, Sue Bace, Denice Schroeder, Catherine Vail, Chris Wichman, Andrew Macfadyen
The national nursing shortage translates into a gap in home nursing care available to children with complex, chronic medical conditions and their family caregivers receiving palliative care consultations. A total of 38 home health nursing surveys were completed by families receiving pediatric palliative care consultation services at a freestanding children's hospital in the Midwest. The gap in the average number of nursing hours allotted versus received was 40 h/wk per family, primarily during evening hours...
June 2018: Journal of Hospice and Palliative Nursing: JHPN
https://www.readbyqxmd.com/read/29909867/selection-of-and-evidentiary-considerations-for-wearable-devices-and-their-measurements-for-use-in-regulatory-decision-making-recommendations-from-the-epro-consortium
#17
Bill Byrom, Chris Watson, Helen Doll, Stephen Joel Coons, Sonya Eremenco, Rachel Ballinger, Marie Mc Carthy, Mabel Crescioni, Paul O'Donohoe, Cindy Howry
BACKGROUND: Wearable devices offer huge potential to collect rich sources of data to provide insights into the effects of treatment interventions. Despite this, at the time of writing this report, limited regulatory guidance on the use of wearables in clinical trial programs has been published. OBJECTIVES: To present recommendations from the Critical Path Institute's Electronic Patient-Reported Outcome Consortium regarding the selection and evaluation of wearable devices and their measurements for use in regulatory trials and to support labeling claims...
June 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29909792/health-technology-assessment-methods-guidelines-for-medical-devices-how-can-we-address-the-gaps-the-international-federation-of-medical-and-biological-engineering-perspective
#18
Julie Polisena, Rossana Castaldo, Oriana Ciani, Carlo Federici, Simone Borsci, Matteo Ritrovato, Daniel Clark, Leandro Pecchia
OBJECTIVES: Current health technology assessment (HTA) methods guidelines for medical devices may benefit from contributions by biomedical and clinical engineers. Our study aims to: (i) review and identify gaps in the current HTA guidelines on medical devices, (ii) propose recommendations to optimize the impact of HTA for medical devices, and (iii) reach a consensus among biomedical engineers on these recommendations. METHODS: A gray literature search of HTA agency Web sites for assessment methods guidelines on devices was conducted...
June 18, 2018: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29909476/the-use-of-ehealth-to-promote-physical-activity-in-cancer-survivors-a-systematic-review
#19
Ciarán Haberlin, Tom O'Dwyer, David Mockler, Jonathan Moran, Dearbhaile M O'Donnell, Julie Broderick
PURPOSE: Achieving adequate levels of physical activity (PA) and avoiding sedentary behaviour are particularly important in cancer survivors. eHealth, which includes, but is not limited to, the delivery of health information through Internet and mobile technologies, is an emerging concept in healthcare which may present opportunities to improve PA in cancer survivors. The aim of this systematic review was to explore the effects of eHealth in the promotion of PA among cancer survivors...
June 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29909238/autophagy-as-an-emerging-target-in-cardiorenal-metabolic-disease-from-pathophysiology-to-management
#20
REVIEW
Yingmei Zhang, Adam T Whaley-Connell, James R Sowers, Jun Ren
Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation...
June 15, 2018: Pharmacology & Therapeutics
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