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Radical prostatectomy

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https://www.readbyqxmd.com/read/28222486/accuracy-of-real-time-magnetic-resonance-imaging-transrectal-ultrasound-fusion-image-guided-transperineal-target-biopsy-with-needle-tracking-with-a-mechanical-position-encoded-stepper-in-detecting-significant-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#1
Sunao Shoji, Shinichiro Hiraiwa, Takahiro Ogawa, Masayoshi Kawakami, Mayura Nakano, Kazunobu Hashida, Yoshinobu Sato, Terumitsu Hasebe, Toyoaki Uchida, Takuma Tajiri
OBJECTIVE: To evaluate the accuracy of real-time elastic fusion image-guided transperineal prostate biopsy with needle tracking involving a mechanical position-encoded stepper in detecting clinically significant prostate cancer for biopsy-naïve men. METHODS: We prospectively recruited patients with serum prostate-specific antigen levels of 4.0-20 ng/mL and suspicious of prostate cancer on multiparametric magnetic resonance imaging. They underwent targeted biopsies for cancer-suspicious lesions and 12-core systematic biopsies...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28222423/introduction-of-an-enhanced-recovery-after-surgery-protocol-for-robot-assisted-laparoscopic-radical-prostatectomy
#2
Motohiko Sugi, Tadashi Matsuda, Takashi Yoshida, Hisanori Taniguchi, Takao Mishima, Masaaki Yanishi, Yoshihiro Komai, Kaneki Yasuda, Hidefumi Kinoshita, Kenji Yoshida, Masato Watanabe
INTRODUCTION: No studies have shown whether the enhanced recovery after surgery (ERAS) protocol is superior to the conventional protocol after robot-assisted laparoscopic radical prostatectomy (RALP). We compared intestinal function and perioperative parameters of patients with prostate cancer after the ERAS and conventional protocols to determine the superior protocol for recovery of intestinal function. MATERIAL AND METHODS: A retrospective analysis of 198 consecutive patients who underwent RALP between August 2013 and June 2015 was conducted...
February 17, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28222069/patients-perceptions-of-the-negative-effects-following-different-prostate-cancer-treatments-and-the-impact-on-psychological-well-being-a-nationwide-survey
#3
Ulla-Sisko Lehto, Heli Tenhola, Kimmo Taari, Arpo Aromaa
BACKGROUND: Although the prognosis of localised prostate cancer is good, the negative effects of prostate cancer treatment often impair patient quality of life. A growing number of men experience these negative effects over a longer time because of the increased incidence of and prolonged survival in prostate cancer, and the ageing of the population. Only a few studies have investigated the adverse effects of different prostate cancer treatments using large population-based samples. METHODS: We conducted a nationwide survey (n=1239) to collect detailed information regarding the negative effects (i...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28220805/meta-analysis-of-metabolic-syndrome-and-prostate-cancer
#4
REVIEW
M Gacci, G I Russo, C De Nunzio, A Sebastianelli, M Salvi, L Vignozzi, A Tubaro, G Morgia, S Serni
BACKGROUND: Metabolic syndrome (MetS) and prostate cancer (PCa) are highly prevalent conditions worldwide. Current evidence suggests the emerging hypothesis that MetS could play a role in the development and progression of several neoplasms. The aims of this study are to evaluate the impact of MetS and MetS factors on PCa incidence, on the risk of high-grade PCa and to analyze the role of MetS and single MetS components on the development of aggressive PCa features. METHODS: A systematic literature search and analysis on PubMed, EMBASE, Cochrane and Academic One File databases until September 2015 was performed by 2 independent reviewers to evaluate the associations between MetS and PCa incidence, and between MetS and high-grade PCa incidence (bioptical Gleason Score⩾8, Prognostic Group 4-5 according to the novel prostate cancer grading system)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28220652/etiology-and-management-of-earlier-versus-later-biochemical-recurrence-following-retropubic-radical-prostatectomy
#5
Elton Llukani, Herbert Lepor
Approximately 100,000 radical prostatectomies (RP) are performed annually in the US with the intent to cure clinically localized prostate cancer. Oncological control following RP is assessed by monitoring serum PSA levels. By consensus, a PSA exceeding 0.2 ng/mL is considered the threshold for a biochemical recurrence (BCR) following RP (3). BCR often predates radiographic and clinical evidence of disease recurrence by many years (4-6). This article is protected by copyright. All rights reserved.
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28217451/erectile-dysfunction-masculinity-and-psychosocial-outcomes-a-review-of-the-experiences-of-men-after-prostate-cancer-treatment
#6
REVIEW
Suzanne K Chambers, Eric Chung, Gary Wittert, Melissa K Hyde
Prostate cancer (PC) treatment side-effects such as erectile dysfunction (ED) can impact men's quality of life (QoL), psychosocial and psycho-sexual adjustment. Masculinity (i.e., men's identity or sense of themselves as being a man) may also be linked to how men respond to PC treatment and ED however the exact nature of this link is unclear. This review aims to provide a snapshot of the current state of evidence regarding ED, masculinity and psychosocial impacts after PC treatment. Three databases (Medline/PsycINFO, CINHAL, and EMBASE) were searched January 1st 1980 to January 31st 2016...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28217445/the-controversy-surrounding-penile-rehabilitation-after-radical-prostatectomy
#7
REVIEW
Jonathan Clavell-Hernández, Run Wang
Radical prostatectomy (RP) techniques have been refined in the last few decades. Despite nerve-sparing surgery, erectile dysfunction (ED) still seems to be affecting more than half of patients undergoing RP. Penile rehabilitation consists of understanding the mechanisms that affect erectile function (EF) and utilizing pharmacologic agents, devices or interventions to promote male sexual function before and after any insult to the penile erectile physiologic axis. There currently is a limited amount of clinical trials that assess treatments with the goal of recovering post-prostatectomy EF...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28216940/epididymal-metastasis-from-prostate-adenocarcinoma-an-unusual-and-challenging-diagnosis-suspected-in-gallium-68-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-and-histologically-confirmed
#8
Sofia Santos-Lopes, João Lobo, Rui Henrique, Jorge Oliveira
A few cases of prostate adenocarcinoma (PCa) metastases to the epididymis have been documented in literature. We report a case of a 69-year-old man with a left epididymal metastasis, 6 years after radical prostatectomy and adjuvant radiation therapy for PCa. Although he developed biochemical recurrence, only gallium-68 prostate-specific membrane antigen-positron emission tomography/computed tomography revealed high uptake in the left testis and retrovesical space. An unrecognized painless firm nodule was palpable on the left epididymis...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216329/oncological-and-functional-outcomes-after-radical-prostatectomy-for-high-or-very-high-risk-prostate-cancer-european-validation-of-the-current-nccn-guideline
#9
Raisa S Pompe, Pierre I Karakiewicz, Zhe Tian, Philipp Mandel, Thomas Steuber, Thorsten Schlomm, Georg Salomon, Markus Graefen, Hartwig Huland, Derya Tilki
PURPOSE: To validate the current NCCN-classification of very high-risk (VHR) patients and compare the pathological, functional and oncological outcomes between surgically treated high- (HR) and VHR patients. MATERIALS & METHODS: We retrospectively analyzed 4041 patients stratified into high- or VHR who underwent RP between 1992-2016. Kaplan-Meier as well as multivariable logistic and Cox regression analyses compared outcomes between the two groups. RESULTS: After RP, the rate of adverse pathological features was higher in 1369 VHR vs...
February 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28216327/combined-whole-body-and-multi-parametric-prostate-mri-as-a-single-step-approach-for-the-simultaneous-assessment-of-local-recurrence-and-metastatic-disease-after-radical-prostatectomy
#10
Nicola L Robertson, Evis Sala, Matthias Benz, Jonathan Landa, Peter Scardino, Howard I Scher, Hedvig Hricak, Hebert A Vargas
PURPOSE: To report our initial experience using "whole body and dedicated prostate (WB+P)" MRI as a single exam for the assessment of local recurrence and metastatic disease in patients with suspected recurrent prostate cancer (PCa) after radical prostatectomy (RP). MATERIALS AND METHODS: IRB-approved retrospective single-center study. 76 consecutive patients with clinically suspected recurrent PCa following RP underwent combined WB+P-MRI in a single session (10/2014-01/2016)...
February 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28216277/comparison-of-oncologic-outcomes-and-complications-according-to-surgical-approach-to-radical-prostatectomy-special-focus-on-the-perineal-approach
#11
Wan Song, Joon Hyung Park, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi
INTRODUCTION: The objective of the study was to compare oncologic outcomes and complications in patients with prostate cancer who underwent radical perineal prostatectomy (RPP), radical retropubic prostatectomy (RRP), laparoscopic radical prostatectomy (LRP), or robotic-assisted radical prostatectomy (RARP). MATERIALS AND METHODS: We retrospectively reviewed 2617 patients who underwent RPP (n = 673), RRP (n = 396), LRP (n = 223), or RARP (n = 1325) between 1995 and 2013...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28214571/encountering-dropped-gallstones-during-robotic-assisted-laparoscopic-radical-prostatectomy
#12
Lisa Brubaker, Michael Allgaeuer, Baris Turkbey, Peter Pinto, Abhinav Sidana
We describe a case of an unusual finding during robotic-assisted laparoscopic radical prostatectomy and bilateral pelvic lymphadenectomy in a 66-year-old male with Stage IIb (T2c, N0, M0) prostate adenocarcinoma. During the operation, intraperitoneal examination of the rectovesical pouch revealed calcifications and stones which were subsequently identified as gallstones. While these stones were not noted initially on this patient's preoperative multiparametric MRI (mpMRI), a retrospective review demonstrated hypointense foci in the rectovesical pouch...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28213801/efficacy-of-a-neoadjuvant-gonadotropin-releasing-hormone-antagonist-plus-low-dose-estramustine-phosphate-in-high-risk-prostate-cancer-a-single-center-study
#13
Kazuhisa Hagiwara, Takuya Koie, Chikara Ohyama, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Yuki Tobisawa, Tohru Yoneyama
PURPOSE: The optimal treatment for high-risk prostate cancer (Pca) remains to be established. We previously reported favorable biochemical recurrence-free survival (BRFS) for high-risk Pca patients treated with neoadjuvant therapy comprising a luteinizing hormone-releasing hormone agonist plus low-dose estramustine (LHRH + EMP) prior to radical prostatectomy (RP). In the present study, we evaluated the efficacy of neoadjuvant therapy comprising a gonadotropin-releasing hormone antagonist plus low-dose estramustine phosphate (GnRH + EMP) in patients with high-risk Pca...
February 17, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28208517/re-pathological-analysis-of-the-prostatic-anterior-fat-pad-at-radical-prostatectomy-insights-from-a-prospective-series
#14
Samir S Taneja
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28205153/sociodemographic-disparities-in-cure-intended-treatment-in-localized-prostate-cancer
#15
Jude K A des Bordes, David S Lopez, Michael D Swartz, Robert J Volk
PURPOSE: Disparities in prostate cancer (PCa) morbidity and mortality occur across various populations. We investigated the sociodemographic correlates of treatment and disparities in the application of cure-intended (i.e., radical prostatectomy [RP], radiation therapy [RT]) treatment strategies in localized PCa among Texas residents diagnosed with PCa. METHODS: We analyzed data from the Texas Cancer Registry on men diagnosed with stage T1 or T2 PCa between 2004 and 2009...
February 15, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28202357/variations-in-the-arterial-blood-supply-to-the-penis-and-the-accessory-pudendal-artery-a-meta-analysis-and-review-of-its-implications-in-radical-prostatectomy
#16
Brandon Michael Henry, Przemysław A Pękala, Jens Vikse, Beatrice Sanna, Bendik Skinningsrud, Karolina Saganiak, Jerzy A Walocha, Krzysztof A Tomaszewski
PURPOSE: The aim of this meta-analysis was to analyze the available literature and provide comprehensive data on the prevalence and variations of accessory pudendal artery (APA) and the three types of penile blood supply (Type 1 - internal pudendal artery (IPA) only, Type 2 - IPA and APA), Type 3 - APA only) MATERIALS AND METHODS: We conducted an extensive search of the major databases and identified 23 studies (4,945 patients) suitable for inclusion in this meta-analysis. Studies eligible for inclusion included cadaveric, imaging or intraoperative studies...
February 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28197033/biochemical-failure-after-radical-prostatectomy-in-intermediate-risk-group-men-increases-with-the-number-of-risk-factors
#17
Nobuki Furubayashi, Takahito Negishi, Hidenori Iwai, Kei Nagase, Kenichi Taguchi, Mototsugu Shimokawa, Motonobu Nakamura
INTRODUCTION: We aimed to determine whether the number and type of risk factors are associated with biochemical recurrence-free survival after radical prostatectomy in men with D'Amico intermediate-risk prostate cancer. MATERIALS AND METHODS: Between August 1998 and May 2013, 481 Japanese patients underwent antegrade radical prostatectomy. The relationships between the rate of PSA failure after radical prostatectomy and the number and type of risk factors were examined in the intermediate-risk group...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28196367/clinical-factors-predicting-tumour-upgrading-in-patients-under-active-surveillance-and-elected-to-active-treatment-after-disease-reclassification-or-progression
#18
Antonio Benito Porcaro, Francesca Cavicchioli, Nicolò De Luyk, Daniele Mattevi, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Davide Inverardi, Giovanni Cacciamani, Davide De Marchi, Matteo Balzarro, Maria A Cerruto, Matteo Brunelli, Giovanni Novella, Salvatore Siracusano, Walter Artibani
OBJECTIVES: To evaluate clinical factors associated with tumour upgrading (UPG) in low-intermediate risk patients who progressed while under active surveillance (AS) and underwent delayed radical prostatectomy. MATERIAL AND METHODS: The evaluated factors included prostate specific antigen (PSA), prostate volume, PSA density and number of biopsy positive cores (BPC). Multivariate logistic regression by the forward step Wald procedure was used. RESULTS: The study evaluated 24 patients who had UPG in 13 cases (54...
February 14, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28193700/the-nuclear-transport-receptor-importin-11-is-a-tumor-suppressor-that-maintains-pten-protein
#19
Muhan Chen, Dawid G Nowak, Navneet Narula, Brian Robinson, Kaitlin Watrud, Alexandra Ambrico, Tali M Herzka, Martha E Zeeman, Matthias Minderer, Wu Zheng, Saya H Ebbesen, Kendra S Plafker, Carlos Stahlhut, Victoria M Y Wang, Lorna Wills, Abu Nasar, Mireia Castillo-Martin, Carlos Cordon-Cardo, John E Wilkinson, Scott Powers, Raffaella Sordella, Nasser K Altorki, Vivek Mittal, Brendon M Stiles, Scott M Plafker, Lloyd C Trotman
Phosphatase and tensin homologue (PTEN) protein levels are critical for tumor suppression. However, the search for a recurrent cancer-associated gene alteration that causes PTEN degradation has remained futile. In this study, we show that Importin-11 (Ipo11) is a transport receptor for PTEN that is required to physically separate PTEN from elements of the PTEN degradation machinery. Mechanistically, we find that the E2 ubiquitin-conjugating enzyme and IPO11 cargo, UBE2E1, are limiting factors for PTEN degradation...
February 13, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28190749/role-of-radical-prostatectomy-in-metastatic-prostate-cancer-a-review
#20
REVIEW
Michael J Metcalfe, Marc C Smaldone, Daniel W Lin, Ana M Aparicio, Brian F Chapin
CONTEXT: Recent demonstration of efficacy with the use of chemohormonal therapy for men with metastatic prostate cancer (mPCa) has expanded the therapeutic options for these patients. Furthermore, multimodal therapy to treat systemic disease in the context of locoregional control has gained increasing interest. Concomitantly, the role of radical prostatectomy (RP) in multimodal treatment for locally advanced prostate cancer is expanding. As a result, there is interest in investigating the potential benefit of cytoreductive RP in mPCa...
February 9, 2017: Urologic Oncology
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