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Radical prostatectomy

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https://www.readbyqxmd.com/read/28806263/18f-dcfbc-prostate-specific-membrane-antigen-targeted-pet-ct-imaging-in-localized-prostate-cancer-correlation-with-multiparametric-mri-and-histopathology
#1
Baris Turkbey, Esther Mena, Liza Lindenberg, Stephen Adler, Sandra Bednarova, Rose Berman, Anita T Ton, Yolanda McKinney, Philip Eclarinal, Craig Hill, George Afari, Sibaprasad Bhattacharyya, Ronnie C Mease, Maria J Merino, Paula M Jacobs, Bradford J Wood, Peter A Pinto, Martin G Pomper, Peter L Choyke
PURPOSE: To assess the ability of (N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-F-fluorobenzyl-L-cysteine) (F-DCFBC), a prostate-specific membrane antigen-targeted PET agent, to detect localized prostate cancer lesions in correlation with multiparametric MRI (mpMRI) and histopathology. METHODS: This Health Insurance Portability and Accountability Act of 1996-compliant, prospective, institutional review board-approved study included 13 evaluable patients with localized prostate cancer (median age, 62...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806117/postdiagnosis-statin-use-and-mortality-in-danish-patients-with-prostate-cancer
#2
Signe Benzon Larsen, Christian Dehlendorff, Charlotte Skriver, Susanne Oksbjerg Dalton, Christina Gade Jespersen, Michael Borre, Klaus Brasso, Mette Nørgaard, Christoffer Johansen, Henrik Toft Sørensen, Jesper Hallas, Søren Friis
Purpose Increasing evidence indicates that statin use may reduce mortality from prostate cancer. In this work, we examined whether postdiagnosis statin use was associated with reduced cancer-specific mortality or all-cause mortality among patients with prostate cancer in Denmark. Material and Methods From nationwide Danish registries, we identified all patients with incident prostate adenocarcinoma from 1998 to 2011 and retrieved data on tumor and patient characteristics, drug use, and primary treatment. We defined postdiagnosis use (two or more prescriptions) of statins as a time-varying covariate with 1-year lag...
August 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28805295/multi-parametric-magnetic-resonance-imaging-mpmri-identifies-significant-apical-prostate-cancers
#3
Alexander P Kenigsberg, Tsutomu Tamada, Andrew B Rosenkrantz, Elton Llukani, Fang-Ming Deng, Jonathan Melamed, Ming Zhou, Herbert Lepor
OBJECTIVE: To determine if multiparametric MRI (mpMRI) identifies significant apical disease, thereby informing decisions regarding preservation of the membranous urethra. MATERIALS AND METHODS: Men undergoing radical prostatectomy between January 2012 and June 2016 who underwent a 12-core transrectal-ultrasound guided systematic biopsy, preoperative 3-T MRI, and sectioning of the prostate specimen with tumor foci mapping were extracted from a single surgeon's prospective longitudinal outcomes database...
August 14, 2017: BJU International
https://www.readbyqxmd.com/read/28805047/outcomes-of-post-prostatectomy-radiotherapy-at-a-regional-cancer-centre
#4
Luke Nicholls, Amber Winter, Ashley Harwood, Ashley Plank, Preeti Bagga, Winnie Wong, Eric Khoo
INTRODUCTION: To investigate the efficacy and toxicity of radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer at Radiation Oncology Centres, Toowoomba. METHODS: The electronic medical records of 130 consecutive patients with histologically proven prostate adenocarcinoma who underwent post-prostatectomy RT between January 2008 and December 2014 were analysed. Primary endpoint was Biochemical Recurrence (BCR) after RT. BCR was defined by PSA > 0...
August 14, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28803034/variations-in-the-costs-of-radical-cystectomy-for-bladder-cancer-in-the-usa
#5
Jeffrey J Leow, Alexander P Cole, Thomas Seisen, Joaquim Bellmunt, Matthew Mossanen, Mani Menon, Mark A Preston, Toni K Choueiri, Adam S Kibel, Benjamin I Chung, Maxine Sun, Steven L Chang, Quoc-Dien Trinh
BACKGROUND: Radical cystectomy (RC) for muscle-invasive bladder cancer (BCa) has potential for serious complications, prolonged length of stay and readmissions-all of which may increase costs. Although variations in outcomes are well described, less is known about determinants driving variation in costs. OBJECTIVE: To assess surgeon- and hospital-level variations in costs and predictors of high- and low-cost RC. DESIGN, SETTING, AND PARTICIPANTS: Cohort study of 23 173 patients who underwent RC for BCa in 208 hospitals in the USA from 2003 to 2015 in the Premier Healthcare Database...
August 9, 2017: European Urology
https://www.readbyqxmd.com/read/28801241/trends-in-radical-prostatectomy-risk-group-distribution-in-a-european-multicenter-analysis-of-28-572-patients-towards-tailored-treatment
#6
Roderick van den Bergh, Giorgio Gandaglia, Derya Tilki, Hendrik Borgmann, Piet Ost, Christian Surcel, Massimo Valerio, Prasanna Sooriakumaran, Alberto Briganti, Markus Graefen, Henk van der Poel, Alexandre de la Taille, Francesco Montorsi, Guillaume Ploussard
BACKGROUND: Active surveillance (AS) has been increasingly proposed as the preferential initial management strategy for low-risk prostate cancer (PC), while in high-risk PC the indication for surgery has widened. OBJECTIVE: To evaluate the development of risk group distribution of patients undergoing radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: Retrospective database review of combined RP databases (2000-2015) of four large European centers (Créteil, Paris; San Rafaele, Milan; Martini Klinik, Hamburg; NKI, AvL, Amsterdam)...
August 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28799065/laparoscopic-inguinal-hernioplasty-after-robot-assisted-laparoscopic-radical-prostatectomy
#7
M Sakon, Y Sekino, M Okada, H Seki, Y Munakata
PURPOSE: To evaluate the efficacy and safety of laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair in patients who have undergone robot-assisted laparoscopic radical prostatectomy (RALP). METHODS: From July 2014 to December 2016, TAPP inguinal hernia repair was conducted in 40 consecutive patients who had previously undergone RALP. Their data were retrospectively analyzed as an uncontrolled case series. RESULTS: The mean operation time in patients who had previously undergone RALP was 99...
August 10, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28798829/does-surgical-delay-for-radical-prostatectomy-affect-patient-pathological-outcome-a-retrospective-analysis-from-a-canadian-cohort
#8
Marc Zanaty, Mansour Alnazari, Kelsey Lawson, Mounsif Azizi, Emad Rajih, Abdullah Alenizi, Pierre-Alain Hueber, Malek Meskawi, Cedric Lebacle, Thierry Lebeau, Serge Benayoun, Pierre I Karakiewicz, Assaad El-Hakim, Kevin C Zorn
INTRODUCTION: We sought to assess the impact of surgical wait time (SWT) to robot-assisted radical prostatectomy (RARP) on final pathological outcome. METHODS: A retrospective review of RARP patient records operated between 2006 and 2015 was conducted. SWT was defined as period from prostate biopsy to surgery. Primary outcome was the impact on postoperative Cancer of the Prostate Risk Assessment (CAPRA-S) score. Patients were stratified according to D'Amico risk categories...
August 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28798822/an-assessment-of-prostate-cancer-research-international-active-surveillance-prias-criteria-for-active-surveillance-of-clinically-low-risk-prostate-cancer-patients
#9
Vitor da Silva, Ilias Cagiannos, Luke T Lavallée, Ranjeeta Mallick, Kelsey Witiuk, Sonya Cnossen, James A Eastham, Dean A Fergusson, Chris Morash, Rodney H Breau
INTRODUCTION: Active surveillance is a strategy to delay or prevent treatment of indolent prostate cancer. The Prostate Cancer Research International: Active Surveillance (PRIAS) criteria were developed to select patients for prostate cancer active surveillance. The objective of this study was to compare pathological findings from PRIAS-eligible and PRIAS-ineligible clinically low-risk prostate cancer patients. METHODS: A D'Amico low-risk cohort of 1512 radical prostatectomy patients treated at The Ottawa Hospital or Memorial Sloan Kettering Cancer Centre between January 1995 and December 2007 was reviewed...
August 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28797228/oncological-outcomes-in-an-australian-cohort-according-to-the-new-prostate-cancer-grading-groupings
#10
K R Beckmann, A D Vincent, M E O'Callaghan, P Cohen, S Chang, M Borg, S M Evans, D M Roder, K L Moretti
BACKGROUND: A new 5-tiered grading grouping system has recently been endorsed for reporting of prostate cancer (PCa) grade to better reflect escalating risk of progression and cancer death. While several validations of the new grade groupings have been undertaken, most have involved centralised pathological review by specialist urological pathologists. METHODS: Participants included 4268 men with non-metastatic PCa diagnosed between 2006 and 2013 from the multi-institutional South Australia Prostate Cancer Clinical Outcomes Collaborative registry...
August 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28796995/heterogeneity-of-outcomes-in-d-amico-intermediate-risk-prostate-cancer-patients-after-radical-prostatectomy-influence-of-primary-and-secondary-gleason-score
#11
Matthew E Pollard, Adele R Hobbs, Young Suk Kwon, Maria Katsigeorgis, Hugh J Lavery, Adam Levinson, Adrien N Bernstein, Shemille A Collingwood, Simon J Hall, David B Samadi, Seyed Behzad Jazayeri
No abstract text is available yet for this article.
August 10, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/28794592/radiotherapy-is-associated-with-reduced-continence-outcomes-following-implantation-of-the-artificial-urinary-sphincter-in-men-with-post-radical-prostatectomy-incontinence
#12
Stephanie Guillaumier, Eskinder Solomon, Julie Jenks, Mahreen Pakzad, Rizwan Hamid, Jeremy Ockrim, Julian Shah, Tamsin Greenwell
OBJECTIVES: The objective of this study is to present the outcomes of men undergoing implantation of artificial urinary sphincter, after treatment for prostate cancer and also to determine the effect of radiotherapy on continence outcomes after artificial urinary sphincter (AUS) implantation. MATERIALS AND METHODS: A prospectively acquired database of all 184 patients having AUS insertion between 2002 and 2012 was reviewed, and demographic data, mode of prostate cancer treatment(s) before implantation, and outcome in terms of complete continence (pad free, leak free) were assessed...
July 2017: Urology Annals
https://www.readbyqxmd.com/read/28793907/risk-adapted-dose-intensified-postoperative-radiation-therapy-in-prostate-cancer-patients-using-a-simultaneous-integrated-boost-technique-applied-with-helical-tomotherapy
#13
Marcus Beck, Peter Wust, Tomasz Barelkowski, David Kaul, Alexander-Henry Thieme, Sascha Wecker, Waldemar Wlodarczyk, Volker Budach, Pirus Ghadjar
BACKGROUND: Postoperative adjuvant radiation therapy (ART) in T3 and R1 prostate cancer as well as salvage radiation therapy (SRT) in case of postoperative biochemical failure (BF) are established treatments. Dose-intensified postoperative radiation therapy (RT) schemes have shown superior biochemical control accompanied by increased toxicity rates. In our study we evaluate a novel risk adapted dose-intensified postoperative RT scheme. METHODS: A consecutive series of prostate cancer patients receiving postoperative RT after radical prostatectomy using helical Tomotherapy between 04/2012 and 04/2015 was analyzed retrospectively...
August 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28791870/end-2017-0250-or-r2
#14
Chandru P Sundaram
This study demonstrates the use of retrograde perfusion sphincterometry (RPS) to measure retrograde leak point pressure (RLPP) during robot assisted laparoscopic radical prostatectomy (RALP) before establishment of pneumoperitoneum, after insufflation; and before and after the use of an autologous sub-urethral sling using vas deferens, after the anastomosis was completed. The adjustment of the sling to achieve optimal sub-urethral support was achieved by measuring the RLPP intra operatively using RPS. While the study does demonstrate the use of a simple technique to study the RLPP during RALP, data to confirm that the sling helps with early urinary continence (EUC) is lacking...
August 9, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28791229/impact-of-bladder-dysfunction-in-the-management-of-post-radical-prostatectomy-stress-urinary-incontinence-a-review
#15
REVIEW
Derek B Hennessey, Nathan Hoag, Johan Gani
Bladder dysfunction is a relatively common urodynamic finding post radical prostatectomy (RP). It can be the sole cause of post prostatectomy incontinence (PPI) or may be found in association with stress urinary incontinence (SUI). The aim of this review is to provide a comprehensive review of the diagnosis and different treatments of post RP bladder dysfunction. A comprehensive literature review using medical search engines was performed. The search included a combination of the following terms, PPI, detrusor overactivity (DO), detrusor underactivity (DU), impaired compliance, anticholinergic, onabotulinumtoxinA (Botox(®)) and sacral neuromodulation (SNM)...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28791228/management-of-bladder-neck-stenosis-and-urethral-stricture-and-stenosis-following-treatment-for-prostate-cancer
#16
REVIEW
Helen L Nicholson, Yasser Al-Hakeem, Javier J Maldonado, Vincent Tse
The aim of this review is to examine all urethral strictures and stenoses subsequent to treatment for prostate cancer, including radical prostatectomy (RP), radiotherapy, high intensity focused ultrasound (HIFU) and cryotherapy. The overall majority respond to endoscopic treatment, including dilatation, direct visual internal urethrotomy (DVIU) or bladder neck incision (BNI). There are adjunct treatments to endoscopic management, including injections of corticosteroids and mitomycin C (MMC) and urethral stents, which remain controversial and are not currently mainstay of treatment...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28791222/an-objective-measurement-of-urinary-continence-recovery-with-pelvic-floor-physiotherapy-following-robotic-assisted-radical-prostatectomy
#17
Niranjan Jude Sathianathen, Liana Johnson, Damien Bolton, Nathan L Lawrentschuk
BACKGROUND: To assess the impact of structured pelvic floor physiotherapy including repeated standardized measurements in regaining urinary continence in those men who have undergone a robotic-assisted laparoscopic radical prostatectomy (RALP). METHODS: A retrospective database was created on men who had undergone a RALP while under the care of two senior urological surgeons between January 2013 and July 2016 and then took part in a formal pelvic floor rehabilitation program were included in the study...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28790846/the-association-between-spink1-and-clinical-outcomes-in-patients-with-prostate-cancer-a-systematic-review-and-meta-analysis
#18
Xingming Zhang, Xiaoxue Yin, Pengfei Shen, Guangxi Sun, Yaojing Yang, Jiandong Liu, Ni Chen, Hao Zeng
Evidence of the prognostic role of serine peptidase inhibitor Kazal type 1 (SPINK1) in prostate cancer (PCa) is controversial. The aim of this study was, therefore, to evaluate the association between SPINK1 and clinical outcomes in PCa. Searches were made of PubMed, Medline, Embase, and the China Biology Medicine disc (CBMdisc) up to January 2017. The Newcastle-Ottawa Scale was used to assess the risk of bias of included studies. RevMan software was used to perform meta-analysis, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method was employed for assessing the quality of the evidence...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28789947/impact-of-5%C3%AE-reductase-inhibitors-on-disease-reclassification-among-men-on-active-surveillance-for-localized-prostate-cancer-with-favorable-features
#19
Charles Dai, Vishnu Ganesan, Joseph Zabell, Yaw A Nyame, Nima Almassi, Daniel J Greene, Daniel Hettel, Chad Reichard, Samuel C Haywood, Hans Arora, Anna Zampini, Alice Crane, Jianbo Li, Ahmed Elshafei, Cristina Magi-Galluzzi, Robert J Stein, Khaled Fareed, Michael Gong, J Stephen Jones, Eric A Klein, Andrew J Stephenson
PURPOSE: To determine the effect of 5α-reductase inhibitors (5-ARI) on disease reclassification in men with prostate cancer optimally selected for active surveillance (AS). MATERIALS AND METHODS: A retrospective review identified 635 patients on AS between 2002-2015. Patients with favorable cancer features on repeat biopsy, defined as absence of Gleason upgrading, were included in the cohort. Patients were stratified by those who did or did not receive finasteride/dutasteride within 1 year of diagnosis...
August 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28789835/utility-of-anterior-zone-biopsy-in-men-enrolled-in-active-surveillance-for-prostate-cancer
#20
Allison S Glass, Neil B Pugashetti, Marc A Dall'Era, Christopher P Evans, Stanley A Yap
BACKGROUND: Anterior zone (AZ) disease is present in one-fifth of men with newly diagnosed prostate cancer and has been associated with poor pathologic features. However, anterior targeted biopsies are not a routine part of active surveillance (AS) protocols. Our purpose is to assess the utility of AZ sampling for prostate biopsy in patients undergoing surveillance for low-risk prostate cancer. METHODS: A prospective data collection of men enrolled in AS between 2006 and 2014 was performed...
July 14, 2017: Clinical Genitourinary Cancer
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