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https://www.readbyqxmd.com/read/27913152/development-and-validation-of-an-objective-scoring-tool-for-robot-assisted-radical-prostatectomy-prostatectomy-assessment-and-competency-evaluation-pace
#1
Ahmed A Hussein, Khurshid R Ghani, James Peabody, Richard Sarle, Ronney Abaza, Daniel Eun, Jim Hu, Michael Fumo, Brian Lane, Jeffrey Montgomery, Nobuyuki Hinata, Deborah Rooney, Bryan Comstock, Hei Kit Chan, Sridhar S Mane, James L Mohler, Gregory Wilding, David Miller, Khurshid A Guru
INTRODUCTION: and Background: Comprehensive training and skill acquisition by urologic surgeons are vital to optimize surgical outcomes and patient safety. We sought to develop and validate an objective and procedure specific tool to assess the quality of robot-assisted radical prostatectomy (RARP)-Prostatectomy Assessment and Competence Evaluation (PACE) METHODS: Development and content validation of PACE was performed by deconstruction of RARP into seven key domains utilizing the Delphi methodology...
November 29, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27913052/evaluation-of-erg-and-pten-protein-expression-in-cribriform-architecture-prostate-carcinomas
#2
Michelle R Downes, Swati Satturwar, Dominique Trudel, Theo H van der Kwast
ERG and PTEN have been suggested as potential prognostic markers in prostatic adenocarcinoma. We assessed the relationship between ERG and PTEN protein expression in cribriform architecture prostatic carcinomas and adjacent acinar non-cribriform carcinoma and determined the interobserver variability in assessment of these markers. A contemporary cohort of radical prostatectomy cases (n=246) were reviewed and cribriform architecture carcinomas (intraductal carcinoma and cribriform Gleason 4 carcinomas) were identified and confirmed with triple cocktail immunostaining...
October 26, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#3
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27910728/predictive-factors-associated-with-biochemical-recurrence-following-radical-prostatectomy-for-pathological-t2-prostate-cancer-with-negative-surgical-margins
#4
Fouad Aoun, Simone Albisinni, Benjamin Henriet, Bertrand Tombal, Roland Van Velthoven, Thierry Roumeguère
OBJECTIVE: The aim of this study was to determine factors associated with the development of biochemical recurrence (BCR) following radical prostatectomy in patients with pathological T2 prostate cancer and negative surgical margins. MATERIALS AND METHODS: This retrospective multicentre cohort study included 1252 consecutive patients with pT2 pN0/Nx and negative surgical margins on radical prostatectomy and without any adjuvant treatment, performed in three Belgian centres...
December 2, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27909616/is-extended-pelvic-lymph-node-dissection-for-prostate-cancer-the-only-recommended-option-a-systematic-over-view-of-the-literature
#5
REVIEW
Thomas Rees, Nicholas Raison, Mohammed Iqbal Sheikh, Zahra Jaffry, Sanjeev Madaan, Ben Challacombe, Kamran Ahmed, Prokar Dasgupta
OBJECTIVE: Pelvic lymph node dissection (PLND) is performed alongside radical prostatectomy as the most accurate method of staging prostate cancer. Yet the potential therapeutic benefits of lymphadenectomy are yet to be confirmed. MATERIAL AND METHODS: A PubMed database search was performed to identify all papers comparing techniques for PLND or none. The primary outcome measure was long term oncological outcomes. Studies looking at men with clinically localized prostate cancer at the time of radical prostatectomy who received no adjuvant treatment were included...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27909547/gastrointestinal-tract-access-for-urological-natural-orifice-transluminal-endoscopic-surgery
#6
REVIEW
Olga Miakicheva, Zachary Hamilton, Alp T Beksac, Sean W Berquist, Abd-Elrahman Hassan, Marc Holden, Ithaar H Derweesh
We conducted a literature review of natural orifice transluminal endoscopic surgery (NOTES), focusing on urologic procedures with gastrointestinal tract access, to update on the development of this novel surgical approach. As part of the methods, a comprehensive electronic literature search for NOTES was conducted using PubMed and Cochrane Library from March 2002 to February 2016 for papers reporting urologic procedures performed utilizing gastrointestinal tract access. A total of 11 peer-reviewed studies examining utility of gastrointestinal access for NOTES urologic procedures were noted, with the first report in 2007...
November 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27908376/urethral-strictures-and-artificial-urinary-sphincter-placement
#7
REVIEW
Jeremy B Myers, William O Brant, James N Hotaling, Sara M Lenherr
Patients undergoing artificial urinary sphincter (AUS) placement often have complex medical and surgical histories, such as radical prostatectomy, endoscopic treatment of urethral strictures, previous AUS placement, and prior open urethral surgery. Urethral strictures at the bladder neck, membranous urethra, or site of a previous AUS erosion are problems that profoundly affect the timing and treatment success of AUS placement. Understanding the complexities and outcomes in this subset of patients is the only way to inform shared decision making about treatment of urinary incontinence...
February 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27907923/association-between-the-surgical-apgar-score-and-perioperative-complications-after-radical-prostatectomy
#8
Matthias Orberger, Jüri Palisaar, Florian Roghmann, Ludger Mittelstädt, Petra Bischoff, Joachim Noldus, Björn Löppenberg
OBJECTIVE: To evaluate whether the Surgical Apgar Score (SAS) can identify patients who are at risk for perioperative adverse events (PAE) following radical prostatectomy for prostate cancer. PATIENTS AND METHODS: At a single academic institution, 994 patients undergoing radical prostatectomy between 2010 and 2013 were analyzed retrospectively. The SAS was calculated from anesthesia records, evaluated to predict PAE within a 30-day time period postoperatively; these events were classified according to standardized classification systems...
December 2, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27906997/role-of-genetic-polymorphisms-in-the-development-and-prognosis-of-sporadic-and-familial-prostate-cancer
#9
Sabrina T Reis, Nayara I Viana, Katia R M Leite, Erico Diogenes, Alberto A Antunes, Alexandre Iscaife, Adriano J Nesrallah, Carlo C Passerotti, Victor Srougi, José Pontes-Junior, Mary Ellen Salles, William C Nahas, Miguel Srougi
BACKGROUNDS: Our aim was to evaluate the role of 20 genetic polymorphisms in the development and prognosis of sporadic and familial PC. A case-control study of 185 patients who underwent radical prostatectomy from 1997 to 2011. These patients were divided into two groups based on their family history. Gleason grade, PSA value and pathological TNM 2002 stage were used as prognostic factors. Blood samples from 70 men without PC were used as controls. The SNPs were genotyped using a TaqMan® SNP Genotyping Assay Kit...
2016: PloS One
https://www.readbyqxmd.com/read/27900799/tissue-sources-for-accurate-measurement-of-germline-dna-genotypes-in-prostate-cancer-patients-treated-with-radical-prostatectomy
#10
Nima C Emami, Lancelote Leong, Eunice Wan, Erin L Van Blarigan, Matthew R Cooperberg, Imelda Tenggara, Peter R Carroll, June M Chan, John S Witte, Jeffry P Simko
BACKGROUND: Benign tissue from a tumor-containing organ is commonly the only available source for obtaining a patient's unmutated genome for use in cancer research. While it is critical to identify histologically normal tissue that is independent of the tumor lineage, few additional considerations are applied to the choice of this material for such measurements. METHODS: Normal formalin-fixed, paraffin-embedded seminal vesicle, and urethral tissues, in addition to whole blood, were collected from 31 prostate cancer patients having undergone radical prostatectomy...
November 30, 2016: Prostate
https://www.readbyqxmd.com/read/27896516/the-differential-impact-of-body-mass-index-and-the-feature-of-metabolic-syndrome-on-oncological-outcomes-following-different-surgical-procedures-in-japanese-men-with-prostate-cancer
#11
Masaki Shiota, Ario Takeuchi, Masaaki Sugimoto, Eiji Kashiwagi, Takashi Dejima, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Akira Yokomizo, Masatoshi Eto
PURPOSE: This study aimed to examine the differential impact of body mass index and the feature of metabolic syndrome (MetS; obesity, hypertension, diabetes mellitus, and dyslipidemia) on biochemical recurrence (BCR) following radical prostatectomy (RP) treatment for prostate cancer using different surgical procedures. METHODS: This study included 283 Japanese patients with clinically localized prostate cancer who were treated with RP between 2008 and 2012. The prognostic significance of overweight and the feature of MetS were analyzed according to surgical procedures...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27896239/prostate-specific-antigen-density-and-gleason-score-predict-adverse-pathologic-features-in-patients-with-clinically-localized-prostate-cancer
#12
Mohammad Reza Nowroozi, Seyed Ali Momeni, Solmaz Ohadian Moghadam, Elnaz Ayati, Afshin Mortazavi, Simin Arfae, Hassan Jamshidian, Mohsen Taherimahmoudi, Mohsen Ayati
BACKGROUND: According to recent studies, prostate cancer is the second most common cancer among Iranian men. Radical prostatectomy has been considered the gold standard treatment in patients with clinically localized prostate cancer. Gleason score, PSA density, and PSA velocity are some of the parameters used to predict adverse pathologic features. OBJECTIVES: The aim of this study was to evaluate the prognostic value of PSA density and Gleason score in predicting adverse pathologic features in patients with localized prostate cancer who undergo radical prostatectomy...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27894974/ccp-score-might-improve-the-current-risk-assessment-in-newly-diagnosed-prostate-cancer-patients
#13
Marco Oderda, Gabriele Cozzi, Lorenzo Daniele, Anna Sapino, Stefania Munegato, Giuseppe Renne, Ottavio De Cobelli, Paolo Gontero
OBJECTIVE: To assess whether cell-cycle progression (CCP)-score (Prolaris) can improve the current risk assessment in newly diagnosed PCa patients. CCP-score is a well validated prognostic assay predictive of PCa death, biochemical recurrence (BCR) and progression. METHODS: We evaluated CCP-score at biopsy in 52 patients newly diagnosed with PCa who underwent radical prostatectomy. CCP-score was calculated as average RNA expression of 31 CCP genes, normalized to 15 housekeeping genes...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27890683/the-effect-of-obesity-on-perioperative-outcomes-for-open-and-minimally-invasive-prostatectomy
#14
Scott C Johnson, Vignesh T Packiam, Shay Golan, Andrew J Cohen, Charles U Nottingham, Norm D Smith
OBJECTIVES: To compare the impact of obesity on perioperative outcomes between open radical prostatectomy (ORP) and minimally invasive prostatectomy (MIP). METHODS: Using the National Surgical Quality Improvement Program (NSQIP) public use files for 2008-2013, we identified patients undergoing prostatectomy using current procedural terminology codes. Those without BMI or comorbidity information were excluded. BMI was treated as a categorical variable according to the World Health Organization classification...
November 24, 2016: Urology
https://www.readbyqxmd.com/read/27890493/higher-number-of-transrectal-ultrasound-guided-prostate-biopsy-cores-is-associated-with-higher-blood-loss-and-perioperative-complications-in-robot-assisted-radical-prostatectomy
#15
A Carneiro, A Sivaraman, R Sanchez-Salas, I Nunes-Silva, M Baghdadi, V Srougi, E di Trapani, F Uriburu Pizzaro, S Doizi, E Barret, F Rozet, M Galiano, X Cathelineau
INTRODUCTION: The local inflammatory process after prostate biopsies can have a negative impact on functional outcomes of radical prostatectomy. There is no evidence in literature demonstrating its impact on radical prostatectomy. OBJECTIVES: To evaluate the impact of the number of TRUS core biopsies in the surgical morbidity and rate of positive margin on robot assisted radical prostatectomy (RARP). MATERIAL AND METHODS: A prospectively maintained database of 2,054 RARPs in a single institution...
November 24, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27889882/true-incidence-of-gleason-6-pathology-in-patients-with-metastatic-castration-resistant-prostate-cancer-mcrpc
#16
Alena Böker, Markus A Kuczyk, Mario W Kramer, Axel S Merseburger, Katharina Krüger, Florian Imkamp, Christoph A von Klot
INTRODUCTION: Recent evidence from histology studies regarding random prostate biopsies hint toward a relationship between higher biopsy Gleason score and the development of metastatic castration resistant prostate cancer (mCRPC). However, prostate biopsy underestimates final pathology in about one-third of patients. We evaluated the final whole gland pathology from radical prostatectomy exclusively in order to assess the true risk of progressing to the mCRPC state for patients with confirmed Gleason ≤6 prostate cancer...
November 26, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27889880/the-impact-of-extended-lymph-node-dissection-versus-neoadjuvant-therapy-with-limited-lymph-node-dissection-on-biochemical-recurrence-in-high-risk-prostate-cancer-patients-treated-with-radical-prostatectomy-a-multi-institutional-analysis
#17
Takuma Narita, Takuya Koie, Teppei Ookubo, Koji Mitsuzuka, Shintaro Narita, Hayato Yamamoto, Takamitsu Inoue, Shingo Hatakeyama, Sadafumi Kawamura, Tatsuo Tochigi, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama
The optimal treatment for high-risk prostate cancer (Pca) remains to be established. The current guidelines recommend extended pelvic lymph node dissection (e-PLND) for selected intermediate- and high-risk patients treated with RP. However, the indications, optimal extent, and therapeutic benefits of e-PLND remain unclear. The aim of this study was to assess whether e-PLND confers an oncological benefit for high-risk Pca compared to neoadjuvant luteinizing hormone-releasing hormone and estramustine (LHRH + EMP)...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27889781/striated-muscle-in-radical-prostatectomy-specimens-a-marker-of-apical-dissection-quality-and-an-independent-predictor-of-urinary-continence-after-endoscopic-extraperitoneal-radical-prostatectomy
#18
Daniel W Good, Andrew Wood, Laurence Stewart, Jens-Uwe Stolzenburg, Roman Ganzer, Jochen Neuhaus, Grant D Stewart, S Alan McNeill
INTRODUCTION: The study aimed to determine if the presence and amount of striated muscle on the apical sections of the cruciate sections of laparoscopic radical prostatectomy (LRP) specimens predict early and long-term urinary continence outcomes. PATIENTS AND METHODS: We conducted a retrospective review of our prospectively collected single surgeon LRP database. We identified patients based on their continence outcomes (continent (0 pads) or incontinent at 12 months), with an approximate even spread early continent and incontinent patients)...
November 26, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27889279/vitamin-k-epoxide-reductase-expression-and-prostate-cancer-risk
#19
Ben Yi Tew, Sumanta K Pal, Miaoling He, Tommy Tong, Huiqing Wu, JoAnn Hsu, Xueli Liu, Susan L Neuhausen, Jeremy O Jones
PURPOSE: Increasing evidence has demonstrated that men taking the anticoagulant warfarin have a lower risk of developing prostate cancer. This phenomenon is not observed in other cancers. We sought to determine if the target of warfarin, vitamin K epoxide reductase (VKOR), is expressed in benign and cancerous prostate tissues and if a functional single nucleotide polymorphism (SNP) in the VKOR gene is associated with prostate cancer risk. MATERIALS AND METHODS: The expression of VKOR was quantified by immunohistochemistry in an institutional series of 54 radical prostatectomy samples and metastatic biopsies, as well as in 40 other cancers and matched benign tissues on a tissue microarray...
November 23, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27888148/a-pilot-study-of-a-multimodal-treatment-paradigm-to-accelerate-drug-evaluations-in-early-stage-metastatic-prostate-cancer
#20
Matthew J O'Shaughnessy, Sean M McBride, Hebert Alberto Vargas, Karim A Touijer, Michael J Morris, Daniel C Danila, Vincent P Laudone, Bernard H Bochner, Joel Sheinfeld, Erica S Dayan, Lawrence P Bellomo, Daniel D Sjoberg, Glenn Heller, Michael J Zelefsky, James A Eastham, Peter T Scardino, Howard I Scher
OBJECTIVE: To evaluate a multimodal strategy aimed at treating all sites of disease that provides a rapid readout of success or failure in men presenting with noncastrate metastatic prostate cancers that are incurable with single modality therapy. PATIENTS AND METHODS: Twenty selected men with oligometastatic M1a (extrapelvic nodal disease) or M1b (bone disease) at diagnosis were treated using a multimodal approach that included androgen deprivation, radical prostatectomy plus pelvic lymphadenectomy (retroperitoneal lymphadenectomy in the presence of clinically positive retroperitoneal nodes), and stereotactic body radiotherapy to osseous disease and/or the primary site...
November 22, 2016: Urology
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