keyword
MENU ▼
Read by QxMD icon Read
search

Coefficient of variation

keyword
https://www.readbyqxmd.com/read/27926563/truth-in-reporting-how-data-capture-methods-obfuscate-actual-surgical-site-infection-rates-within-a-health-care-network-system
#1
Liliana Bordeianou, Christy E Cauley, Donna Antonelli, Sarah Bird, David Rattner, Matthew Hutter, Sadiqa Mahmood, Deborah Schnipper, Marc Rubin, Ronald Bleday, Pardon Kenney, David Berger
BACKGROUND: Two systems measure surgical site infection rates following colorectal surgeries: the American College of Surgeons National Surgical Quality Improvement Program and the Centers for Disease Control and Prevention National Healthcare Safety Network. The Centers for Medicare & Medicaid Services pay-for-performance initiatives use National Healthcare Safety Network data for hospital comparisons. OBJECTIVE: This study aimed to compare database concordance...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27925263/improved-consistency-in-2d-gel-electrophoresis-sheep-plasma-as-a-test-case
#2
Stuart Brown, Gillian Norris
Two-dimensional gel electrophoresis is a well proven proteomic technique, however sample specific optimization can often be necessary in order to get consistent quantitation. In particular, plasma samples are often smeared on 2D gels which makes spot matching difficult. A variety of different sample preparation and 2D methods were tested using sheep plasma, and it was found that lowering sample pH prior to precipitation, using a long voltage gradient for isoelectric focusing and the inclusion of carrier ampholytes in the electrode wicks, improved both the quality and consistency of spot resolution...
December 7, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27925006/cryopreservation-of-adventitious-roots-of-cleome-rosea-vahl-cleomaceae-using-a-vitrification-technique-and-assessment-of-genetic-stability
#3
L Da Silva Cordeiro, C Simoes-Gurgel, N Albarello
BACKGROUND:  Cleome rosea, a Brazilian native species, has medicinal potential. Previously a cryopreservation protocol for in vitro roots using the vitrification solution PVS2 has been developed. However, the genetic stability of the cryopreserved material is yet to be assessed. OBJECTIVES: To evaluate the effects of loading and vitrification solutions (PVS2 and PVS3) on post-cryopreservation recovery of C. rosea roots, and to assess their genetic stability using Random Amplified Polymorphic DNA (RAPD) markers...
July 2016: Cryo Letters
https://www.readbyqxmd.com/read/27924615/a-model-for-predicting-the-interindividual-variability-of-drug-drug-interactions
#4
M Tod, L Bourguignon, N Bleyzac, S Goutelle
Pharmacokinetic drug-drug interactions are frequently characterized and quantified by an AUC ratio (Rauc). The typical value of the AUC ratio in case of cytochrome-mediated interactions may be predicted by several approaches, based on in vitro or in vivo data. Prediction of the interindividual variability of Rauc would help to anticipate more completely the consequences of a drug-drug interaction. We propose and evaluate a simple approach for predicting the standard deviation (sd) of Ln(Rauc), a metric close to the interindividual coefficient of variation of Rauc...
December 6, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27924492/progression-of-gait-ataxia-in-patients-with-degenerative-cerebellar-disorders-a-4-year-follow-up-study
#5
Mariano Serrao, Giorgia Chini, Carlo Casali, Carmela Conte, Martina Rinaldi, Alberto Ranavolo, Christian Marcotulli, Luca Leonardi, Gaia Fragiotta, Fabiano Bini, Gianluca Coppola, Francesco Pierelli
In the present study, the progression of gait impairment in a group of patients with primary degenerative cerebellar ataxias was observed over a period of 4 years. A total of 30 patients underwent an initial gait analysis study, and thereafter only 12 were evaluated because they completed the 2- and 4-year follow-up evaluations. Time-distance parameters, trunk and joint range of motion (RoM), and variability parameters (e.g., coefficients of variation) were measured at the baseline and at each follow-up evaluation...
December 6, 2016: Cerebellum
https://www.readbyqxmd.com/read/27923575/scaling-methane-emissions-in-ruminants-and-global-estimates-in-wild-populations
#6
F J Pérez-Barbería
Methane (CH4) emissions by human activities have more than doubled since the 1700s, and they contribute to global warming. One of the sources of CH4 is produced by incomplete oxidation of feed in the ruminant's gut. Domestic ruminants produce most of the emissions from animal sources, but emissions by wild ruminants have been poorly estimated. This study (i) scales CH4 against body mass in 503 experiments in ruminants fed herbage, and assesses the effect of different sources of variation, using published and new data; and (ii) it uses these models to produce global estimates of CH4 emissions from wild ruminants...
December 3, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27922072/molecular-structure-and-dynamics-of-water-on-pristine-and-strained-phosphorene-wetting-and-diffusion-at-nanoscale
#7
Wei Zhang, Chao Ye, Linbi Hong, Zaixing Yang, Ruhong Zhou
Phosphorene, a newly fabricated two-dimensional (2D) nanomaterial, has emerged as a promising material for biomedical applications with great potential. Nonetheless, understanding the wetting and diffusive properties of bio-fluids on phosphorene which are of fundamental importance to these applications remains elusive. In this work, using molecular dynamics (MD) simulations, we investigated the structural and dynamic properties of water on both pristine and strained phosphorene. Our simulations indicate that the diffusion of water molecules on the phosphorene surface is anisotropic, with strain-enhanced diffusion clearly present, which arises from strain-induced smoothing of the energy landscape...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921155/comparison-of-two-and-three-dimensional-measurement-of-the-cobb-angle-in-scoliosis
#8
Ricarda Lechner, David Putzer, Dietmar Dammerer, Michael Liebensteiner, Christian Bach, Martin Thaler
PURPOSE: The Cobb angle as an objective measure is used to determine the progression of deformity, and is the basis in the planning of conservative and surgical treatment. However, studies have shown that the Cobb angle has two limitations: an inter- and intraobserver variability of the measurement is approximately 3-5 degrees, and high variability regarding the definition of the end vertebra. Scoliosis is a three-dimensional (3D) pathology, and 3D pathologies cannot be completely assessed by two-dimensional (2D) methods, like 2D radiography...
December 5, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27921075/longitudinal-monitoring-of-reconstructed-activity-concentration-on-a-clinical-time-of-flight-pet-ct-scanner
#9
Lawrence R MacDonald, Amy E Perkins, Chi-Hua Tung
Positron emission tomography (PET) images are potential quantitative biomarkers. Understanding long-term (months/years) biomarker variability is important for establishing confidence intervals on studies using such biomarkers over these time frames. PET biomarkers are derived from activity concentration ([Formula: see text]) extracted from PET images. Over 30 months, we measured the stability of decay-normalized counts ([Formula: see text]) and [Formula: see text] by scanning the same 4.5-cm-diameter Ge-68 cylinder weekly, the same Na-22 point source daily, and a refilled 20-cm F-18 cylinder phantom monthly on a clinical TOF-PET/CT scanner...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27920527/pharmacokinetics-and-safety-of-dts-108-a-human-oligopeptide-bound-to-sn-38-with-an-esterase-sensitive-cross-linker-in-patients-with-advanced-malignancies-a-phase-i-study
#10
Romain Coriat, Sandrine J Faivre, Olivier Mir, Chantal Dreyer, Stanislas Ropert, Mohammed Bouattour, Robert Desjardins, François Goldwasser, Eric Raymond
BACKGROUND: DTS-108 is a hydrosoluble prodrug, where the SN-38 moiety is covalently linked to a 20-amino acid vector peptide by a specific esterase-sensitive cross-linker, releasing 7-ethyl-10-hydroxycampthotecin (SN-38) by esterase bond cleavage. METHODS: The pharmacokinetics of DTS-108, adverse events graded according to NCI-CTCv3.1, dose-limiting toxicities at cycle 1, the maximum tolerated dose (MTD), and the recommended Phase II dose (RP2D) of intravenous DTS-108 (1-2 hours) every 2 weeks were evaluated in a first-in-human Phase I study in patients with advanced/metastatic carcinomas, according to an accelerated dose escalation design...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27919923/clonality-increases-with-snow-depth-in-the-arctic-dwarf-shrub-empetrum-hermaphroditum
#11
Miriam J Bienau, R Lutz Eckstein, Annette Otte, Walter Durka
PREMISE OF THE STUDY: Vegetative reproduction and spread through clonal growth plays an important role in arctic-alpine ecosystems with short cool growing seasons. Local variation in winter snow accumulation leads to discrete habitat types that may provide divergent conditions for sexual and vegetative reproduction. Therefore, we studied variation in clonal structure of a dominant, evergreen, dwarf shrub (Empetrum nigrum s.l. with the two taxa E. nigrum L. s.s. and E. hermaphroditum Hagerup) along a snow cover gradient and compared clonal diversity and spatial genetic structure between habitats...
December 5, 2016: American Journal of Botany
https://www.readbyqxmd.com/read/27919562/impact-of-pre-equilibration-and-diffusion-limited-release-kinetics-on-effluent-concentration-in-column-leaching-tests-insights-from-numerical-simulations
#12
Michael Finkel, Peter Grathwohl
Column leaching tests have become a standard method for assessing leaching of pollutants from materials used, e.g., for road and railway constructions and in landscaping measures. Column tests showed to be practical in laboratories yielding robust and reproducible results. However, considerable uncertainty still exists related particularly to the degree of equilibration of the pore water with the solids during preparation (pre-equilibration) and percolation of the column. We analyse equilibration time scales and sensitivity of concentrations in column leachate with respect to initial conditions in a series of numerical experiments covering a broad spectrum of material and solute properties...
December 2, 2016: Waste Management
https://www.readbyqxmd.com/read/27918708/patient-specific-hip-fracture-strength-assessment-with-microstructural-mr-imaging-based-finite-element-modeling
#13
Chamith S Rajapakse, Alexandra Hotca, Benjamin T Newman, Austin Ramme, Shaleen Vira, Elizabeth A Kobe, Rhiannon Miller, Stephen Honig, Gregory Chang
Purpose To describe a nonlinear finite element analysis method by using magnetic resonance (MR) images for the assessment of the mechanical competence of the hip and to demonstrate the reproducibility of the tool. Materials and Methods This prospective study received institutional review board approval and fully complied with HIPAA regulations for patient data. Written informed consent was obtained from all subjects. A nonlinear finite element analysis method was developed to estimate mechanical parameters that relate to hip fracture resistance by using MR images...
December 2, 2016: Radiology
https://www.readbyqxmd.com/read/27918313/a-comparison-of-the-mechanical-measures-used-for-assessing-orthodontic-mini-implant-stability
#14
Yara K Hosein, S Jeffrey Dixon, Amin S Rizkalla, Ali Tassi
PURPOSE: Mechanical loosening remains a common complication associated with mini-implant failure. The purpose of this study was to compare common mechanical measures of mini-implant stability to determine their association and reliability. MATERIALS AND METHODS: Ninety self-drilling orthodontic mini-implants from 6 manufacturers were inserted into artificial bone blocks. Insertion torques (ITs) and Periotest values (PVs) were measured. Subsequently, mini-implants underwent pull-out testing for measures of pull-out load (POL) and screw displacement (ScrD)...
December 1, 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27917919/niptric-an-online-tool-for-clinical-interpretation-of-non-invasive-prenatal-testing-nipt-results
#15
Birgit Sikkema-Raddatz, Lennart F Johansson, Eddy N de Boer, Elles M J Boon, Ron F Suijkerbuijk, Katelijne Bouman, Catia M Bilardo, Morris A Swertz, Martijn Dijkstra, Irene M van Langen, Richard J Sinke, Gerard J Te Meerman
To properly interpret the result of a pregnant woman's non-invasive prenatal test (NIPT), her a priori risk must be taken into account in order to obtain her personalised a posteriori risk (PPR), which more accurately expresses her true likelihood of carrying a foetus with trisomy. Our aim was to develop a tool for laboratories and clinicians to calculate easily the PPR for genome-wide NIPT results, using diploid samples as a control group. The tool takes the a priori risk and Z-score into account. Foetal DNA percentage and coefficient of variation can be given default settings, but actual values should be used if known...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917112/reproducibility-and-reliability-of-quantitative-and-weighted-t1-and-t2-%C3%A2-mapping-for-myelin-based-cortical-parcellation-at-7-tesla
#16
Roy A M Haast, Dimo Ivanov, Elia Formisano, Kâmil Uludaǧ
Different magnetic resonance (MR) parameters, such as R1 (=1/T1) or T2(∗), have been used to visualize non-invasively the myelin distribution across the cortical sheet. Myelin contrast is consistently enhanced in the primary sensory and some higher order cortical areas (such as MT or the cingulate cortex), which renders it suitable for subject-specific anatomical cortical parcellation. However, no systematic comparison has been performed between the previously proposed MR parameters, i.e., the longitudinal and transversal relaxation values (or their ratios), for myelin mapping at 7 Tesla...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27917017/determination-of-coefficient-defining-leaf-area-development-in-different-genotypes-plant-types-and-planting-densities-in-peanut-arachis-hypogeae-l
#17
Oumarou Halilou, Halime Mahamat Hissene, José A Clavijo Michelangeli, Falalou Hamidou, Thomas R Sinclair, Afshin Soltani, Saadou Mahamane, Vincent Vadez
Rapid leaf area development may be attractive under a number of cropping conditions to enhance the vigor of crop establishment and allow rapid canopy closure for maximizing light interception and shading of weed competitors. This study was undertaken to determine (1) if parameters describing leaf area development varied among ten peanut (Arachis hypogeae L.) genotypes grown in field and pot experiments, (2) if these parameters were affected by the planting density, and (3) if these parameters varied between Spanish and Virginia genotypes...
December 2016: Field Crops Research
https://www.readbyqxmd.com/read/27916121/development-of-an-indirect-elisa-for-the-determination-of-ethyl-carbamate-in-chinese-rice-wine
#18
Lin Luo, Hong-Tao Lei, Jin-Yi Yang, Gong-Liang Liu, Yuan-Ming Sun, Wei-Dong Bai, Hong Wang, Yu-Dong Shen, Sui Chen, Zhen-Lin Xu
The widespread occurrence of ethyl carbamate (EC, 89.09 Da), a group 2A carcinogen, in fermented foods and alcoholic beverages has raised worldwide public health concern. Immunoassay for EC is unavailable due to the simple and small structure of EC. In this work, an initial attempt to produce antibody specific for EC, by using 4-((ethoxycarbonyl)amino)butanoic acid as hapten, was made but failed. However, since EC can easily react with 9-xanthydrol to form xanthyl ethyl carbamate (XEC), two haptens based on XEC structure were designed and synthesized...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27915135/primary-stability-and-viscoelastic-displacement-of-mini-implant-system-under-loading
#19
Jim Lee, Yong-Hoon Jeong, Joseph Pittman, Toru Deguchi, William M Johnston, Henry W Fields, Do-Gyoon Kim
BACKGROUND: The objectives of the current study were to examine the effects of mini-implant diameters on 1) primary stability before bone properties are changed by active peri-implant bone remodeling and 2) the time-dependent displacement of mini-implant systems in bone under a functional radial loading and their associations with bone mineral density. METHODS: Twenty one, 8mm length mini-implants (7 each for 1.4mm, 1.6mm, and 2mm diameters) were placed in mandibular sections of human cadavers (4 males and 3 females, average 69...
November 24, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27914794/modeling-the-secondary-drying-stage-of-freeze-drying-development-and-validation-of-an-excel-based-model
#20
Ekneet K Sahni, Michael J Pikal
Although several mathematical models of primary drying have been developed over the years, with significant impact on the efficiency of process design, models of secondary drying have been confined to highly complex models. The simple-to-use Excel-based model developed here is, in essence, a series of steady state calculations of heat and mass transfer in the 2 halves of the dry layer where drying time is divided into a large number of time steps, where in each time step steady state conditions prevail. Water desorption isotherm and mass transfer coefficient data are required...
November 30, 2016: Journal of Pharmaceutical Sciences
keyword
keyword
3544
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"