keyword
MENU ▼
Read by QxMD icon Read
search

Double blinded randomized controlled

keyword
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#1
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29655955/employment-and-paid-work-among-participants-in-a-randomized-controlled-trial-comparing-diacetylmorphine-and-hydromorphone
#2
Mohammadali Nikoo, Marc Vogel, Fiona Choi, Michael J Song, Jensen Burghardt, Zafar Zafari, Katarina Tabi, Anastasia Frank, Skye Barbic, Christian Schütz, Kerry Jang, Michael Krausz
BACKGROUND: Employment is one of the less studied but a significant outcome of medication-assisted treatment. Thus, we aimed to explore employment outcomes of medication-assisted treatment with hydromorphone (HDM) or diacetylmorphine (DAM). The secondary aim was to estimate characteristics of this population as well as treatment-related factors associated with these outcomes. METHODS: This was a secondary analysis of a randomized, double blind controlled trial. A total of 102 and 100 participants were randomized to receive injectable DAM or HDM for 6 months respectively...
April 12, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29655779/postprandial-glucose-and-insulin-response-to-a-high-fiber-muffin-top-containing-resistant-starch-type-4-in-healthy-adults-a-double-blind-randomized-controlled-trial
#3
Maria L Stewart, J Paul Zimmer
OBJECTIVES: VERSAFIBE™ 2470 resistant starch (RS) is an RS type 4 that is derived from high-amylose maize starch,70% total dietary fiber (TDF; AOAC method 2009.01). This was a randomized, double-blind, crossover study to evaluate the postprandial blood glucose and insulin responses of healthy adults (n = 28) after the consumption of a muffin top made with VERSAFIBE™ 2470 RS (11.6 g TDF fiber muffin top) or a control muffin top (0.9 g TDF). METHODS: The muffin tops were matched for weight, total carbohydrate, sugars, protein, and fat...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29653390/fondaparinux-versus-nadroparin-for-thromboprophylaxis-following-minimally-invasive-esophagectomy-a-randomized-controlled-trial
#4
Jieqiong Song, Lizhen Xuan, Wei Wu, Yaxing Shen, Lijie Tan, Ming Zhong
BACKGROUND: The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS: We conducted a randomized, double-blind, treatment-controlled study. Consecutive patients undergoing MIE randomly received a single dose of either nadroparin 2850 AxaIU (Group H) or fondaparinux 2.5 mg (Group F) daily...
April 4, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29653338/long-term-effects-of-adjunctive-perampanel-on-cognition-in-adolescents-with-partial-seizures
#5
Jesus E Piña-Garza, Lieven Lagae, Vicente Villanueva, J Ben Renfroe, Antonio Laurenza, Betsy Williams, Dinesh Kumar, Kimford J Meador
OBJECTIVE: The aim of this study was to evaluate long-term effects of adjunctive perampanel on cognition, efficacy, growth, safety, and tolerability in adolescents with inadequately controlled partial seizures. METHODS: Study 235, a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase II study with an open-label extension phase (NCT01161524), was primarily designed to assess the effects of adjunctive perampanel on cognition. Patients (aged ≥12 to <18years) had a diagnosis of epilepsy with inadequately controlled partial seizures, with or without secondary generalization, despite receiving 1-3 antiepileptic drugs...
April 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29652929/immunogenicity-and-safety-of-three-consecutive-production-lots-of-the-non-replicating-smallpox-vaccine-mva-a-randomised-double-blind-placebo-controlled-phase-iii-trial
#6
Edgar Turner Overton, Steven J Lawrence, Eva Wagner, Katrin Nopora, Siegfried Rösch, Philip Young, Darja Schmidt, Christian Kreusel, Sonja De Carli, Thomas P Meyer, Heinz Weidenthaler, Nathaly Samy, Paul Chaplin
BACKGROUND: Modified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral immunogenic equivalence of three consecutively manufactured MVA production lots, and to confirm the safety and tolerability of MVA focusing on cardiac readouts. METHODS: The trial was conducted at 34 sites in the US. Vaccinia-naïve adults aged 18-40 years were randomly allocated to one of four groups using a 1:1:1:1 randomization scheme...
2018: PloS One
https://www.readbyqxmd.com/read/29652567/a-khorasan-wheat-based-replacement-diet-improves-risk-profile-of-patients-with-nonalcoholic-fatty-liver-disease-nafld-a-randomized-clinical-trial
#7
Monica Dinu, Anne Whittaker, Giuditta Pagliai, Ilaria Giangrandi, Barbara Colombini, Anna Maria Gori, Claudia Fiorillo, Matteo Becatti, Alessandro Casini, Stefano Benedettelli, Francesco Sofi
OBJECTIVE: KAMUT khorasan is an ancient grain with widely acclaimed health benefits. The aim of this study was to investigate the effects of a replacement diet with ancient khorasan wheat products in patients with NAFLD, in comparison to a similar replacement diet with control products made from organic semi-whole-grain modern wheat. METHODS: Forty NAFLD patients (12 M/28 F; age 55.2 ± 10.4 years) with mild to moderate liver steatosis were included. The experimental design was a randomized, double-blind, parallel-arm study with 20 participants assigned to consume either KAMUT khorasan or control wheat products (pasta, bread, crackers, biscuits) over a 3-month period...
April 13, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29651970/randomized-double-blind-placebo-controlled-trial-of-celecoxib-for-prevention-of-skin-toxicity-in-patients-receiving-radiation-therapy-for-breast-cancer
#8
Arash Ghasemi, Behzad Danesh, Jamshid Yazdani, Seyed Jalal Hosseinimehr
BACKGROUND: The skin toxicity-induced by ionizing radiation may limit the duration of treatment and may lead discomfort to quality life of patients during radiotherapy. OBJECTIVE: The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of oral administration of celecoxib (CLX) on the acute radiation-induced skin toxicity in patients with breast cancer. METHODS: Sixty breast cancer patients were randomly assigned to use CLX (400 mg per day) or placebo capsules during radiotherapy...
April 11, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29651862/four-weeks-of-%C3%AE-alanine-supplementation-improves-high-intensity-game-activities-in-water-polo
#9
Gabriel Motta Pinheiro Brisola, Elvis de Souza Malta, Paulo Roberto Pereira Santiago, Luiz Henrique Palucci Vieira, Alessandro Moura Zagatto
OBJECTIVES: The present study aimed to investigate whether four weeks of β-alanine supplementation improves total distance covered, distance covered and time spent in different speed zones, and sprint numbers during a simulated water polo game. DESIGN: The study design was double-blind, parallel and placebo controlled. Eleven male water polo players participated in the study, divided randomly into two homogeneous groups (placebo and β-alanine groups). METHODS: The participants performed a simulated water polo game before and after the supplementation period (4 weeks)...
April 13, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29651711/baclofen-to-prevent-relapse-in-gamma-hydroxybutyrate-ghb-dependent-patients-a-multicentre-open-label-non-randomized-controlled-trial
#10
Harmen Beurmanjer, Rama M Kamal, Cor A J de Jong, Boukje A G Dijkstra, Arnt F A Schellekens
BACKGROUND: Gamma-hydroxybutyrate (GHB) dependence is associated with a severe, potentially lethal, withdrawal syndrome and relapse rates as high as 60% within 3 months of detoxification. Baclofen has been shown to decrease self-administration of GHB in mice and reduce relapse in a case series of GHB-dependent patients. Controlled studies on the effectiveness of baclofen to prevent relapse in GHB-dependent patients are lacking. AIM: The aim of this study was to assess effectiveness of baclofen in preventing relapse in GHB-dependent patients...
April 12, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29650440/the-effectiveness-of-lactobacillus-reuteri-dsm-17938-as-an-adjunct-to-macrogol-in-the-treatment-of-functional-constipation-in-children-a-randomized-double-blind-placebo-controlled-multicentre-trial
#11
Agnieszka Wegner, Aleksandra Banaszkiewicz, Jaroslaw Kierkus, Piotr Landowski, Anna Korlatowicz-Bilar, Sabina Wiecek, Jaroslaw Kwiecien, Agnieszka Gawronska, Lukasz Dembinski, Grazyna Czaja-Bulsa, Piotr Socha
OBJECTIVE: Constipation is one of the most common problems among children, with a prevalence ranging from 7 to 30%. It is treated with defecation training and laxative medications. However, many patients do not respond to the standard therapy. There is, therefore, an increasing interest in probiotics for the treatment of functional constipation. STUDY DESIGN: The aim of this study was to assess the effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional, intractable constipation in children...
April 9, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29650236/re-water-a-double-blind-randomized-controlled-trial-of-aquablation-vs-transurethral-resection-of-the-prostate-in-benign-prostatic-hyperplasia
#12
Stephan Madersbacher
No abstract text is available yet for this article.
April 9, 2018: European Urology
https://www.readbyqxmd.com/read/29649996/the-effects-of-synbiotic-supplementation-on-hormonal-status-biomarkers-of-inflammation-and-oxidative-stress-in-subjects-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#13
Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria...
April 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29649425/effects-of-grape-consumption-on-biomarkers-of-inflammation-endothelial-function-and-pbmc-gene-expression-in-obese-subjects
#14
Allison S Bardagjy, Qian Hu, Kathryn A Giebler, Addison Ford, Francene M Steinberg
This study investigated effects of grape consumption on biomarkers of cardiovascular health in obese participants in both postprandial and chronic settings. Twenty obese adults participated in this randomized, placebo controlled, double-blinded crossover trial. Participants were randomized to consume 60 g freeze-dried polyphenol-rich whole grape powder (GP) or placebo (PBO) followed by high fat high carbohydrate (HFHC) meal challenge. Following acute challenge, participants consumed their respective treatment daily for 4 weeks to determine effects of chronic consumption...
April 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29649082/transcutaneous-electrical-nerve-stimulation-reduces-resting-pain-in-head-and-neck-cancer-patients-a-randomized-and-placebo-controlled-double-blind-pilot-study
#15
Jennifer E Lee, Carryn M Anderson, Yelena Perkhounkova, Brittany M Sleeuwenhoek, Rebecca R Louison
BACKGROUND: Individuals receiving radiation for head and neck cancer (HNC) often develop painful oral mucositis that impairs function, possibly leading to feeding tubes, hospitalization, and treatment delays. Although pharmacologic medications provide some relief, many report inadequate analgesia and adverse effects. Transcutaneous electrical nerve stimulation (TENS) is a safe, nonpharmacologic intervention; it decreases pain and analgesics and improves function, yet no studies examined TENS for HNC...
April 11, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29649056/topical-aloe-vera-gel-for-accelerated-wound-healing-of-split-thickness-skin-graft-donor-sites-a-double-blind-randomized-controlled-trial-and-systematic-review
#16
Chairat Burusapat, Monlada Supawan, Chatchai Pruksapong, Anont Pitiseree, Chaichoompol Suwantemee
BACKGROUND: Aloe vera has been used to treat wounds since ancient times. However, the efficacy of Aloe vera for burns and split-thickness skin graft (STSG) donor sites are inconclusive. METHODS: A double-blind, randomized, controlled trial was conducted. Patients who underwent STSG harvesting from the thigh were included. STSG donor sites were divided into two groups: Aloe vera group and placebo group. The visual analogue scale (VAS) score evaluated pain and complete epithelialization was assessed...
March 30, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29648856/treatment-expectancy-and-working-alliance-in-pharmacotherapy-as-predictors-of-outcomes-in-complicated-grief
#17
Elizabeth M Goetter, Christine M Mauro, Xin Qiu, Natalia A Skritskaya, Charles F Reynolds, Sidney Zisook, M Katherine Shear, Naomi M Simon
OBJECTIVE: Nonspecific factors, such as treatment outcome expectancy and working alliance, can influence treatment outcome. No studies to date have examined the role of expectancy and alliance on pharmacotherapy outcomes in individuals with complicated grief (CG). METHOD: This secondary analysis of a larger randomized, control trial (RCT) examined the relationship between pharmacotherapy expectancy and alliance on treatment outcome in adults with CG who were participating in a multisite, double-blind, RCT examining the efficacy of citalopram and complicated grief treatment (CGT)...
April 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29645341/effects-on-the-glucagon-response-to-hypoglycaemia-during-dpp-4-inhibition-in-elderly-subjects-with-type-2-diabetes-a-randomized-placebo-controlled-study
#18
Johan Farngren, Margaretha Persson, Bo Ahrén
AIMS: Maintained glucagon response to hypoglycaemia is important as a safeguard against hypoglycaemia during glucose-lowering therapy in type 2 diabetes. During recent years, DPP-4 (dipeptidyl peptidase-4) inhibition has become more commonly used in elderly patients. However, whether DPP-4 inhibition affects the glucagon response to hypoglycaemia in the elderly is not known and was the aim of this study. METHODS: In a single-center, double-blind, randomized, placebo-controlled crossover study, 28 subjects with metformin-treated type 2 diabetes (17 males, 11 females; mean 74 years (range 65-86 years), mean HbA1c 51...
April 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29645317/slow-infusion-of-low-hyphen-dose-ketamine-reduces-bothersome-side-effects-compared-to-iv-push-a-double-hyphen-blind-double-dummy-randomized-controlled-trial
#19
Eben J Clattenburg, Christian Hailozian, Daniel Haro, Tina Yoo, Stefan Flores, Derex Louie, Andrew A Herring
STUDY OBJECTIVE: We compared the analgesic efficacy and incidence of side effects when low{\hyphen}dose (0.3 mg{\sol}kg) ketamine (LDK) is administered as a slow infusion (SI) over 15 minutes versus an intravenous push (IVP) over one minute. METHODS: This was a prospective, randomized, double blind, double dummy, placebo{\hyphen}controlled trial of adult ED patients presenting with moderate to severe pain (numerical rating score ≥ 5). Patients received ketamine 0...
April 12, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29645285/cardiovascular-safety-of-the-%C3%AE-3-adrenoceptor-agonist-mirabegron-and-the-antimuscarinic-agent-solifenacin-in-the-synergy-trial
#20
William B White, Christopher Chapple, Christian Gratzke, Sender Herschorn, Dudley Robinson, Jeffrey Frankel, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Robert van Maanen, Michael A Weber
There have been concerns that treatment of overactive bladder with β3 -adrenoceptor agonists may potentially have detrimental cardiovascular (CV) side effects. We evaluated the CV safety of mirabegron, a β3 -adrenoceptor agonist, alone and in combination therapy with the antimuscarinic agent solifenacin. The SYNERGY trial was a multinational, multicenter, randomized, double-blind, parallel-group, placebo and active-controlled phase 3 trial. Patients were randomized to receive solifenacin 5 mg + mirabegron 50 mg (combination 5 + 50 mg), solifenacin 5 mg + mirabegron 25 mg (combination 5 + 25 mg), solifenacin 5 mg monotherapy, mirabegron 25 mg monotherapy, mirabegron 50 mg monotherapy, or placebo for a 12-week double-blind treatment period...
April 12, 2018: Journal of Clinical Pharmacology
keyword
keyword
35436
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"