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bone marrow in scar treatment

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https://www.readbyqxmd.com/read/27885959/bone-marrow-stromal-cell-sheets-may-promote-axonal-regeneration-and-functional-recovery-with-suppression-of-glial-scar-formation-after-spinal-cord-transection-injury-in-rats
#1
Akinori Okuda, Noriko Horii-Hayashi, Takayo Sasagawa, Takamasa Shimizu, Hideki Shigematsu, Eiichiro Iwata, Yasuhiko Morimoto, Keisuke Masuda, Munehisa Koizumi, Manabu Akahane, Mayumi Nishi, Yasuhito Tanaka
OBJECTIVE Transplantation of bone marrow stromal cells (BMSCs) is a theoretical potential as a therapeutic strategy in the treatment of spinal cord injury (SCI). Although a scaffold is sometimes used for retaining transplanted cells in damaged tissue, it is also known to induce redundant immunoreactions during the degradation processes. In this study, the authors prepared cell sheets made of BMSCs, which are transplantable without a scaffold, and investigated their effects on axonal regeneration, glial scar formation, and functional recovery in a completely transected SCI model in rats...
November 25, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27865438/evaluation-of-bone-marrow-derived-mesenchymal-stem-cells-for-full-thickness-wound-healing-in-comparison-to-tissue-engineered-chitosan-scaffold-in-rabbit
#2
Mohammad Hossein Rajabian, Gholam Hossein Ghorabi, Bita Geramizadeh, Safoura Sameni, Maryam Ayatollahi
BACKGROUND: Chronic wounds present a major challenge in modern medicine. Even under optimal conditions, the healing process may lead to scarring and fibrosis. The ability of mesenchymal stem cells (MSCs) to differentiate into other cell types makes these cells an attractive therapeutic tool for cell transplantation. Both tissue-engineered construct and MSC therapy are among the current wound healing procedures and potential care. Chitosan has been widely applied in tissue engineering because of its biocompatibility and biodegradability...
November 9, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27804974/mesenchymal-stem-cells-combined-with-hepatocyte-growth-factor-therapy-for-attenuating-ischaemic-myocardial-fibrosis-assessment-using-multimodal-molecular-imaging
#3
Huizhu Chen, Rui Xia, Zhenlin Li, Lizhi Zhang, Chunchao Xia, Hua Ai, Zhigang Yang, Yingkun Guo
Clinically, myocardial fibrosis is increasingly being recognized as a new therapeutic target for ischaemic heart diseases. The aim of this study was to investigate whether noninvasive multimodal molecular imaging could be used to dynamically assess whether the combination of bone marrow mesenchymal stem cells (BMSCs) and hepatocyte growth factor (HGF) therapy can synergistically attenuate myocardial fibrosis after myocardial infarction (MI). MI was induced in 28 rats by coronary ligation with subsequent injection of BMSCs/HGF, BMSCs, HGF, or saline into the border zone under echocardiography guidance...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27637759/mesenchymal-stromal-cell-injection-promotes-vocal-fold-scar-repair-without-long-term-engraftment
#4
R S Bartlett, J T Guille, X Chen, M B Christensen, S F Wang, S L Thibeault
BACKGROUND: Regenerative medicine holds promise for restoring voice in patients with vocal fold scarring. As experimental treatments approach clinical translation, several considerations remain. Our objective was to evaluate efficacy and biocompatibility of four bone marrow mesenchymal stromal cell (BM-MSC) and tunable hyaluronic acid based hydrogel (HyStem-VF) treatments for vocal fold scar using clinically acceptable materials, a preclinical sample size and a dosing comparison. METHODS: Vocal folds of 84 rabbits were injured and injected with four treatment variations (BM-MSC, HyStem-VF, and BM-MSC in HyStem-VF at two concentrations) 6 weeks later...
October 2016: Cytotherapy
https://www.readbyqxmd.com/read/27630673/points-regarding-cell-transplantation-for-the-treatment-of-spinal-cord-injury
#5
REVIEW
Chizuka Ide, Kenji Kanekiyo
Transplantation of somatic cells, including bone marrow stromal cells (BMSCs), bone marrow mononuclear cells (BMNCs), and choroid plexus epithelial cells (CPECs), enhances the outgrowth of regenerating axons and promotes locomotor improvements. They are not integrated into the host spinal cord, but disappear within 2-3 weeks after transplantation. Regenerating axons extend at the spinal cord lesion through the astrocyte-devoid area that is filled with connective tissue matrices. Regenerating axons have characteristics of peripheral nerves: they are associated with Schwann cells, and embedded in connective tissue matrices...
July 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27612519/stem-cell-based-tissue-engineered-laryngeal-replacement
#6
Tahera Ansari, Peggy Lange, Aaron Southgate, Karin Greco, Carla Carvalho, Leanne Partington, Anthony Bullock, Sheila MacNeil, Mark W Lowdell, Paul D Sibbons, Martin A Birchall
: : Patients with laryngeal disorders may have severe morbidity relating to swallowing, vocalization, and respiratory function, for which conventional therapies are suboptimal. A tissue-engineered approach would aim to restore the vocal folds and maintain respiratory function while limiting the extent of scarring in the regenerated tissue. Under Good Laboratory Practice conditions, we decellularized porcine larynges, using detergents and enzymes under negative pressure to produce an acellular scaffold comprising cartilage, muscle, and mucosa...
September 9, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27560658/immunomodulatory-capacity-of-the-local-mesenchymal-stem-cells-transplantation-after-severe-skeletal-muscle-injury-in-female-rats
#7
Mona A M Helal, Noura E M Shaheen, Fatma A Abu Zahra
CONTEXT: Cell therapy technique with stem cells is a very attractive strategy for the treatment of muscle disorders. OBJECTIVE: The objective of this study was to investigate the mechanism of local transplantation of mesenchymal stem cells (MSCs) which could contribute to skeletal muscle healing. MATERIALS AND METHODS: Female rats were divided into three equal groups as the following: group 1, the negative control group (untreated group), group 2, sham-treated group, rats with muscle injuries involving volumetric muscle loss (VML) of adductor brevis muscle and injected locally with phosphate-buffered saline (PBS) 0...
August 25, 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27543341/preconditioning-of-mesenchymal-stem-cells-with-2-4-dinitrophenol-improves-cardiac-function-in-infarcted-rats
#8
Irfan Khan, Anwar Ali, Muhammad Aleem Akhter, Nadia Naeem, Maqsood Ahmed Chotani, Tuba Mustafa, Asmat Salim
AIMS: The aim of this study is to determine if preconditioning of bone marrow derived mesenchymal stem cells (MSCs) with 2,4-dinitrophenol (DNP) improves survival of transplanted stem cells in a rat model of myocardial infarction (MI), and to asses if this strategy has measurable impact on cardiac function. MAIN METHODS: MSCs were preconditioned with DNP. In vitro cell adhesion assay and qRT-PCR were performed to analyze the expression of genes involved in cardiomyogenesis, cell adhesion and angiogenesis...
October 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27355149/long-term-outcome-of-intra-myocardial-injection-of-autologous-bone-marrow-mononuclear-cells-combined-with-isolated-coronary-artery-bypass-grafting-for-patients-with-chronic-ischemic-heart-failure
#9
Rong Wang, Lin Zhang, Yao Wang, Zhiyun Gong, Cangsong Xiao, Yang Wu, Chonglei Ren, Nan Cheng, Changqing Gao
OBJECTIVE: This study aimed to investigate whether intra-myocardial injection of autologous bone marrow mononuclear cells (aBMMNCs) into peri-scarred myocardium during coronary artery bypass grafting (CABG) improved the long-term outcome compared with CABG alone. METHODS: From April 2011 to December 2012, 33 patients with chronic ischemic heart failure were randomly assigned to undergo CABG (control group) or CABG combined with intra-myocardial injection of aBMMNCs (treatment group)...
2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/27341741/challenges-to-success-in-heart-failure-cardiac-cell-therapies-in-patients-with-heart-diseases
#10
Hidemasa Oh, Hiroshi Ito, Shunji Sano
Heart failure remains the leading cause of death worldwide, and is a burgeoning problem in public health due to the limited capacity of postnatal hearts to self-renew. The pathophysiological changes in injured hearts can sometimes be manifested as scar formation or myocardial degradation, rather than supplemental muscle regeneration to replenish lost tissue during the healing processes. Stem cell therapies have been investigated as a possible treatment approach for children and adults with potentially fatal cardiovascular disease that does not respond to current medical therapies...
June 21, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27307306/reconstruction-of-postburn-full-facial-deformities-with-an-integrated-method
#11
Qing Feng Li, Tao Zan, Haizhou Li, Bin Gu, Kai Liu, Feng Xie, Yun Xie, Tanja Herrler, Mathias Tremp, Shuangbai Zhou, Xiaolu Huang, Hainan Zhu
BACKGROUND: The face is one of the most important regions of the human body and contains complicated and delicate features that define the identity of a person. Treatment for extensive facial deformities requires resurfacing of the extensive skin defects and restoring the missing features. To date, it remains a major challenge to the reconstructive surgeons. METHODS: The authors reviewed their patients of Type III and Type IV facial deformities to introduce an integrated method for total facial reconstruction...
July 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27267068/effect-of-bone-marrow-derived-mononuclear-cell-treatment-early-or-late-after-acute-myocardial-infarction-twelve-months-cmr-and-long-term-clinical-results
#12
Daniel Sürder, Robert Manka, Tiziano Moccetti, Viviana Lo Cicero, Maximilian Y Emmert, Catherine Klersy, Sabrina Soncin, Lucia Turchetto, Marina Radrizzani, Michel Zuber, Stephan Windecker, Aris Moschovitis, Ines Bühler, Sebastian Kozerke, Paul Erne, Thomas F Lüscher, Roberto Corti
RATIONALE: Intracoronary delivery of autologous bone marrow-derived mononuclear cells (BM-MNC) may improve remodeling of the left ventricle (LV) after acute myocardial infarction (AMI). OBJECTIVE: To demonstrate long-term efficacy of BM-MNC treatment after AMI. METHODS AND RESULTS: In a multicenter study, we randomized 200 patients with large AMI in a 1:1:1 pattern into an open-labeled control and 2 BM-MNC treatment groups. In the BM-MNC groups, cells were either administered 5 to 7 days (early) or 3 to 4 weeks (late) after AMI...
July 22, 2016: Circulation Research
https://www.readbyqxmd.com/read/27254663/intramyocardial-implantation-of-differentiated-rat-bone-marrow-mesenchymal-stem-cells-enhanced-by-tgf-%C3%AE-1-improves-cardiac-function-in-heart-failure-rats
#13
Y Lv, B Liu, H P Wang, L Zhang
The present study tested the hypotheses that i) transforming growth factor beta 1 (TGF-β1) enhances differentiation of rat bone marrow mesenchymal stem cells (MSCs) towards the cardiomyogenic phenotype and ii) intramyocardial implantation of the TGF-β1-treated MSCs improves cardiac function in heart failure rats. MSCs were treated with different concentrations of TGF-β1 for 72 h, and then morphological characteristics, surface antigens and mRNA expression of several transcription factors were assessed. Intramyocardial implantation of these TGF-β1-treated MSCs to infarcted heart was also investigated...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27220939/advances-in-stem-cell-therapy-for-cardiovascular-disease-review
#14
Rongrong Sun, Xianchi Li, Min Liu, Yi Zeng, Shuang Chen, Peying Zhang
Cardiovascular disease constitutes the primary cause of mortality and morbidity worldwide, and represents a group of disorders associated with the loss of cardiac function. Despite considerable advances in the understanding of the pathologic mechanisms of the disease, the majority of the currently available therapies remain at best palliative, since the problem of cardiac tissue loss has not yet been addressed. Indeed, few therapeutic approaches offer direct tissue repair and regeneration, whereas the majority of treatment options aim to limit scar formation and adverse remodeling, while improving myocardial function...
July 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27211019/bone-marrow-derived-mesenchymal-stem-cells-inhibit-the-proliferative-and-profibrotic-phenotype-of-hypertrophic-scar-fibroblasts-and-keloid-fibroblasts-through-paracrine-signaling
#15
Fengjun Fang, Ru-Lin Huang, Yongchao Zheng, Ming Liu, Ran Huo
BACKGROUND: Hypertrophic scars and keloids, characterized by over-proliferation of fibroblasts and aberrant formation of the extracellular matrix (ECM), are considered fibrotic diseases. Accumulating evidence indicates that mesenchymal stem cells (MSCs) promote scar-free wound healing and inhibit fibrotic tissue formation, making them a potentially effective therapeutic treatment for hypertrophic scars and keloids. OBJECTIVE: To investigate the paracrine effects of bone marrow derived MSCs (BMSCs) on the biological behavior of hypertrophic scar fibroblasts (HSFs) and keloid fibroblasts (KFs)...
August 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27102896/experimental-induction-of-reparative-morphogenesis-and-adaptive-reserves-in-the-ischemic-myocardium-using-multipotent-mesenchymal-bone-marrow-derived-stem-cells
#16
V Yu Mykhaylichenko, A V Kubyshkin, S A Samarin, I I Fomochkina, L V Anisimova
INTRODUCTION: Current experimental research has proven the efficacy of transplantation bone marrow-derived mesenchymal stem cells (MSC) in the treatment of myocardial infarction (MI). The one of the main purposes of research was to evaluate the comparative data of the MSC transplantation with (5-azacytidine) and without commitment and to assess the post transplantation effects. METHODS: The efficiency of intravenous cardiomyoplasty by infusion of MSC was evaluated in female Wistar-Kyoto rats with myocardial infarction model using echocardiography, morphological study, morphometry, immunohistostaining, data from in situ hybridization, and by measurement of blood serum levels of nitric oxide, endothelin-1, vascular endothelial growth factor (VEGF), and fibroblast growth factor 2 (FGF2)...
June 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/26901787/intramyocardial-transplantation-of-mesenchymal-stromal-cells-for-chronic-myocardial-ischemia-and-impaired-left-ventricular-function-results-of-the-mesami-1-pilot-trial
#17
D Guijarro, M Lebrin, O Lairez, P Bourin, N Piriou, J Pozzo, G Lande, M Berry, T Le Tourneau, D Cussac, L Sensebe, F Gross, G Lamirault, A Huynh, A Manrique, J B Ruidavet, M Elbaz, J N Trochu, A Parini, S Kramer, M Galinier, P Lemarchand, J Roncalli
BACKGROUND: The MESAMI 1 trial was a bicentric pilot study designed to test the feasibility and safety of intramyocardially injected autologous bone marrow-derived mesenchymal stromal cells (MSCs) for the treatment of ischemic cardiomyopathy. METHODS AND RESULTS: The study included 10 patients with chronic myocardial ischemia, left ventricular (LV) ejection fractions (EFs) of ≤35%, and reversible perfusion defects who were on stable optimal medical therapy and were not candidates for revascularization...
April 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26797822/transfer-of-mesenchymal-stem-cells-and-cyclosporine-a-on-alkali-injured-rabbit-cornea-using-nanofiber-scaffolds-strongly-reduces-corneal-neovascularization-and-scar-formation
#18
Cestmir Cejka, Jitka Cejkova, Peter Trosan, Alena Zajicova, Eva Sykova, Vladimir Holan
The aim of this study was to examine whether nanofiber scaffolds seeded with rabbit bone marrow mesenchymal stem cells (MSCs nanofibers) transferred onto the damaged corneal surface and covered with cyclosporine A (CsA)-loaded nanofiber scaffolds (CsA nanofibers) enable healing of the rabbit cornea injured with 1N NaOH. The healing of damaged corneas was examined morphologically, immunohistochemically and biochemically on day 24 after the injury. Compared to untreated injured corneas, where corneal ulceration or large corneal thinning or even perforation were developed, injured corneas treated with drug free nanofibers healed without profound disturbances in a majority of cases, although with fibrosis and scar formation...
September 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/26631056/-congenital-erythropoietic-porphyria-an-update
#19
C Wenner, N J Neumann, J Frank
BACKGROUND: Congenital erythropoetic porphria is a very rare type of autosomal recessive nonacute porphyria. Homozygous or compound heterozygous mutations in the uroporphyrinogen III consynthase gene cause a marked enzymatic deficiency of uroporphyrinogen III consynthase, the fourth enzyme along the heme biosynthetic pathway. CLINICAL PRESENTATION: Clinically, affected patients are characterized by a moderate to severe photosensitivity. Starting early in infancy, they develop blisters, erosions, and exulcerations in sun-exposed areas of the body, often resulting in scar formation and mutilation...
March 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/26574556/injection-of-human-cord-blood-cells-with-hyaluronan-improves-postinfarction-cardiac-repair-in-pigs
#20
Ming-Yao Chang, Tzu-Ting Huang, Chien-Hsi Chen, Bill Cheng, Shiaw-Min Hwang, Patrick C H Hsieh
UNLABELLED: Recent clinical trials using autologous bone marrow or peripheral blood cells to treat myocardial infarction (MI) show controversial results, although the treatment has a good safety profile. These discrepancies are likely caused by factors such as aging, systemic inflammation, and cell processing procedures, all of which might impair the regenerative capability of the cells used. Here, we tested whether injection of human cord blood mononuclear cells (CB-MNCs) combined with hyaluronan (HA) hydrogel improves cell therapy efficacy in a pig MI model...
January 2016: Stem Cells Translational Medicine
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