keyword
https://read.qxmd.com/read/38490532/effects-of-prune-dried-plum-supplementation-on-cardiometabolic-health-in-postmenopausal-women-an-ancillary-analysis-of-a-12-month-randomized-controlled-trial-the-prune-study
#1
JOURNAL ARTICLE
Janhavi J Damani, Connie J Rogers, Hang Lee, Nicole C A Strock, Kristen J Koltun, Nancy I Williams, Connie Weaver, Mario G Ferruzzi, Cindy H Nakatsu, Mary Jane De Souza
BACKGROUND: Estrogen withdrawal during menopause is associated with an unfavorable cardiometabolic profile. Prunes (dried plums) represent an emerging functional food and have been previously demonstrated to improve bone health. However, our understanding of the effects of daily prune intake on cardiometabolic risk factors in postmenopausal women is limited. OBJECTIVE: We conducted an ancillary investigation of a randomized controlled trial (RCT), The Prune Study, to evaluate the effect of 12-month prune supplementation on cardiometabolic health markers in postmenopausal women...
March 13, 2024: Journal of Nutrition
https://read.qxmd.com/read/38403809/cumulative-incidence-of-and-risk-factors-for-bcg-infection-after-adjuvant-bcg-instillations
#2
JOURNAL ARTICLE
Lars Holmberg, Sten Skogmar, Hans Garmo, Oskar Hagberg, Christel Häggström, Truls Gårdmark, Viveka Ströck, Firas Aljabery, Staffan Jahnson, Abolfazl Hosseini, Tomas Jerlström, Amir Sherif, Karin Söderkvist, Anders Ullén, Per-Uno Malmström, Fredrik Liedberg
OBJECTIVES: To investigate the cumulative incidence proportion of disseminated or local Bacillus Calmette-Guérin (BCG) infections after adjuvant BCG instillations in patients with non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: We analysed the timing and occurrence of BCG infections and absolute and relative risk in relation to patient characteristics available in the Swedish nationwide database 'BladderBaSe 2.0'. The cumulative incidence proportion of a BCG infection was indicated by a reported diagnosis of tuberculosis (TB) in the patient registry or filing a prescription for tuberculostatic drugs...
February 25, 2024: BJU International
https://read.qxmd.com/read/38371208/diagnostic-value-of-repeated-comprehensive-investigation-with-ct-urography-and-cystoscopy-for-recurrent-macroscopic-haematuria
#3
JOURNAL ARTICLE
Suleiman Abuhasanein, Vanessa Chaves, Ali Moustafa Mohsen, Jasmine Al-Haddad, Merete Sunila, Viveka Ströck, Tomas Jerlström, Fredrik Liedberg, Jesper Swärd, Truls Gårdmark, Staffan Jahnson, Henrik Kjölhede
OBJECTIVES: To perform a descriptive analysis of a series of patients with recurrent macroscopic haematuria after a primary standard evaluation including computed tomography urography (CTU) and cystoscopy negative for urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC) and to identify potential factors associated with occurrence of recurrent macroscopic haematuria. METHODS: All patients older than 50 years who underwent urological investigation for macroscopic haematuria with both cystoscopy and CTU 2015-2017 were retrospectively reviewed...
March 2024: BJUI compass
https://read.qxmd.com/read/38349471/prunes-preserve-cortical-density-and-estimated-strength-of-the-tibia-in-a-12-month-randomized-controlled-trial-in-postmenopausal-women-the-prune-study
#4
JOURNAL ARTICLE
Kristen J Koltun, Nicole C A Strock, Connie Weaver, Hang Lee, Nancy I Williams, Connie J Rogers, Janhavi Damani, Mario G Ferruzzi, Cindy H Nakatsu, Mary Jane De Souza
UNLABELLED: Non-pharmacological therapies, such as whole-food interventions, are gaining interest as potential approaches to prevent and/or treat low bone mineral density (BMD) in postmenopausal women. Previously, prune consumption preserved two-dimensional BMD at the total hip. Here we demonstrate that prune consumption preserved three-dimensional BMD and estimated strength at the tibia. PURPOSE: Dietary consumption of prunes has favorable impacts on areal bone mineral density (aBMD); however, more research is necessary to understand the influence on volumetric BMD (vBMD), bone geometry, and estimated bone strength...
February 13, 2024: Osteoporosis International
https://read.qxmd.com/read/38343316/-radical-cystectomy-for-bladder-cancer-is-a-complex-procedure
#5
JOURNAL ARTICLE
Fredrik Liedberg, Oskar Hagberg, Firas Aljabery, Victor Falini, Truls Gårdmark, Tomas Jerlstrom, Viveka Strock
Radical cystectomy (RC) for bladder cancer is a complex procedure with an inherent risk of complications and even postoperative mortality. Historically, RC was performed in 44 hospitals in Sweden, which gradually decreased over time, and since a formal regional centralisation of these operations in 2017, cystectomy care is currently provided by nine hospitals. In the Swedish national urinary bladder cancer register (SNRUBC), complications after RC has been registered with high coverage since 2012, with data presented in an interactive online data resource (RODRET)...
January 31, 2024: Läkartidningen
https://read.qxmd.com/read/38226846/diagnostic-pathways-and-treatment-strategies-in-upper-tract-urothelial-carcinoma-in-sweden-between-2015-and-2021-a-population-based-survey
#6
JOURNAL ARTICLE
Fredrik Liedberg, Oskar Hagberg, Firas Aljabery, Truls Gårdmark, Staffan Jahnson, Tomas Jerlström, Viveka Ströck, Karin Söderkvist, Anders Ullén, Johannes Bobjer
OBJECTIVE: To report national data on diagnostics and treatment of upper tract urothelial carcinoma (UTUC) from the Swedish National Registry of Urinary Bladder Cancer (SNRUBC). PATIENTS AND METHODS: Data from 2015 to 2021 were retrieved, and descriptive analyses were performed regarding incidence, diagnostic modalities, preoperative tumor staging, quality indicators for treatment including the use of standardized care pathways (SCP) and multidisciplinary tumor boards (MDTB)...
January 16, 2024: Scandinavian Journal of Urology
https://read.qxmd.com/read/38118170/unravelling-the-mechanism-of-elastin-like-polypeptide-enzyme-fusion-stabilization-in-organic-solvents
#7
JOURNAL ARTICLE
Saloni Darji, Aayush Aayush, Kiera M Estes, Jocie D Strock, David H Thompson
Elastin-like polypeptides (ELP) are a class of materials that are widely used as purification tags and in potential therapeutic applications. We have used the hydrophobic nature of ELP to extract them into organic solvents and precipitate them to obtain highly pure materials. Although many different types of ELP have been rapidly purified in this manner, the underlying mechanism for this process and its ability to retain functional proteins within organic phase-rich media has been unclear. A cleavable ELP-Intein construct fused with the enzyme chorismate mutase (ELP-I-Cm2) was used to better understand the organic solvent extraction process for ELP and the factors impacting the retention of enzyme activity...
December 20, 2023: Biomacromolecules
https://read.qxmd.com/read/37984741/prune-consumption-attenuates-pro-inflammatory-cytokine-secretion-and-alters-monocyte-activation-in-postmenopausal-women-secondary-outcome-analysis-of-a-12-month-randomized-controlled-trial-the-prune-study
#8
JOURNAL ARTICLE
Janhavi J Damani, Ester S Oh, Mary Jane De Souza, Nicole C A Strock, Nancy I Williams, Cindy H Nakatsu, Hang Lee, Connie Weaver, Connie J Rogers
BACKGROUND: Pro-inflammatory cytokines are implicated in the pathophysiology of postmenopausal bone loss. Clinical studies demonstrate that prunes prevent bone mineral density loss; however, the mechanism underlying this effect is unknown. OBJECTIVE: We investigated the effect of prune supplementation on immune, inflammatory, and oxidative stress markers. METHODS: A secondary analysis was conducted in the Prune Study, a single-center, parallel-arm, 12-month randomized controlled trial of postmenopausal women (55-75 years old; n=235 recruited; n=183 completed) who were assigned to one of three groups: "no-prune" control, 50g/day and 100g/day prune groups...
November 18, 2023: Journal of Nutrition
https://read.qxmd.com/read/37755802/microplastics-distribution-within-western-arctic-seawater-and-sea-ice
#9
JOURNAL ARTICLE
Alessandra D'Angelo, Nicole Trenholm, Brice Loose, Laura Glastra, Jacob Strock, Jongsun Kim
Microplastic pollution has emerged as a global environmental concern, exhibiting wide distribution within marine ecosystems, including the Arctic Ocean. Limited Arctic microplastic data exist from beached plastics, seabed sediments, floating plastics, and sea ice. However, no studies have examined microplastics in the sea ice of the Canadian Arctic Archipelago and Tallurutiup Imanga National Marine Conservation Area, and few have explored Arctic marginal seas' water column. The majority of the microplastic data originates from the Eurasian Arctic, with limited data available from other regions of the Arctic Ocean...
September 20, 2023: Toxics
https://read.qxmd.com/read/37747157/health-related-quality-of-life-prior-to-and-1-year-after-radical-cystectomy-evaluated-with-fact-g-and-fact-vci-questionnaires
#10
JOURNAL ARTICLE
Anna Karin Lind, Fredrik Liedberg, Firas Aljabery, Mats Bläckberg, Truls Gårdmark, Abofazl Hosseini, Tomas Jerlström, Viveka Ströck, Karin Stenzelius
OBJECTIVE: The aim of this study was to investigate health-related quality of life (HRQoL) before and 1 year after radical cystectomy in relation to age and gender. METHODS: This prospective study involves 112 men and 40 women with bladder cancer treated with radical cystectomy between 2015 and 2018. HRQoL was assessed preoperatively and 1 year post-surgery through Functional Assessment of Cancer Therapy Scale - General (FACT-G) and Functional Assessment of Cancer Therapy Scale - Vanderbilt Cystectomy Index (FACT-VCI) questionnaires...
September 21, 2023: Scandinavian Journal of Urology
https://read.qxmd.com/read/37656082/impact-of-the-covid-19-pandemic-on-oral-health-care-use-in-the-united-states-through-december-2021
#11
JOURNAL ARTICLE
Joseph Dill, Margherita Fontana, Jim Bader, Jeffrey Chaffin, Sheila Strock, George Eckert
BACKGROUND: The purpose of this study was to assess the effects of the COVID-19 pandemic on oral health care provided from July 2020 through December 2021 using national claims data. METHODS: Deidentified quarterly claims from 2017 through 2021 were analyzed (2017-2019 provided prepandemic data). Data were sorted into multiple treatment categories. Analyses compared prepandemic with postpandemic procedure volumes and were stratified according to age groups (0-5 years, 6-18 years, 19-64 years, ≥ 65 years)...
August 30, 2023: Journal of the American Dental Association
https://read.qxmd.com/read/37655651/nectophore-coordination-and-kinematics-by-physonect-siphonophores
#12
JOURNAL ARTICLE
Shirah Strock, John H Costello, Joost Daniels, Kakani Katija, Sean P Colin
Siphonophores are ubiquitous and often highly abundant members of pelagic ecosystems throughout the open ocean. They are unique among animal taxa in that many species use multiple jets for propulsion. Little is known about kinematics of the individual jets produced by nectophores or whether the jets are coordinated during normal swimming behavior. Using remotely operated vehicles and SCUBA, we video recorded the swimming behavior of several physonect species in their natural environment. The pulsed kinematics of the individual nectophores that comprise the siphonophore nectosome were quantified and, based on these kinematics, we examined the coordination of adjacent nectophores...
September 1, 2023: Journal of Experimental Biology
https://read.qxmd.com/read/37632908/the-importance-of-gender-neutral-terminology-in-risk-evaluation-and-mitigation-strategy-programs-a-call-to-action
#13
JOURNAL ARTICLE
Colin Burnette, William Smithy, Daniel Strock, Torunn E Sivesind, Robert Dellavalle
The use of risk evaluation and mitigation strategy (REMS) programs is frequently required for prescriptions with potentially teratogenic effects, especially in the field of dermatology. Among these REMS programs, the most well-known example is isotretinoin, an oral retinoid that uses the iPLEDGE system. iPLEDGE has strict regulations and a lengthy approval process, and until recently, patients were grouped into 3 categories: male, female, or female of reproductive potential. This strict grouping has posed problems in the medical community, especially for gender-diverse individuals where their perceived gender conflates with their assigned grouping causing patient-specific distress...
June 22, 2023: JMIR dermatology
https://read.qxmd.com/read/37616418/isotretinoin-use-in-transmasculine-patients-and-its-implication-on-chest-masculinization-surgery-scoping-review-of-the-literature
#14
REVIEW
Daniel Strock, Torunn E Sivesind, Robert P Dellavalle, Gerhard S Mundinger
BACKGROUND: Acne often worsens in transmasculine patients who are on prolonged testosterone therapy. Isotretinoin is an oral retinoid used in the treatment of severe or refractory cases of acne, but it has the potential to cause delayed wound healing. Transmasculine patients may potentially be prescribed treatment for acne with isotretinoin while also planning to undergo chest masculinization surgery. OBJECTIVE: This scoping review aims to determine whether isotretinoin has a negative impact on postoperative healing in transmasculine patients undergoing chest masculinization surgery...
August 10, 2023: JMIR dermatology
https://read.qxmd.com/read/37562603/dermatology-in-the-urgent-care-setting-a-retrospective-review-of-patients-seen-in-an-urgent-access-dermatology-clinic
#15
JOURNAL ARTICLE
Jennifer A Wintringham, Daniel M Strock, Kala Perkins-Holtsclaw, Robert J Smith
No abstract text is available yet for this article.
August 8, 2023: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/37549772/characterization-of-allosteric-modulators-that-disrupt-androgen-receptor-co-activator-protein-protein-interactions-to-alter-transactivation-drug-leads-for-metastatic-castration-resistant-prostate-cancer
#16
JOURNAL ARTICLE
Ashley T Fancher, Yun Hua, David A Close, Wei Xu, Lee A McDermott, Christopher J Strock, Ulises Santiago, Carlos J Camacho, Paul A Johnston
Three series of compounds were prioritized from a high content screening campaign that identified molecules that blocked dihydrotestosterone (DHT) induced formation of Androgen Receptor (AR) protein-protein interactions (PPIs) with the Transcriptional Intermediary Factor 2 (TIF2) coactivator and also disrupted preformed AR-TIF2 PPI complexes; the hydrobenzo-oxazepins (S1), thiadiazol-5-piperidine-carboxamides (S2), and phenyl-methyl-indoles (S3). Compounds from these series inhibited AR PPIs with TIF2 and SRC-1, another p160 coactivator, in mammalian 2-hybrid assays and blocked transcriptional activation in reporter assays driven by full length AR or AR-V7 splice variants...
August 6, 2023: SLAS Discovery
https://read.qxmd.com/read/37463962/rufy3-regulates-endolysosomes-perinuclear-positioning-antigen-presentation-and-migration-in-activated-phagocytes
#17
JOURNAL ARTICLE
Rémy Char, Zhuangzhuang Liu, Cédric Jacqueline, Marion Davieau, Maria-Graciela Delgado, Clara Soufflet, Mathieu Fallet, Lionel Chasson, Raphael Chapuy, Voahirana Camosseto, Eva Strock, Rejane Rua, Catarina R Almeida, Bing Su, Ana-Maria Lennon-Duménil, Beatrice Nal, Antoine Roquilly, Yinming Liang, Stéphane Méresse, Evelina Gatti, Philippe Pierre
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 (RUFY3) exists as two alternative isoforms distinguishable by the presence of a C-terminal FYVE domain and by their affinity for phosphatidylinositol 3-phosphate on endosomal membranes. The FYVE domain-bearing isoform (iRUFY3) is preferentially expressed in primary immune cells and up-regulated upon activation by microbes and Interferons...
July 18, 2023: Nature Communications
https://read.qxmd.com/read/37386013/learning-induced-reorganization-of-number-neurons-and-emergence-of-numerical-representations-in-a-biologically-inspired-neural-network
#18
JOURNAL ARTICLE
Percy K Mistry, Anthony Strock, Ruizhe Liu, Griffin Young, Vinod Menon
Number sense, the ability to decipher quantity, forms the foundation for mathematical cognition. How number sense emerges with learning is, however, not known. Here we use a biologically-inspired neural architecture comprising cortical layers V1, V2, V3, and intraparietal sulcus (IPS) to investigate how neural representations change with numerosity training. Learning dramatically reorganized neuronal tuning properties at both the single unit and population levels, resulting in the emergence of sharply-tuned representations of numerosity in the IPS layer...
June 29, 2023: Nature Communications
https://read.qxmd.com/read/36947969/12-months-of-increased-dietary-intake-does-not-exacerbate-disordered-eating-related-attitudes-stress-or-depressive-symptoms-in-women-with-exercise-associated-menstrual-disturbances-the-refuel-randomized-controlled-trial
#19
JOURNAL ARTICLE
Nicole C A Strock, Mary Jane De Souza, Rebecca J Mallinson, Marion Olmsted, Heather C M Allaway, Emma O'Donnell, Franziska Plessow, Nancy I Williams
UNLABELLED: Disordered eating-related attitudes are a leading cause of energy deficiency and menstrual disturbances in exercising women. Although treatment recommendations include psychological counseling with increases in dietary intake, a key concern is whether increased dietary intake may exacerbate negative eating behaviors. OBJECTIVE: To determine the effects of a 12-month nutritional intervention on eating-related attitudes and psychological characteristics in exercising women with oligomenorrhea/amenorrhea (Oligo/Amen)...
March 8, 2023: Psychoneuroendocrinology
https://read.qxmd.com/read/36814438/associations-between-inflammatory-mediators-and-bone-outcomes-in-postmenopausal-women-a-cross-sectional-analysis-of-baseline-data-from-the-prune-study
#20
JOURNAL ARTICLE
Janhavi J Damani, Mary Jane De Souza, Nicole C A Strock, Kristen J Koltun, Nancy I Williams, Connie Weaver, Connie J Rogers
PURPOSE: Hypoestrogenism triggers increased production of inflammatory mediators, which contribute to bone loss during postmenopausal osteoporosis. This study aimed to investigate the association between circulating inflammatory markers and bone outcomes in postmenopausal women. MATERIALS AND METHODS: We conducted a cross-sectional, secondary analysis of baseline data from participants who completed a 12-month randomized controlled trial, The Prune Study (NCT02822378), which included healthy postmenopausal women (n=183, 55-75 years old) with bone mineral density (BMD) T-score between 0...
2023: Journal of Inflammation Research
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