Thibaut Desmettre, Emilie Dehours, Charles-Marc Samama, Suchin Jhundoo, Frédéric Pujeau, Christian Guillaudin, Claudine Hecquart, Pierre Clerson, Jean Charles Crave, Roland Jaussaud
INTRODUCTION: Prothrombin Complex Concentrate (PCC) is a key treatment in the management of bleeding related to Vitamin K antagonists (VKA). This study aimed to evaluate prospectively PCC use in patients with VKA-related bleeding in view of the French guidelines published in 2008. METHODS: All consecutive patients with VKA-related bleeding treated with a 4-factor PCC (Octaplex®) were selected in 33 French hospitals. Collected data included demographics, site and severity of bleeding, modalities of PCC administration, International Normalized Ratio (INR) values before and after PCC administration, outcomes and survival rate 15 days after infusion...
October 4, 2012: Critical Care: the Official Journal of the Critical Care Forum