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https://www.readbyqxmd.com/read/28529266/preoperative-biliary-drainage-versus-direct-surgery-for-perihilar-cholangiocarcinoma-a-retrospective-study-at-a-single-center
#1
Yulong Cai, Qi Tang, Xianze Xiong, Fuyu Li, Hui Ye, Peipei Song, Nansheng Cheng
Perihilar cholangiocarcinoma (pCC, also known as a Klatskin tumor) is the most common type of cholangiocarcinoma (CC). Preoperative biliary drainage (PBD) is indicated for pCC patients with acute cholangitis or patients who need portal vein embolization (PVE). However, the routine performance of PBD in other patients with pCC is still controversial. The current study retrospectively examined patients with pCC who did not undergo PVE and who did not have cholangitis who were seen at this Hospital to assess the advantages and disadvantages of PBD...
May 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28529121/patient-centred-care-and-shared-decision-making-in-chile-rising-momentum-for-progress-and-implementation-in-clinical-practice
#2
Paulina Bravo, Angelina Dois, Báltica Cabieses, Claudia Bustamante, Solange Campos, Dawn Stacey
The Chilean legislation establishes that patients have rights and responsibilities in regards to their healthcare. This is an important statement as it declares that people must be informed and become actively involved in their care; meanwhile, the health system needs to coordinate the provision of personalised and effective services. Although patient-centred care (PCC) and shared decision-making (SDM) are relatively new concepts in Chile, the country is experiencing an interesting political momentum to create more interventions to achieve PCC and SDM and explore clinical implementation...
May 18, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28527322/arsenic-biotransformation-by-a-cyanobacterium-nostoc-sp-pcc-7120
#3
Xi-Mei Xue, Yu Yan, Chan Xiong, Georg Raber, Kevin Francesconi, Ting Pan, Jun Ye, Yong-Guan Zhu
Nostoc sp. PCC 7120 (Nostoc), a typical filamentous cyanobacterium ubiquitous in aquatic system, is recognized as a model organism to study prokaryotic cell differentiation and nitrogen fixation. In this study, Nostoc cells incubated with arsenite (As(III)) for two weeks were extracted with dichloromethane/methanol (DCM/MeOH) and the extract was partitioned between water and DCM. Arsenic species in aqueous and DCM layers were determined using high performance liquid chromatography - inductively coupled plasma mass spectrometer/electrospray tandem mass spectrometry (HPLC-ICPMS/ESIMSMS)...
May 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28525587/assessing-the-psychedelic-after-glow-in-ayahuasca-users-post-acute-neurometabolic-and-functional-connectivity-changes-are-associated-with-enhanced-mindfulness-capacities
#4
Frederic Sampedro, Mario de la Fuente Revenga, Marta Valle, Natalia Roberto, Elisabet Domínguez-Clavé, Matilde Elices, Luís Eduardo Luna, José Alexandre S Crippa, Jaime E C Hallak, Draulio B de Araujo, Pablo Friedlander, Steven A Barker, Enrique Álvarez, Joaquim Soler, Juan C Pascual, Amanda Feilding, Jordi Riba
Background: Ayahuasca is a plant tea containing the psychedelic 5-HT2A agonist N,N-dimethyltryptamine (DMT) and harmala monoamine-oxidase inhibitors. Acute administration leads to neurophysiological modifications in brain regions of the default mode network (DMN), purportedly through a glutamatergic mechanism. Post-acutely, ayahuasca potentiates mindfulness capacities in volunteers, and induces rapid and sustained antidepressant effects in treatment-resistant patients. However, the mechanisms underlying these fast and maintained effects are poorly understood...
May 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28520647/altered-brain-structure-and-function-associated-with-sensory-and-affective-components-of-classic-trigeminal-neuralgia
#5
Yuan Wang, Dong-Yuan Cao, Bethany Remeniuk, Samuel Krimmel, David A Seminowicz, Ming Zhang
Classic trigeminal neuralgia (CTN) is a chronic neuropathic pain state characterized by intense, piercing spasms of the orofacial region, and may be attributable to abnormal pain processing in the central nervous system. Our study investigated neuronal alterations using voxel-based morphometry (VBM), diffuse tensor imaging (DTI), and resting state functional connectivity in 38 CTN patients and 38 matched healthy controls. For VBM analyses, CTN patients displayed gray matter volume (GMV) reductions in the anterior and mid cingulate cortex (ACC and MCC), insula, secondary somatosensory cortex (S2), primary motor cortex (M1), premotor area (PMA), and several regions in the temporal lobe...
May 16, 2017: Pain
https://www.readbyqxmd.com/read/28520412/identification-of-the-ferredoxin-binding-site-of-a-ferredoxin-dependent-cyanobacterial-nitrate-reductase
#6
Anurag P Srivastava, Emily P Hardy, James P Allen, Brian J Vaccaro, Michael K Johnson, David B Knaff
An in silico model for the 1:1 ferredoxin (Fd)/nitrate reductase (NR) complex, using the known structure of Synechocystis sp. PCC 6803 Fd and the in silico model of Synechococcus sp. PCC 7942 NR, is used to map the interaction sites that define the interface between Fd and NR. To test the electrostatic interactions predicted by the model complex, five positively charged NR amino acids Arg43, Arg46, Arg197, Lys201 and Lys614; and a negatively charged amino acid, Glu219, were altered using site-directed mutagenesis and characterized by activity measurements, metal analysis and EPR studies...
May 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28516845/activity-and-functional-properties-of-the-isocitrate-lyase-in-the-cyanobacterium-cyanothece-sp-pcc-7424
#7
Marianne Gründel, Henning Knoop, Ralf Steuer
Cyanobacteria are ubiquitous photoautotrophs that assimilate atmospheric CO2 as their main source of carbon. Several cyanobacteria are known to be facultative heterotrophs that are able to grow on diverse carbon sources. For selected strains, assimilation of organic acids and mixotrophic growth on acetate has been reported for decades. However, evidence for the existence of a functional glyoxylate shunt in cyanobacteria has long been contradictory and unclear. Genes coding for isocitrate lyase (ICL) and malate synthase were recently identified in two strains of the genus Cyanothece, and the existence of the complete glyoxylate shunt was verified in a strain of Chlorogloeopsis fritschii...
May 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28507656/development-of-a-pharmacist-referral-program-in-a-primary-care-clinic-prepare-a-prospective-cross-sectional-study
#8
Arden R Barry
BACKGROUND: Increasing demand for ambulatory health care services has led to the development of primary care multidisciplinary teams that include pharmacists. The objective of this study was to characterize referrals to a pharmacist in a primary care clinic (PCC) based in Chilliwack, British Columbia. METHODS: This prospective cross-sectional study included all patients referred to the PCC pharmacist over 12 months (May 2015 to April 2016). Data regarding the source/reason for referral, patient demographics, medical problems/medications and number/category of identified drug therapy concerns (DTCs) were collected...
May 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28506213/voxel-wise-correlations-between-cognition-and-cerebral-blood-flow-using-arterial-spin-labeled-perfusion-mri-in-patients-with-alzheimer-s-disease-a-cross-sectional-study
#9
Tomohiro Kaneta, Omi Katsuse, Takamasa Hirano, Matsuyoshi Ogawa, Ayako Shihikura-Hino, Keisuke Yoshida, Toshinari Odawara, Yoshio Hirayasu, Tomio Inoue
BACKGROUND: To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer's disease (AD). METHODS: Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD1.5 and PLD2.5, respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28)...
May 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28500030/translating-divergent-environmental-stresses-into-a-common-proteome-response-through-hik33-in-a-model-cyanobacterium
#10
Haitao Ge, Longfa Fang, Xiahe Huang, Jinlong Wang, Weiyang Chen, Ye Liu, Yuanya Zhang, Xiaorong Wang, Wu Xu, Qingfang He, Yingchun Wang
The histidine kinase Hik33 plays important roles in mediating cyanobacterial response to divergent types of abiotic stresses including cold, salt, high light (HL), and osmotic stresses. However, how these functions are regulated by Hik33 remains to be addressed. Using a hik33-deficient strain (Δhik33) of Synechocystis sp. PCC 6803 (Synechocystis) and quantitative proteomics, we found that Hik33 depletion induces differential protein expression highly similar to that induced by divergent types of stresses. This typically includes downregulation of proteins in photosynthesis and carbon assimilation that are necessary for cell propagation, and upregulation of heat shock proteins, chaperons, and proteases that are important for cell survival...
May 12, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28499032/development-of-a-new-tool-for-systematic-observation-of-nursing-home-resident-and-staff-engagement-and-relationship
#11
A Lynn Snow, M Lindsey Jacobs, Jennifer A Palmer, Patricia A Parmelee, Rebecca S Allen, Nancy J Wewiorski, Michelle M Hilgeman, Latrice D Vinson, Dan R Berlowitz, Anne D Halli-Tierney, Christine W Hartmann
Purpose of Study: To develop a structured observational tool, the Resident-centered Assessment of Interactions with Staff and Engagement tool (RAISE), to measure 2 critical, multi-faceted, organizational-level aspects of person-centered care (PCC) in nursing homes: (a) resident engagement and (b) the quality and frequency of staff-resident interactions. Design and Methods: In this multi-method psychometric development study, we conducted (a) 120 hr of ethnographic observations in one nursing home and (b) a targeted literature review to enable construct development...
May 11, 2017: Gerontologist
https://www.readbyqxmd.com/read/28498724/phonological-patterns-templates-in-5p-deletion-syndrome
#12
Nina Gram Garmann, Kristian Emil Kristoffersen, Hanne Gram Simonsen
Whole word phonological patterns (templates) in utterances produced by children with 5p deletion syndrome are analysed, addressing four questions: (1) Are children with 5p deletion syndrome able to generalise over words? (2) How does the template score of children with 5p deletion syndrome relate to those of typically developing children and of the target language? (3) How do the template scores relate to other phonological measures, PCC and consonant variegation? (4) What can the relationship between template scores and phonological measures tell us about templates? Children with 5p deletion syndrome are able to generalise over words, some to a target like extent, others generalise more than expected for their age...
May 12, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28494182/fabg-can-function-as-phab-for-poly-3-hydroxybutyrate-biosynthesis-in-photosynthetic-cyanobacteria-synechocystis-sp-pcc-6803
#13
Haowei Zhang, Yinghui Liu, Changhong Yao, Xupeng Cao, Jing Tian, Song Xue
The production of poly-3-hydroxybutyrate (PHB) by photosynthetic cyanobacteria is a potentially sustainable production method for the biodegradable plastics industry. β-Ketoacyl-ACP reductase (FabG), from the photosynthetic cyanobacterium Synechocystis sp. PCC 6803 (SpFabG), is the first NADPH-dependent reductase in the fatty acid biosynthesis pathway. Its structure is similar to that of acetoacetyl-CoA reductase (SpPhaB), which is critical for PHB synthesis and can replace SpPhaB for acetoacetyl-CoA reduction in vitro...
May 11, 2017: Bioengineered
https://www.readbyqxmd.com/read/28490471/analysis-of-prognostic-values-of-various-pet-metrics-in-preoperative-fdg-pet-for-early-stage-bronchial-carcinoma-for-progression-free-and-overall-survival-significantly-increased-glycolysis-is-a-predictive-factor
#14
Seraina Steiger, Michael Arvanitakis, Beate Sick, Walter Weder, Sven Hillinger, Irene A Burger
Purpose: To assess various volume based PET quantification metrics including: metabolic tumor volume (MTV) and total lesion glycolysis (TLG) with different thresholds as well as background activity based PET metrics (Background Subtracted Lesion activity (BSL) and Volume (BSV)) as prognostic markers for progression free and overall survival (PFS, OS) in early stage I and II non-small cell lung cancer (NSCLC) after resection. Patients and Methods: 133 patients received an adequate FDG PET/CT scan prior to surgery between January 2003 and December 2010...
May 10, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28489343/rearranged-biosynthetic-gene-cluster-and-synthesis-of-hassallidin-e-in-planktothrix-serta-pcc-8927
#15
Claire Pancrace, Jouni Jokela, Nathalie Sassoon, Christelle Ganneau, Marie Desnos-Ollivier, Matti Wahlsten, Anu Humisto, Alexandra Calteau, Sylvie Bay, David P Fewer, Kaarina Sivonen, Muriel Gugger
Cyanobacteria produce a wide range of natural products with antifungal bioactivity. The cyclic glycosylated lipopeptides of the hassallidin family have potent antifungal activity and display a great degree of chemical diversity. Here we report the discovery of a hassallidin biosynthetic gene cluster from the filamentous cyanobacterium Planktothrix serta PCC 8927. The hassallidin gene cluster showed heavy rearrangement and marks of genomic plasticity. Nucleotide bias, differences in GC content and phylogenetic incongruence suggested the acquisition of the hassallidin biosynthetic gene cluster in Planktothrix serta PCC 8927 by horizontal gene transfer...
May 10, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28488106/treatment-evaluation-of-flow-limiting-stenoses-of-the-superficial-femoral-and-popliteal-artery-by-parametric-color-coding-analysis-of-digital-subtraction-angiography-series
#16
Michael Kostrzewa, Kerim Kara, Lothar Pilz, Hannelore Mueller-Muertz, Nils Rathmann, Stefan O Schoenberg, Steffen J Diehl
PURPOSE: To evaluate the hemodynamic effect of percutaneous transluminal intervention (PTI) on stenosis of the superficial femoral (SFA) and popliteal arteries (PA) using time-density curves (TDCs) derived from digital subtraction angiography (DSA) series in correlation with ultrasound peak systolic velocity ratio (PSVR) and ankle brachial index (ABI). MATERIALS AND METHODS: DSA series of SFA or PA of patients with symptomatic peripheral arterial occlusive disease was obtained with a flat-panel angiography system with intention-to-treat...
May 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28486837/distinct-effects-of-reminding-mortality-and-physical-pain-on-the-default-mode-activity-and-activity-underlying-self-reflection
#17
Zhenhao Shi, Shihui Han
Behavioral research suggests that reminding both mortality and negative affect influences self-related thoughts. Using functional MRI, we tested the hypothesis that reminders of mortality and physical pain decrease brain activity underlying self-related thoughts. Three groups of adults underwent priming procedures during which they answered questions pertaining to mortality, physical pain, or leisure time, respectively. Before and after priming, participants performed personality trait judgments on oneself or a celebrity, identified the font of words, or passively viewed a fixation...
May 9, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28485419/crosstalk-of-two-component-signal-transduction-systems-in-regulating-central-carbohydrate-and-energy-metabolism-during-autotrophic-and-photomixotrophic-growth-of-synechocystis-sp-pcc-6803
#18
Guangsheng Pei, Xiangfeng Niu, Yuqing Zhou, Lei Chen, Weiwen Zhang
Unicellular model cyanobacterium Synechocystis sp. PCC 6803 has received considerable attention as a sustainable energy resource because of its photosynthetic machinery. However, two-component signal transduction systems (TCSTSs) in regulating central carbohydrate and energy metabolism of cyanobacteria are still poorly understood due to their diversity and functional complication. In this study, by comparing the growth of knockout mutants of 44 response regulators (RRs) of TCSTSs in Synechocystis, several RR mutants demonstrating differential growth patterns were identified under auto- or photomixotrophic conditions...
May 22, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28484419/altered-functional-connectivity-of-striatal-subregions-in-patients-with-multiple-sclerosis
#19
Fangyuan Cui, Li Zhou, Zengjian Wang, Courtney Lang, Joel Park, Zhongjian Tan, Yao Yu, Chunyan Sun, Ying Gao, Jian Kong
Abnormal corticostriatal resting-state functional connectivity (rsFC) has been implicated in the neuropathology of multiple sclerosis. The striatum, a component of the basal ganglia, is involved in diverse functions including movement, cognition, emotion, and limbic information processing. However, the brain circuits of the striatal subregions contributing to the changes in rsFC in relapsing-remitting multiple sclerosis (RRMS) patients remain unknown. We used six subdivisions of the striatum in each hemisphere as seeds to investigate the rsFC of striatal subregions between RRMS patients and matched healthy controls (HCs)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28484402/to-resolve-or-not-to-resolve-that-is-the-question-the-dual-path-model-of-incongruity-resolution-and-absurd-verbal-humor-by-fmri
#20
Ru H Dai, Hsueh-Chih Chen, Yu C Chan, Ching-Lin Wu, Ping Li, Shu L Cho, Jon-Fan Hu
It is well accepted that the humor comprehension processing involves incongruity detection and resolution and then induces a feeling of amusement. However, this three-stage model of humor processing does not apply to absurd humor (so-called nonsense humor). Absurd humor contains an unresolvable incongruity but can still induce a feeling of mirth. In this study, we used functional magnetic resonance imaging (fMRI) to identify the neural mechanisms of absurd humor. Specifically, we aimed to investigate the neural substrates associated with the complete resolution of incongruity resolution humor and partial resolution of absurd humor...
2017: Frontiers in Psychology
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