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https://www.readbyqxmd.com/read/28231563/hypoxia-pathway-mutations-in-pheochromocytomas-and-paragangliomas
#1
Diana Amorim-Pires, Joana Peixoto, Jorge Lima
Pheochromocytomas (PCC) and sympathetic paragangliomas (PGL) are rare neuroendocrine tumors, which derive from chromaffin cells occurring in the adrenal medulla and extra-adrenal sympathetic paraganglia. PCC and PGL are often benign, catecholamine-producing tumors, responsible for a myriad of symptoms that may be potentially hazardous to the patient. In contrast, nonsecreting parasympathetic PGL, derived from chief cells, develop mainly in the head and neck region. Although PCC/PGL are more commonly sporadic tumors, germline mutations are present in up to 40% of the patients, ranking these tumors among those with the highest degree of heritability...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28230575/patients-and-care-partners-perspectives-on-dignity-and-respect-during-acute-care-hospitalization
#2
Priscilla K Gazarian, Constance R C Morrison, Lisa Soleymani Lehmann, Orly Tamir, David W Bates, Ronen Rozenblum
BACKGROUND: Delivering patient-centered care (PCC) is essential to our healthcare system. Patient dignity and respect are foundational elements of PCC. Understanding patients' and their care partner's perspectives on the meaning of dignity and respect within a clinical care environment is critical to achieving our goal of PCC. OBJECTIVE: The aim of the study was to understand how patients and their care partners define, describe, and experience dignity and respect during hospitalization...
February 22, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28220586/prevalence-of-anxiety-and-depressive-symptoms-and-their-association-with-pelvic-floor-dysfunctions-a-cross-sectional-cohort-study-at-a-pelvic-care-centre
#3
Desiree Vrijens, Bary Berghmans, Fred Nieman, Jim van Os, Gommert van Koeveringe, Carsten Leue
AIMS: Pelvic floor dysfunctions (PFDs), like voiding complaints, urinary and fecal incontinence, and prolapse, are prevalent and associated with decrease in quality of life. PFDs are often complex and multifactorial in origin showing interrelationships between different PFD and with affective conditions. The primary aim of this study is to describe the prevalence of affective complaints in a cohort of Pelvic Care Centre (PCC) patients. The secondary aim is to describe associations between PFDs and depression or anxiety...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28219460/collaborative-care-model-in-mental-health-scope-and-experiences-after-three-years-of-activity-in-mexico-city
#4
Valerio Villamil-Salcedo, Blanca E Vargas-Terrez, Adriana Díaz-Anzaldúa
: Aim The aim of this study was to evaluate the experience of the Collaborative Care model with general practitioners (GPs) for diagnosis and treatment of depression and anxiety disorders in primary care centers (PCC). BACKGROUND: For many years, different ways to address mental health problems in primary care settings have been evaluated. However, there is still debate over how to treat psychiatric conditions in such a context. METHOD: A cross-sectional design was used...
February 21, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28218556/scandcleft-randomised-trials-of-primary-surgery-for-unilateral-cleft-lip-and-palate-5-speech-outcomes-in-5-year-olds-consonant-proficiency-and-errors
#5
Elisabeth Willadsen, Anette Lohmander, Christina Persson, Inger Lundeborg, Suvi Alaluusua, Ragnhild Aukner, Anja Bau, Maria Boers, Melanie Bowden, Julie Davies, Berit Emborg, Christina Havstam, Christine Hayden, Gunilla Henningsson, Anders Holmefjord, Elina Hölttä, Mia Kisling-Møller, Lillian Kjøll, Maria Lundberg, Eilish McAleer, Jill Nyberg, Marjukka Paaso, Nina Helen Pedersen, Therese Rasmussen, Sigvor Reisæter, Helene Søgaard Andersen, Antje Schöps, Inger-Beate Tørdal, Gunvor Semb
BACKGROUND AND AIM: Normal articulation before school start is a main objective in cleft palate treatment. The aim was to investigate if differences exist in consonant proficiency at age 5 years between children with unilateral cleft lip and palate (UCLP) randomised to different surgical protocols for primary palatal repair. A secondary aim was to estimate burden of care in terms of received additional secondary surgeries and speech therapy. DESIGN: Three parallel group, randomised clinical trials were undertaken as an international multicentre study by 10 cleft teams in five countries: Denmark, Finland, Norway, Sweden, and the UK...
February 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28216046/inactivation-of-iron-sulfur-cluster-biogenesis-regulator-sufr-in-synechocystis-sp-pcc-6803-induces-unique-iron-dependent-protein-level-responses
#6
Linda Vuorijoki, Arjun Tiwari, Pauli Kallio, Eva-Mari Aro
BACKGROUND: Iron-sulfur (Fe-S) clusters are protein-bound cofactors associated with cellular electron transport and redox sensing, with multiple specific functions in oxygen-evolving photosynthetic cyanobacteria. The aim here was to elucidate protein-level effects of the transcriptional repressor SufR involved in the regulation of Fe-S cluster biogenesis in the cyanobacterium Synechocystis sp. PCC 6803. METHODS: The approach was to quantitate 94 pre-selected target proteins associated with various metabolic functions using SRM in Synechocystis...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28215391/childhood-trauma-related-alterations-in-brain-function-during-a-theory-of-mind-task-in-schizophrenia
#7
Yann Quidé, Xin H Ong, Sebastian Mohnke, Knut Schnell, Henrik Walter, Vaughan J Carr, Melissa J Green
Childhood trauma is a risk factor for schizophrenia that affects brain functions associated with higher cognitive processes, including social cognition. Alterations in Theory-of-Mind (ToM), or mentalizing skills, are a hallmark feature of schizophrenia, and are also evident in individuals exposed to childhood trauma. However, the impact of childhood trauma exposure on brain function during social cognition in schizophrenia remains unclear. We thus examined the association between childhood trauma and brain function during the performance of a ToM task in 47 patients diagnosed with schizophrenia or schizoaffective disorder...
February 15, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28214167/psychometric-evaluation-and-design-of-patient-centered-communication-measures-for-cancer-care-settings
#8
Bryce B Reeve, David M Thissen, Carla M Bann, Nicole Mack, Katherine Treiman, Hanna K Sanoff, Nancy Roach, Brooke E Magnus, Jason He, Laura K Wagner, Rebecca Moultrie, Kathryn D Jackson, Courtney Mann, Lauren A McCormack
OBJECTIVE: To evaluate the psychometric properties of questions that assess patient perceptions of patient-provider communication and design measures of patient-centered communication (PCC). METHODS: Participants (adults with colon or rectal cancer living in North Carolina) completed a survey at 2 to 3 months post-diagnosis. The survey included 87 questions in six PCC Functions: Exchanging Information, Fostering Health Relationships, Making Decisions, Responding to Emotions, Enabling Patient Self-Management, and Managing Uncertainty...
February 10, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28208118/validation-of-a-novel-monitoring-system-to-measure-contrast-volume-use-during-invasive-angiography
#9
Anand Prasad, Irma Scholler, Daniel Levin, Gus Banda, Christopher M Mullin, Steven R Bailey
BACKGROUND: Multiple studies have demonstrated the relationship between contrast volume (CV) and the risk of acute kidney injury (AKI). Quantification of total CV is often estimated and therefore may be inaccurate. We describe validation of a novel contrast monitoring system (CMS) (Osprey Medical), which is designed to detect and display injection by injection and total CV use on a monitor system in real time. METHODS: Thirty patients undergoing a coronary or peripheral angiogram were included...
February 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28205364/altered-neural-mechanisms-of-cognitive-control-in-patients-with-primary-progressive-multiple-sclerosis-an-effective-connectivity-study
#10
Ekaterina Dobryakova, Maria Assunta Rocca, Paola Valsasina, John DeLuca, Massimo Filippi
Primary progressive multiple sclerosis (PPMS) leads to physical and cognitive disability. Specifically, cognitive deficits in PPMS have been explained by both grey matter atrophy and white matter lesions. However, existing research still lacks in the understanding of how the brain of a patient with PPMS functions under cognitive control demands. Thus, the aim of the current study was to examine information integration in patients with PPMS using a search-based effective connectivity method. Fourteen patients with PPMS and 22 age- and gender-matched healthy controls (HC) performed the Stroop task, a cognitively demanding interference task that taxes neural resources required for cognitive control and response inhibition...
February 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28197096/resting-state-brain-anomalies-in-type-2-diabetes-a-meta-analysis
#11
REVIEW
Wenqing Xia, Yu-Chen Chen, Jianhua Ma
Resting-state functional magnetic resonance imaging (fMRI) studies have revealed abnormal neural activity in patients with type 2 diabetes mellitus (T2DM). Nonetheless, these findings are heterogeneous and have not been quantitatively reviewed. Thus, we aimed to conduct a meta-analysis that identified consistent results of existing resting-state fMRI studies to determine concordant resting-state neural brain activity alterations in T2DM patients. A systematic search was conducted for resting-state fMRI studies comparing T2DM patients with healthy controls...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28196027/mk2461-a-multitargeted-kinase-inhibitor-suppresses-the-progression-of-pancreatic-cancer-by-disrupting-the-interaction-between-pancreatic-cancer-cells-and-stellate-cells
#12
Koetsu Inoue, Hideo Ohtsuka, Masanori Tachikawa, Fuyuhiko Motoi, Masahiro Shijo, Daisuke Douchi, Shuhei Kawasaki, Kei Kawaguchi, Kunihiro Masuda, Koji Fukase, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Tetsuya Terasaki
OBJECTIVES: Platelet-derived growth factor receptor beta (PDGFRβ) and hepatocyte growth factor receptor (MET) expressed on pancreatic stellate cells (PSCs) are suggested as important components modulating the interactions between pancreatic cancer cells (PCCs) and PSCs. The objective of this study is to clarify the effect of MK2461, a multikinase inhibitor targeting MET and PDGFRβ, on the interaction between PCCs and PSCs. METHODS: In this study, we profiled the expression of receptor tyrosine kinases (including PDGFRβ and MET) in pancreatic cancer with quantitative targeted absolute proteomics using liquid chromatography tandem mass spectrometry...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28195018/glottic-closing-force-versus-laryngeal-adductory-pressure-in-the-canine-larynx
#13
Randal C Paniello, Neel K Bhatt
INTRODUCTION: The strength of glottic closure with recurrent laryngeal nerve (RLN) stimulation has been indirectly measured experimentally by determining the squeezing pressure on a balloon inserted between the vocal folds, termed laryngeal adductory pressure (LAP). In this study, we sought to measure glottic closing force (GCF) directly and compare these results to LAP measures obtained with identical stimulation parameters. METHODS: In canines, a method for measuring GCF was developed in which a suture was looped through a lateral thyrotomy hole, around the vocal process and back, then attached to a force gauge...
March 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28192860/amplitude-of-low-frequency-fluctuations-during-resting-state-differentially-predicts-authentic-and-hubristic-pride
#14
Feng Kong, Qiaolin He, Xiqin Liu, Xiayu Chen, Xu Wang, Jingjing Zhao
OBJECTIVE: Pride is an important self-conscious emotion and comprised of two distinct conceptual facets: arrogant, egotistic "hubristic pride", and pro-social, achievement-oriented "authentic pride". However, little is known about the neural basis of two facets of pride. Here we investigated the association between spontaneous brain activity and these two facets of pride in resting state. METHOD: We measured 276 participants on authentic and hubristic pride. The fractional amplitude of low frequency fluctuations (fALFF) was used to identify pride-related regions...
February 13, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28192554/using-patient-centered-care-after-a-prenatal-diagnosis-of-trisomy-18-or-trisomy-13-a-review
#15
Shelly Haug, Mitchell Goldstein, Denise Cummins, Elba Fayard, T Allen Merritt
Importance: Patient-centered care (PCC) has been advocated by the Institute of Medicine to improve health care in the United States. Four concepts of PCC align with clinical ethics principles and are associated with enhanced patient/parent satisfaction. These concepts are dignity and respect, information sharing, participation, and collaboration. The objective of this article is to use the PCC approach as a framework for an extensive literature review evaluating the current status of counseling regarding prenatal diagnosis of trisomy 18 (T18) or trisomy 13 (T13) and to advocate PCC in the care of these infants...
February 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28191640/pathogen-safety-of-a-pasteurized-four-factor-human-prothrombin-complex-concentrate-preparation-using-serial-20n-virus-filtration
#16
Thomas Nowak, Birgit Popp, Albrecht Gröner, Wolfram Schäfer, Uwe Kalina, Karlheinz Enssle, Nathan J Roth
BACKGROUND: Beriplex P/N/Kcentra/Coaplex/Confidex is a four-factor human prothrombin complex concentrate (PCC). Here, we describe the pathogen safety profile and biochemical characteristics of an improved manufacturing process that further enhances the virus safety of Beriplex P/N. STUDY DESIGN AND METHODS: Samples of product intermediates were spiked with test viruses, and prions were evaluated under routine production and robustness conditions of the scale-down version of the commercial manufacturing process for their capacity to inactivate or remove pathogens...
February 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28189105/determination-of-methylmalonyl-coenzyme-a-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-for-measuring-propionyl-coenzyme-a-carboxylase-activity-in-patients-with-propionic-acidemia
#17
Kana Gotoh, Yoko Nakajima, Go Tajima, Yoriko Watanabe, Yuji Hotta, Tomoya Kataoka, Yoshihiro Kawade, Naruji Sugiyama, Tetsuya Ito, Kazunori Kimura, Yasuhiro Maeda
Propionic acidemia (PA) is an inherited metabolic disease caused by low activity of propionyl coenzyme A (CoA) carboxylase (PCC), which metabolizes propionyl-CoA into methylmalonyl-CoA. Although many patients with PA have been identified by tandem mass spectrometry since the test was first included in neonatal mass screening in the 1990s, the disease severity varies. Thus, determining the specific level of PCC activity is considered to be helpful to grasp the severity of PA. We developed a new PCC assay method by the determination of methylmalonyl-CoA, which is formed by an enzyme reaction using peripheral lymphocytes, based on ultra high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)...
February 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28188881/abnormal-regional-activity-and-functional-connectivity-in-resting-state-brain-networks-associated-with-etiology-confirmed-unilateral-pulsatile-tinnitus-in-the-early-stage-of-disease
#18
Han Lv, Pengfei Zhao, Zhaohui Liu, Rui Li, Ling Zhang, Peng Wang, Fei Yan, Liheng Liu, Guopeng Wang, Rong Zeng, Ting Li, Cheng Dong, Shusheng Gong, Zhenchang Wang
Abnormal neural activities can be revealed by resting-state functional magnetic resonance imaging (rs-fMRI) using analyses of the regional activity and functional connectivity (FC) of the networks in the brain. This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus...
February 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28185041/variety-in-excitation-energy-transfer-processes-from-phycobilisomes-to-photosystems-i-and-ii
#19
Yoshifumi Ueno, Shimpei Aikawa, Kyosuke Niwa, Tomoko Abe, Akio Murakami, Akihiko Kondo, Seiji Akimoto
The light-harvesting antennas of oxygenic photosynthetic organisms capture light energy and transfer it to the reaction centers of their photosystems. The light-harvesting antennas of cyanobacteria and red algae, called phycobilisomes (PBSs), supply light energy to both photosystem I (PSI) and photosystem II (PSII). However, the excitation energy transfer processes from PBS to PSI and PSII are not understood in detail. In the present study, the energy transfer processes from PBS to PSs in various cyanobacteria and red algae were examined in vivo by selectively exciting their PSs or PBSs, and measuring the resulting picosecond to nanosecond time-resolved fluorescences...
February 9, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28181142/erratum-to-is-raf1-protein-from-synechocystis-sp-pcc-6803-really-needed-in-the-cyanobacterial-rubisco-assembly-process
#20
Piotr Kolesinski, Malgorzata Rydzy, Andrzej Szczepaniak
No abstract text is available yet for this article.
February 8, 2017: Photosynthesis Research
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