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https://www.readbyqxmd.com/read/28940495/understanding-the-potential-for-patient-engagement-in-electronic-consultation-and-referral-systems-lessons-from-one-safety-net-system
#1
Jacqueline Nwando Olayiwola, Margae Knox, Kate Dubé, Emily Chen-Yuan Lu, Tem Woldeyesus, Iguehi E James, Rachel Willard-Grace, Delphine Tuot
OBJECTIVE: To understand patient, primary care clinician (PCC), and subspecialist perspectives on potential, unexplored roles for patients in electronic consultation and referral (eCR) systems. DATA SOURCES: Primary focus group and survey data collected April-November 2015. Zuckerberg San Francisco General Hospital (ZSFG) is part of an integrated public health delivery system. Its mature eCR system was first implemented in 2005. STUDY DESIGN: This mixed-methods study synthesizes patient, subspecialist, and PCC perspectives through two patient focus groups in English, Spanish, and Cantonese (n = 6); subspecialist focus groups (n = 2); and an electronic survey of all PCCs (n = 222/634, 35 percent response)...
September 20, 2017: Health Services Research
https://www.readbyqxmd.com/read/28939396/novel-therapies-for-angiotensin-converting-enzyme-inhibitor-induced-angioedema-a-systematic-review-of-current-evidence
#2
Heidi M Riha, Bryant B Summers, Jessica V Rivera, Megan A Van Berkel
BACKGROUND: Angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema can occur at any point during therapy and, when severe, can require mechanical ventilation. Standard agents for anaphylactic reactions have limited efficacy for bradykinin-mediated angioedema and, therefore, agents approved for hereditary angioedema are increasingly prescribed for these patients. OBJECTIVE OF THE REVIEW: This systematic review critically evaluates evidence describing the off-label use of fresh frozen plasma (FFP), prothrombin complex concentrate (PCC), complement 1 esterase inhibitor (C1-INH), icatibant, and ecallantide for treatment of ACEI-induced angioedema...
September 19, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28935842/the-paralogs-to-the-c-terminal-domain-of-the-cyanobacterial-ocp-are-carotenoid-donors-to-hcps
#3
Fernando Muzzopappa, Adjélé Wilson, Vinosa Yogarajah, Sandrine Cot, François Perreau, Cédric Montigny, Céline Bourcier de Carbon, Diana Kirilovsky
The photoactive Orange Carotenoid Protein photoprotects cyanobacteria cells by quenching singlet oxygen and excess excitation energy. Its N-terminal domain (NTD) is the active part of the protein and the C-terminal domain (CTD) regulates the activity. Recently, the characteristics of a family of soluble carotenoid-binding proteins (Helical Carotenoid Proteins or HCPs), paralogs of NTD-OCP, were described. Bioinformatics studies also revealed the existence of genes coding for homologs of CTD. Here, we show that the latter genes encode carotenoid proteins (CTDHs)...
September 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28929086/role-of-two-cell-wall-amidases-in-septal-junction-and-nanopore-formation-in-the-multicellular-cyanobacterium-anabaena-sp-pcc-7120
#4
Jan Bornikoel, Alejandro Carrión, Qing Fan, Enrique Flores, Karl Forchhammer, Vicente Mariscal, Conrad W Mullineaux, Rebeca Perez, Nadine Silber, C Peter Wolk, Iris Maldener
Filamentous cyanobacteria have developed a strategy to perform incompatible processes in one filament by differentiating specialized cell types, N2-fixing heterocysts and CO2-fixing, photosynthetic, vegetative cells. These bacteria can be considered true multicellular organisms with cells exchanging metabolites and signaling molecules via septal junctions, involving the SepJ and FraCD proteins. Previously, it was shown that the cell wall lytic N-acetylmuramyl-L-alanine amidase, AmiC2, is essential for cell-cell communication in Nostoc punctiforme...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28925006/evidence-based-source-modeling-of-nociceptive-cortical-responses-a-direct-comparison-of-scalp-and-intracranial-activity-in-humans
#5
Claire Bradley, Hélène Bastuji, Luis Garcia-Larrea
BACKGROUND: Source modeling of EEG traditionally relies on interplay between physiological hypotheses and mathematical estimates. We propose to optimize the process by using evidence gathered from brain imaging and intracortical recordings. METHODS: We recorded laser-evoked potentials in 18 healthy participants, using high-density EEG. Brain sources were modeled during the first second poststimulus, constraining their initial position to regions where nociceptive-related activity has been ascertained by intracranial EEG...
September 18, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28924506/automated-classification-of-tropical-shrub-species-a-hybrid-of-leaf-shape-and-machine-learning-approach
#6
Miraemiliana Murat, Siow-Wee Chang, Arpah Abu, Hwa Jen Yap, Kien-Thai Yong
Plants play a crucial role in foodstuff, medicine, industry, and environmental protection. The skill of recognising plants is very important in some applications, including conservation of endangered species and rehabilitation of lands after mining activities. However, it is a difficult task to identify plant species because it requires specialized knowledge. Developing an automated classification system for plant species is necessary and valuable since it can help specialists as well as the public in identifying plant species easily...
2017: PeerJ
https://www.readbyqxmd.com/read/28920082/is-a-persistent-central-canal-a-risk-factor-for-neurological-injury-in-patients-undergoing-surgical-correction-of-scoliosis
#7
Steven Kyriacou, Yuen Man, Karen Plumb, Matthew Shaw, Kia Rezajooi
BACKGROUND: Scoliosis patients with associated syringomyelia are at an increased risk of neurological injury during surgical deformity correction. The syrinx is therefore often addressed surgically prior to scoliosis correction to minimize this risk. It remains unclear if the presence of a persistent central canal (PCC) within the spinal cord also poses a similar risk. The aim of this study is to determine whether there is any evidence to suggest that patients with a PCC are also at a higher risk of neurological injury during surgical scoliosis correction...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28916964/presence-of-a-3fe-4s-cluster-in-a-psac-variant-as-a-functional-component-of-the-photosystem-i-electron-transfer-chain-in-synechococcus-sp-pcc-7002
#8
Adam A Pérez, Bryan H Ferlez, Amanda M Applegate, Karim Walters, Zhihui He, Gaozhong Shen, John H Golbeck, Donald A Bryant
A site-directed C14G mutation was introduced into the stromal PsaC subunit of Synechococcus sp. strain PCC 7002 in vivo in order to introduce an exchangeable coordination site into the terminal FB [4Fe-4S] cluster of Photosystem I (PSI). Using an engineered PSI-less strain (psaAB deletion), psaC was deleted and replaced with recombinant versions controlled by a strong promoter, and the psaAB deletion was complemented. Modified PSI accumulated at lower levels in this strain and supported slower photoautotrophic growth than wild type...
September 15, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28916200/islanding-detection-scheme-based-on-adaptive-identifier-signal-estimation-method
#9
M Bakhshi, R Noroozian, G B Gharehpetian
This paper proposes a novel, passive-based anti-islanding method for both inverter and synchronous machine-based distributed generation (DG) units. Unfortunately, when the active/reactive power mismatches are near to zero, majority of the passive anti-islanding methods cannot detect the islanding situation, correctly. This study introduces a new islanding detection method based on exponentially damped signal estimation method. The proposed method uses adaptive identifier method for estimating of the frequency deviation of the point of common coupling (PCC) link as a target signal that can detect the islanding condition with near-zero active power imbalance...
September 12, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28916150/use-of-cylindrical-coordinates-to-localize-prostate-cancers-on-mri-and-prostatectomy-pathology
#10
Devin N Patel, Christopher Nguyen, Deepika Sirohi, Vida Falahatian, Rola Saouf, Daniel Luthringer, Debiao Li, Hyung L Kim
PURPOSE: To describe and test a quantitative system for designating prostate tumor location on magnetic resonance imaging (MRI) and prostatectomy. A system for describing tumor location will facilitate research correlating MRI and pathology. MATERIALS AND METHODS: The prostate cylindrical coordinate (PCC) system was developed for locating prostate tumors using 3 coordinate values. The 3 coordinate values include the angular location centered on the urethra, the radial distance to the periphery and the long axis from apex to base...
September 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28915646/interleukin-15-stimulates-natural-killer-cell-mediated-killing-of-both-human-pancreatic-cancer-and-stellate-cells
#11
Jonas R M Van Audenaerde, Jorrit De Waele, Elly Marcq, Jinthe Van Loenhout, Eva Lion, Johan M J Van den Bergh, Ralf Jesenofsky, Atsushi Masamune, Geert Roeyen, Patrick Pauwels, Filip Lardon, Marc Peeters, Evelien L J Smits
Pancreatic ductal adenocarcinoma (PDAC) is the 4(th) leading cause of cancer-related death in Western countries with a 5-year survival rate below 5%. One of the hallmarks of this cancer is the strong desmoplastic reaction within the tumor microenvironment (TME), orchestrated by activated pancreatic stellate cells (PSC). This results in a functional and mechanical shield which causes resistance to conventional therapies. Aiming to overcome this resistance by tackling the stromal shield, we assessed for the first time the capacity of IL-15 stimulated natural killer (NK) cells to kill PSC and pancreatic cancer cells (PCC)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915035/photoelectrochemistry-of-photosystem-ii-in-vitro-vs-in-vivo
#12
Jenny Z Zhang, Paolo Bombelli, Katarzyna P Sokol, Andrea Fantuzzi, A William Rutherford, Christopher J Howe, Erwin Reisner
Factors governing the photoelectrochemical output of photosynthetic microorganisms are poorly understood, which can lead to energy losses through inefficient electron transfer (ET) processes. Here, we systematically compare the photoe-lectrochemistry of photosystem II (PSII) protein-films to cyano-bacteria biofilms to derive: (i) the losses in light-to-charge con-version efficiencies, (ii) gains in photocatalytic longevity, and (iii) insights into the ET mechanism at the biofilm interface. This study was enabled by the use of hierarchically structured elec-trodes, which could be tailored for high/stable loadings of PSII core complexes and Synechocystis sp...
September 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28911257/fatigue-in-multiple-sclerosis-the-contribution-of-resting-state-functional-connectivity-reorganization
#13
Alvino Bisecco, Federica Di Nardo, Renato Docimo, Giuseppina Caiazzo, Alessandro d'Ambrosio, Simona Bonavita, Rocco Capuano, Leonardo Sinisi, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi, Antonio Gallo
OBJECTIVES: To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and of sensorimotor network (SMN) network in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) and without fatigue(NF). METHODS: In all, 59 RRMS patients and 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including resting-state fMRI (RS-fMRI). Functional connectivity of the DMN and SMN was evaluated by independent component analysis (ICA)...
September 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28911053/co-ordination-of-ndh-and-cup-proteins-in-co2-uptake-in-cyanobacterium-synechocystis-sp-pcc-6803
#14
Xunling Han, Nan Sun, Min Xu, Hualing Mi
High and low affinity CO2-uptake systems containing CupA (NDH-1MS) and CupB (NDH-1MS'), respectively, have been identified in Synechocystis sp. PCC 6803, but it is yet unknown how the complexes function in CO2 uptake. In this work, we found that deletion of cupB significantly lowered the growth of cells, and deletion of both cupA and cupB seriously suppressed the growth below pH 7.0 even under 3% CO2. The rate of photosynthetic oxygen evolution was decreased slightly by deletion of cupA but significantly by deletion of cupB and more severely by deletion of both cupA and cupB, especially in response to changed pH conditions under 3% CO2...
June 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28904953/nonpaternity-and-half-siblingships-as-objective-measures-of-extramarital-sex-mathematical-modeling-and-simulations
#15
Ryosuke Omori, Nico Nagelkerke, Laith J Abu-Raddad
BACKGROUND: Understanding the epidemiology of HIV and other sexually transmitted infections (STIs) requires knowledge of sexual behavior, but self-reported behavior has limitations. We explored the reliability and validity of nonpaternity and half-siblings ratios as biomarkers of current and past extramarital sex. METHODS: An individual-based Monte Carlo simulation model was constructed to describe partnering and conception in human populations with a focus on Sub-Saharan Africa (SSA)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28902732/multimodality-radionuclide-imaging-in-a-patient-with-hereditary-paraganglioma-pheochromocytoma-syndrome
#16
So Y Yim, Valeria M Moncayo, Francisco J Pasquel, Raghuveer K Halkar
Hereditary paraganglioma (PGL)-pheochromocytoma (PCC) syndrome is a genetic disorder caused by a mutation of the tumor suppressor gene SDHD that results in a predisposition for head and neck PGLs and PCCs. We present a case of a 33-year-old woman where F-FDG PET/CT showed areas of increased uptake in both the adrenal and cervical regions, consistent with PCCs and PGLs, respectively. Further imaging revealed that PCCs were I-MIBG avid, whereas the PGLs were In-octreotide avid. This demonstrates the varying sensitivities of different imaging modalities in regard to neuroendocrine tumors and the potential for treatment using multiple targeted therapies...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28901562/involving-institutionalised-people-with-dementia-in-their-care-planning-meetings-lessons-learnt-by-the-staff
#17
Feliciano Villar, Montserrat Celdrán, Josep Vila-Miravent, Rodrigo Serrat
BACKGROUND: Applying a person-centred care (PCC) approach is an aspiration for many services attending people with dementia (PwD). However, the implementation and assessment of PCC practices represent a challenge to health professionals. AIM: To evaluate the impact on staff of a programme aiming to involve people with dementia (PwD) in their individualised care-planning (ICP) meetings in long-term residential settings; specifically, to explore the lessons that staff perceived they had learned from the experience...
September 13, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28900692/tonb-dependent-utilization-of-dihydroxamate-xenosiderophores-in-synechocystis-sp-pcc-6803
#18
Michael M Babykin, Tobias S A Obando, Vladislav V Zinchenko
In Gram-negative bacteria, transport of ferric siderophores through outer membrane is a complex process that requires specific outer membrane transporters and energy-transducing TonB-ExbB-ExbD system in the cytoplasmic membrane. The genome of the non-siderophore-producing cyanobacterium Synechocystis sp. PCC 6803 encodes all putative components of the siderophore-mediated iron uptake system. So far, there has been no experimental evidence for the existence of such a pathway in this organism. On the contrary, its reductive iron uptake pathway has been studied in detail...
September 12, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28895022/subcellular-pigment-distribution-is-altered-under-far-red-light-acclimation-in-cyanobacteria-that-contain-chlorophyll-f
#19
Erica L-W Majumder, Benjamin M Wolf, Haijun Liu, R Howard Berg, Jerilyn A Timlin, Min Chen, Robert E Blankenship
Far-Red Light (FRL) acclimation is a process that has been observed in cyanobacteria and algae that can grow solely on light above 700 nm. The acclimation to FRL results in rearrangement and synthesis of new pigments and pigment-protein complexes. In this study, cyanobacteria containing chlorophyll f, Synechococcus sp. PCC 7335 and Halomicronema hongdechloris, were imaged as live cells with confocal microscopy. H. hongdechloris was further studied with hyperspectral confocal fluorescence microscopy (HCFM) and freeze-substituted thin-section transmission electron microscopy (TEM)...
September 11, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28893432/effects-of-person-centred-care-after-an-event-of-acute-coronary-syndrome-two-year-follow-up-of-a-randomised-controlled-trial
#20
Andreas Fors, Karl Swedberg, Kerstin Ulin, Axel Wolf, Inger Ekman
AIM: To assess the long-term effect of person-centred care (PCC) in patients with acute coronary syndrome (ACS). METHOD: Patients with ACS were randomly assigned to treatment as usual (control group) or an added PCC intervention for six months. The primary endpoint was a composite score of changes in general self-efficacy≥five units, return to work or to a prior activity level and re-hospitalisation or death. RESULTS: The composite score improved in the PCC intervention group (n=94) at a two-year follow-up compared with the control group (n=105) (18...
September 6, 2017: International Journal of Cardiology
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