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JOURNAL ARTICLE
Ying Bai, Tao Han, Yunjia Dong, Chao Liang, Lu Gao, Yafeng Liu, Jiawei Zhou, Jianqiang Guo, Deyong Ge, Jing Wu, Dong Hu
BACKGROUND: Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment of lung adenocarcinoma (LUAD) and are often associated with poorer clinical outcomes. This study aimed to screen for CAF-specific genes that could serve as promising therapeutic targets for LUAD. METHODS: We established a single-cell transcriptional profile of LUAD, focusing on genetic changes in fibroblasts. Next, we identified key genes associated with fibroblasts through weighted gene co-expression network analysis (WGCNA) and univariate Cox analysis...
March 21, 2024: BMC Medical Genomics
#22
REVIEW
Aliya Botabekova, Chokan Baimukhamedov, Olena Zimba, Pankti Mehta
Rhupus, in the broad sense, refers to an overlap between rheumatoid arthritis (RA) and lupus. However, there is a paucity of data on the appropriate diagnostic/classification criteria that should be used to define rhupus. Hence, we undertook this narrative review to analyze the clinical characteristics, radiology, and treatment with a focus on diagnostic challenges and defining features of rhupus. The databases of Medline/PubMed, Scopus, and DOAJ were searched for relevant articles using the following keywords: ("Rhupus"), ("lupus" AND "erosive" AND "arthritis"), and ("lupus" AND "rheumatoid arthritis" AND "overlap")...
March 21, 2024: Rheumatology International
#23
JOURNAL ARTICLE
Preston Tse, Jiajun Yan, Yang Liu, Erin Jamula, Nancy Heddle, Renée Bazin, Nancy Robitaille, Richard Cook, Alexis Turgeon, Dean Fergusson, Marshall Glesby, Kent Cadogan Loftsgard, Melissa Cushing, Michaël Chassé, Nick Daneman, Andrés Finzi, Bruce Sachais, Philippe Bégin, Jeannie Callum, Donald M Arnold, Feng Xie
BACKGROUND: The CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1) trial was a multicenter randomized controlled trial assessing convalescent plasma in hospitalized COVID-19 patients. This study evaluates the cost-effectiveness of convalescent plasma and its impact on quality-of-life to provide insight into its potential as an alternative treatment in resource-constrained settings. METHODS: Individual patient data on health outcomes and resource utilization from the CONCOR-1 trial were used to conduct the analysis from the Canadian public payer's perspective with a time horizon of 30 days post-randomization...
March 21, 2024: Transfusion
#24
REVIEW
Yuliya Fedorchenko, Olena Zimba, Roman Yatsyshyn, Bohdana Doskaliuk, Liubomyr Zaiats, Mykhailo Fedorchenko
Patients with rheumatic diseases (RDs) are prone to a number of comorbidities, particularly those affecting the respiratory system due to inflammatory and autoimmune mechanisms. Rheumatoid arthritis (RA), systemic sclerosis (SSc), and inflammatory idiopathic myopathies (IIMs) often present with progressive interstitial lung disease (ILD). The prevalence of ILD varies among patients with RDs, with 11% in RA, 47% in SSc, and 41% in IIMs. Some diagnostic markers, including KL-6, cytokines TNF-α and IL-6, and autoantibodies (anti-CCP), play a crucial role in assessing and predicting the course of pulmonary involvement in RDs...
March 20, 2024: Rheumatology International
#25
JOURNAL ARTICLE
Pulmonary Manifestations of Systemic Lupus Erythematosus Among Adults in Aseer Region, Saudi Arabia.
Nouf A Alhammadi, Hanan Saeed Alqahtani, Syed Esam Mahmood, Abdulrahman Arif Alshahrani, Abdullaziz Motlaq A Alahmari, Abdullah Rashid Safer Alshahrani, Abdullah Saeed A Badawi, Ali Mohammed Ali Alqahtani, Abdullah Thabet A Alsalem, Mohammed Saeed M Alsultan Alqahtani, Mohammed Ali Gazzan
BACKGROUND: Nearly half of the Systemic lupus erythematosus (SLE) patients develop lung involvement. The study assessed the extent of pulmonary involvement among SLE patients and to identify the associated factors in the population. METHODOLOGY: This retrospective cohort study was conducted at Aseer Hospital and Khamis Myshat Hospital in the Southern region of Saudi Arabia. The study spanned from January 1, 2016, to June 3, 2023. Patient inclusion criteria encompassed individuals who received a definitive diagnosis and classification as per American College of Rheumatology criteria, while patients under 18 years of age and those with mixed connective tissue diseases were exclude...
2024: International Journal of General Medicine
#26
JOURNAL ARTICLE
Stylianos Tzedakis, Alexandre Challine, Sandrine Katsahian, David Malka, Romain Jaquet, Ugo Marchese, Martin Gaillard, Romain Coriat, Alix Dhote, Vincent Mallet, Heithem Jeddou, Karim Boudjema, David Fuks, Andrea Lazzati
BACKGROUND: Although the incidence of BTC is raising, national healthcare strategies to improve care lack. We aimed to explore patient clinical care pathways and strategies to improve biliary tract cancer (BTC) care. METHODS: We analysed the French National Healthcare database of all BTC inpatients between January 1, 2017 and December 31, 2021. Multinomial logistic regression adjusted odds ratios (aOR) were used to identify healthcare organisation factors that influenced access to curative care both overall and in a longitudinal sensibility analysis using optimal matching and hierarchical ascending classification to detect a subgroup of curative-care patients with a high survival over a two-year period...
March 16, 2024: European Journal of Cancer
#27
JOURNAL ARTICLE
Nazanin Nasiri, Min Hu, Mohammad Hajizadeh
PURPOSE: Breast cancer is the second leading cause of death from cancer among Canadian females. This study aimed to quantify and assess trends in education and income inequalities in the mortality rate of breast cancer in Canada from 1992 to 2019. METHODS: We constructed a census division-level dataset pooled from the Canadian Vital Death Statistics Database (CVSD), the Canadian Census of the Population (CCP), and the National Household Survey (NHS) to examine trends in education and income inequalities in the mortality rate of breast cancer in Canada over the study period...
March 19, 2024: Breast Cancer Research and Treatment
#28
JOURNAL ARTICLE
Quentin Richier, Benjamin De Valence, Dorothée Chopin, Emmanuelle Gras, Laura I Levi, Yasmine Abi Aad, Jérôme Pacanowski, Jean-Luc Meynard, Léo Plaçais, Dorothée Fey, Priscille Couture, Guillaume Martin-Blondel, Vincent Pestre, Juliette Woessner, Sophie Ancellin, Pierre Weyrich, Benjamin Carpentier, Salim Idri, Pierre Tiberghien, Laure Surgers, Thomas Hueso, Karine Lacombe
The emergence of SARS-CoV-2 Omicron variant has led to a complete reconfiguration of the therapeutic landscape, with all monoclonal antibodies having lost any neutralization activity. We report here a case series of 75 immunocompromised patients infected by the Omicron variant who benefited from COVID-19 convalescent plasma (CCP). At Day 28, the overall survival was 76% (95% CI 67-86) with no significant difference in the clinical outcome between patients with hematological malignancies, solid organ transplantation or autoimmune diseases...
March 2024: Influenza and Other Respiratory Viruses
#29
JOURNAL ARTICLE
Lara S Chapman, Heidi J Siddle, Stefan Serban, Kulveer Mankia, Christopher M Rooney, Zhain Mustufvi, Simon Pini, Karen Vinall-Collier
OBJECTIVES: Intervention in the pre-arthritis phase of RA could prevent or delay the onset of disease. The primary aim of this study was to explore perspectives of being at risk and potential preventive interventions among individuals at risk of developing RA and to identify factors influencing their engagement with prevention. A secondary aim, established during the analytical process, was to understand and compare different approaches to health-related behaviours related to prevention of RA...
2024: Rheumatology Advances in Practice
#30
JOURNAL ARTICLE
Jingkun Li, Liying Wang, Guoyong Jiang, Yuqi Wan, Jiahua Wang, Yan Li, Fuwei Pi
In this study, a novel luminescent carbon dot-rooted polysaccharide hydrogel (CDs@CCP hydrogel) was prepared by crosslinking cellulose, chitosan (CS), and polyvinyl alcohol (PVA) for simultaneous fluorescent sensing and adsorption of Cu2+ . The crosslinking of these low-cost, polysaccharide polymers greatly enhance the mechanical strength of the composite hydrogel while making the polysaccharide-based adsorbent easy to reuse. This composite hydrogel exhibited an excellent adsorption capacity (124.7 mg∙g-1 ) for residual Cu2+ in water, as well as a sensitive and selective fluorescence response towards Cu2+ with a good linear relationship (R2 > 0...
March 11, 2024: Food Chemistry
#31
JOURNAL ARTICLE
Han-Sol Park, Anna Yin, Caelan Barranta, John S Lee, Christopher A Caputo, Jaiprasath Sachithanandham, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E Fernandez, Owen R Baker, Aarthi G Shenoy, Giselle S Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L Heath, Adam C Levine, Barry R Meisenberg, Emily S Spivak, Shweta Anjan, Moises A Huaman, Janis E Blair, Judith S Currier, James H Paxton, Jonathan M Gerber, Joann R Petrini, Patrick B Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G Sutcliffe, Donald N Forthal, Martin S Zand, Edward R Cachay, Jay S Raval, Seble G Kassaye, Christi E Marshall, Anusha Yarava, Karen Lane, Nichol A McBee, Amy L Gawad, Nicky Karlen, Atika Singh, Daniel E Ford, Douglas A Jabs, Lawrence J Appel, David M Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N Baksh, Janna R Shapiro, Jiangda Ou, Yu Bin Na, Maria D Knoll, Elysse Ornelas-Gatdula, Netzahualcóyotl Arroyo-Currás, Thomas J Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J Betenbaugh, Alyssa Ziman, Daniel F Hanley, Arturo Casadevall, Shmuel Shoham, Evan M Bloch, Kelly A Gebo, Aaron Ar Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L Klein, David J Sullivan
BACKGROUND COVID-19 convalescent plasma (CCP) viral specific antibody levels that translate into recipient post-transfusion antibody levels sufficient to prevent disease progression is not defined.METHODS This secondary analysis correlated donor and recipient antibody levels to hospitalization risk among unvaccinated, seronegative CCP recipients within the outpatient, double blind, randomized clinical trial that compared CCP to control plasma. The majority of COVID-19 CCP arm hospitalizations (15/17, 88%) occurred in this unvaccinated, seronegative subgroup...
March 14, 2024: JCI Insight
#32
Jacqueline A Turner, Ali Hakimi, Hannah Lee, Jeffrey T Schowinsky, Jeffrey M Sippel, Bradford J Siegele, Raul M Torres, William A Robinson
The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis obliterans. Here, we describe the Castleman triad in a 19-year-old male with unicentric hyaline vascular type Castleman disease (HV-CD). This patient presented with an array of positive antibodies, including anti-cyclic citrullinated peptide, anti-double-stranded DNA, and Sjogren's IgG. Interestingly, the patient's rheumatologic symptoms resolved after tumor resection, while his antibody profile remained relatively unchanged...
2024: Case Reports in Immunology
#33
JOURNAL ARTICLE
Lauren Mann, Lindsey VanLooy
BACKGROUND: Individuals with Turner syndrome (TS, ORPHA 881) experience barriers in communication throughout life as they navigate both early conductive, and progressive sensorineural hearing loss amid other healthcare needs. Hearing loss is self-identified as one of the largest unmet healthcare needs. PURPOSE: The purpose of this study was to investigate the impact of treatment for hearing loss on communication confidence and quality of life measures for individuals with TS...
March 13, 2024: Orphanet Journal of Rare Diseases
#34
JOURNAL ARTICLE
Roghayeh Mostafaei, Negin Elahi, Jalal Moludi, Fardin Moradi, Leila Solouki, Seyed Mostafa Nachvak, Maryam Behrooz
BACKGROUND & AIMS: Rheumatoid arthritis is a systemic autoimmune disease that causes joint erosion, as well as damage to extra-articular organs. The aim of this study was the investigation of the association between the Mediterranean diet quality index with disease activity in patients with rheumatoid arthritis. METHODS: In this cross-sectional study 184 females with rheumatoid arthritis were studied in Kermanshah, Iran. The American College of Rheumatology's 2010 criteria were used to diagnose RA...
April 2024: Clinical Nutrition ESPEN
#35
JOURNAL ARTICLE
Miguel Hernandez, Honoria Guarino, Sarah Kozlowski, Avantika Srivastava, Rachel Schenkel, Thamara Tapia, Tyeirra B Seabrook, Denis Nash, Mary K Irvine
For people with HIV (PWH) who have psychological comorbidities, effective management of mental health issues is crucial to achieving and maintaining viral suppression. Care coordination programs (CCPs) have been shown to improve outcomes across the HIV care continuum, but little research has focused on the role of care coordination in supporting the mental health of PWH. This study reports qualitative findings from the Program Refinements to Optimize Model Impact and Scalability based on Evidence (PROMISE) study, which evaluated a revised version of an HIV CCP for Ryan White Part A clients in New York City...
March 2024: AIDS Patient Care and STDs
#36
JOURNAL ARTICLE
Eilat Shinar, Eli Jaffe, Zvika Orr, Beth G Zalcman, Joseph Offenbacher, Maxim Quint, Evan Avraham Alpert, Boaz Zadok Weiss, Baruch Berzon
Demands for whole blood (WB) and COVID-19 convalescent plasma (CCP) donations during the SARS-CoV-2 (COVID-19) pandemic presented unprecedented challenges for blood services throughout the world. This study aims to understand the motivating factors that drive WB and CCP donations in the context of the pandemic. This cross-sectional study is based on data extracted from surveys of the two volunteer donor cohorts. The findings reveal that when compared to CCP donors, WB donors were more likely to view donation as a form of social engagement (97...
March 5, 2024: Healthcare (Basel, Switzerland)
#37
JOURNAL ARTICLE
Ricardo Aguilar, Sandra López-Vergès, Anarellys Quintana, Johanna Morris, Lineth Lopez, Ana Cooke, Dimas Quiel, Natalie Buitron, Yaseikiry Pérez, Lesbia Lobo, Maura Ballesteros, Yaneth Pitti, Yamilka Diaz, Lisseth Saenz, Danilo Franco, Daniel Castillo, Elimelec Valdespino, Isabel Blanco, Emilio Romero, Alcibiades Villarreal, Idalina Cubilla-Batista
BACKGROUND: At the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, transfusion of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) emerged as a potential therapeutic strategy to help patients severely afflicted by COVID-19. The efficacy of CCP has been controversial as it depends on many variables pertaining to the plasma donor and the patient with COVID-19, for example, time of convalescence or symptoms onset. This feasibility and descriptive study aimed to assess the safety of multiple doses of CCP in mechanically ventilated, intubated patients with respiratory failure due to COVID-19...
March 2024: Health Science Reports
#38
Tejas Sinha, Jian Fu, Ashish Bains, Andrew Gangemi
The patient is a 49-year-old woman who had never used tobacco with a history of relapsing polychondritis and episcleritis. She sought treatment at our clinic for evaluation of multiple lung masses. She originally received a diagnosis by chest radiography performed to rule out sarcoidosis as the cause of episcleritis showing an abnormal findings. She had no contributory surgical, family, or social history. The autoimmune markers were notable for positive rheumatoid factor (153 IU/mL) and elevated erythrocyte sedimentation rate (97 mm/h) and C-reactive protein (65...
March 2024: Chest
#39
JOURNAL ARTICLE
Yunfeng Tang, Renliang Zhao, Min Yi, Zilu Ge, Dong Wang, Guanglin Wang, Xiangtian Deng
Chronic infected wounds often fail to heal through normal repair mechanisms, and the persistent response of reactive oxygen species (ROS) and inflammation is a major contributing factor to the difficulty in their healing. In this context, we developed an ROS-responsive injectable hydrogel. This hydrogel is composed of ε-polylysine grafted (EPL) with caffeic acid (CA) and hyaluronic acid (HA) grafted with phenylboronic acid (PBA). Before the gelation process, a mixture CaO2 @Cur-PDA (CCP) consisting of calcium peroxide (CaO2 ) coated with polydopamine (PDA) and curcumin (Cur) is embedded into the hydrogel...
March 8, 2024: Biomacromolecules
#40
JOURNAL ARTICLE
Alexandra Cîrciumaru, Yogan Kisten, Monika Hansson, Linda Mathsson-Alm, Vijay Joshua, Heidi Wähämaa, Malena Loberg Haarhaus, Joakim Lindqvist, Leonid Padyukov, Sergiu-Bogdan Catrina, Guozhong Fei, Nancy Vivar, Hamed Rezaei, Erik Af Klint, Aleksandra Antovic, Bence Réthi, Anca I Catrina, Aase Hensvold
OBJECTIVE: Individuals positive for anti-cyclic-peptide-antibodies (anti-CCP) and musculoskeletal complaints (MSK-C) are at risk for developing rheumatoid arthritis (RA). In this study we aimed to investigate factors involved in arthritis progression. METHODS: Anti-CCP2-positive individuals with MSK-C referred to a rheumatologist were recruited. Individuals lacked arthritis at clinical and ultrasound examination and were followed for ≥three years or until clinical arthritis diagnosis...
March 8, 2024: Rheumatology
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