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https://www.readbyqxmd.com/read/28222760/tlr4-rs41426344-increases-susceptibility-of-rheumatoid-arthritis-ra-and-juvenile-idiopathic-arthritis-jia-in-a-central-south-chinese-han-population
#1
Yan Wang, Lianghui Chen, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li, Liang Tang
BACKGROUND: The aim of the study was to determine whether polymorphisms in toll-like receptor 4 (TLR4) confer susceptibility to rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population. METHODS: Genotyping for six well studied polymorphisms (rs4986790, rs4986791, rs10759932, rs41426344, rs11536889 and rs7873784) in TLR4 gene were conducted in 1074 unrelated patients with RA and 1692 healthy control subjects, as well as in 217 unrelated patients with JIA and 378 healthy control subjects using direct sequencing technique...
February 21, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28210620/association-of-ptpn22-haplotypes-1123g-c-1858c-t-with-rheumatoid-arthritis-in-western-mexican-population
#2
Yeniley Ruiz-Noa, Jorge Ramón Padilla-Gutiérrez, Jorge Hernández-Bello, Claudia Azucena Palafox-Sánchez, Yeminia Valle, Edith Oregón-Romero, Ana Laura Pereira-Suárez, Ana Guilaisne Bernard-Medina, José Francisco Muñoz-Valle
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance. Two polymorphic variants (-1123G>C and +1858C>T) at PTPN22 gene that encodes this protein have been associated with autoimmune disorders and found in strong linkage disequilibrium in Caucasian population...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28207326/micro-rna-146a-but-not-irak1-is-associated-with-rheumatoid-arthritis-in-the-tunisian-population
#3
Hana Ben Hassine, Asma Boumiza, Rim Sghiri, Khadija Baccouche, Imen Boussaid, Ahlem Atig, Zahid Shakoor, Elyes Bouajina, Ramzi Zemni
BACKGROUND: Rheumatoid arthritis (RA) is characterized by the production of an array of proinflammatory cytokines through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Interleukin-1 receptor (IL-1R) and Toll-like receptors contain a common cytoplasmic motif the Toll/IL-1R (TIR) homology domain. This motif is required for NF-κB activation. IL-1R-associated kinase 1 (IRAK1) is a key adapter molecule recruited during the signaling cascade of the TIR...
February 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28194259/anti-inflammatory-activity-of-a-sulfated-polysaccharide-isolated-from-an-enzymatic-digest-of-brown-seaweed-sargassum-horneri-in-raw-264-7-cells
#4
Kalu Kapuge Asanka Sanjeewa, Ilekkuttige Priyan Shanura Fernando, Eun-A Kim, Ginnae Ahn, Youngheun Jee, You-Jin Jeon
BACKGROUND/OBJECTIVES: Sargassum horneri is an edible brown alga that grows in the subtidal zone as an annual species along the coasts of South Korea, China, and Japan. Recently, an extreme amount of S. horneri moved into the coasts of Jeju Island from the east coast of China, which made huge economic and environmental loss to the Jeju Island. Thus, utilization of this biomass becomes a big issue with the local authorities. Therefore, the present study was performed to evaluate the anti-inflammatory potential of crude polysaccharides (CPs) extracted from S...
February 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28184355/spiroplasma-eriocheiris-adhesin-like-protein-alp-interacts-with-epidermal-growth-factor-egf-domain-proteins-to-facilitate-infection
#5
Libo Hou, Yuhan Liu, Qi Gao, Xuechuan Xu, Mingxiao Ning, Jingxiu Bi, Hui Liu, Min Liu, Wei Gu, Wen Wang, Qingguo Meng
Spiroplasma eriocheiris is a novel pathogen found in recent years, causing the tremor disease (TD) of Chinese mitten crab Eriocheir sinensis. Like Spiroplasma mirum, S. eriocheiris infects the newborn mouse (adult mice are not infected) and can cause cataract. Adhesion-related protein is an important protein involved in the interaction between pathogen and host. In this study, the Adhesin-like Protein (ALP) of S. eriocheiris was detected on its outer membrane by using immune electron microscopy, and was found to be involved in the bacterium's infection of mouse embryo fibroblasts (3T6-Swiss albino)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28182854/anti-citrullinated-protein-antibodies-are-associated-with-neutrophil-extracellular-traps-in-the-sputum-in-relatives-of-rheumatoid-arthritis-patients
#6
M Kristen Demoruelle, Kylie K Harrall, Linh Ho, Monica M Purmalek, Nickie L Seto, Heather M Rothfuss, Michael H Weisman, Joshua J Solomon, Aryeh Fischer, Yuko Okamoto, Lindsay B Kelmenson, Mark C Parish, Marie Feser, Chelsie Fleischer, Courtney Anderson, Michael Mahler, Jill M Norris, Mariana J Kaplan, Brian D Cherrington, V Michael Holers, Kevin D Deane
OBJECTIVES: Studies suggest that rheumatoid arthritis (RA)-related autoimmunity is initiated at a mucosal site. However, the factors associated with the mucosal generation of this autoimmunity are unknown, especially in individuals who are at-risk for future RA. Therefore, we tested anti-cyclic citrullinated peptide (anti-CCP) antibodies in the sputum of RA-free first-degree relatives (FDRs) of RA patients and patients with classifiable RA. METHODS: We evaluated induced sputum and serum from 67 FDRs and 20 RA subjects for anti-CCP-IgA and anti-CCP-IgG, with cut-off levels for positivity determined in a control population...
February 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28182837/fibromyalgia-predicts-two-year-changes-in-functional-status-in-rheumatoid-arthritis-patients
#7
Hyein Kim, Jing Cui, Michelle Frits, Christine Iannaccone, Jonathan Coblyn, Nancy A Shadick, Michael E Weinblatt, Yvonne C Lee
BACKGROUND/PURPOSE: Previous cross sectional studies have shown that rheumatoid arthritis (RA) patients with fibromyalgia (FM) have higher disease activity, greater medical costs and worse quality of life compared to RA patients without FM. We determined the impact of FM on 2-year changes in functional status of RA patients in a prospective study. METHODS: Subjects included participants in the Brigham Rheumatoid Arthritis Sequential Study enrolled in a substudy of the effects of pain in RA...
February 9, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28181986/local-administration-of-thiamine-ameliorates-ongoing-pain-in-a-rat-model-of-second-degree-burn
#8
Kangkang Zhang, Yali Pei, Zhihao Gan, Xuetao Zhang, Ye Duan, Yuepeng Liu, Wei Liu
The objective of this study was to develop rat model of second-degree burn pain and test analgesic efficacy of local thiamine administration. Automatic temperature-controlled hot plate was set at 85 ± 0.1°C with a filter paper on the top. Rats were thrust on hot plate landing on plantar surface for 4 to 7 and 10 seconds, respectively. Burnt skin was observed. Hematoxylin and eosin staining and Masson staining were used to monitor burn degree. Gait analysis detected change of locomotion. Allodynia and hyperalgesia in the burnt area were evaluated with von Frey test and Hargreaves Test, and ongoing pain was detected with conditional place preference test...
February 7, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28179568/kinetics-subcellular-localization-and-contribution-to-parasite-virulence-of-a-trypanosoma-cruzi-hybrid-type-a-heme-peroxidase-tcapx-ccp
#9
Martín Hugo, Alejandra Martínez, Madia Trujillo, Damián Estrada, Mauricio Mastrogiovanni, Edlaine Linares, Ohara Augusto, Federico Issoglio, Ari Zeida, Darío A Estrín, Harry F G Heijnen, Lucía Piacenza, Rafael Radi
The Trypanosoma cruzi ascorbate peroxidase is, by sequence analysis, a hybrid type A member of class I heme peroxidases [TcAPx-cytochrome c peroxidase (CcP)], suggesting both ascorbate (Asc) and cytochrome c (Cc) peroxidase activity. Here, we show that the enzyme reacts fast with H2O2 (k = 2.9 × 10(7) M(-1)⋅s(-1)) and catalytically decomposes H2O2 using Cc as the reducing substrate with higher efficiency than Asc (kcat/Km = 2.1 × 10(5) versus 3.5 × 10(4) M(-1)⋅s(-1), respectively). Visible-absorption spectra of purified recombinant TcAPx-CcP after H2O2 reaction denote the formation of a compound I-like product, characteristic of the generation of a tryptophanyl radical-cation (Trp(233•+))...
February 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28176336/effect-of-hypothermic-machine-perfusion-on-the-preservation-of-kidneys-donated-after-cardiac-death-a-single-center-randomized-controlled-trial
#10
Wei Wang, Dawei Xie, Xiaopeng Hu, Hang Yin, Hang Liu, Xiaodong Zhang
To assess the application of a hypothermic machine perfusion device (LifePort) in kidney transplantation from donation after cardiac death (DCD) donors, 24 pairs of DCD kidneys were randomly divided into two groups: one of the paired kidneys from the same donor was perfused with the LifePort machine (hypothermic machine perfusion [HMP]), and the contralateral kidney was prepared using common static cold preservation (CCP). The two groups were compared with respect to the incidence of delayed graft function (DGF), level of graft function, and pathological changes in time-zero biopsy specimens...
February 8, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28164544/clinical-significance-of-red-blood-cell-distribution-width-and-inflammatory-factors-for-the-disease-activity-in-rheumatoid-arthritis
#11
Li Yunchun, Wang Yue, Fang Z Jun, Su Qizhu, Ding Liumei
BACKGROUND: To evaluate the significance of red blood cell distribution width (RDW) and other factors for the disease activity in rheumatoid arthritis (RA). METHODS: Each patient underwent clinical examination and blood sampling for assessment of serum high-sensitivity C-reactive protein (hs-CRP) levels, erythrocyte sedimentation rate (ESR), hemoglobin concentration (Hb), hematocrit (HCT), RDW, and other erythrocyte parameters (mean corpuscular volume [MCV], mean cell Hb [MCH], mean corpuscular Hb concentration [MCHC])...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28163267/cornu-cervi-pantotrichum-supplementation-improves-physiological-adaptions-during-intensive-endurance-training
#12
Wen-Ching Huang, Chi-Chang Huang, Hsiao-Li Chuang, Wen-Chyuan Chen, Mei-Chich Hsu
Cornu cervi pantotrichum (CCP), used in traditional Chinese medicine, is a well-known yang-invigorating agent with multifunctional bioactivities. We previously showed, through an acute exercise challenge, that short-term CCP supplementation improved physical activities and fatigue-associated biochemical indices. Questions about the long-term effects of CCP treatment on exercise performance and physical fatigue, as well as safety, with intensive exercise training need further research. ICR-strain mice were randomly assigned to three groups: (1) sedentary control and vehicle treatment (SC); (2) exercise training with vehicle treatment (ET); (3) ET with CCP treatment at 4108 mg/kg/day (ET+CCP)...
February 3, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28154345/elevated-serum-levels-of-interleukin-29-are-associated-with-disease-activity-in-rheumatoid-arthritis-patients-with-anti-cyclic-citrullinated-peptide-antibodies
#13
Qiong-Jie Chang, Cheng Lv, Feng Zhao, Ting-Shuang Xu, Ping Li
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that may lead to progressive joint destruction. The anti-cyclic citrullinated peptide (anti-CCP) antibody is an essential marker for the diagnosis of RA and has a crucial role in the bone destruction in RA. Recent studies have shown that interleukin (IL)-29, a vital member of type III interferon (IFN) family, could enhance proinflammatory cytokine production and might be involved in the joint destruction in RA. Therefore, in this study, we aimed to examine the role of IL-29 in RA patients with anti-CCP antibodies...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28151455/association-of-human-leukocyte-antigen-drb1-with-anti-cyclic-citrullinated-peptide-autoantibodies-in-saudi-patients-with-rheumatoid-arthritis
#14
Abdullah Alrogy, Abduallah Dirar, Waleed Alrogy, Hana Fakhoury, Ali Hajeer
BACKGROUND: The genetic association between human leukocyte antigen (HLA)-DRB1 alleles and the risk of development of autoantibodies has been investigated, but there are few studies from the Gulf region. OBJECTIVES: To investigate the association between the HLA-DRB1 shared epitope and the risk for development of autoantibodies in rheumatoid arthritis (RA) patients in a Saudi population. DESIGN: Analytical cross-sectional study. SETTING: Tertiary care hospital in Riyadh, Saudi Arabia...
January 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28146179/toward-advanced-nursing-practice-along-with-people-centered-care-partnership-model-for-sustainable-universal-health-coverage-and-universal-access-to-health
#15
Tomoko Kamei, Keiko Takahashi, Junko Omori, Naoko Arimori, Michiko Hishinuma, Kiyomi Asahara, Yoko Shimpuku, Kumiko Ohashi, Junko Tashiro
Objective: this study developed a people-centered care (PCC) partnership model for the aging society to address the challenges of social changes affecting people's health and the new role of advanced practice nurses to sustain universal health coverage. Method: a people-centered care partnership model was developed on the basis of qualitative meta-synthesis of the literature and assessment of 14 related projects. The ongoing projects resulted in individual and social transformation by improving community health literacy and behaviors using people-centered care and enhancing partnership between healthcare providers and community members through advanced practice nurses...
January 30, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28139323/photosynthesis-and-aboveground-carbon-allocation-of-two-co-occurring-poplar-species-in-an-urban-brownfield
#16
Diane Radwanski, Frank Gallagher, Dirk W Vanderklein, Karina V R Schäfer
Phytoremediation, a technique used to reclaim heavy metal-contaminated soils, requires an understanding of plant physiological responses to heavy metals. However, the majority of studies documenting heavy metal impact on plant functioning have been performed in laboratory or greenhouse settings. We predicted that increased soil heavy metal concentrations reduce photosynthesis and biomass production in trees growing in metal contaminated soil in a naturally re-vegetated urban brownfield. Leaf gas exchange, leaf carbon and nitrogen concentration, and tree biomass were recorded and compared for Populus deltoides and Populus tremuloides growing in an urban brownfield...
January 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28137398/anti-ccp-antibodies-are-not-a-marker-of-severity-in-established-rheumatoid-arthritis-a-magnetic-resonance-imaging-study
#17
Lílian Santuza Santos Porto, Wilson Campos Tavares, Dário Alves da Silva Costa, Cristina Costa Duarte Lanna, Adriana Maria Kakehasi
INTRODUCTION: The presence of anti-CCP is an important prognostic tool of rheumatoid arthritis (RA). But research is still ongoing on its relationship with disease activity and functional capacity. OBJECTIVES: To study the relationship between anti-CCP and disease activity, functional capacity and structural damage indexes, by means of conventional radiography (CR) and magnetic resonance imaging (MRI), in cases of established RA. METHODS: Cross-sectional study with RA patients with 1-10 disease duration...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28132614/insight-into-the-intermolecular-recognition-mechanism-involved-in-complement-component-4-activation-through-serine-protease-trypsin
#18
Vikrant Kumar Sinha, Om Prakash Sharma, Muthuvel Suresh Kumar
Serine protease cleaved Complement component 4 (C4) at sessile loop, which is significant for completion of lectin and classical complement pathways at the time of infections. The co-crystalized structure of C4 with Mannose-binding protein-associated serine protease 2 (MASP2) provided the structural and functional aspects of its interaction and underlined the C4 activation by MASP2. The same study also revealed the significance of Complement control protein (CCP) domain through mutational study, where mutated CCP domain led to the inhibition of C4 activation...
January 29, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28130179/clear-cell-papillary-renal-cell-carcinoma-new-clinical-and-imaging-characteristics
#19
Kai Wang, Jessica Zarzour, Soroush Rais-Bahrami, Jennifer Gordetsky
OBJECTIVE: To investigate clear cell papillary (CCP) renal cell carcinoma (RCC), an uncommon tumor of low malignant potential characterized by low-grade, clear cells, showing papillary and tubular architecture. This relatively newly described entity is still being characterized. We present our series of CCP RCC with new clinical and imaging findings. METHODS: We reviewed the clinical, pathologic, and imaging findings of 28 CCP RCCs in 21 patients identified from our institution between 2010 and 2016...
January 24, 2017: Urology
https://www.readbyqxmd.com/read/28128286/role-of-cytosolic-carboxypeptidase-5-in-neuronal-survival-and-spermatogenesis
#20
Hui-Yuan Wu, Peng Wei, James I Morgan
Proteins may undergo a type of posttranslational modification - polyglutamylation, where a glutamate residue is enzymatically linked to the γ-carboxyl group of a glutamate in the primary sequence of proteins and additional glutamates are then sequentially added via α-carboxyl-linkages to the growing glutamate side chain. Nna1 (a.k.a. CCP1) defines the 6-member cytosolic carboxypeptidase (CCP) family that metabolizes polyglutamate side chain and its loss results in neurodegeneration and male infertility. Whereas most CCPs catalyze hydrolysis of α-carboxyl-linked glutamates, CCP5 uniquely metabolizes the γ-carboxyl linked, branch point glutamate...
January 27, 2017: Scientific Reports
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