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https://www.readbyqxmd.com/read/29788080/using-registry-data-to-construct-a-comparison-group-for-programmatic-effectiveness-evaluation-the-new-york-city-hiv-care-coordination-program
#1
McKaylee M Robertson, Levi Waldron, Rebekkah S Robbins, Stephanie Chamberlin, Kate Penrose, Bruce Levin, Sarah Kulkarni, Sarah L Braunstein, Mary K Irvine, Denis Nash
Many non-randomized interventions rely upon a pre-post design to evaluate effectiveness. Such designs cannot account for events external to the intervention that may produce the outcome. We describe a method to construct a surveillance registry-based comparison group, which allows for estimating the effectiveness of the intervention while controlling for secular trends in the outcome of interest. Using data from the New York City population-based human immunodeficiency virus Surveillance Registry, we created a contemporaneous comparison group for persons enrolled in the New York City human immunodeficiency virus Care Coordination Program (CCP) from December 2009 to March 2013...
May 21, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29766713/probing-dna-hybridization-equilibrium-by-cationic-conjugated-polymer-for-highly-selective-detection-and-imaging-of-single-nucleotide-mutation
#2
Zehao Li, Xu Zhou, Lidan Li, Shue Liu, Congshan Wang, Lina Li, Changyuan Yu, Xin Su
Hybridization-based probes emerge as a promising tool for nucleic acid target detection and imaging. However, the single-nucleotide selectivity is still challenging because the specificity of hybridization reaction is typically low at room temperature. We disclose an effective and simple method for highly selective detection and in situ imaging of single-nucleotide mutation (SNM) by taking the advantages of the specific hybridization of short duplex and the signal amplifying effect of cationic conjugated polymer (CCP)...
May 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29760223/genomic-heterogeneity-and-the-small-renal-mass
#3
Daiki Ueno, Zuoquan Xie, Marta Boeke, Jamil Syed, Kevin A Nguyen, Patrick McGillivray, Adebowale Adeniran, Peter A Humphrey, Garrett M Dancik, Yuval Kluger, Zongzhi Liu, Harriet M Kluger, Brian Shuch
PURPOSE: Tumor heterogeneity may represent a barrier to pre-operative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors. EXPERIMENTAL DESIGN: We conducted a study from 2013 through 2016, that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy...
May 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29735168/image-analysis-of-fibrosis-in-labial-salivary-glands-of-patients-with-systemic-autoimmune-diseases-close-correlation-of-lobular-fibrosis-to-seropositive-rheumatoid-arthritis-and-increased-anti-ccp-and-rf-titres-in-the-serum
#4
Krisztián Katona, Nelli Farkas, Mária Kneif, Gábor SütŐ, Tímea Berki, Balázs Balatonyi, Tamás Tornóczky
Lobular fibrosis in labial salivary glands of patients with systemic autoimmune disease is a rarely examined and rather neglected histological change. Its significance and disease association is poorly understood. Our aim was to explore the clinical correlations of fibrosis in labial salivary gland samples using objective methods and laboratory parameters. Labial salivary gland samples from more than 300 patients over a 3-year period were selected from the archives of the pathology department, histologically examined, digitised, image analysed and statistically evaluated to identify the presence and intensity of lobular fibrosis, its relation to age, clinical diagnoses of systemic autoimmune disease and the presence of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP), antinuclear antibodies (ANAs), and anti-dsDNA serum markers...
May 4, 2018: Pathology
https://www.readbyqxmd.com/read/29731460/-diagnosis-and-treatment-of-rheumatoid-arthritis-toward-the-best-practice-management-of-elderly-rheumatoid-arthritis
#5
Takahiko Sugihara
Elderly rheumatoid arthritis(RA)is classified into 2 clinical subsets, elderly-onset RA(EORA)and younger-onset elderly RA. Anti-CCP antibody positive, high disease activity, presence of bone erosion are associated with progression of joint destruction of EORA, and intensive treatment using a treat-to-target strategy is needed in the patients with the poor prognostic factors. Working ability is one of most important goals for RA and also non-frail status should be goal of elderly RA, since it is associated with health expectancy...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29723026/crisis-counselor-perceptions-of-job-training-stress-and-satisfaction-during-disaster-recovery
#6
Nikki D Bellamy, Min Qi Wang, Lori A McGee, Julie S Liu, Maryann E Robinson
OBJECTIVE: The United States Crisis Counseling Assistance and Training Program (CCP; authorized by the Robert T. Stafford Disaster Relief and Emergency Assistance Act, 1974/2013) aims to provide disaster-recovery support to communities following natural or human-caused disasters through outreach. Job satisfaction among the crisis counselors the CCP employs may affect the delivery of outreach services to survivors and their communities. The present study was conducted to gain insight into CCP crisis counselors' experiences with job training and work-related stress as predictors of job satisfaction...
May 3, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29720260/smoking-body-mass-index-disease-activity-and-the-risk-of-rapid-radiographic-progression-in-patients-with-early-rheumatoid-arthritis
#7
Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T H Jacobsson, Carl Turesson
BACKGROUND: Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characteristics and subsequent rapid radiographic progression (RRP). METHODS: An inception cohort of patients with early RA (symptom duration < 12 months), recruited during 1995-2005 from a defined area (Malmö, Sweden), was investigated...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29715363/hip-joint-contact-pressure-distribution-during-pavlik-harness-treatment-of-an-infant-hip-a-patient-specific-finite-element-model
#8
Behzad Vafaeian, Samer Adeeb, Marwan El-Rich, Dornoosh Zonoobi, Abhilash R Hareendranathan, Jacob L Jaremko
Developmental dysplasia of the hip (DDH) in infants under 6 months of age is typically treated by the Pavlik harness (PH). During successful PH treatment, a subluxed/dislocated hip is spontaneously reduced into the acetabulum, and DDH undergoes self-correction. PH treatment may fail due to avascular necrosis (AVN) of the femoral head. An improved understanding of mechanical factors accounting for the success/failure of PH treatment may arise from investigating articular cartilage contact pressure (CCP) within a hip during treatment...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29713794/comparison-of-the-diagnostic-potential-of-three-anti-citrullinated-protein-antibodies-as-adjuncts-to-rheumatoid-factor-and-ccp-in-a-cohort-of-south-african-rheumatoid-arthritis-patients
#9
Pieter W A Meyer, Mahmood T M Ally, Bridget Hodkinson, Ronald Anderson, Mohammed Tikly
PURPOSE: A retrospective comparison of the prevalence and diagnostic value of anti-Sa, anti-CEP-1, and anti-MCV autoantibodies relative to those of the established autoantibodies, composite RF and anti-CCP-IgG used routinely for RA diagnosis as a component of the ACR 2010 criteria, in a cohort of disease-modifying anti-rheumatic drug naïve African RA patients (n = 75). METHODS: Serum concentrations of anti-Sa, anti-CEP-1 and anti-MCV autoantibodies were measured using ELISA procedures, while anti-CCP-IgG antibodies were determined by fluorescence enzyme immunoassay, and composite RF by latex-enhanced laser nephelometry...
April 30, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29701391/diagnostic-challenges-in-chronic-constrictive-pericarditis
#10
Ana Braga, Afonso Oliveira, Kevin Domingues, Maria João Andrade, Miguel Abecacis, José Pedro Neves
INTRODUCTION: Chronic constrictive pericarditis (CCP) is a disease that has multiple possible causes and is associated with variable clinical findings, depending on its severity. It develops insidiously, and in many cases, particularly in developed countries, no antecedent diagnosis can be found. These cases are termed idiopathic. Tuberculosis is the leading cause of constrictive pericarditis in developing nations but represents only a small minority in developed countries. METHODS: Here the authors describe two different case reports where tuberculosis was the probable cause of CCP...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701040/-clinical-therapeutic-effects-on-rheumatoid-arthritis-treated-with-the-assisted-therapy-of-acupuncture-at-the-points-detected-with-thermosensitive-moxibustion-in-zhuang-medicine
#11
An Huang, Yuzhou Pang, Qianqian Tang, Jing Xu, Jiyong Lin, Jianying Li
OBJECTIVE: To evaluate the clinical therapeutic effects and safety on rheumatoid arthritis (RA) treated with acupuncture at the points detected with thermosensitive moxibustion in Zhuang medicine combined with western medication. METHODS: A total of 168 RA patients in compliance with the inclusive criteria were collected and randomized into an observation group and a control group, 84 cases in each one. In the control group, in reference to the updated guideline of new drugs by the European League Against Rheumatism (EULAR) in 2013, the medication scheme was formulated for oral administration, methotrexate tablet 7...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29692006/-simulation-on-photosynthetic-co-2-response-of-quercus-variabilis-and-robinia-pseudoacacia-in-the-southern-foot-of-the-taihang-mountain-china
#12
Bo Ren, Jun Li, Xiao Juan Tong, Yan Mei Mu, Ping Meng, Jin Song Zhang
In this study, leaf photosynthetic CO2 -response curves of Quercus variabilis and Robinia pseudoacacia were measured using a Li-6400XT photosynthetic measurement system in the southern foot of the Taihang Mountain, China. The rectangular hyperbola model (RH), nonrectangular hyperbola model (NRH) andYe model (YZP) were used to fit photosynthetic-CO2 response curves and compare photosynthetic parameters, including the maximum net photosynthetic rate (Amax ), the initial carboxylation rate (η), light respiration rate (Rp ), CO2 compensation point (CCP) and CO2 saturation point (CSP)...
January 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29684420/novel-cancer-gene-variants-and-gene-fusions-of-triple-negative-breast-cancers-tnbcs-reveal-their-molecular-diversity-conserved-in-the-patient-derived-xenograft-pdx-model
#13
Jaeyun Jung, Kiwon Jang, Jung Min Ju, Eunji Lee, Jong Won Lee, Hee Jung Kim, Jisun Kim, Sae Byul Lee, Beom Seok Ko, Byung Ho Son, Hee Jin Lee, Gyungyup Gong, Sei Yeon Ahn, Jung Kyoon Choi, Shree Ram Singh, Suhwan Chang
Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 patient-derived xenografts (PDXs) of TNBC. The overall success rate of PDX implantation was 45%, much higher than estrogen receptor (ER)-positive cases. Immunohistochemical analysis revealed conserved ER/PR/Her2 negativity (with two exceptions) between the original and PDX tumors...
April 20, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29683356/is-current-smoking-status-and-its-relationship-to-anti-cyclic-citrullinated-peptide-antibodies-a-predictor-of-worse-response-to-biological-therapies-in-rheumatoid-arthritis-patients
#14
V Torrente-Segarra, S A Bergstra, K Salomon-Escoto, Jap Da Silva, D J Veale, S Al-Emadi, Twj Huizinga
OBJECTIVE: To assess the association between smoking, anti-cyclic citrullinated peptide (anti-CCP) antibody status, and clinical efficacy of biological therapies in rheumatoid arthritis (RA) patients. METHOD: This retrospective clinical practice setting study included 1349 RA patients from the METEOR database (aged >18 years). We collected data on sociodemographics, smoking status (smoker, <10, 10-19, and >20 cigarettes/day; ex-smoker; non-smoker), baseline disease activity parameters and anti-CCP, previous disease-modifying anti-rheumatic drugs (DMARDs), biological therapy, combined therapy (steroids and DMARDs), and follow-up disease activity...
April 23, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29681211/a-survey-on-client-centered-practice-among-danish-occupational-therapists
#15
Anette Enemark Larsen, Helene Nyborg Adamsen, Sarah Boots, Emma Caecilie Guttzeit Delkus, Louise Lunde Pedersen, Jeanette Reffstrup Christensen
BACKGROUND: In Denmark, the cost of healthcare services comprise 12% of the gross domestic product. A recommended method for optimizing effectiveness of and enhance client satisfaction with healthcare is client-centred practice (CCP), a central component of occupational therapy ideology. However, Danish occupational therapists' perceptions of CCP, including the facilitators and barriers that may contribute to CCP, have never been examined. AIM: To examine Danish occupational therapists' perceptions of CCP...
April 23, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29679140/comparison-of-cell-cycle-progression-score-with-two-immunohistochemical-markers-pten-and-ki-67-for-predicting-outcome-in-prostate-cancer-after-radical-prostatectomy
#16
Priscilla Léon, Geraldine Cancel-Tassin, Sara Drouin, Marie Audouin, Justine Varinot, Eva Comperat, Xavier Cathelineau, François Rozet, Christophe Vaessens, Steven Stone, Julia Reid, Zaina Sangale, Patrick Korman, Morgan Rouprêt, Gaelle Fromond-Hankard, Olivier Cussenot
PURPOSE: Previous studies of the cell cycle progression (CCP) score in surgical specimens of prostate cancer (PCa) in patients treated by radical prostatectomy (RP) demonstrated significant association with time to biochemical recurrence (BCR). In this study, we compared the ability of the CCP score and the expression of PTEN or Ki-67 to predict BCR in a cohort of patients treated by RP. Finally, we constructed the best predictive model for BCR, incorporating biomarkers and relevant clinical variables...
April 20, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29677783/investigation-of-surface-properties-of-fluorocarbon-films-produced-using-plasma-techniques
#17
Se-Bi Jung, Youn-Jeong Cho, Jihye Lee, Kang-Bong Lee, Yeonhee Lee
Different fluorocarbon thin films were deposited on Si substrates using two different plasma polymerization methods. Fluorine-containing hydrophobic thin films were obtained using inductively coupled plasma (ICP) and capacitively coupled plasma (CCP) with a mixture of fluorocarbon precursors (C2F6, C3F8, or c-C4F8) and an unsaturated hydrocarbon (C2H2). Different process parameters for plasma polymerization (e.g., processing time) were used to generate various fluorocarbon thin films. The hydrophobic properties and mechanical properties of the new products were measured using a profilometer, water contact angle measurements, pencil hardness, and a 90° peel test...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29676121/-research-on-chemical-compositions-in-different-processed-products-of-cervi-cornu-pantotrichum
#18
Yan-Hua Wang, Yin-Shi Sun, Lei Zhang, Chang Liu, Rui-Ze Gong
To investigate the chemical compositions of "antler powder" and "antler slice", two types of processed products of Cervi Cornu Pantotrichum (CCP) documented in Chinese Pharmacopoeia. With polysaccharides, crude protein, amino acids, fatty acids, mineral elements, biogenic amines, nucleosides and nucleobases as the evaluating indicators, the antler powder and antler slice processed with methods documented in Chinese Pharmacopoeia were compared in this study. The results showed that as compared with the antler powder by directly "chopping into pieces, and grinding into fine powder", the crude protein, amino acids, biogenic amines, nucleosides and nucleobases contents were reduced by 5...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29670135/clinical-characteristics-and-risk-factors-for-overlapping-rheumatoid-arthritis-and-sj%C3%A3-gren-s-syndrome
#19
Huaxia Yang, Sainan Bian, Hua Chen, Li Wang, Lidan Zhao, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
This study investigated the clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome (RA/SS). Patients with RA/SS in Peking Union Medical College Hospital from January 2012 to January 2017 were retrospectively analysed and compared to those of sex- and age-matched RA or SS controls. Logistic regression analysis was used to identify risk factors. Altogether, 105 consecutive patients with RA/SS were enrolled. Ninety-seven (92.4%) of them were female, with a mean age of 51...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29668686/a-noncanonical-role-for-dynamin-1-in-regulating-early-stages-of-clathrin-mediated-endocytosis-in-non-neuronal-cells
#20
Saipraveen Srinivasan, Christoph J Burckhardt, Madhura Bhave, Zhiming Chen, Ping-Hung Chen, Xinxin Wang, Gaudenz Danuser, Sandra L Schmid
Dynamin Guanosine Triphosphate hydrolases (GTPases) are best studied for their role in the terminal membrane fission process of clathrin-mediated endocytosis (CME), but they have also been proposed to regulate earlier stages of CME. Although highly enriched in neurons, dynamin-1 (Dyn1) is, in fact, widely expressed along with Dyn2 but inactivated in non-neuronal cells via phosphorylation by glycogen synthase kinase-3 beta (GSK3β) kinase. Here, we study the differential, isoform-specific functions of Dyn1 and Dyn2 as regulators of CME...
April 18, 2018: PLoS Biology
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