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https://www.readbyqxmd.com/read/28713112/effect-of-casein-phosphopeptide-amorphous-calcium-phosphate-and-three-calcium-phosphate-on-enamel-microhardness
#1
En Hr Haghgou, Roza Haghgoo, Mohamad R Roholahi, Zahra Ghorbani
AIM: This study aims to investigate the effect of casein phos-phopeptide-amorphous calcium phosphate and three calcium phosphate (CPP-ACP and TCP) on increasing the microhardness of human enamel after induction of erosion. MATERIALS AND METHODS: A total of 26 healthy human-impacted third molar teeth were chosen, and their hardness measured using a microhardness testing machine. The samples were immersed in Coca Cola (pH = 4.7) for 8 minutes. Then, micro-hardness was measured again, and these samples were randomly divided into four groups (two control groups and two experimental groups)...
July 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28708862/anti-citrullinated-protein-antibody-positive-rheumatoid-arthritis-is-primarily-determined-by-rheumatoid-factor-titre-and-the-shared-epitope-rather-than-smoking-per-se
#2
Dan Murphy, Derek Mattey, David Hutchinson
OBJECTIVE: To analyse the relationship between rheumatoid factor (RF) titre, smoking and HLA-DRB1 alleles coding a "shared epitope" (SE) in relation to anti-citrullinated protein antibody (ACPA) positivity in rheumatoid arthritis (RA). METHODS: RA patients (n = 658) attending rheumatology clinics in Cornwall, UK (cohort 1) were stratified according to RF and ACPA titre, and smoking pack years at diagnosis. A further 409 RA patients from North Staffordshire, UK (cohort 2) were studied to confirm the relationship between RF levels, smoking and ACPA positivity in relation to SE status...
2017: PloS One
https://www.readbyqxmd.com/read/28702426/the-chemical-characteristics-and-immune-modulating-activity-of-polysaccharides-isolated-from-cold-brew-coffee
#3
Kwang-Soon Shin
To elucidate new biological ingredients in cold-brew coffee extracted with cold water, crude polysaccharide (CCP-0) was isolated by ethanol precipitation, and its immune-stimulating activities were assayed. CCP-0 mainly comprised galactose (53.6%), mannose (15.7%), arabinose (11.9%), and uronic acid (12.4%), suggesting that it might exist as a mixture of galactomannan and arabinogalactan. CCP-0 significantly increased cell proliferation on both murine peritoneal macrophages and splenocytes in a dose dependent manner...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28698517/the-plasticity-of-th17-cells-in-the-pathogenesis-of-rheumatoid-arthritis
#4
REVIEW
Shigeru Kotake, Toru Yago, Tsuyoshi Kobashigawa, Yuki Nanke
Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells (i.e., "nonclassic Th1 cells"), which are reported to be more pathogenic than Th17 cells per se. Thus, the association of Th cells in the pathogenesis of autoimmune disease has become more complicated. We recently reported using peripheral blood from untreated and early-onset RA patients that the ratio of CD161+Th1 cells (i.e...
July 10, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28696311/escherichia-coli-cytochrome-c-peroxidase-is-a-respiratory-oxidase-that-enables-the-use-of-hydrogen-peroxide-as-a-terminal-electron-acceptor
#5
Maryam Khademian, James A Imlay
Microbial cytochrome c peroxidases (Ccp) have been studied for 75 years, but their physiological roles are unclear. Ccps are located in the periplasms of bacteria and the mitochondrial intermembrane spaces of fungi. In this study, Ccp is demonstrated to be a significant degrader of hydrogen peroxide in anoxic Escherichia coli Intriguingly, ccp transcription requires both the presence of H2O2 and the absence of O2 Experiments show that Ccp lacks enough activity to shield the cytoplasm from exogenous H2O2 However, it receives electrons from the quinone pool, and its flux rate approximates flow to other anaerobic electron acceptors...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28696146/heat-resistance-of-histidine-decarboxylase-from-gram-negative-histamine-producing-bacteria-in-seafood
#6
K Bjornsdottir-Butler, F A Bencsath, S McCarthy, R A Benner
Precooking of tuna is a potential critical control point (CCP) in the commercial manufacturing of canned tuna. To assess the efficacy of precooking as a CCP, an understanding of the thermal properties of histamine-producing bacteria (HPB) and their histidine decarboxylase (HDC) enzymes is required. The thermal properties of many HPB have been determined, but the thermal resistances of the HDC enzymes are unknown. The purpose of this study was to determine the D- and z-values of selected HDC enzymes to evaluate the CCP of precooking during the canning process and provide scientific data to support U...
July 11, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28693070/-expression-of-annexin-a1-in-peripheral-blood-cells-of-na%C3%A3-ve-rheumatoid-arthritis-patients-and-its-influencing-factors
#7
Y F Mei, S M Dai, H N Jia, Z G Lin, Z Y Zhang
Objective: To explore the expression of Annexin a1 (AnxA1) mRNA in peripheral blood mononuclear cells (PBMC) from Naïve rheumatoid arthritis (RA) patients and healthy controls and to investigate its influencing factors. Methods: Thirty Naïve RA patients and 36 healthy controls were recruited from the First Affiliated Hospital of Harbin Medical University between May 2013 and January 2015.All RA patients were fulfilled the classification criteria of ACR in 1987.Clinical characteristics and laboratory indexes were collected...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28692940/betulinic-acid-and-fluvastatin-exhibits-synergistic-effect-on-toll-like-receptor-4-mediated-anti-atherogenic-mechanism-in-type-ii-collagen-induced-arthritis
#8
Limi Elizabeth Mathew, Vrinda Rajagopal, Helen A
Cardiovascular disease (CVD) is a major problem during rheumatoid arthritis which leads to morbidity and mortality in arthritic patients. So the present study emphasizes combinatorial effect of Betulinic acid, a triterpenoid and fluvastatin, an HMG CoA reductase inhibitor on atherogenesis during arthritis. Arthritis was induced by bovine type II collagen dissolved in 0.01M acetic acid at a concentration of 4mg/mL and emulsified in equal volume of incomplete Freund's adjuvant. Betulinic acid (2mg/kg) and fluvastatin (5mg/kg) alone and in combination was administered orally from day 14 to 60...
July 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28691459/periodontal-microbioma-and-rheumatoid-arthritis-the-role-of-porhyromonas-gingivalis
#9
L Azzi, S Rania, R Vinci, F Spadari, F Croveri, C Scognamiglio, D Farronato, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
Rheumatoid Arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. The current study aims at evaluating the correlation between Rhematoid Arthritis (RA) and Periodontal Disease (PD), with special attention to the microbioma detected in the gums. Thirty-four patients with RD were recruited into the current study. Among rheumatic parameters, Rheumatoid Factor (RF), anti-citrullinated protein antibody (CCP), HLA-BDR1 and DAS28 were collected...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28691456/genetic-correlation-between-rheumatoid-arthritis-and-periodontal-disease-the-role-of-sex-and-il-10
#10
L Azzi, S Rania, F Spadari, R Vinci, M Manfredini, F Croveri, A Boggio, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
The chronic stimulation of the immune system due to the presence of bacterial antigens within periodontal tissues has been associated with several autoimmune diseases, like diabetes mellitus, infective endocarditis or cardiovascular atherosclerosis. The current study aims at evaluating the correlation between Rheumatoid Arthritis (RA) and Periodontal Disease (PD) with special attention to genetic polymorphisms in cytokine expression. A total number of 34 patients affected by RA were recruited. Each of them underwent haematochemical analysis and data were collected for Rheumatoid Factor (RF), Anti-Citrullinated Protein’s Antibody (CCP) and HLA-BDR1...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28672020/anti-carbamylated-protein-autoantibodies-associated-with-mortality-in-spanish-rheumatoid-arthritis-patients
#11
Laura Vidal-Bralo, Eva Perez-Pampin, Cristina Regueiro, Ariana Montes, Rosana Varela, Maria Dolores Boveda, Juan J Gomez-Reino, Antonio Gonzalez
Patients with rheumatoid arthritis (RA) have an increased mortality rate that is associated with the presence of RA-specific autoantibodies in many studies. However, the relative role of rheumatoid factor (RF), anti-CCP antibodies and the most recently established RA-autoantibodies, directed against carbamylated proteins (anti-CarP antibodies), is unclear. Here, we have assessed the role of these three antibodies in 331 patients with established RA recruited from 2001 to 2009 and followed until November 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28671267/comparison-of-facility-type-outcomes-for-oral-cavity-cancer-analysis-of-the-national-cancer-database
#12
Samuel J Rubin, Michael B Cohen, Diana N Kirke, Muhammad M Qureshi, Minh Tam Truong, Scharukh Jalisi
OBJECTIVE: Determine whether facility type effects overall survival in patients with oral cavity cancer. STUDY DESIGN: Retrospective cohort study. METHODS: Patients included in the National Cancer Database who were diagnosed with oral cavity cancer between 1998 and 2011 were included in the study. Data was stratified by facility where care was provided, including community cancer programs (CCP), comprehensive community cancer programs (CCCP), and academic centers (AC)...
July 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28668802/anticyclic-citrullinated-peptide-antibodies-and-rheumatoid-factor-as-risk-factors-for-10-year-cardiovascular-morbidity-in-patients-with-rheumatoid-arthritis-a-large-inception-cohort-study
#13
Mike L T Berendsen, Marissa C van Maaren, Elke E A Arts, Alfons A den Broeder, Calin D Popa, Jaap Fransen
OBJECTIVE: To determine whether anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) are risk factors for 10-year cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA). METHODS: Analyses were performed using data from the Nijmegen early RA inception cohort, in which patients with newly diagnosed RA, consecutively included since 1985, were regularly followed up. Anti-CCP and RF were determined at baseline (diagnosis)...
July 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28662439/interleukin-20-is-triggered-by-tlr-ligands-and-associates-with-disease-activity-in-patients-with-rheumatoid-arthritis
#14
Ladislav Šenolt, Klára Prajzlerová, Hana Hulejová, Barbora Šumová, Mária Filková, David Veigl, Karel Pavelka, Jiří Vencovský
BACKGROUND: Interleukin (IL)-20 is a pro-inflammatory cytokine that may be implicated in the pathogenesis of rheumatoid arthritis (RA). This study aimed to determine the association between IL-20 and disease activity in patients with RA. METHODS: The levels of serum and synovial fluid IL-20 were measured in patients with RA and OA. The disease activity was assessed based on the Disease Activity Score of 28 joints (DAS28). The expression of IL-20 in synovial tissue samples from patients with RA and OA were determined by immunohistochemistry...
September 2017: Cytokine
https://www.readbyqxmd.com/read/28659662/il-34-upregulated-th17-production-through-increased-il-6-expression-by-rheumatoid-fibroblast-like-synoviocytes
#15
Bing Wang, Zijian Ma, Miaomiao Wang, Xiaotong Sun, Yawei Tang, Ming Li, Yan Zhang, Fang Li, Xia Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease which is characterized by synovial inflammation and cartilage damage for which causes articular dysfunction. Activation of fibroblast-like synoviocytes (FLS) is a critical step that promotes disease progression. In this study, we aimed to explore the effect of interleukin-34 (IL-34) on RA FLS as a proinflammatory factor and IL-34-stimulated FLS on the production of Th17. We found that serum IL-34 levels were increased compared to those of the healthy controls and had positive correlations with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anticyclic citrullinated peptide (CCP) antibody accordingly...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28652209/heightened-autoantibody-immune-response-to-citrullinated-calreticulin-in-bronchiectasis-implications-for-rheumatoid-arthritis
#16
Alex Clarke, Elizabeth Perry, Clive Kelly, Anthony De Soyza, Kate Heesom, Leslie I Gold, William Ollier, David Hutchinson, P Eggleton
Calreticulin (CRT) and citrullinated (citCRT) are implicated in rheumatoid arthritis (RA) pathology. citCRT binds to RA shared epitopes (SE) on HLA-DR molecules with high affinity and triggers pro-inflammatory events in adjacent cells. The aim of the study was to detect the presence of citCRT prior to developing RA and evaluate if citCT is a target for autoantibodies in RA cohorts with and without lung disease. Antibodies were assessed by ELISA against native CRT, citCRT and general protein citrullination, in sera from 50 RA patients without lung disease, 122 bronchiectasis (BR) patients, 52 bronchiectasis patients with RA (BRRA), 87 asthma patients and 77 healthy controls (HC)...
June 24, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28648867/an-initial-investigation-into-endothelial-cc-chemokine-expression-in-the-human-rheumatoid-synovium
#17
Lisa Rump, Derek L Mattey, Oksana Kehoe, Jim Middleton
Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease. Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment. Leukocytes cross the endothelial cells (ECs) into the synovial tissue and fluid and this migration is mediated via a range of chemokines and adhesion molecules on the ECs. As important mediators of leukocyte extravasation, a number of chemokines from each of the chemokine families have been established as expressed in the RA joint...
June 22, 2017: Cytokine
https://www.readbyqxmd.com/read/28644876/effects-of-ploidy-level-and-haplotype-on-variation-of-photosynthetic-traits-novel-evidence-from-two-fragaria-species
#18
Song Gao, Qiaodi Yan, Luxi Chen, Yaobin Song, Junmin Li, Chengxin Fu, Ming Dong
To reveal the effects of ploidy level and haplotype on photosynthetic traits, we chose 175 genotypes of wild strawberries belonging to two haplotypes at two types of ploidy levels (diploidy and tetraploidy) and measured photosynthetic traits. Our results revealed that ploidy significantly affected the characteristics of light-response curves, CO2-response curves, and leaf gas exchange parameters, except intercellular CO2 concentration (Ci). Tetraploid species had a lower light saturation point (LSP) and CO2 saturation point (CSP), higher light compensation point (LCP), dark respiration (Rd), and CO2 compensation point (CCP) than diploid species...
2017: PloS One
https://www.readbyqxmd.com/read/28637873/disease-linked-mutations-in-factor-h-reveal-pivotal-role-of-cofactor-activity-in-self-surface-selective-regulation-of-complement-activation
#19
Heather Kerr, Edwin Wong, Elisavet Makou, Yi Yang, Kevin Marchbank, David Kavanagh, Anna Richards, Andrew P Herbert, Paul N Barlow
Spontaneous activation enables the complement system to respond very rapidly to diverse threats. Activation is efficiently suppressed by complement factor H (CFH) on self surfaces but not foreign surfaces. The surface selectivity of CFH, a soluble protein containing 20 CCP modules (CCPs 1-20), may be compromised by disease-linked mutations. Which of the several functions of CFH drives its self-surface selectivity remains unknown. We made human CFH mutants in Pichia pastoris. In benchmark studies of CCP-1 variants, recombinant I62-CFH (protective against age-related macular degeneration) and V62-CFH functioned equivalently, matching or outperforming plasma-derived CFH while R53H-CFH, linked to atypical haemolytic uraemic syndrome (aHUS), was defective in C3bBb decay-accelerating activity (DAA) and factor I-cofactor activity (CA)...
June 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28631342/efficacy-of-a-high-observation-protocol-in-major-head-and-neck-cancer-surgery-a-prospective-study
#20
Brittany Barber, Jeffrey Harris, Cameron Shillington, Shannon Rychlik, Joseph Dort, Michael Meier, Angela Estey, Adam Elwi, Patty Wickson, Michael Buss, David Zygun, Kal Ansari, Vincent Biron, Daniel O'Connell, Hadi Seikaly
BACKGROUND: The purpose of this study was to optimize an existing clinical care pathway (CCP) for head and neck cancer with a high-observation protocol (HOP) and to determine the effect on length of intensive care unit (ICU) admission and length of stay in hospital (LOS). METHODS: The HOP mandated initiation of spontaneous breathing trials before the conclusion of the surgery, weaning of sedation, and limiting mechanical ventilation. All patients with head and neck cancer undergoing primary surgery on the HOP were compared to a historical cohort regarding length of ICU admission, ICU readmissions, and LOS...
August 2017: Head & Neck
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