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https://www.readbyqxmd.com/read/28644876/effects-of-ploidy-level-and-haplotype-on-variation-of-photosynthetic-traits-novel-evidence-from-two-fragaria-species
#1
Song Gao, Qiaodi Yan, Luxi Chen, Yaobin Song, Junmin Li, Chengxin Fu, Ming Dong
To reveal the effects of ploidy level and haplotype on photosynthetic traits, we chose 175 genotypes of wild strawberries belonging to two haplotypes at two types of ploidy levels (diploidy and tetraploidy) and measured photosynthetic traits. Our results revealed that ploidy significantly affected the characteristics of light-response curves, CO2-response curves, and leaf gas exchange parameters, except intercellular CO2 concentration (Ci). Tetraploid species had a lower light saturation point (LSP) and CO2 saturation point (CSP), higher light compensation point (LCP), dark respiration (Rd), and CO2 compensation point (CCP) than diploid species...
2017: PloS One
https://www.readbyqxmd.com/read/28637873/disease-linked-mutations-in-factor-h-reveal-pivotal-role-of-cofactor-activity-in-self-surface-selective-regulation-of-complement-activation
#2
Heather Kerr, Edwin Wong, Elisavet Makou, Yi Yang, Kevin Marchbank, David Kavanagh, Anna Richards, Andrew P Herbert, Paul N Barlow
Spontaneous activation enables the complement system to respond very rapidly to diverse threats. Activation is efficiently suppressed by complement factor H (CFH) on self surfaces but not foreign surfaces. The surface selectivity of CFH, a soluble protein containing 20 CCP modules (CCPs 1-20), may be compromised by disease-linked mutations. Which of the several functions of CFH drives its self-surface selectivity remains unknown. We made human CFH mutants in Pichia pastoris. In benchmark studies of CCP-1 variants, recombinant I62-CFH (protective against age-related macular degeneration) and V62-CFH functioned equivalently, matching or outperforming plasma-derived CFH while R53H-CFH, linked to atypical haemolytic uraemic syndrome (aHUS), was defective in C3bBb decay-accelerating activity (DAA) and factor I-cofactor activity (CA)...
June 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28631342/efficacy-of-a-high-observation-protocol-in-major-head-and-neck-cancer-surgery-a-prospective-study
#3
Brittany Barber, Jeffrey Harris, Cameron Shillington, Shannon Rychlik, Joseph Dort, Michael Meier, Angela Estey, Adam Elwi, Patty Wickson, Michael Buss, David Zygun, Kal Ansari, Vincent Biron, Daniel O'Connell, Hadi Seikaly
BACKGROUND: The purpose of this study was to optimize an existing clinical care pathway (CCP) for head and neck cancer with a high-observation protocol (HOP) and to determine the effect on length of intensive care unit (ICU) admission and length of stay in hospital (LOS). METHODS: The HOP mandated initiation of spontaneous breathing trials before the conclusion of the surgery, weaning of sedation, and limiting mechanical ventilation. All patients with head and neck cancer undergoing primary surgery on the HOP were compared to a historical cohort regarding length of ICU admission, ICU readmissions, and LOS...
June 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/28629188/serum-biomarkers-for-discrimination-between-hepatitis-c-related-arthropathy-and-early-rheumatoid-arthritis
#4
Isabela Siloşi, Lidia Boldeanu, Viorel Biciuşcă, Maria Bogdan, Carmen Avramescu, Citto Taisescu, Vlad Padureanu, Mihail Virgil Boldeanu, Anica Dricu, Cristian Adrian Siloşi
In the present study, we aimed to estimate the concentrations of cytokines (interleukin 6, IL-6, tumor necrosis factor-α, TNF-α) and auto-antibodies (rheumatoid factor IgM isotype, IgM-RF, antinuclear auto-antibodies, ANA, anti-cyclic citrullinated peptide antibodies IgG isotype, IgG anti-CCP3.1, anti-cardiolipin IgG isotype, IgG anti-aCL) in serum of patients with eRA (early rheumatoid arthritis) and HCVrA (hepatitis C virus-related arthropathy) and to assess the utility of IL-6, TNF-α together with IgG anti-CCP and IgM-RF in distinguishing between patients with true eRA and HCVrA, in the idea of using them as differential immunomarkers...
June 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28627096/high-titer-of-anti-citrullinated-peptide-antibody-is-a-risk-factor-for-severe-carotid-atherosclerotic-plaque-in-patients-with-rheumatoid-arthritis-the-tomorrow-study
#5
Tadashi Okano, Kentaro Inui, Yuko Sugioka, Kenichi Sugioka, Yoshiki Matsumura, Shinji Takahashi, Masahiro Tada, Kenji Mamoto, Shigeyuki Wakitani, Tatsuya Koike, Hiroaki Nakamura
AIM: Cardiovascular disease is one of the complications of rheumatoid arthritis (RA). We researched the morbidity and severity of existing carotid atherosclerosis plaque and associated risk factors in patients with RA. METHOD: This study included 413 participants, including 208 patients with RA and 205 age- and sex-matched healthy volunteers. Carotid ultrasound, clinical data collection and assessment of cardiovascular risk factors were performed. Atherosclerotic plaque was defined as an intima-media thickness ≥ 1...
June 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28623821/green-biosynthesis-of-magnetic-iron-oxide-fe3o4-nanoparticles-using-the-aqueous-extracts-of-food-processing-wastes-under-photo-catalyzed-condition-and-investigation-of-their-antimicrobial-and-antioxidant-activity
#6
Jayanta Kumar Patra, Kwang-Hyun Baek
In this study, a simple, rapid, and eco-friendly green method was introduced to synthesize magnetite iron oxide nanoparticles (Fe3O4 NPs) using the aqueous extracts of two food processing wastes, namely silky hairs of corn (Zea mays L.) and outer leaves of Chinese cabbage (Brassica rapa L. subsp. pekinensis). The boiled solutions of silky hairs (MH) and outer leaves of Chinese cabbage (CCP) were used to synthesize Fe3O4 NPs under photo exposed condition. The MH-FeNPs and CCP-FeNPs synthesized via green route were characterized by UV-Vis spectroscopy, field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential thermogravimetric (TG/DTG) analysis, and vibrating sample magnetometer (VSM) analysis...
June 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28611162/a-large-chronic-pericardial-effusion-in-an-ultramarathon-runner-with-anti-ccp-positive-rheumatoid-arthritis
#7
Thomas J McClelland, Rose Penfold, Stefan Kluzek, Navraj S Nagra
Pericardial effusions arise as an extra-articular manifestation of rheumatoid arthritis (RA). Pericardial effusions are often asymptomatic, particularly in the early phase, but patients are at risk of cardiac tamponade as the effusion progresses. We discuss the case of a 40-year-old male ultramarathon runner with RA who presented with mild pleuritic chest pain and exertional dyspnoea after a recent long-haul flight. Despite a relative tachycardia, his observations were otherwise unremarkable. His blood tests revealed a C-reactive protein (CRP) of 86 mg/L and an anti-cyclic citrullinated peptide (anti-CCP) titre of 360 units/mL...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28606860/effects-of-partial-replacement-of-fish-meal-by-yeast-hydrolysate-on-complement-system-and-stress-resistance-in-juvenile-jian-carp-cyprinus-carpio-var-jian
#8
Xiang-Yang Yuan, Wen-Bin Liu, Chao Liang, Cun-Xin Sun, Yun-Fei Xue, Zu-De Wan, Guang-Zhen Jiang
A 10-week feeding trial was carried out to investigate the effects of dietary fish meal replacement by yeast hydrolysate (YH) on growth performance, complement system and stress resistance of juvenile Jian carp (Cyprinus carpio var. Jian) (initial average weight 19.44 ± 0.06 g). In the study, there were five groups: one control group was fed with a basal diet (YH0), and four treatment groups were fed with dietary fish meal replaced by 1% YH (YH1), 3% (YH3), 5% (YH5) and 7% (YH7), respectively. Each group had four replicates...
June 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28602682/scavenger-receptor-c-promotes-bacterial-clearance-in-kuruma-shrimp-marsupenaeus-japonicus-by-enhancing-hemocyte-phagocytosis-and-amp-expression
#9
Ming-Chong Yang, Hui-Ting Yang, Jing Li, Jie-Jie Sun, Wen-Jie Bi, Guo-Juan Niu, Qiang Zhang, Xiu-Zhen Shi, Xiao-Fan Zhao, Jin-Xing Wang
Scavenger receptors (SRs) comprise a large family of structurally diverse glycoproteins located on the cell membrane and function as pattern-recognition receptors (PRRs) participating in innate immunity in different species. Class C scavenger receptor (SRC) has been only identified in invertebrates and its biological functions still need to be researched. In this study, we characterized the anti-bacterial function of a SRC from kuruma shrimp Marsupenaeus japonicus (MjSRC). The mRNA level of MjSRC was up-regulated significantly in hemocytes of kuruma shrimp challenged by Vibrio anguillarum or Staphylococcus aureus...
June 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28600350/rheumatoid-arthritis-and-polymyalgia-rheumatica-occurring-after-immune-checkpoint-inhibitor-treatment
#10
Rakiba Belkhir, Sébastien Le Burel, Laetitia Dunogeant, Aurélien Marabelle, Antoine Hollebecque, Benjamin Besse, Alexandra Leary, Anne-Laure Voisin, Clémence Pontoizeau, Laetitia Coutte, Edouard Pertuiset, Gaël Mouterde, Olivier Fain, Olivier Lambotte, Xavier Mariette
OBJECTIVES: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not been well described in clinical trials. We report here cases of rheumatoid arthritis (RA) and polymyalgia rheumatica (PMR) occurring after ICI treatment. METHODS: This was a retrospective study of patients receiving an ICI in whom symptoms of arthritis or arthralgia developed and revealed a diagnosis of RA or PMR...
June 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28598775/rheumatologists-guideline-adherence-in-rheumatoid-arthritis-a-randomised-controlled-study-on-electronic-decision-support-education-and-feedback
#11
Nienke Lesuis, Ronald F van Vollenhoven, Reinier P Akkermans, Lise M Verhoef, Marlies E Hulscher, Alfons A den Broeder
OBJECTIVES: To assess the effects of education, feedback and a computerised decision support system (CDSS) versus education and feedback alone on rheumatologists' rheumatoid arthritis (RA) guideline adherence. METHODS: A single-centre, randomised controlled pilot study was performed among clinicians (rheumatologists, residents and physician assistants; n=20) working at the study centre, with a 1:1 randomisation of included clinicians. A standardized sum score (SSS) on guideline adherence was used as the primary outcome (patient level)...
June 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28589668/strongly-positive-anti-ccp-antibodies-in-patients-with-sacroiliitis-or-reactive-arthritis-post-e-%C3%A2-coli-infection-a-mini-case-series-based-review
#12
Miljyot Singh Sangha, Matthew Liam Wright, Coziana Ciurtin
We report here on four cases of patients with strongly positive anti-citrullinated cyclic peptides (anti-CCP) antibodies and clinical features of seronegative spondyloarthritis (SpA) and reactive arthritis. The four patients had various clinical presentations: one had an initial diagnosis of seropositive rheumatoid arthritis (RA) with involvement of the sacroiliac joints (similar to previous reports of the association of two diseases); one had a clinical picture of reactive arthritis following an episode of an Escherichia coli positive urinary tract infection; and two had asymmetrical sacroiliitis (SII), but no evidence of peripheral joint involvement (never reported before)...
June 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28583424/conservative-strategy-based-ensemble-surrogate-model-for-optimal-groundwater-remediation-design-at-dnapls-contaminated-sites
#13
Qi Ouyang, Wenxi Lu, Jin Lin, Wenbing Deng, Weiguo Cheng
The surrogate-based simulation-optimization techniques are frequently used for optimal groundwater remediation design. When this technique is used, surrogate errors caused by surrogate-modeling uncertainty may lead to generation of infeasible designs. In this paper, a conservative strategy that pushes the optimal design into the feasible region was used to address surrogate-modeling uncertainty. In addition, chance-constrained programming (CCP) was adopted to compare with the conservative strategy in addressing this uncertainty...
May 31, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28580908/recent-developments-in-the-ccp-em-software-suite
#14
Tom Burnley, Colin M Palmer, Martyn Winn
As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting...
June 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28580907/introducing-the-proceedings-of-the-ccp-em-spring-symposium
#15
Tom Burnley
No abstract text is available yet for this article.
June 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28578645/the-anti-migraine-effects-of-m2000-%C3%AE-d-mannuronic-acid-on-a-patient-with-rheumatoid-arthritis-as-a-case-report
#16
Mahdi Vojdanian, Hossein Ahmadi, Ahmad Reza Jamshidi, Mahdi Mahmoudi, Farhad Gharibdoost, Anis Barati, Abbas Mirshafiey
BACKGROUND: Rheumatoid arthritis (RA) and migraine are both common disorders which are caused by a faulty immune system and autonomic nervous system dysfunction, respectively. Although current treatment outlook has been shown a great improvement in these two diseases, however many side effects have been reported. CASE REPORT: We report a case of 43-years-female that has been suffered from rheumatoid arthritis for 3 years with a 6 years history of migraine. She had used different types of medication for both rheumatoid arthritis and migraine but during these 6 years no improvement was observed and even migraine progression in this patient became worse...
June 4, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28578493/nailfold-videocapillaroscopy-results-in-patients-with-rheumatoid-arthritis
#17
Sinem Sag, Mustafa Serdar Sag, Ibrahim Tekeoglu, Ayhan Kamanli, Kemal Nas, Yıldıray Aydın
We aimed to analyse the nailfold capillaryscopy findings morphologically and examine their relationship with disease activity and demographic characteristics in patients with rheumatoid arthritis. In accordance with the 2010 ACR/EULAR classification criteria, 201 patients diagnosed with Romatoiad artrit (RA) and 50 healthy controls were included. We analysed capillaroscopic abnormalities such asmegacapillaries, haemorrhages, ramifications and avascular areas in patients affected with rheumatoid arthritis. The findings in our study are as follows: in 45...
June 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28578492/anti-citrullinated-protein-antibodies-in-the-diagnosis-of-rheumatoid-arthritis-ra-diagnostic-performance-of-automated-anti-ccp-2-and-anti-ccp-3-antibodies-assays
#18
Ine Vos, Christof Van Mol, Leendert A Trouw, Michael Mahler, Jaap A Bakker, Jan Van Offel, Luc De Clerck, Tom W Huizinga
This study compares the diagnostic performance of a second generation anti-cyclic citrullinated peptide antibody (CCP2) with a third generation anti-CCP antibodies assay (CCP3), as well as the combination of both tests. Serum samples of 127 patients were analyzed. IgG anti-CCP 2 and IgM rheumatoid factor were determined by EliA™ technique on a Phadia 250 instrument (Thermo Fisher Scientific), anti-CCP3 by the Quanta Flash™ anti-CCP3 IgG kit, BIO-FLASH Rapid Response Chemiluminscence Analyzer (INOVA Diagnostics)...
June 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28578065/effect-of-salt-content-and-type-on-emulsifying-properties-of-hull-soy-soluble-polysaccharides-at-acidic-ph
#19
Dario M Cabezas, Mariana Pereira Ortiz, Jorge R Wagner, María C Porfiri
Hull soluble polysaccharide (HSPS) is a novel product consisting in a mixture of polysaccharides and proteins extracted from soy hulls by using a methodology based on the extraction of citric pectins. In this work we studied the effect of the addition of two different salts (NaCl and CaCl2) on the emulsifying properties of HSPS at acidic conditions. Low and high homogenization energies were used, obtaining coarse and fine emulsions, respectively. Mean droplet size, the stability against destabilizing processes (creaming, flocculation and coalescence) and the rheological properties of the emulsions were analyzed...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28572867/prolaris-cell-cycle-progression-test-for-localized-prostate-cancer-a-health-technology-assessment
#20
(no author information available yet)
BACKGROUND: Prostate cancer is very common and many localized tumours are non-aggressive. Determining which cancers are aggressive is important for choosing the most appropriate treatment (e.g., surgery, radiation, active surveillance). Current clinical risk stratification is reliable in forecasting the prognosis of groups of men with similar clinical and pathologic characteristics, but there is residual uncertainty at the individual level. The Prolaris cell cycle progression (CCP) test, a genomic test that estimates how fast tumour cells are proliferating, could potentially be used to improve the accuracy of individual risk assessment...
2017: Ontario Health Technology Assessment Series
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