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https://www.readbyqxmd.com/read/28935192/effect-of-priming-agents-on-shear-bond-strengths-of-resin-based-luting-agents-to-a-translucent-zirconia-material
#1
Shogo Yagawa, Futoshi Komine, Ryosuke Fushiki, Kei Kubochi, Fumiaki Kimura, Hideo Matsumura
PURPOSE: The purpose of the present study was to evaluate the effect of priming agents and artificial aging with thermocycling on shear bond strengths of two resin-based luting agents to a translucent zirconia material. METHODS: A total of 308 pairs of translucent zirconia disk specimens were divided into seven treatment groups: Alloy Primer (ALP), Clearfil Ceramic Primer Plus (CCP), Meta Fast Bonding Liner (MFB), MR. bond (MRB), Super-Bond PZ Primer Liquid B (PZB), V-Primer (VPR), and an unprimed group (UP)...
September 18, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28932306/prevalence-of-asymptomatic-arterial-hypertension-and-its-correlation-with-inflammatory-activity-in-early-rheumatoid-arthritis
#2
Ismet H Bajraktari, Sylejman Rexhepi, Idriz Berisha, Ali Lahu, Avni Kryeziu, Bastri Durmishi, Halit Bajraktari, Elton Bahtiri
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that worsens during the course of the disease and can cause disability. Early RA refers to the onset of symptoms within the past 3 months. In RA, increased levels of mediators of inflammation may cause arterial stiffness consequently leading to arterial hypertension. AIM: The aim of this cross-sectional study was to assess the prevalence of asymptomatic arterial hypertension in early RA patients as well as the correlation with parameters of inflammation...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28931886/value-of-measuring-anti-carbamylated-protein-antibodies-for-classification-on-early-arthritis-patients
#3
Cristina Regueiro, Laura Nuño, Ana M Ortiz, Diana Peiteado, Alejandro Villalba, Dora Pascual-Salcedo, Ana Martínez-Feito, Isidoro González-Alvaro, Alejandro Balsa, Antonio González
Classification of patients with rheumatoid arthritis (RA) as quickly as possible improves their prognosis. This reason motivates specially dedicated early arthritis (EA) clinics. Here, we have used 1062 EA patients with two years of follow-up to explore the value of anti-carbamylated protein (anti-CarP) antibodies, a new type of RA specific autoantibodies, for classification. Specifically, we aimed to determine whether the addition of anti-CarP antibodies to IgM rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies, which are helpful in RA classification, improves it or not...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892879/evaluation-of-anti-cyclic-citrullinated-peptide-autoantibodies-and-c-reactive-protein-in-common-autoimmune-skin-diseases-with-and-without-arthritis
#4
Bandana Kumari, Pawan Kumar, Radha Krishna Prasad Chaudhary
INTRODUCTION: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation. AIM: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. MATERIALS AND METHODS: Serum anti-CCP antibodies and CRP was measured in 50 patients of autoimmune skin disease of which 28 were of psoriasis, 12 of Systemic Lupus Erythematosus (SLE) and 10 of Pemphigus Vulgaris (PV)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28889152/anti-carbamylated-protein-antibodies-in-rheumatoid-arthritis-patients-and-their-association-with-rheumatoid-factor
#5
Maizatul A Othman, Wan Syamimee W Ghazali, Wan Zuraida W A Hamid, Kah K Wong, Nurul K Yahya
To evaluate levels of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients and to determine their association with serological parameters and disease activity. Methods: A cross-sectional study involving 105 multiethnic RA patients (48 rheumatoid factor [RF]-positive and 57 RF-negative patients) was conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia, from January 2015 to February 2016. Fifty healthy controls (HCs) were included. C-reactive protein (CRP), RF, anti-cyclic citrullinated peptide (anti-CCP) and anti-CarP antibodies were measured...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28886457/competition-derived-fret-switching-cationic-conjugated-polymer-ir-iii-complex-probe-for-thrombin-detection
#6
Chunnuan Du, Yufang Hu, Qingqing Zhang, Zhiyong Guo, Guoping Ge, Sui Wang, Chunyang Zhai, Mingshan Zhu
A novel, label-free and convenient strategy for thrombin assay has been developed based on the fluorescence resonance energy transfer (FRET) from a cationic conjugated polymer (CCP) to Ir(III) complex. The energy donor (CCP) and acceptor (Ir(III) complex) were taken into close proximity through π-π stacking interaction and electrostatic interaction, leading to the occurrence of FRET. However, the introduction of the thrombin aptamer upset the status and blocked the FRET process, but afterwards the reappearance of FRET phenomenon was confirmed by the special binding interaction between aptamer and thrombin, thus achieving the quantitative detection of thrombin...
August 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28882800/c1r-and-c1s-from-nile-tilapia-oreochromis-niloticus-molecular-characterization-transcriptional-profiling-upon-bacterial-and-ifn-%C3%AE-inductions-and-potential-role-in-response-to-bacterial-infection
#7
Xiaofang Zhong, Meng Chen, Mingmei Ding, Meiqi Zhong, Bingxi Li, Yuhong Wang, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye
The complement components C1r and C1s play a vital role in immunity with the activation of C1 complex in the classical complement pathway against pathogen infection. In this study, Nile tilapia (Oreochromis niloticus) C1r and C1s orthologs (OnC1r and OnC1s) were identified and characterized. The cDNA of OnC1r and OnC1s ORFs consisted of 1902 bp and 2100 bp of nucleotide sequence encoding polypeptides of 633 and 699 amino acids, respectively. The deduced OnC1r and OnC1s proteins both possessed CUB, EGF, CCP and SP domains, which were significantly homology to teleost...
September 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28876035/-separation-purification-and-antioxidant-activity-of-polysaccharide-from-coprinus-comatus
#8
Nü Xu, Tianzhen Zhang, Xufeng Chen, Hao Zhang, Rufu Wang
We compared the ways of deproteinization for crude polysaccharides of Coprinus comatus, and finally selected Sevage method as the optimal method. Two main fractions of Ccp-I-A and Ccp-I-B were obtained after DEAE-52 cellulose and Sephadex G-200 chromatography, both were white-floc, soluble in water, insoluble in absolute ethyl alcohol, acetone and other organic solvents. Additionally, Fehling reagent, CTAB, Sulphuric acid-carbazole, I-KI and FeCl₃ reaction were all negative. GC analysis showed Ccp-I-A was composed of mannitose, glucose and galactose in molar ratios of 2...
May 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28871954/-elevated-serum-il-25-levels-in-rheumatoid-arthritis-patients-with-bone-erosion-and-interstitial-lung-disease
#9
Jinyue Lu, Minglian DA, Yuchen Feng, Yuanyuan Liu, Sigong Zhang, Haili Shen
Objective To detect the serum levels of IL-25 and IL-17 in rheumatoid arthritis (RA) patients and investigate the potential relationship with bone erosion and concomitant interstitial lung disease (ILD). Methods The study enrolled a total of 117 RA patients and 56 healthy subjects as controls. The serum levels of IL-25 and IL-17 were determined by ELISA, and rheumatoid factor (RF) was detected by turbidimetric immunoassay, anticyclic citrullinated peptide (anti-CCP) antibody as well as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also tested...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28871190/new-insights-about-functional-and-cross-reactive-properties-of-antibodies-generated-against-recombinant-tbpbs-of-haemophilus-parasuis
#10
Bibiana Martins Barasuol, João Antônio Guizzo, Jamie Elisabeth Fegan, Sonia Martínez-Martínez, Elías Fernando Rodríguez-Ferri, César Bernardo Gutiérrez-Martín, Luiz Carlos Kreutz, Anthony Bernard Schryvers, Rafael Frandoloso
Vaccines have become fundamental in the control and elimination of Glässer Disease, a systemic disease of pigs caused by Haemophilus parasuis. The classic vaccines available for prevention of this infection were developed without a robust knowledge about host immunological mechanisms. In this study, we demonstrated the presence of cross-reactive epitopes on both the N-lobe and C-lobe of variants of transferrin binding protein B (TbpBs) expressed on the surface of 6 virulent serovars of H. parasuis. Antibodies against TbpB-derived antigens were capable of increasing the phagocytic capacity of neutrophils and were also capable of blocking porcine transferrin from binding to TbpB...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870033/-the-expression-and-clinical-significance-of-proprotein-convertase-subtilisin-kexin-9-in-rheumatoid-arthritis
#11
Q Du, X J Yu, H J Li, S Q Guan, Z Y Zhang, Y F Mei
Objective: To assess the expression and significance of proprotein convertase subtilisin kexin 9 (PCSK9) in patients with rheumatoid arthritis (RA). Methods: Sixty-five RA patients and forty-seven healthy controls were recruited in this study. The body mass index (BMI) and serum total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL), lipoprotein a, low density lipoprotein(LDL), very low density lipoprotein(VLDL), apolipoprotein A(ApoA), apolipoprotein B(ApoB) and the ratio of LDL-C/HDL-C were tested...
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28865493/high-titers-of-both-rheumatoid-factor-and-anti-ccp-antibodies-at-baseline-in-patients-with-rheumatoid-arthritis-are-associated-with-increased-circulating-baseline-tnf-level-low-drug-levels-and-reduced-clinical-responses-a-post-hoc-analysis-of-the-rising-study
#12
Tsutomu Takeuchi, Nobuyuki Miyasaka, Takashi Inui, Toshiro Yano, Toru Yoshinari, Tohru Abe, Takao Koike
BACKGROUND: Although both rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (anti-CCP) are useful for diagnosing rheumatoid arthritis (RA), the impact of these autoantibodies on the efficacy of tumor necrosis factor (TNF) inhibitors has been controversial. The aim of this post hoc analysis of a randomized double-blind study (the RISING study) was to investigate the influences of RF and anti-CCP on the clinical response to infliximab in patients with RA. METHODS: Methotrexate-refractory patients with RA received 3 mg/kg of infliximab from weeks 0 to 6 and then 3, 6, or 10 mg/kg every 8 weeks from weeks 14 to 46...
September 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28865482/decrease-in-bone-mineral-density-during-three-months-after-diagnosis-of-early-rheumatoid-arthritis-measured-by-digital-x-ray-radiogrammetry-predicts-radiographic-joint-damage-after-one-year
#13
Michael Ziegelasch, Kristina Forslind, Thomas Skogh, Katrine Riklund, Alf Kastbom, Ewa Berglin
BACKGROUND: Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a computerized technique to estimate bone mineral density (BMD) from hand radiographs. The aim of this study was to evaluate whether decrease in BMD of the hands (BMD loss), as determined by DXR 3 months after diagnosis, predicts radiographic joint damage after 1 and 2 years in patients with early RA...
September 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28856160/mortality-and-cardiovascular-complications-in-older-complex-chronic-patients-with-type-2-diabetes
#14
J L Clua-Espuny, M A González-Henares, M L L Queralt-Tomas, W Campo-Tamayo, E Muria-Subirats, A Panisello-Tafalla, J Lucas-Noll
AIMS/INTRODUCTION: Determining the prevalence of diabetes and its cardiovascular complications and all-cause mortality in older chronic complex patients. MATERIALS AND METHODS: We carried out a multicenter retrospective study and included a randomized sample of 932 CCP people. We assessed the prevalence of diabetes according to World Health Organization criteria. Data included demographics and functional, comorbidity, cognitive, and social assessment. RESULTS: The prevalence of diabetes was 53% and average age 81...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28855496/a-retrospective-study-the-significance-of-combined-testing-of-serum-markers-for-diagnosis-of-rheumatoid-arthritis
#15
Fangxiang Mu, Hong Wu, Yong Wang
BACKGROUND There have been few studies on the value of various antibody combinations in rheumatoid arthritis (RA) diagnosis, and a lack of studies with large sample sizes, especially in the Chinese population. This study retrospectively evaluated the diagnostic value of a combined assay of five auto-antibodies [anti-cyclic citrullinated peptide (anti-CCP), anti-keratin (AKA), anti-RA 33, glucose-6-phosphate isomerase (GPI), and rheumatoid factor (RF)] for RA. MATERIAL AND METHODS Data were obtained from 5,725 patients with rheumatic diseases in Southwest Hospital of Chongqing from 2011 to 2014...
August 31, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28841378/insights-into-the-dynamics-and-dissociation-mechanism-of-a-protein-redox-complex-using-molecular-dynamics
#16
Scott A Hollingsworth, Brian D Nguyen, Georges Chreifi, Anton P Arce, Thomas L Poulos
Leishmania major peroxidase (LmP) is structurally and functionally similar to the well-studied yeast Cytochrome c peroxidase (CCP). A recent Brownian dynamics study showed that L. major Cytochrome c (LmCytc) associates with LmP by forming an initial complex with the N-terminal helix A of LmP, followed by a movement toward the electron transfer (ET) site observed in the LmP-LmCytc crystal structure. Critical to forming the active electron transfer complex is an intermolecular Arg-Asp ion pair at the center of the interface...
September 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28837847/renoprotective-effect-of-chinese-chive-polysaccharides-in-adenine-induced-chronic-renal-failure
#17
Qiang-Ming Li, Xue-Qiang Zha, Chao-Qun Lu, Li-Hua Pan, Jian-Ping Luo
In this work, we investigated the effect of Chinese chive polysaccharides (CCP) on renal function in mice with adenine-induced chronic renal failure (CRF). Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of CCP in a dose-dependent manner. When CCP dosage reached 200mg/kg/day, the area of renal pathological damage was decreased by 59...
August 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28837666/tumor-necrosis-factor-%C3%AE-blockade-treatment-decreased-cd154-cd40-ligand-expression-in-rheumatoid-arthritis
#18
Chien-Hsueh Tung, Ming-Chi Lu, Ning-Sheng Lai, Shu-Fen Wu
CONTEXTS: CD154 (commonly referred to as CD40-ligand) is a critical T cell factor that participates in the pathogenesis of autoimmune and is over-expressed in rheumatoid arthritis (RA). TNF-α blockade treatment had dramatic efficacy in RA. OBJECTIVE: To investigate whether TNF-α blockade treatment can inhibit CD154 expression in RA. METHODS: Blood samples were collected from 33 patients with rheumatoid arthritis before and 3 months after TNF-α blockade treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28837415/the-efficacy-of-abatacept-focusing-on-anti-ccp-antibody-in-japanese-patients-with-rheumatoid-arthritis-for-104-weeks
#19
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Ryo Hiroshima, Kosei Kawakami, Naoko Koenuma, Mina Ishibashi, Shigeki Momohara
No abstract text is available yet for this article.
August 24, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28816989/disease-duration-of-rheumatoid-arthritis-is-a-predictor-of-vascular-stiffness-a-cross-sectional-study-in-patients-without-known-cardiovascular-comorbidities-a-strobe-compliant-article
#20
Mónica Vázquez-Del Mercado, Eduardo Gomez-Bañuelos, Efrain Chavarria-Avila, Ernesto Cardona-Muñoz, Carlos Ramos-Becerra, Adrián Alanis-Sanchez, David Cardona-Muller, Fernando Grover-Paez, Felipe de J Perez-Vazquez, Rosa-Elena Navarro-Hernandez, Jorge M Valadez-Soto, Adan A Saldaña-Millan, Lorena Gonzalez-Rosas, Gabriel Ramos-Lopez, Marcelo H Petri, Magnus Bäck
The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities.Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies...
August 2017: Medicine (Baltimore)
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