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https://www.readbyqxmd.com/read/27904840/surgical-experience-on-chronic-constrictive-pericarditis-in-african-setting-review-of-35-years-experience-in-cote-d-ivoire
#1
Koffi Herve Yangni-Angate, Yves Tanauh, Christophe Meneas, Florent Diby, Anicet Adoubi, Manga Diomande
BACKGROUND: Surgical experience with chronic constrictive pericarditis (CCP) is rarely documented in Africa; the aim of this study is therefore to review our African experience with CCP from 1977 to 2012 in terms of clinical and surgical outcomes and risk factors of early death after pericardiectomy. METHODS: This retrospective study is related to 120 patients with CCP; there were 72 men and 48 women with an average age at 28.8±10.4 years standard deviation (SD) (8-51 years)...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27898981/macular-features-in-retinitis-pigmentosa-correlations-among-ganglion-cell-complex-thickness-capillary-density-and-macular-function
#2
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Paolo Carpineto, Leonardo Mastropasqua
Purpose: To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). Methods: Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27894974/ccp-score-might-improve-the-current-risk-assessment-in-newly-diagnosed-prostate-cancer-patients
#3
Marco Oderda, Gabriele Cozzi, Lorenzo Daniele, Anna Sapino, Stefania Munegato, Giuseppe Renne, Ottavio De Cobelli, Paolo Gontero
OBJECTIVE: To assess whether cell-cycle progression (CCP)-score (Prolaris) can improve the current risk assessment in newly diagnosed PCa patients. CCP-score is a well validated prognostic assay predictive of PCa death, biochemical recurrence (BCR) and progression. METHODS: We evaluated CCP-score at biopsy in 52 patients newly diagnosed with PCa who underwent radical prostatectomy. CCP-score was calculated as average RNA expression of 31 CCP genes, normalized to 15 housekeeping genes...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27888598/adult-onset-still-s-disease-with-different-antibodies-a-case-report-and-review-of-literature
#4
Maryam Mobini, Roya Ghasemian, Fatemeh Zameni
 Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. There is not currently any specific serological markers for AOSD , and  diagnosis still relying on the exclusion of other likely diagnoses. Yamaguchi's criteria are used as a diagnostic criterion which contains negative serologic markers for other collagen vascular diseases including systemic lupus erythematosus and rheumatoid arthritis. Here we report a 28-year-old woman with arthralgia, fever, rash, leukocytosis, lymphadenopathy, sore throat, abnormal liver function and negative rheumatoid factor and ANA but  seropositive for anti-CCP, anti-dsDNA, and C-ANCA...
October 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27886444/incidence-and-classification-of-cutaneous-manifestations-in-rheumatoid-arthritis
#5
Mirjana Ziemer, Anne-Katrin Müller, Gert Hein, Peter Oelzner, Peter Elsner
BACKGROUND AND OBJECTIVE: There have only been few studies examining rheumatoid arthritis (RA)-related skin manifestations in larger patient populations. Herein, we present current data on the prevalence and spectrum of cutaneous lesions in RA, addressing disease activity scores, anti-CCP antibodies as well as novel pharmacological approaches. PATIENTS AND METHODS: Between November 2006 and July 2007, 214 patients with RA treated at the Division of Rheumatology, University Hospital Jena, Germany, were prospectively examined...
November 25, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27884523/the-anthroposphere-as-an-anticipatory-system-open-questions-on-steering-the-climate
#6
Rocco Scolozzi, Davide Geneletti
Climate change research and action counteracting it affect everyone and would involve cross-societal transformations reshaping the anthroposphere in its entirety. Scrutinizing climate-related science and policies, we recognize attempts to steer the evolution of climate according to expected (or modelled) futures. Such attempts would turn the anthroposphere into a large "anticipatory system", in which human society seeks to anticipate and, possibly, to govern climate dynamics. The chief aim of this discussion paper is to open a critical debate on the climate change paradigm (CCP) drawing on a strategic and systemic framework grounded in the concept of anticipatory system sensu Rosen (1991)...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27864055/gastroprotective-effect-and-chemical-characterization-of-a-polysaccharide-fraction-from-leaves-of-croton-cajucara
#7
Adamara M Nascimento, Daniele Maria-Ferreira, Evana Figueiredo J de Souza, Lauro M de Souza, Guilherme L Sassaki, Marcello Iacomini, Maria Fernanda de P Werner, Thales R Cipriani
Croton cajucara Benth. is a tree from the Amazon Forest, where it is known as sacaca. Its leaves and barks are used in medicinal preparations to treat different diseases, including gastric ulcers. The crude polysaccharide fraction (CCP), obtained from the hot aqueous extract of C. cajucara leaves, was able to promote gastroprotection on an ethanol induced gastric ulcer model. Therefore, a bioguided fractionation was performed to isolate the active polysaccharide fraction. After freezing-thawing, ultrafiltration and dialyses at 100, 50, and 25kDa cut-off membranes, fraction 25R was obtained...
November 15, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27860106/protein-surface-mimetics-understanding-how-ruthenium-tris-bipyridines-interact-with-proteins
#8
Sarah H Hewitt, Maria H Filby, Ed Hayes, Lars T Kuhn, Arnout P Kalverda, Michael E Webb, Andrew John Wilson
Protein surface mimetics achieve high affinity binding by exploiting a scaffold to project binding groups over a large area of solvent exposed protein surface to make multiple co-operative non-covalent interactions. Such recognition is a pre-requisite for competitive/ orthosteric inhibition of protein-protein interactions (PPIs). This paper describes biophysical and structural studies on ruthenium(II) tris(bipyridine) surface mimetics that recognize cytochrome (cyt) c and inhibit the cyt c/ cyt c peroxidase (CCP) PPI...
November 17, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27859022/igg1-and-igg4-anti-ccp-associate-with-shared-epitope-whereas-igg2-anti-ccp-associates-with-smoking-in-patients-with-recent-onset-rheumatoid-arthritis-the-swedish-tira-project
#9
Klara Martinsson, Anders Johansson, Alf Kastbom, Thomas Skogh
Given the possible importance of anti-citrullinated peptide/protein antibodies (ACPA) for initiation and progression of rheumatoid arthritis (RA), extended knowledge about the different isotypes and subclasses are important. In the present study we analysed the IgG subclasses regarding reactivity against citrullinated peptides (anti-CCP) among 504 clinically well-characterized patients with recent-onset RA in relation to smoking habits, shared epitope (SE) status, and IgA and pan IgG anti-CCP antibodies. All patients, regardless of pan IgG anti-CCP status, were analysed for IgG1-4 CCP reactivity...
November 17, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27848057/the-additional-benefit-of-ultrasonography-to-2010-acr-eular-classification-criteria-when-diagnosing-rheumatoid-arthritis-in-the-absence-of-anti-cyclic-citrullinated-peptide-antibodies
#10
Lanlan Ji, Xuerong Deng, Yan Geng, Zhibo Song, Zhuoli Zhang
The aim of this study was to assess the benefit of ultrasonography (US) contributing to 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria in diagnosing rheumatoid arthritis (RA), when anti-citrullinated protein (CCP) antibody and radiographic erosions are absent. Ninety-four patients suffering from arthritis of at least one joint in hands, symptom duration of less than 2 years, normal radiographs at baseline, and negative anti-CCP had 22 joint US assessments and were followed prospectively for at least 12 months...
November 15, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27821398/participation-of-a-coordinating-center-pharmacy-in-a-multicenter-international-study
#11
Jihyun Esther Jeon, Janet Mighty, Karen Lane, Nichol McBee, Ryan Majkowski, Steven Mayo, Daniel Hanley
PURPOSE: The activities of a coordinating center pharmacy (CCP) supporting a multicenter, international clinical trial are described. SUMMARY: Serving in a research support role comparable to that of a commercial clinical trial supply company, a CCP within the Johns Hopkins Hospital Investigational Drug Service (JHH IDS) uses its management expertise and infrastructure to support multicenter trials, such as the recently completed Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage, Phase III (CLEAR III) trial...
November 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27800636/diagnostic-value-of-autoantibodies-combined-detection-for-rheumatoid-arthritis
#12
Pingping Sun, Wanhai Wang, Ling Chen, Nan Li, Xianchun Meng, Jing Bian, Jingjing Yang, Xu'na Wang, Weitao Zhu, Liang Ming
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, inflammatory and autoimmune disease, there are many autoantibodies produced during disease progression in the patients' serum, and this work is to select a best detection scheme for RA diagnosis. METHODS: Autoantibody levels including rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP), mutated citrullinated vimentin (MCV), anti-keratin antibodies(AKA), anti-perinuclear factor (APF), and Ig heavy chain binding protein (BIP), were measured, and the sensitivity, specificity, predictive values, accuracy, and Youden's index of different combining forms were all calculated in RA patients, disease, and healthy control group...
November 1, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27796662/genetic-variant-of-il-10ra-and-susceptibility-to-rheumatoid-arthritis-in-a-chinese-population
#13
Xiao-Ke Yang, Peng Li, Song Li, Chao Zhang, Bao-Zhu Li, Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye
The aim of this study was to investigate the relationship between the single-nucleotide polymorphisms (SNPs) of interleukin 10 alpha receptor (IL10RA) gene and rheumatoid arthritis (RA) in a Chinese population. We examined 533 RA patients and 958 subjects as a control group. Three IL-10RA SNPs (rs9610, rs2229113 and rs3135932) were genotyped using TaqMan genotyping assays on Fluidigm 192.24 system. The IL-10RA rs9610 A allele was increased in patient group compared with control subjects (OR = 1.232, 95 % CI = 1...
October 29, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27794412/prediction-of-distant-recurrence-in-resected-stage-i-and-ii-lung-adenocarcinoma
#14
Beatrice Aramini, Christian Casali, Alessandro Stefani, Stefania Bettelli, Susanne Wagner, Zaina Sangale, Elisha Hughes, Jerry S Lanchbury, Antonino Maiorana, Uliano Morandi
OBJECTIVES: Optimal procedures for adjuvant treatment and post-surgical surveillance of resected non-small-cell lung cancer remain under discussion. Pathological features are the main determinant of follow-up therapy but have limited ability to identify patients at risk of recurrence. Increasingly, molecular markers are incorporated into clinical decision-making, including measures of tumor growth. The CCP score is a quantitative, molecular measure of proliferation derived from the RNA expression of 31 cell cycle genes and a component of the molecular prognostic score (mPS)...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27790341/anti-cyclic-citrullinated-peptide-antibodies-in-children-with-juvenile-idiopathic-arthritis
#15
Mohamed Hamooda, Hala Fouad, Nermeen Galal, Nadia Sewelam, Dina Megahed
AIM: The purpose of present study was to access the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with Juvenile Idiopathic Arthritis (JIA), and to investigate the clinical significance and diagnostic value of the anti-CCP antibodies in correlation with age, sex & activity. METHODS: This case-control study was performed on 50 patients with JIA in addition to 40 sex and age-matched children as a control group. The participants were recruited from rheumatology Outpatient Clinic of Cairo University Specialized Pediatric Hospital...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27789050/-assessment-of-the-effectiveness-of-a-proactive-and-integrated-healthcare-programme-for-chronic-complex-patients
#16
Jordi Coderch, Xavier Pérez-Berruezo, Inma Sánchez-Pérez, Elvira Sánchez, Pere Ibern, Marc Pérez, Marc Carreras, José M Inoriza
OBJECTIVE: To assess the effectiveness of a proactive and integrated care programme to adjust the use of health resources by chronic complex patients (CCP) identified as potential high consumers according to a predictive model based on prior use and morbidity. METHODS: Randomized controlled clinical trial with three parallel groups of CCP: a blinded control group (GC), usual care; a partial intervention group (GIP) reported in the EMR; a total intervention group (GIT), also reported to primary care (PC)...
October 24, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27788684/protein-oxidation-nitration-and-glycation-biomarkers-for-early-stage-diagnosis-of-osteoarthritis-of-the-knee-and-typing-and-progression-of-arthritic-disease
#17
Usman Ahmed, Attia Anwar, Richard S Savage, Paul J Thornalley, Naila Rabbani
BACKGROUND: There is currently no blood-based test for detection of early-stage osteoarthritis (OA) and the anti-cyclic citrullinated peptide (CCP) antibody test for rheumatoid arthritis (RA) has relatively low sensitivity for early-stage disease. Morbidity in arthritis could be markedly decreased if early-stage arthritis could be routinely detected and classified by clinical chemistry test. We hypothesised that damage to proteins of the joint by oxidation, nitration and glycation, and with signatures released in plasma as oxidized, nitrated and glycated amino acids may facilitate early-stage diagnosis and typing of arthritis...
October 27, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27774509/primary-hyperparathyroidism-and-pancreatitis-a-rare-association-with-multiple-facets
#18
I Diallo, C A Fall, B Ndiaye, M Mbaye, I Diedhiou, A R Ndiaye, P S Diawara, F Fall, P S Mbaye, S B Gning
Primary hyperparathyroidism (PHPT) is rarely associated with the occurrence of acute or chronic pancreatitis. Hypercalcemia plays a major role in the pathogenesis. We report five cases of pancreatitis revealing PHPT. Patients and Methods. This is a retrospective study of 4 years, including all patients admitted to intensive care unit or gastroenterology department, for an acute or chronic pancreatitis revealing primary hyperparathyroidism. Results. We included 5 patients, all female, with mean age 54 years [40-76 years]...
2016: International Scholarly Research Notices
https://www.readbyqxmd.com/read/27766762/a-selective-near-infrared-fluorescent-probe-for-in-vivo-imaging-of-thiophenols-from-a-focused-library
#19
Lin Yuan, Yue Pan, Tian-Bing Ren, Dan Cheng, Ze-Bing Zeng, Xiao-Bing Zhang
Thiophenols are highly toxic industrial materials that once released, will accumulate in environment and ultimately into human bodies, causing serious health problems. To achieve their selective and sensitive detection, herein a novel near-infrared fluorescent probe CCP-1 from a focused library was developed for thiophenol species. Our studies show that CCP-1 displays a thiophenol-triggered 28-fold fluorescence intensity enhancement at 706 nm, with a detection limit of 34 nM observed. It is also able to differentiate thiophenols from various other thiol-containing analytes including hydrogen sulfide, hydrogen persulfide and aliphatic thiols...
October 21, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27765955/fluorescence-visual-detection-of-herbal-product-substitutions-at-terminal-herbal-markets-by-ccp-based-fret-technique
#20
Chao Jiang, Yuan Yuan, Guang Yang, Yan Jin, Libing Liu, Yuyang Zhao, Luqi Huang
Inaccurate labeling of materials used in herbal products may compromise the therapeutic efficacy and may pose a threat to medicinal safety. In this paper, a rapid (within 3 h), sensitive and visual colorimetric method for identifying substitutions in terminal market products was developed using cationic conjugated polymer-based fluorescence resonance energy transfer (CCP-based FRET). Chinese medicinal materials with similar morphology and chemical composition were clearly distinguished by the single-nucleotide polymorphism (SNP) genotyping method...
October 21, 2016: Scientific Reports
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