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https://www.readbyqxmd.com/read/29862835/the-diagnosis-of-hereditary-angioedema-family-caregivers-experiences
#1
José Granero-Molina, Francisco Sánchez-Hernández, Cayetano Fernández-Sola, María Del Mar Jiménez-Lasserrotte, Laura Helena Antequera-Raynal, José Manuel Hernández-Padilla
The aim of this study was to understand the experiences of family caregivers in the process of diagnosing hereditary angioedema. An interpretive and qualitative research methodology based on Gadamer's philosophical hermeneutics was carried out. Data collection took place between May 2015 and August 2016 and included a focus group and in-depth interviews with 16 family caregivers. Two themes define the experiences of family caregivers: "Family life focuses on identifying the problem" and "Discovering and coping with a complex diagnosis...
June 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29802788/treatment-with-non-selective-beta-blockers-affects-the-systemic-inflammatory-response-to-bacterial-dna-in-patients-with-cirrhosis
#2
Paula Gimenez, Irma Garcia-Martinez, Rubén Francés, Jose Manuel Gonzalez-Navajas, Montserrat Mauri, Rocío Alfayate, Susana Almenara, Cayetano Miralles, Jose M Palazon, Fernando Carnicer, Sonia Pascual, José Such, José F Horga, Pedro Zapater
BACKGROUND AND AIMS: The use of non-selective beta-blockers has been associated with lower rates of infection and reduced infection-associated morbidity in patients with cirrhosis. However, it is unknown if these drugs modify the systemic inflammatory response to circulating bacterial DNA. METHODS: Sixty-three patients with cirrhosis were included during an episode of decompensation by ascites. Thirty of those patients were on beta-blockers. Blood samples were obtained after each patient had been in the supine position for at least 30 minutes in a quiet atmosphere...
May 26, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29740900/adjusting-oral-oxybutynin-medication-for-hyperhidrosis-to-reflect-seasonal-temperature-variations
#3
Javier Del Boz, José Francisco Millán-Cayetano, Pablo García-Montero, Cristina García-Harana, Francisco Rivas-Ruiz, Magdalena de Troya-Martín
Most studies of oral oxybutynin (OOx) for the treatment of hyperhidrosis (HH) have assumed a stable treatment protocol, without taking into account adverse effects (AE) or seasonal variations in temperature. The objective is to evaluate adjusting the dose of OOx according to the time of year. Prospective study of patients who began OOx for HH between 2007 and 2017, and maintained treatment for at least 1 year, with a progressively increasing dose was performed. All patients were recommended to vary the dose of medication according to the time of year...
May 8, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29712734/centrobin-is-essential-for-c-tubule-assembly-and-flagellum-development-in-drosophila-melanogaster-spermatogenesis
#4
Jose Reina, Marco Gottardo, Maria G Riparbelli, Salud Llamazares, Giuliano Callaini, Cayetano Gonzalez
Centrobin homologues identified in different species localize on daughter centrioles. In Drosophila melanogaster sensory neurons, Centrobin (referred to as CNB in Drosophila ) inhibits basal body function. These data open the question of CNB's role in spermatocytes, where daughter and mother centrioles become basal bodies. In this study, we report that in these cells, CNB localizes equally to mother and daughter centrioles and is essential for C-tubules to attain the right position and remain attached to B-tubules as well as for centrioles to grow in length...
April 30, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29673937/evaluating-riparian-solutions-to-multiple-stressor-problems-in-river-ecosystems-a-conceptual-study
#5
REVIEW
Christian K Feld, Maria Rosário Fernandes, Maria Teresa Ferreira, Daniel Hering, Steve J Ormerod, Markus Venohr, Cayetano Gutiérrez-Cánovas
Rivers are among the most sensitive of all ecosystems to the effects of global change, but options to prevent, mitigate or restore ecosystem damage are still inadequately understood. Riparian buffers are widely advocated as a cost-effective option to manage impacts, but empirical evidence is yet to identify ideal riparian features (e.g. width, length and density) which enhance ecological integrity and protect ecosystem services in the face of catchment-scale stressors. Here, we use an extensive literature review to synthesise evidence on riparian buffer and catchment management effects on instream environmental conditions (e...
August 1, 2018: Water Research
https://www.readbyqxmd.com/read/29559307/cough-frequency-during-treatment-associated-with-baseline-cavitary-volume-and-proximity-to-the-airway-in-pulmonary-tb
#6
Alvaro Proaño, David P Bui, José W López, Nancy M Vu, Marjory A Bravard, Gwenyth O Lee, Brian H Tracey, Ziyue Xu, Germán Comina, Eduardo Ticona, Daniel J Mollura, Jon S Friedland, David A J Moore, Carlton A Evans, Philip Caligiuri, Robert H Gilman
BACKGROUND: Cough frequency, and its duration, is a biomarker that can be used in low-resource settings without the need of laboratory culture and has been associated with transmission and treatment response. Radiologic characteristics associated with increased cough frequency may be important in understanding transmission. The relationship between cough frequency and cavitary lung disease has not been studied. METHODS: We analyzed data in 41 adults who were HIV negative and had culture-confirmed, drug-susceptible pulmonary TB throughout treatment...
March 17, 2018: Chest
https://www.readbyqxmd.com/read/29554777/multiple-stressor-effects-on-biological-quality-elements-in-the-ebro-river-present-diagnosis-and-predicted-responses
#7
Albert Herrero, Cayetano Gutiérrez-Cánovas, Olga Vigiak, Stefanie Lutz, Rohini Kumar, David Gampe, Verena Huber-García, Ralf Ludwig, Ramon Batalla, Sergi Sabater
Multiple abiotic stressors affect the ecological status of water bodies. The status of waterbodies in the Ebro catchment (NE Spain) is evaluated using the biological quality elements (BQEs) of diatoms, invertebrates and macrophytes. The multi-stressor influence on the three BQEs was evaluated using the monitoring dataset available from the catchment water authority. Nutrient concentrations, especially total phosphorus (TP), affected most of the analyzed BQEs, while changes in mean discharge, water temperature, or river morphology did not show significant influences...
July 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29525795/research-trends-in-carrion-s-disease-in-the-last-60-years-a-bibliometric-assessment-of-latin-american-scientific-production
#8
Carlos Culquichicón, Emanuel Ramos-Cedano, Luis Helguero-Santin, Roberto Niño-Garcia, Alfonso J Rodriguez-Morales
Carrion's disease is a major re-emerging and occupational health disease. This bibliometric study aimed to evaluate scientific production on this disease both globally and in Latin America. SCI-E, MEDLINE/GoPubMed, SCOPUS, ScIELO, and LILACS databases were searched for Carrion's disease-related articles. They were classified according to publication year, type, city and institution of origin, international cooperation, scientific journal, impact factor, publication language, author(s), and H-index. There were 170 articles in SCI-E...
March 1, 2018: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29467187/-drosophila-larval-brain-neoplasms-present-tumour-type-dependent-genome-instability
#9
Fabrizio Rossi, Camille Stephan-Otto Attolini, Jose Luis Mosquera, Cayetano Gonzalez
Single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) are found at different rates in human cancer. To determine if these genetic lesions appear in Drosophila tumors we have sequenced the genomes of 17 malignant neoplasms caused by mutations in l(3)mbt , brat , aurA , or lgl We have found CNVs and SNPs in all the tumors. Tumor-linked CNVs range between 11 and 80 per sample, affecting between 92 and 1546 coding sequences. CNVs are in average less frequent in l(3)mbt than in brat lines. Nearly half of the CNVs fall within the 10 to 100Kb range, all tumor samples contain CNVs larger that 100 Kb and some have CNVs larger than 1Mb...
March 28, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29459803/-prevalence-and-severity-of-the-hepatopulmonar-syndrome-in-patients-with-liver-cirrhosis-attended-at-cayetano-heredia-hospital-between-january-and-december-2015
#10
Vanessa Valenzuela Granados, Soledad Violeta Calle Lunarejo, Jhosmell Walter Bautista Tiburcio, Héctor Daniel Villa Alvarado, Aida Del Carmen Rotta Rotta D, Karla Tafur Bances, José Luis Pinto Valdivia, Jorge Huerta-Mercado Tenorio, José Rojas Vilca
INTRODUCTION: The hepatopulmonary syndrome (HPS) is a rare complication of liver cirrhosis (LC) which significantly diminishes the quality of life for people who suffer. OBJECTIVES: To determine the prevalence and severity of HPS in patients with CH treated at the Cayetano Heredia (HCH) Hospital in the period from January to December 2015. MATERIALS AND METHODS: Cross-sectional study with sample size needed to determine the point prevalence calculated in 297 patients...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29452968/analysis-and-description-of-disease-specific-quality-of-life-in-patients-with-anal-fistula
#11
Manuel Ferrer-Márquez, Natalia Espínola-Cortés, Ángel Reina-Duarte, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla
INTRODUCTION: In patients diagnosed with anal fistula, knowing the quality of life specifically related to the disease can help coloproctology specialists to choose the most appropriate therapeutic strategy for each case. The aim of our study is to analyzse and describe the factors related to the specific quality of life in a consecutive series of patients diagnosed with anal fistula. METHODS: Observational, cross-sectional study carried out from March 2015 to February 2017...
April 2018: Cirugía Española
https://www.readbyqxmd.com/read/29435315/fluid-resuscitation-with-lactated-ringer-s-solution-vs-normal-saline-in-acute-pancreatitis-a-triple-blind-randomized-controlled-trial
#12
Enrique de-Madaria, Iván Herrera-Marante, Verónica González-Camacho, Laia Bonjoch, Noé Quesada-Vázquez, Isabel Almenta-Saavedra, Cayetano Miralles-Maciá, Nelly G Acevedo-Piedra, Manuela Roger-Ibáñez, Claudia Sánchez-Marin, Rosa Osuna-Ligero, Ángel Gracia, Pere Llorens, Pedro Zapater, Vikesh K Singh, Rocío Moreu-Martín, Daniel Closa
Background: Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective: The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods: We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29426198/modelling-the-effects-of-climate-and-land-use-change-on-the-hydrochemistry-and-ecology-of-the-river-wye-wales
#13
Gianbattista Bussi, Paul G Whitehead, Cayetano Gutiérrez-Cánovas, José L J Ledesma, Steve J Ormerod, Raoul-Marie Couture
Interactions between climate change and land use change might have substantial effects on aquatic ecosystems, but are still poorly understood. Using the Welsh River Wye as a case study, we linked models of water quality (Integrated Catchment - INCA) and climate (GFDL - Geophysical Fluid Dynamics Laboratory and IPSL - Institut Pierre Simon Laplace) under greenhouse gas scenarios (RCP4.5 and RCP8.5) to drive a bespoke ecosystem model that simulated the responses of aquatic organisms. The potential effects of economic and social development were also investigated using scenarios from the EU MARS project (Managing Aquatic Ecosystems and Water Resources under Multiple Stress)...
June 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29421939/social-support-for-female-sexual-dysfunction-in-fibromyalgia
#14
José Granero-Molina, Tamara María Matarín Jiménez, Carmen Ramos Rodríguez, José Manuel Hernández-Padilla, Adelaida María Castro-Sánchez, Cayetano Fernández-Sola
The aim of this study is to describe and understand experiences related to social support for women with fibromyalgia who suffer from sexual dysfunction. An interpretive qualitative research methodology based on Gadamer's philosophical hermeneutics was used. Data collection included a focus group and in-depth interviews with 13 women who averaged 44.8 years of age and 14.3 years since being diagnosed with fibromyalgia. Data were analyzed using Fleming's method and two themes were identified: "searching for understanding in socio-family support" and "lack of formal support regarding fibromyalgia patient's sexuality...
March 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29421848/characterization-conservation-and-loss-of-dignity-at-the-end-of-life-in-the-emergency-department-a-qualitative-protocol
#15
Cayetano Fernández-Sola, José Granero-Molina, María Del Mar Díaz-Cortés, Francisca Rosa Jiménez-López, Pablo Roman-López, Encarnación Saez-Molina, Cayetano José Aranda-Torres, José María Muñoz-Terrón, María Paz García-Caro, José Manuel Hernández-Padilla
AIMS: To explore and understand the experiences of terminally ill patients and their relatives regarding dignity during end-of-life care in the emergency department. BACKGROUND: The respect given to the concept of dignity is significantly modifying the clinical relationship and the care framework involving the end-of-life patient in palliative care units, critical care units, hospices and their own homes. This situation is applicable to in-hospital emergency departments, where there is a lack of research which takes the experiences of end-of-life patients and their relatives into account...
February 8, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29417391/teaching-responsible-research-and-innovation-a-phronetic-perspective
#16
Niels Mejlgaard, Malene Vinther Christensen, Roger Strand, Ivan Buljan, Mar Carrió, Marta Cayetano I Giralt, Erich Griessler, Alexander Lang, Ana Marušić, Gema Revuelta, Gemma Rodríguez, Núria Saladié, Milena Wuketich
Across the European research area and beyond, efforts are being mobilized to align research and innovation processes and products with societal values and needs, and to create mechanisms for inclusive priority setting and knowledge production. A central concern is how to foster a culture of "Responsible Research and Innovation" (RRI) among scientists and engineers. This paper focuses on RRI teaching at higher education institutions. On the basis of interviews and reviews of academic and policy documents, it highlights the generic aspects of teaching aimed at invoking a sense of care and societal obligation, and provides a set of exemplary cases of RRI-related teaching...
February 7, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29414163/two-stage-processing-of-miscanthus-giganteus-using-anhydrous-ammonia-and-hot-water-for-effective-xylan-recovery-and-improved-enzymatic-saccharification
#17
Roent Dune A Cayetano, Tae Hyun Kim
A two-stage method using gaseous ammonia and hot water was proposed to recover xylan and lignin from Miscanthus. In this method, Miscanthus was treated with gaseous ammonia at elevated temperatures (60-150 °C) for various reaction times (1-48 h) in the first stage, termed as LMAA (low-moisture anhydrous ammonia) treatment. In the following stage, the LMAA-treated solid was subjected to hot-water treatment in a flow-through column reactor under various reaction conditions (170-220 °C, 30-90 min). After two-stage processing, the remaining solid contained mostly glucan (∼80% cellulose), which became highly digestible by enzymes...
May 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29364420/-multiresistance-and-factors-associated-with-the-presence-of-extended-spectrum-beta-lactamases-in-escherichia-coli-strains-isolated-from-urine-culture
#18
Milagros N Yábar, Berenice Curi-Pesantes, Carolina A Torres, Renzo Calderón-Anyosa, Maribel Riveros, Theresa J Ochoa
The empirical treatment of urinary infections is complicated by the presence of multiresistance and resistance to extendedspectrum beta-lactamases (ESBLs). The objective of this study was to describe the patterns of antibiotic resistance of Escherichia coli strains isolated from urine cultures and the clinical-epidemiological factors associated with the presence of ESBLs in a pediatric and an adult group. A total of 353 strains were collected from the Emergency and Hospitalization Sector of the Cayetano Heredia Hospital over 14 months, and 45...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29364407/-colonization-by-enterococcal-strains-resistant-to-vancomycin-in-patients-from-a-hospital-in-lima-peru
#19
Alisson Estrada-Román, Rafael Mendo-López, Lizeth Astocondor, Marcus Zervos, Coralith García
This cross-sectional study was conducted from November to December of 2013 at the Cayetano Heredia National Hospital in Lima, Peru, to determine the rate of infection with vancomycin-resistant enterococcus (VRE), the resistance genotype, and associated factors. The rate of infection with VRE was 6.2% (95% confidence interval [CI]: 1.67-10.73) and the resistance genotype isolated from all strains was the vanA gene. The factors associated with colonization with VRE were previous hospitalizations (p = 0.001) and the use of third-generation cephalosporins (p = 0...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29333839/-pallister-killian-syndrome-in-a-mexican-mestizo-patient-case-report
#20
Paola Mendelsberg-Fishbein, Constanza García-Delgado, Linda B Muñoz-Martínez, Maura Robledo-Cayetano, Leonardo J Mejía-Marín, Luis E Martínez-Barrera, Mabel Cerrillo-Hinojosa, Verónica F Moran-Barroso
Pallister-Killian syndrome is caused by a tetrasomy 12p mosaicism and is characterized by facial dysmorphism, pigmentary skin anomalies, congenital heart defects, diaphragmatic hernia, epilepsy and mental retardation. The diagnosis is complex as the cytogenetic analysis in blood is usually normal, requiring karyotyping in other tissues, therefore the clinical suspicion is critical to guide the diagnostic tests and the patient requires an interdisciplinary clinical evaluation regarding the several manifestation of the syndrome...
February 1, 2018: Archivos Argentinos de Pediatría
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