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https://www.readbyqxmd.com/read/29467187/-drosophila-larval-brain-neoplasms-present-tumour-type-dependent-genome-instability
#1
Fabrizio Rossi, Camille Stephan-Otto Attolini, Jose Luis Mosquera, Cayetano Gonzalez
Single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) are found at different rates in human cancer. To determine if these genetic lesions appear in Drosophila tumours we have sequenced the genomes of 17 malignant neoplasms caused by mutations in l(3)mbt, brat, aurA , or lgl We have found CNVs and SNPs in all the tumours. Tumour-linked CNVs range between 11 and 80 per sample, affecting between 92 and 1546 coding sequences. CNVs are in average less frequent in l(3)mbt than in brat lines. Nearly half of the CNVs fall within the 10 to 100Kb range, all tumour samples contain CNVs larger that 100 Kb and some have CNVs larger than 1Mb...
February 21, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29459803/-prevalence-and-severity-of-the-hepatopulmonar-syndrome-in-patients-with-liver-cirrhosis-attended-at-cayetano-heredia-hospital-between-january-and-december-2015
#2
Vanessa Valenzuela Granados, Soledad Violeta Calle Lunarejo, Jhosmell Walter Bautista Tiburcio, Héctor Daniel Villa Alvarado, Aida Del Carmen Rotta Rotta D, Karla Tafur Bances, José Luis Pinto Valdivia, Jorge Huerta-Mercado Tenorio, José Rojas Vilca
INTRODUCTION: The hepatopulmonary syndrome (HPS) is a rare complication of liver cirrhosis (LC) which significantly diminishes the quality of life for people who suffer. OBJECTIVES: To determine the prevalence and severity of HPS in patients with CH treated at the Cayetano Heredia (HCH) Hospital in the period from January to December 2015. MATERIALS AND METHODS: Cross-sectional study with sample size needed to determine the point prevalence calculated in 297 patients...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29452968/analysis-and-description-of-disease-specific-quality-of-life-in-patients-with-anal-fistula
#3
Manuel Ferrer-Márquez, Natalia Espínola-Cortés, Ángel Reina-Duarte, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla
INTRODUCTION: In patients diagnosed with anal fistula, knowing the quality of life specifically related to the disease can help coloproctology specialists to choose the most appropriate therapeutic strategy for each case. The aim of our study is to analyzse and describe the factors related to the specific quality of life in a consecutive series of patients diagnosed with anal fistula. METHODS: Observational, cross-sectional study carried out from March 2015 to February 2017...
February 13, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29435315/fluid-resuscitation-with-lactated-ringer-s-solution-vs-normal-saline-in-acute-pancreatitis-a-triple-blind-randomized-controlled-trial
#4
Enrique de-Madaria, Iván Herrera-Marante, Verónica González-Camacho, Laia Bonjoch, Noé Quesada-Vázquez, Isabel Almenta-Saavedra, Cayetano Miralles-Maciá, Nelly G Acevedo-Piedra, Manuela Roger-Ibáñez, Claudia Sánchez-Marin, Rosa Osuna-Ligero, Ángel Gracia, Pere Llorens, Pedro Zapater, Vikesh K Singh, Rocío Moreu-Martín, Daniel Closa
Background: Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective: The objective of this article was to compare the effect of lactated Ringer's solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods: We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29426198/modelling-the-effects-of-climate-and-land-use-change-on-the-hydrochemistry-and-ecology-of-the-river-wye-wales
#5
Gianbattista Bussi, Paul G Whitehead, Cayetano Gutiérrez-Cánovas, José L J Ledesma, Steve J Ormerod, Raoul-Marie Couture
Interactions between climate change and land use change might have substantial effects on aquatic ecosystems, but are still poorly understood. Using the Welsh River Wye as a case study, we linked models of water quality (Integrated Catchment - INCA) and climate (GFDL - Geophysical Fluid Dynamics Laboratory and IPSL - Institut Pierre Simon Laplace) under greenhouse gas scenarios (RCP4.5 and RCP8.5) to drive a bespoke ecosystem model that simulated the responses of aquatic organisms. The potential effects of economic and social development were also investigated using scenarios from the EU MARS project (Managing Aquatic Ecosystems and Water Resources under Multiple Stress)...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29421939/social-support-for-female-sexual-dysfunction-in-fibromyalgia
#6
José Granero-Molina, Tamara María Matarín Jiménez, Carmen Ramos Rodríguez, José Manuel Hernández-Padilla, Adelaida María Castro-Sánchez, Cayetano Fernández-Sola
The aim of this study is to describe and understand experiences related to social support for women with fibromyalgia who suffer from sexual dysfunction. An interpretive qualitative research methodology based on Gadamer's philosophical hermeneutics was used. Data collection included a focus group and in-depth interviews with 13 women who averaged 44.8 years of age and 14.3 years since being diagnosed with fibromyalgia. Data were analyzed using Fleming's method and two themes were identified: "searching for understanding in socio-family support" and "lack of formal support regarding fibromyalgia patient's sexuality...
March 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29421848/characterization-conservation-and-loss-of-dignity-at-the-end-of-life-in-the-emergency-department-a-qualitative-protocol
#7
Cayetano Fernández-Sola, José Granero-Molina, María Del Mar Díaz-Cortés, Francisca Rosa Jiménez-López, Pablo Roman-López, Encarnación Saez-Molina, Cayetano José Aranda-Torres, José María Muñoz-Terrón, María Paz García-Caro, José Manuel Hernández-Padilla
AIMS: to explore and understand the experiences of terminally-ill patients and their relatives regarding dignity during end-of-life care in the emergency department. BACKGROUND: the respect given to the concept of dignity is significantly modifying the clinical relationship and the care framework involving the end-of-life patient in palliative care units, critical care units, hospices and their own homes. This situation is applicable to in-hospital emergency departments, where there is a lack of research which takes the experiences of end-of-life patients and their relatives into account...
February 8, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29417391/teaching-responsible-research-and-innovation-a-phronetic-perspective
#8
Niels Mejlgaard, Malene Vinther Christensen, Roger Strand, Ivan Buljan, Mar Carrió, Marta Cayetano I Giralt, Erich Griessler, Alexander Lang, Ana Marušić, Gema Revuelta, Gemma Rodríguez, Núria Saladié, Milena Wuketich
Across the European research area and beyond, efforts are being mobilized to align research and innovation processes and products with societal values and needs, and to create mechanisms for inclusive priority setting and knowledge production. A central concern is how to foster a culture of "Responsible Research and Innovation" (RRI) among scientists and engineers. This paper focuses on RRI teaching at higher education institutions. On the basis of interviews and reviews of academic and policy documents, it highlights the generic aspects of teaching aimed at invoking a sense of care and societal obligation, and provides a set of exemplary cases of RRI-related teaching...
February 7, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29414163/two-stage-processing-of-miscanthus-giganteus-using-anhydrous-ammonia-and-hot-water-for-effective-xylan-recovery-and-improved-enzymatic-saccharification
#9
Roent Dune A Cayetano, Tae Hyun Kim
A two-stage method using gaseous ammonia and hot water was proposed to recover xylan and lignin from Miscanthus. In this method, Miscanthus was treated with gaseous ammonia at elevated temperatures (60-150 °C) for various reaction times (1-48 h) in the first stage, termed as LMAA (low-moisture anhydrous ammonia) treatment. In the following stage, the LMAA-treated solid was subjected to hot-water treatment in a flow-through column reactor under various reaction conditions (170-220 °C, 30-90 min). After two-stage processing, the remaining solid contained mostly glucan (∼80% cellulose), which became highly digestible by enzymes...
January 31, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29364420/-multiresistance-and-factors-associated-with-the-presence-of-extended-spectrum-beta-lactamases-in-escherichia-coli-strains-isolated-from-urine-culture
#10
Milagros N Yábar, Berenice Curi-Pesantes, Carolina A Torres, Renzo Calderón-Anyosa, Maribel Riveros, Theresa J Ochoa
The empirical treatment of urinary infections is complicated by the presence of multiresistance and resistance to extendedspectrum beta-lactamases (ESBLs). The objective of this study was to describe the patterns of antibiotic resistance of Escherichia coli strains isolated from urine cultures and the clinical-epidemiological factors associated with the presence of ESBLs in a pediatric and an adult group. A total of 353 strains were collected from the Emergency and Hospitalization Sector of the Cayetano Heredia Hospital over 14 months, and 45...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29364407/-colonization-by-enterococcal-strains-resistant-to-vancomycin-in-patients-from-a-hospital-in-lima-peru
#11
Alisson Estrada-Román, Rafael Mendo-López, Lizeth Astocondor, Marcus Zervos, Coralith García
This cross-sectional study was conducted from November to December of 2013 at the Cayetano Heredia National Hospital in Lima, Peru, to determine the rate of infection with vancomycin-resistant enterococcus (VRE), the resistance genotype, and associated factors. The rate of infection with VRE was 6.2% (95% confidence interval [CI]: 1.67-10.73) and the resistance genotype isolated from all strains was the vanA gene. The factors associated with colonization with VRE were previous hospitalizations (p = 0.001) and the use of third-generation cephalosporins (p = 0...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29333839/-pa%C3%A3-ister-kiuian-syndrome-in-a-mexican-mestizo-patient-case-report
#12
Paola Mendelsberg-Fishbein, Constanza García-Delgado, Linda B Muñoz-Martínez, Maura Robledo-Cayetano, Leonardo J Mejía-Marín, Luis E Martínez-Barrera, Mabel Cerrillo-Hinojosa, Verónica F Moran-Barroso
Pallister-Killian syndrome is caused by a tetrasomy 12p mosaicism and is characterized by facial dysmorphism, pigmentary skin anomalies, congenital heart defects, diaphragmatic hernia, epilepsy and mental retardation. The diagnosis is complex as the cytogenetic analysis in blood is usually normal, requiring karyotyping in other tissues, therefore the clinical suspicion is critical to guide the diagnostic tests and the patient requires an interdisciplinary clinical evaluation regarding the several manifestation of the syndrome...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29304124/the-effect-of-dna-degradation-bias-in-passive-sampling-devices-on-metabarcoding-studies-of-arthropod-communities-and-their-associated-microbiota
#13
Henrik Krehenwinkel, Marisa Fong, Susan Kennedy, Edward Greg Huang, Suzuki Noriyuki, Luis Cayetano, Rosemary Gillespie
PCR amplification bias is a well-known problem in metagenomic analysis of arthropod communities. In contrast, variation of DNA degradation rates is a largely neglected source of bias. Differential degradation of DNA molecules could cause underrepresentation of taxa in a community sequencing sample. Arthropods are often collected by passive sampling devices, like malaise traps. Specimens in such a trap are exposed to varying periods of suboptimal storage and possibly different rates of DNA degradation. Degradation bias could thus be a significant issue, skewing diversity estimates...
2018: PloS One
https://www.readbyqxmd.com/read/29286175/hyperbaric-oxygen-therapy-an-alternative-treatment-for-radiation-induced-cutaneous-ulcers
#14
Inés Fernández Canedo, Laura Padilla España, José Francisco Millán Cayetano, Juan Bosco Repiso Jiménez, Manuel Pérez Delgado, Magdalena de Troya Martín
Radiotherapy is a widely recognised treatment for non-melanoma skin cancer. We report three cases of radiation-induced skin ulcers in which hyperbaric oxygen therapy was administered in 90-min sessions, 5 days a week at 2.4 absolute atmospheres in a multiplace hyperbaric chamber. Hyperbaric oxygen therapy is an outpatient treatment that does not displace other classical treatments and may be used as an adjunct therapy.
December 29, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29220103/survival-study-of-treatment-adherence-by-patients-given-oral-oxibutynin-for-hyperhidrosis
#15
José Francisco Millán-Cayetano, Javier Del Boz, Pablo García-Montero, Cristina García-Harana, Francisco Rivas Ruiz, Magdalena de Troya-Martín
INTRODUCTION: In recent years, increasing use has been made of oral anticholinergics such as oxybutynin for the management of hyperhidrosis. The primary aim of this study is to determine the variables associated with adherence to this treatment, and secondarily to obtain data on its effectiveness, safety and adverse effects. MATERIAL AND METHODS: Prospective study of patients with hyperhidrosis, at any location, receiving treatment with oral oxybutynin in the period 2007-2016...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29191725/bonding-in-neonatal-intensive-care-units-experiences-of-extremely-preterm-infants-mothers
#16
Isabel María Fernández Medina, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla, Marcos Camacho Ávila, María Del Mar López Rodríguez
BACKGROUND: The birth of an extremely preterm infant can disrupt normal mother-infant physical contact and the care provided by the mother. This situation has an impact on the process of bonding between the mother and the child. AIM: The objective of this study was to describe and understand the experiences of mothers who have extremely preterm infants admitted in Neonatal Intensive Care Units with regard to their bonding process. METHODS: An interpretive, qualitative research methodology using Gadamer's philosophical hermeneutics was carried out...
November 27, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29119685/fundamental-care-and-knowledge-interests-implications-for-nursing-science
#17
José Granero-Molina, Cayetano Fernández-Sola, Ester Mateo Aguilar, Cayetano Aranda Torres, Pablo Román López, José Manuel Hernández-Padilla
AIMS AND OBJECTIVES: The aim of this discursive paper was to characterize the intra-theoretical interests of knowledge in nursing science as an epistemological framework for fundamental care. BACKGROUND: For Jürgen Habermas, theory does not separate knowledge interests from life. All knowledge, understanding and human research is always interested. Habermas formulated the knowledge interests in empirical-analytical, historical-hermeneutic and critical social sciences; but said nothing about health sciences and nursing science...
November 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29050704/patterns-of-food-avoidance-and-eating-behavior-in-women-with-fibromyalgia
#18
María Mar López-Rodríguez, José Granero Molina, Isabel María Fernández Medina, Cayetano Fernández Sola, Alicia Ruiz Muelle
INTRODUCTION: Fibromyalgia is a form of non-articular rheumatic disorder of unknown origin. It is characterized by widespread, chronic musculoskeletal pain. Patients with fibromyalgia suffer more frequently eating disorders, obesity, metabolic syndrome, and other gastrointestinal symptoms. Studies have pointed out to nutrition as a relevant factor in these patients. Some of them think that diet has an influence on fibromyalgia symptoms, and tend to adopt certain dietary patterns. This, combined with access to non-scientific information about diets and supplements, makes analysis of dietary behavior, avoidance, and restrictions particularly important...
November 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28958844/private-rheumatology-in-catalonia-spain
#19
Cayetano Alegre
OBJECTIVE: To establish the percentage of Catalonian rheumatologists who attended to private patients, to understand the most common processes in private practice, to determine the dedication to patient care and the necessary activities to guarantee proper care, such as continuing education and office management, and to know what techniques were most widely used. MATERIAL AND METHODS: A personalized survey of Catalonian rheumatologists whose e-mail addresses were made available to us...
September 25, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28917477/using-a-slit-knife-to-facilitate-mohs-micrographic-surgery-in-irregularly-shaped-areas
#20
José Francisco Millán-Cayetano, Inés Fernández-Canedo, Alberto Ortega-Sánchez, Magdalena de Troya-Martín
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
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