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https://www.readbyqxmd.com/read/28551913/-dynamic-changes-of-d-dimer-following-stroke
#1
Lihi Shapir, Bella Gross
AIMS: To find the correlation between plasma D-dimer levels after stroke with different etiologies, severity of the stroke and to uncover whether plasma D-dimer levels may be used as a prognostic factor of stroke complication. BACKGROUND: D-dimer is a product of fibrin degradation and it is elevated in systemic vascular events. The association between plasma D-dimer levels and stroke remain uncertain. METHODS: A total of 96 acute stroke patients were enrolled in this study...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551815/the-efficacy-of-surgical-treatment-of-recurrent-or-persistent-cervical-cancer-that-develops-in-a-previously-irradiated-field-a-monoinstitutional-experience
#2
Seiji Mabuchi, Yuri Matsumoto, Naoko Komura, Masaaki Sawada, Mie Tanaka, Eriko Yokoi, Katsumi Kozasa, Akihiko Yoshimura, Hiromasa Kuroda, Tadashi Kimura
BACKGROUND: There are no guidelines about the selection of recurrent cervical cancer patients for salvage surgery. METHODS: Patients who developed recurrent or persistent cervical cancer in a previously irradiated field and were subsequently treated with salvage surgery (the surgery group) or palliative care alone (the palliative group) were identified. Patient characteristics, treatment-related complications, and survival were retrospectively compared between the two groups...
May 27, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28551766/axl-gas6-expression-can-predict-for-adverse-prognosis-in-non-small-cell-lung-cancer-with-brain-metastases
#3
Xiaoliang Wu, Wenjuan Ma, Qianghua Zhou, Haijuan Yan, Zuan-Fu Lim, Mayan Huang, Chuangzhong Deng, Xingsu Yu, Huifang Su, Satoshi Komo, Haixia Yang, Xinke Zhang, Sijin Wen, Zhenfeng Zhang, Patrick C Ma
PURPOSE: Patients with non-small cell lung cancer (NSCLC) brain metastases (BM) have poor clinical outcomes. We sought to determine if AXL-GAS6 expression can be used as independent prognostic biomarkers for NSCLC BM. METHODS: We retrospectively studied the medical records of 98 patients diagnosed with advanced metastatic NSCLC from December 2000 to June 2014. Out of a total of 98 patients with NSCLC metastases, 66 patients were identified to have brain metastases...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28551689/perinatal-mortality-and-morbidity-of-growth-restricted-fetuses-and-newborns-own-experience-first-report
#4
Katarzyna Pankiewicz, Tomasz Maciejewski
AIM: to evaluate the outcome of pregnancies complicated by fetal growth restriction with particular emphasis on the factors (fetal and maternal) related to perinatal mortality and morbidity of the fetus and newborn. MATERIAL AND METHODS: Retrospective analysis of the documentation of 53 women admitted with the diagnosis of fetal growth restriction based on ultrasound examination (fetal biometry and fetal vessel Doppler abnormalities). 38 (71.7%) patients were referred to our department with the diagnosis of fetal growth restriction, whereas 15 (28...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28551673/tissue-factor-expression-does-not-predict-mortality-in-breast-cancer-patients
#5
Simon F Stämpfli, Alexander Akhmedov, Silke Hausladen, Zsuzsanna Varga, Konstantin J Dedes, Jens Hellermann, Thomas F Lüscher, Glen Kristiansen, Felix C Tanner, Alexander Breitenstein
BACKGROUND: Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear. MATERIALS AND METHODS: Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551669/effects-of-preoperative-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-on-survival-in-patients-with-extrahepatic-cholangiocarcinoma
#6
Yuki Kitano, Yo-Ichi Yamashita, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Tatsunori Miyata, Shigeki Nakagawa, Kosuke Mima, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba
BACKGROUND/AIM: As indicators of systemic inflammatory response, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) predict prognoses for various cancers. This study investigated their prognostic significance in extrahepatic cholangiocarcinoma (ECC). PATIENTS AND METHODS: We analyzed 120 patients who underwent surgery for ECC between 2000 and 2014. We calculated preoperative NLR and PLR and evaluated their correlations with patients' clinicopathological features and prognosis...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551667/duration-of-preoperative-biliary-drainage-as-a-prognostic-factor-after-pancreaticoduodenectomy-for-pancreatic-head-cancer
#7
Michinori Matsumoto, Yukio Nakabayashi, Yuki Fujiwara, Naotake Funamizu, Rota Noaki, Seiichiro Eto, Hiroshi Sugano, Masahiko Otsuka, Katsuhiko Yanaga
BACKGROUND/AIM: Preoperative biliary drainage (PBD) is often performed for jaundiced patients. However, the optimal duration of PBD remains unknown. The aim of this study was to investigate whether duration of PBD influenced the prognosis of patients after pancreaticoduodenectomy (PD) for pancreatic head cancer. PATIENTS AND METHODS: Twenty-five patients who underwent PD for pancreatic head cancer with obstructive jaundice between 2007 and 2013 were included. Tumor and host factors were analyzed to evaluate their potential prognostic effects and patients' characteristics between the two groups according to the duration of PBD were analyzed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551666/clinical-features-and-outcome-of-surgical-patients-with-non-b-non-c-hepatocellular-carcinoma
#8
Shigeki Wakiyama, Michinori Matsumoto, Koichiro Haruki, Takeshi Gocho, Taro Sakamoto, Hiroaki Shiba, Yasuro Futagawa, Yuichi Ishida, Katsuhiko Yanaga
AIM: To investigate the clinical characteristics and prognosis of surgical patients with non-B non-C hepatocellular carcinoma (NBNC-HCC) compared to those of hepatitis B virus (HBV)- and hepatitis C virus (HCV)-HCC. PATIENTS AND METHODS: Clinical data and outcomes were compared among the three groups. Prognostic factors of patients with NBNC-HCC were investigated. RESULTS: Compared to HBV-HCC, patients with NBNC-HCC had higher chance of hypertension (HTN) (p<0...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551661/prognostic-significance-of-preoperative-anemia-in-patients-undergoing-surgery-for-renal-cell-carcinoma-a-meta-analysis
#9
Leilei Xia, Guodong Hu, Thomas J Guzzo
AIM: To better evaluate the association between preoperative anemia and outcomes in patients following radical or partial nephrectomy for renal cell carcinoma (RCC). MATERIALS AND METHODS: A meta-analysis of hazard ratios (HR) was conducted to measure the association between preoperative anemia and all-cause mortality (ACM), cancer-specific mortality (CSM), and disease recurrence (DR) in patients who underwent surgery for RCC. RESULTS: A total of 14 studies (8,673 patients) met the eligibility criteria...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551655/analysis-of-factors-for-predicting-survival-in-soft-tissue-sarcoma-with-metastatic-disease-at-initial-presentation
#10
Tomoki Nakamura, Hirohisa Katagiri, Yoji Shido, Shunsuke Hamada, Kenji Yamada, Akihito Nagano, Satoshi Yamada, Satoshi Tsukushi, Daisuke Ishimura, Akihiko Matsumine, Akihiro Sudo, Yoshihiro Nishida
BACKGROUND/AIM: We aimed to confirm predictors of survival in soft-tissue sarcoma (STS) patients with metastatic disease at initial presentation in 9 Institutions under the Tokai Musculoskeletal Oncology Consortium. PATIENTS AND METHODS: Between 2008 and 2013, 47 STS patients with metastatic disease at initial presentation were referred for treatment. The mean follow-up duration was 24 months. RESULTS: The mean C-reactive protein (CRP) levels were 2...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551654/overexpression-of-egfr-as-an-independent-prognostic-factor-in-adenocarcinoma-of-the-esophagogastric-junction
#11
Kenichi Aratani, Shuhei Komatsu, Daisuke Ichikawa, Takuma Ohashi, Mahito Miyamae, Wataru Okajima, Taisuke Imamura, Jun Kiuchi, Keiji Nishibeppu, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto, Hitoshi Tsuda, Eigo Otsuji
BACKGROUND: Adenocarcinoma of the esophagogastric junction (AEG) has increased in Western and Eastern countries, and its prognosis remains poor. We tested whether epidermal growth factor receptor (EGFR), that is overexpressed in various tumors, acts as a cancer-promoting gene through overexpression in AEG. MATERIALS AND METHODS: We analyzed 104 primary AEG tumors which were curatively resected in our hospital between 2000 and 2010. RESULTS: Overexpression of EGFR protein was detected in 47% primary AEG tumor samples, and significantly associated with venous and lymphatic invasion, tumor depth and lymph node metastasis...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551653/clinical-relevance-of-serum-her2-and-circulating-tumor-cell-detection-in-metastatic-breast-cancer-patients
#12
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter Andreas Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
BACKGROUND/AIM: Presence of circulating tumor cells (CTCs) is associated with impaired survival in metastatic breast cancer (MBC). This study was designed to evaluate whether assessment of serum HER2 (sHER2) levels provide additional prognostic information in MBC. MATERIALS AND METHODS: Two hundred and fifty-three MBC patients were enrolled in this multicentre trial. CTCs were detected before the start of first- or later-line treatment using the CellSearch system...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551643/clinical-outcomes-and-prognostic-factors-of-adenoid-cystic-carcinoma-of-the-head-and-neck
#13
Samuel Jang, Priyesh N Patel, Randall J Kimple, Timothy M McCulloch
BACKGROUND: Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with unpredictable growth and poorly understood prognostic factors. PATIENTS AND METHODS: A database search of patients treated at a single Institution was used to identify patients with histologically-confirmed ACC. Patient, tumor, and treatment characteristics were examined via review of medical records. RESULTS: Overall survival of 70 patients identified at 5, 10, and 15 years was 80...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551632/the-prognostic-value-of-the-immunohistochemical-expression-of-phosphorylated-rb-and-p16-proteins-in-association-with-cyclin-d1-and-the-p53-pathway-in-a-large-cohort-of-patients-with-breast-cancer-treated-with-taxane-based-adjuvant-chemotherapy
#14
Theofani Gavressea, Konstantine T Kalogeras, Georgia-Angeliki Koliou, Flora Zagouri, Georgios Lazaridis, Helen Gogas, Kostas Tsigaridas, Angelos Koutras, Kalliopi Petraki, Christos Markopoulos, Elissavet Pazarli, Gerasimos Aravantinos, Christos Papadimitriou, Pavlos Papakostas, Nektarios Koufopoulos, Charisios Karanikiotis, Sofia Chrisafi, Haralambos P Kalofonos, Dimitrios Pectasides, George Fountzilas, Kitty Pavlakis
BACKGROUND: The retinoblastoma (RB) gene is a tumor-suppressor gene that plays a central role in regulating the cell cycle. Inactivation of this gene is involved in breast cancer. PATIENTS AND METHODS: A total of 827 patients with breast cancer treated with taxane-based adjuvant chemotherapy were included in the study. Protein expression of RB, phosphorylated RB (pRB), p16, cyclin D1 and p53 was evaluated by immunohistochemistry. RESULTS: Neither of the retinoblastoma markers (RB and pRB) reached statistical significance in terms of their association with disease-free or overall survival...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551630/expression-and-prognostic-significance-of-ep300-tp53-and-bax-in-clear-cell-renal-cell-carcinoma
#15
Janusz Godlewski, Bartlomiej E Krazinski, Anna E Kowalczyk, Jolanta Kiewisz, Jacek Kiezun, Przemyslaw Kwiatkowski, Agnieszka Sliwińska-Jewsiewicka, Piotr W Wierzbicki, Zbigniew Kmieć
BACKGROUND: Histone acetyltransferase E1A-binding protein p300 (EP300), tumor protein p53 (TP53) and B-cell lymphoma-2-associated X protein (BAX) contribute to the regulation of the cell cycle and apoptosis, cellular processes that are often impaired in cancer cells. The aim of this study was to determine the expression levels of EP300, TP53 and BAX genes and their respective proteins in clear cell renal cell carcinoma (ccRCC) and evaluate the value of these factors as prognostic factors...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551624/immunoregulatory-function-of-lymphatic-endothelial-cells-in-tumor-draining-lymph-nodes-of-human-gastric-cancer
#16
Mao Tokumoto, Hiroaki Tanaka, Yukie Tauchi, Tatsuro Tamura, Takahiro Toyokawa, Kenjiro Kimura, Kazuya Muguruma, Masakazu Yashiro, Kiyoshi Maeda, Kosei Hirakawa, Masaichi Ohira
BACKGROUND/AIM: Lymph node metastasis is the most important prognostic factor for patients with gastric cancer. Increasing evidence suggests that lymphatic endothelial cells (LECs) regulate immune responses. The aim of this study was to examine the effect of LECs on the activation of CD4(+) T cells. MATERIALS AND METHODS: We examined the impact of cancer cells on the phenotype and production of cytokines of LECs derived from tumor-draining lymph nodes. RESULTS: We showed that LECs inhibited CD4(+) T cell production of cytokines, such as IL-2, IL-10, and INF-γ...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551388/anaplastic-lymphoma-kinase-protein-positive-diffuse-large-b-cell-lymphoma-a-developing-world-experience
#17
Huzaifah Salat, Nasir Ud Din, Tariq Moatter, Naila Kayani, Arsalan Ahmed
Anaplastic lymphoma kinase (ALK) positive diffuse large B-cell lymphoma (ALK+DLBCL) is a rare, distinct and aggressive subtype of non-Hodgkin's lymphoma (NHL). These tumors are considered to be derived from post-germinal center B cells but peculiarly their distinction is based on the fact that they are ALK-positive neoplastic B cells but lack expression of B cell markers (CD19,CD20, CD79a), T cell markers (CD3, CD5) and CD30. Its broad differential diagnosis and similarities to plasmablastic lymphoma, immunoblastic DLBCL, Anaplastic large-cell lymphoma (ALCL) of T-null cell lineage, and poorly differentiated/anaplastic carcinoma pose a grave challenge to physicians with conventional costly treatment for DLBCL failing to yield any clinical or prognostic significance in ALK+DLBCL...
March 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28551384/cpeb4-immunohistochemical-expression-is-associated-to-prognosis-in-stage-iv-colorectal-carcinoma
#18
D Cortés-Guiral, C Pastor-Iodate, C Díaz Del Arco, L Del Puerto-Nevado, M J Fernández-Aceñero
The cytoplasmic polyadenylation element binding protein 4 (CPEB4) is a RNA binding protein and translational regulator. It has been associated with tumor growth, vascularization and invasion and with tumor progression in breast, pancreas and lung carcinomas. To the best of our knowledge only one previous report has analyzed the prognostic value of CPEB4 in an experimental model of colorectal carcinoma. We have reviewed the files of patients with stage IV colorectal carcinoma metastatic to the liver. All the patients had received chemotherapy followed by hepatic metastasis resection and subsequent resection of the colon (liver-first approach)...
May 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28551378/radical-operation-for-hilar-cholangiocarcinoma-in-comparable-eastern-and-western-centers-outcome-analysis-and-prognostic-factors
#19
Norihisa Kimura, Alastair L Young, Yoshikazu Toyoki, Judith I Wyatt, Giles J Toogood, Ernest Hidalgo, K Rajendra Prasad, Daisuke Kudo, Keinosuke Ishido, Kenichi Hakamada, J Peter A Lodge
BACKGROUND: Extensive resection for hilar cholangiocarcinoma is the most effective treatment, but high morbidity and poor prognosis remain concerns. Previous data have shown marked differences in outcomes between comparable Eastern and Western centers. We compared the outcomes of the management for hilar cholangiocarcinoma at one Japanese and one British institution with comparable experience. METHODS: Of 298 consecutive patients with hilar cholangiocarcinoma evaluated at Hirosaki University Hospital, Japan and St...
May 24, 2017: Surgery
https://www.readbyqxmd.com/read/28551338/evaluation-of-the-bone-margin-in-oral-squamous-cell-carcinoma
#20
REVIEW
Joshua E Lubek, Kelly R Magliocca
Squamous cell carcinoma is the most common cancer within the oral cavity. Bone invasion involving the maxilla or mandible is reported in up to 50% of tumors on initial presentation. Although conflicting data exist, true bone invasion is thought to negatively affect risk of recurrence and long-term prognosis. The ultimate goal is to identify accurately bone invasion preoperatively and intraoperatively, because it affects the treatment plan. This article focuses on methods of evaluation of the bone margin in the preoperative and intraoperative setting, discussing the implications for prognostic, staging, and reconstructive methods...
May 24, 2017: Oral and Maxillofacial Surgery Clinics of North America
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