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https://www.readbyqxmd.com/read/28646862/a-clinical-utility-assessment-of-the-automatic-measurement-method-of-the-quality-of-meibomian-glands
#1
Robert Koprowski, Lei Tian, Paweł Olczyk
BACKGROUND: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, an automatic analysis method was developed to assess MGD quantiatively. MATERIALS: The analysis made use of 228 images of 57 patients recorded by OCULUS Keratograph(®) 5 M with a resolution of 1024 × 1360 pixels concern 30 eyes of healthy individuals (14 women and 16 men) and 27 eyes of sick patients (10 women and 17 men)...
June 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28567496/manifestation-of-meibomian-gland-dysfunction-in-patients-with-sj%C3%A3-gren-s-syndrome-non-sj%C3%A3-gren-s-dry-eye-and-non-dry-eye-controls
#2
Yeon Soo Kang, Hyo Seok Lee, Ying Li, Won Choi, Kyung Chul Yoon
PURPOSE: To evaluate the manifestation of meibomian gland dysfunction in patients with Sjögren's syndrome (SS), non-Sjögren's syndrome dry eye (non-SS) patients, and non-dry eye controls. METHODS: We recruited 31 participants with SS dry eye, 30 participants with non-SS dry eye, and 35 healthy controls without dry eye symptoms. Noninvasive tear breakup time (NITBUT) and meibomian gland dropout score (meiboscore) were measured using the Oculus Keratograph 5 M...
May 31, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28544605/assessment-of-meibomian-glands-and-tear-film-in-post-refractive-surgery-patients
#3
Ji Won Jung, Jung Yong Kim, Hee Seung Chin, Young Ju Suh, Tae-Im Kim, Kyoung Yul Seo
IMPORTANCE: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. BACKGROUND: To compare ocular surface parameters between post-refractive surgery patients and normal controls. DESIGN: Cross-sectional single center study PARTICIPANTS: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients...
May 22, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28497458/ocular-surface-disease-in-patients-under-topical-treatment-for-glaucoma
#4
Francisco Pérez-Bartolomé, Jose M Martínez-de-la-Casa, Pedro Arriola-Villalobos, Cristina Fernández-Pérez, Vicente Polo, Julián García-Feijoó
PURPOSE: To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy. METHODS: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC)...
May 10, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495356/scleral-topography-analysed-by-optical-coherence-tomography
#5
Stefan Bandlitz, Joachim Bäumer, Uwe Conrad, James Wolffsohn
PURPOSE: A detailed evaluation of the corneo-scleral-profile (CSP) is of particular relevance in soft and scleral lenses fitting. The aim of this study was to use optical coherence tomography (OCT) to analyse the profile of the limbal sclera and to evaluate the relationship between central corneal radii, corneal eccentricity and scleral radii. METHODS: Using OCT (Optos OCT/SLO; Dunfermline, Scotland, UK) the limbal scleral radii (SR) of 30 subjects (11M, 19F; mean age 23...
August 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28471879/investigating-the-short-term-effect-of-eyelid-massage-on-corneal-topography
#6
Britta H Riede-Pult, Katharine Evans, Heiko Pult
PURPOSE: The aim of this study was to evaluate the short-term effect of eyelid massage, after the use of warm compresses, on corneal topography. METHODS: Corneal topography was evaluated on 20 subjects (mean age, 47.0 [SD ±17.3] years) using the Oculus Keratograph (Oculus, Wetzlar, Germany). Corneal eccentricity (Epsilon) was compared between topography measurements before eyelid warming (using warm compresses) (T1), after eyelid warming (T2), directly after eyelid massage (T3), and 30 minutes after eyelid massage (T4)...
June 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28060066/assessment-of-the-tear-meniscus-by-strip-meniscometry-and-keratograph-in-patients-with-dry-eye-disease-according-to-the-presence-of-meibomian-gland-dysfunction
#7
COMPARATIVE STUDY
Kang Won Lee, Jung Yong Kim, Hee Seung Chin, Kyoung Yul Seo, Tae-Im Kim, Ji Won Jung
PURPOSE: We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects. METHODS: We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands...
February 2017: Cornea
https://www.readbyqxmd.com/read/28060064/automated-measurement-of-tear-film-dynamics-and-lipid-layer-thickness-for-assessment-of-non-sj%C3%A3-gren-dry-eye-syndrome-with-meibomian-gland-dysfunction
#8
Yong Woo Ji, Jeihoon Lee, Hun Lee, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
PURPOSE: To investigate automated values from an advanced corneal topographer with a built-in real keratometer, color camera, and ocular surface interferometer for the evaluation of non-Sjögren dry eye syndrome (NSDES) with meibomian gland dysfunction (MGD). METHODS: Sixty-four patients (64 eyes) diagnosed with NSDES with MGD were enrolled. All eyes were evaluated using the Ocular Surface Disease Index (OSDI), fluorescence staining score, tear film breakup time (TBUT), Schirmer test, and MGD grade...
February 2017: Cornea
https://www.readbyqxmd.com/read/28003972/changes-of-meibomian-glands-in-patients-with-type-2-diabetes-mellitus
#9
Tao Yu, Wei-Yun Shi, Ai-Ping Song, Yang Gao, Guang-Fu Dang, Gang Ding
AIM: To investigate the morphological changes of meibomian glands in patients with type 2 diabetes mellitus (DM). METHODS: Of 118 eyes (118 patients) with type 2 DM (DM group) and 100 eyes of 100 control subjects (control group) were enrolled. After completing an ocular surface disease index (OSDI) questionnaire, the non-invasive tear film break-up time (NI-BUT) and the structure of the meibomian glands (MGs, meibography) were assessed by the Keratograph 5M system...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941381/automated-measurement-of-tear-film-dynamics-and-lipid-layer-thickness-for-assessment-of-non-sj%C3%A3-gren-dry-eye-syndrome-with-meibomian-gland-dysfunction
#10
Yong Woo Ji, Jeihoon Lee, Hun Lee, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
PURPOSE: To investigate automated values from an advanced corneal topographer with a built-in real keratometer, color camera, and ocular surface interferometer for the evaluation of non-Sjögren dry eye syndrome (NSDES) with meibomian gland dysfunction (MGD). METHODS: Sixty-four patients (64 eyes) diagnosed with NSDES with MGD were enrolled. All eyes were evaluated using the Ocular Surface Disease Index (OSDI), fluorescence staining score, tear film breakup time (TBUT), Schirmer test, and MGD grade...
December 8, 2016: Cornea
https://www.readbyqxmd.com/read/27913889/ocular-pharmacology-of-tear-film-dry-eye-and-allergic-conjunctivitis
#11
Shilpa Gulati, Sandeep Jain
Dry Eye Disease (DED) is "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability with potential damage to the ocular surface." DED comprises two etiologic categories: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Diagnostic workup of DED should include clinical history, symptom questionnaire, fluorescein TBUT, ocular surface staining grading, Schirmer I/II, lid and meibomian pathology, meibomian expression, followed by other available tests...
2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27868417/-evaluation-of-tear-film-and-meibomian-gland-function-in-dry-eye-patients-using-keratograph-5m
#12
Kexuan Zhu, Wenjia Xie, Jinglu Ying, Yufeng Yao
Objective: To assess the application of Keratograph 5M in evaluating tear film and meibomian gland function in patients with dry eye. Methods: A total of 144 eyes were recruited in the study, in which 72 eyes were from patients diagnosed with dry eye and 72 eyes were from healthy subjects. All subjects finished following tests or examinations:ocular surface disease index (OSDI) to evaluate eye symptoms; Keratograph 5M examination to obtain tear meniscus height (TMH), noninvasive tear break-up time (NIBUT) including first NIBUT (NIBUT-Fir) and average NIBUT (NIBUT-Ave), and infrared meibography; and fluorescein sodium staining to obtain fluorescein tearbreak-up time (FBUT)...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27749453/assessment-of-the-tear-meniscus-by-strip-meniscometry-and-keratograph-in-patients-with-dry-eye-disease-according-to-the-presence-of-meibomian-gland-dysfunction
#13
Kang Won Lee, Jung Yong Kim, Hee Seung Chin, Kyoung Yul Seo, Tae-Im Kim, Ji Won Jung
PURPOSE: We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects. METHODS: We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands...
October 5, 2016: Cornea
https://www.readbyqxmd.com/read/27695283/agreement-of-noninvasive-tear-break-up-time-measurement-between-tomey-rt-7000-auto-refractor-keratometer-and-oculus-keratograph-5m
#14
Ryan Lee, Sharon Yeo, Han Tun Aung, Louis Tong
BACKGROUND: It is difficult to standardize assessment of dry eye in different clinical settings. Increasingly, tear stability is recognized to be important for the definition and assessment of patients with dry eye. Recently, two commercially available instruments have been made available for objectively measuring noninvasive tear break-up time (NIBUT), as an indicator of tear stability: the Tomey RT-7000 Auto Refractor-Keratometer and Oculus Keratograph (K)5M. We aim to assess the agreement of NIBUT measurements using these modalities...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27668635/assessment-of-lower-tear-meniscus
#15
Anji Wei, Qihua Le, Jiaxu Hong, Wentao Wang, Fei Wang, Jianjiang Xu
PURPOSE: To evaluate the applicability of the fourth-generation OCULUS keratograph in measuring lower tear meniscus height. METHODS: Seventy cases (140 eyes) with dry eye disease and 37 controls (74 eyes) were enrolled. Tear breakup time (TBUT), Schirmer test I, and corneal fluorescein staining were examined. The images of lower tear meniscus were obtained by OCULUS keratograph. The tear meniscus height was measured and its correlation with traditional tear film diagnostic tests were analyzed...
September 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27600511/topographic-determination-of-corneal-asphericity-as-a-function-of-age-gender-and-refractive-error
#16
Negareh Yazdani, Leila Shahkarami, Hadi OstadiMoghaddam, Asieh Ehsaei
The aim of the study is to evaluate corneal asphericity in three diameters of 5, 6, and 7 mm, and to assess the effect of age, refractive error, and gender on asphericity. The study included 500 healthy subjects with a mean ± SD age of 29.51 ± 11.53 years. All analyses were based on the right eyes of the patients. Topographic data were analyzed using Oculus Keratograph 4. Mean ± SD corneal asphericity values of the study population in 5, 6, and 7 mm diameters were -0.21 ± 0.11, -0.24 ± 0.10, and -0...
August 2017: International Ophthalmology
https://www.readbyqxmd.com/read/27286185/a-quantitative-method-for-assessing-the-quality-of-meibomian-glands
#17
Robert Koprowski, Sławomir Wilczyński, Paweł Olczyk, Anna Nowińska, Beata Węglarz, Edward Wylęgała
INTRODUCTION: Meibomian gland dysfunction is a common cause of dry eye syndrome which can also lead to eyelid inflammation. Today, diagnostics of meibomian glands is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, this article proposes a new automatic analysis method which provides a quantitative assessment of meibomian gland dysfunction. METHOD: The new algorithm involves a sequence of operations: image acquisition (acquisition of data from OCULUS Keratograph® 5M); image pre-processing (image conversion to gray levels, median filtering, removal of uneven lighting, normalization); main image processing (binarization, morphological opening, labeling, Gaussian filtering, skeletonization, distance transform, watersheds)...
August 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27190639/repeatability-and-reproducibility-of-noninvasive-keratograph-5m-measurements-in-patients-with-dry-eye-disease
#18
Lei Tian, Jing-Hao Qu, Xiao-Yu Zhang, Xu-Guang Sun
Purpose. To determine the intraexaminer repeatability and interexaminer reproducibility of tear meniscus height (TMH) and noninvasive Keratograph tear breakup time (NIKBUT) measurements obtained with the Keratograph 5M (K5M) in a sample of healthy and dry eye populations. Methods. Forty-two patients with dry eye disease (DED group) and 42 healthy subjects (healthy group) were recruited in this prospective study. In all subjects, each eye received 3 consecutive measurements using the K5M for the TMH and NIKBUTs (NIKBUT-first and NIKBUT-average)...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/26890702/assessing-ocular-bulbar-redness-a-comparison-of-methods
#19
Laura E Downie, Peter R Keller, Algis J Vingrys
PURPOSE: We consider whether quantification of ocular bulbar redness, using image processing of relative Red-channel activity (Red-value), can be applied to a clinical sample and how this approach compares to an automated bulbar redness grading technique (Oculus Keratograph 5M, R-scan). METHODS: Red-values from dry eye patients (n = 25) were determined using image processing of digital photographs over the nasal bulbar conjunctiva. Red-values were compared with subjective grades from six clinicians who graded the images using the IER scale...
March 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/26881059/evaluation-of-dry-eye-and-meibomian-gland-dysfunction-in-teenagers-with-myopia-through-noninvasive-keratograph
#20
Xiu Wang, Xiaoxiao Lu, Jun Yang, Ruihua Wei, Liyuan Yang, Shaozhen Zhao, Xilian Wang
Purpose. This study aims to evaluate dry eye and ocular surface conditions of myopic teenagers by using questionnaire and clinical examinations. Methods. A total of 496 eyes from 248 myopic teenagers (7-18 years old) were studied. We administered Ocular Surface Disease Index (OSDI) questionnaire, slit-lamp examination, and Keratograph 5M. The patients were divided into 2 groups based on OSDI dry eye standard, and their ocular surfaces and meibomian gland conditions were evaluated. Results. The tear meniscus heights of the dry eye and normal groups were in normal range...
2016: Journal of Ophthalmology
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