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Shilpa Gulati, Sandeep Jain
Dry Eye Disease (DED) is "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability with potential damage to the ocular surface." DED comprises two etiologic categories: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Diagnostic workup of DED should include clinical history, symptom questionnaire, fluorescein TBUT, ocular surface staining grading, Schirmer I/II, lid and meibomian pathology, meibomian expression, followed by other available tests...
December 3, 2016: Handbook of Experimental Pharmacology
Kexuan Zhu, Wenjia Xie, Jinglu Ying, Yufeng Yao
Objective: To assess the application of Keratograph 5M in evaluating tear film and meibomian gland function in patients with dry eye. Methods: A total of 144 eyes were recruited in the study, in which 72 eyes were from patients diagnosed with dry eye and 72 eyes were from healthy subjects. All subjects finished following tests or examinations:ocular surface disease index (OSDI) to evaluate eye symptoms; Keratograph 5M examination to obtain tear meniscus height (TMH), noninvasive tear break-up time (NIBUT) including first NIBUT (NIBUT-Fir) and average NIBUT (NIBUT-Ave), and infrared meibography; and fluorescein sodium staining to obtain fluorescein tearbreak-up time (FBUT)...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Kang Won Lee, Jung Yong Kim, Hee Seung Chin, Kyoung Yul Seo, Tae-Im Kim, Ji Won Jung
PURPOSE: We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects. METHODS: We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands...
October 5, 2016: Cornea
Ryan Lee, Sharon Yeo, Han Tun Aung, Louis Tong
BACKGROUND: It is difficult to standardize assessment of dry eye in different clinical settings. Increasingly, tear stability is recognized to be important for the definition and assessment of patients with dry eye. Recently, two commercially available instruments have been made available for objectively measuring noninvasive tear break-up time (NIBUT), as an indicator of tear stability: the Tomey RT-7000 Auto Refractor-Keratometer and Oculus Keratograph (K)5M. We aim to assess the agreement of NIBUT measurements using these modalities...
2016: Clinical Ophthalmology
Anji Wei, Qihua Le, Jiaxu Hong, Wentao Wang, Fei Wang, Jianjiang Xu
PURPOSE: To evaluate the applicability of the fourth-generation OCULUS keratograph in measuring lower tear meniscus height. METHODS: Seventy cases (140 eyes) with dry eye disease and 37 controls (74 eyes) were enrolled. Tear breakup time (TBUT), Schirmer test I, and corneal fluorescein staining were examined. The images of lower tear meniscus were obtained by OCULUS keratograph. The tear meniscus height was measured and its correlation with traditional tear film diagnostic tests were analyzed...
September 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Negareh Yazdani, Leila Shahkarami, Hadi OstadiMoghaddam, Asieh Ehsaei
The aim of the study is to evaluate corneal asphericity in three diameters of 5, 6, and 7 mm, and to assess the effect of age, refractive error, and gender on asphericity. The study included 500 healthy subjects with a mean ± SD age of 29.51 ± 11.53 years. All analyses were based on the right eyes of the patients. Topographic data were analyzed using Oculus Keratograph 4. Mean ± SD corneal asphericity values of the study population in 5, 6, and 7 mm diameters were -0.21 ± 0.11, -0.24 ± 0.10, and -0...
September 6, 2016: International Ophthalmology
Robert Koprowski, Sławomir Wilczyński, Paweł Olczyk, Anna Nowińska, Beata Węglarz, Edward Wylęgała
INTRODUCTION: Meibomian gland dysfunction is a common cause of dry eye syndrome which can also lead to eyelid inflammation. Today, diagnostics of meibomian glands is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, this article proposes a new automatic analysis method which provides a quantitative assessment of meibomian gland dysfunction. METHOD: The new algorithm involves a sequence of operations: image acquisition (acquisition of data from OCULUS Keratograph® 5M); image pre-processing (image conversion to gray levels, median filtering, removal of uneven lighting, normalization); main image processing (binarization, morphological opening, labeling, Gaussian filtering, skeletonization, distance transform, watersheds)...
August 1, 2016: Computers in Biology and Medicine
Lei Tian, Jing-Hao Qu, Xiao-Yu Zhang, Xu-Guang Sun
Purpose. To determine the intraexaminer repeatability and interexaminer reproducibility of tear meniscus height (TMH) and noninvasive Keratograph tear breakup time (NIKBUT) measurements obtained with the Keratograph 5M (K5M) in a sample of healthy and dry eye populations. Methods. Forty-two patients with dry eye disease (DED group) and 42 healthy subjects (healthy group) were recruited in this prospective study. In all subjects, each eye received 3 consecutive measurements using the K5M for the TMH and NIKBUTs (NIKBUT-first and NIKBUT-average)...
2016: Journal of Ophthalmology
Laura E Downie, Peter R Keller, Algis J Vingrys
PURPOSE: We consider whether quantification of ocular bulbar redness, using image processing of relative Red-channel activity (Red-value), can be applied to a clinical sample and how this approach compares to an automated bulbar redness grading technique (Oculus Keratograph 5M, R-scan). METHODS: Red-values from dry eye patients (n = 25) were determined using image processing of digital photographs over the nasal bulbar conjunctiva. Red-values were compared with subjective grades from six clinicians who graded the images using the IER scale...
March 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
Xiu Wang, Xiaoxiao Lu, Jun Yang, Ruihua Wei, Liyuan Yang, Shaozhen Zhao, Xilian Wang
Purpose. This study aims to evaluate dry eye and ocular surface conditions of myopic teenagers by using questionnaire and clinical examinations. Methods. A total of 496 eyes from 248 myopic teenagers (7-18 years old) were studied. We administered Ocular Surface Disease Index (OSDI) questionnaire, slit-lamp examination, and Keratograph 5M. The patients were divided into 2 groups based on OSDI dry eye standard, and their ocular surfaces and meibomian gland conditions were evaluated. Results. The tear meniscus heights of the dry eye and normal groups were in normal range...
2016: Journal of Ophthalmology
Yinhui Yu, Huixia Hua, Menghan Wu, Yibo Yu, Wangshu Yu, Kairan Lai, Ke Yao
PURPOSE: To compare dry-eye signs and symptoms after femtosecond laser-assisted cataract surgery and conventional phacoemulsification. SETTING: Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China. DESIGN: Prospective consecutive nonrandomized comparative cohort study. METHODS: Consecutive patients who had femtosecond laser-assisted or phacoemulsification cataract surgery were assessed...
December 2015: Journal of Cataract and Refractive Surgery
Sara Ortiz-Toquero, Guadalupe Rodriguez, Victoria de Juan, Raul Martin
PURPOSE: To determine the repeatability of the back optic zone radius (BOZR) of rigid gas permeable (GP) contact lens (CL) proposed by new software for fitting in healthy and keratoconus eyes and to compare with the diagnostic CL fitting method. METHODS: Three consecutive corneal topographies (Oculus-Keratograph) were performed and analyzed with APEX new software CL fitting (Hecht-Contactlinsen, Germany) in 40 healthy and 40 keratoconus eyes fitted with GP using conventional diagnostic method...
March 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Jiwon Baek, Sang Hee Doh, Sung Kun Chung
PURPOSE: To study the repeatability and reproducibility of tear meniscus height (TMH) measurements obtained with a keratograph and Fourier domain optical coherence tomography (FD-OCT) and to assess their agreement in patients with dry eye. METHODS: Sixty-four eyes with dry eye were analyzed by the Schirmer test, tear breakup time test, and fluorescein corneal staining. The TMH was measured 3 times using both devices by 2 different examiners. The repeatability and reproducibility of measurements were assessed by within-subject standard deviation (Sw), repeatability (2...
October 2015: Cornea
Nizar Saleh Abdelfattah, Anna Dastiridou, SriniVas R Sadda, Olivia L Lee
PURPOSE: To test the validity of ocular surface assessment tools offered by a corneal topographer (Oculus Keratograph 5M). METHODS: Over 9 months, 296 eyes were imaged and divided into 2 groups: ocular surface disease (OSD) group (223 eyes) with clinically diagnosed meibomian gland dysfunction or dry eye syndrome and control group (73 eyes). All eyes were imaged using the noninvasive Keratograph tear breakup time (NIKBUT), tear meniscus height (TMH), and meibography tools of the Oculus K5M...
October 2015: Cornea
Pam Satjawatcharaphong, Shaokui Ge, Meng C Lin
PURPOSE: To identify patient characteristics at a baseline ocular surface evaluation that correlate with improvement in dry eye symptoms at a follow-up visit after treatment with the LipiFlow Thermal Pulsation System. METHODS: Thirty-two patients completed a comprehensive baseline ocular surface evaluation and were treated with the LipiFlow Thermal Pulsation System followed by maintenance home therapy. Lipid layer thickness and blink pattern were determined using the LipiView Interferometer...
September 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Stephanie M Cox, Kelly K Nichols, Jason J Nichols
PURPOSE: To determine the repeatability and agreement between the noninvasive Keratograph tear break-up time (NIK-BUT) as measured by the Oculus Keratograph 4 and fluorescein tear break-up time (FBUT). METHODS: Sixty subjects were recruited for two study visits separated by 7 (± 2) days. At each visit, three NIK-BUT measures and FBUT measures were obtained. Each NIK-BUT measure from the Keratograph included a first and an average NIK-BUT. The means of the measures obtained, first NIK-BUT, and average NIK-BUT and FBUT were calculated for each visit...
September 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Suqian Wu, Jiaxu Hong, Lijia Tian, Xinhan Cui, Xinghuai Sun, Jianjiang Xu
PURPOSE: To determine the validity and reliability of the clinical assessment of bulbar redness (BR) using a newly developed corneal topographer. METHODS: This is a cross-sectional diagnostic evaluation study. The BR scores [Oculus Index (OI)] from 30 eyes of 26 patients with different degrees of conjunctival hyperemia were assessed and scored automatically using a new method: a keratograph equipped with scanning and scoring software. The values obtained via this system were correlated with three image-based comparative subjective scales: the Institute for Eye Research (IER), the Efron, and the Validated Bulbar Redness (VBR) grading scales...
August 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Jonas Vejvad Nørskov Laursen, Peter Jeppesen, Thomas Olsen
To compare the precision among currently available keratometry devices. The corneal power was measured on two separate visits with the Nidek TonoRef II Autorefractor/Keratometer, the Zeiss IOLMaster 500, the Haag-Streit Lenstar LS 900, the Oculus Pentacam, and the Oculus Keratograph 4M. The precision was evaluated as the mean absolute intersession difference (MAD) between the corneal power measurements for each patient. Only the non-operated eye was included in the study. The Keratograph was found to have the highest MAD (0...
February 2016: International Ophthalmology
Pedro Arriola-Villalobos, José Ignacio Fernández-Vigo, David Díaz-Valle, Jorge E Peraza-Nieves, Cristina Fernández-Pérez, José M Benítez-Del-Castillo
AIMS: To compare intraobserver repeatability and interobserver and intersession reproducibility of lower tear meniscus height measurements (LTMH) obtained with the new Keratograph 5M and a Fourier-domain optical-coherence tomography (OCT; Spectralis OCT) and to assess the agreement between the two devices. METHODS: This is a observational cross-sectional study. Thirty eyes of 30 normal subjects were randomly imaged twice with both devices in our setting. Two examiners randomly made LTMH measurements using the devices...
August 2015: British Journal of Ophthalmology
Kara L Menzies, Sruthi Srinivasan, C Lisa Prokopich, Lyndon Jones
PURPOSE: The purpose of this study was to evaluate meibomian gland dropout and lipid layer thickness (LLT) in patients with and without Sjögren's syndrome dry eye (SS). METHODS: We recruited 11 participants with SS (males/females [M/F], 1:10; mean age = 56.0 ± 9.1 years) and 10 control subjects without dry eye (M/F, 3:7; mean age = 58.5 ± 4.7 years). All participants completed the Ocular Surface Disease Index (OSDI) questionnaire. The LLT was assessed using the Tearscope Plus based on the appearance of the lipid layer...
February 2015: Investigative Ophthalmology & Visual Science
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