keyword
https://read.qxmd.com/read/38525592/udp-glucose-p2y14-receptor-signaling-exacerbates-neuronal-apoptosis-after-subarachnoid-hemorrhage-in-rats
#1
JOURNAL ARTICLE
Hideki Kanamaru, Shiyi Zhu, Siyuan Dong, Yushin Takemoto, Lei Huang, Prativa Sherchan, Hidenori Suzuki, Jiping Tang, John H Zhang
BACKGROUND: Subarachnoid hemorrhage (SAH) is a severe subtype of stroke with poor outcomes. Abnormal glucose metabolism often occurs after SAH, but the strict control of blood glucose levels is not always beneficial. This study aimed to investigate the contribution of uridine diphosphate glucose (UDP-G), an intermediate of glucose/glycogen metabolism, and its receptor P2Y14 (P2Y purinoceptor 14) to SAH pathology and explored the potential targeted treatments in rats. METHODS: A total of 218 Sprague-Dawley male rats were used...
March 25, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38515613/what-are-the-available-online-resources-targeting-psychosocial-burden-among-stroke-survivors-and-their-informal-caregivers-a-scoping-review
#2
REVIEW
Marion Delvallée, Romain Garreau, Anne Termoz, Pierre-Marie Ploteau, Laurent Derex, Anne-Marie Schott, Julie Haesebaert
BACKGROUND: After discharge home, stroke survivors and their informal caregivers face a significant lack of support and information which accentuates their psychosocial burden. Online resources might provide this support and address psychosocial needs, but existing online stroke programmes mainly target functional rehabilitation. We aimed to map the existing literature on online resources that have been evaluated in stroke rehabilitation and aimed at reducing psychosocial impact in stroke survivors and informal caregivers...
2024: Digital Health
https://read.qxmd.com/read/38514230/pathophysiology-assessment-and-management-of-post-stroke-cognitive-impairment-depression-and-fatigue
#3
REVIEW
Abhishek Jaywant, Alexandra Keenan
Post-stroke cognitive impairment, depression, and fatigue are common, persistent, and disabling. This review summarizes current knowledge on the pathophysiology, assessment, and management of these debilitating neuropsychiatric sequelae of stroke. We briefly review evolving knowledge on the neural mechanisms and risk factors for each condition. We describe patient-reported outcome measures and clinician rating techniques that can be used to assist in screening and comprehensive assessment. We then discuss behavioral and pharmacologic management strategies...
May 2024: Physical Medicine and Rehabilitation Clinics of North America
https://read.qxmd.com/read/38512529/efficacy-of-rtms-in-treating-functional-impairment-in-post-stroke-patients-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Xiaodong Duan, Delong Huang, Haoshu Zhong, Junhao Wu, Zhihan Xiao, Peng Yang, Yuanhang Han, Haodong Jiang, Ping Zhou, Xi Liu
BACKGROUND: Most stroke patients suffer from an imbalance in blood supply, which causes severe brain damage leading to functional deficits in motor, sensory, swallowing, cognitive, emotional, and speech functions. Repetitive transcranial magnetic stimulation (rTMS) is thought to restore functions impaired during the stroke process and improve the quality of life of stroke patients. However, the efficacy of rTMS in treating post-stroke function impairment varies significantly. Therefore, we conducted a meta-analysis of the number of patients with effective rTMS in treating post-stroke dysfunction...
March 21, 2024: Neurological Sciences
https://read.qxmd.com/read/38509780/assessing-care-dependence-status-and-associated-influencing-factors-among-middle-aged-hemiplegic-stroke-patients-during-the-post-acute-rehabilitation-phase-a-correlational-study
#5
JOURNAL ARTICLE
Lianfeng Yuan, Jun Shen, Shan Ye, Na Zhou
AIMS: To comprehensively examine the prevailing condition of care dependence among middle-aged individuals who have experienced hemiplegia subsequent to a stroke and were currently undergoing post-acute rehabilitation. Additionally, the study sought to analyse the determinants that impacted this phenomenon. DESIGN: A single-centre, cross-sectional study design. METHODS: During the period from January 2020 to October 2022, a cohort of 196 hemiplegic stroke patients, aged between 40 and 65, and within 6 months of their stroke onset, was selected from the cerebrovascular outpatient clinic at a tertiary hospital in Hangzhou...
March 21, 2024: Journal of Clinical Nursing
https://read.qxmd.com/read/38505946/wellbeing-after-stroke-waters-feasibility-testing-of-a-co-developed-acceptance-and-commitment-therapy-intervention-to-support-psychological-adjustment-after-stroke
#6
JOURNAL ARTICLE
Emma Patchwood, Hannah Foote, Andy Vail, Sarah Cotterill, Geoff Hill, Audrey Bowen
OBJECTIVE: Feasibility test a co-developed intervention based on Acceptance and Commitment Therapy to support psychological adjustment post-stroke, delivered by a workforce with community in-reach. DESIGN: Observational feasibility study utilising patient, carer, public involvement. SETTING: Online. UK. PARTICIPANTS: Stroke survivors with self-reported psychological distress 4  +  months post-stroke...
March 20, 2024: Clinical Rehabilitation
https://read.qxmd.com/read/38501427/-modulating-gut-microbiota-improves-neurological-function-and-depressive-symptoms-in-rats-with-post-stroke-depression
#7
JOURNAL ARTICLE
X Li, Y Liu, K Deng, Y Hu
OBJECTIVE: To evaluate the effect of modulating gut microbiota for improving brain injury in rats with post-stroke depression. METHODS: Adult SD rats were randomized into normal control, middle cerebral artery occlusion (MCAO), post-stroke depression (PSD), PSD with fecal transplantation, PSD with antibiotics (rifaximin), PSD with probiotics (lactobacilli), and PSD with fluoxetine treatment groups ( n =9). Neurological function scores of the rats were determined, and the changes in sugar water preference and immobility time in forced swimming test were observed; plasma levels of trimethylamine N-oxide (TMAO) and hydrogen sulfide (H2S) were detected with ELISA, Occludin, and the expressions of occludin, caudin-5 and IgG proteins Ⅰ the brain tissues were determined using Western blotting...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38497332/individual-patient-data-meta-analysis-of-the-effects-of-fluoxetine-on-functional-outcomes-after-acute-stroke
#8
JOURNAL ARTICLE
Gillian Elizabeth Mead, Catriona Graham, Erik Lundström, Graeme J Hankey, Maree L Hackett, Laurent Billot, Per Näsman, John Forbes, Martin Dennis
BACKGROUND: Three large randomised controlled trials of fluoxetine for stroke recovery have been performed. We perfomed an individual patient data meta-analysis (IPDM) on the combined data. METHODS: Fixed effects meta-analyses was performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity analysis, summary statistics from each trial were created and combined...
March 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38488118/post-stroke-dizziness-depression-and-anxiety
#9
REVIEW
Pan Gu, Yuchuan Ding, Mangal Ruchi, Jing Feng, Huimin Fan, Aminan Fayyaz, Xiaokun Geng
OBJECTIVE: Vestibular and psychiatric disorders are very closely related. Previous research shows that the discomfort and dysfunction caused by dizziness in patients can affect psychological processes, leading to anxiety and depression, and the irritation of anxiety and depression can aggravate the discomfort of dizziness. But the causal relationship between dizziness in the recovery period of stroke and Post-stroke depression (PSD) / Post-stroke anxiety (PSA) is not clear. Identifying the causal relationship between them can enable us to conduct more targeted treatments...
March 15, 2024: Neurological Research
https://read.qxmd.com/read/38471473/complications-of-implanted-vagus-nerve-stimulation-a-systematic-review-and-meta-analysis
#10
Roshini Kalagara, Susmita Chennareddy, Emma Reford, Abhiraj D Bhimani, Daniel D Cummins, Margaret H Downes, Jenna M Tosto, Joshua B Bederson, J Mocco, David Putrino, Christopher P Kellner, Fedor Panov
INTRODUCTION: Vagus Nerve Stimulation (VNS) has emerged as a promising tool in ischemic stroke rehabilitation. However, there has been no systematic review summarizing its adverse effects, critical information for patients and providers when obtaining informed consent for this novel treatment. This systematic review and meta-analysis reports the adverse effects of VNS. METHODS: A systematic review was performed in accordance with PRISMA guidelines to identify common complications after VNS therapy...
March 12, 2024: Cerebrovascular Diseases
https://read.qxmd.com/read/38458373/dynamics-of-perceived-social-isolation-secondary-conditions-and-daily-activity-patterns-among-individuals-with-stroke-a-network-analysis-of-ecological-momentary-assessment-data
#11
JOURNAL ARTICLE
Yun Shi, Mandy W M Fong, Christopher L Metts, Sherri L LaVela, Charles Bombardier, Lu Hu, Alex W K Wong
OBJECTIVE: To assess contemporaneous and temporal dynamics of perceived social isolation (PSI), secondary conditions, and daily activity patterns in individuals post-stroke. DESIGN: Longitudinal observational study using ecological momentary assessment (EMA) as a real-time assessment of an individual's lived experiences. We conducted dynamic network analyses to examine longitudinal associations among EMA variables. SETTINGS: Home and Community PARTICIPANTS: 202 individuals with mild-to-moderate chronic stroke (median age = 60 years; 45% female; 44% black; 90% ischemic stroke; median NIHSS score = 2) INTERVENTION: Not applicable MAIN OUTCOME MEASURES: EMA questions measured PSI, secondary conditions (pain, tiredness, stress, anxiety, worthlessness, difficulty concentrating, and cheerfulness), and daily activity patterns (being at home, being alone, and participating in productive activities)...
March 6, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38454893/psychotic-disorder-after-left-posterior-cerebral-artery-stroke-an-atypical-event
#12
JOURNAL ARTICLE
Henrique Nascimento, Bárbara Almeida
INTRODUCTION: Stroke survivors usually present physical and neuropsychiatric complications. Post-stroke psychosis (PSPsy) is a particularly neglected sequel despite its disruptive nature. OBJECTIVES: To present a case of early emerging neuropsychiatric symptoms following a left posterior cerebral artery (PCA) stroke. To review and discuss PSPsy clinical manifestations, pathophysiology, and clinical outcomes. CLINICAL CASE: A previously autonomous 68-year-old woman with vascular risk factors and depressive disorder presented to the emergency department with a 5-day history of disorientation, motor aphasia, and right hypoesthesia...
February 2024: Actas Españolas de Psiquiatría
https://read.qxmd.com/read/38452937/transcutaneous-auricular-vagus-nerve-stimulation-for-post-stroke-depression-a-double-blind-randomized-placebo-controlled-trial
#13
JOURNAL ARTICLE
Chang Liu, Hao Tang, Chang Liu, Jingxi Ma, Gang Liu, Lingchuan Niu, Changqing Li, Jiani Li
BACKGROUND: It is a well-established fact that post-stroke depression (PSD) is a prevalent condition that affects a significant proportion of individuals who have suffered a stroke. Hence, our research endeavors to explore the safety, efficacy and the potential molecular mechanism of transcutaneous auricular vagus nerve stimulation (ta-VNS) for the treatment of depression in PSD patients by conducting a double-blind, sham-controlled, randomized trial. METHODS: Patients who had experienced strokes and exhibited depressive symptoms, with a Hamilton Depression Scale (HAMD-17) score of ≥8 and met the DSM-IV criteria, were diagnosed with PSD...
March 5, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38444465/the-effectiveness-of-five-element-music-therapy-for-post-stroke-depression-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Kelong Zhong, Xuemei An, Yun Kong
INTRODUCTION: Five-element music therapy is widely utilized as a complementary approach in stroke rehabilitation, particularly for addressing post-stroke depression (PSD). This study systematically evaluates the clinical impact of five-element music therapy on individuals experiencing PSD. METHODS: A comprehensive search of nine electronic databases, encompassing published and unpublished gray literature up to February 15, 2022, was conducted. Two investigators independently reviewed and extracted data, evaluating bias risk according to predefined criteria...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38443730/paroxetine-effect-on-nerve-growth-factor-human-neurotrophin-4-brain-derived-neurotrophic-factor-levels-in-post-stroke-depression
#15
JOURNAL ARTICLE
Yuhua Jin, Lamei Yu, Yan Li
The aim of this study is to explore paroxetine's effect on nerve growth factor (NGF), human neurotrophin-4 (NT-4), and brain-derived neurotrophic factor (BDNF) levels in post-stroke depression. Ninety-two post-stroke depression patients from April 2021 to April 2023 in our hospital were selected and numbered 1 to 92 after enrollment. Forty-six patients with odd number and 46 patients with even number were, respectively, included in the control and observation group. In addition to basic treatment, control group was treated with flupentixol melitracen tablets orally, and observation group received paroxetine hydrochloride orally...
March 5, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38439657/the-reliability-validity-and-clinical-utility-of-the-clinical-outcomes-in-routine-evaluation-ten-item-version-core-10-in-post-acute-patients-with-stroke
#16
JOURNAL ARTICLE
Tom Steverson, Joseph Marsden, Joshua Blake
OBJECTIVE: To explore the validity, reliability, and clinical utility of the Clinical Outcomes in Routine Evaluation - ten-item version (CORE-10: a ten-item questionnaire designed to measure psychological distress) in a stroke inpatient sample and calculate reliable and clinically significant change scores. SETTING: A post-acute stroke rehabilitation ward in the East of England. PARTICIPANTS: A total of 53 patients with stroke, capable of completing the CORE-10 as part of their routine clinical assessment...
March 5, 2024: Clinical Rehabilitation
https://read.qxmd.com/read/38428325/behavioral-and-neuroanatomical-correlates-of-facial-emotion-processing-in-post-stroke-depression
#17
JOURNAL ARTICLE
Janusz L Koob, Maximilian Gorski, Sebastian Krick, Maike Mustin, Gereon R Fink, Christian Grefkes, Anne K Rehme
BACKGROUND: Emotion processing deficits are known to accompany depressive symptoms and are often seen in stroke patients. Little is known about the influence of post-stroke depressive (PSD) symptoms and specific brain lesions on altered emotion processing abilities and how these phenomena develop over time. This potential relationship may impact post-stroke rehabilitation of neurological and psychosocial function. To address this scientific gap, we investigated the relationship between PSD symptoms and emotion processing abilities in a longitudinal study design from the first days post-stroke into the early chronic phase...
February 27, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38425239/post-stroke-cognitive-impairment-remains-highly-prevalent-and-disabling-despite-state-of-the-art-stroke-treatment
#18
JOURNAL ARTICLE
Laura Gallucci, Christoph Sperber, Adrian G Guggisberg, Christoph P Kaller, Mirjam R Heldner, Andreas U Monsch, Arsany Hakim, Norbert Silimon, Urs Fischer, Marcel Arnold, Roza Umarova
BACKGROUND: State-of-the-art stroke treatment significantly reduces lesion size and stroke severity, but it remains unclear whether these therapeutic advances have diminished the burden of post-stroke cognitive impairment (PSCI). AIMS: In a cohort of patients receiving modern state-of-the-art stroke care including endovascular therapy, we assessed the frequency of PSCI and the pattern of domain-specific cognitive deficits, identified risk factors for PSCI, and determined the impact of acute PSCI on stroke outcome...
March 1, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38423239/the-expression-of-probdnf-and-its-high-affinity-receptor-p75ntr-in-the-neurons-of-emotion-related-brain-regions-of-post-stroke-depression-rats
#19
JOURNAL ARTICLE
Xue-Ping Yang, Dan-Dai, Ruo-Xia Chen, Yu-Xuan Li, Xue Rui Lv, Yun Li
OBJECTIVE: To investigate the expression of the precursor of brain-derived neurotrophic factor (proBDNF) and its high-affinity receptor p75NTR in neurons of emotion-related brain areas (prefrontal cortex, hippocampus, and amygdala) in rats with post-stroke depression (PSD), and to explore the expression levels of proBDNF and p75NTR in neurons of emotion-related brain areas by injecting tissue plasminogen activator (t-PA) into the lateral ventricle of PSD rats, this significantly improved the stress-induced depression-like behavior,thus further validating the above results...
February 27, 2024: Brain Research
https://read.qxmd.com/read/38423194/alteration-of-gut-microbiota-in-post-stroke-depression-patients-with-helicobacter-pylori-infection
#20
JOURNAL ARTICLE
Mei Sun, Han Chen, Siyu Dong, Guoxin Zhang, Xiaoying Zhou, Hong Cheng
BACKGROUND: Several studies have identified an association between the gut microbiome and post-stroke depression(PSD), and Helicobacter pylori(H. pylori) infection cause significant alterations in the composition of the gastrointestinal microbiome. However, evidence regarding the role of the H. pylori infection in promoting PSD is still lacking. Here, we conducted a retrospective study to explore risk factors associated with PSD. METHODS: Patients with cerebral infarction were consecutively enrolled from December 2021 to October 2022...
February 28, 2024: Neurobiology of Disease
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