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spinocellular carcinoma

H Burkhardt, P Weisenseel, M A Radtke, K Krüger
For the clinical practice there is uncertainty as to what degree the therapeutic immunomodulation of rheumatoid arthritis (RA) is associated with a weakening of protective tumor immunity. Neoplasms of the skin in particular are known to exhibit increased incidence rates in association with therapeutic immunosuppression in transplantation medicine; however, the immunosuppression required for the prevention of allogenic graft rejection is much more intensive and thus not directly transferable to the potential risks for an onset or relapse of melanoma or non-melanoma skin cancers (NMSC), e...
February 2016: Zeitschrift Für Rheumatologie
P Kuglik, K Kasikova, J Smetana, V Vallova, A Lastuvkova, L Moukova, M Cvanova, L Brozova
UNLABELLED: It is known that cervical cancer develop from precancerous intraepithelial neoplasia (CIN) which is characterized by series of genetic abnormalities. The progression of CIN to cervical carcinoma has been associated especially with the genomic integration of oncogenic human papilloma virus (HPV) and gain of the human telomerase RNA gene hTERC (3q26) and MYC (8q24). In this study, cytology specimens of cervical intraepithelial neoplasia and cervical carcinoma from 74 Czech women were analyzed using the triple-color Cervical FISH Probe Kit designed for identification of HPV infected cells and copy number aberration of the hTERC and MYC genes...
2015: Neoplasma
Anne Kristine Larsen, Anna Marie Nielsen
Marjolin's ulcer (MU) is a malignant degeneration of a chronic wound and spinocellular carcinoma is the most common type. MU is described as being aggressive in nature and carries a high incidence of metastases. A 71-year-old man developed spinocellular carcinoma 54 years after a primary amputation and a construction of a skin graft due to a severe foot trauma. The carcinoma was excised and a forefoot amputation was performed.
December 15, 2014: Ugeskrift for Laeger
Alberto Oldani, Sergio Gentilli, Manuela Monni, Paolo Bellora, Glenda Grossi, Caterina Casadio, Marcello Garavoglia
AIM: To describe the case of a thymic carcinoma with atypical clinical behavior that has arisen with a voluminous metastasis at the right hemidiaphragm while the primitive thymic neoplasm was initially occult. CASE REPORT: A 42 years female patient came to clinical observation for a voluminous thoraco-abdominal mass located in right side, infiltrating the diaphragm. The patient was submitted to surgical excision of the mass; definitive histological examination: non-keratinizing spinocellular carcinoma suggestive for neoplasia on ectopic thymic tissue or metastasis from carcinoma of the thymus...
2014: Annali Italiani di Chirurgia
Jean-Benoît Courcet, Siham Chafai Elalaoui, Laurence Duplomb, Mariam Tajir, Jean-Baptiste Rivière, Julien Thevenon, Nadège Gigot, Nathalie Marle, Bernard Aral, Yannis Duffourd, Alain Sarasin, Valeria Naim, Emilie Courcet-Degrolard, Marie-Hélène Aubriot-Lorton, Laurent Martin, Jamal Eddin Abrid, Christel Thauvin, Abdelaziz Sefiani, Pierre Vabres, Laurence Faivre
SASH1 (SAM and SH3 domain-containing protein 1) is a tumor suppressor gene involved in the tumorigenesis of a spectrum of solid cancers. Heterozygous SASH1 variants are known to cause autosomal-dominant dyschromatosis. Homozygosity mapping and whole-exome sequencing were performed in a consanguineous Moroccan family with two affected siblings presenting an unclassified phenotype associating an abnormal pigmentation pattern (hypo- and hyperpigmented macules of the trunk and face and areas of reticular hypo- and hyperpigmentation of the extremities), alopecia, palmoplantar keratoderma, ungueal dystrophy and recurrent spinocellular carcinoma...
July 2015: European Journal of Human Genetics: EJHG
Pedro G Ferreira, Lina Carvalho, Fernanda Gamboa
Case report of a male patient with a five-decade follow-up history in a tertiary care hospital distinguished for malabsorption syndrome, failure-to-thrive, meningitis and recurrent bacterial, fungal and mycobacterial pulmonary infections. Additionally, he developed epidermodysplasia verruciformis, several in situ spinocellular carcinomas and an uncharacteristic parenchymal lung disease. Surgical lung biopsy suggested pulmonary alveolar proteinosis with fibrotic change. Retrospectively, severe monocytopenia had been overlooked in the past, as well as low B and NK cell blood counts...
September 2014: Revista Portuguesa de Pneumologia
G Paolino, C Panetta, C Cota, L Muscardin, P Donati, A Di Carlo
AIM AND METHODS: We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous-hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females...
December 2013: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Giacomo Maria Pirola, Giovanni Saredi, Giuseppe Damiano, Alberto Mario Marconi
PURPOSE: To review the 10-year experience of our urological unit in the surgical management of renal cell carcinoma (RCC) with neoplastic tumor thrombosis focusing on postoperative survival. MATERIALS AND METHODS: We underwent a retrospective analysis of the patients treated for this pathology during the last decade 2002-2012, stratifying them by tumor thrombus level and histological subtype. Kaplan-Meyer curves were used to assess survival. RESULTS: Overall, 67 patients underwent surgery for RCC with neoplastic tumoral thrombosis in the period under review...
December 2013: Archivio Italiano di Urologia, Andrologia
J Lamy, A Gourari, M Atlan, G Zakine
INTRODUCTION: Dermal substitute are used for soft-tissue defect for their functional and aesthetic advantages. Matriderm® 1mm, single layer dermal matrix, composed of collagen and elastin covered by a split thickness skin graft simultaneously to its application, has been used most often in burned surgery. This prospective series evaluates the interest of this recent dermal matrix in reconstructive surgery. PATIENTS AND METHOD: Twenty-eight patients have been treated with the substitute in our department for reconstructive surgery indication between November 2008 and May 2012...
June 2013: Annales de Chirurgie Plastique et Esthétique
Maria Giuseppina Onesti, Antonietta Troccola, Michele Maruccia, Andrea Conversi, Gianluca Scuderi
Chalazion is a subacute granulomatous inflammation of the eyelid caused by retention of tarsal gland secretions and it's the most common inflammatory lesion of the eyelid. In cases of doubtful clinical presentation the diagnosis with a biopsy and a histopathological examination is important because it can orientate an appropriate surgical treatment. We report a case of a 64-years-old diabetic man, suspected for a spinocellular lesion of the inferior eyelid of the left eye, it resulted unexpectedly a chalazion...
2013: Annali Italiani di Chirurgia
P Dierks, W Wiegand
The case of a 73-year-old woman with a perforated corneal ulcer in the remaining eye with migrating endophthalmitis is presented. In addition, the affected eye had non-abradable whitish coating (leukoplakia) on the tarsal conjunctiva. The cause of leukoplakia was initially histologically diagnosed after an incisional biopsy as focal invasive sebaceous carcinoma with pagetoid growth. After exenteration of the orbit it was confirmed to be an early invasive, non-keratinizing squamous cell carcinoma (G2) of the conjunctiva, which had emerged from a spinocellular carcinoma in situ...
October 2012: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Karol Zeleník, Jana Kukutschová, Jana Dvořáčková, Hana Bielniková, Pavlína Peikertová, Lenka Cábalová, Pavel Komínek
This study aimed to evaluate the palatine tonsils of patients with chronic tonsillitis and spinocellular carcinoma to determine the presence of nano-sized particles. Tonsil samples from adult patients with chronic tonsillitis and spinocellular carcinoma of the palatine tonsil were dried and analyzed using a scanning electron microscope with the X-ray microprobe of an energy-dispersive spectroscope. Demographic data and smoking histories were obtained. The principal metals found in almost all tissues analyzed were iron, chromium, nickel, aluminum, zinc, and copper...
February 2013: European Archives of Oto-rhino-laryngology
N Lazarov, L Lazarov, S Lazarov
The authors present a case of a 35 years old female patient with spinocellular carcinoma of the cervix, diagnosed after byopsy and treated with radiotherapy 30 Gray, combined with Cisplatin 50 mg. per square meter, per week, 6 months before radical histerectomy and lymphonodulectomy was performed. The postoperative histology shows only traces of dysplastic epithelia, which proves preoperative therapy effective.
2012: Akusherstvo i Ginekologii︠a︡
E Pampana, R Gandini, M Stefanini, S Fabiano, A Chiaravalloti, D Morosetti, S Spano, G Simonetti
"Carotid blowout syndrome" is defined as a hemorrhage caused by rupture of the carotid artery and its branches, and may be a severe complication of rhinopharyngeal carcinoma. This study aimed to highlight the usefulness and versatility of endovascular stent-graft placement as a rescue treatment in life-threatening carotid blowout syndrome. We describe the unconventional use of a 6 × 5 mm balloon-expandable coronaric covered stent in a patient with a diagnosis of spinocellular rhinopharyngeal carcinoma, followed by carotid blowout syndrome...
December 2011: Interventional Neuroradiology
Bogusław Antoszewski, Anna Kasielska, Marta Fijałkowska
UNLABELLED: The most common skin neoplasms are carcinoma: basocellulare, spinocellulare, planoepitheliale and melanoma malignum. Early surgical treatment is crucial for recovery as well as for good aesthetic result, especially on exposed body parts. All those lesions are visible for observers and the time from their appearance to surgical treatment seems to be too long. The aim of the study was to answer the following questions: 1. After what time from the skin lesion appearance the patients report to a surgeon? 2...
July 2011: Polski Przeglad Chirurgiczny
Costanza Chiumento, Alba Fiorentino, Giovanni Castaldo, Vincenzo Fusco
AIMS AND BACKGROUND: Thyroid metastasis from nasopharyngeal carcinoma is a rare occurrence. We report a case of thyroid metastases from nasopharyngeal carcinoma with a review of the literature. METHODS: In April 2007 a 59-year-old man was diagnosed with nasopharyngeal carcinoma; in October 2009 he underwent a thyroid biopsy that revealed G2 infiltrating spinocellular carcinoma with lymph node involvement. He was treated with chemotherapy and radiotherapy at our institute...
September 2011: Tumori
Soraya Navysany, Edgar Dippel, Christoph Löser
No abstract text is available yet for this article.
January 2012: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
K Tourabi, H Mejjati, Y Ribqg, A Achbouk, A Arrob, A Moussaoui, H Ihrai
In order to study Marjolin's ulcer, all the case histories of patients admitted over a 5-yr period to a Service of Plastic Surgery and Burn Patients in Morocco presenting a histopathologically confirmed burn scar cancer were included in a data file with information regarding the medical background of the five patients concerned, their treatment, and the evolution of the case.After this data presentation, the problems set by spinocellular epithelioma, which is a serious and rare affection, are considered.The degeneration of burn scars is a dramatic development, caused by negligence...
December 31, 2009: Annals of Burns and Fire Disasters
Emmanuel Rodrigues de França, Márcia Almeida Galvão Teixeira, Kleber de Freitas Matias, Daniela Eugenia Costa Morais Antunes, Rafael de Almeida Braz, Claudia Elise Ferraz Silva
Hydroxyurea is an hydroxylated urea derivative used in many myeloproliferative disorders. Many, but unusual cutaneous disorders are related after its prolonged use. Their pathogenesis is not clear, but it is suggested that there is direct toxicity of the drug on the skin. We described a white, 75-year old man with diagnosis of Polycythemia Vera that in 11 years of treatment developed many cutaneous lesions: skin hyperpigmentation, atrophic lesions on forearms, longitudinal melanonychia of 20 nails, right forearm ulcer, cutaneous xerosis, ichthyosis and auricular spinocellular carcinoma...
July 2011: Anais Brasileiros de Dermatologia
S M Criscione
There is a very strong evidence that progression (also to cancer) in variable percentages of cases infected by HPV, HBV, HCV, and HIV depends on host immune response. A large number of observations demonstrate that virus set up a postulated "active strategy" to modify host reactions or to avoid it. But in all those infections it also seems that antigen load (viral RNA or DNA), chronic activation of immune response and time elapsing from the primary infection play a pivotal role in determining clearing or persisting outcomes...
November 2011: Medical Hypotheses
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