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Merkel carcinoma

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https://www.readbyqxmd.com/read/29040209/inherited-and-acquired-clinical-phenotypes-associated-with-neuroendocrine-tumors
#1
Rory E Nicholaides, M Teresa de la Morena
PURPOSE OF REVIEW: Overview of neuroendocrine neoplasms in the context of their associations with primary and secondary immunodeficiency states. RECENT FINDINGS: Malignancies of neuroendocrine origin are well known to be associated with hereditary syndromes, including multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis. This review includes the X-linked form of hyper-IgM syndrome (XHIGM), due to mutations in the CD40Ligand gene (CD40LG), as an additional inherited disorder with susceptibility to such malignancies, and discusses neuroendocrine tumors (NETs) arising in other immunocompromised states...
October 16, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29034299/a-case-of-merkel-cell-carcinoma-development-under-treatment-with-a-janus-kinase-inhibitor
#2
Yuta Koike, Naoya Murayama, Yutaka Kuwatsuka, Atsushi Utani
No abstract text is available yet for this article.
November 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/29033592/is-this-the-end-of-cytotoxic-chemotherapy-in-merkel-cell-carcinoma
#3
REVIEW
Guilherme Rabinowits
Although cytotoxic chemotherapy has been used often in the management of Merkel cell carcinoma (MCC), its benefit remains uncertain. Despite being considered a chemosensitive disease, the duration of response is generally short, and the survival benefit is unclear. With the recent FDA approval of the anti-programmed cell death ligand 1 (PD-L1) antibody avelumab for patients with advanced MCC and the limited and controversial data on chemotherapy, it is important to put in perspective whether conventional chemotherapy should remain an option for these patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#4
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29028833/merkel-cell-polyomavirus-recruits-mycl-to-the-ep400-complex-to-promote-oncogenesis
#5
Jingwei Cheng, Donglim Esther Park, Christian Berrios, Elizabeth A White, Reety Arora, Rosa Yoon, Timothy Branigan, Tengfei Xiao, Thomas Westerling, Alexander Federation, Rhamy Zeid, Benjamin Strober, Selene K Swanson, Laurence Florens, James E Bradner, Myles Brown, Peter M Howley, Megha Padi, Michael P Washburn, James A DeCaprio
Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor function, it is less clear how ST contributes to MCC tumorigenesis. Here we show that ST binds specifically to the MYC homolog MYCL (L-MYC) and recruits it to the 15-component EP400 histone acetyltransferase and chromatin remodeling complex. We performed a large-scale immunoprecipitation for ST and identified co-precipitating proteins by mass spectrometry...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29019175/isolated-limb-infusion-a-single-center-experience-with-over-200-infusions
#6
Cristina O'Donoghue, Matthew C Perez, John E Mullinax, Danielle Hardman, Sean Sileno, Syeda Mahrukh Hussnain Naqvi, Youngchul Kim, Ricardo J Gonzalez, Jonathan S Zager
BACKGROUND: Isolated limb infusion (ILI) is a minimally invasive technique for delivering regional chemotherapy to an extremity for patients with locally advanced cutaneous malignancies and sarcoma. METHODS: A single-institution, prospectively collected database was analyzed for intention-to-treat with ILI. RESULTS: From 2007 to 2016, 163 patients underwent 205 procedures (201 were successfully completed), and four malignancies were treated: melanoma (72...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28989113/utilization-patterns-and-survival-outcomes-after-wide-local-excision-or-mohs-micrographic-surgery-for-merkel-cell-carcinoma-in-the-united-states-2004-2009
#7
Waqas R Shaikh, Joseph F Sobanko, Jeremy R Etzkorn, Thuzar M Shin, Christopher J Miller
No abstract text is available yet for this article.
October 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28985829/case-series-merkel-cell-carcinoma-of-the-eyelid
#8
Cristina Bostan, Mariana Botelho Dias de Souza, Pablo Zoroquiain, Luiz Augusto Guimarães de Souza, Miguel N Burnier
No abstract text is available yet for this article.
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28981217/incurable-progressive-merkel-cell-carcinoma-a-single-institution-study-of-54-cases
#9
Alexandra Fochtmann-Frana, Georg Haymerle, Robert Loewe, Matthaeus Ch Grasl, Johannes Pammer, Thomas Rath, Christos Perisanidis, Boban M Erovic
The median overall survival, disease-free survival and survival from disease progression of patients with progressive disease was 15, 8 months and 5 months, respectively. 22 (96%) out of 23 individuals suffering from disease progression died of the disease. The overall mortality rate was 70%. Patients with progressive MCC spend significantly more tumour related days in the hospital compared to patients without a progressive disease. The rate of immunosuppression was significantly higher in the MCC progressive group and those patients received more often radio- and/or chemotherapy...
October 5, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28980225/merkel-cell-carcinoma-of-the-buccal-mucosa-and-lower-lip
#10
Mohammed N Islam, Hardeep Chehal, Molly Housley Smith, Sarah Islam, Indraneel Bhattacharyya
Merkel cell carcinoma (MCC) is an uncommon relatively aggressive neuroendocrine dermal neoplasm first described in 1972 as a tumor of the sun exposed skin. Although most MCC affect the skin of the head and neck, rare primarily oral mucosal cases have been documented. Merkel cells are nondendritic neuroendocrine cells that are found not only in the skin but also the oral mucosa and give rise to MCC. Neuroendocrine cells may be found as aggregates in organs or as diffuse or isolated cells within organs and their epithelial lining...
October 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28976209/avelumab-and-other-recent-advances-in-merkel-cell-carcinoma
#11
Praveen K Bommareddy, Howard L Kaufman
Merkel-cell carcinoma (MCC) is a rare but aggressive form of skin cancer that occurs in the elderly, is associated with UV radiation and immunosuppression. Initial treatment consists of wide excision with adjuvant radiation. Although the tumor is sensitive to chemotherapy, long-term survival is unusual and there had been no US FDA-approved drugs prior to 2017. The recognition that MCC is associated with the Merkel cell polyomavirus occurs more commonly in immune-compromised patients and tumors express PD-L1 suggested testing immunotherapy...
October 4, 2017: Future Oncology
https://www.readbyqxmd.com/read/28969748/primary-merkel-cell-carcinoma-on-the-cheek-three-case-reports
#12
Tao Fan, Ying Jie Song, Xiu Li Liu, Jun Zhou, Hong Yang, Ya Nan Wei, Chao Qi Wang
Merkel cell carcinoma (MCC) is a rare aggressive cutaneous neuroendocrine carcinoma that typically arises in sunexposed areas of the skin. Herein, we present three cases of primary MCC of the cheek. Case 1 had multiple nodules and mild swelling on the left cheek and eyelids, the patient did not receive any treatment and died after 10 months. Case 2 presented with nodule on patient's left cheek, which increased gradually. The patient was treated with surgical resection from the tumor edge 0.3 cm and skin flap transplantation, she died after 21 months...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28966943/understanding-the-influence-of-patient-demographics-on-disease-severity-treatment-strategy-and-survival-outcomes-in-merkel-cell-carcinoma-a-surveillance-epidemiology-and-end-results-study
#13
Harib H Ezaldein, Alessandra Ventura, Nicolaas P DeRuyter, Emily S Yin, Alessandro Giunta
OBJECTIVE: To identify trends in patient presentation and outcomes data that may guide the development of clinical algorithms on Merkel Cell Carcinoma (MCC). METHODS: We performed a retrospective cohort study searching in the National Cancer Institute's SEER registry for documented MCC cases from 1986-2013. No exclusion criteria were applied. We hereby identified 7,831 original MCC entries. Demographics, staging, and socioeconomic characteristics were identified and treatment modality likelihoods and survival data were calculated via logistic regression and Kaplan-Meier statistical modeling...
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28961284/aggressive-merkel-cell-carcinoma-in-a-liver-transplant-recipient
#14
Jasmine Obioha, Sheryl Miller
Merkel cell carcinoma (MCC) is a rare aggressive cutaneous tumor that commonly occurs in sun-exposed sites. It has a tendency for rapid growth, local recurrence, lymph node invasion, and distant metastases. Risk factors include immunosuppression, advanced age, exposure to UV radiation, and infection with the Merkel cell polyomavirus. We report a case of a 67-year-old woman with rapidly aggressive MCC 6 years after liver transplantation.
August 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28960348/low-viral-load-of-merkel-cell-polyomavirus-in-iranian-patients-with-head-and-neck-squamous-cell-carcinoma-is-it-clinically-important
#15
Elham Mohebbi, Zahra Noormohamadi, Habib Sadeghi Rad, Farzin Sadeghi, Yousef Yahyapour, Farzam Vaziri, Ayoub Rahimi, Fatemeh Rahimi Jamnani, Saman Mehrabi, Seyed Davar Siadat, Mohammad Reza Noori-Daloii, Abolfazl Fateh
Recent studies show that the human Merkel cell polyomavirus (MCPyV) may be involved in causing cancer. The objective of this study was to assess the impact of MCPyV on the development of head and neck squamous cell carcinoma (HNSCC). Totally, 50 paraffin-embedded HNSCC biopsy samples and 50 adjacent non-cancerous samples were evaluated for the presence of MCPyV DNA and RNA. Among patients, the five most frequent histopathologic sites were the tongue (22.0%), lip (16.0%), submandibular (14.0%), cheek (14.0%), and throat (14...
September 28, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28959124/higher-expression-of-activation-induced-cytidine-deaminase-is-significantly-associated-with-merkel-cell-polyomavirus-negative-merkel-cell-carcinomas
#16
Michiko Matsushita, Takeshi Iwasaki, Daisuke Nonaka, Satoshi Kuwamoto, Keiko Nagata, Masako Kato, Yukisato Kitamura, Kazuhiko Hayashi
BACKGROUND: Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and -negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma (HCV), and Burkitt lymphoma (EBV)...
September 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28951515/merkel-cell-carcinoma-cardiac-metastasis-causing-cardiac-tamponade
#17
Murray Di Loreto, Roslyn Francis
We describe an unusual presentation of Merkel cell carcinoma (MCC), a rare neuroendocrine cutaneous tumour. A 59-year-old man presented with a 2-week history of dyspnoea on a background of MCC of the left elbow that was diagnosed after an axillary lymph node metastasis had appeared. He was clinically diagnosed with cardiac tamponade and received urgent pericardiocentesis. Thoracic CT imaging revealed a large infiltrating mass within the inferior aspect of the heart, confirmed to be MCC via immunohistochemistry of the pericardial fluid...
September 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28950303/checkpoint-blockade-for-metastatic-melanoma-and-merkel-cell-carcinoma-in-hiv-positive-patients
#18
M V Heppt, M Schlaak, T K Eigentler, K C Kähler, F Kiecker, C Loquai, F Meier, D Tomsitz, N Brenner, A C Niesert, R Thonke, A Hauschild, C Berking
No abstract text is available yet for this article.
September 18, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28937781/-lymph-node-metastasis-of-merkel-cell-carcinoma-without-known-cutaneous-primary-case-report
#19
Arpád Szabó, Igor Richter, Dana Frydrychová, Martina Saláková, Tomáš Jirásek
Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary. In this report we present the case of a 42 year-old man with inguinal lymphadenopathy, histologically consistent with Merkel cell carcinoma. Tumor cells expressed immunohistochemically chromogranin-A, synaptophysin and displayed dot-like positivity for cytokeratin 20...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28931417/sentinel-lymph-node-biopsy-in-periocular-merkel-cell-carcinoma-a-case-report
#20
Dan C Filitis, Gyorgy Paragh, Faramarz H Samie, Nathalie C Zeitouni
BACKGROUND: The National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic. CASE PRESENTATION: We present a case of a Caucasian patient in their seventies who presented with a 1...
September 20, 2017: BMC Research Notes
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