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Merkel carcinoma

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https://www.readbyqxmd.com/read/29220526/anti-pd-l1-treatment-induced-central-diabetes-insipidus
#1
Chen Zhao, Sri Harsha Tella, Jaydira Del Rivero, Anuhya Kommalapati, Ifechukwude Ebenuwa, James Gulley, Julius Strauss, Isaac Brownell
Context: Immune checkpoint inhibitors, including anti-PD-1, anti-PD-L1 and anti-CTLA4 monoclonal antibodies, have been widely used in cancer treatment. They are known to cause immune-related adverse events (irAEs), which resemble autoimmune diseases. Anterior pituitary hypophysitis with secondary hypopituitarism is a frequently reported irAE, especially in patients receiving anti-CTLA4 treatment. In contrast, posterior pituitary involvement, such as central diabetes insipidus (DI), is relatively rare and is unreported in patients undergoing PD-1/PD-L1 blockade...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29219612/nonprogression-with-avelumab-treatment-associated-with-gains-in-quality-of-life-in-metastatic-merkel-cell-carcinoma
#2
Howard L Kaufman, Matthias Hunger, Meliessa Hennessy, Michael Schlichting, Murtuza Bharmal
AIM: To assess the association between tumor response and health-related quality of life (HRQoL) in patients with metastatic Merkel cell carcinoma treated with the anti-PD-L1 avelumab. MATERIALS & METHODS: Phase II single-arm trial (NCT02155647) data of 88 patients were analyzed. Correlations between percentage reduction in tumor size and change from baseline in Functional Assessment of Cancer Therapy - General (FACT-G), FACT - Melanoma (FACT-M) and EuroQol-5 Dimension scores were calculated...
December 8, 2017: Future Oncology
https://www.readbyqxmd.com/read/29217732/peptide-blocking-of-pd-1-pd-l1-interaction-for-cancer-immunotherapy
#3
Chunlin Li, Nengpan Zhang, Jundong Zhou, Chen Ding, Yaqing Jin, Xueyuan Cui, Kefeng Pu, Yimin Zhu
Immunotherapy has become a promising alternative therapeutic approach for cancer patients. Interruption of immune checkpoints, such as CTLA-4 and PD-1, has been verified to be a successful means for cancer therapy in clinical trials. Monoclonal antibody (mAb) targeting to PD-L1 has been approved to treat urothelial carcinoma, non-small cell lung cancer or merkel cell carcinoma by the Food and Drug Administration (FDA). However, the high cost of the antibody can limit its application. In our study, TPP-1 (targeting PD-L1 peptide), which specifically binds to PD-L1 with high affinity, was identified through bacterial surface display methods...
December 7, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29217527/merkel-cell-carcinoma-in-the-age-of-immunotherapy-facts-and%C3%A2-hopes
#4
Aric Colunga, Thomas Pulliam, Paul Nghiem
Merkel cell carcinoma (MCC) is a rare (~2,000 US cases/year) but aggressive neuroendocrine tumor of the skin. For advanced MCC, cytotoxic chemotherapy only infrequently (<10% of cases) offers durable clinical responses (>1 year) suggesting a great need for improved therapeutic options. In 2008, the Merkel cell polyomavirus (MCPyV) was discovered and is clonally integrated in ~80% of MCC tumors. The remaining 20% of MCC tumors have large numbers of UV-associated mutations. Importantly, both the UV-induced-neoantigens in virus-negative tumors and the MCPyV T antigen oncogenes that are required for virus-positive tumor growth are immunogenic...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29217440/endolymphatic-balloon-occluded-retrograde-abdominal-lymphangiography-boral-and-embolization-borale-for-the-diagnosis-and-treatment-of-chylous-ascites-technique-and-experience-in-three-patients
#5
Ravi N Srinivasa, Joseph J Gemmete, Matthew L Osher, Jeffrey Forris Beecham Chick
PURPOSE: To describe endolymphatic balloon-occluded retrograde abdominal lymphangiography (BORAL) and embolization (BORALE) for diagnosis and treatment of chylous ascites in patients with previously unidentifiable leakage site or failed lymphatic embolization. MATERIALS AND METHODS: Two (66%) men and one (33%) woman with mean age of 52 years (range: range: 14-79 years) presented with chylous ascites and underwent BORAL or BORALE between March 2016 and February 2017...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29203339/head-and-neck-merkel-cell-carcinoma-a-retrospective-case-series-and-critical-literature-review-with-emphasis-on-treatment-and-prognosis
#6
Ioannis Papadiochos, Anna Patrikidou, Aikaterini Patsatsi, Doxa Mangoudi, Henri Thuau, Konstantinos Vahtsevanos
OBJECTIVE: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with a high recurrence and mortality rates. More than half of MCCs occur in the head and neck region. This paper aims to present a retrospective case series study of primary MCCs of the head and neck treated in our department over 12 years. STUDY DESIGN: Six patients were identified, and their characteristics, treatment modalities, and outcomes are reported. A critical review of the current literature is also included to provide up-to-date information on MCCs with special emphasis on treatment modalities and disease prognosis...
December 1, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29188306/epidemiology-biology-and-therapy-of-merkel-cell-carcinoma-conclusions-from-the-eu-project-immomec
#7
REVIEW
Jürgen C Becker, Andreas Stang, Axel Zur Hausen, Nicole Fischer, James A DeCaprio, Richard W Tothill, Rikke Lyngaa, Ulla Kring Hansen, Cathrin Ritter, Paul Nghiem, Christopher K Bichakjian, Selma Ugurel, David Schrama
Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations affect comparable signaling pathways such as RB restriction of cell cycle progression or p53 inactivation. Despite its low incidence, MCC recently received much attention based on its exquisite immunogenicity and the resulting major success of immune modulating therapies...
November 30, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29186254/merkel-cell-carcinoma-in-an-immunosuppressed-patient
#8
Heliana Freitas de Oliveira Góes, Caren Dos Santos Lima, Maria Cláudia de Almeida Issa, Flávio Barbosa Luz, Luciana Pantaleão, José Gabriel Miranda da Paixão
Merkel cell carcinoma is an uncommon neuroendocrine carcinoma with a rising incidence and an aggressive behavior. It predominantly occurs in older patients, with onset occurring at a mean age of 75-80 years. Recognized risk factors are ultraviolet sunlight exposure, immunosuppression, and, more recently, Merkel cell polyomavirus. We report a case of Merkel cell carcinoma in a young HIV positive patient with Merkel Cell polyomavirus detected in the tumor.
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29180096/differentiating-merkel-cell-carcinoma-of-lymph-nodes-without-a-detectable-primary-skin-tumor-from-other-metastatic-neuroendocrine-carcinomas-the-electhip-criteria
#9
Thibault Kervarrec, Julia Zaragoza, Pauline Gaboriaud, Amélie Le Gouge, Agnès Beby-Defaux, Yannick Le Corre, Eva Hainaut-Wierzbiecka, Francois Aubin, Guido Bens, Patrick Michenet, Hervé Maillard, Antoine Touzé, Mahtab Samimi, Serge Guyétant
BACKGROUND: Merkel cell carcinoma MCC) can present as a cutaneous tumor or a lymph node without primary tumor MCCWP). MCCWP can be misinterpreted on histologic examination as lymph node metastasis LNM) from other neuroendocrine carcinomas LNMNECs). However, this distinction is crucial for therapeutic management. OBJECTIVE: To determine the discriminative criteria for differential diagnosis between MCCWP, LNM from cutaneous MCC and LNMNECs. METHODS: Clinical, morphologic, immunohistochemical data expression of cytokeratin AE1/AE3, 7, 19, 20; chromogranin A, thyroid transcription factor-1 [TTF-1]) and presence of Merkel Cell Polyomavirus MCPyV) immunohistochemistry and PCR) were compared in patients with MCCWP n=17), LNM from cutaneous MCC n=11) and LNMNEC n=20: lung, n=8; thyroid, n=7; digestive tract, n=3; other, n=2)...
November 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29177692/dermatological-complications-after-solid-organ-transplantation
#10
REVIEW
Luigi Naldi, Anna Venturuzzo, Pietro Invernizzi
Organ transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e...
November 25, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29174934/primary-lesions-that-may-imitate-metastatic-tumors-histologically-a-selective-review
#11
REVIEW
Mark R Wick
Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones...
November 17, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29172995/pd-l1-blockade-with-avelumab-a-new-paradigm-for-treating-merkel-cell-carcinoma
#12
Savannah Barkdull, Isaac Brownell
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer. Until recently, no durable treatment options were available for patients with advanced disease. As an immunogenic cancer, MCC was hypothesized to be a candidate for PD-L1/PD-1 targeted therapy. On March 23, 2017 the US Food and Drug Administration granted accelerated approval for avelumab, an anti-PD-L1 monoclonal antibody, for the treatment of metastatic MCC on the basis of the JAVELIN Merkel 200 trial. Here we examine the results and implications of this pivotal study, published in Lancet Oncology by Kaufman et al...
November 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29167345/merkel-cell-polyomavirus-infection-of-animal-dermal-fibroblasts
#13
Wei Liu, Nathan A Krump, Margo MacDonald, Jianxin You
Merkel cell polyomavirus (MCPyV) is the first polyomavirus to be associated with human cancer. Mechanistic studies attempting to fully elucidate MCPyV oncogenic mechanisms have been hampered by the lack of animal models for MCPyV infection. In this study, we examined the infectability of MCPyV-GFP pseudovirus, MCPyV recombinant virion, and several MCPyV chimeric viruses in dermal fibroblasts isolated from various model animals, including mouse (Mus musculus), rabbit (Oryctolagus cuniculus), rat (Rattus norvegicus), chimpanzee (Pan troglodytes), rhesus macaque (Macaca mulatta), patas monkey (Erythrocebus patas), common woolly monkey (Lagothrix lagotricha), red-chested mustached tamarin (Saguinus labiatus), and tree shrew (Tupaia Belangeri)...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29166764/merkel-cell-carcinoma-metastatic-to-pleural-fluid-a-case-report
#14
Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional and distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases had been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC could give patients good chances to get recently advanced therapeutic options...
November 23, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29157891/surgical-resection-improves-median-overall-survival-with-marginal-improvement-in-long-term-survival-when-compared-with-definitive-radiotherapy-in-merkel-cell-carcinoma-a-propensity-score-matched-analysis-of-the-national-cancer-database
#15
G Paul Wright, Matthew P Holtzman
BACKGROUND: Definitive radiotherapy has been suggested as a treatment alternative to surgical resection in Merkel cell carcinoma (MCC). METHODS: Patients with MCC were identified from the National Cancer Database. Propensity score matching accounting for age, Charlson-Deyo score, grade, and AJCC stage was used to match patients in 1:1 fashion by primary treatment (surgery vs. radiotherapy). RESULTS: There were 1227 patients in each group. Median overall survival was improved with surgical resection in stage I/II (76 vs...
November 11, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29148079/insm1-a-novel-nuclear-marker-in-merkel-cell-carcinoma-cutaneous-neuroendocrine-carcinoma
#16
Patrick S Rush, Jason N Rosenbaum, Madhuchhanda Roy, Rebecca M Baus, Daniel D Bennett, Ricardo V Lloyd
Merkel cell carcinoma (MCC) is a rare, clinically aggressive, cutaneous neuroendocrine (NE) neoplasm. As a tumor with small, round, blue cells, the histologic differential diagnosis for MCC can include melanoma, metastatic small cell carcinoma (SCC), nodular hematopoietic tumors, basal cell carcinoma (BCC), atypical variants of squamous carcinoma, and the uncommon occurrence of primary cutaneous Ewing sarcoma. In cases with atypical histology or without the classic immunophenotype the diagnosis can be challenging...
November 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29145324/a-rare-case-of-merkel-cell-carcinoma-presenting-as-a-giant-intra-thoracic-mass-a-case-report-and-review-of-the-literature
#17
Feng-Wei Kong, Miao Zhang, Heng Wang, Cun-Tao Lu, Wen-Bin Wu, Yuan-Yuan Liu
RATIONALE: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine-derived cutaneous cancer. Ectopic or single metastatic MCC located in thorax is extremely rare; meanwhile, its definite management has not been elucidated yet. PATIENT CONCERNS: A 64-year-old female patient with a giant mass located in her left thorax was presented for stuffy pain of left chest for 6 months and fever for half a month. She underwent radical resection of vulvar MCC 10 years ago...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142746/interaction-between-merkel-cell-carcinoma-and-the-immune-system-pathogenetic-and-therapeutic-implications
#18
Irene Zanetti, Ilaria Coati, Mauro Alaibac
Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine carcinoma. It usually appears on the face and neck of elderly Caucasian people as a flesh-colored, erythematous or violaceous dome-shaped, non-tender nodule with a smooth surface. In immunocompromised patients with T-cell dysfunction, such as patients with acquired immunodeficiency syndrome (AIDS) or solid organ transplant recipients, the incidence of this disease is markedly increased. This suggests a link between the development of MCC and the immune system...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29123950/immune-evasion-mechanisms-and-immune-checkpoint-inhibition-in-advanced-merkel-cell-carcinoma
#19
REVIEW
Dirk Schadendorf, Paul Nghiem, Shailender Bhatia, Axel Hauschild, Philippe Saiag, Lisa Mahnke, Subramanian Hariharan, Howard L Kaufman
Merkel cell carcinoma (MCC) is a rare skin cancer caused by Merkel cell polyomavirus (MCPyV) infection and/or ultraviolet radiation-induced somatic mutations. The presence of tumor-infiltrating lymphocytes is evidence that an active immune response to MCPyV and tumor-associated neoantigens occurs in some patients. However, inhibitory immune molecules, including programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1), within the MCC tumor microenvironment aid in tumor evasion of T-cell-mediated clearance...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29108698/familial-isolated-primary-hyperparathyroidism-associated-with-germline-gcm2-mutations-is-more-aggressive-and-has-lesser-rate-of-biochemical-cure
#20
Mustapha El Lakis, Pavel Nockel, Bin Guan, Sunita Agarwal, James Welch, William F Simonds, Stephen Marx, Yulong Li, Naris Nilubol, Dhaval Patel, Lily Yang, Roxanne Merkel, Electron Kebebew
BACKGROUND: Hereditary primary hyperparathyroidism may be syndromic or nonsyndromic (familial isolated hyperparathyroidism). Recently, germline activating mutations in the GCM2 gene were identified in a subset of familial isolated hyperparathyroidism. This study examined the clinical and biochemical characteristics and the treatment outcomes of GCM2 mutation-positive familial isolated hyperparathyroidism as compared to sporadic primary hyperparathyroidism. METHODS: We performed a retrospective analysis of clinical features, parathyroid pathology, and operative outcomes in 18 patients with GCM2 germline mutations and 457 patients with sporadic primary hyperparathyroidism...
November 3, 2017: Surgery
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