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Merkel carcinoma

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https://www.readbyqxmd.com/read/29453830/eosinophilic-polymorphic-and-pruritic-eruption-associated-with-radiotherapy-in-a-patient-with-primary-nodal-merkel-cell-carcinoma
#1
Wedad Abdelrahman, Lin Shum, Damian McManus, Maureen Y Walsh, Olivia Dolan
No abstract text is available yet for this article.
February 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29445030/cabozantinib-in-patients-with-advanced-merkel-cell-carcinoma
#2
Guilherme Rabinowits, Cecilia Lezcano, Paul J Catalano, Patricia McHugh, Hailey Becker, Megan M Reilly, Julian Huang, Ayushi Tyagi, Manisha Thakuria, Scott C Bresler, Lynette M Sholl, Geoffrey I Shapiro, Robert Haddad, James A DeCaprio
BACKGROUND: This study sought to determine the efficacy and safety profile of cabozantinib in patients with advanced Merkel cell carcinoma (MCC). EXPERIMENTAL DESIGN: This prospective, phase II, single-institution trial enrolled patients with platinum-failure, recurrent/metastatic MCC to receive cabozantinib 60 mg orally daily until disease progression, withdrawal from study, or severe toxicity. The primary endpoint was disease control rate. Secondary endpoints included overall survival (OS), progression-free survival (PFS), and toxicity...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29430700/a-monoclonal-antibody-to-sv40-large-t-antigen-pab416-does-not-label-merkel-cell-carcinoma
#3
Daniel J Pelletier, Thomas W Czeczok, Andrew M Bellizzi
AIMS: Merkel cell carcinoma represents poorly differentiated neuroendocrine carcinoma of cutaneous origin. In most studies the vast majority of Merkel cell carcinomas are Merkel cell polyomavirus (MCPyV)-associated. SV40 polyomavirus immunohistochemistry is typically used in the diagnosis other polyomavirus-associated diseases including tubulointerstitial nephritis and progressive multifocal leukoencephalopathy, given cross-reactivity with BK and JC polyomaviruses. MCPyV-specific immunohistochemistry is commercially available, but if SV40 immunohistochemistry also cross-reacted with MCPyV that would be advantageous from a resource-utilization perspective...
February 11, 2018: Histopathology
https://www.readbyqxmd.com/read/29422311/merkel-cell-carcinoma-in-a-steer
#4
A P P Teh, U Z Izzati, N V Diep, T Hirai, R Yamaguchi
Merkel cell carcinoma is a rare and aggressive cutaneous neuroendocrine tumour reported only in man, dogs and cats. A 20-month-old Japanese black fattening steer was presented with necrotic protruding skin masses over the left thoracic area and a 20 × 25 cm subcutaneous mass in the left abdominal area. Microscopical evaluation of the masses revealed cords of small to medium-sized round tumour cells with marked anisocytosis and anisokaryosis and clear and vacuolated cytoplasm, which were separated by a delicate fibrovascular stroma and arranged in a trabecular and nested pattern...
January 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29420353/clusterin-in-neuroendocrine-epithelial-neoplasms-absence-of-expression-in-a-well-differentiated-tumor-suggests-a-jejunoileal-origin
#5
Thomas W Czeczok, Kristen M Stashek, Jessica E Maxwell, Thomas M O'Dorisio, James R Howe, Jason L Hornick, Andrew M Bellizzi
Clusterin, a widely expressed, tissue-specific glycoprotein, is a diagnostic marker of several tumor types, including anaplastic large cell lymphoma, follicular dendritic cell sarcoma, and tenosynovial giant cell tumor. A recent study has suggested it is highly expressed by well-differentiated neuroendocrine tumors (NET) arising at most anatomic sites, with the exception of jejunoileal tumors, and that it is similarly not expressed by poorly differentiated neuroendocrine carcinomas (NEC). We sought to validate this result in a large cohort of NETs and NECs...
February 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29419589/merkel-cell-carcinoma-of-the-cheek
#6
Andrea Sisti, Cesare Brandi, Luca Grimaldi, Edoardo Pica Alfieri, Roberto Cuomo, Irene Zerini, Giuseppe Nisi
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with a neuroendocrine phenotype. Here, the authors reported a case of MCC, presented as a rapidly growing, asymptomatic, erythematous nodule measuring 3.8 cm × 2.8 cm in diameter on the right cheek of an 85-year-old Caucasian woman. After resection of the nodule, the defect was repaired with cutaneous graft taken from the supraclavicular area and healed uneventfully. Histopathologic examination confirmed the diagnosis of MCC.
February 6, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29409030/genetic-variability-of-the-noncoding-control-region-of-cutaneous-merkel-cell-polyomavirus-identification-of-geographically-related-genotypes
#7
Yumiko Hashida, Tomonori Higuchi, Kiyohiko Matsui, Yuka Shibata, Kimiko Nakajima, Shigetoshi Sano, Masanori Daibata
Background: Merkel cell polyomavirus (MCPyV) is a ubiquitous cutaneous virus that causes Merkel cell carcinoma (MCC), which develops preferentially in white European/North American populations. However, the genomic variations of MCPyV among ethnic groups have not been well delineated, and even less is known regarding alterations in the noncoding control region (NCCR) in the general population. Methods: MCPyV strains recovered from skin swabs of 250 healthy participants with distinct ethnicity/geographic origins were subjected to sequencing analysis of the NCCR...
February 2, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29408552/demographics-and-outcomes-of-stage-i-ii-merkel-cell-carcinoma-treated-with-mohs-micrographic-surgery-compared-with-wide-local-excision-in-the-national-cancer-data-base
#8
Babu Singh, Muhammad M Qureshi, Minh Tam Truong, Debjani Sahni
BACKGROUND: The optimal surgical approach (wide local excision (WLE) vs. Mohs micrographic surgery (MOHS)) for treating Merkel cell carcinoma (MCC) is yet to be determined. OBJECTIVE: To compare survival outcomes in patients with early stage MCC treated with MOHS versus WLE. METHODS: A retrospective review of all cases in the National Cancer Data Base (NCDB) of MCC of clinical Stage I-II MCC treated with WLE or MOHS was performed. RESULTS: 1,795 cases of Stage I-II MCC were identified who underwent WLE (N=1,685) or MOHS (N=110)...
February 3, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29408534/probability-of-positive-genetic-testing-results-in-patients-with-family-history-of-primary-hyperparathyroidism
#9
Mustapha El Lakis, Pavel Nockel, Apostolos Gaitanidis, Bin Guan, Sunita Agarwal, James Welch, William F Simonds, Lee Weinstein, Stephen Marx, Naris Nilubol, Dhaval Patel, Roxanne Merkel, Amit Tirosh, Electron Kebebew
BACKGROUND: Approximately 10% of patients with primary hyperparathyroidism (PHPT) have hereditary disease. Hereditary PHPT may be syndromic (multiple endocrine neoplasia (MEN1, 2, 4), hyperparathyroidism-jaw tumor syndrome) or non-syndromic (familial isolated primary hyperparathyroidism). There are limited data on the probability of testing positive for genetic mutation based on clinical presentation. The aim of this study was to determine potential associations between clinical and biochemical features and mutation in susceptibility genes for PHPT in patients with a family history of PHPT...
February 2, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29405630/prospective-analysis-of-the-utility-of-18-fdg-pet-in-merkel-cell-carcinoma-of-the-skin-a-trans-tasman-radiation-oncology-group-study-trog-09-03
#10
Michael Poulsen, David Macfarlane, Michael Veness, Venessa Estall, George Hruby, Mahesh Kumar, Andrew Pullar, Lee Tripcony, Danny Rischin
INTRODUCTION: TROG 09.03 prospectively studied the utility of Fluorine-18 Fluorodeoxyglucose (18-FDG) PET in the management of Merkel cell carcinoma of skin. METHODS: Following consent and registration, a pre-treatment FDG-PET/CT was performed. Sites of avid disease were confirmed by cytology where practicable. Following surgery, patients with AJCCv7 Stages IIA-IIIB disease were treated with chemo-radiotherapy and reassessed with a post-treatment PET. RESULTS: Fifty-eight subjects (45 males and 13 females, median age 68 years) were enrolled between 2011 and 2015, 43 patients of whom went on to receive chemo-radiotherapy...
February 5, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29379978/outcome-of-combined-treatment-of-surgery-and-adjuvant-radio-therapy-in-merkel-cell-carcinoma
#11
Eckhard Fiedler, Dirk Vordermark
In recent analyses of Merkel cell carcinoma, prognosis is poor even in stages I and II. We performed a monocentric retrospective study of 37 consecutive cases with Merkel cell carcinoma stage I to III treated with a combination of surgery and adjuvant radiation to evaluate progression-free and overall survival. The median primary tumor diameter was 17.9 mm. Cases consisted of 31 primary tumors, of which 13 had negative sentinel lymph node biopsy (IA n = 10 and IIA n = 3) and 18 no sentinel lymph node biopsy (IB n = 15 and IIB n = 3), 2 tumors with positive sentinel lymph node biopsy (IIIA) and 4 with local macrometastasis (IIIB)...
January 30, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29377285/retrospective-study-on-the-correlation-between-18-fluorodeoxyglucose-uptake-in-positron-emission-tomography-computer-tomography-and-tumor-volume-cytological-activity-as-assessed-with-ki-67-and-glut-1-staining-in-10-cases-of-merkel-cell-carcinoma
#12
S Kitamura, T Yanagi, Y Inamura-Takashima, K Imafuku, H Hata, J Uehara, Y Ishida, A Otsuka, K Hirata, H Shimizu
Merkel cell carcinoma (MCC) is a rare malignant neuro-endocrine tumor of the skin that shows aggressive behavior and has a high tendency for local recurrence and lymph node or distant metastasis.1 Recently, some reports have stated that 18-fluorodeoxyglucose positron emission tomography-computer tomography (FDG PET-CT) is more useful than conventional CT.2, 3 However, the utility of FDG PET-CT for determining the proliferative or metabolic activity of MCC is unclear. In this study, we investigated the correlation between FDG uptake and proliferative of metabolic activity as revealed by PET-CT imaging with Ki-67 immunological staining or GLUT-1 immunological staining in 10 cases of MCC...
January 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29348162/mutation-burden-predicts-anti-pd-1-response
#13
(no author information available yet)
A new study finds that objective response rates to anti-PD-1 therapies correlate with tumor mutation burden for most of the 27 cancer types studied. Objective response rates were higher than expected for Merkel cell carcinoma and renal cell carcinoma, which may be particularly immunogenic. The objective response rate was unexpectedly low for colorectal cancer with mismatch repair proficiency.
January 18, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29347993/updated-efficacy-of-avelumab-in-patients-with-previously-treated-metastatic-merkel-cell-carcinoma-after-%C3%A2-1-year-of-follow-up-javelin-merkel-200-a-phase-2-clinical-trial
#14
Howard L Kaufman, Jeffery S Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P D'Angelo, Kent C Shih, Céleste Lebbé, Michele Milella, Isaac Brownell, Karl D Lewis, Jochen H Lorch, Anja von Heydebreck, Meliessa Hennessy, Paul Nghiem
BACKGROUND: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with poor survival outcomes in patients with distant metastatic disease (mMCC). In an initial analysis from JAVELIN Merkel 200, a phase 2, prospective, open-label, single-arm trial in mMCC, avelumab-a human anti-programmed death-ligand 1 (PD-L1) monoclonal antibody-showed promising efficacy and a safety profile that was generally manageable and tolerable. Here, we report the efficacy of avelumab after ≥1 year of follow-up in patients with distant mMCC that had progressed following prior chemotherapy for metastatic disease...
January 19, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29341266/merkel-cell-carcinoma-in-france-a-registries-based-comprehensive-epidemiological-survey
#15
M Fondain, O Dereure, Z Uhry, A V Guizard, A S Woronoff, M Colonna, F Molinie, S Bara, M Velten, E Marrer, P Grosclaude, B Lapôtre-Ledoux, B Tretarre, B Guillot
BACKGROUND: Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma. Owing to its low incidence, epidemiological data are scarce and have never been analysed in France to identify the main epidemiological trends. METHODS: Data from MCC patients diagnosed between 1998 and 2010 were obtained from 11 French cancer registries in the FRANCIM network. The main epidemiological characteristics of MCC were investigated between 2006 and 2010 because comprehensive data were only available for this period...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29332376/new-and-emerging-treatments-for-metastatic-merkel-cell-carcinoma
#16
Giovanni Cestaro, Gennaro Quarto, Marco DE Monti, Fabrizio Fasolini, Marco DE Fazio, Ermenegildo Furino, Maurizio Gentile
No abstract text is available yet for this article.
January 11, 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29324933/brachytherapy-in-soft-tissue-tumours-an-interdisciplinary-challenge
#17
Silvanie Volz, Konstantinos Kalousis, Jung In Song, Tobias Kisch, Eike Wenzel, Peter Mailänder
OBJECTIVE: Interdisciplinary work including surgery and additive radiotherapy is often needed for the therapy of tumours. Beneath this, brachytherapy is an important part of the radiotherapy. It was first used over 100 years ago and is in regular use after the development of afterload technology in the early 1970s. Today it is often used in different tumour therapies, for example in soft tissue sarcoma or breast tumours, in order to decrease the risk of local recurrence. Concerning its benefits, higher doses could be used because of the localized effect with equivalent local control rate and less toxicity of treatment...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29321666/are-there-multiple-cells-of-origin-of-merkel-cell-carcinoma
#18
REVIEW
J C Sunshine, N S Jahchan, J Sage, J Choi
Merkel cell carcinoma (MCC) is a rare but lethal cancer with the highest case-by-case fatality rate among all skin cancers. Eighty percent of cancers are associated with the Merkel cell polyomavirus (MCPyV). Twenty percent of MCCs are virus negative. Recent epidemiological data suggest that there are important, clinically relevant differences between these two subtypes of MCC. Recent studies in cancer genomics, mouse genetics, and virology experiments have transformed our understanding of MCC pathophysiology...
January 11, 2018: Oncogene
https://www.readbyqxmd.com/read/29314048/adjuvant-radiation-therapy-improves-patient-survival-in-early-stage-merkel-cell-carcinoma-a-15-year-single-institution-study
#19
Albert Y Han, Pratik B Patel, Mitchell Anderson, Miguel F P Diaz, Robert Chin, Maie A St John
OBJECTIVES/HYPOTHESIS: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine neoplasm of the skin. Growing evidence supports the benefit of postoperative adjuvant radiation therapy (RT) for locoregional control, but whether it improves overall survival (OS) has been debated. Our objective was to compare the OS of MCC patients who received postoperative RT with those who received surgery alone. STUDY DESIGN: Retrospective case series. METHODS: Cases of MCC between 2001 and 2016 at the University of California, Los Angeles Health System were reviewed...
January 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29313804/endolymphatic-balloon-occluded-retrograde-abdominal-lymphangiography-boral-and-embolization-borale-for-the-diagnosis-and-treatment-of-chylous-ascites-technique-and-experience-in-three-patients
#20
Ravi N Srinivasa, Joseph J Gemmete, Matthew L Osher, Jeffrey Forris Beecham Chick
PURPOSE: To describe endolymphatic balloon-occluded retrograde abdominal lymphangiography (BORAL) and embolization (BORALE) for diagnosis and treatment of chylous ascites in patients with previously unidentifiable leakage site or failed lymphatic embolization. MATERIALS AND METHODS: Two (66%) men and one (33%) woman with mean age of 52 years (range: range: 14-79 years) presented with chylous ascites and underwent BORAL or BORALE between March 2016 and February 2017...
December 4, 2017: Annals of Vascular Surgery
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