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https://www.readbyqxmd.com/read/29905548/cutaneous-polypoid-melanoma-of-head-and-neck
#1
U Wollina, G Hansel, J Schönlebe
Cutaneous polypoid melanoma is an uncommon subtype of malignant melanoma. The clinical behavior of this subtype has been described as aggressive. Tumors can be sessile or pedunculated. The typical patient is a younger adult. Authors have analyzed the case histories of patients with polypoid melanomas of the head and neck region treated at our clinic from 2001 to 2018. We identified 3 female patients with tumors of the neck and cheek. In contrast to other reports, all patients were older than 80-years of age...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29894357/primary-visceral-merkel-cell-carcinoma-a-case-report-and-review-of-the-literature
#2
Andrew Siref, Bonnie Balzer, Andrew Hendifar
A 63-year-old white man with no significant previous medical or surgical history presented with painless jaundice after 3 weeks of dark urine, yellow stools, and a 9-pound weight loss. Bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase were elevated, and a computed tomography scan detected a 10-cm, ill-defined mass at the porta hepatis compressing the common bile duct. He underwent endoscopic retrograde cholangiopancreatography with stenting and ultrasound-guided biopsies. Histologic sections showed a neoplastic population of small ovoid cells with a high N:C ratio, nuclear hyperchromasia, "smoky" chromatin and abundant mitotic figures, and characteristic of high-grade neuroendocrine carcinoma (HGNECA)...
June 7, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29891528/advances-in-immunotherapy-for-metastatic-merkel-cell-carcinoma-a-clinician-s-guide
#3
REVIEW
Kelly G Paulson, Shailender Bhatia
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer. The clinical impact of MCC has been increasing due to steadily rising incidence rates. Since 2001, more than 24,000 cases of MCC have been reported to the US National Program of Cancer Registries database, and in 2018, more than 2,500 incident cases are expected. MCC is highly aggressive, and one-third of patients will either present with or develop metastatic disease. Outcomes in patients with metastatic MCC have historically been poor; median time to progression with cytotoxic chemotherapy is only 3 months...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29891527/radiotherapy-in-the-multidisciplinary-management-of-merkel-cell-carcinoma
#4
REVIEW
Michael D Green, James A Hayman
The management of Merkel cell carcinoma (MCC) requires multidisciplinary care for optimal patient outcomes. Radiotherapy (RT) is most commonly used as adjuvant therapy to improve locoregional control in patients with MCC who undergo surgery. Additionally, it can sometimes be used as definitive monotherapy for patients who decline or are not candidates for surgery and as palliative treatment in those with metastatic MCC. This article discusses the indications, treatment considerations, and recommended dose prescriptions for RT in the management of early- and advanced-stage disease...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29891526/merkel-cell-carcinoma-version-1-2018-nccn-clinical-practice-guidelines-in-oncology
#5
Christopher K Bichakjian, Thomas Olencki, Sumaira Z Aasi, Murad Alam, James S Andersen, Rachel Blitzblau, Glen M Bowen, Carlo M Contreras, Gregory A Daniels, Roy Decker, Jeffrey M Farma, Kris Fisher, Brian Gastman, Karthik Ghosh, Roy C Grekin, Kenneth Grossman, Alan L Ho, Karl D Lewis, Manisha Loss, Daniel D Lydiatt, Jane Messina, Kishwer S Nehal, Paul Nghiem, Igor Puzanov, Chrysalyne D Schmults, Ashok R Shaha, Valencia Thomas, Yaohui G Xu, John A Zic, Karin G Hoffmann, Anita M Engh
This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on areas impacted by recently emerging data, including sections describing MCC risk factors, diagnosis, workup, follow-up, and management of advanced disease with radiation and systemic therapy. Included in these sections are discussion of the new recommendations for use of Merkel cell polyomavirus as a biomarker and new recommendations for use of checkpoint immunotherapies to treat metastatic or unresectable disease. The next update of the complete version of the NCCN Guidelines for MCC will include more detailed information about elements of pathology and addresses additional aspects of management of MCC, including surgical management of the primary tumor and draining nodal basin, radiation therapy as primary treatment, and management of recurrence...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29888815/merkel-cell-polyomavirus-integration-pcr-in-bilateral-metachronous-merkel-cell-carcinoma-on-the-nose
#6
Susanne Hanner, Ulrike Wieland, Wolfgang Hartschuh, Alexander Enk, Ferdinand Toberer
An 81-year-old woman presented with a several weeks history of an erythematous tumour at her right nostril (Figure 1a). The tumour was surgically removed. Histopathology showed peritumoral clefts and BerEP4-expression consistent with basal cell carcinoma (Figure 2a). One year later the patient developed a small erythematous tumour at the left nostril (Figure 1b). Histopathology was consistent with a diagnosis of Merkel cell carcinoma (MCC) (Figure 2c,d). The tumour was removed using Mohs micrographic surgery...
June 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29881592/merkel-cell-carcinoma-with-intramedullary-spinal-cord-metastasis-a-very-rare-clinical-finding
#7
Tarek Haykal, Basim Towfiq
This clinical image teaches readers that a rare finding such as intramedullary spinal metastasis could exist even in the rarest tumors. It adds to the literature how it was managed. It also might reflect the improvement of our cancer treatment allowing us to follow patients longer to find those rare findings in rare tumors.
June 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29877957/change-in-eyelid-carcinoma-t-category-with-use-of-the-8th-versus-7th-edition-of-the-american-joint-committee-on-cancer-cancer-staging-manual
#8
Stephanie Ding, Oded Sagiv, Yunxia Guo, Thomas J Kandl, Sudip D Thakar, Bita Esmaeli
PURPOSE: To evaluate the frequency and nature of changes in T category when eyelid carcinomas are staged using the criteria in the 8th edition instead of the 7th edition of the American Joint Committee on Cancer staging manual. METHODS: Following Institutional Review Board approval, a retrospective review was conducted for all consecutive patients with the diagnosis of eyelid carcinoma treated by the senior author from January 2012 through December 2016. After a review of the clinical and pathologic data, each patient's disease was staged using both the 7th-edition and 8th-edition American Joint Committee on Cancer criteria for eyelid carcinomas...
June 5, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29865947/merkel-cell-carcinoma-in-a-patient-with-cll-atypical-aml
#9
Shari R Lipner
No abstract text is available yet for this article.
May 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29864470/influence-of-age-and-marital-status-on-stage-at-diagnosis-and-survival-of-patients-with-merkel-cell-carcinoma-a-seer-based-cohort-study
#10
Michael A Liu, Jannett Nguyen, Jane A Driver
No abstract text is available yet for this article.
June 1, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29857880/a-21-year-course-of-merkel-cell-carcinoma-with-adjuvant-viscum-album-extract-treatment-a-case-report
#11
Paul G Werthmann, Lothar Kindermann, Gunver S Kienle
BACKGROUND: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating effects. CASE PRESENTATION: A 64-year-old woman was diagnosed with a MCC of the left forearm. In the following course of 21 years, she experienced 4 episodes of lymph node relapse (axillary, submandibular, axillary, clavicular)...
June 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29848371/in-field-and-abscopal-response-after-short-course-radiation-therapy-in-patients-with-metastatic-merkel-cell-carcinoma-progressing-on-pd-1-checkpoint-blockade-a-case-series
#12
Melody J Xu, Susan Wu, Adil I Daud, Siegrid S Yu, Sue S Yom
BACKGROUND: Patients with metastatic Merkel cell carcinoma (mMCC) who experience disease progression on immunotherapy have limited additional standard options. Given evidence of synergism between radiation therapy (RT) and immunotherapy, two patients progressing on PD-1 inhibition were referred for short-course RT. CASE PRESENTATION: Two patients were found to have progressive mMCC on PD-1 inhibitor therapy and were treated with single-fraction palliative RT. Both patients were observed to have local control at irradiated regions, as well as durable abscopal response at unirradiated, out-of-field, sites of metastatic disease...
May 30, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29808366/merkel-cell-carcinoma-and-cellular-cytotoxicity-sensitivity-to-cellular-lysis-and-screening-for-potential-target-antigens-suitable-for-antibody-dependent-cellular-cytotoxicity
#13
Jocelyn Ollier, Thibault Kervarrec, Mahtab Samimi, Houssem Benlalam, Pascal Aumont, Régine Vivien, Antoine Touzé, Nathalie Labarrière, Henri Vié, Béatrice Clémenceau
The recent success of checkpoint inhibitors in the treatment of Merkel cell carcinoma (MCC) confirms that MCC tumors can be immunogenic. However, no treatment directly targeting the tumor is available for use in combination with these checkpoint inhibitors to enhance their efficacity. This study was carried out to characterize MCC line sensitivity to cellular lysis and to identify cell surface antigens that could be used for direct targeting of this tumor. For five representative MCC lines, the absence or low expression of MICA, MICB, HLA-I, and ICAM-1 was associated with low level of recognition by NK cells and T lymphocytes...
May 28, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29799096/avelumab-a-review-in-metastatic-merkel-cell-carcinoma
#14
REVIEW
Matt Shirley
Avelumab (Bavencio® ) is a fully human IgG1 monoclonal antibody that is directed against programmed cell death ligand 1 (PD-L1). Avelumab functions as an immune checkpoint inhibitor and has recently been approved in the USA, the EU and Japan for the treatment of metastatic Merkel cell carcinoma (MCC). It is thus the first therapeutic agent specifically approved for use in this indication, and is approved for use independent of line of treatment. Approval for avelumab in metastatic MCC was based on the two-part, single-arm, phase II trial, JAVELIN Merkel 200...
May 24, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29794506/merkel-cell-carcinoma-of-the-wrist-a-case-report
#15
Hyung Jun Min, Ji Hun Kim, Yang Woo Kim, Young Woo Cheon
PURPOSE: Merkel cell carcinomas are a rare type of neuroendocrine tumors of the head, neck, and extremities commonly found in older patients. Merkel cell carcinomas present as red-to-purple and nontender nodules with or without surface ulceration, usually measuring 2 cm in diameter. CASE PRESENTATIONS: An 83-year-old woman with a skin-colored nodule on the dorsal aspect of her right wrist was referred to our department for treatment. The regional lymph nodes were not palpable, and the positron emission tomography/computed tomography scan did not reveal any distant metastases...
May 23, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29790179/merkel-cell-carcinoma-clinical-outcome-and-prognostic-factors-in-351-patients
#16
Linde M van Veenendaal, Alexander C J van Akkooi, Cees Verhoef, Dirk Jan Grünhagen, W Martin C Klop, Gerlof D Valk, Margot E T Tesselaar
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma of the skin. AIM: To describe clinical outcome and prognostic factors of MCC patients in two expert-centers. METHOD: Patients with histologically confirmed MCC in 1990-2014 were included. Data on patient, tumor characteristics and treatment were retrospectively collected. RESULTS: A total of 351 Patients were evaluated, 153 (44%) males, median age 74 years (range 28-94)...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29785334/radiotherapy-for-inoperable-merkel-cell-carcinoma-a-systematic-review-and-pooled-analysis
#17
Parth Patel, Chirag Modi, Beth McLellan, Nitin Ohri
Background: Cumulative data on radiation monotherapy for Merkel cell carcinoma (MCC) is lacking. Objective: We sought to synthesize all available data on treatment outcomes for radiation monotherapy for inoperable stage I-III MCC. Methods: We performed a systematic review of the current literature. Articles published in English in the PubMed database up to July 29, 2016, were evaluated. Results: Eight case reports, 4 case series, and 6 retrospective studies, yielding 68 patients, were included in our analysis...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29780576/merkel-cell-carcinoma-extended-lymphadenectomy-and-reconstruction-with-biosynthetic-prosthesis
#18
Enrico Coppola Bottazzi, Adele Noviello, Nicola Moles, Antonio Miro, Augusto Striano, Mario Baiamonte, Francesco Esposito, Francesco Crafa
Introduction: Merkel cell carcinomas (MCC) is an aggressive neuroendocrine carcinoma originating from the Merkel cell in the dermo-epidermal junction. Only 10% of MCC occur on the skin of the trunk. Case report: We report a case of Merkel's abdominal carcinomas treated with extensive inguinal lymphadenectomy and reconstruction of the abdominal wall and inguinal canal using prosthesis GORE® BIO-A® . Discussion: Immunohistochemical analysis by tumor-specific markers is crucial for diagnosis and permits differentiation from other tumors of the skin...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29777657/mcv-mir-m1-targets-the-host-cell-immune-response-resulting-in-the-attenuation-of-neutrophil-chemotaxis
#19
P Akhbari, D Tobin, K Poterlowicz, W Roberts, J R Boyne
Virus-encoded miRNAs are emerging as key regulators of persistent infection and host-cell immune evasion. Merkel cell polyomavirus (MCPyV), the predominant aetiological agent of Merkel cell carcinoma (MCC), encodes a single miRNA, MCV-miR-M1, which targets the oncogenic MCPyV large T antigen (LT). MCV-miR-M1 has previously been shown to play an important role in establishment of long-term infection, however, the underlying mechanism is not fully understood. A key unanswered question is whether, in addition to auto-regulating LT, MCV-miR-M1 also targets cellular transcripts to orchestrate an environment conducive for persistent infection...
May 16, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29763480/spontaneous-regression-of-merkel-cell-carcinoma
#20
Sean Branch, Kenneth Maloney, Stephen M Purcell
A 96-year-old woman presented with a rapidly enlarging lesion overlying the suprasternal notch. The lesion originated as a small, erythematous, scaly macule that rapidly increased in size over 8 weeks and became an ulcerated nodule measuring 5 cm in diameter and 4.5 cm in thickness. A 4-mm punch biopsy showed a poorly differentiated tumor with cells that were positive for CAM 5.2 and cytokeratin 20 in a dotlike paranuclear pattern and negative for cytokeratin 5/6, human melanoma black 45, and leukocyte common antigen...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
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