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Roy Adaptation Model

Dieter Hackenberg, Michael R McKain, Soon Goo Lee, Swarup Roy Choudhury, Tyler McCann, Spencer Schreier, Alex Harkess, J Chris Pires, Gane Ka-Shu Wong, Joseph M Jez, Elizabeth A Kellogg, Sona Pandey
Signaling pathways regulated by heterotrimeric G-proteins exist in all eukaryotes. The regulator of G-protein signaling (RGS) proteins are key interactors and critical modulators of the Gα protein of the heterotrimer. However, while G-proteins are widespread in plants, RGS proteins have been reported to be missing from the entire monocot lineage, with two exceptions. A single amino acid substitution-based adaptive coevolution of the Gα:RGS proteins was proposed to enable the loss of RGS in monocots. We used a combination of evolutionary and biochemical analyses and homology modeling of the Gα and RGS proteins to address their expansion and its potential effects on the G-protein cycle in plants...
September 16, 2016: New Phytologist
Sébastien A B Roy, Joannie M Allaire, Camille Ouellet, Faiza Maloum-Rami, Véronique Pomerleau, Étienne Lemieux, Jean-Philippe Babeu, Jasmin Rousseau, Marilène Paquet, Perrine Garde-Granger, François Boudreau, Nathalie Perreault
Bmps are morphogens involved in various gastric cellular functions. Studies in genetically-modified mice have shown that Bmp disruption in gastric epithelial and stromal cell compartments leads to the development of tumorigenesis. Our studies have demonstrated that abrogation of gastric epithelial Bmp signaling alone was not sufficient to recapitulate the neoplastic features associated with total gastric loss of Bmp signaling. Thus, epithelial Bmp signaling does not appear to be a key player in gastric tumorigenesis initiation...
2016: Scientific Reports
Émilie Lecompte, Mohand-Ameziane Bouanani, Alexandra Magro, Brigitte Crouau-Roy
Population genetics and phenotypic structures are often predicted to vary along the geographic range of a species. This phenomenon would be accentuated for species with large range areas, with discontinuities and marginal populations. We herein compare the genetic patterns of central populations of Coccinella septempunctata L. with those of two phenotypically differentiated populations considered as rear-edge populations and subspecies based on phenotype (Algeria and Japan). According to the central-marginal model and expected characteristics of rear-edge populations, we hypothesize that these rear-edge populations have (1) a reduced genetic diversity, resulting from their relative isolation over long periods of time, (2) a higher population genetic differentiation, explained by low contemporary gene flow levels, and (3) a relationship between genetic diversity characteristics and phenotypes, due to historical isolation and/or local adaptation...
August 2016: Ecology and Evolution
Richard P Shefferson, Mélanie Roy, Ülle Püttsepp, Marc-André Selosse
Evolutionary losses of photosynthesis in terrestrial plants all originate in photosynthetic ancestors. The adaptive context under which this transition happens has remained elusive because of the rarity of plants in which both photosynthetic and non-photosynthetic forms exist as a polymorphism. Here, we report on demographic patterns in photosynthetic ("green") and nonphotosynthetic ("albino") individuals within populations of two such species, Cephalanthera damasonium and C. longifolia, which also acquire nutrition from their mycorrhizal hosts (partial mycoheterotrophy)...
June 2016: Ecology
Gitashri Naiya, Paromita Raha, Manas Kumar Mondal, Uttam Pal, Rajesh Saha, Susobhan Chaudhuri, Subrata Batabyal, Samir Kumar Pal, Dhananjay Bhattacharyya, Nakul C Maiti, Siddhartha Roy
Recognition of multiple functional DNA sequences by a DNA-binding protein occurs widely in nature. The physico-chemical basis of this phenomenon is not well-understood. The E. coli gal repressor, a gene regulatory protein, binds two homologous but non-identical sixteen basepair sequences in the gal operon and interacts by protein-protein interaction to regulate gene expression. The two sites have nearly equal affinities for the Gal repressor. Spectroscopic studies of the Gal repressor bound to these two different DNA sequences detected significant conformational differences between them...
August 21, 2016: Physical Chemistry Chemical Physics: PCCP
Somnath Roy, B C Marndi, B Mawkhlieng, A Banerjee, R M Yadav, A K Misra, K C Bansal
BACKGROUND: Hill rices (Oryza sativa L.) are direct seeded rices grown on hill slopes of different gradients. These landraces have evolved under rainfed and harsh environmental conditions and may possess genes governing adaptation traits such as tolerance to cold and moisture stress. In this study, 64 hill rice landraces were collected from the state of Arunachal Pradesh of North-Eastern region of India, and assessed by agro-morphological variability and microsatellite markers polymorphism...
2016: BMC Genetics
Kaitlyn N Lewis, Ilya Soifer, Eugene Melamud, Margaret Roy, R Scott McIsaac, Matthew Hibbs, Rochelle Buffenstein
Animals have evolved to survive, and even thrive, in different environments. Genetic adaptations may have indirectly created phenotypes that also resulted in a longer lifespan. One example of this phenomenon is the preternaturally long-lived naked mole-rat. This strictly subterranean rodent tolerates hypoxia, hypercapnia, and soil-based toxins. Naked mole-rats also exhibit pronounced resistance to cancer and an attenuated decline of many physiological characteristics that often decline as mammals age. Elucidating mechanisms that give rise to their unique phenotypes will lead to better understanding of subterranean ecophysiology and biology of aging...
August 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
Ayse Kacaroglu Vicdan, Bilgi Gulseven Karabacak
BACKGROUND: The Roy Adaptation Model examines the individual in 4 fields: physiological mode, self-concept mode, role function mode, and interdependence mode. Hemodialysis treatment is associated with the Roy Adaptation Model as it involves fields that might be needed by the individual with chronic renal disease. PURPOSE: This research was conducted as randomized controlled experiment with the aim of determining the effect of the education given in accordance with the Roy Adaptation Model on physiological, psychological, and social adaptation of individuals undergoing hemodialysis treatment...
July 2016: Clinical Nurse Specialist CNS
John A Reid, Peter A Mollica, Garett D Johnson, Roy C Ogle, Robert D Bruno, Patrick C Sachs
The precision and repeatability offered by computer-aided design and computer-numerically controlled techniques in biofabrication processes is quickly becoming an industry standard. However, many hurdles still exist before these techniques can be used in research laboratories for cellular and molecular biology applications. Extrusion-based bioprinting systems have been characterized by high development costs, injector clogging, difficulty achieving small cell number deposits, decreased cell viability, and altered cell function post-printing...
June 2016: Biofabrication
Susan DeSanto-Madeya, Jacqueline Fawcett
Healing and transcendence are concepts of considerable interest to nurses who engage in holistic nursing practice. The two concepts are often used within the context of adaptation to describe the processes experienced by individuals who experience suffering and distress from various life events. Despite their intuitive significance to the human experience, the similarities and differences between the two concepts remains unclear. The purpose of this paper is to present the results of a Roy adaptation model-guided comparison of the two concepts that addresses their shared and distinct characteristics...
July 2016: Nursing Science Quarterly
Danny Vining, Jennifer C Robinson
Schizophrenia has a significant risk of damaging an individual's self-concept. Through the process of illness engulfment an individual's self-concept becomes reorganized entirely around the experience of having schizophrenia. The purpose of this manuscript is to clarify the structure and function of the concept of illness engulfment in schizophrenia using Walker and Avant's (2011) method of concept analysis. Data came from a review of scholarly literature, as well as contemporary and historical art, literature, music, and other media forms...
June 2016: Archives of Psychiatric Nursing
Lei Nie, Eric H Rubin, Nitin Mehrotra, José Pinheiro, Laura L Fernandes, Amit Roy, Stuart Bailey, Dinesh P de Alwis
Selection of the maximum tolerated dose (MTD) as the recommended dose for registration trials based on a dose-escalation trial using variations of an MTD/3 + 3 design often occurs in the development of oncology products. The MTD/3 + 3 approach is not optimal and may result in recommended doses that are unacceptably toxic for many patients and in dose reduction/interruptions that might have an impact on effectiveness. Instead of the MTD/3 + 3 approach, the authors recommend an integrated approach. In this approach, typically an adaptive/Bayesian model provides a general framework to incorporate and make decisions for dose escalation based on nonclinical data, such as animal efficacy and toxicity data; clinical data, including pharmacokinetics/pharmacodynamics data; and dose/exposure-response data for efficacy and safety...
June 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Goutam Chandra, Suresh B Rangasamy, Avik Roy, Jeffrey H Kordower, Kalipada Pahan
Parkinson disease (PD) is second only to Alzheimer disease as the most common human neurodegenerative disorder. Despite intense investigation, no interdictive therapy is available for PD. Recent studies indicate that both innate and adaptive immune processes are active in PD. Accordingly, we found a rapid increase in RANTES (regulated on activation normal T cell expressed and secreted) and eotaxin, chemokines that are involved in T cell trafficking, in vivo in the substantia nigra pars compacta and the serum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice...
July 15, 2016: Journal of Biological Chemistry
Zahra Farsi, Somayeh Azarmi
BACKGROUND: Any defect in the extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on coping strategies of the veterans with lower extremities amputation. METHODS: In a double-blind randomized controlled clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of Veterans Clinic in Tehran, Iran were recruited using convenience method and randomly assigned to intervention and control groups in 2013-2014...
April 2016: International Journal of Community Based Nursing and Midwifery
Denise Bockwoldt, Beth A Staffileno, Lola Coke, Rebekah Hamilton, Lou Fogg, Donna Calvin, Lauretta Quinn
African American (AA) adults are disproportionally affected by type 2 diabetes and are diagnosed at an earlier age, but are less adherent to diabetes medications compared with the general population. This qualitative study sought to describe the experiences of taking diabetes medications among midlife AA men and women with type 2 diabetes and to identify factors that influence these experiences. Fifteen AAs completed semistructured interviews. Using the Roy adaptation model, thematic analysis coded for both adaptive and ineffective experiences...
May 23, 2016: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
Lauren M Sippel, Alicia M Roy, Steven M Southwick, Harlan M Fichtenholtz
Theories of posttraumatic stress disorder (PTSD) implicate emotional processes, including difficulties utilizing adaptive emotion regulation strategies, as critical to the etiology and maintenance of PTSD. Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn (OIF/OEF/OND) veterans report high levels of combat exposure and PTSD. We aimed to extend findings suggesting that emotion regulation difficulties are a function of PTSD, rather than combat trauma exposure or common comorbidities, to OIF/OEF/OND veterans, in order to inform models of PTSD risk and recovery that can be applied to returning veterans...
September 2016: Cognitive Behaviour Therapy
Shumita Roy, Carolyn E Schwartz, Paul Duberstein, Michael G Dwyer, Robert Zivadinov, Niels Bergsland, Victoria Powell, Bianca Weinstock-Guttman, Ralph H B Benedict
OBJECTIVES: Cognitive reserve moderates the effects of gray matter (GM) atrophy on cognitive function in neurological disease. Broadly speaking, Reserve explains how persons maintain function in the face of cerebral injury in cognitive and other functional domains (e.g., physical, social). Personality, as operationalized by the Five Factor Model (FFM), is also implicated as a moderator of this relationship. It is conceivable that these protective mechanisms are related. Prior studies suggest links between Reserve and personality, but the degree to which these constructs overlap and buffer the clinical effects of neuropathology is unclear...
May 6, 2016: Journal of the International Neuropsychological Society: JINS
Marc Possmayer, Rajesh K Gupta, Beth Szyszka-Mroz, Denis P Maxwell, Marc-André Lachance, Norman P A Hüner, David Roy Smith
The Antarctic psychrophilic green alga Chlamy-domonas sp. UWO 241 is an emerging model for studying microbial adaptation to polar environments. However, little is known about its evolutionary history and its phylogenetic relationship with other chlamydomonadalean algae is equivocal. Here, we attempt to clarify the phylogenetic position of UWO 241, specifically with respect to Chlamydomonas rau-densis SAG 49.72. Contrary to a previous report, we show that UWO 241 is a distinct species from SAG 49.72. Our phylogenetic analyses of nuclear and plastid DNA sequences reveal that UWO 241 represents a unique lineage within the Moewusinia clade (sensu Nakada) of the Chlamydomonadales (Chlorophyceae, Chlorophyta), closely affiliated to the marine species Chlamydomonas parkeae SAG 24...
April 2016: Journal of Phycology
Sailesh Conjeti, Amin Katouzian, Abhijit Guha Roy, Loïc Peter, Debdoot Sheet, Stéphane Carlier, Andrew Laine, Nassir Navab
In this paper, we propose a supervised domain adaptation (DA) framework for adapting decision forests in the presence of distribution shift between training (source) and testing (target) domains, given few labeled examples. We introduce a novel method for DA through an error-correcting hierarchical transfer relaxation scheme with domain alignment, feature normalization, and leaf posterior reweighting to correct for the distribution shift between the domains. For the first time we apply DA to the challenging problem of extending in vitro trained forests (source domain) for in vivo applications (target domain)...
August 2016: Medical Image Analysis
Prasanta Roy, Binoy Krishna Roy
The Quadruple Tank Process (QTP) is a well-known benchmark of a nonlinear coupled complex MIMO process having both minimum and nonminimum phase characteristics. This paper presents a novel self tuning type Dual Mode Adaptive Fractional Order PI controller along with an Adaptive Feedforward controller for the QTP. The controllers are designed based on a novel Variable Parameter Transfer Function model. The effectiveness of the proposed model and controllers is tested through numerical simulation and experimentation...
July 2016: ISA Transactions
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