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Roy Adaptation Model

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https://www.readbyqxmd.com/read/27924919/a-central-cavity-within-the-holo-translocon-suggests-a-mechanism-for-membrane-protein-insertion
#1
Mathieu Botte, Nathan R Zaccai, Jelger Lycklama À Nijeholt, Remy Martin, Kèvin Knoops, Gabor Papai, Juan Zou, Aurélien Deniaud, Manikandan Karuppasamy, Qiyang Jiang, Abhishek Singha Roy, Klaus Schulten, Patrick Schultz, Juri Rappsilber, Giuseppe Zaccai, Imre Berger, Ian Collinson, Christiane Schaffitzel
The conserved SecYEG protein-conducting channel and the accessory proteins SecDF-YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion and membrane-protein insertion. By employing an integrative approach combining small-angle neutron scattering (SANS), low-resolution electron microscopy and biophysical analyses we determined the arrangement of the proteins and lipids within the super-complex. The results guided the placement of X-ray structures of individual HTL components and allowed the proposal of a model of the functional translocon...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916683/factor-analyses-for-the-%C3%A3-rebro-musculoskeletal-pain-questionnaire-for-working-and-non-working-patients-with-chronic-low-back-pain
#2
Remko Soer, Patrick Vroomen, Roy Stewart, Maarten Coppes, Patrick Stegeman, Pieter Dijkstra, Michiel Reneman
BACKGROUND CONTEXT: The ÖMPQ has good psychometric properties to predict return to work in patients with acute low back pain. Although it is used in patients with chronic back pain and non-workers, there is no evidence on the factor structure of the ÖMPQ in these populations. This is deemed an important prerequisite for future prediction studies. PURPOSE: to analyze the factor structure of the Örebro Musculoskeletal Pain Questionnaire (ÖMPQ) in working and non-working patients with chronic back pain...
December 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27910837/accurate-and-efficient-representation-of-intramolecular-energy-in-ab-initio-generation-of-crystal-structures-i-adaptive-local-approximate-models
#3
Isaac Sugden, Claire S Adjiman, Constantinos C Pantelides
The global search stage of crystal structure prediction (CSP) methods requires a fine balance between accuracy and computational cost, particularly for the study of large flexible molecules. A major improvement in the accuracy and cost of the intramolecular energy function used in the CrystalPredictor II [Habgood et al. (2015). J. Chem. Theory Comput. 11, 1957-1969] program is presented, where the most efficient use of computational effort is ensured via the use of adaptive local approximate model (LAM) placement...
December 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/27891651/developing-a-bayesian-adaptive-design-for-a-phase-i-clinical-trial-a-case-study-for-a-novel-hiv-treatment
#4
Alexina J Mason, Juan Gonzalez-Maffe, Killian Quinn, Nicki Doyle, Ken Legg, Peter Norsworthy, Roy Trevelion, Alan Winston, Deborah Ashby
The design of phase I studies is often challenging, because of limited evidence to inform study protocols. Adaptive designs are now well established in cancer but much less so in other clinical areas. A phase I study to assess the safety, pharmacokinetic profile and antiretroviral efficacy of C34-PEG4 -Chol, a novel peptide fusion inhibitor for the treatment of HIV infection, has been set up with Medical Research Council funding. During the study workup, Bayesian adaptive designs based on the continual reassessment method were compared with a more standard rule-based design, with the aim of choosing a design that would maximise the scientific information gained from the study...
November 27, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27825301/analysis-of-the-association-between-codon-optimality-and-mrna-stability-in-schizosaccharomyces-pombe
#5
Yuriko Harigaya, Roy Parker
BACKGROUND: Recent experiments have shown that codon optimality is a major determinant of mRNA stability in Saccharomyces cerevisiae and that this phenomenon may be conserved in Escherichia coli and some metazoans, although work in Neurospora crassa is not consistent with this model. RESULTS: We examined the association between codon optimality and mRNA stability in the fission yeast Schizosaccharomyces pombe. Our analysis revealed the following points. First, we observe a genome-wide association between codon optimality and mRNA stability also in S...
November 8, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27634188/g%C3%AE-and-regulator-of-g-protein-signaling-rgs-protein-pairs-maintain-functional-compatibility-and-conserved-interaction-interfaces-throughout-evolution-despite-frequent-loss-of-rgs-proteins-in-plants
#6
Dieter Hackenberg, Michael R McKain, Soon Goo Lee, Swarup Roy Choudhury, Tyler McCann, Spencer Schreier, Alex Harkess, J Chris Pires, Gane Ka-Shu Wong, Joseph M Jez, Elizabeth A Kellogg, Sona Pandey
Signaling pathways regulated by heterotrimeric G-proteins exist in all eukaryotes. The regulator of G-protein signaling (RGS) proteins are key interactors and critical modulators of the Gα protein of the heterotrimer. However, while G-proteins are widespread in plants, RGS proteins have been reported to be missing from the entire monocot lineage, with two exceptions. A single amino acid substitution-based adaptive coevolution of the Gα:RGS proteins was proposed to enable the loss of RGS in monocots. We used a combination of evolutionary and biochemical analyses and homology modeling of the Gα and RGS proteins to address their expansion and its potential effects on the G-protein cycle in plants...
September 16, 2016: New Phytologist
https://www.readbyqxmd.com/read/27609464/loss-of-mesenchymal-bone-morphogenetic-protein-signaling-leads-to-development-of-reactive-stroma-and-initiation-of-the-gastric-neoplastic-cascade
#7
Sébastien A B Roy, Joannie M Allaire, Camille Ouellet, Faiza Maloum-Rami, Véronique Pomerleau, Étienne Lemieux, Jean-Philippe Babeu, Jasmin Rousseau, Marilène Paquet, Perrine Garde-Granger, François Boudreau, Nathalie Perreault
Bmps are morphogens involved in various gastric cellular functions. Studies in genetically-modified mice have shown that Bmp disruption in gastric epithelial and stromal cell compartments leads to the development of tumorigenesis. Our studies have demonstrated that abrogation of gastric epithelial Bmp signaling alone was not sufficient to recapitulate the neoplastic features associated with total gastric loss of Bmp signaling. Thus, epithelial Bmp signaling does not appear to be a key player in gastric tumorigenesis initiation...
September 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27551401/genetic-diversity-and-structuring-across-the-range-of-a-widely-distributed-ladybird-focus-on-rear-edge-populations-phenotypically-divergent
#8
Émilie Lecompte, Mohand-Ameziane Bouanani, Alexandra Magro, Brigitte Crouau-Roy
Population genetics and phenotypic structures are often predicted to vary along the geographic range of a species. This phenomenon would be accentuated for species with large range areas, with discontinuities and marginal populations. We herein compare the genetic patterns of central populations of Coccinella septempunctata L. with those of two phenotypically differentiated populations considered as rear-edge populations and subspecies based on phenotype (Algeria and Japan). According to the central-marginal model and expected characteristics of rear-edge populations, we hypothesize that these rear-edge populations have (1) a reduced genetic diversity, resulting from their relative isolation over long periods of time, (2) a higher population genetic differentiation, explained by low contemporary gene flow levels, and (3) a relationship between genetic diversity characteristics and phenotypes, due to historical isolation and/or local adaptation...
August 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27459776/demographic-shifts-related-to-mycoheterotrophy-and-their-fitness-impacts-in-two-cephalanthera-species
#9
Richard P Shefferson, Mélanie Roy, Ülle Püttsepp, Marc-André Selosse
Evolutionary losses of photosynthesis in terrestrial plants all originate in photosynthetic ancestors. The adaptive context under which this transition happens has remained elusive because of the rarity of plants in which both photosynthetic and non-photosynthetic forms exist as a polymorphism. Here, we report on demographic patterns in photosynthetic ("green") and nonphotosynthetic ("albino") individuals within populations of two such species, Cephalanthera damasonium and C. longifolia, which also acquire nutrition from their mycorrhizal hosts (partial mycoheterotrophy)...
June 2016: Ecology
https://www.readbyqxmd.com/read/27426617/conformational-selection-underpins-recognition-of-multiple-dna-sequences-by-proteins-and-consequent-functional-actions
#10
Gitashri Naiya, Paromita Raha, Manas Kumar Mondal, Uttam Pal, Rajesh Saha, Susobhan Chaudhuri, Subrata Batabyal, Samir Kumar Pal, Dhananjay Bhattacharyya, Nakul C Maiti, Siddhartha Roy
Recognition of multiple functional DNA sequences by a DNA-binding protein occurs widely in nature. The physico-chemical basis of this phenomenon is not well-understood. The E. coli gal repressor, a gene regulatory protein, binds two homologous but non-identical sixteen basepair sequences in the gal operon and interacts by protein-protein interaction to regulate gene expression. The two sites have nearly equal affinities for the Gal repressor. Spectroscopic studies of the Gal repressor bound to these two different DNA sequences detected significant conformational differences between them...
August 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27412613/genetic-diversity-and-structure-in-hill-rice-oryza-sativa-l-landraces-from-the-north-eastern-himalayas-of-india
#11
Somnath Roy, B C Marndi, B Mawkhlieng, A Banerjee, R M Yadav, A K Misra, K C Bansal
BACKGROUND: Hill rices (Oryza sativa L.) are direct seeded rices grown on hill slopes of different gradients. These landraces have evolved under rainfed and harsh environmental conditions and may possess genes governing adaptation traits such as tolerance to cold and moisture stress. In this study, 64 hill rice landraces were collected from the state of Arunachal Pradesh of North-Eastern region of India, and assessed by agro-morphological variability and microsatellite markers polymorphism...
2016: BMC Genetics
https://www.readbyqxmd.com/read/27364349/unraveling-the-message-insights-into-comparative-genomics-of-the-naked-mole-rat
#12
REVIEW
Kaitlyn N Lewis, Ilya Soifer, Eugene Melamud, Margaret Roy, R Scott McIsaac, Matthew Hibbs, Rochelle Buffenstein
Animals have evolved to survive, and even thrive, in different environments. Genetic adaptations may have indirectly created phenotypes that also resulted in a longer lifespan. One example of this phenomenon is the preternaturally long-lived naked mole-rat. This strictly subterranean rodent tolerates hypoxia, hypercapnia, and soil-based toxins. Naked mole-rats also exhibit pronounced resistance to cancer and an attenuated decline of many physiological characteristics that often decline as mammals age. Elucidating mechanisms that give rise to their unique phenotypes will lead to better understanding of subterranean ecophysiology and biology of aging...
August 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/27309790/effect-of-treatment-education-based-on-the-roy-adaptation-model-on-adjustment-of-hemodialysis-patients
#13
Ayse Kacaroglu Vicdan, Bilgi Gulseven Karabacak
BACKGROUND: The Roy Adaptation Model examines the individual in 4 fields: physiological mode, self-concept mode, role function mode, and interdependence mode. Hemodialysis treatment is associated with the Roy Adaptation Model as it involves fields that might be needed by the individual with chronic renal disease. PURPOSE: This research was conducted as randomized controlled experiment with the aim of determining the effect of the education given in accordance with the Roy Adaptation Model on physiological, psychological, and social adaptation of individuals undergoing hemodialysis treatment...
July 2016: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27271208/accessible-bioprinting-adaptation-of-a-low-cost-3d-printer-for-precise-cell-placement-and-stem-cell-differentiation
#14
John A Reid, Peter A Mollica, Garett D Johnson, Roy C Ogle, Robert D Bruno, Patrick C Sachs
The precision and repeatability offered by computer-aided design and computer-numerically controlled techniques in biofabrication processes is quickly becoming an industry standard. However, many hurdles still exist before these techniques can be used in research laboratories for cellular and molecular biology applications. Extrusion-based bioprinting systems have been characterized by high development costs, injector clogging, difficulty achieving small cell number deposits, decreased cell viability, and altered cell function post-printing...
June 2016: Biofabrication
https://www.readbyqxmd.com/read/27271135/healing-and-transcendence-a-roy-adaptation-model-guided-comparison
#15
Susan DeSanto-Madeya, Jacqueline Fawcett
Healing and transcendence are concepts of considerable interest to nurses who engage in holistic nursing practice. The two concepts are often used within the context of adaptation to describe the processes experienced by individuals who experience suffering and distress from various life events. Despite their intuitive significance to the human experience, the similarities and differences between the two concepts remains unclear. The purpose of this paper is to present the results of a Roy adaptation model-guided comparison of the two concepts that addresses their shared and distinct characteristics...
July 2016: Nursing Science Quarterly
https://www.readbyqxmd.com/read/27256943/concept-analysis-of-illness-engulfment-in-schizophrenia
#16
Danny Vining, Jennifer C Robinson
Schizophrenia has a significant risk of damaging an individual's self-concept. Through the process of illness engulfment an individual's self-concept becomes reorganized entirely around the experience of having schizophrenia. The purpose of this manuscript is to clarify the structure and function of the concept of illness engulfment in schizophrenia using Walker and Avant's (2011) method of concept analysis. Data came from a review of scholarly literature, as well as contemporary and historical art, literature, music, and other media forms...
June 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27250933/rendering-the-3-3-design-to-rest-more-efficient-approaches-to-oncology-dose-finding-trials-in-the-era-of-targeted-therapy
#17
EDITORIAL
Lei Nie, Eric H Rubin, Nitin Mehrotra, José Pinheiro, Laura L Fernandes, Amit Roy, Stuart Bailey, Dinesh P de Alwis
Selection of the maximum tolerated dose (MTD) as the recommended dose for registration trials based on a dose-escalation trial using variations of an MTD/3 + 3 design often occurs in the development of oncology products. The MTD/3 + 3 approach is not optimal and may result in recommended doses that are unacceptably toxic for many patients and in dose reduction/interruptions that might have an impact on effectiveness. Instead of the MTD/3 + 3 approach, the authors recommend an integrated approach. In this approach, typically an adaptive/Bayesian model provides a general framework to incorporate and make decisions for dose escalation based on nonclinical data, such as animal efficacy and toxicity data; clinical data, including pharmacokinetics/pharmacodynamics data; and dose/exposure-response data for efficacy and safety...
June 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27226559/neutralization-of-rantes-and-eotaxin-prevents-the-loss-of-dopaminergic-neurons-in-a-mouse-model-of-parkinson-disease
#18
Goutam Chandra, Suresh B Rangasamy, Avik Roy, Jeffrey H Kordower, Kalipada Pahan
Parkinson disease (PD) is second only to Alzheimer disease as the most common human neurodegenerative disorder. Despite intense investigation, no interdictive therapy is available for PD. Recent studies indicate that both innate and adaptive immune processes are active in PD. Accordingly, we found a rapid increase in RANTES (regulated on activation normal T cell expressed and secreted) and eotaxin, chemokines that are involved in T cell trafficking, in vivo in the substantia nigra pars compacta and the serum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice...
July 15, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27218110/effect-of-roy-s-adaptation-model-guided-education-on-coping-strategies-of-the-veterans-with-lower-extremities-amputation-a-double-blind-randomized-controlled-clinical-trial
#19
Zahra Farsi, Somayeh Azarmi
BACKGROUND: Any defect in the extremities of the body can affect different life aspects. The purpose of this study was to investigate the effect of Roy's adaptation model-guided education on coping strategies of the veterans with lower extremities amputation. METHODS: In a double-blind randomized controlled clinical trial, 60 veterans with lower extremities amputation referring to Kowsar Orthotics and Prosthetics Center of Veterans Clinic in Tehran, Iran were recruited using convenience method and randomly assigned to intervention and control groups in 2013-2014...
April 2016: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/27215757/understanding-experiences-of-diabetes-medications-among-african-americans-living-with-type-2-diabetes
#20
Denise Bockwoldt, Beth A Staffileno, Lola Coke, Rebekah Hamilton, Lou Fogg, Donna Calvin, Lauretta Quinn
African American (AA) adults are disproportionally affected by type 2 diabetes and are diagnosed at an earlier age, but are less adherent to diabetes medications compared with the general population. This qualitative study sought to describe the experiences of taking diabetes medications among midlife AA men and women with type 2 diabetes and to identify factors that influence these experiences. Fifteen AAs completed semistructured interviews. Using the Roy adaptation model, thematic analysis coded for both adaptive and ineffective experiences...
May 23, 2016: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
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