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https://www.readbyqxmd.com/read/28169299/corrigendum-greenland-subglacial-drainage-evolution-regulated-by-weakly-connected-regions-of-the-bed
#1
Matthew J Hoffman, Lauren C Andrews, Stephen F Price, Ginny A Catania, Thomas A Neumann, Martin P Lüthi, Jason Gulley, Claudia Ryser, Robert L Hawley, Blaine Morriss
No abstract text is available yet for this article.
February 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28129524/her2-testing-and-clinical-decision-making-in-gastroesophageal-adenocarcinoma-guideline-from-the-college-of-american-pathologists-american-society-for-clinical-pathology-and-the-american-society-of-clinical-oncology
#2
Angela N Bartley, Mary Kay Washington, Carol Colasacco, Christina B Ventura, Nofisat Ismaila, Al B Benson, Alfredo Carrato, Margaret L Gulley, Dhanpat Jain, Sanjay Kakar, Helen J Mackay, Catherine Streutker, Laura Tang, Megan Troxell, Jaffer A Ajani
Context ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA. Objectives To establish an evidence-based guideline for HER2 testing in patients with GEA, formalize the algorithms for methods to improve the accuracy of HER2 testing while addressing which patients and tumor specimens are appropriate, and to provide guidance on clinical decision making...
February 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28093093/innovations-for-tomorrow-summary-of-the-2016-disaster-health-education-symposium
#3
Kelly Gulley, Kandra Strauss-Riggs, Thomas D Kirsch, Craig Goolsby
In an effort to enhance education, training, and learning in the disaster health community, the National Center for Disaster Medicine and Public Health (NCDMPH) gathered experts from around the nation in Bethesda, Maryland, on September 8, 2016, for the 2016 Disaster Health Education Symposium: Innovations for Tomorrow. This article summarizes key themes presented during the disaster health symposium including innovations in the following areas: training and education that saves lives, practice, teaching, sharing knowledge, and our communities...
January 17, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28077399/her2-testing-and-clinical-decision-making-in-gastroesophageal-adenocarcinoma-guideline-from-the-college-of-american-pathologists-american-society-for-clinical-pathology-and-american-society-of-clinical-oncology
#4
REVIEW
Angela N Bartley, Mary Kay Washington, Christina B Ventura, Nofisat Ismaila, Carol Colasacco, Al B Benson, Alfredo Carrato, Margaret L Gulley, Dhanpat Jain, Sanjay Kakar, Helen J Mackay, Catherine Streutker, Laura Tang, Megan Troxell, Jaffer A Ajani
CONTEXT: ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with advanced gastroesophageal adenocarcinoma (GEA). However, there are no comprehensive guidelines for the assessment of HER2 in patients with GEA. OBJECTIVES: To establish an evidence-based guideline for HER2 testing in patients with GEA, to formalize the algorithms for methods to improve the accuracy of HER2 testing while addressing which patients and tumor specimens are appropriate, and to provide guidance on clinical decision making...
December 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28038406/beta-hydroxy-beta-methylbutyrate-hmb-ameliorates-age-related-deficits-in-water-maze-performance-especially-in-male-rats
#5
Daniel G Kougias, Emily R Hankosky, Joshua M Gulley, Janice M Juraska
Beta-hydroxy-beta-methylbutyrate (HMB) is commonly supplemented to maintain muscle in elderly and clinical populations and has potential as a nootropic. Previously, we have shown that in both male and female rats, long-term HMB supplementation prevents age-related dendritic shrinkage within the medial prefrontal cortex (mPFC) and improves cognitive flexibility and working memory performance that are both age- and sex-specific. In this study, we further explore the cognitive effects by assessing visuospatial learning and memory with the Morris water maze...
March 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27991518/greenland-subglacial-drainage-evolution-regulated-by-weakly-connected-regions-of-the-bed
#6
Matthew J Hoffman, Lauren C Andrews, Stephen A Price, Ginny A Catania, Thomas A Neumann, Martin P Lüthi, Jason Gulley, Claudia Ryser, Robert L Hawley, Blaine Morriss
Penetration of surface meltwater to the bed of the Greenland Ice Sheet each summer causes an initial increase in ice speed due to elevated basal water pressure, followed by slowdown in late summer that continues into fall and winter. While this seasonal pattern is commonly explained by an evolution of the subglacial drainage system from an inefficient distributed to efficient channelized configuration, mounting evidence indicates that subglacial channels are unable to explain important aspects of hydrodynamic coupling in late summer and fall...
December 19, 2016: Nature Communications
https://www.readbyqxmd.com/read/27751359/karyotypic-abnormalities-associated-with-epstein-barr-virus-status-in-classical-hodgkin-lymphoma
#7
Nathan D Montgomery, Wilborn B Coward, Steven Johnson, Ji Yuan, Margaret L Gulley, Stephanie P Mathews, Kathleen Kaiser-Rogers, Kathleen W Rao, Warren G Sanger, Jennifer N Sanmann, Yuri Fedoriw
Classical Hodgkin lymphoma (CHL) is morphologically characterized by scattered malignant Hodgkin/Reed-Sternberg (HRS) cells that are far outnumbered by surrounding reactive hematolymphoid cells. Approximately half of all cases of CHL are associated with infection by Epstein-Barr virus (EBV), an oncogenic herpesvirus that expresses a number of proteins thought to contribute to transformation. While a small number of published studies have attempted to identify recurrent cytogenetic abnormalities in CHL, no large case series have explored karyotypic differences between EBV-positive and EBV-negative tumors...
September 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27739389/understanding-comorbidity-among-internalizing-problems-integrating-latent-structural-models-of-psychopathology-and-risk-mechanisms
#8
Benjamin L Hankin, Hannah R Snyder, Lauren D Gulley, Tina H Schweizer, Patricia Bijttebier, Sabine Nelis, Gim Toh, Michael W Vasey
It is well known that comorbidity is the rule, not the exception, for categorically defined psychiatric disorders, and this is also the case for internalizing disorders of depression and anxiety. This theoretical review paper addresses the ubiquity of comorbidity among internalizing disorders. Our central thesis is that progress in understanding this co-occurrence can be made by employing latent dimensional structural models that organize psychopathology as well as vulnerabilities and risk mechanisms and by connecting the multiple levels of risk and psychopathology outcomes together...
November 2016: Development and Psychopathology
https://www.readbyqxmd.com/read/27702645/timing-of-amphetamine-exposure-in-relation-to-puberty-onset-determines-its-effects-on-anhedonia-exploratory-behavior-and-dopamine-d1-receptor-expression-in-young-adulthood
#9
Shuo Kang, Mariah M Wu, Roberto Galvez, Joshua M Gulley
Non-medical use of amphetamine (AMPH) among adolescents is prevalent, which is problematic given the potential consequences of developmental drug exposure on brain function and behavior. Previously we found in adult male rats that AMPH exposure starting before puberty induces a persistent decrease in dopamine D1 receptor (D1R) function in the medial prefrontal cortex (mPFC). Here we investigated if this dysfunction was associated with changes in D1R expression in the mPFC and nucleus accumbens (NAc). We also determined if starting drug exposure well before or near the onset of puberty would influence AMPH-induced changes in D1R expression and behavior...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27623471/evaluating-elevated-hemoglobin
#10
LETTER
Brandi N Reeves, Margaret L Gulley
No abstract text is available yet for this article.
September 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27622067/tarp-vaccination-is-associated-with-slowing-in-psa-velocity-and-decreasing-tumor-growth-rates-in-patients-with-stage-d0-prostate-cancer
#11
Lauren V Wood, Antonio Fojo, Brenda D Roberson, Meghan S B Hughes, William Dahut, James L Gulley, Ravi A Madan, Philip M Arlen, Marianna Sabatino, David F Stroncek, Luciano Castiello, Jane B Trepel, Min-Jung Lee, Howard L Parnes, Seth M Steinberg, Masaki Terabe, Julia Wilkerson, Ira Pastan, Jay A Berzofsky
T-cell receptor alternate reading frame protein (TARP) is a 58-residue protein over-expressed in prostate and breast cancer. We investigated TARP peptide vaccination's impact on the rise in PSA (expressed as Slope Log(PSA) or PSA Doubling Time (PSADT)), validated tumor growth measures, and tumor growth rate in men with Stage D0 prostate cancer. HLA-A*0201 positive men were randomized to receive epitope-enhanced (29-37-9V) and wild-type (27-35) TARP peptides administered as a Montanide/GM-CSF peptide emulsion or as an autologous peptide-pulsed dendritic cell vaccine every 3 weeks for a total of five vaccinations with an optional 6th dose of vaccine at 36 weeks based on immune response or PSADT criteria with a booster dose of vaccine for all patients at 48 and 96 weeks...
August 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27553491/predicting-clinical-outcomes-in-chordoma-patients-receiving-immunotherapy-a-comparison-between-volumetric-segmentation-and-recist
#12
Kathleen E Fenerty, Les R Folio, Nicholas J Patronas, Jennifer L Marté, James L Gulley, Christopher R Heery
BACKGROUND: The Response Evaluation Criteria in Solid Tumors (RECIST) are the current standard for evaluating disease progression or therapy response in patients with solid tumors. RECIST 1.1 calls for axial, longest-diameter (or perpendicular short axis of lymph nodes) measurements of a maximum of five tumors, which limits clinicians' ability to adequately measure disease burden, especially in patients with irregularly shaped tumors. This is especially problematic in chordoma, a disease for which RECIST does not always adequately capture disease burden because chordoma tumors are typically irregularly shaped and slow-growing...
August 23, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27486817/samarium-153-edtmp-quadramet%C3%A2-with-or-without-vaccine-in-metastatic-castration-resistant-prostate-cancer-a-randomized-phase-2-trial
#13
Christopher R Heery, Ravi A Madan, Mark N Stein, Walter M Stadler, Robert S Di Paola, Myrna Rauckhorst, Seth M Steinberg, Jennifer L Marté, Clara C Chen, Italia Grenga, Renee N Donahue, Caroline Jochems, William L Dahut, Jeffrey Schlom, James L Gulley
PSA-TRICOM is a therapeutic vaccine in late stage clinical testing in metastatic castration-resistant prostate cancer (mCRPC). Samarium-153-ethylene diamine tetramethylene phosphonate (Sm-153-EDTMP; Quadramet®), a radiopharmaceutical, binds osteoblastic bone lesions and emits beta particles causing local tumor cell destruction. Preclinically, Sm-153-EDTMP alters tumor cell phenotype facilitating immune-mediated killing. This phase 2 multi-center trial randomized patients to Sm-153-EDTMP alone or with PSA-TRICOM vaccine...
18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27485137/analyses-of-pretherapy-peripheral-immunoscore-and-response-to-vaccine-therapy
#14
Benedetto Farsaci, Renee N Donahue, Italia Grenga, Lauren M Lepone, Peter S Kim, Brendan Dempsey, Janet C Siebert, Nuhad K Ibrahim, Ravi A Madan, Christopher R Heery, James L Gulley, Jeffrey Schlom
Tumor immunoscore analyses, especially for primary colorectal cancer and melanoma lesions, provide valuable prognostic information. Metastatic lesions of many carcinoma types, however, are often not easily accessible. We hypothesized that immune cells in peripheral blood may differ among individual patients with metastatic disease, which, in turn, may influence their response to immunotherapy. We thus analyzed immune cell subsets within peripheral blood mononuclear cells to determine if a "peripheral immunoscore" could have any prognostic significance for patients before receiving immunotherapy...
September 2, 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27473889/radium-223-in-prostate-cancer-emitting-the-right-signals
#15
Ravi A Madan, James L Gulley, William L Dahut
No abstract text is available yet for this article.
September 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27471994/immunotherapy-in-genitourinary-malignancies
#16
Max M Wattenberg, Lawrence Fong, Ravi A Madan, James L Gulley
PURPOSE OF REVIEW: Active investigation suggests immune checkpoint inhibitor therapy and therapeutic cancer vaccines provide clinical benefit for genitourinary malignancies including prostate cancer, renal cell carcinoma, and bladder cancer. Recent developments in the utility of immune checkpoint inhibitor and vaccine therapy for the management of genitourinary malignancies are highlighted in this review. RECENT FINDINGS: Dramatic responses to checkpoint inhibitor therapy have been demonstrated in renal cell carcinoma and bladder cancer with recent Food and Drug Administration approvals in both indications...
November 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27328856/a-phase-ii-clinical-trial-of-trc105-anti-endoglin-antibody-in-adults-with-advanced-metastatic-urothelial-carcinoma
#17
Andrea B Apolo, Fatima H Karzai, Jane B Trepel, Sylvia Alarcon, Sunmin Lee, Min-Jung Lee, Yusuke Tomita, Liang Cao, Yunkai Yu, Maria J Merino, Ravi A Madan, Howard L Parnes, Seth M Steinberg, Beatriz Walter Rodriguez, Ben K Seon, James L Gulley, Philip M Arlen, Nancy A Dawson, William D Figg, William L Dahut
BACKGROUND: In this trial we assessed the efficacy and tolerability of TRC105, a chimeric monoclonal antibody that targets CD105 (endoglin) in patients with advanced, previously treated urothelial carcinoma (UC). PATIENTS AND METHODS: Patients received TRC105 15 mg/kg every 2 weeks on days 1 and 15 of each 28-day cycle. The primary end point was progression-free survival (PFS) at 6 months. Secondary end points included safety, toxicity, and overall survival (OS)...
May 27, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27192116/the-ido1-selective-inhibitor-epacadostat-enhances-dendritic-cell-immunogenicity-and-lytic-ability-of-tumor-antigen-specific-t-cells
#18
Caroline Jochems, Massimo Fantini, Romaine I Fernando, Anna R Kwilas, Renee N Donahue, Lauren M Lepone, Italia Grenga, Young-Seung Kim, Martin W Brechbiel, James L Gulley, Ravi A Madan, Christopher R Heery, James W Hodge, Robert Newton, Jeffrey Schlom, Kwong Y Tsang
Epacadostat is a novel inhibitor of indoleamine-2,3-dioxygenase-1 (IDO1) that suppresses systemic tryptophan catabolism and is currently being evaluated in ongoing clinical trials. We investigated the effects of epacadostat on (a) human dendritic cells (DCs) with respect to maturation and ability to activate human tumor antigen-specific cytotoxic T-cell (CTL) lines, and subsequent T-cell lysis of tumor cells, (b) human regulatory T cells (Tregs), and (c) human peripheral blood mononuclear cells (PBMCs) in vitro...
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27141392/perspectives-on-sipuleucel-t-its-role-in-the-prostate-cancer-treatment-paradigm
#19
REVIEW
James L Gulley, Peter Mulders, Peter Albers, Jacques Banchereau, Michel Bolla, Klaus Pantel, Thomas Powles
Sipuleucel-T is an autologous cellular immunotherapy approved in the US for patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). This significant advance for mCRPC treatment provides healthcare professionals with another effective therapy to extend survival. As an immunotherapy, sipuleucel-T possesses specific characteristics differentiating it from traditional therapies. At a roundtable meeting of experts, sipuleucel-T data were discussed, focusing on interpretation and clinical implications...
April 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27135835/nivolumab-anti-programmed-death-1-pd-1-monoclonal-antibody-immunotherapy-role-in-advanced-cancers
#20
Arun Rajan, Chul Kim, Christopher R Heery, Udayan Guha, James L Gulley
The development of immune checkpoint inhibitors has altered the landscape of treatment of advanced cancers. These drugs are well tolerated and have shown clinical activity against a wide variety of solid tumors and hematological malignancies. The durability of response is particularly impressive when compared to other forms of systemic therapy. Nivolumab (Opdivo) is an IgG4 antibody that causes immune checkpoint blockade by diminishing inhibitory signaling through the programmed death receptor-1 pathway. It is approved for treatment of recurrent non-small cell lung cancer, melanoma, and renal cell carcinoma...
September 2016: Human Vaccines & Immunotherapeutics
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