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Advantages of biosynthetic heart valve

Donna M Bates, Christof von Eiff, Peter J McNamara, Georg Peters, Michael R Yeaman, Arnold S Bayer, Richard A Proctor
Small colony variants (SCVs) of Staphylococcus aureus were generated via mutations in menD or hemB, yielding menadione and hemin auxotrophs, respectively, and studied in the rabbit endocarditis model. No differences in the 95% infectious dose occurred between strains with regard to seeding heart valves ( approximately 10(6) cfu) or other target organs. No differences were observed between the response of the hemB mutant to oxacillin therapy and that of the parent strain in any target tissues, and significant reductions in bacterial densities were seen in all tissues (compared with untreated controls)...
May 15, 2003: Journal of Infectious Diseases
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