Read by QxMD icon Read


Kiki Kots, Harold J G Meijer, Klaas Bouwmeester, Francine Govers, Tijs Ketelaar
The oomycete Phytophthora infestans is the cause of late blight in potato and tomato. It is a devastating pathogen and there is an urgent need to design alternative strategies to control the disease. To find novel potential drug targets, we used Lifeact-eGFP expressing P. infestans for high resolution live cell imaging of the actin cytoskeleton in various developmental stages. Previously, we identified actin plaques as structures that are unique for oomycetes. Here we describe two additional novel actin configurations; one associated with plug deposition in germ tubes and the other with appressoria, infection structures formed prior to host cell penetration...
October 6, 2016: Cellular and Molecular Life Sciences: CMLS
Kiki M G J Wigny, Wendy van Dorp, Anne-Lotte L F van der Kooi, Yolanda B de Rijke, Andrica C H de Vries, Marij Smit, Saskia M F Pluijm, Erica L T van den Akker, Rob Pieters, Joop S E Laven, Marry M van den Heuvel-Eibrink
STUDY QUESTION: Are Inhibin B and testosterone levels reduced in boys with newly diagnosed cancer prior to therapy? SUMMARY ANSWER: Pretreatment serum levels of Inhibin B and testosterone are significantly reduced in boys with newly diagnosed cancer, compared to reference values. WHAT IS ALREADY KNOWN: Disease-related gonadal impairment has been demonstrated in girls and young women diagnosed with cancer, prior to therapy. STUDY DESIGN, SIZE, DURATION: We conducted a descriptive study in boys newly diagnosed with cancer between January 2006 and February 2014...
September 28, 2016: Human Reproduction
Hugo F D Almeida, Pedro J Carvalho, Kiki A Kurnia, José A Lopes-da-Silva, João A P Coutinho, Mara G Freire
Ionic liquids (ILs) with cyano-functionalized anions are a set of fluids that are still poorly characterized despite their remarkably low viscosities and potential applications. Aiming at providing a comprehensive study on the influence of the number of -CN groups through the surface tension and surface organization of ILs, the surface tensions of imidazolium-based ILs with cyano-functionalized anions were determined at atmospheric pressure and in the (298.15 to 343.15) K temperature range. The ILs investigated are based on 1-alkyl-3-methylimidazolium cations (alkyl = ethyl, butyl and hexyl) combined with the [SCN](-), [N(CN)2](-), [C(CN)3](-) and [B(CN)4](-)anions...
February 15, 2016: Fluid Phase Equilibria
Mónia A R Martins, Catarina M S S Neves, Kiki A Kurnia, Pedro J Carvalho, Marisa A A Rocha, Luís M N B F Santos, Simão P Pinho, Mara G Freire
In order to evaluate the impact of the alkyl side chain length and symmetry of the cation on the thermophysical properties of water-saturated ionic liquids (ILs), densities and viscosities as a function of temperature were measured at atmospheric pressure and in the (298.15 to 363.15) K temperature range, for systems containing two series of bis(trifluoromethylsulfonyl)imide-based compounds: the symmetric [C n C n im][NTf2] (with n = 1-8 and 10) and asymmetric [C n C1im][NTf2] (with n = 2-5, 7, 9 and 11) ILs...
January 15, 2016: Fluid Phase Equilibria
Kiki M Tarvin, David C Twedt, Eric Monnet
OBJECTIVE: To determine the frequency, nature, and magnitude of gastroesophageal reflux (GER) in dogs with laryngeal paralysis (LP). STUDY DESIGN: Prospective comparative clinical study. ANIMALS: Client-owned dogs with LP and healthy client-owned dogs (n = 6 each). METHODS: Dogs underwent sedated laryngeal examination for diagnosis and grading of bilateral LP and for placement of a nasoesophageal dual pH/impedance probe...
October 2016: Veterinary Surgery: VS
Kiki M J M H Lombarts, Andrew Ferguson, Markus W Hollmann, Bente Malling, Onyebuchi A Arah, M M Berger, E van Gessel, R Hoff, P Houweling, S Loer, S A Padosch, M J Schramm, W S Schlack, L A Steiner, R J Stolker
BACKGROUND: Given the increasing international recognition of clinical teaching as a competency and regulation of residency training, evaluation of anesthesiology faculty teaching is needed. The System for Evaluating Teaching Qualities (SETQ) Smart questionnaires were developed for assessing teaching performance of faculty in residency training programs in different countries. This study investigated (1) the structure, (2) the psychometric qualities of the new tools, and (3) the number of residents' evaluations needed per anesthesiology faculty to use the instruments reliably...
November 2016: Anesthesiology
Lien Desteghe, Lara Engelhard, Zina Raymaekers, Kiki Kluts, Johan Vijgen, Dagmara Dilling-Boer, Pieter Koopman, Joris Schurmans, Paul Dendale, Hein Heidbuchel
OBJECTIVE: The aim of this study was to develop and validate a new questionnaire, the Jessa Atrial fibrillation Knowledge Questionnaire (JAKQ), to test the knowledge of patients with atrial fibrillation (AF) about the arrhythmia, its treatment and their ability for self-management. METHODS: The JAKQ was developed based on other questionnaires, two educational checklists and patient information support websites. The JAKQ was validated based on content validity, face validity, response process, discriminatory potential and sensitivity of the questionnaire, construct validity and reliability...
November 15, 2016: International Journal of Cardiology
Kiki D Chang
Treating bipolar disorder in pediatric patients is challenging because data from rigorous trials of pharmacotherapy in this population are still not plentiful enough. Furthermore, the treatment of children and adolescents is complicated by the frequent need to combine pharmacotherapies to address all bipolar symptoms as well as this population's elevated risk for experiencing side effects. Additionally, young patients with depressive episodes who are at high risk for developing bipolar disorder need careful treatment to prevent or delay the emergence of mania...
2016: Journal of Clinical Psychiatry
Laurens T van der Meer, Samantha Y A Terry, Dorette van Ingen Schenau, Kiki C Andree, Gerben M Franssen, Debbie M Roeleveld, Bart M Metselaar, Thomas Reinheckel, Peter M Hoogerbrugge, Otto C Boerman, Frank N van Leeuwen
: The antileukemic drug asparaginase, a key component in the treatment of acute lymphoblastic leukemia, acts by depleting asparagine from the blood. However, little is known about its pharmacokinetics and mechanisms of therapy resistance are poorly understood. Here, we explored the in vivo biodistribution of radiolabeled asparaginase, using a combination of in vivo imaging and biochemical techniques, and provide evidence for tissue specific clearance mechanisms, which could reduce effectiveness of the drug at these specific sites...
August 4, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Anita D'Urso, Kiki Mastroyannopoulou, Angela Kirby
As survival rates continue to improve for children diagnosed with cancer, strides in achieving better psychosocial outcomes for both children with cancer and their families have been accentuated. The current study aimed to explore the experiences of siblings of children diagnosed with cancer and attempted to overcome some of the limitations described in previous research. Primarily, the study considered the theoretical framework of posttraumatic growth (PTG) in the project design and analysis. Semi-structured interviews were completed with six siblings...
August 4, 2016: Clinical Child Psychology and Psychiatry
Mihai G Netea, Leo A B Joosten, Yang Li, Vinod Kumar, Marije Oosting, Sanne Smeekens, Martin Jaeger, Rob Ter Horst, Melanie Schirmer, Hera Vlamakis, Richard Notebaart, Norman Pavelka, Raul Raul Aguirre-Gamboa, Morris A Swertz, Rahajeng N Tunjungputri, Wouter van de Heijden, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Kiki Schraa, Romana Netea-Maier, Jan Smit, Quirijn de Mast, Frank van de Veerdonk, Bart Jan Kullberg, Cees Tack, Inge van de Munckhof, Joost Rutten, Jacqueline van der Graaf, Lude Franke, Marten Hofker, Iris Jonkers, Mathieu Platteel, Astrid Maatman, Jingyuan Fu, Alexandra Zhernakova, Jos W M van der Meer, Charles A Dinarello, Andre van der Ven, Curtis Huttenhouwer, Hans Koenen, Irma Joosten, Ramnik J Xavier, Cisca Wijmenga
No abstract text is available yet for this article.
August 4, 2016: Nature Medicine
Sethu Karthikeyan, Bianca Rammairone, Vijayachandra Ramachandra
Sound-shape associations involving consistent matching of nonsense words such as 'bouba' and 'kiki' with curved and angular shapes, respectively, have been replicated in several studies. The purpose of the current study was to examine the robustness of previously noted sound-shape associations when shape variations (angular and curvy) are embedded in schematic expressions of emotions (sad and happy). Results revealed consistent matching tendencies based on sound-emotion expression mapping irrespective of the particular shape of the expressions...
January 2016: I-Perception
Robert L Findling, Ronald L Landbloom, Mary Mackle, Xiao Wu, Linda Snow-Adami, Kiki Chang, Suresh Durgam
BACKGROUND: Sublingually administered asenapine was approved in March 2015 by the United States Food and Drug Administration for patients aged 10-17 years with an acute manic or mixed episode associated with bipolar I disorder (BP-1). This is the first long-term safety and tolerability study of asenapine in this population. METHODS: Following the 3-week randomized, double-blind, placebo-controlled trial of patients aged 10-17 years with an acute manic or mixed episode associated with BP-1, patients could enroll in this flexible-dose (2...
October 2016: Paediatric Drugs
Marsha Regenstein, Kiki Nocella, Mariellen Malloy Jewers, Fitzhugh Mullan
Policymakers have long been concerned about the adequacy of the U.S. primary care workforce, especially in rural and low-income areas. In an effort to respond to increased demand for primary care services from new private health insurance markets and Medicaid coverage expansions under the..
August 18, 2016: New England Journal of Medicine
Roberta Etzi, Charles Spence, Massimiliano Zampini, Alberto Gallace
Over the last decade, scientists working on the topic of multisensory integration, as well as designers and marketers involved in trying to understand consumer behavior, have become increasingly interested in the non-arbitrary associations (e.g., sound symbolism) between different sensorial attributes of the stimuli they work with. Nevertheless, to date, little research in this area has investigated the presence of these crossmodal correspondences in the tactile evaluation of everyday materials. Here, we explore the presence and nature of the associations between tactile sensations, the sound of non-words, and people's emotional states...
2016: Multisensory Research
Maaike Krikke, Kiki Tesselaar, Joop E Arends, Julia Drylewicz, Sigrid A Otto, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman
BACKGROUND: The increased risk of abacavir in cardiovascular disease (CVD) in HIV-infected patients is still being debated. Maraviroc, a CCR5 blocker, has been shown to decrease immune activation and monocyte infiltration in atherosclerotic plaques in murine experiments. Therefore, we examined the effect of maraviroc intensification on flow-mediated dilatation (FMD) in abacavir-treated HIV-infected patients and its effect on immunological and inflammatory parameters. METHODS: A open-label prospective crossover study with a duration of 16 weeks: 8 weeks of intervention (maraviroc intensification) and 8 weeks of control (unchanged cART regimen)...
September 2016: Infectious Diseases and Therapy
Yi-Chuan Chen, Pi-Chun Huang, Andy Woods, Charles Spence
It has been suggested that the Bouba/Kiki effect, in which meaningless speech sounds are systematically mapped onto rounded or angular shapes, reflects a universal crossmodal correspondence between audition and vision. Here, radial frequency (RF) patterns were adapted in order to compare the Bouba/Kiki effect in Eastern and Western participants demonstrating different perceptual styles. Three attributes of the RF patterns were manipulated: The frequency, amplitude, and spikiness of the sinusoidal modulations along the circumference of a circle...
2016: Scientific Reports
Yohana Azhar, Dimyati Achmad, Kiki Lukman, Dany Hilmanto, Teguh Aryandono
BACKGROUND: The study aimed to assess complementary and alternative medicine (CAM) use and their associated factors with breast cancer patients in Bandung, Indonesia. MATERIALS AND METHODS: In total, 330 breast cancer patients were administered questionnaires on their CAM use and CAM predictive factors including socio-demographic parameters, clinical data and quality of life, trust in physicians, trust in hospitals, satisfaction and informational needs. Data were analyzed using univariate analysis and multivariate log regreesion analysis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Ourania Preventza, Andrea Garcia, Sarang A Kashyap, Shahab Akvan, Denton A Cooley, Kiki Simpson, Athina Rammou, Matt D Price, Shuab Omer, Faisal G Bakaeen, Lorraine D Cornwell, Joseph S Coselli
OBJECTIVES: To determine whether, in patients with previous cardiac operations, moderate hypothermia (between 24 and 28°C) for hypothermic circulatory arrest (HCA) during antegrade cerebral perfusion (ACP) is safe for use during surgery on the proximal aorta and transverse aortic arch. METHODS: Over a 7-year period, 118 patients underwent ascending aortic and hemiarch repair (n = 70; 59.3%), total arch replacement (n = 47; 39.8%) or ascending aortic replacement to treat porcelain aorta (n = 1; 0...
May 17, 2016: European Journal of Cardio-thoracic Surgery
Kiki C Andree, Ana M C Barradas, Ai T Nguyen, Anouk Mentink, Ivan Stojanovic, Jacob Baggerman, Joost van Dalum, Cees J M van Rijn, Leon W M M Terstappen
The presence of tumor cells in blood is predictive of short survival in several cancers and their isolation and characterization can guide toward the use of more effective treatments. These circulating tumor cells (CTC) are, however, extremely rare and require a technology that is sufficiently sensitive and specific to identify CTC against a background of billions of blood cells. Immuno-capture of cells expressing the epithelial cell adhesion molecule (EpCAM) are frequently used to enrich CTC from blood. The choice of bio conjugation strategy and antibody clone is crucial for adequate cell capture but is poorly understood...
June 15, 2016: ACS Applied Materials & Interfaces
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"