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https://www.readbyqxmd.com/read/29148425/ex-vivo-inhibited-cytokine-profiling-explains-inferior-treatment-response-to-golimumab-after-adalimumab-failure-in-rheumatoid-arthritis
#1
Lieke Tweehuysen, Kiki Schraa, Mihai G Netea, Frank H J van den Hoogen, Leo A B Joosten, Alfons A den Broeder
OBJECTIVES: Clinical data suggest that the response of rheumatoid arthritis patients to treatment with golimumab is much lower among those who switched from adalimumab than among those who switched from etanercept. To elucidate the mechanism behind this difference in response to sequential biologic treatment, we examined the effect of TNF inhibitors on ex vivo cytokine production profiling. METHODS: In a prospective cohort study, blood samples were obtained from patients before the start of a biologic...
October 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29126627/-clinical-and-mycological-characteristics-of-onychomycosis-due-to-candida-at-institut-pasteur-of-c%C3%A3-te-d-ivoire
#2
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29092572/localization-of-complex-sounds-is-modulated-by-behavioral-relevance-and-sound-category
#3
Kiki Derey, Josef P Rauschecker, Elia Formisano, Giancarlo Valente, Beatrice de Gelder
Meaningful sounds represent the majority of sounds that humans hear and process in everyday life. Yet studies of human sound localization mainly use artificial stimuli such as clicks, pure tones, and noise bursts. The present study investigated the influence of behavioral relevance, sound category, and acoustic properties on the localization of complex, meaningful sounds in the horizontal plane. Participants localized vocalizations and traffic sounds with two levels of behavioral relevance (low and high) within each category, as well as amplitude-modulated tones...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29090374/victor-m-rios-human-target-schools-police-and-the-criminalization-of-latino-youth-the-university-of-chicago-press-chicago-il-2017-224-pp-isbn-9780226090993
#4
Eurielle Kiki
No abstract text is available yet for this article.
October 31, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29067550/stability-of-the-pregnancy-obsessive-compulsive-personality-disorder-symptoms-checklist
#5
Kiki E M van Broekhoven, Annemiek Karreman, Esther E Hartman, Victor J M Pop
Because stability over time is central to the definition of personality disorder, aim of the current study was to determine the stability of the Pregnancy Obsessive-Compulsive Personality Disorder (OCPD) Symptoms Checklist (N = 199 women). Strong positive correlations between assessments at 32 weeks of pregnancy and 2 and 3-3.5 years after childbirth were found (r between .62-.72), and the group mean score did not change over time. The Pregnancy OCPD Symptoms Checklist assesses stable, trait-like symptoms of OCPD...
October 24, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29029283/trajectories-of-cardiorespiratory-fitness-in-patients-with-juvenile-dermatomyositis
#6
Kiki J Blom, Tim Takken, Barbara C H Huijgen, Judith Wienke, Annet van Royen-Kerkhof, Marco van Brussel
Objectives: Previous research demonstrated decreased cardiorespiratory fitness (CRF) in patients with JDM during active disease and remission. However, longitudinal data regarding trajectories of CRF are currently lacking. The objective of this study was to determine trajectories of CRF in patients with both monocyclic and chronic JDM, and to identify potential predictors of these trajectories. Methods: Thirty-six patients with JDM [median age (interquartile range) at diagnosis: 8...
September 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28987967/the-bouba-kiki-effect-and-its-relation-to-the-autism-quotient-aq-in-autistic-adolescents
#7
Rinat Gold, Osnat Segal
The bouba-kiki effect refers to the correspondence between arbitrary visual and auditory stimuli. Previous studies indicate ASD persons' reduced bouba-kiki effect compared to controls. This study examines the relation between ASD symptomology and performance on the bouba-kiki task. Twenty ASD participants and 20 matched controls were presented the bouba-kiki task. Autism-Quotient (AQ) scores and several cognitive measures were obtained for all participants. Results demonstrate that among all measures, only AQ scores were significantly correlated to the performance on the bouba-kiki task in the ASD group...
October 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28953570/the-association-between-learning-climate-and-adverse-obstetrical-outcomes-in-16-nontertiary-obstetrics-gynecology-departments-in-the-netherlands
#8
Alina Smirnova, Anita C J Ravelli, Renée E Stalmeijer, Onyebuchi A Arah, Maas Jan Heineman, Cees P M van der Vleuten, Joris A M van der Post, Kiki M J M H Lombarts
PURPOSE: To investigate the association between learning climate and adverse perinatal and maternal outcomes in obstetrics-gynecology departments. METHOD: The authors analyzed 23,629 births and 103 learning climate evaluations from 16 nontertiary obstetrics-gynecology departments in the Netherlands in 2013. Multilevel logistic regressions were used to calculate the odds of adverse perinatal and maternal outcomes, by learning climate score tertile, adjusting for maternal and department characteristics...
September 26, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28944987/the-international-society-for-bipolar-disorders-task-force-report-on-pediatric-bipolar-disorder-knowledge-to-date-and-directions-for-future-research
#9
Benjamin I Goldstein, Boris Birmaher, Gabrielle A Carlson, Melissa P DelBello, Robert L Findling, Mary Fristad, Robert A Kowatch, David J Miklowitz, Fabiano G Nery, Guillermo Perez-Algorta, Anna Van Meter, Cristian P Zeni, Christoph U Correll, Hyo-Won Kim, Janet Wozniak, Kiki D Chang, Manon Hillegers, Eric A Youngstrom
OBJECTIVES: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. METHODS: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps...
September 25, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28922591/baseline-characteristics-and-early-response-at-week-1-predict-treatment-outcome-in-adolescents-with-bipolar-manic-or-mixed-episode-treated-with-olanzapine-results-from-a-3-week-randomized-placebo-controlled-trial
#10
Le Xiao, Stephen J Ganocy, Robert L Findling, Kiki Chang, Melissa P DelBello, John M Kane, Mauricio Tohen, Yu-Tao Xiang, Christoph U Correll
BACKGROUND: Early predictors of response and remission in pediatric mania are lacking, requiring further study. METHODS: This was a post hoc analysis of a 3-week, randomized, placebo-controlled trial of olanzapine conducted between November 2002 and May 2005 in 161 adolescents aged 13-17 years who were diagnosed with a DSM-IV acute manic or mixed episode of bipolar I disorder. Data from the olanzapine arm were analyzed to investigate the predictive power of early response or early nonresponse (≥25% or < 25% reduction in Young Mania Rating Scale [YMRS] score, respectively) at week 1 for ultimate response or nonresponse (≥ 50% or < 50% reduction in YMRS score, respectively) and for remission (YMRS total score ≤ 12 [standard definition] or ≤ 8 [stringent definition]) at week 3...
September 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28890777/when-does-maluma-takete-fail-two-key-failures-and-a-meta-analysis-suggest-that-phonology-and-phonotactics-matter
#11
Suzy J Styles, Lauren Gawne
Eighty-seven years ago, Köhler reported that the majority of students picked the same answer in a quiz: Which novel word form ('maluma' or 'takete') went best with which abstract line drawing (one curved, one angular). Others have consistently shown the effect in a variety of contexts, with only one reported failure by Rogers and Ross. In the spirit of transparency, we report our own failure in the same journal. In our study, speakers of Syuba, from the Himalaya in Nepal, do not show a preference when matching word forms 'kiki' and 'bubu' to spiky versus curvy shapes...
July 2017: I-Perception
https://www.readbyqxmd.com/read/28887005/-fungal-aetiologies-and-contributing-factors-of-interdigital-tinea-pedis-among-policemen-in-abidjan-ivory-coast
#12
P C M Kiki-Barro, A Konaté, E K Angora, F K Kassi, H Bosson-Vanga, A V Bedia-Tanoh, V Djohan, W Yavo, E I H Menan
AIM OF THE STUDY: Fungal interdigital tinea pedis are poorly documented in Ivory Coast. This study aimed to determine the distribution of fungal species and contributing factors of the disease among policemen in Abidjan. PATIENTS AND METHODS: Our cross-sectional study was carried out at the police school in Abidjan. Our patients consisted of symptomatic or non-symptomatic police students. Samples of scales or serosities taken from inter-toes spaces were examinated with KOH mount and cultured on Sabouraud-chloramphenicol and Sabouraud-chloramphenicol-actidione media...
September 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28887004/-mycological-profile-of-hand-onychomycosis-amongs-garba-sellers-in-abidjan-c%C3%A3-te-d-ivoire
#13
P C M Kiki-Barro, A Konaté, F K Kassi, E K Angora, H Bosson-Vanga, A V Bedia-Tanoh, V Djohan, W Yavo, E I H Menan
OBJECTIVE: The aim of this study is to determine the prevalence and the fungi involved in onychomycosis located on fingers in Abidjan. MATERIAL AND METHODS: This study includes the sellers of cooked cassava semolina served with fried tuna fish called "garba". Fines squames specimen was processed with 30% KOH for a direct microscope examination. Serous collection were done in physiological serum. Part of the original sample was cultured on Sabouraud medium with antibiotics (chloramphénicol, actidione)...
September 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28870297/amygdalar-prefrontal-connectivity-changes-during-adolescence-implications-for-development-of-mood-disorders
#14
Kiki D Chang
No abstract text is available yet for this article.
October 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#15
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28837013/six-change-ideas-that-significantly-minimize-alternate-level-of-care-alc-days-in-acute-care-hospitals
#16
Paula Chidwick, Jill Oliver, Daniel Ball, Christopher Parkes, Terri Lynn Hansen, Francesca Fiumara, Kiki Ferrari, Cindy Hawkswell, Karyn Lumsden
A significant issue affecting the healthcare system across Ontario is the number of patients admitted to hospitals that are then subsequently being designated alternate level of care (ALC). In 2016, 14.5% of Ontario in-patient beds were occupied by ALC-designated patients. Contributing to this phenomenon are ethical errors that can affect decision-making around discharge. Since 2012, William Osler Health System has redesigned their discharge process to eliminate ethical errors and align more fully with the Health Care Consent Act (HCCA) and the Public Hospitals Act (PHA)...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28829364/nature-versus-nurture-does-proteostasis-imbalance-underlie-the-genetic-environmental-and-age-related-risk-factors-for-alzheimer-s-disease
#17
REVIEW
Elise A Kikis
Aging is a risk factor for a number of "age-related diseases", including Alzheimer's disease (AD). AD affects more than a third of all people over the age of 85, and is the leading cause of dementia worldwide. Symptoms include forgetfulness, memory loss, and cognitive decline, ultimately resulting in the need for full-time care. While there is no cure for AD, pharmacological approaches to alleviate symptoms and target underlying causes of the disease have been developed, albeit with limited success. This review presents the age-related, genetic, and environmental risk factors for AD and proposes a hypothesis for the mechanistic link between genetics and the environment...
August 22, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28824653/dynamics-of-recent-thymic-emigrants-in-young-adult-mice
#18
Vera van Hoeven, Julia Drylewicz, Liset Westera, Ineke den Braber, Tendai Mugwagwa, Kiki Tesselaar, José A M Borghans, Rob J de Boer
The peripheral naive T-cell pool is generally thought to consist of a subpopulation of recent thymic emigrants (RTEs) and a subpopulation of mature naive (MN) T cells with different dynamics. Thymus transplantation and adoptive transfer studies in mice have provided contradicting results, with some studies suggesting that RTEs are relatively short-lived cells, while another study suggested that RTEs have a survival advantage. We here estimate the death rates of RTE and MN T cells by performing both thymus transplantations and deuterium labeling experiments in mice of at least 12 weeks old, an age at which the size of the T-cell pool has stabilized...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28776930/early-intervention-for-youth-at-high-risk-for-bipolar-disorder-a-multisite-randomized-trial-of-family-focused-treatment
#19
David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang
AIMS: Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD. METHODS: Participants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28743715/circulatory-and-maturation-kinetics-of-human-monocyte-subsets-in-vivo
#20
Tamar Tak, Julia Drylewicz, Lennart Conemans, Rob J De Boer, Leo Koenderman, Jose A M Borghans, Kiki Tesselaar
No abstract text is available yet for this article.
July 25, 2017: Blood
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