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https://www.readbyqxmd.com/read/28776930/early-intervention-for-youth-at-high-risk-for-bipolar-disorder-a-multisite-randomized-trial-of-family-focused-treatment
#1
David J Miklowitz, Christopher D Schneck, Patricia D Walshaw, Amy S Garrett, Manpreet K Singh, Catherine A Sugar, Kiki D Chang
AIMS: Despite the considerable public health impact of bipolar disorder (BD), no psychosocial interventions have been systematically evaluated in its early prodromal stages. We describe the rationale, design and analytic methods for a 3-site randomized trial of family-focused treatment for youth at high risk (FFT-HR) for BD. METHODS: Participants (ages 9-17 years) have a diagnosis of unspecified BD or major depressive disorder, current mood symptoms and at least one first- or second-degree relative with a lifetime history of BD I or II...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28743715/circulatory-and-maturation-kinetics-of-human-monocyte-subsets-in-vivo
#2
Tamar Tak, Julia Drylewicz, Lennart Conemans, Rob J De Boer, Leo Koenderman, Jose A M Borghans, Kiki Tesselaar
No abstract text is available yet for this article.
July 25, 2017: Blood
https://www.readbyqxmd.com/read/28731778/a-pharmacologic-algorithm-for-youth-who-are-at-high-risk-for-bipolar-disorder
#3
Christopher D Schneck, Kiki D Chang, Manpreet K Singh, Melissa P DelBello, David J Miklowitz
OBJECTIVE: Depression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD. METHODS: Subjects were 40 youth (mean 12...
July 21, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28724512/the-health-buddies-app-as-a-novel-tool-to-improve-adherence-and-knowledge-in-atrial-fibrillation-patients-a-pilot-study
#4
Lien Desteghe, Kiki Kluts, Johan Vijgen, Pieter Koopman, Dagmara Dilling-Boer, Joris Schurmans, Paul Dendale, Hein Heidbuchel
BACKGROUND: Atrial fibrillation (AF) constitutes an important risk for stroke, especially in an ageing population. A new app (Health Buddies) was developed as a tool to improve adherence to non-vitamin K antagonist oral anticoagulants (NOACs) in an elderly AF population by providing a virtual contract with their grandchildren, spelling out daily challenges for both. OBJECTIVE: The aim of this pilot study was to assess the feasibility and usability of the Health Buddies app in AF patients...
July 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28722481/clinical-management-of-pediatric-acute-onset-neuropsychiatric-syndrome-part-i-psychiatric-and-behavioral-interventions
#5
Margo Thienemann, Tanya Murphy, James Leckman, Richard Shaw, Kyle Williams, Cynthia Kapphahn, Jennifer Frankovich, Daniel Geller, Gail Bernstein, Kiki Chang, Josephine Elia, Susan Swedo
OBJECTIVE: This article outlines the consensus guidelines for symptomatic treatment for children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Syndrome Associated with Streptococcal Infection (PANDAS). METHODS: Extant literature on behavioral, psychotherapeutic, and psychopharmacologic treatments for PANS and PANDAS was reviewed. Members of the PANS Research Consortium pooled their clinical experiences to find agreement on treatment of PANS and PANDAS symptoms...
July 19, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28691750/human-neonatal-thymectomy-induces-altered-b-cell-responses-and-auto-reactivity
#6
Theo Broek, Asaf Madi, Eveline M Delemarre, Alvin W L Schadenberg, Kiki Tesselaar, José A M Borghans, Stefan Nierkens, Frank A Redegeld, Henny G Otten, Maura Rosetti, Salvatore Albani, Rachel Sorek, Irun R Cohen, Nicolaas J G Jansen, Femke van Wijk
An association between T-cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T-cell lymphopenia affects B-cell responses to auto-antigens. Human neonatal thymectomy results in a decrease in T-cell numbers and we used this model to study the development of auto-reactivity. Two cohorts of neonatally thymectomized individuals were examined, a cohort of young (1-5 years post-thymectomy, n = 10-27) and older children (>10years,n = 26), and compared to healthy age-matched controls...
July 10, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28667891/anomalous-prefrontal-limbic-activation-and-connectivity-in-youth-at-high-risk-for-bipolar-disorder
#7
Kiki Chang, Amy Garrett, Ryan Kelley, Meghan Howe, Erica Marie Sanders, Tenah Acquaye, Layla Bararpour, Sherrie Li, Manpreet Singh, Booil Jo, Joachim Hallmayer, Allan Reiss
OBJECTIVE: Abnormal prefrontal-limbic brain activation in response to facial expressions has been reported in pediatric bipolar disorder (BD). However, it is less clear whether these abnormalities exist prior to onset of mania, thus representing a biomarker predicting development of BD. METHODS: We examined brain activation in 50 youth at high risk for BD (HR-BD), compared with 29 age- and gender-matched healthy control (HC) subjects. HR-BD was defined as having a parent with BD, as well as current mood or attentiondeficit/ hyperactivity disorder (ADHD) symptoms, or a history of at least one depressive episode...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28597194/a-social-bouba-kiki-effect-a-bias-for-people-whose-names-match-their-faces
#8
David N Barton, Jamin Halberstadt
The "bouba/kiki effect" is the robust tendency to associate rounded objects (vs. angular objects) with names that require rounding of the mouth to pronounce, and may reflect synesthesia-like mapping across perceptual modalities. Here we show for the first time a "social" bouba/kiki effect, such that experimental participants associate round names ("Bob," "Lou") with round-faced (vs. angular-faced) individuals. Moreover, consistent with a bias for expectancy-consistent information, we find that participants like targets with "matching" names, both when name-face fit is measured and when it is experimentally manipulated...
June 8, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28577536/how-changing-quality-management-influenced-pgme-accreditation-a-focus-on-decentralization-and-quality-improvement
#9
Nesibe Akdemir, Kiki M J M H Lombarts, Emma Paternotte, Bas Schreuder, Fedde Scheele
BACKGROUND: Evaluating the quality of postgraduate medical education (PGME) programs through accreditation is common practice worldwide. Accreditation is shaped by educational quality and quality management. An appropriate accreditation design is important, as it may drive improvements in training. Moreover, accreditors determine whether a PGME program passes the assessment, which may have major consequences, such as starting, continuing or discontinuing PGME. However, there is limited evidence for the benefits of different choices in accreditation design...
June 2, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28554254/implementation-of-the-hyaluronic-acid-fat-graft-myringoplasty-technique-pitfalls-and-lessons-learned
#10
Nienke Grotenhuis, Jan Pieter Koopman, J Kruyt, Laura Kiki Rothuizen, Rachel Knevel, Henk Blom
BACKGROUND: Myringoplasty is a common procedure in otorhinolaryngology. Many techniques with different complications and outcomes have been described, one of which is hyaluronic acid fat graft myringoplasty (HAFGM). This technique, as proposed by Saliba, uses fat tissue and hyaluronic acid discs. The technique is relatively fast with a high success rate and low complications. However, what outcomes can be expected when performed by other surgeons? In this paper, we report on the technique's success in our own hands...
May 29, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28515092/human-cd62l-dim-neutrophils-identified-as-a-separate-subset-by-proteome-profiling-and-in-vivo-pulse-chase-labelling
#11
Tamar Tak, Patrick Wijten, Marjolein Heeres, Peter Pickkers, Arjen Scholten, Albert J R Heck, Nienke Vrisekoop, Luke P Leenen, Jos Eacute A M Borghans, Kiki Tesselaar, Leo Koenderman
During acute inflammation three neutrophil subsets are found in the blood: neutrophils with a conventional segmented nucleus, neutrophils with a banded nucleus and T-cell-suppressing CD62L(dim) neutrophils with a high number of nuclear lobes. In this study (clinicaltrials.gov NCT01766414) we compared the in vivo kinetics and proteomes of banded, mature and hypersegmented neutrophils to determine whether these cell types represent truly different neutrophil subsets or reflect changes induced by LPS activation...
May 17, 2017: Blood
https://www.readbyqxmd.com/read/28507749/splenic-volume-differentiates-complicated-and-non-complicated-celiac-disease
#12
Tom van Gils, Petula Nijeboer, Jan Hein Tm van Waesberghe, Veerle Mh Coupé, Kiki Janssen, Jessy A Zegers, Shaikh A Nurmohamed, Georg Kraal, Sabine Ci Jiskoot, Gerd Bouma, Chris Jj Mulder
BACKGROUND: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). OBJECTIVE: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. METHODS: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28503811/the-interactive-origin-of-iconicity
#13
Mónica Tamariz, Seán G Roberts, J Isidro Martínez, Julio Santiago
We investigate the emergence of iconicity, specifically a bouba-kiki effect in miniature artificial languages under different functional constraints: when the languages are reproduced and when they are used communicatively. We ran transmission chains of (a) participant dyads who played an interactive communicative game and (b) individual participants who played a matched learning game. An analysis of the languages over six generations in an iterated learning experiment revealed that in the Communication condition, but not in the Reproduction condition, words for spiky shapes tend to be rated by naive judges as more spiky than the words for round shapes...
May 15, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28481049/comparison-of-laparoscopic-assisted-technique-and-open-laparotomy-for-gastrointestinal-biopsy-in-cats
#14
Janet Kovak McClaran, Suzanne C Skerrett, Rachael L Currao, Philippa R Pavia, Kiki M Tarvin
OBJECTIVE: To evaluate and compare the complications, postoperative pain, surgical time, hospitalization time, and adequacy of biopsy specimens between laparoscopic assisted (LAP) versus open laparotomy (OPEN) gastrointestinal biopsies in cats. STUDY DESIGN: Prospective randomized clinical study. SAMPLE POPULATION: Twenty-eight cats with clinical and ultrasonographic evidence of gastrointestinal disease. Fifteen cats in the LAP group and 13 in the OPEN group...
May 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28471782/job-resources-physician-work-engagement-and-patient-care-experience-in-an-academic-medical-setting
#15
Renée A Scheepers, Lenny S S Lases, Onyebuchi A Arah, Maas Jan Heineman, Kiki M J M H Lombarts
PURPOSE: Physician work engagement is associated with better work performance and fewer medical errors; however, whether work-engaged physicians perform better from the patient perspective is unknown. Although availability of job resources (autonomy, colleague support, participation in decision making, opportunities for learning) bolster work engagement, this relationship is understudied among physicians. This study investigated associations of physician work engagement with patient care experience and job resources in an academic setting...
May 2, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28447082/temperature-dependency-of-aqueous-biphasic-systems-an-alternative-approach-for-exploring-the-differences-between-coulombic-dominated-salts-and-ionic-liquids
#16
Francisca A E Silva, Jorge F B Pereira, Kiki A Kurnia, Sónia P M Ventura, Artur M S Silva, Robin D Rogers, João A P Coutinho, Mara G Freire
Herein we propose an alternative way to distinguish ionic liquids from Coulombic-dominated salts, based not on their upper limit melting temperature (100 °C), but on the trend of their phase-forming abilities to create aqueous biphasic systems as a function of temperature, in which a wider plethora of interactions can be appraised.
July 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28379043/hiv-and-risk-of-cardiovascular-disease-in-sub-saharan-africa-rationale-and-design-of-the-ndlovu-cohort-study
#17
Alinda Vos, Hugo Tempelman, Walter Devillé, Roos Barth, Annemarie Wensing, Mirjam Kretzschmar, Kerstin Klipstein-Grobusch, Andy Hoepelman, Kiki Tesselaar, Sue Aitken, Mashudu Madzivhandila, Cuno Uiterwaal, Francois Venter, Roel Coutinho, Diederick E Grobbee
Background The largest proportion of people living with HIV resides in sub-Saharan Africa (SSA). Evidence from developed countries suggests that HIV infection increases the relative risk of cardiovascular disease (CVD) by up to 50%. Differences in lifestyle, gender distribution, routes of HIV transmission and HIV subtype preclude generalisation of data from Western countries to the SSA situation. The Ndlovu Cohort Study aims to provide insight into the burden of cardiovascular risk factors and disease, the mechanisms driving CVD risk and the contribution of HIV infection and its treatment to the development of CVD in a rural area of SSA...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28353480/what-s-your-agility-ability
#18
Kiki Orski
No abstract text is available yet for this article.
April 2017: Nursing Management
https://www.readbyqxmd.com/read/28332847/phase-behavior-and-physical-properties-of-new-biobased-ionic-liquid-crystals
#19
Ariel A C Toledo Hijo, Guilherme J Maximo, Mariana C Costa, Rosiane L Cunha, Jorge F B Pereira, Kiki A Kurnia, Eduardo A C Batista, Antonio J A Meirelles
Protic ionic liquids (PILs) have emerged as promising compounds and attracted the interest of the industry and the academy community, due to their easy preparation and unique properties. In the context of green chemistry, the use of biocompounds, such as fatty acids, for their synthesis could disclose a possible alternative way to produce ILs with a low or nontoxic effect and, consequently, expanding their applicability in biobased processes or in the development of bioproducts. This work addressed efforts to a better comprehension of the complex solid-[liquid crystal]-liquid thermodynamic equilibrium of 20 new PILs synthesized by using fatty acids commonly found in vegetable oils, as well as their rheological profile and self-assembling ability...
March 30, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28282438/a-new-caenorhabditis-elegans-model-of-human-huntingtin-513-aggregation-and-toxicity-in-body-wall-muscles
#20
Amy L Lee, Hailey M Ung, L Paul Sands, Elise A Kikis
Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age. One such disorder is Huntington's Disease (HD) that is caused by a polyglutamine expansion in the human huntingtin protein (htt). The polyglutamine expansion destabilizes htt leading to protein misfolding, which in turn triggers neurodegeneration and the disruption of energy metabolism in muscle cells...
2017: PloS One
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