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Mathilde Fort, Imme Lammertink, Sharon Peperkamp, Adriana Guevara-Rukoz, Paula Fikkert, Sho Tsuji
Adults and toddlers systematically associate pseudowords such as "bouba" and "kiki" with round and spiky shapes, respectively, a sound symbolic phenomenon known as the "bouba-kiki effect". To date, whether this sound symbolic effect is a property of the infant brain present at birth or is a learned aspect of language perception remains unknown. Yet, solving this question is fundamental for our understanding of early language acquisition. Indeed, an early sensitivity to such sound symbolic associations could provide a powerful mechanism for language learning, playing a bootstrapping role in the establishment of novel sound-meaning associations...
March 15, 2018: Developmental Science
Abdullah Tahir Şensoy, Irfan Kaymaz, Ümit Ertaş, Ali Kiki
PURPOSE: The purpose of this study is to suggest a patient-specific osteotomy line to optimize the distractor position and thus to minimize the disadvantages of conventional mandibular distraction osteogenesis (MDO) protocols. In addition, this study also aims to compare the conventional MDO protocols with the new MDO protocol proposed in this study in terms of both orthodontic outcomes and mechanical effects of osteotomy level on callus stabilization by means of the finite element method...
March 8, 2018: Journal of Craniofacial Surgery
Emre Tekgündüz, Mehmet Yılmaz, Mehmet Ali Erkurt, Ilhami Kiki, Ali Hakan Kaya, Leylagul Kaynar, Inci Alacacioglu, Guven Cetin, Ibrahim Ozarslan, Irfan Kuku, Gulden Sincan, Ozan Salim, Sinem Namdaroglu, Abdullah Karakus, Volkan Karakus, Fevzi Altuntas, Ismail Sari, Gulsum Ozet, Ismet Aydogdu, Vahap Okan, Emin Kaya, Rahsan Yildirim, Esra Yildizhan, Gokhan Ozgur, Osman Ilhami Ozcebe, Bahriye Payzin, Seval Akpinar, Fatih Demirkan
Thrombotic microangiopathies (TMAs) are rare, but life-threatening disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia (MAHAT) associated with multiorgan dysfunction as a result of microvascular thrombosis and tissue ischemia. The differentiation of the etiology is of utmost importance as the pathophysiological basis will dictate the choice of appropriate treatment. We retrospectively evaluated 154 (99 females and 55 males) patients who received therapeutic plasma exchange (TPE) due to a presumptive diagnosis of TMA, who had serum ADAMTS13 activity/anti-ADAMTS13 antibody analysis at the time of hospital admission...
February 20, 2018: Transfusion and Apheresis Science
Edward Walter, Kiki Steel
No abstract text is available yet for this article.
March 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Bumjo Oh, Dong-Hun Han, Kyu-Tae Han, Xibei Liu, Johnson Ukken, Carina Chang, Kiki Dounis, Ji Won Yoo
BACKGROUND: It has been suggested that tooth loss in later life might increase dementia incidence. The objective of this analysis is to systematically review the current evidence on the relationship between the number of remaining teeth and dementia occurrence in later life. METHODS: A search of multiple databases of scientific literature was conducted with relevant parameters for articles published up to March 25th, 2017. Multiple cohort studies that reported the incidence of dementia and residual teeth in later life were found with observation periods ranging from 2...
February 17, 2018: BMC Geriatrics
Kiki M M De Jonge, Eric F Rietzschel, Nico W Van Yperen
In the current research, we aimed to address the inconsistent finding in the brainstorming literature that cognitive stimulation sometimes results from novel input, yet other times from non-novel input. We expected and found, in three experiments, that the strength and valence of this relationship are moderated by people's psychological needs for structure and autonomy. Specifically, the effect of novel input (vs. non-novel input), through perceived creativity, on cognitive stimulation was stronger for people who were either low in need for structure or high in need for autonomy...
February 1, 2018: Personality & Social Psychology Bulletin
Ricardo Cortez Cardoso Penha, Simona Pellecchia, Roberto Pacelli, Luis Felipe Ribeiro Pinto, Alfredo Fusco
BACKGROUND: Ionizing Radiation (IR) is a well-known risk factor for papillary thyroid cancer, and it has been reported to deregulate microRNA expression, which is important to thyroid carcinogenesis. Therefore, we have investigated the impact of IR on microRNA expression profile of the normal thyroid cell line (FRTL-5 CL2) and as well as its effect on radiosensitivity of thyroid cancer cell lines, especially the human anaplastic thyroid carcinoma cell line (8505c). METHODS: The global microRNA expression profile of irradiated FRTL-5 CL2 cells (5 Gy X-ray) was characterized and data were confirmed by qRT-PCR evaluating the expression of rno-miR-10b-5p, rno-miR-33-5p, rno-miR-128-1-5p, rno-miR-199a-3p, rno-miR-296-5p, rno-miR-328a-3p and rno-miR-541-5p in irradiated cells...
February 3, 2018: Thyroid: Official Journal of the American Thyroid Association
Joost W van den Berg, Kiki M J M H Lombarts
No abstract text is available yet for this article.
February 2018: Medical Education
George Nikolaidis, Kiki Petroulaki, Foteini Zarokosta, Antonia Tsirigoti, Altin Hazizaj, Enila Cenko, Jelena Brkic-Smigoc, Emir Vajzovic, Vaska Stancheva, Stefka Chincheva, Marina Ajdukovic, Miro Rajter, Marija Raleva, Liljana Trpcevska, Maria Roth, Imola Antal, Veronika Ispanovic, Natasha Hanak, Zeynep Olmezoglu-Sofuoglu, Ismail Umit-Bal, Donata Bianchi, Franziska Meinck, Kevin Browne
Background: Children's exposure to violence is a major public health issue. The Balkan epidemiological study on Child Abuse and Neglect project aimed to collect internationally comparable data on violence exposures in childhood. Methods: A three stage stratified random sample of 42,194 school-attending children (response rate: 66.7%) in three grades (aged 11, 13 and 16 years) was drawn from schools in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Former Yugoslavian Republic of Macedonia (FYROM), Greece, Romania, Serbia and Turkey...
2018: Child and Adolescent Psychiatry and Mental Health
Thomas McKerrell, Naomi Park, Jianxiang Chi, Grace Collord, Thaidy Moreno, Hannes Ponstingl, Joao Dias, Petroula Gerasimou, Kiki Melanthiou, Chrystalla Prokopiou, Marios Antoniades, Ignacio Varela, Paul A Costeas, George S Vassiliou
No abstract text is available yet for this article.
June 13, 2017: Blood Advances
Milou E W M Silkens, Irene A Slootweg, Albert J J A Scherpbier, Maas Jan Heineman, Kiki M J M H Lombarts
INTRODUCTION: High-quality residency training is of utmost importance for residents to become competent medical specialists. Hospital-wide education committees have been adopted by several healthcare systems to govern postgraduate medical education and to support continuous quality improvement of residency training. To understand the functioning and potential of such committees, this study examined the mechanisms through which hospital-wide education committees strive to enable continuous quality improvement in residency training...
December 2017: Perspectives on Medical Education
Milou E W M Silkens, Kiki M J M H Lombarts, Albert J J A Scherpbier, Maas Jan Heineman, Onyebuchi A Arah
BACKGROUND: Postgraduate medical education prepares residents for delivery of high quality patient care during training as well as for later practice, which makes high quality residency training programs crucial to safeguard patient care. Healthy learning climates contribute to high quality postgraduate medical education. In several countries, modernization of postgraduate medical education has resulted in hospital-wide responsibilities for monitoring learning climates. This study investigates the association between the actions undertaken by hospital-wide education committees and learning climates in postgraduate medical education...
December 6, 2017: BMC Medical Education
Myra van den Goor, Milou Silkens, Maas Jan Heineman, Kiki Lombarts
BACKGROUND: Physicians are responsible for delivering high quality of care. In cases of underperformance, hindsight knowledge indicates forewarning being potentially available in terms of concerns, signs, or signals. It is not known how the physicians involved perceive such signals. PURPOSE: To openly explore how physicians perceive soft signals and react on them. METHODS: In-depth interviews with 12 hospital-based physicians from various specialties and institutions following the interpretative phenomenological analysis approach...
November 14, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
Milou E W M Silkens, Saad Chahine, Kiki M J M H Lombarts, Onyebuchi A Arah
INTRODUCTION: The improvement of clinical departments' learning climate is central to achieving high-quality residency training and patient care. However, improving the learning climate can be challenging given its complexity as a multi-dimensional construct. Distinct representations of the dimensions might create different learning climate groups across departments and may require varying efforts to achieve improvement. Therefore, this study investigated: (1) whether distinct learning climate groups could be identified and (2) whether contextual factors could explain variation in departments' learning climate performance...
November 24, 2017: Medical Teacher
Ilhami Kiki
Since the demonstration that hematopoietic cells are present in circulating blood, peripheral blood stem cell transplantation (PBSCT) has become an area of interest. The invention of growth factors such as the granulocyte colony-stimulating factor (G-CSF) and the availability of apheresis techniques allowed the wide application of peripheral blood stem cells (PBSC) in both autologous and allogeneic hematopoietic stem cell transplantation settings. It has been since 1986 that clinically introduced, peripheral blood stem cells replaced bone marrow as a stem-cell source to nearly 100% in the autologous and to approximately 75% in the allogeneic transplantation setting...
November 8, 2017: Transfusion and Apheresis Science
Emre Tekgündüz, Mutlu Arat, Hakan Göker, Hakan Özdoğu, Leylagül Kaynar, Seçkin Çağırgan, Mehmet Ali Erkurt, Filiz Vural, İlhami Kiki, Fevzi Altuntaş, Fatih Demirkan
Autologous hematopoietic cell transplantation (AHCT) is a routinely used procedure in the treatment of adult patients presenting with multiple myeloma (MM), Hodgkin lymphoma (HL) and various subtypes of non-Hodgkin lymphoma (NHL) in upfront and relapsed/refractory settings. Successful hematopoietic progenitor cell mobilization (HPCM) and collection are the rate limiting first steps for application of AHCT. In 2015, almost 1700 AHCT procedures have been performed for MM, HL and NHL in Turkey. Although there are recently published consensus guidelines addressing critical issues regarding autologous HPCM, there is a tremendous heterogeneity in terms of mobilization strategies of transplant centers across the world...
November 10, 2017: Transfusion and Apheresis Science
Emre Tekgündüz, Fatih Demirkan, Filiz Vural, Hakan Göker, Hakan Özdoğu, İlhami Kiki, İsmet Aydoğdu, Leylagül Kaynar, Mehmet Ali Erkurt, Seçkin Çağırgan, Sevgi Beşışık, Simten Dağdaş, Ebru Koca, Gürhan Kadıköylü, Eren Gündüz, Mehmet Yılmaz, Hüseyin Beköz, Ali Uğur Ural, Abdülkadir Baştürk, Mutlu Arat, Murat Albayrak, Erman Öztürk, Alev Akyol, Ali Zahit Bolaman, Oral Nevruz, Hasan Atilla Özkan, Gökhan Özgür, Fevzi Altuntaş
Autologous hematopoietic cell transplantation (AHCT) is an established treatment option for adult patients presenting with multiple myeloma (MM), Hodgkin lymphoma (HL) and various subtypes of non-Hodgkin lymphoma (NHL) in upfront and/or relapsed/refractory disease settings. Although there are recently published consensus guidelines addressing critical issues regarding autologous hematopoietic progenitor cell mobilization (HPCM), mobilization strategies of transplant centers show high variability in terms of routine practice...
November 9, 2017: Transfusion and Apheresis Science
Lieke Tweehuysen, Kiki Schraa, Mihai G Netea, Frank H J van den Hoogen, Leo A B Joosten, Alfons A den Broeder
OBJECTIVES: Clinical data suggest that the response of rheumatoid arthritis patients to treatment with golimumab is much lower among those who switched from adalimumab than among those who switched from etanercept. To elucidate the mechanism behind this difference in response to sequential biologic treatment, we examined the effect of TNF inhibitors on ex vivo cytokine production profiling. METHODS: In a prospective cohort study, blood samples were obtained from patients before the start of a biologic...
October 18, 2017: Clinical and Experimental Rheumatology
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
Kiki Derey, Josef P Rauschecker, Elia Formisano, Giancarlo Valente, Beatrice de Gelder
Meaningful sounds represent the majority of sounds that humans hear and process in everyday life. Yet studies of human sound localization mainly use artificial stimuli such as clicks, pure tones, and noise bursts. The present study investigated the influence of behavioral relevance, sound category, and acoustic properties on the localization of complex, meaningful sounds in the horizontal plane. Participants localized vocalizations and traffic sounds with two levels of behavioral relevance (low and high) within each category, as well as amplitude-modulated tones...
October 2017: Journal of the Acoustical Society of America
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