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https://www.readbyqxmd.com/read/28218984/closing-the-patient-experience-chasm-a-two-level-validation-of-the-consumer-quality-index-inpatient-hospital-care
#1
Alina Smirnova, Kiki M J M H Lombarts, Onyebuchi A Arah, Cees P M van der Vleuten
BACKGROUND: Evaluation of patients' health care experiences is central to measuring patient-centred care. However, different instruments tend to be used at the hospital or departmental level but rarely both, leading to a lack of standardization of patient experience measures. OBJECTIVE: To validate the Consumer Quality Index (CQI) Inpatient Hospital Care for use on both department and hospital levels. DESIGN: Using cross-sectional observational data, we investigated the internal validity of the questionnaire using confirmatory factor analyses (CFA), and the generalizability of the questionnaire for use at the department and hospital levels using generalizability theory...
February 20, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28212117/validation-of-the-incept-a-multisource-feedback-tool-for-capturing-different-perspectives-on-physicians-professional-performance
#2
Mirja W van der Meulen, Benjamin C M Boerebach, Alina Smirnova, Sylvia Heeneman, Mirjam G A Oude Egbrink, Cees P M van der Vleuten, Onyebuchi A Arah, Kiki M J M H Lombarts
INTRODUCTION: Multisource feedback (MSF) instruments are used to and must feasibly provide reliable and valid data on physicians' performance from multiple perspectives. The "INviting Co-workers to Evaluate Physicians Tool" (INCEPT) is a multisource feedback instrument used to evaluate physicians' professional performance as perceived by peers, residents, and coworkers. In this study, we report on the validity, reliability, and feasibility of the INCEPT. METHODS: The performance of 218 physicians was assessed by 597 peers, 344 residents, and 822 coworkers...
February 15, 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28112997/can-a-word-sound-like-a-shape-before-you-have-seen-it-sound-shape-mapping-prior-to-conscious-awareness
#3
Shao-Min Hung, Suzy J Styles, Po-Jang Hsieh
Nonarbitrary mappings between sound and shape (i.e., the bouba-kiki effect) have been shown across different cultures and early in development; however, the level of processing at which this effect arises remains unclear. Here we show that the mapping occurs prior to conscious awareness of the visual stimuli. Under continuous flash suppression, congruent stimuli (e.g., "kiki" inside an angular shape) broke through to conscious awareness faster than incongruent stimuli. This was true even when we trained people to pair unfamiliar letters with auditory word forms, a result showing that the effect was driven by the phonology, not the visual features, of the letters...
January 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28104448/metformin-and-low-dose-radiation-modulates-cisplatin-induced-oxidative-injury-in-rat-via-ppar-%C3%AE-and-mapk-pathways
#4
Heba H Mansour, Shereen M El Kiki, Shereen M Galal
: Cisplatin (CIS) is a chemotherapeutic agent used for therapy of many tumors and has been limited by its toxicity. The aim of this study was to investigate the role of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B(NFkB) in the pathogenesis of hepatic damage induced by CIS, and investigated the modulatory effect of metformin (MET) and/or low dose gamma radiation (LDR) on CIS-induced hepatotoxicity in rats...
January 16, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28084019/is-being-a-medical-educator-a-lonely-business-the-essence-of-social-support
#5
Joost W van den Berg, Christel P M Verberg, Albert J J A Scherpbier, A Debbie C Jaarsma, Kiki M J M H Lombarts
CONTEXT: Social support helps prevent burnout and promotes its positive opposite, work engagement. With higher work engagement performance increases. The context-specific aspects of social support for medical educators, in their educator role, are unknown. To help facilitate social support our study describes the essential elements of social support and their meaning for medical educators. METHODS: We held interviews with medical educators purposefully sampled for diverse backgrounds and working circumstances and who spent a considerable amount of time on education...
January 13, 2017: Medical Education
https://www.readbyqxmd.com/read/28026194/predicting-reading-and-mathematics-from-neural-activity-for-feedback-learning
#6
Sabine Peters, Mara Van der Meulen, Kiki Zanolie, Eveline A Crone
Although many studies use feedback learning paradigms to study the process of learning in laboratory settings, little is known about their relevance for real-world learning settings such as school. In a large developmental sample (N = 228, 8-25 years), we investigated whether performance and neural activity during a feedback learning task predicted reading and mathematics performance 2 years later. The results indicated that feedback learning performance predicted both reading and mathematics performance. Activity during feedback learning in left superior dorsolateral prefrontal cortex (DLPFC) predicted reading performance, whereas activity in presupplementary motor area/anterior cingulate cortex (pre-SMA/ACC) predicted mathematical performance...
January 2017: Developmental Psychology
https://www.readbyqxmd.com/read/27900673/expansion-of-the-phenotypic-spectrum-of-propionic-acidemia-with-isolated-elevated-propionylcarnitine
#7
Gerarda Cappuccio, Paldeep S Atwal, Taraka R Donti, Kiki Ugarte, Nadia Merchant, William J Craigen, V Reid Sutton, Sarah H Elsea
We report three patients with elevations of propionylcarnitine (C3), one without elevations of 2-methylcitrate and 3-hydroxypropionate in urine organic acid analysis, and the other two showing only mild elevations, all of whom were subsequently confirmed to have propionic acidemia by molecular analysis of PCCA and PCCB genes. To date, they have had a mild clinical course. These cases illustrate the importance of considering high C3 as the only biochemical abnormality in a diagnosis of propionic acidemia. Since mild C3 elevations may be overlooked and considered non-diagnostic in isolation, we advise considering a diagnosis of propionic acidemia even in the absence of significant elevations 2-methylcitrate or 3-hydroxypropionate in urine organic acid analysis...
November 30, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27815858/a-retrospective-study-of-azacitidine-treatment-in-patients-with-intermediate-2-or-high-risk-myelodysplastic-syndromes-in-a-real-world-clinical-setting-in-greece
#8
Vasiliki Pappa, Achilles Anagnostopoulos, Eleni Bouronikou, Evangelos Briasoulis, Ioannis Kotsianidis, Maria Pagoni, Panagiotis Zikos, Konstantinos Tsionos, Nora Viniou, John Meletis, Helen Papadaki, Anna Kioumi, Athanasios Galanopoulos, Elisavet-Christine Vervessou, Elias Poulakidas, Panagiotis Karmas, Kiki Karvounis, Argiris Symeonidis
For patients with intermediate-2 or high risk [according to the International Prognostic Scoring System (IPSS)] myelodysplastic syndromes (MDS), azacitidine treatment offers hematologic improvement (HI) but also has the potential to modify the natural disease course. 'RETRO-AZA-MDS-001', a retrospective chart review study was conducted from February to November 2012 across 17 hematology hospital sites of Greece, aiming to evaluate the clinical efficacy and safety profile of azacitidine in IPSS intermediate-2/high risk adult MDS patients in routine care...
November 4, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27809888/the-struggle-by-caenorhabditis-elegans-to-maintain-proteostasis-during-aging-and-disease
#9
REVIEW
Elise A Kikis
: The presence of only small amounts of misfolded protein is an indication of a healthy proteome. Maintaining proteome health, or more specifically, "proteostasis," is the purview of the "proteostasis network." This network must respond to constant fluctuations in the amount of destabilized proteins caused by errors in protein synthesis and exposure to acute proteotoxic conditions. Aging is associated with a gradual increase in damaged and misfolded protein, which places additional stress on the machinery of the proteostasis network...
November 3, 2016: Biology Direct
https://www.readbyqxmd.com/read/27790212/the-influence-of-sporulation-conditions-on-the-spore-coat-protein-composition-of-bacillus-subtilis-spores
#10
Wishwas R Abhyankar, Kiki Kamphorst, Bhagyashree N Swarge, Henk van Veen, Nicole N van der Wel, Stanley Brul, Chris G de Koster, Leo J de Koning
Spores are of high interest to the food and health sectors because of their extreme resistance to harsh conditions, especially against heat. Earlier research has shown that spores prepared on solid agar plates have a higher heat resistance than those prepared under a liquid medium condition. It has also been shown that the more mature a spore is, the higher is its heat resistance most likely mediated, at least in part, by the progressive cross-linking of coat proteins. The current study for the first time assesses, at the proteomic level, the effect of two commonly used sporulation conditions on spore protein presence...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27768380/inhibited-temperament-and-hippocampal-volume-in-offspring-of-parents-with-bipolar-disorder
#11
Eunjoo Kim, Amy Garrett, Spencer Boucher, Min-Hyeon Park, Meghan Howe, Erica Sanders, Ryan G Kelley, Allan L Reiss, Kiki D Chang, Manpreet K Singh
BACKGROUND: Prior studies have suggested that inhibited temperament may be associated with an increased risk for developing anxiety or mood disorder, including bipolar disorder. However, the neurobiological basis for this increased risk is unknown. The aim of this study was to examine temperament in symptomatic and asymptomatic child offspring of parents with bipolar disorder (OBD) and to investigate whether inhibited temperament is associated with aberrant hippocampal volumes compared with healthy control (HC) youth...
October 21, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27714409/filamentous-actin-accumulates-during-plant-cell-penetration-and-cell-wall-plug-formation-in-phytophthora-infestans
#12
Kiki Kots, Harold J G Meijer, Klaas Bouwmeester, Francine Govers, Tijs Ketelaar
The oomycete Phytophthora infestans is the cause of late blight in potato and tomato. It is a devastating pathogen and there is an urgent need to design alternative strategies to control the disease. To find novel potential drug targets, we used Lifeact-eGFP expressing P. infestans for high resolution live cell imaging of the actin cytoskeleton in various developmental stages. Previously, we identified actin plaques as structures that are unique for oomycetes. Here we describe two additional novel actin configurations; one associated with plug deposition in germ tubes and the other with appressoria, infection structures formed prior to host cell penetration...
October 6, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27680030/gonadal-function-in-boys-with-newly-diagnosed-cancer-before-the-start-of-treatment
#13
Kiki M G J Wigny, Wendy van Dorp, Anne-Lotte L F van der Kooi, Yolanda B de Rijke, Andrica C H de Vries, Marij Smit, Saskia M F Pluijm, Erica L T van den Akker, Rob Pieters, Joop S E Laven, Marry M van den Heuvel-Eibrink
STUDY QUESTION: Are Inhibin B and testosterone levels reduced in boys with newly diagnosed cancer prior to therapy? SUMMARY ANSWER: Pretreatment serum levels of Inhibin B and testosterone are significantly reduced in boys with newly diagnosed cancer, compared to reference values. WHAT IS ALREADY KNOWN: Disease-related gonadal impairment has been demonstrated in girls and young women diagnosed with cancer, prior to therapy. STUDY DESIGN, SIZE, DURATION: We conducted a descriptive study in boys newly diagnosed with cancer between January 2006 and February 2014...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27642224/surface-tensions-of-ionic-liquids-non-regular-trend-along-the-number-of-cyano-groups
#14
Hugo F D Almeida, Pedro J Carvalho, Kiki A Kurnia, José A Lopes-da-Silva, João A P Coutinho, Mara G Freire
Ionic liquids (ILs) with cyano-functionalized anions are a set of fluids that are still poorly characterized despite their remarkably low viscosities and potential applications. Aiming at providing a comprehensive study on the influence of the number of -CN groups through the surface tension and surface organization of ILs, the surface tensions of imidazolium-based ILs with cyano-functionalized anions were determined at atmospheric pressure and in the (298.15 to 343.15) K temperature range. The ILs investigated are based on 1-alkyl-3-methylimidazolium cations (alkyl = ethyl, butyl and hexyl) combined with the [SCN](-), [N(CN)2](-), [C(CN)3](-) and [B(CN)4](-)anions...
February 15, 2016: Fluid Phase Equilibria
https://www.readbyqxmd.com/read/27642223/densities-viscosities-and-derived-thermophysical-properties-of-water-saturated-imidazolium-based-ionic-liquids
#15
Mónia A R Martins, Catarina M S S Neves, Kiki A Kurnia, Pedro J Carvalho, Marisa A A Rocha, Luís M N B F Santos, Simão P Pinho, Mara G Freire
In order to evaluate the impact of the alkyl side chain length and symmetry of the cation on the thermophysical properties of water-saturated ionic liquids (ILs), densities and viscosities as a function of temperature were measured at atmospheric pressure and in the (298.15 to 363.15) K temperature range, for systems containing two series of bis(trifluoromethylsulfonyl)imide-based compounds: the symmetric [C n C n im][NTf2] (with n = 1-8 and 10) and asymmetric [C n C1im][NTf2] (with n = 2-5, 7, 9 and 11) ILs...
January 15, 2016: Fluid Phase Equilibria
https://www.readbyqxmd.com/read/27611104/prospective-controlled-study-of-gastroesophageal-reflux-in-dogs-with-naturally-occurring-laryngeal-paralysis
#16
Kiki M Tarvin, David C Twedt, Eric Monnet
OBJECTIVE: To determine the frequency, nature, and magnitude of gastroesophageal reflux (GER) in dogs with laryngeal paralysis (LP). STUDY DESIGN: Prospective comparative clinical study. ANIMALS: Client-owned dogs with LP and healthy client-owned dogs (n = 6 each). METHODS: Dogs underwent sedated laryngeal examination for diagnosis and grading of bilateral LP and for placement of a nasoesophageal dual pH/impedance probe...
October 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27606931/redesign-of-the-system-for-evaluation-of-teaching-qualities-in-anesthesiology-residency-training-setq-smart
#17
Kiki M J M H Lombarts, Andrew Ferguson, Markus W Hollmann, Bente Malling, Onyebuchi A Arah
BACKGROUND: Given the increasing international recognition of clinical teaching as a competency and regulation of residency training, evaluation of anesthesiology faculty teaching is needed. The System for Evaluating Teaching Qualities (SETQ) Smart questionnaires were developed for assessing teaching performance of faculty in residency training programs in different countries. This study investigated (1) the structure, (2) the psychometric qualities of the new tools, and (3) the number of residents' evaluations needed per anesthesiology faculty to use the instruments reliably...
November 2016: Anesthesiology
https://www.readbyqxmd.com/read/27589038/knowledge-gaps-in-patients-with-atrial-fibrillation-revealed-by-a-new-validated-knowledge-questionnaire
#18
Lien Desteghe, Lara Engelhard, Zina Raymaekers, Kiki Kluts, Johan Vijgen, Dagmara Dilling-Boer, Pieter Koopman, Joris Schurmans, Paul Dendale, Hein Heidbuchel
OBJECTIVE: The aim of this study was to develop and validate a new questionnaire, the Jessa Atrial fibrillation Knowledge Questionnaire (JAKQ), to test the knowledge of patients with atrial fibrillation (AF) about the arrhythmia, its treatment and their ability for self-management. METHODS: The JAKQ was developed based on other questionnaires, two educational checklists and patient information support websites. The JAKQ was validated based on content validity, face validity, response process, discriminatory potential and sensitivity of the questionnaire, construct validity and reliability...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27570929/pediatric-bipolar-disorder-combination-pharmacotherapy-adverse-effects-and-treatment-of-high-risk-youth
#19
Kiki D Chang
Treating bipolar disorder in pediatric patients is challenging because data from rigorous trials of pharmacotherapy in this population are still not plentiful enough. Furthermore, the treatment of children and adolescents is complicated by the frequent need to combine pharmacotherapies to address all bipolar symptoms as well as this population's elevated risk for experiencing side effects. Additionally, young patients with depressive episodes who are at high risk for developing bipolar disorder need careful treatment to prevent or delay the emergence of mania...
2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27493268/in-vivo-imaging-of-antileukemic-drug-asparaginase-reveals-a-rapid-macrophage-mediated-clearance-from-the-bone-marrow
#20
Laurens T van der Meer, Samantha Y A Terry, Dorette van Ingen Schenau, Kiki C Andree, Gerben M Franssen, Debbie M Roeleveld, Bart M Metselaar, Thomas Reinheckel, Peter M Hoogerbrugge, Otto C Boerman, Frank N van Leeuwen
: The antileukemic drug asparaginase, a key component in the treatment of acute lymphoblastic leukemia, acts by depleting asparagine from the blood. However, little is known about its pharmacokinetics and mechanisms of therapy resistance are poorly understood. Here, we explored the in vivo biodistribution of radiolabeled asparaginase, using a combination of in vivo imaging and biochemical techniques, and provide evidence for tissue specific clearance mechanisms, which could reduce effectiveness of the drug at these specific sites...
August 4, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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