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https://www.readbyqxmd.com/read/30006930/towards-a-real-liquid-biopsy-in-metastatic-breast-and-prostate-cancer-diagnostic-leukapheresis-increases-ctc-yields-in-a-european-prospective-multi-center-study-ctctrap
#1
Kiki C Andree, Anouk Mentink, Leonie L Zeune, Leon W M M Terstappen, Nikolas H Stoecklein, Rui P Neves, Christiane Driemel, Rita Lampignano, Liwen Yang, Hans Neubauer, Tanja Fehm, Johannes C Fischer, Elisabetta Rossi, Mariangela Manicone, Umberto Basso, Piero Marson, Rita Zamarchi, Yohann Loriot, Valerie Lapierre, Vincent Faugeroux, Marianne Oulhen, Françoise Farace, Gemma Fowler, Mariane Sousa Fontes, Berni Ebbs, Maryou Lambros, Mateus Crespo, Penny Flohr, Johann S de Bono
Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a 'liquid biopsy'. In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen liters of blood. Here we present the results obtained from 34 metastatic cancer patients subjected to DLA in the participating institutions. 7.5 mL blood processed with CellSearch was used as 'gold standard' reference...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29982038/bouba-or-kiki-with-and-without-vision-shape-audio-regularities-and-mental-images
#2
Torø Graven, Clea Desebrock
95% of the world's population associate a rounded visual shape with the spoken word 'bouba', and an angular visual shape with the spoken word 'kiki', known as the bouba/kiki-effect. The bouba/kiki-effect occurs irrespective of familiarity with either the shape or word. This study investigated the bouba/kiki-effect when using haptic touch instead of vision, including the role of visual imagery. It also investigated whether the bouba/kiki shape-audio regularities are noticed at all, that is, whether they affect the bouba/kiki-effect itself and/or the recognition of individual bouba/kiki shapes, and finally what mental images they produce...
July 5, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29954982/the-cost-of-a-career
#3
Elise A Kikis
No abstract text is available yet for this article.
June 29, 2018: Science
https://www.readbyqxmd.com/read/29909357/abdominal-muscle-recruitment-and-its-effect-on-the-activity-level-of-the-hip-and-posterior-thigh-muscles-during-therapeutic-exercises-of-the-hip-joint
#4
Sharon M H Tsang, Amanda H M Lam, Melody H L Ng, Kiki W K Ng, Cherry O H Tsui, Benjamin Yiu
Abdominal exercise has been advocated to improve the protection of the spine and neuromuscular efficiency of the limb movements. The purpose of this study was to examine the effect of enhanced contraction of internal oblique and transversus abdominis (IO/TrA) on the activity level of the hip and posterior thigh muscles during therapeutic hip exercises. Twenty healthy females were required to perform eight hip exercises under two conditions, natural versus enhanced IO/TrA contraction conditions. Muscle activity of gluteus maximus, gluteus medius, tensor fasciae latae and biceps femoris of the exercising leg was measured by surface electromyography during hip exercises, and expressed in percentage normalized to the maximal voluntary isometric contraction (%MVIC)...
June 12, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29847157/neurofunctional-correlates-of-response-to-quetiapine-in-adolescents-with-bipolar-depression
#5
Kiki Chang, Melissa DelBello, Amy Garrett, Ryan Kelley, Meghan Howe, Cal Adler, Jeffrey Welge, Stephen M Strakowski, Manpreet Singh
OBJECTIVES: Prior studies have shown that youth with bipolar disorder demonstrate neurofunctional changes in key prefrontal and subcortical brain regions implicated in emotional regulation following treatment with pharmacological agents. We recently reported a large response rate (>60%) to quetiapine (QUET) for treating depressive symptoms in adolescents with bipolar depression. This study investigates the neurofunctional effects of QUET using functional magnetic resonance imaging (fMRI)...
May 30, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29846880/the-uptake-of-presymptomatic-genetic-testing-in-hereditary-breast-ovarian-cancer-and-lynch-syndrome-a-systematic-review-of-the-literature-and-implications-for-clinical-practice
#6
REVIEW
Fred H Menko, Jacqueline A Ter Stege, Lizet E van der Kolk, Kiki N Jeanson, Winnie Schats, Daoud Ait Moha, Eveline M A Bleiker
Following the identification in a proband of a germline BRCA1/BRCA2 mutation in hereditary breast-ovarian cancer (HBOC) or a DNA mismatch repair gene mutation in Lynch syndrome (LS) he or she will be asked to inform at-risk family members about the option for presymptomatic DNA testing. However, in clinical practice multiple factors may complicate the process of information sharing. We critically evaluated studies on the uptake of presymptomatic genetic testing in both syndromes. A search of relevant MeSH terms and key words in PubMed, Embase and PsycINFO yielded 795 articles published between 2001 and 2017...
May 30, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29771691/the-relationship-between-the-learning-and-patient-safety-climates-of-clinical-departments-and-residents-patient-safety-behaviors
#7
Milou E W M Silkens, Onyebuchi A Arah, Cordula Wagner, Albert J J A Scherpbier, Maas Jan Heineman, Kiki M J M H Lombarts
PURPOSE: Improving residents' patient safety behavior should be a priority in graduate medical education to ensure the safety of current and future patients. Supportive learning and patient safety climates may foster this behavior. This study examined the extent to which residents' self-reported patient safety behavior can be explained by the learning climate and patient safety climate of their clinical departments. METHOD: The authors collected learning climate data from clinical departments in the Netherlands that used the web-based Dutch Residency Educational Climate Test between September 2015 and October 2016...
May 15, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29770748/the-effect-of-switching-protease-inhibitors-to-raltegravir-on-endothelial-function-in-hiv-infected-patients
#8
Maaike Krikke, Kiki Tesselaar, Guido E L van den Berk, Sigrid A Otto, Laura H Freriks, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman, Joop E Arends
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has a relatively favorable effect on plasma lipids. We examined the effect of switching from PIs to RAL on endothelial function, and its effect on immunological and inflammatory parameters. Methods We performed a 16-week open-label prospective crossover study: 8 weeks intervention (switch PIs to RAL) and 8 weeks control (unchanged cART regimen)...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29759958/data-access-and-usage-practices-across-a-cohort-of-researchers-at-a-large-tertiary-pediatric-hospital-qualitative-survey-study
#9
Hoi Ki Kiki Ho, Matthias Görges, Elodie Portales-Casamar
BACKGROUND: Health and health-related data collected as part of clinical care is a foundational component of quality improvement and research. While the importance of these data is widely recognized, there are many challenges faced by researchers attempting to use such data. It is crucial to acknowledge and identify barriers to improve data sharing and access practices and ultimately optimize research capacity. OBJECTIVE: To better understand the current state, explore opportunities, and identify barriers, an environmental scan of investigators at BC Children's Hospital Research Institute (BCCHR) was conducted to elucidate current local practices around data access and usage...
May 14, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29747630/reflection-revisited-how-physicians-conceptualize-and-experience-reflection-in-professional-practice-a-qualitative-study
#10
Elisa Bindels, Christel Verberg, Albert Scherpbier, Sylvia Heeneman, Kiki Lombarts
BACKGROUND: For the purpose of continuous performance improvement, physicians are expected to reflect on their practice. While many reflection studies are theoretically oriented and often prescriptive in the sense that they conceptualize what reflection should look like, the current study starts with practicing physicians themselves and maps how these physicians conceptualize and experience reflection in daily professional practice. METHODS: We conducted a qualitative study using in-depth interviews with 13 hospital-based physicians from various specialties and institutions...
May 11, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29718601/diagnosing-bipolar-disorder-in-pediatric-patients
#11
Kiki D Chang
As many as 2 million youths in the US alone could have bipolar disorder. In this CME brief report, get up-to-date on common presentations of pediatric bipolar disorder, DSM-5 diagnostic criteria, and structured interviews and screening tools that can help you detect manic symptomatology.
March 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29717574/efficacy-and-tolerability-of-artesunate-amodiaquine-versus-artemether-lumefantrine-in-the-treatment-of-uncomplicated-plasmodium-falciparum-malaria-at-two-sentinel-sites-across-c%C3%A3-te-d%C3%A2-ivore
#12
Abibatou Konaté, Pulchérie Christiane Marie Barro-Kiki, Kpongbo Etienne Angora, Akoua Valérie Bédia-Tanoh, Vincent Djohan, Kondo Fulgence Kassi, Henriette Vanga-Bosson, Assohoun Jean Sébastien Miézan, Serge Brice Assi, Eby Ignace Hervé Menan, William Yavo
Malaria remains a major public health problem in Côte d’Ivoire. The aim of this study is to compare the efficacy and tolerability of artesunate-amodiaquine (ASAQ) versus artemether-lumefantrine (AL) for the treatment of uncomplicated malaria, at two malaria surveillance sites in Côte d’Ivoire. The World Health Organization 2003 protocol was used for this multicenter open randomized clinical trial with a 42-day follow-up. We recruited 240 patients (120 per arm), of whom 114 (ASAQ group) and 112 (AL group) were fully followed-up...
2018: Annals of Parasitology
https://www.readbyqxmd.com/read/29705017/treatment-satisfaction-of-patients-with-advanced-non-small-cell-lung-cancer-receiving-platinum-based-chemotherapy-results-from-a-prospective-cohort-study-personal
#13
Sabine Visser, Mark de Mol, Kiki Cheung, Jermo J van Toor, Nico C van Walree, Bruno H Stricker, Brenda L Den Oudsten, Joachim G J V Aerts
INTRODUCTION: In patients with advanced non-small-cell lung cancer, the treatment benefits and risks need to be constantly weighed. We explored patient-reported satisfaction with therapy (SWT) and assessed its value in addition to quality of life (QoL) and adverse events (AEs). PATIENTS AND METHODS: In a prospective multicenter cohort study, patients with stage IIIB/IV non-small-cell lung cancer received platinum-pemetrexed chemotherapy. They completed the World Health Organization Quality of Life-BREF (WHOQoL-BREF) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) before and during chemotherapy...
March 17, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29686754/comprehensive-revenue-and-expense-data-collection-methodology-for-teaching-health-centers-a-model-for-accountable-graduate-medical-education-financing
#14
Marsha Regenstein, John E Snyder, Mariellen Malloy Jewers, Kiki Nocella, Fitzhugh Mullan
Background : Despite considerable federal investment, graduate medical education financing is neither transparent for estimating residency training costs nor accountable for effectively producing a physician workforce that matches the nation's health care needs. The Teaching Health Center Graduate Medical Education (THCGME) program's authorization in 2010 provided an opportunity to establish a more transparent financing mechanism. Objective : We developed a standardized methodology for quantifying the necessary investment to train primary care physicians in high-need communities...
April 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29685075/synergistic-effect-of-cranberry-extract-and-losartan-against-aluminium-chloride-induced-hepatorenal-damage-associated-cardiomyopathy-in-rats
#15
Shereen Mohamed Galal, Hesham Farouk Hasan, Mohamed Khairy Abdel-Rafei, Shereen Mohamed El Kiki
The present study was designed to evaluate the effect of cranberry extract (CRAN) and/or losartan (LOS) against aluminium chloride (AlCl3 ) induced hepatorenal damage associated cardiomyopathy in rats. To induce hepatorenal and cardiotoxicity, animals were received (AlCl3 ; 70 mg/kg i.p.) for 8 weeks day after day and treated with CRAN (100 mg/kg b.wt.) orally daily for 4 weeks started after 4 weeks from AlCl3 injection accompanied with an administration of LOS (5 mg/kg i.p.) three times weekly for 4 weeks...
April 23, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29659209/improving-the-diagnosis-and-treatment-of-pediatric-bipolar-disorder
#16
Robert L Findling, Kiki D Chang
​​Reconsidering Insomnia as a Disorder Rather Than Just a Symptom in Psychiatric Practice Click to enlarge page Awareness of the prevalence and impact of bipolar disorder in pediatric patients has grown in recent years. Youths with this disorder are at risk for poor long-term outcomes, but with careful screening, clinicians may be able to detect early signs or subthreshold symptoms and provide a timely diagnosis and effective treatment. Although several pharmacologic options are available for patients aged 10 years and up, they differ in their safety and tolerability profiles...
March 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29624729/kiki-net-cross-domain-convolutional-neural-networks-for-reconstructing-undersampled-magnetic-resonance-images
#17
Taejoon Eo, Yohan Jun, Taeseong Kim, Jinseong Jang, Ho-Joon Lee, Dosik Hwang
PURPOSE: To demonstrate accurate MR image reconstruction from undersampled k-space data using cross-domain convolutional neural networks (CNNs) METHODS: Cross-domain CNNs consist of 3 components: (1) a deep CNN operating on the k-space (KCNN), (2) a deep CNN operating on an image domain (ICNN), and (3) an interleaved data consistency operations. These components are alternately applied, and each CNN is trained to minimize the loss between the reconstructed and corresponding fully sampled k-spaces...
April 6, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29619913/emergency-department-boarding-a-descriptive-analysis-and-measurement-of-impact-on-outcomes
#18
Leila Salehi, Prashant Phalpher, Rahim Valani, Christopher Meaney, Qamar Amin, Kiki Ferrari, Mathew Mercuri
CLINICIAN'S CAPSULE What is known about the topic? Bed boarding is one of the major contributors to emergency department overcrowding. What did this study ask? What are the characteristics of patients with prolonged boarding times, and what are the impacts on patient-oriented outcomes? What did this study find? Patients who were older, sicker, and had isolation and telemetry requirements experienced longer boarding times, and longer inpatient length of stay even after correcting for confounders. Why does this study matter to clinicians? Organization-wide interventions to improve efficiency and flow are required to mitigate the burden of bed boarding...
April 5, 2018: CJEM
https://www.readbyqxmd.com/read/29619031/impact-of-aging-cytomegalovirus-infection-and-long-term-treatment-for-human-immunodeficiency-virus-on-cd8-t-cell-subsets
#19
Ellen Veel, Liset Westera, Rogier van Gent, Louis Bont, Sigrid Otto, Bram Ruijsink, Huib H Rabouw, Tania Mudrikova, Annemarie Wensing, Andy I M Hoepelman, José A M Borghans, Kiki Tesselaar
Both healthy aging and human immunodeficiency virus (HIV) infection lead to a progressive decline in naive CD8+ T-cell numbers and expansion of the CD8+ T-cell memory and effector compartments. HIV infection is therefore often considered a condition of premature aging. Total CD8+ T-cell numbers of HIV-infected individuals typically stay increased even after long-term (LT) combination antiretroviral treatment (cART), which is associated with an increased risk of non-AIDS morbidity and mortality. The causes of these persistent changes in the CD8+ T-cell pool remain debated...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29606183/desperately-seeking-outcomes-quantifying-the-effectiveness-of-community-mental-healthcare-using-health-of-the-nation-outcome-scales
#20
Richard Laugharne, Scott Eaves, Alin Mascas, Kiki Psatha, Gill Dinnis, Jonathan Trower, Rohit Shankar
BACKGROUND: Community mental health services in the UK have struggled to measure the clinical effectiveness of their services.AimsTo measure clinical outcomes for different diagnostic clusters. METHOD: Clinicians measure the clinical status of patients by the Health of the Nation Outcome Scales (HoNOS), and HoNOS scores should be recorded annually after treatment. Clinical outcomes were measured by changes in HoNOS for diagnostic clusters. RESULTS: In two time periods (2014 and 2016), the health of patients with mild to moderate common mental disorders deteriorated after intervention...
May 2018: BJPsych Open
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