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https://www.readbyqxmd.com/read/29035676/the-molecular-mechanism-and-neuroprotective-effect-of-dihydrocapsaicin-induced-mild-hypothermia-after-cardiopulmonary-resuscitation-in-rats
#1
Xiaopeng Zhong, Xiujuan Wang, Fei Fei, ManCui Zhang, Po Ding, Shiwu Zhang
To investigate the molecular mechanism of dihydrocapsaicin (DHC)-induced mild hypothermia in rats, and to compare its protective effect on the central nervous system with that of a conventional method of inducing hypothermia, 24 healthy male Sprague Dawley rats were randomly divided into four groups based on the following conditions: control group, cardiopulmonary resuscitation (CPR) group, body surface cooling group, and DHC group. Tracheal clipping was used to mimic asphyxia arrest. Rats were assessed for their neurological deficit scores...
October 16, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29032323/neural-activity-during-traumatic-film-viewing-is-linked-to-endogenous-estradiol-and-hormonal-contraception
#2
Stephan F Miedl, Melanie Wegerer, Hubert Kerschbaum, Jens Blechert, Frank H Wilhelm
Women are at higher risk for Posttraumatic Stress Disorder (PTSD) and recent research has highlighted a modulating role of female sex hormones for cognitive and emotional processes potentially underlying PTSD symptoms. However, studies combining fMRI recordings of brain activity during trauma film viewing with assessment of female sex hormones are missing. The trauma film paradigm - a widely used experimental analogue for trauma exposure - confronts healthy participants with traumatic film clips and thus allows studying peritraumatic processing under laboratory conditions...
October 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29032217/preoperative-prediction-of-the-necessity-for-anterior-clinoidectomy-during-microsurgical-clipping-of-ruptured-posterior-communicating-artery-aneurysms
#3
Tomoya Kamide, Jan-Karl Burkhardt, Halima Tabani, Michael Safaee, Michael T Lawton
BACKGROUND: Although most posterior communicating artery (PCoA) aneurysms can be clipped easily with excellent results, some require anterior clinoidectomy for safe and complete clipping. OBJECTIVE: To review our microsurgical series of ruptured PCoA aneurysms and identify the preoperative predictors for anterior clinoidectomy during microsurgical clipping for PCoA aneurysms METHODS: Results from microsurgical clipping of 104 patients with ruptured PCoA aneurysms were retrospectively reviewed...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29031931/global-analysis-of-ago2-bound-rnas-reveals-that-mirnas-induce-cleavage-of-target-rnas-with-limited-complementarity
#4
Eunsun Jung, Youngmo Seong, Bohyun Jeon, Hoseok Song, Young-Soo Kwon
Among the four Argonaute family members in mammals, only AGO2 protein retains endonuclease activity and facilitates cleavage of target RNAs base-pairing with highly complementary guide RNAs. Despite the deeply conserved catalytic activity, only a small number of targets have been reported to extensively base pair with cognate miRNAs to be cleaved by AGO2. Here, we analyzed AGO2-bound RNAs by CrossLinking ImmunoPrecipitation (CLIP) of genetically modified cells that express epitope-tagged AGO2 from the native genomic locus...
October 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#5
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29030843/cclip-seq-retrieval-of-chimeric-reads-from-hits-clip-clip-seq-libraries
#6
Panagiotis Alexiou, Manolis Maragkakis, Zissimos Mourelatos, Anastassios Vourekas
HITS-CLIP (High-Throughput Sequencing after in vivo Crosslinking and Immunoprecipitation, CLIP-Seq) libraries contain fragments of the RNA sequences bound in vivo by an RNA binding protein (RBP). Such fragments, especially if they represent RNA duplexes bound in vivo by the RBP, can occasionally be ligated together to form chimeric CLIP tags. Chimeric CLIP tags from Argonaute CLIP libraries can provide the exact base pairing profiles of small RNAs with their target RNA sequences, thus solving a critical problem in the field of post-transcriptional regulation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29030789/foreign-bodies-in-sigmoid-colon-diverticulosis
#7
REVIEW
Ellen Ross, Patricia McKenna, John H Anderson
This review addresses the management of sigmoid colon diverticular disease associated with foreign bodies. In addition, two novel cases are presented. One case describes the management of diverticular bleeding secondary to a chicken bone and the other case reports retrieval of a retained EndoRings™ Device. The review identified 40 relevant publications including 50 subjects. Foreign bodies within sigmoid diverticular disease may be associated with inflammation, perforation, abscess and fistula. In current practice, diagnosis is often achieved with CT scan...
October 13, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29029292/minimizing-retraction-by-pia-arachnoidal-10-0-sutures-in-intrasulcal-dissection
#8
Kutluay Uluc, Ulas Cikla, Deniz B Morkan, Alperen Sirin, Azam S Ahmed, Kyle Swanson, Mustafa K Baskaya
BACKGROUND: In contemporary microneurosurgery reducing retraction-induced injury to the brain is essential. Self-retaining retractor systems are commonly used to improve visualization and decrease the repetitive microtrauma, but sometimes self-retaining retractor systems can be cumbersome and the force applied can cause focal ischemia or contusions. This may increase the morbidity and mortality. Here, we describe a technique of retraction using 10-0 sutures in the arachnoid. OBJECTIVE: To evaluate the imaging and clinical results in patients where 10-0 suture retraction was used to aid the surgical procedure...
September 19, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29029288/microsurgical-clipping-of-a-blister-like-basilar-tip-aneurysm-2-dimensional-operative-video
#9
Rami O Almefty, Robert F Spetzler
No abstract text is available yet for this article.
September 22, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29029197/microsurgical-clip-reconstruction-of-a-1-cm-complex-anterior-communicating-artery-aneurysm-via-an-orbitozygomatic-approach-2-dimensional-operative-video
#10
Gary Rajah, Richard Justin Garling, Murali Guthikonda, Leonardo Rangel-Castilla
No abstract text is available yet for this article.
September 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29029039/the-effects-of-audiovisual-inputs-on-solving-the-cocktail-party-problem-in-the-human-brain-an-fmri-study
#11
Yuanqing Li, Fangyi Wang, Yongbin Chen, Andrzej Cichocki, Terrence Sejnowski
At cocktail parties, our brains often simultaneously receive visual and auditory information. Although the cocktail party problem has been widely investigated under auditory-only settings, the effects of audiovisual inputs have not. This study explored the effects of audiovisual inputs in a simulated cocktail party. In our fMRI experiment, each congruent audiovisual stimulus was a synthesis of 2 facial movie clips, each of which could be classified into 1 of 2 emotion categories (crying and laughing). Visual-only (faces) and auditory-only stimuli (voices) were created by extracting the visual and auditory contents from the synthesized audiovisual stimuli...
September 25, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29028411/expanding-the-map-of-protein-rna-interaction-sites-via-cell-fusion-followed-by-par-clip
#12
Florian Hinze, Philipp Drewe-Boß, Miha Milek, Uwe Ohler, Markus Landthaler, Michael Gotthardt
PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation) facilitates the identification and mapping of protein/RNA interactions. So far, it has been limited to select cell-lines as it requires efficient 4SU uptake. To increase transcriptome complexity and thus identify additional RNA-protein interaction sites we fused HEK 293 T-Rex cells (HEK293-Y) that express the RNA binding protein YBX1 with PC12 cells expressing eGFP (PC12-eGFP). The resulting hybrids enable PAR-CLIP on a neuronally expanded transcriptome (Fusion-CLIP) and serve as a proof of principle...
October 13, 2017: RNA Biology
https://www.readbyqxmd.com/read/29027862/effect-of-body-mass-index-on-outcome-after-aneurysmal-subarachnoid-hemorrhage-treated-with-clipping-versus-coiling
#13
Lorenzo Rinaldo, Joshua D Hughes, Alejandro A Rabinstein, Giuseppe Lanzino
OBJECTIVE It has been suggested that increased body mass index (BMI) may confer a protective effect on patients who suffer from aneurysmal subarachnoid hemorrhage (aSAH). Whether the modality of aneurysm occlusion influences the effect of BMI on patient outcomes is not well understood. The authors aimed to compare the effect of BMI on outcomes for patients with aSAH treated with surgical clipping versus endovascular coiling. METHODS The authors retrospectively reviewed the outcomes for patients admitted to their institution for the management of aSAH treated with either clipping or coiling...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027776/lung-ultrasonography-and-echocardiography-in-the-icu-a-combined-and-practical-approach
#14
Antoine Vieillard-Baron, Paul Mayo
This article describes some practical applications of critical care ultrasonography that are of interest to the frontline intensivist. Instead of presenting a standard state of the art review article, we present 3 typical clinical cases where combined echocardiography, lung ultrasonography, and other ultrasonography techniques were helpful to the critical care team. The manuscript includes a variety figures and video clips that illustrate the utility of critical care ultrasonography in guiding diagnosis and management of the critically ill patient...
October 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29026674/chronic-headache-caused-by-a-titanium-fixation-plate-report-of-two-cases
#15
Shigeomi Yokoya, Akihiko Hino, Hideki Oka
BACKGROUND: We report two patients with chronic postcraniotomy headache who showed rapid alleviation of pain after removal of titanium miniplates. CASE DESCRIPTION: (Case 1) A 26-year-old woman underwent a right frontal craniotomy and excision of the entire cerebral cavernous malformation. Eleven years later, she developed headache. The titanium plate was removed and the patient presented complete amelioration of headache. (Case 2) A 50-year-old man underwent an aneurysm clipping via the lateral supraorbital approach of the left side...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026600/effect-of-prophylactic-clipping-in-colorectal-endoscopic-resection-a-meta-analysis-of-randomized-controlled-studies
#16
REVIEW
Toshihiro Nishizawa, Hidekazu Suzuki, Osamu Goto, Haruhiko Ogata, Takanori Kanai, Naohisa Yahagi
BACKGROUND AND AIM: The efficacy of clipping for preventing delayed bleeding after colorectal endoscopic resection is still controversial. To assess the efficacy of prophylactic clipping, we conducted a meta-analysis of randomized controlled trials. METHODS: We searched PubMed, the Cochrane library, and the Igaku-chuo-zasshi database for randomized trials eligible for inclusion in our meta-analysis. We identified seven eligible randomized trials from the database search, and compared the effect of clipping versus non-clipping with respect to delayed bleeding and perforation...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29025963/sacral-dural-arteriovenous-fistulas-a-diagnostic-and-therapeutic-challenge-single-centre-experience-of-13-cases-and-review-of-the-literature
#17
Andrea Gioppo, Giuseppe Faragò, Caterina Giannitto, Luigi Caputi, Andrea Saladino, Francesco Acerbi, Elisa Ciceri
BACKGROUND: Sacral dural arteriovenous fistulas (DAVFs) are rare vascular abnormalities of the spine characterised by slowly progressive symptoms that can mimic different myelopathy disorders. OBJECT: To report our single Institution experience with sacral DAVFs. METHODS: We retrospectively reviewed the clinical records of patients admitted from 1 January 2006 to 31 December 2016 with a diagnosis of sacral DAVFs, treated by endovascular embolisation or surgical clipping...
October 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29024234/vicariously-touching-products-through-observing-others-hand-actions-increases-purchasing-intention-and-the-effect-of-visual-perspective-in-this-process-an-fmri-study
#18
Yi Liu, Xuelian Zang, Lihan Chen, Leonardo Assumpção, Hong Li
The growth of online shopping increases consumers' dependence on vicarious sensory experiences, such as observing others touching products in commercials. However, empirical evidence on whether observing others' sensory experiences increases purchasing intention is still scarce. In the present study, participants observed others interacting with products in the first- or third-person perspective in video clips, and their neural responses were measured with functional magnetic resonance imaging (fMRI). We investigated (1) whether and how vicariously touching certain products affected purchasing intention, and the neural correlates of this process; and (2) how visual perspective interacts with vicarious tactility...
October 11, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29023591/a-combination-of-selected-mapping-and-clipping-to-increase-energy-efficiency-of-ofdm-systems
#19
Byung Moo Lee, You Seung Rim, Wonjong Noh
We propose an energy efficient combination design for OFDM systems based on selected mapping (SLM) and clipping peak-to-average power ratio (PAPR) reduction techniques, and show the related energy efficiency (EE) performance analysis. The combination of two different PAPR reduction techniques can provide a significant benefit in increasing EE, because it can take advantages of both techniques. For the combination, we choose the clipping and SLM techniques, since the former technique is quite simple and effective, and the latter technique does not cause any signal distortion...
2017: PloS One
https://www.readbyqxmd.com/read/29022896/microrna-378-protects-against-intestinal-ischemia-reperfusion-injury-via-a-mechanism-involving-the-inhibition-of-intestinal-mucosal-cell-apoptosis
#20
Yunsheng Li, Shihong Wen, Xi Yao, Weifeng Liu, Jiantong Shen, Wentao Deng, Jing Tang, Cai Li, Kexuan Liu
Intestinal ischemia/reperfusion (I/R) injury remains a major clinical event and contributes to high morbidity and mortality rates, but the underlying mechanisms remain elusive. Recent studies have demonstrated that microRNAs (miRNAs) have important roles in organ I/R injury, but the changes and potential roles of miRNAs in intestinal I/R-induced intestinal injury are unclear. This study was designed to analyze the miRNA expression profiles in intestinal mucosa after I/R injury and to explore the role of target miRNA during this process...
October 12, 2017: Cell Death & Disease
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