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Sajad Hassanzadeh, Seyed Behnamedin Jameie, Mehdi Mehdizadeh, Mansooreh Soleimani, Zeinab Namjoo, Maryam Soleimani
Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Recently, the expression of FNDC5 was reported in cerebellar Purkinje cells as a possible neuroprotective agent. In the present study, we considered the expression of FNDC5 in Purkinje cells following SCI with and without MP administration in adult rats with SCI...
May 7, 2018: Neuropeptides
A Relea, J A Alonso, M González, C Zornoza, S Bahamonde, B E Viñuela, M B Encinas
OBJECTIVE: To determine whether the twinkling artifact on Doppler ultrasound imaging corresponds to microcalcifications previously seen on mammograms and to evaluate the usefulness of this finding in the ultrasound management of suspicious microcalcifications. MATERIAL AND METHODS: We used ultrasonography to prospectively examine 46 consecutive patients with groups of microcalcifications suspicious for malignancy identified at mammography, searching for the presence of the twinkling artifact to identify the microcalcifications...
June 12, 2018: Radiología
Isaac Josh Abecassis, Rajeev D Sen, Jason Barber, Rakshith Shetty, Cory M Kelly, Basavaraj V Ghodke, Danial K Hallam, Michael R Levitt, Louis J Kim, Laligam N Sekhar
BACKGROUND: Endovascular treatment of intracranial aneurysms is associated with higher rates of recurrence and retreatment, though contemporary rates and risk factors for basilar tip aneurysms (BTAs) are less well-described. OBJECTIVE: To characterize progression, retreatement, and retreated progression of BTAs treated with microsurgical or endovascular interventions. METHODS: We retrospectively reviewed records for 141 consecutive BTA patients...
June 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
Malay Sharma, Rajendra Lingampalli, Saurabh Jindal, Piyush Somani
No abstract text is available yet for this article.
August 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Susan Rowland, James Hardy, Kay Colthorpe, Rhianna Pedwell, Louise Kuchel
The ability to communicate is a crucial graduate outcome for science students; however, crowded curricula and large class sizes make it difficult to find time to explicitly teach foundational communication skills. In response to these challenges, we developed an online resource called Communication Learning in Practice for Scientists, or CLIPS. CLIPS provides a multi-point mentoring model that has allowed us to successfully integrate the teaching and learning of a complex set of tacitly-understood skills across multiple scientific disciplines...
2018: Journal of Microbiology & Biology Education: JMBE
Xue Guo, Xishu Zhou, Lauren Hale, Mengting Yuan, Jiajie Feng, Daliang Ning, Zhou Shi, Yujia Qin, Feifei Liu, Liyou Wu, Zhili He, Joy D Van Nostrand, Xueduan Liu, Yiqi Luo, James M Tiedje, Jizhong Zhou
Clipping, removal of aboveground plant biomass, is an important issue in grassland ecology. However, few studies have focused on the effect of clipping on belowground microbial communities. Using integrated metagenomic technologies, we examined the taxonomic and functional responses of soil microbial communities to annual clipping (2010-2014) in a grassland ecosystem of the Great Plains of North America. Our results indicated that clipping significantly ( P < 0.05) increased root and microbial respiration rates...
2018: Frontiers in Microbiology
Atsuki Ito, Matthias S Gobel, Yukiko Uchida
Previous research has shown that leadership is signaled through nonverbal assertiveness. However, those studies have been mostly conducted in individualistic cultural contexts, such as in the U.S. Here, we suggest that one important strategy for goal attainment in collectivistic cultures is for leaders to self-regulate their behaviors. Thus, contrary to the previous evidence from individualistic cultural contexts, in collectivistic cultural contexts, leaders might suppress nonverbal assertiveness. To test this possibility, we assessed nonverbal behaviors (NVB) of Japanese leaders and members, and how they were evaluated by observers...
2018: Frontiers in Psychology
Amy B Emerman, Michael Blower
RNA-binding proteins (RBPs) are critical regulators of gene expression. Recent studies have uncovered hundreds of mRNA-binding proteins that do not contain annotated RNA-binding domains and have well-established roles in other cellular processes. Investigation of these nonconventional RBPs is critical for revealing novel RNA-binding domains and may disclose connections between RNA regulation and other aspects of cell biology. Endosomal sorting complex required for transport II (ESCRT-II) is a nonconventional RNA-binding complex that has a canonical role in multivesicular body formation...
June 14, 2018: Journal of Biological Chemistry
Alberto Di Somma, Paloma Cancela, Magdalena Olivares, Teresa Somma, Antonio López-González, Alvaro Campero, Juan Emmerich, Javier Márquez-Rivas
BACKGROUND: and importance: Lesions located lateral to the lower brainstem, such as proximal posterior inferior cerebellar artery (PICA) aneurysms, are surgically challenging. In this study we report a case of a patient with a left proximal PICA aneurysm that was successfully clipped via a so-called "extended" suboccipital subtonsillar approach, which allowed to obtain proper vascular control without removal of the atlas. The anatomy relevant for this approach has been studied...
June 11, 2018: World Neurosurgery
Stefan Haufe, Paul DeGuzman, Simon Henin, Michael Arcaro, Christopher J Honey, Uri Hasson, Lucas C Parra
Human brain mapping relies heavily on fMRI, ECoG and EEG, which capture different physiological signals. Relationships between these signals have been established in the context of specific tasks or during resting state, often using spatially confined concurrent recordings in animals. But it is not certain whether these correlations generalize to other contexts relevant for human cognitive neuroscience. Here, we address the case of complex naturalistic stimuli and ask two basic questions. First, how reliable are the responses evoked by a naturalistic audio-visual stimulus in each of these imaging methods, and second, how similar are stimulus-related responses across methods? To this end, we investigated a wide range of brain regions and frequency bands...
June 11, 2018: NeuroImage
Baekgyu Kim, V Narry Kim
CLIP-seq (crosslinking immunoprecipitation and sequencing) is widely used to map the binding sites of a protein of interest on the transcriptome, and generally employs UV to induce the covalent bonds between protein and RNA, which allows stringent washing. However, dsRNA is inefficiently crosslinked by UV, making it difficult to study the interactions between dsRNA binding proteins and their substrates. A dsRNA endoribonuclease DROSHA initiates the maturation of microRNA (miRNA) by cleaving primary miRNA (pri-miRNA)...
June 11, 2018: Methods: a Companion to Methods in Enzymology
F O Turov, S P Yatsyk, I V Poddubnyi, T M Glybina, O I Bespalyuk
AIM: To improve treatment results of children undergoing laparoscopic genitourinary surgery by optimizing intraoperative hemostasis. MATERIALS AND METHODS: The study comprised 110 children with various genitourinary diseases. The study group included 70 children who underwent laparoscopic surgery with optimized hemostasis with the use of an automated electrosurgical vessels ligation device LigaSure. Forty children who received standard intraoperative hemostasis with mono- or bipolar coagulation made up a control group...
May 2018: Urologii︠a︡
Martin Graversen, Sönke Detlefsen, Jon Kroll Bjerregaard, Claus Wilki Fristrup, Per Pfeiffer, Michael Bau Mortensen
Background: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a laparoscopy-guided administration of aerosolized chemotherapy. PIPAC seems to improve objective tumor response, survival and quality of life in patients with peritoneal metastasis. We assessed feasibility and efficacy of PIPAC in patients with peritoneal metastasis (PM). Methods: Patients were included in a prospective PIPAC protocol. Patients with colorectal PM were treated with oxaliplatin, patients with other primary tumors were treated with cisplatin and doxorubicin...
2018: Therapeutic Advances in Medical Oncology
Kai Quan, Sichen Li, Dongdong Wang, Yuan Shi, Zixiao Yang, Jianping Song, Yanlong Tian, Yingjun Liu, Zhiyuan Fan, Wei Zhu
Background: Inflammatory cells, such as macrophages, play key roles in the pathogenesis of intracranial aneurysms (IAs). Berberine (BBR), an active component of a Chinese herb Coptis chinensis French , has been shown to have anti-inflammatory properties through suppressing macrophage migration in various inflammation animal model. The goal of this study was to examine BBR's effect on inflammation and IAs formation in a rodent aneurysm model. Methods and Results: Human aneurysm tissues were collected by microsurgical clipping and immunostained for phospho-Focal adhesion kinase (FAK) and CD68+ macrophages...
2018: Frontiers in Pharmacology
Elke Tieftrunk, Ihsan Ekin Demir, Stephan Schorn, Mine Sargut, Florian Scheufele, Lenika Calavrezos, Rebekka Schirren, Helmut Friess, Güralp O Ceyhan
BACKGROUND: Pancreatic fistula/PF is the most frequent and feared complication after distal pancreatectomy/DP. However, the safest technique of pancreatic stump closure remains an ongoing debate. Here, we aimed to compare the safety of different pancreatic stump closure techniques for preventing PF during DP. METHODS: We performed a PRISMA-based meta-analysis of all relevant studies that compared at least two techniques of stump closure during DP with regard to PF rates/PFR...
2018: PloS One
Robert C Rennert, Ben A Strickland, Kristine Ravina, Joshua Bakhsheshian, Vance Fredrickson, Joseph Carey, Jonathan J Russin
BACKGROUND: Revascularization strategies for complex cerebral aneurysms are largely based on subjective interpretation of flow demands, or indirect measures of perfusion in at-risk territories. Indocyanine Green -based flow analyses ((ICG-BFA); Flow 800, Carl Zeiss, Oberkochen, Germany) provide a real-time, semiquantitative measure of intraoperative cortical perfusion during cerebral bypass surgery for complex aneurysms. OBJECTIVE: To determine the utility of intraoperative ICG-BFA for assessing cortical perfusion in at-risk territories during cerebral bypass for complex aneurysms requiring vessel sacrifice...
June 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
Cassie L Caudill, Jillian L Perry, Shaomin Tian, J Christopher Luft, Joseph M DeSimone
Microneedle patches, arrays of micron-scale projections that penetrate skin in a minimally invasive manner, are a promising tool for transdermally delivering therapeutic proteins. However, current microneedle fabrication techniques are limited in their ability to fabricate microneedles rapidly and with a high degree of control over microneedle design parameters. We have previously demonstrated the ability to fabricate microneedle patches with a range of compositions and geometries using the novel additive manufacturing technique Continuous Liquid Interface Production (CLIP)...
June 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yang Gou, Danyan Liu, Jinfeng Liu, Hongran Sun
Bone mesenchymal stem cells (BMSCs) have been used worldwide to treat spinal cord injury, but their therapeutic mechanism is poorly understood. In this study, BMSCs were transplanted to aneurysm clip-injured rats to demonstrate their protective effect. We observed myelin sheaths through Luxol fast blue (LFB) staining, osmic acid staining, TUNEL and transmission electron microscopy (TEM). We performed Western blotting to analyze the expressions of brain-derived neurotrophic factor (BDNF) and caspase 3. BMSCs were transplanted at 1, 7 and 14 days after spinal cord injury...
May 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
C Linti, M Doser, H Planck, S Oberhoffner, E Mueller, M Renardy, J Biesinger, B Neumann, K Stang, T O Greiner, C Schlensak, S Krajewski, H P Wendel
Following percutaneous coronary intervention, vascular closure devices (VCDs) are increasingly used to reduce time to ambulation, enhance patient comfort, and reduce potential complications compared with traditional manual compression. Newer techniques include complicated, more or less automated suture devices, local application of pads or the use of metal clips and staples. These techniques often have the disadvantage of being time consuming, expensive or not efficient enough. The VCD failure rate in association with vascular complications of 2...
June 11, 2018: Journal of Materials Science. Materials in Medicine
Nadia Menon, Richard I Kemp, David White
Familiarity incrementally improves our ability to identify faces. It has been hypothesized that this improvement reflects the refinement of memory representations which incorporate variation in appearance across encounters. Although it is established that exposure to variation improves face identification accuracy, it is not clear how variation is assimilated into internal face representations. To address this, we used a novel approach to isolate the effect of integrating separate exposures into a single-identity representation...
May 2018: Royal Society Open Science
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