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https://www.readbyqxmd.com/read/29666793/self-assembly-of-a-1-1-ionic-hexagonal-macrocycle-and-its-antiproliferative-activity
#1
Khushwant Singh, Ankit Gangrade, Sourav Bhowmick, Achintya Jana, Biman B Mandal, Neeladri Das
A unique irregular hexagon was self-assembled using an organic donor clip (bearing terminal pyridyl units) and a complementary organometallic acceptor clip. The resulting metallamacrocycle was characterized by multinuclear NMR, mass spectrometry, and elemental analyses. Molecular modeling confirmed hexagonal shaped cavity for this metallamacrocycle which is a unique example of a discrete hexagonal framework self-assembled from only two building blocks. Cytotoxicity of the Pt-based acceptor tecton and the self-assembled PtII -based macrocycle was evaluated using three cancer cell lines and results were compared with cisplatin...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29666721/needle-knife-fistulotomy-for-the-rescue-an-unusual-cause-of-iatrogenic-extrahepatic-biliary-obstruction
#2
Laura L Ulmer, Lokesh K Jha, Neil Bhogal, Saurabh Kapur, Saurabh Chandan, Derrick Eichele, Ishfaq Bhat, Shailender Singh
A 71-year-old male presented to our institution with cholestatic hepatitis after having recently undergone upper endoscopy for treatment of gastrointestinal bleeding. Further investigation with endoscopic retrograde cholangiopancreatography revealed a hemostatic clip on the ampulla of Vater. After initial attempts at cannulation of the common bile duct were unsuccessful, biliary decompression was achieved by use of needle-knife fistulotomy. A common bile duct stent was placed and the liver function tests improved prior to discharge...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29665592/-videothoracoscopic-sympathetic-clipping-in-a-patient-with-azygos-lobe-intraoperative-management-to-avoid-potential-complications
#3
Waldemar Schreiner, Iurii Mykoliuk, Wojciech Dudek, Horia Sirbu
INTRODUCTION: Sympathetic clipping in the presence of an azygos lobe is a rare combination. Anatomical relations between the sympathetic trunk and the mesoazygos impede surgical handling and can be associated with potential complications. INDICATION: We report the case of a 25-year old woman with grade III palmoplantar and axillary hyperhidrosis with azygos lobe incidentally found on preoperative chest X-ray. METHOD: Our intraoperative video shows a step-by-step approach to the sympathetic trunk in the presence of the azygos lobe, involving thoracoscopic looping and precise clip application onto the sympathetic trunk...
April 17, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29664867/short-and-long-term-outcomes-of-titanium-clip-ossiculoplasty
#4
Charissa N Kahue, Brendan P O'Connnell, Matthew M Dedmon, David S Haynes, Alejandro Rivas
OBJECTIVE: To report short (∼4 mo) and long-term (>12 mo) audiometric outcomes following ossiculoplasty using a titanium clip partial ossicular reconstruction prosthesis. METHODS: Case series at a single tertiary referral center reviewing 130 pediatric and adult patients with conductive hearing loss (CHL) secondary to chronic otitis media (n = 121, 93%) or traumatic ossicular disruption (n = 9, 7%) who underwent partial ossiculoplasty from January 2005 to December 2015 with the CliP prosthesis...
April 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29660547/surgical-treatment-of-large-or-giant-fusiform-middle-cerebral-artery-aneurysms-a-case-series
#5
Feng Xu, Bin Xu, Lei Huang, Ji Xiong, Yuxiang Gu, Michael T Lawton
BACKGROUND: Management of large or giant fusiform middle cerebral artery (MCA) aneurysms represents a significant challenge. OBJECTIVE: To describe the author's experience in the treatment of large or giant fusiform MCA aneurysm by using various surgical techniques. METHODS: We retrospectively reviewed a database of aneurysm treated at our division between 2015 and 2017. RESULTS: Overall, 20 patients (11 males, 9 females) were identified with a mean age of 40...
April 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29660354/novel-treatment-for-anastomotic-leak-following-ivor-lewis-esophagectomy
#6
Joseph Costa, Lyall A Gorenstein, Frank D'Ovidio
Intra-thoracic anastomotic leaks following esophagogastrostomy occur frequently, often resulting in prolonged hospitalization and delays in advancing oral nutrition and hydration. Management of anastomotic esophageal leaks vary based on time of occurrence to the intervention, condition of the patient and location. Conservative approaches such as endo-clips and endo-stents have gained momentum in addressing esophageal leaks and fistulas, replacing the original paradigm of surgical approach as initial management...
April 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29660038/external-ventricular-drain-and-hemorrhage-in-aneurysmal-subarachnoid-hemorrhage-patients-on-dual-antiplatelet-therapy-a-retrospective-cohort-study
#7
Joseph S Hudson, Benjamin S Prout, Yasunori Nagahama, Daichi Nakagawa, Waldo R Guerrero, Mario Zanaty, Nohra Chalouhi, Pascal Jabbour, Sudeepta Dandapat, Lauren Allan, Santiago Ortega-Gutierrez, Edgar A Samaniego, David Hasan
BACKGROUND: Stenting and flow diversion for aneurysmal sub arachnoid hemorrhage (aSAH) require the use of dual antiplatelet therapy (DAPT). OBJECTIVE: To investigate whether DAPT is associated with hemorrhagic complication following placement of external ventricular drains (EVD) in patients with aSAH. METHODS: Rates of radiographically identified hemorrhage associated with EVD placement were compared between patients who received DAPT for stenting or flow diversion, and patients who underwent microsurgical clipping or coiling and did not receive DAPT by way of a backward stepwise multivariate analysis...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29659719/pysster-classification-of-biological-sequences-by-learning-sequence-and-structure-motifs-with-convolutional-neural-networks
#8
Stefan Budach, Annalisa Marsico
Summary: Convolutional neural networks (CNNs) have been shown to perform exceptionally well in a variety of tasks, including biological sequence classification. Available implementations, however, are usually optimized for a particular task and difficult to reuse. To enable researchers to utilize these networks more easily we implemented pysster, a Python package for training CNNs on biological sequence data. Sequences are classified by learning sequence and structure motifs and the package offers an automated hyper-parameter optimization procedure and options to visualize learned motifs along with information about their positional and class enrichment...
April 6, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29658644/current-status-and-future-perspectives-of-endoscopic-full-thickness-resection
#9
REVIEW
Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Tsutomu Masaki
Flexible endoscopy has developed from a diagnostic tool for tissue biopsy sampling to a treatment tool for endoscopic resection of neoplasms in the digestive tract. In the near future, one of the advanced endoscopic techniques, endoscopic full-thickness resection (EFTR), is expected to be a feasible endoscopic procedure. In the present review, systematic review of conventional exposed EFTR was carried out. Search queries were (endoscopic full-thickness resection or EFTR) (over-the-scope clip or OTSC) (Overstitch System) from 2015 to 2017...
April 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29658102/earfold-a-new-technique-for-correction-of-the-shape-of-the-antihelix
#10
Norbert V Kang, Walid Sabbagh, Greg O'Toole, Michael Silberberg
An absent or poorly defined antihelix often plays a central role in the perception of the prominent ear. A wide variety of otoplasty techniques have been described over the last 50 years that aim to reshape, create, or enhance the definition of the antihelix, which can, in turn, help to reduce the prominence of an ear. In addition to conventional suture and cartilage-scoring techniques, a permanent implantable clip system (Earfold® ) has recently become available that is placed using a minimally invasive approach performed under local anesthesia...
April 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29656151/total-hospital-costs-thc-and-length-of-stay-los-of-endovascular-coiling-versus-neurosurgical-clipping-for-unruptured-intracranial-aneurysms-a-systematic-review-and-meta-analysis
#11
REVIEW
Xiaoxi Zhang, Haishuang Tang, Qinghai Huang, Bo Hong, Yi Xu, Jianmin Liu
OBJECTIVE: Comparison of feasibility and safety between endovascular coiling versus neurosurgical clipping for the management of unruptured intracranial aneurysms (UIA) has been incrementally reported. However, economic comparison has been rarely reported. This meta analysis aims at qualitatively and quantitatively analyzing the difference of hospital costs and length of stay between endovascular versus neurosurgical treatment in UIA. METHODS: MEDLINE, the Cochrane database, EMBASE and Web of Science database were searched for cohort studies describing economic hospital cost or length of stay in patients with UIA...
April 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29655645/proton-beam-irradiation-a-safe-procedure-in-post-equatorial-extraocular-extension-from-uveal-melanoma
#12
Ira Seibel, Aline I Riechardt, Katharina Erb-Eigner, Alexander Böker, Dino Cordini, Jens Heufelder, Antonia M Joussen
PURPOSE: This study was performed to show long-term outcomes concerning metastasis rates and local recurrence rates after primary proton beam therapy in uveal melanoma with posterior extraocular extension (EOE) with the main focus on optic nerve invasion. DESIGN: Retrospective case series METHODS: All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma with posterior EOE between July 1998 and August 2010 were included. EOE was either detected upon sonography at primary examination or during the surgical application of tantalum clips onto the sclera...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29653448/closure-of-a-mucosal-defect-with-clips-and-rubber-band-a-technical-trick-to-improve-edge-apposition-in-large-mucosal-defects
#13
Alexandru Lupu, Jérémie Jacques, Jérôme Rivory, Florian Rostain, Romain Legros, Thierry Ponchon, Mathieu Pioche
No abstract text is available yet for this article.
April 13, 2018: Endoscopy
https://www.readbyqxmd.com/read/29649463/common-hepatic-duct-stricture-due-to-surgical-clip
#14
Arslan Talat, Demetrios Tzimas, Juan Carlos Bucobo
No abstract text is available yet for this article.
April 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29642850/using-observational-facial-descriptors-to-infer-pain-in-persons-with-and-without-dementia
#15
Stefan Lautenbacher, Anna Lena Walz, Miriam Kunz
BACKGROUND: For patients with advanced dementia, pain diagnosis and assessment requires observations of pain-indicative behavior by others. One type of behavior that has been shown to be a promising candidate is the facial response to pain. To further test how pain-indicative facial responses are, we investigated the predictive power of observational facial descriptors to (i) predict the self-report of pain and (ii) to differentiate between non-painful and painful conditions. In addition, the expertise of the observers (nurses vs...
April 11, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29629234/a-difficult-to-treat-acom-aneurysm-with-the-combined-vascular-anomaly-of-acom-fenestration-and-accessory-anterior-cerebral-artery
#16
Hideyuki Tomita, Katsuya Saito
Background: Vascular anomaly and aneurysmal formation of an anterior communicating artery (Acom) complex has often been reported. Because of such a complicated relationship between the vascular structure and aneurysms, Acom aneurysm is one of the most difficult aneurysms to treat among other common anterior circulation aneurysms. We experienced an extremely rare and difficult-to-treat case of ruptured Acom aneurysm with the combined vascular anomaly of the Acom fenestration and an accessory anterior cerebral artery (ACA)...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29629041/comparison-of-patient-physician-interaction-scores-of-clinical-practice-examination-between-checklists-and-rating-scale
#17
Nam Eun Kim, Hoon Ki Park, Kyong Min Park, Bong Kyung Seo, Kye Yeung Park, Hwan Sik Hwang
Background: The clinical practice examination (CPX) was introduced in 2010, and the Seoul-Gyeonggi CPX Consortium developed the patient-physician interaction (PPI) assessment tool in 2004. Both institutions use rating scales on classified sections of PPI but differ in their scoring of key components. This study investigated the accuracy of standardized patient scores across rating scales by comparing checklist methods and verified the concurrent validity of two comparable PPI rating tools...
March 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29628945/balloon-assisted-cannulation-for-difficult-anterior-cerebral-artery-access
#18
Varun Naragum, Mohamad AbdalKader, Thanh N Nguyen, Alexander Norbash
The anterior communicating artery is a common location for intracranial aneurysms. Compared to surgical clipping, endovascular coiling has been shown to improve outcomes for patients with ruptured aneurysms and we have seen a paradigm shift favoring this technique for treating aneurysms. Access to the anterior cerebral artery can be challenging, especially in patients with tortuous anatomy or subarachnoid hemorrhage or in patients presenting with vasospasm. We present a technique for cannulating the anterior cerebral artery using a balloon inflated in the proximal middle cerebral artery as a rebound surface...
February 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29627948/efficacy-of-utilizing-argon-plasma-coagulation-for-weight-regain-in-roux-en-y-gastric-bypass-patients-a-multi-center-study
#19
Rena C Moon, Andre F Teixeira, Manoel Galvao Neto, Natan Zundel, Bruno Queiroz Sander, Flavio Mitidieri Ramos, Felipe Matz, Giorgio A Baretta, Luiz Gustavo de Quadros, Eduardo Grecco, Thiago Souza, Sergio A Barrichello, Admar Concon Filho, Eduardo Nobuyuki Usuy, Artagnan Menezes Barbosa de Amorim, Muhammad A Jawad
BACKGROUND: Endoscopic approaches exist for targeting weight regain after Roux-en-Y gastric bypass (RYGB), including endoscopic suturing, clipping, and sclerotherapy. Argon plasma coagulation (APC) is a noncontact electrocoagulation method, and when used in RYGB patients, it has shown reduction in the diameter of the gastrojejunal anastomosis. OBJECTIVES: To study the effectiveness of APC for weight regain in terms of weight loss for RYGB patients, from eight bariatric centers...
April 8, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29625957/development-and-feasibility-testing-of-internet-delivered-acceptance-and-commitment-therapy-for-severe-health-anxiety-pilot-study
#20
Ditte Hoffmann, Charlotte Ulrikka Rask, Erik Hedman-Lagerlöf, Brjánn Ljótsson, Lisbeth Frostholm
BACKGROUND: Severe health anxiety (hypochondriasis), or illness anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, is characterized by preoccupation with fear of suffering from a serious illness in spite of medical reassurance. It is a debilitating, prevalent disorder associated with increased health care utilization. Still, there is a lack of easily accessible specialized treatment for severe health anxiety. OBJECTIVE: The aims of this paper were to (1) describe the development and setup of a new internet-delivered acceptance and commitment therapy (iACT) program for patients with severe health anxiety using self-referral and a video-based assessment; and (2) examine the feasibility and potential clinical efficacy of iACT for severe health anxiety...
April 6, 2018: JMIR Mental Health
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