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https://www.readbyqxmd.com/read/28533671/consequences-of-metabolic-syndrome-on-postoperative-outcomes-after-pancreaticoduodenectomy
#1
Alban Zarzavadjian Le Bian, David Fuks, Sophie Chopinet, Sébastien Gaujoux, Manuela Cesaretti, Renato Costi, Ajay P Belgaumkar, Claude Smadja, Brice Gayet
AIM: To analyze immediate postoperative outcomes after pancreaticoduodenectomy regarding metabolic syndrome. METHODS: In two academic centers, postoperative outcomes of patients undergoing pancreaticoduodenectomy from 2002 to 2014 were prospectively recorded. Patients presenting with metabolic syndrome [defined as at least three criteria among overweight (BMI ≥ 28 kg/m²), diabetes mellitus, arterial hypertension and dyslipidemia] were compared to patients without metabolic syndrome...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28533536/a-systemic-review-and-an-updated-meta-analysis-minimally-invasive-vs-open-pancreaticoduodenectomy
#2
Zhanwei Zhao, Zifang Yin, Zhenning Hang, Gang Ji, Quanxin Feng, Qingchuan Zhao
The feasible of minimally invasive pancreaticoduodenectomy (MIPD) remains controversial when compared with open pancreaticoduodenectomy (OPD). We conducted a systemic review and meta-analysis to summarise the available evidence to compare MIPD vs OPD. We systemically searched PubMed, EMBASE and Web of Science for studies published through February 2016. The primary endpoint was postoperative pancreatic fistula (POPF, grade B/C). A total of 27 studies involving 14,231 patients (2,377 MIPD and 11,854 OPD) were included...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28523348/closed-loop-of-main-duct-of-pancreas-a-rare-variant-configuration
#3
Harsimran Jit Singh, Anjali Aggarwal, Rakesh K Kochhar, T D Yadav, Tulika Gupta, Daisy Sahni
During routine dissection, duplication of main pancreatic duct extending from body to head region of pancreas was observed in a 78-year-old formalin fixed male cadaver. Main pancreatic duct gave a prominent branch which joined back the parent duct in head resulting in the formation of a closed loop. This gave the appearance of focal duplication in the form of a closed loop, an unusual variant. This was an incidental finding. Such cases usually remain asymptomatic; however, if undetected may be the cause of postoperative pancreatic fistula following pancreaticobiliary surgery...
May 18, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28522378/a-comparative-study-of-risk-factors-for-pancreatic-fistula-after-pancreatoduodenectomy-or-distal-pancreatectomy
#4
James M Halle-Smith, Eduardo Vinuela, Rachel M Brown, James Hodson, Zergham Zia, Simon R Bramhall, Ravi Marudanayagam, Robert P Sutcliffe, Darius F Mirza, Paolo Muiesan, John Isaac, Keith J Roberts
BACKGROUND: Evidence associates various biometric and histological variables such as steatosis and absence of fibrosis as risk factors for post-operative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). Following distal pancreatectomy (DP), the association between these factors and POPF is less clear. This study of patients, drawn from the same background population, undergoing PD or DP at a single centre is a comparative study of the risk factors for POPF after these two operations...
May 15, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28521286/duct-to-mucosa-versus-invagination-pancreaticojejunostomy-after-pancreaticoduodenectomy-a-meta-analysis
#5
Shuisheng Zhang, Zhongmin Lan, Jianwei Zhang, Yingtai Chen, Quan Xu, Qinglong Jiang, Yajie Zhao, Chengfeng Wang, Xiaoning Bi, Xiaozhun Huang
OBJECTIVE: We aimed to compare the two most commonly used pancreatico-jejunostomy reconstruction techniques-duct-to-mucosa and invagination. METHODS: Databases, including MEDLINE, EMBASE, Cochrane Library, and several clinical trial registration centers were searched. Randomized controlled trials that compared duct-to-mucosa and invagination pancreaticojejunostomy techniques after pancreaticoduodenectomy were included and analyzed. RESULTS: In total, seven RCTs were included, involving 850 patients...
April 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28520649/the-effectiveness-and-feasibility-of-endoscopic-ultrasound-guided-transgastric-drainage-of-postoperative-fluid-collections-early-after-pancreatic-surgery
#6
Yasuro Futagawa, Hiroo Imazu, Naoki Mori, Keisuke Kanazawa, Masafumi Chiba, Kenei Furukawa, Taro Sakamoto, Hiroaki Shiba, Katsuhiko Yanaga
PURPOSES: To assess the feasibility and usefulness of endoscopic ultrasound-guided transgastric drainage (EUS-GD) in patients who required early postoperative drainage of peripancreatic fluid collection or postoperative pancreatic fistulas after pancreatic surgery. PATIENTS AND METHODS: Between May 2012 and January 2016, 33 patients who developed peripancreatic fluid collection or postoperative pancreatic fistulas after pancreatic resection underwent EUS-GD or percutaneous drainage (PTD)...
May 17, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28516291/downstaging-in-stage-iv-pancreatic-cancer-a-new-population-eligible-for-surgery
#7
Isabella Frigerio, Paolo Regi, Alessandro Giardino, Filippo Scopelliti, Roberto Girelli, Claudio Bassi, Stefano Gobbo, Paolo Tinazzi Martini, Paola Capelli, Mirko D'Onofrio, Giuseppe Malleo, Laura Maggino, Elena Viviani, Giovanni Butturini
BACKGROUND: Recent papers consider surgery as an option for synchronous liver oligometastatic patients [metastatic pancreatic ductal adenocarcinoma (mPDAC)]. In this study, we present our series of resected mPDACs after neoadjuvant chemotherapy (nCT). PATIENTS AND METHODS: All patients resected after downstaging of mPDAC were included in this study. Downstaging criteria were disappearance of liver metastasis and a decrease in cancer antigen (CA) 19-9. The type and duration of nCT, last nCT surgery interval, histology, morbidity, and mortality were recorded, and overall survival (OS) and disease-free survival (DFS) were analyzed...
May 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28515932/single-stage-laparoscopic-adrenalectomy-for-pheochromocytoma-and-enucleation-of-a-pancreatic-neuroendocrine-tumor-in-von-hippel-lindau-disease-a-case-report
#8
Marco Casaccia, Simona Macina, Rosario Fornaro
Von Hippel-Lindau (VHL) disease is an inherited syndrome with autosomal-dominant transmission, characterized by central nervous system and retinal hemangioblastomas, visceral cysts and tumors. Optimal surgical treatment, including its timing, remains a controversial topic. The present study reports the case of a 67-year-old female patient with adrenal and pancreatic manifestations of VHL. A laparoscopic cortex-sparing left adrenalectomy for a 4-cm pheochromocytoma and pancreatic enucleation for pancreatic polypeptidoma of the pancreas tail were performed during the same operative procedure...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28513069/predict-pancreatic-fistula-after-pancreaticoduodenectomy-ratio-body-thickness-main-duct
#9
Louise Barbier, Diane Mège, Anthony Reyre, Vincent M Moutardier, Jacques A Ewald, Jean-Robert Delpero
BACKGROUND: The occurrence of post-operative pancreatic fistula (POPF) after pancreaticoduodenectomy is a challenging issue. The aim was to identify variables on preoperative computed tomography (CT) scan, useful to predict clinically significant POPF (grades B-C) after pancreaticoduodenectomy. METHODS: Patients presented POPF after pancreaticoduodenectomy were included from two tertiary referral centres. B/W ratio was defined by ratio of pancreas body thickness (B) to main pancreatic duct (W)...
May 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28511699/does-intraoperative-closed-suction-drainage-influence-the-rate-of-pancreatic-fistula-after-pancreaticoduodenectomy
#10
Ophélie Aumont, Aurélien Dupré, Adeline Abjean, Bruno Pereira, Julie Veziant, Bertrand Le Roy, Denis Pezet, Emmanuel Buc, Johan Gagnière
BACKGROUND: Although drainage of pancreatic anastomoses after pancreaticoduodenectomy (PD) is still debated, it remains recommended, especially in patients with a high risk of post-operative pancreatic fistula (POPF). Modalities of drainage of pancreatic anastomoses, especially the use of passive (PAD) or closed-suction (CSD) drains, and their impact on surgical outcomes, have been poorly studied. The aim was to compare CSD versus PAD on surgical outcomes after PD. METHODS: Retrospective analysis of 197 consecutive patients who underwent a standardized PD at two tertiary centers between March 2012 and April 2015...
May 16, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28493949/prediction-of-pancreatic-fistula-after-pancreatoduodenectomy-by-preoperative-dynamic-ct-and-fecal-elastase-1-levels
#11
Jung-Hyun Kang, Joon Seong Park, Jeong-Sik Yu, Jae-Joon Chung, Joo Hee Kim, Eun-Suk Cho, Dong Sup Yoon
OBJECTIVE: To validate preoperative dynamic CT and fecal elastase-1 level in predicting the development of pancreatic fistulae after pancreatoduodenectomy. MATERIALS AND METHODS: For 146 consecutive patients, CT attenuation values of the nontumorous pancreatic parenchyma were retrospectively measured on precontrast, arterial and equilibrium phase images for calculation of enhancement ratios. CT enhancement ratios and preoperative fecal elastase-1 levels were correlated with the development of pancreatic fistulae using independent t-test, logistic regression models, ROC analysis, Youden method and tree analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28489778/pancreatoduodenectomy-pd-and-postoperative-pancreatic-fistula-popf-a-systematic-review-and-analysis-of-the-popf-related-mortality-rate-in-60-739-patients-retrieved-from-the-english-literature-published-between-1990-and-2015
#12
Sergio Pedrazzoli
BACKGROUND: Pancreatoduodenectomy (PD) is one of the most technically demanding operations challenging surgeons, and a postoperative pancreatic fistula (POPF) can complicate an otherwise uneventful postoperative (PO) course. This review examined the methods and procedures used to prevent postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). METHODS: A comprehensive systematic search of the literature was performed using PubMed (Medline), Embase, Web of science, and the Cochrane databases for studies published between January 1, 1990 and December 31, 2015...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28488004/minimally-invasive-versus-open-pancreatoduodenectomy-systematic-review-and-meta-analysis
#13
REVIEW
Michał Pędziwiatr, Piotr Małczak, Magdalena Pisarska, Piotr Major, Michał Wysocki, Tomasz Stefura, Andrzej Budzyński
PURPOSE: The purpose of this systematic review was to compare minimally invasive pancreatoduodenectomy (MIPD) versus open pancreatoduodenectomy (OPD) by using meta-analytical techniques. METHODOLOGY: Medline, Embase, and Cochrane Library were searched for eligible studies. Data from included studies were extracted for the following outcomes: operative time, overall morbidity, pancreatic fistula, delayed gastric emptying, blood loss, postoperative hemorrhage, yield of harvested lymph nodes, R1 rate, length of hospital stay, and readmissions...
May 9, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28486387/minimally-invasive-versus-open-pancreaticoduodenectomy-a-propensity-matched-study-from-a-national-cohort-of-patients
#14
Ibrahim Nassour, Sam C Wang, Alana Christie, Mathew M Augustine, Matthew R Porembka, Adam C Yopp, Michael A Choti, John C Mansour, Xian-Jin Xie, Patricio M Polanco, Rebecca M Minter
OBJECTIVE: To compare the perioperative outcomes of minimally invasive pancreaticoduodenectomy (MIPD) in comparison with open pancreaticoduodenectomy (OPD) in a national cohort of patients. BACKGROUND: Limited well-controlled studies exist comparing perioperative outcomes between MIPD and OPD. METHODS: Patients who underwent MIPD and OPD were abstracted from the 2014 to 2015 pancreas-targeted American College of Surgeons National Surgical Quality Improvement Program...
May 8, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28477012/minimally-invasive-distal-pancreatectomy-for-pnets-laparoscopic-or-robotic-approach
#15
Jiaqiang Zhang, Jiabin Jin, Shi Chen, Jiangning Gu, Yi Zhu, Kai Qin, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Baiyong Shen, Chenghong Peng
BACKGROUND: The most effective and radical treatment for pancreatic neuroendocrine tumors (PNETs) is surgical resection. Minimally invasive surgery has been increasingly used in pancreatectomy. Initial results in robotic distal pancreatectomy (RDP) have been encouraging. Nonetheless, data comparing outcomes of RDP with those of laparoscopic distal pancreatectomy (LDP) in treating PNETs are rare. The aim of this study was to compare the safety and efficacy of RDP and LDP for PNETs. METHODS: From September 2010 to January 2017, operative parameters and perioperative outcomes in an initial experience with 43 consecutive patients undergoing RDP were collected and compared with those in 31 patients undergoing LDP...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28475221/influence-of-cholangitis-after-preoperative-endoscopic-biliary-drainage-on-postoperative-pancreatic-fistula-in-patients-with-middle-and-lower-malignant-biliary-strictures
#16
Toru Kaneko, Hiroshi Imaizumi, Mitsuhiro Kida, Eiji Miyata, Hiroshi Yamauchi, Kosuke Okuwaki, Tomohisa Iwai, Wasaburo Koizumi
BACKGROUND: Preoperative cholangitis after preoperative drainage has been reported to increase postoperative complications, particularly pancreatic fistula. We therefore examined the effects of cholangitis after preoperative endoscopic biliary drainage (EBD) on postoperative pancreatic fistula in patients with middle and lower malignant biliary strictures. METHODS: The study group comprised 102 patients who underwent EBD among patients who underwent surgery. RESULTS: Of the 102 patients, 33 (32%) had postoperative pancreatic fistulas, and 56 (55%) had preoperative cholangitis after preoperative drainage...
May 5, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28470943/serum-level-of-c-reactive-protein-on-postoperative-day-3-is-a-predictive-indicator-of-postoperative-pancreatic-fistula-after-laparoscopic-gastrectomy-for-gastric-cancer
#17
Tomoyuki Matsunaga, Hiroaki Saito, Yuki Murakami, Hirohiko Kuroda, Yoji Fukumoto, Tomohiro Osaki
INTRODUCTION: Postoperative pancreatic fistula (POPF) is a serious complication after gastrectomy for gastric cancer. It is vitally important to detect signs of POPF in the early postoperative period and perform adequate management to avoid patient death. The aim of this study was to investigate the predictive indicators of POPF after laparoscopic gastrectomy for gastric cancer. METHODS: The current study included 197 patients who were pathologically diagnosed with adenocarcinoma and underwent laparoscopic gastrectomy between January 2010 and December 2014 in our hospital...
May 4, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28468714/the-indications-for-laparoscopic-pancreatectomy
#18
Marco Siech, Peter Strauss, Stephanie Huschitt, Detlef K Bartsch, Uwe Wittel, Tobias Keck
BACKGROUND: Laparoscopic pancreatectomy is not yet established as a routine procedure everywhere in Germany or in other countries. Few data are available on its short- and long-term outcomes. METHODS: From 2008 onward, a working group initiated by 10 centers and currently comprising 34 centers has gathered data on all cases of laparoscopic pancreatectomy. Procedures in which laparoscopy was converted to open surgery are also included. RESULTS: The registry now contains 550 data sets representing 267 cases of benign disease, 244 malignancies, and 39 borderline tumors...
April 14, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28466004/are-internal-or-external-pancreatic-duct-stents-the-preferred-choice-for-patients-undergoing-pancreaticoduodenectomy-a-meta-analysis
#19
REVIEW
Yajie Zhao, Jianwei Zhang, Zhongmin Lan, Qinglong Jiang, Shuisheng Zhang, Yunmian Chu, Yingtai Chen, Chengfeng Wang
The technique of pancreatic duct stenting during pancreatic anastomosis can markedly reduce the incidence of postoperative pancreatic fistula (PF) after pancreaticoduodenectomy (PD). The method of drainage includes using either an external or an internal stent; the meta-analysis result shows us that there were no differences in the rates of postoperative complications between PD using internal stents and PD using external stents; internal stents may be more favorable during postoperative management of drainage tube...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28465259/clinical-effect-of-pancreaticojejunostomy-with-a-long-internal-stent-during-pancreaticoduodenectomy-in-patients-with-a-main-pancreatic-duct-of-small-diameter
#20
Tomohisa Yamamoto, Sohei Satoi, Hiroaki Yanagimoto, Satoshi Hirooka, So Yamaki, Hironori Ryota, Masaya Kotsuka, Yoichi Matsui, Masanori Kon
BACKGROUND: Post-operative pancreatic fistula (POPF) is one of the most common causes of death following pancreaticoduodenectomy (PD). The aim of this study was to evaluate the clinical effect of a long-internal stent on the development of POPF in patients with a main pancreatic duct diameter of 3 mm or less. STUDY DESIGN: Patients (N = 108) with a main pancreatic duct (≤3 mm) who underwent PD were included in this single-institution historical control study...
April 29, 2017: International Journal of Surgery
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