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https://www.readbyqxmd.com/read/29113670/primary-arthroplasty-in-healed-osteoarticular-allograft-in-patients-with-history-of-primary-femoral-bone-tumors
#1
Bianca M Verbeek, Courtney L Kaiser, Nuno Rui Paulino Pereira, Francis J Hornicek, Kevin A Raskin, Joseph H Schwab, Santiago A LozanoCalderón
BACKGROUND: Roughly 25-35% of patients who are treated with osteoarticular allograft for primary bone sarcomas or aggressive benign bone tumors require surgery in the long-term due to degenerative changes of the articular surface of the allograft. There are three established methods of reconstruction for this complication; a total hip arthroplasty (THA) or total knee arthroplasty (TKA) in the retained osteoarticular allograft, a proximal or distal endoprosthesis after removal of the allograft, and an allograft-prosthesis composite (APC)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113159/treatment-of-osteosarcoma-around-the-knee-in-skeletally-immature-patients
#2
Weitao Yao, Qiqing Cai, Jiaqiang Wang, Songtao Gao
Limb sparing surgery in growing young patients with malignant tumors is difficult as invasion of the physis by the tumor or surgical resection through the metaphysis may cause significant limb discrepancy following surgery. At present, hinged tumor prosthesis or biological reconstructions are the main methods following tumor resection in these patients. The aim of the present study was to assess different procedures for the treatment of osteosarcoma around knee joints in immature patients. A retrospective study of 56 patients (<15 years old, open physis) who had been treated for osteosarcoma around the knee joint between January 2007 and December 2015 was performed...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29098354/-total-elbow-arthroplasty-in-traumatic-and-post-traumatic-bone-defects
#3
REVIEW
M Hackl, L P Müller, T Leschinger, K Wegmann
Total elbow arthroplasty is currently most commonly carried out due to acute trauma or post-traumatic conditions. Bone defects are often present and must be considered in the (pre-)operative workup. The use of semi-constrained prostheses with a systematic cementing technique through a triceps-on approach leads to satisfying clinical results, however, the outcome is worse when compared with rheumatic patients.Primary total elbow arthroplasty for complex distal humerus fractures in the elderly patient or secondary implantation following failed conservative treatment or osteosynthesis represent possible indications for (post‑)traumatic joint replacement...
November 2, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29092120/immunologic-responses-in-biological-and-mechanical-valve-prostheses-inflammation-and-functionality-are-not-always-related
#4
Alejandra Rodriguez-Hernandez, Maria Elena Soto, Jesus Vargas-Barron, Ricardo Marquez, Rafael Bojalil-Parra, Israel Perez-Torres, Jose Luis Salas-Pacheco, Valentin Jimenez-Rojas, Jose Antonio Arias-Godinez, Veronica Guarner-Lans
BACKGROUND: The aim of this retrospective study was to evaluate the inflammatory response in patients with aortic and/or mitral prostheses, and to correlate the level of inflammatory markers with prosthesis functionality. METHODS: A total of 48 patients with biological or mechanical prostheses was included in the study, in which levels of tumor necrosis factor-alpha (TNFα), interleukin (IL)-1, -4, and -6, interferon-gamma (IFNγ), osteopontin (OPN), intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), endothelin-1 and C-reactive protein were analyzed...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29081066/long-term-outcomes-of-cement-in-cement-technique-for-revision-endoprosthesis-surgery
#5
Nicholas M Bernthal, Vishal Hegde, Stephen D Zoller, Howard Y Park, Jason H Ghodasra, Daniel Johansen, Frederick Eilber, Fritz C Eilber, Chandhanarat Chandhanayingyong, Jeffrey J Eckardt
BACKGROUND AND OBJECTIVE: Cemented endoprosthetic reconstruction after resection of primary bone sarcomas has been a standard-of-care option for decades. With increased patient survival, the incidence of failed endoprostheses requiring revision surgery has increased. Revision of cemented endoprotheses by cementing into the existing cement mantle (CiC) is technically demanding. METHODS: This is a retrospective review of our endoprosthesis database of 512 consecutive cemented endoprosthetic reconstructions performed for oncologic diagnoses between 1980 and 2014...
October 29, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29068573/en-bloc-resection-and-prosthesis-implantation-to-treat-malignant-fibrous-histiocytoma-of-the-humerus
#6
Jun Sun, Ru-Ming Zhang, Yu-Xin Zheng
BACKGROUND: Malignant fibrous histiocytoma (MFH) of the bone is a rare tumor. Most studies comparing limb salvage and amputation have reported that limb salvage had no adverse effect on the long-term survival of patients. This study evaluates the oncological outcomes of limb salvage procedures that were used for 15 patients with MFH of the humerus. OBJECTIVES: The aim of this study was to assess the functional and oncological outcomes of patients with malignant fibrous histiocytoma of the humerus after en bloc resection and prosthesis implantation...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29054719/two-cases-of-distal-ulna-giant-cell-tumors-treated-by-extensive-resection-prosthetic-reconstruction-and-stabilization-using-the-brachioradialis-tendon
#7
A Thiounn, E Guerre, C Szymanski, C Maynou, C Fontaine
Aggressive giant cell tumors are rare at the distal ulna. We report the results of two patients who were treated surgically using a distal ulna prosthesis stabilized by ligament reconstruction with the brachioradialis tendon. At the maximum follow-up of 18months, the two patients were satisfied. Joint range of motion and functional scores were improved. X-rays showed no recurrence or subluxation; however gradual impingement of the ulnar notch of radius by the prosthesis was visible. Our technique seems to be a viable alternative when compared with the treatments described in other published case reports...
October 17, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29052604/effect-of-topical-loteprednol-etabonate-with-lid-hygiene-on-tear-cytokines-and-meibomian-gland-dysfunction-in-prosthetic-eye-wearers
#8
J S Ko, Y Seo, M K Chae, S Y Jang, J S Yoon
PurposeTo assess tear cytokine levels and clinical outcomes in meibomian gland dysfunction (MGD) in the blind eye of patients wearing an ocular prosthesis after 2 months of treatment with topical loteprednol etabonate and eyelid scrubs with warm compresses.Patients and methodsThis study included patients with MGD wearing a unilateral ocular prosthesis for more than 1 year. All patients topically received 0.5% loteprednol etabonate and were instructed to scrub their eyelids with warm compresses on the prosthetic eye for 2 months...
October 20, 2017: Eye
https://www.readbyqxmd.com/read/29044894/immediate-implant-placement-and-provisionalization-following-tumor-resective-surgery-in-the-midfacial-region-a-case-series
#9
Nelson Fernandes, Jacobus van den Heever, Leanne Sykes
Surgical and prosthodontic restoration of the midfacial region following tumor resection has always posed a considerable challenge, as this area serves crucial functional and esthetic roles. Being diagnosed and subsequently treated for facial tumors can have an immense psychosocial impact on a patient, as the resulting defects are often disfiguring, and lead to an inability to masticate, swallow, and speak clearly. Provision of an immediate facial and dental prosthesis at the time of surgery can limit these side effects and help reduce mental duress on these patients and their families, as well as aid in the process of rehabilitation...
October 18, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29044605/amputations-for-extremity-soft-tissue-sarcoma-in-an-era-of-limb-salvage-treatment-local-control-and-survival
#10
Marc G Stevenson, Annelie H Musters, Jan H B Geertzen, Barbara L van Leeuwen, Harald J Hoekstra, Lukas B Been
BACKGROUND: Despite multimodality limb salvage treatment (LST) for locally advanced extremity soft tissue sarcoma (ESTS), some patients still need an amputation. Indications for amputation and oncological outcome for these patients are described. METHODS: Between 1996 and 2016, all patients who underwent an amputation for ESTS were included. Patients who underwent an amputation as primary or as non-primary treatment formed Group I and II, respectively. RESULTS: Thirty-nine patients were included, 16 in Group I (41%) and 23 in Group II (59%)...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29042738/prosthetic-rehabilitation-of-mandibular-defects-with-fixed-removable-partial-denture-prosthesis-using-precision-attachment-a-twin-case-report
#11
Vimal Kantilal Munot, Ramesh P Nayakar, Raghunath Patil
The restoration of normal function and esthetic appearance with a dental prosthesis is a major challenge in the rehabilitation of patients who have lost their teeth and surrounding bone because of surgery for oral cyst or tumor. Rehabilitation with fixed or removable prosthesis is even more challenging when the edentulous span is long and the ridge is defective. Anatomic deformities and unfavorable biomechanics encountered in the region of resection add to the misery. In such situation, a fixed-removable prosthesis allows favorable biomechanical stress distribution along with restoration of esthetics, phonetics, comfort, hygiene, and better postoperative care and maintenance...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29039986/orbital-exenteration-institutional-review-of-evolving-trends-in-indications-and-rehabilitation-techniques
#12
Hayyam Kiratli, İrem Koç
PURPOSE: To determine the changes in indications for orbital exenteration over 20 years and to assess its impact on patient survival. Evolving techniques of rehabilitation of the orbit in our institution were also evaluated. METHODS: This was a retrospective review of hospital records of patients who underwent orbital exenteration from 1995 to 2015 in a tertiary care center. Data extracted included primary location of the tumor, preoperative treatments, interval between initial diagnosis and exenteration, status of surgical margins, presence of metastatic disease, and postoperative survival...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29025610/is-endoprosthesis-safer-than-internal-fixation-for-metastatic-disease-of-the-proximal-femur-a-systematic-review
#13
Alberto Di Martino, Nicolò Martinelli, Mattia Loppini, Andrea Piccioli, Vincenzo Denaro
INTRODUCTION: Metastases to the proximal femur are usually managed surgically by tumor resection and reconstruction with an endoprosthesis, or by fixation with osteosynthesis. Still controversy remains regarding the most appropriate surgical treatment. We posed the following questions: (1) Is the frequency of surgical revision greater in patients treated with internal fixation than endoprosthetic reconstruction, and (2) Do complications that do not require surgery occur more frequently in patients treated with internal fixation rather than in those with endoprosthetic reconstruction? MATERIALS AND METHODS: A systematic review was performed of those studies reporting on surgical revision and complication rates comparing the two surgical methods...
October 2017: Injury
https://www.readbyqxmd.com/read/29023299/reconstruction-of-liposarcoma-resection-defect-with-a-made-to-measure-polyethylene-prosthesis-using-three-dimensional-digital-technology
#14
Josué Hernando, David Geijo, Ignacio Osoitz Leizaola-Cardesa, Antonio Aguilar-Salvatierra, María Carmen Gómez, Cristina Erce, Javier Martín, Gerardo Gómez-Moreno
BACKGROUND: Liposarcoma is considered one of the most frequently occurring tumors of the soft tissues, representing 17% to 30% of all mesenchymal cell tumors. It is less common in the head and neck representing <10% of tumors in this region. The reconstruction of defects derived from resection of these tumors presents a surgical challenge. New three-dimensional digital technologies allow more exact surgery, cause less morbidity, and achieve adequate aesthetic outcomes. OBJECTIVE: The aim of this article was to describe the complex reconstruction of a defect caused by the resection of a liposarcoma in the temporal region...
October 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28990681/limb-shortening-as-a-strategy-for-limb-sparing-treatment-of-appendicular-osteosarcoma-of-the-distal-radius-in-a-dog
#15
Sarah E Boston, Owen T Skinner
OBJECTIVE: To develop and report a novel limb sparing technique for the distal radius in a dog. STUDY DESIGN: Case report. ANIMAL: A 14-year-old, female spayed Labrador Retriever with an osteosarcoma of the right distal radius and a pathological fracture. A previous mast cell tumor had been treated 5 years prior to presentation with marginal excision and a full-course radiation over the right metacarpal bones. The dog had received 2 doses of palliative radiation just prior to presentation...
October 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28990090/calcineurin-nfat-signaling-pathway-mediates-titanium-particle%C3%A2-induced-inflammation-and-osteoclast-formation-by-inhibiting-rankl-and-m%C3%A2-csf-in%C3%A2-vitro
#16
Yunge Zhang, Peng Jiang, Wenbo Li, Xiangjie Liu, Yang Lu, Zhipeng Huang, Keguan Song
Wear particles serve a central role in periprosthetic osteolysis, which leads to the aseptic loosening of prostheses. In the present study a lentiviral vector was constructed to silence macrophage colony stimulating factor (M‑CSF) and receptor activator of nuclear factor κ‑B ligand (RANKL) genes, which synergistically inhibit osteoclast formation and differentiation. To confirm the role of the calcineurin/nuclear factor of activated T cells (NFAT) pathway in osteolysis, we transduced murine macrophage/monocyte RAW264...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28968315/three-dimensional-printing-a-novel-approach-to-the-creation-of-obturator-prostheses-following-palatal-resection-for-malignant-palate-tumors
#17
Michael Bartellas, Jamie Tibbo, Doug Angel, Arthur Rideout, Joshua Gillis
BACKGROUND: A subgroup of patients who have an oronasal fistula live in areas that have limited access to oral prosthetics. For these individuals, a temporary prosthesis, such as a palatal obturator, may be necessary in order to speak, eat, and breath properly. The creation of an obturator, which requires a highly trained prosthodontist, can take time and can be expensive. Through the current proof-of-concept study, there is an attempt to create a patient-specific palatal obturator through use of free and publicly available software, and a low-cost desktop 3-dimensional printer...
September 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28966964/anterior-tibial-artery-perforator-plus-flaps-role-in-coverage-of-posttumor-excision-defects-around-the-knee-joint-and-upper-leg
#18
Harshvardhan Sahijwani, Vikas Warikoo, Abhijeet Ashok Salunke, Jaymin Shah, Preetish Bhavsar, Rahul Wagh, Subodh Pathak
OBJECTIVE: Posttumor excision defects can be very large, and many do require postoperative radiotherapy. It is therefore important to provide stable and durable wound coverage to provide ability to withstand radiotherapy as well as providing cover to vital structures. METHODS: Between July 2014 and June 2016, eight females and six male patients with defects around the knee were operated upon using a perforator plus flap from the anterior tibial artery perforator...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28964387/-resection-of-recurrent-neck-cancers-with-replacement-of-the-carotid-artery
#19
J-B Ricco, G Illuminati, R Belmonte
OBJECTIVES: The management of patients with recurrent neck cancer invading the carotid artery is controversial. The aim of this study was to evaluate the overall survival and healthy survival years (QALY) as well as the patency of carotid revascularization after enbloc tumor resection followed by complementary radiotherapy. METHODS: From 2000 to 2016, 42 consecutive patients with recurrent neck cancer invading the carotid artery underwent resection of the tumor associated with reconstruction of the carotid artery with a PTFE prosthesis (n=31) or with a saphenous vein graft (n=11)...
October 2017: J Med Vasc
https://www.readbyqxmd.com/read/28950989/soft-obturator-prosthesis-for-postoperative-soft-palate-carcinoma-a-clinical-report
#20
Tomohisa Ohno, Kyoko Hojo, Ichiro Fujishima
An intraoral prosthesis with a soft flexible obturator was provided for a patient with a soft palate perforation after surgical and chemoradiotherapy treatments of a soft palate tumor. An obturator composed of movable and flexible silicone was attached to a structure similar to a palatal lift; it was therefore able to move according to the movement of the soft palate, which was confirmed by endoscopic examination. The application of this prosthesis resulted in complete disappearance of hypernasality and food reflux, and the patient was able to eat without particular limitation during daytime wearing...
September 23, 2017: Journal of Prosthetic Dentistry
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