Mi Kyung Kim, Sang Woon Chung, Dae Hyun Kim, Ji Min Kim, Eun Kyeong Lee, Ji Young Kim, Young Mi Ha, Yun Hee Kim, Jae-Kyung No, Hye Sun Chung, Kun-Young Park, Sook Hee Rhee, Jae Sue Choi, Byung Pal Yu, Takako Yokozawa, Young Jin Kim, Hae Young Chung
Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat...
June 2010: Experimental Gerontology