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Yasuhiro Takeuchi
Bisphosphonates are standard medicine for treatment of osteoporosis, and have been inovated to overcome complicated rules for their appropriate administration or their poor intestinal absorption. Not only weekly but also monthly oral bisphosphonates have been available. Furthermore, we are now allowed to choose intravenous administration of bisphosphonates for osteorporosis. Good persistance and adherence is another critical and essential issue to be solved to achive the aim of osteoprosis treatment with bisphosphonates...
2017: Clinical Calcium
P Gierer, T Mittlmeier
The incidence of femoral neck fractures increases exponentially with rising age. Young patients are rarely affected but when they are it is mostly due to high energy accidents, whereas older patients suffer from femoral neck fractures by low energy trauma due to osteoporotic changes of the bone mineral density. Treatment options have not essentially changed over the last few years. Non-operative treatment may be a choice in non-dislocated and impacted fractures. Due to the high risk of secondary fracture displacement prophylactic screw osteosynthesis is recommended even in Garden type I fractures...
March 2015: Der Unfallchirurg
Yun-Fan Ti, Rui Wang, Jian-Ning Zhao
Osteoclast, a huge coenocytes,originates from mononuclear macrophages or monocytic series hematopoietic precursor cell, plays an important role in the progree of bone resorption. Formation and abnormal activity of osteoclast may cause osteoprosis, rheumatoid arthritis and aseptic loosening after arthroplasty. Therefore, osteoclast is the target for treating these disease. At present, a lot of study on formation of osteoclast were reported, but the study on how to identify and degradation of bone tissue is not yet reported...
June 2014: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Ting Liu, Chun-yan Lu, Yan-hong Guo, Qin Wang, De-cai Chen
OBJECTIVE: To study the optimal cut-off value of phalangeal radiographic absorptiometry (RA) to identify osteoporosis in postmenopausal women. METHODS: A total of 650 postmenopausal women were recruited in this study. Bone mineral density (BMD) at lumbar spine and left proximal femur neck was measured by dual-energy X-ray absorptiometry (DXA) as the standard method to identify postmenopausal osteoprosis. Phalangeal bone density was estimated by the use of RA. Optimal cut-off value of phalangeal RA was determined using a ROC curve for screening the ostreoporosis cases...
May 2014: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Yasuhiro Takeuchi
Teriparatide is an only available bone anabolic drug in practice. It is a N-terminal fragment of parathyroid hormone (PTH) . Mode of actions of teriparatide is pharmacological but not physiological as it is administered to patients with osteoporosis. Physicians need to understand the fact that treatment with teriparatide is not just like a hormone replacement. They also should administer teriparatide to their patients after rigorous evaluation of its clinical superiority to other anti-osteoprosis drugs, because it is not classified as a first-line drug...
June 2014: Clinical Calcium
Pasi Pulkkinen, Simo Saarakkala, Miika T Nieminen, Timo Jämsä
BACKGROUND: Assessment of osteoporotic fracture risk is based primarily on bone mineral density (BMD) measurements using dual X-ray absorptiometry (DXA). METHODS: However, recent evidence indicates that the method is insufficient for accurate individual risk assessment; in addition to methodological inaccuracies related to DXA, the mechanical strength of bone is influenced not only by low BMD but also by other factors that are not captured by DXA. RESULTS: DXA-based BMD can provide information on the amount of bone but does not elucidate bone structure, which is significant for bone mechanical strength and for fracture risk...
May 2013: European Radiology
Mohammad Taghi Karimi
Spinal Cord Injury (SCI) is damage to spinal cord, which is categorized according to the extent of functional loss, sensation loss and inability of the subjects to stand and walk. The patients use two transportation systems including orthosis and wheelchair. It was claimed that standing and walking bring some benefits such as decreasing bone osteoporosis, prevention of pressure sores, and improvement of the function of the digestive system for SCI patients. Nevertheless, the question of wether or not there is enough evidence to support the effect of walking with orthosis on the health status of the subjects with SCI remains unanswered...
December 2011: Iranian Journal of Medical Sciences
N Cohan, S Sarikhani, S Moslemi, M Karimi
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival...
January 2011: Iranian Red Crescent Medical Journal
Wei-Jie Kang, Chen-Bo Xia, Yong-Jun Deng, Ju-Shi Zhang
OBJECTIVE: To investigate the therapic choice of intertrochanteric fractures of femur in aged patient. METHODS: From June 2006 to June 2010,58 patients with intertrochanteric fracture were treated with surgical methods. There were 25 males and 33 females, aged from 65 to 93 years old (averaged 79 years old). According to the Evans type, type I was in 30 cases, type II was in 28 cases. Of them, 25 patients were treated with hip replacement (group A) and 33 patients were treated with internal fixation (group B)...
January 2012: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Mi Kyung Kim, Sang Woon Chung, Dae Hyun Kim, Ji Min Kim, Eun Kyeong Lee, Ji Young Kim, Young Mi Ha, Yun Hee Kim, Jae-Kyung No, Hye Sun Chung, Kun-Young Park, Sook Hee Rhee, Jae Sue Choi, Byung Pal Yu, Takako Yokozawa, Young Jin Kim, Hae Young Chung
Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat...
June 2010: Experimental Gerontology
Keizo Ohnaka, Ryoichi Takayanagi
Both androgen and estrogen play important roles in bone metabolism. As estrogen has a potent inhibitory effect on bone resorption, bone turnover increases in postmenopausal osteoprosis caused by estrogen deficiency. Treatment with selective estrogen receptor modulator (SERM) as well as hormone replacement therapy (HRT) improve bone turnover increased in postmenopausal women to normal range before menopause. Although the decrease of androgen level with aging is involved in pathogenesis of male osteoporosis, the detailed mechanism remains to be clarified...
August 2009: Clinical Calcium
Ivy M Alexander
No abstract text is available yet for this article.
June 2009: Nurse Practitioner
Wei Cheng, Ming-Dong Guo, Wen-Quan Zhou
No abstract text is available yet for this article.
June 2008: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Emilia Lewczuk, Dariusz Białoszewski
Background. Thanks to modern methods of diagnosis, treatment and rehabilitation, we currently possess the means to counteract the consequences of osteoprosis and limit the number of falls in osteoporotic patients. Material and methods. Based on an original questionnaire, we analyzed a group of 54 patients (48 women and 6 men) under treatment for osteoporosis in order to assess the level of physical activity and the reasons for its reduction in patients with osteoporosis, to determine the situations mostly endangered by falls, and to survey the opinion of patients regarding the need for a rehabilitation program to prevent falls...
August 31, 2006: Ortopedia, Traumatologia, Rehabilitacja
T Pufe, H Claassen, K E Scholz-Ahrens, D Varoga, W Drescher, A T M Franke, C Wruck, W Petersen, C Cellarius, J Schrezenmeir, C-C Glüer
Ovariectomy (OVX) in animal models is an accepted method to simulate postmenopausal osteoprosis. Vascular endothelial growth factor (VEGF) has been recently shown to play an important role during endochondral bone formation, hypertrophic cartilage remodeling, ossification, and angiogenesis. We hypothesized that reduced VEGF expression in bone contributes to OVX-induced bone loss and tested it in a miniature pig model and in vitro using human osteoblasts. Seventeen primiparous sows (Göttingen miniature pigs) were allocated to two experimental groups when they were 30 months old: a control group (n = 9) and an OVX group (n = 8)...
March 2007: Calcified Tissue International
B Röhrl, M Sadick, K Brocker, J Brade, G Voggenreiter, U Obertacke, C Düber
PURPOSE: To evaluate the value of MDCT in the monitoring of vertebral body architecture after balloon kyphoplasty and observe morphological changes of the vertebral body. MATERIAL AND METHODS: During a period of 26 months, 66 osteoporotic fractures of the vertebral bodies were treated with percutanous balloon kyphoplasty. The height of the vertebral body, width of spinal space, sagittal indices, kyphosis und COBB angle, and cement leakage were evaluated by computed tomography before and after treatment and in a long-term follow up...
August 2006: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Kazuhiro Aoki, Keiichi Ohya
The experimental model of ovariectomy (OVX) has been well used as a model for studying the pathogenesis of postmenopausal osteoporosis. It is known that the hematopoietic environment in the bone marrow is altered leading to the up-regulation of osteoclastogenesis after the estrogen withdrawal. We discuss the possibility whether this alternation of lymphocyte-lineage cells could trigger off a risk factor for the periodontal disease.
May 2003: Clinical Calcium
Amr A el-Husseini, Amgad E el-Agroudy, Ehab W Wafa, Tarek Mohsen, Mohamed A Sobh, Mohamed A Ghoneim
Successful kidney transplantation corrects many of the metabolic abnormalities associated with development of renal osteodystrophy, but despite a well-functioning graft, osteopenia, remains prevalent in adult and pediatric kidney recipients. The factors that affect the bone mineral density (BMD) and the long term course of BMD after transplantation in children is still unknown. We performed a cross sectional study to determine BMD in 83 recipients who received living renal allotransplants in Mansoura Urology & Nephrology Center between 1981 and 2002 (mean age at transplantation 13...
2004: International Urology and Nephrology
No abstract text is available yet for this article.
July 23, 1962: El Día Médico
No abstract text is available yet for this article.
August 1959: Revue du Rhumatisme et des Maladies Ostéo-articulaires
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